hesperidin has been researched along with naringenin in 124 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.61) | 18.7374 |
| 1990's | 8 (6.45) | 18.2507 |
| 2000's | 39 (31.45) | 29.6817 |
| 2010's | 63 (50.81) | 24.3611 |
| 2020's | 12 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, K; Cheng, YC; Hu, CQ; Kilkuskie, RE; Lee, KH; Shi, Q | 1 |
| Bailey, DG; Dawson, PA; Dresser, GK; Freeman, DJ; Kim, RB; Leake, BF; Schwarz, UI | 1 |
| Bronze, MR; Mendes, T; Serra, H; Simplício, AL | 1 |
| Du, GH; Lee, SM; Liu, AL; Wang, HD; Wang, YT | 1 |
| Amić, D; Lucić, B | 1 |
| Estrada-Soto, S; Figueroa, M; Hernández-Abreu, O; Ibarra-Barajas, M; Navarrete-Vázquez, G; Torres-Piedra, M | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Bijak, M; Krotkiewski, H; Nowak, P; Pawlaczyk, I; Ponczek, M; Saluk, J; Wachowicz, B; Ziewiecki, R | 1 |
| Chauvaux, N; De Greef, J; John, M; Prinsen, E; Schell, J; Schmidt, J; Van Onckelen, H; Wieneke, U | 1 |
| Guengerich, FP; Kim, DH | 1 |
| Kaul, TN; Middleton, E; Ogra, PL | 1 |
| Kroyer, G | 1 |
| Bonina, F; Castelli, F; Lanza, M; Marzullo, D; Saija, A; Scalese, M | 1 |
| Carroll, KK; Chambers, AF; Guthrie, N; Moussa, M; So, FV | 1 |
| Balentine, DA; Conney, AH; Loder, DP; Taneja, N; Zhu, BT | 1 |
| Borradaile, NM; Carroll, KK; Kurowska, EM | 1 |
| Bae, EA; Han, MJ; Kim, DH | 1 |
| Johnson, MK; Loo, G | 1 |
| Alfthan, G; Aro, A; Erlund, I; Meririnne, E | 1 |
| Borradaile, NM; de Dreu, LE; Huff, MW; Wilcox, LJ | 1 |
| Chovanec, P; Kropácová, M; Lisá, L; Nemcová, M; Novák, K; Skrdleta, V | 1 |
| Aromaa, A; Hakulinen, T; Heliövaara, M; Järvinen, R; Knekt, P; Kumpulainen, J; Reunanen, A; Rissanen, H | 1 |
| Alfthan, G; Aro, A; Erlund, I; Kesäniemi, YA; Rantala, M; Silaste, ML | 1 |
| Alzuru, M; Mendez, J; Paredes, A; Rodríguez-Ortega, M | 1 |
| Bouteloup-Demange, C; Gil-Izquierdo, A; Manach, C; Morand, C; Rémésy, C | 1 |
| Abbott, NJ; Dobbie, MS; Kuhnle, G; Proteggente, AR; Rice-Evans, C; Youdim, KA | 1 |
| Duh, PD; Huang, SL; Tsai, HL; Yen, GC | 1 |
| Chen, YC; Lin, HY; Shen, SC | 2 |
| Georgarakis, M; Kanaze, FI; Kokkalou, E; Niopas, I | 1 |
| Erb, A; Kraus, M; Labib, S; Richling, E; Wickert, T | 1 |
| Daugherty, A; Kurowska, EM; Manthey, JA; Whitman, SC | 1 |
| Liu, F; Peng, Y; Ye, J | 1 |
| Huong, DT; Ide, T; Takahashi, Y | 1 |
| Bounartzi, MI; Georgarakis, M; Kanaze, FI; Niopas, I | 1 |
| Jung, S; Kwon, C; Park, H | 1 |
| Gardana, C; Guarnieri, S; Porrini, M; Riso, P; Simonetti, P | 1 |
| Jing, Y; Liang, XM; Xu, Q; Xue, XY; Zhang, FF; Zhou, DY | 1 |
| Bennett, RN; Bisignano, G; Faulds, CB; Gasson, MJ; Mandalari, G; Narbad, A; Saija, A; Trombetta, D | 1 |
| Andrews, PK; Davies, NM; Miranda, ND; Remsberg, CM; Vega-Villa, KR; Yáñez, JA | 1 |
| Cheng, YY; Liu, L; Xu, DM | 1 |
| Lien, TF; Su, WT; Yeh, HS | 1 |
| Liu, Y; Song, R; Tian, Y; Xu, F; Zhang, Z | 1 |
| Bourland, TC; Miller, EG; Patil, BS; Peacock, JJ; Taylor, SE; Wright, JM | 1 |
| Cheng, YY; Liu, L; Lu, XP; Ning, ZQ; Shan, S; Zhang, K | 1 |
| Ignatowicz, E; Zielińska-Przyjemska, M | 1 |
| Kasmas, S; Niopas, I; Spanakis, M | 1 |
| Jung, S; Kwon, C; Paik, SR | 1 |
| Hanada, H; Handa, K; Hirota, K; Mochizuki, H; Morikawa, K; Nonaka, M | 1 |
| Denny, BJ; Mathew, TC; West, PW | 1 |
| Cevallos-Cevallos, JM; Reyes-De-Corcuera, JI; Rouseff, R | 1 |
| Lee, HY; Rodriguez-Mateos, A; Spencer, JP; Vafeiadou, K; Vauzour, D; Williams, RJ | 1 |
| De Luca, G; Di Donna, L; Mazzotti, F; Napoli, A; Salerno, R; Sindona, G; Taverna, D | 1 |
| Barmpalexis, P; Bikiaris, D; Georgarakis, E; Kanaze, FI; Kokkalou, E; Niopas, I | 1 |
| Fang, F; Huang, Z; Wang, J; Wong, CW | 1 |
| Barron, D; Bouisset, F; Bredsdorff, L; Cornett, C; Nielsen, IL; Offord, E; Rasmussen, SE; Williamson, G | 1 |
| Bredsdorff, L; Haraldsdóttir, J; Knuthsen, P; Krogholm, KS; Rasmussen, SE | 1 |
| Cao, H; Chen, X; Lv, H; Sakurai, T; Sun, H; Sun, W; Wang, X; Zhou, J | 1 |
| Kai, H; Kawai, K; Ogata, K; Shuto, T; Takamura, N; Tokunaga, J; Yoshida, H | 1 |
| Boza, J; Cerdá, B; Escudero, E; Espín, JC; García-Conesa, MT; Larrosa, M; Tomás-Barberán, FA; Vallejo, F; Zafrilla, MP | 1 |
| Dong, H; Liu, Y; Song, R; Xu, F; Zhang, Z | 1 |
| Dube, V; Joseph, SK; Lakshmi, V; Mishra, SK; Murthy, PK; Sahoo, MK; Srivastava, S; Verma, SK | 1 |
| Fu, H; Fujii, K; Hata, K; Katsumura, Y; Lin, M; Muroya, Y; Shikazono, N; Yokoya, A | 1 |
| Eggett, DL; Freeman, BL; Parker, TL | 1 |
| Higashi, K; Moribe, K; Takeuchi, H; Tozuka, Y; Uchiyama, H; Yamamoto, K; Zhang, J | 1 |
| Arai, T; Hamashima, Y; Hasegawa, J; Kajimoto, T; Node, M; Suzuki, N; Tanaka, R; Tokuda, H; Tsujii, H; Yamada, T | 1 |
| Leung, LK; Li, F; Lin, SM; Ye, L | 1 |
| Breadmore, MC; Li, Y; Lu, Y; Yao, Q; Zhong, H | 1 |
| Bi, K; Gao, J; Sun, H; Tong, L; Zhou, D; Zhu, Y | 1 |
| Duan, JA; Lu, LL; Qian, DW; Qian, YF; Shu, Y; Su, SL; Xue, CF | 1 |
| Hegde, AH; Prashanth, SN; Seetharamappa, J | 1 |
| Bae, JT; Kim, GB; Ko, HJ; Lee, GS; Pyo, HB | 1 |
| Iinuma, M; Masuda, M; Matsuda, H; Murata, K; Takano, S | 1 |
| Dong, T; Han, Y; Sakurai, T; Sun, H; Wang, X; Wu, X; Yan, G; Yang, J; Zhang, A | 1 |
| Konrad, M; Mohr, F; Oberwinkler, J; Philipp, SE; Schaefer, M; Stab, J; Straub, I | 1 |
| Ferruzzi, MG; Jouni, ZE; Song, BJ | 1 |
| Assini, JM; Huff, MW; Mulvihill, EE | 1 |
| Bennetau-Pelissero, C; Bérard, AM; Chanet, A; Claude, S; Kamran Khan, M; Maier, JA; Mazur, A; Milenkovic, D; Morand, C; Rakotomanomana, N; Shinkaruk, S | 1 |
| Asghari, A; Barfi, A; Barfi, B; Rajabi, M; Saeidi, I | 1 |
| Ahn, DU; Kim, KT; Lee, JH; Moon, SH; Nah, SY; Paik, HD; Park, YS | 1 |
| Nam, HK; Oh, DK; Shin, KC | 1 |
| Bracht, A; Constantin, J; Constantin, RP; Ishii-Iwamoto, EL; Yamamoto, NS | 1 |
| Bracht, A; Constantin, J; Constantin, RP; do Nascimento, GS; Ishii-Iwamoto, EL; Salgueiro, CL; Yamamoto, NS | 1 |
| Arikan, S; Ersan, I; Gencer, B; Hanci, V; Kara, S; Karaboga, I; Karaca, T; Tufan, HA | 1 |
| Feng, F; Liu, XY | 1 |
| Borges, G; Clifford, MN; Crozier, A; Del Rio, D; Kellerhals, MB; Lean, ME; Pereira-Caro, G; Roberts, SA; van der Hooft, J | 1 |
| Borges, G; Calani, L; Clifford, MN; Crozier, A; Del Rio, D; Ky, I; Pereira-Caro, G; Ribas, A; Roberts, SA | 1 |
| Ansarin, K; Kolahian, S; Pour Moghaddam, M; Sakhinia, E; Sakhinia, M; Seyedrezazadeh, E; Shahbazfar, AA; Vafa, M | 1 |
| Cassidy, A; Franke, AA; Hu, FB; Pan, A; Rimm, EB; Sun, Q; Townsend, MK; Tworoger, SS; van Dam, RM; Wedick, NM | 1 |
| Bansal, AK; Modi, SR; Shete, G | 1 |
| Kilaru, N; Mullapudi, SS; Nuthakki, S; Pendyala, S; Pingili, R; Vemulapalli, S | 1 |
| Albuquerque, RM; Beraldo, H; de Azevedo, RA; Ferreira, AK; Gouvea, LR; Louro, SR; Sousa, AC; Tamayo, LV; Teixeira, SF | 1 |
| Macedo, GA; Macedo, JA; Madeira, JV; Nakajima, VM | 1 |
| Baranowska, I; Hejniak, J; Magiera, S | 2 |
| Cheng, K; Gao, H; Guo, BH; Liu, K; Liu, XH; Liu, Y; Wang, W; Yao, HL | 1 |
| Berná, G; Cerrillo, I; Escudero-López, B; Fernández-Pachón, MS; Ferreres, F; Gil-Izquierdo, Á; Herrero-Martín, G; Hornero-Méndez, D; Martín, F; Medina, S | 1 |
| Chandrika, BB; Haridas, M; Kumar, TRS; Sabu, A; Steephan, M | 1 |
| Aschoff, JK; Bosy-Westphal, A; Carle, R; Cooperstone, JL; Högel, J; Riedl, KM; Schwartz, SJ; Schweiggert, RM | 1 |
| Ajdžanović, V; Blagojević, D; Konić-Ristić, A; Milenković, D; Miler, M; Milošević, V; Oreščanin-Dušić, Z; Šošić-Jurjević, B; Živanović, J | 1 |
| Crozier, A; Fernández-Quirós, B; Ludwig, IA; Moreno-Rojas, JM; Pereira-Caro, G; Pradas, I | 1 |
| Liu, D; Liu, M; Takau, I; Wu, J; Xia, C; Xie, H; Xiong, Y; Zhang, H | 1 |
| Johnson, EJ; Köck, K; Paine, MF; Won, CS | 1 |
| Li, J; Li, JY; Ren, HY; Su, H; Tang, WF; Wu, FS; Zhang, YM; Zhao, XL | 1 |
| Barreca, D; Bellocco, E; Calderaro, A; Daglia, M; Gattuso, G; Laganà, G; Meneghini, S; Nabavi, SM; Smeriglio, A; Trombetta, D | 1 |
| Bai, Y; Chen, T; Peng, W; Su, M; Su, W; Wang, J; Yan, Z; Yao, H; Zeng, X; Zheng, Y | 1 |
| Crozier, A; Garcia, AL; Ludwig, IA; Malkova, D; Moreno-Rojas, JM; Nastase, AM; Pereira-Caro, G; Polyviou, T | 1 |
| Bracht, A; Constantin, J; Constantin, RP; de Castro Ghizoni, CV; do Nascimento, GS; Gilglioni, EH; Ishii-Iwamoto, EL; Utsunomiya, KS; Yamamoto, NS | 1 |
| Jun, M; Lee, J; Lee, S; Lim, G; Youn, K | 1 |
| He, J; Huang, X; Ren, P; Shi, S; Wang, J; Xu, J; Yan, H | 1 |
| El Daibani, AA; Liu, MC; Luo, L; Mei, X; Xi, Y; Yasuda, S; Zhou, C | 1 |
| Kim, DH; Kim, JH; Lee, J | 1 |
| Camp, JV; Grootaert, C; Jonkers, D; Masclee, A; Possemiers, S; Rymenant, EV; Stevens, Y | 1 |
| Achaintre, D; Agudo, A; Boeing, H; Boutron-Ruault, MC; Cayssials, V; Garro-Aguilar, Y; Huybrechts, I; Karakatsani, A; Katzke, V; Kühn, T; Macciotta, A; Mahamat-Saleh, Y; Mancini, FR; Palli, D; Santucci de Magistris, M; Scalbert, A; Sieri, S; Tahiri, I; Trichopoulou, A; Tumino, R; Valanou, E; Zamora-Ros, R | 1 |
| Cai, X; Huang, D; Lei, Y; Lin, M; Luo, K; Sun, Z; Tan, S; Wang, Y; Xia, X; Yan, J; Zhang, Y | 1 |
| Araujo-León, JA; Cantillo-Ciau, Z; Coral-Martínez, TI; Oney-Montalvo, JE; Ortiz-Andrade, R; Vera-Sánchez, RA | 1 |
| Antony, PJ; Gan, RY; Gandhi, GR; Geng, F; Gurgel, RQ; Li, H; Li, HB; Narain, N; Vasconcelos, ABS; Wu, DT | 1 |
| Carnauba, RA; Hassimotto, NMA; Lajolo, FM | 1 |
| Ganswind, K; Hübner, F; Humpf, HU; Lindemann, V; Saenger, T | 1 |
| Bai, YF; Fan, XY; Fu, JQ; Sheng, H; Wang, SW; Weng, YY; Zhang, F; Zheng, F | 1 |
| Garofalo, A; Grande, F; Ioele, G; Occhiuzzi, MA; Perri, MR; Rizzuti, B; Statti, G | 1 |
| Uchiyama, H | 1 |
| Duarte, D; Silva-Lima, B; Sousa, C; Videira, M | 1 |
| Huang, X; Liu, J; Shan, Y; Tian, M; Wang, Z; Xiao, F | 1 |
6 review(s) available for hesperidin and naringenin
| Article | Year |
|---|---|
Citrus flavonoids and lipid metabolism.
Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Citrus; Dyslipidemias; Flavanones; Flavones; Hesperidin; Humans; Hypolipidemic Agents; Inflammation; Lipid Metabolism; Oxidation-Reduction; Phytotherapy | 2013 |
Flavanones: Citrus phytochemical with health-promoting properties.
Topics: Animals; Antioxidants; Citrus; Flavanones; Flavonoids; Hesperidin; Humans; Oxidative Stress | 2017 |
The Intestinal Fate of Citrus Flavanones and Their Effects on Gastrointestinal Health.
Topics: Animals; Bacteria; Biological Availability; Citrus; Colon; Flavanones; Fruit; Gastroenteritis; Gastrointestinal Microbiome; Hesperidin; Humans; Intestinal Absorption; Intestine, Small | 2019 |
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.
Topics: Animals; Antioxidants; Citrus; Diabetes Mellitus; Disaccharides; Flavanones; Flavones; Flavonoids; Glycosides; Hesperidin; Humans; Inflammation; Phytochemicals; Polyphenols; Propiophenones | 2020 |
[Construction of Coamorphous Technology Aimed at Improving Membrane Permeability and Application to Emulsion].
Topics: Biological Availability; Cell Membrane Permeability; Crystallization; Drug Design; Drug Stability; Emulsions; Flavanones; Hesperidin; Oils; Phase Transition; Solubility; Temperature; Water | 2021 |
Repurposing Natural Dietary Flavonoids in the Modulation of Cancer Tumorigenesis: Decrypting the Molecular Targets of Naringenin, Hesperetin and Myricetin.
Topics: Carcinogenesis; Flavanones; Flavonoids; Hesperidin; Humans; Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases | 2022 |
6 trial(s) available for hesperidin and naringenin
| Article | Year |
|---|---|
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.
Topics: Administration, Oral; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Beverages; Biological Availability; Carrier Proteins; Citrus; Double-Blind Method; Female; Flavonoids; Food-Drug Interactions; Fruit; HeLa Cells; Histamine H1 Antagonists; Humans; Intestinal Absorption; Male; Malus; Membrane Transport Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Symporters; Terfenadine | 2002 |
Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.
Topics: Adult; Biomarkers; Cross-Over Studies; Feeding Behavior; Female; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Middle Aged; Quercetin; Reference Values; Time Factors; Vegetables | 2002 |
Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects.
Topics: Beverages; Biological Availability; Citrus sinensis; Cross-Over Studies; Disaccharides; Double-Blind Method; Female; Flavanones; Fruit; Glucosides; Glycoside Hydrolases; Hesperidin; Humans; Male; Placebos | 2010 |
Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.
Topics: Adult; Area Under Curve; Biological Availability; Diet; Flavanones; Hesperidin; Humans; Male; Quercetin; Young Adult | 2010 |
Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study.
Topics: Adult; Biological Availability; Citrus sinensis; Cross-Over Studies; Dose-Response Relationship, Drug; Flavanones; Food Analysis; Fruit; Fruit and Vegetable Juices; Hesperidin; Hippurates; Humans; Pasteurization; Tandem Mass Spectrometry; Young Adult | 2016 |
Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes.
Topics: Athletes; Biological Availability; Chromatography, High Pressure Liquid; Citrus sinensis; Colon; Diet; Exercise; Flavanones; Fruit; Fruit and Vegetable Juices; Glucuronides; Hesperidin; Humans; Male; Mass Spectrometry; Oxygen Consumption; Physical Endurance; Plant Extracts; Polyphenols; Rest; Sports | 2017 |
112 other study(ies) available for hesperidin and naringenin
| Article | Year |
|---|---|
Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.
Topics: Antiviral Agents; Cells, Cultured; Flavonoids; Galactosides; HIV-1; Humans; Mass Spectrometry; Medicine, Chinese Traditional; Plants, Medicinal; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Virus Replication; Zidovudine | 1994 |
Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.
Topics: Caco-2 Cells; Electrophoresis, Capillary; Flavanones; Flavones; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Molecular Structure; Molecular Weight | 2008 |
Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities.
Topics: Animals; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Dogs; Flavonoids; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza B virus; Molecular Structure; Neuraminidase; Orthomyxoviridae; Structure-Activity Relationship | 2008 |
Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.
Topics: Flavonoids; Free Radical Scavengers; Models, Biological; Quantitative Structure-Activity Relationship; Quantum Theory; Software; Thermodynamics | 2010 |
Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches.
Topics: Animals; Aorta; Calmodulin; Dose-Response Relationship, Drug; Flavonoids; In Vitro Techniques; Models, Molecular; Rats; Rats, Wistar; Vasodilator Agents | 2011 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Thrombin inhibitory activity of some polyphenolic compounds.
Topics: | 2014 |
Stimulation of indole-3-acetic acid production in Rhizobium by flavonoids.
Topics: Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Gene Expression Regulation, Bacterial; Hesperidin; Indoleacetic Acids; Isoflavones; Kinetics; Luteolin; Rhizobium | 1991 |
In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids.
Topics: Aflatoxins; Chamomile; Chromatography, High Pressure Liquid; Dihydropyridines; Felodipine; Flavanones; Flavins; Flavonoids; Gene Expression Regulation; Hesperidin; Humans; In Vitro Techniques; Kaempferols; Microsomes, Liver; Oils, Volatile; Plants, Medicinal; Quercetin; Transcriptional Activation | 1990 |
Antiviral effect of flavonoids on human viruses.
Topics: Animals; Catechin; Cell Line; Flavanones; Flavonoids; Hesperidin; Humans; Parainfluenza Virus 3, Human; Poliovirus; Quercetin; Respiratory Syncytial Viruses; Simplexvirus; Viral Plaque Assay; Virus Physiological Phenomena; Virus Replication; Viruses | 1985 |
[The antioxidant activity of citrus fruit peels].
Topics: Antioxidants; Ascorbic Acid; Citrus; Flavanones; Flavonoids; Freeze Drying; Hesperidin; Vitamin E | 1986 |
Flavonoids as antioxidant agents: importance of their interaction with biomembranes.
Topics: Animals; Antioxidants; Brain; Calorimetry, Differential Scanning; Cell Membrane; Ferrous Compounds; Flavanones; Flavonoids; Hesperidin; Lipid Peroxidation; Liposomes; Male; Malondialdehyde; Oxidation-Reduction; Quercetin; Rats; Rats, Sprague-Dawley; Rutin; Thermodynamics; Thiobarbituric Acid Reactive Substances | 1995 |
Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Beverages; Breast Neoplasms; Cell Division; Citrus; Female; Flavanones; Flavonoids; Genistein; Hesperidin; Humans; Isoflavones; Mammary Neoplasms, Experimental; Quercetin; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 1996 |
Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone.
Topics: Animals; Enzyme Inhibitors; Estradiol; Estrone; Female; Flavanones; Flavonoids; Glucuronates; Glucuronosyltransferase; Hesperidin; Kinetics; Mice; Mice, Inbred Strains; Microsomes, Liver; Nitrophenols; Phenols; Polymers; Rats; Rats, Inbred Strains; Tea; Uridine Diphosphate Glucuronic Acid | 1998 |
Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin.
Topics: Apolipoproteins B; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flavanones; Flavonoids; Hesperidin; Humans; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1999 |
In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites.
Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Flavanones; Flavonoids; Gastric Mucosa; Helicobacter pylori; Hesperidin; Humans; Microbial Sensitivity Tests; Phenols; Pyloric Antrum | 1999 |
Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.
Topics: Antioxidants; Bepridil; Biphenyl Compounds; Catechin; Comet Assay; DNA; DNA Damage; Flavanones; Flavonoids; Free Radical Scavengers; Genistein; Hesperidin; Humans; Indicators and Reagents; Isoflavones; Jurkat Cells; Molsidomine; Nitric Oxide Donors; Oxidation-Reduction; Picrates; Quercetin | 2000 |
Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice.
Topics: Adult; Antioxidants; Area Under Curve; Beverages; Biological Availability; Biomarkers; Chromatography, High Pressure Liquid; Citrus; Diet; Estrogen Antagonists; Female; Flavanones; Flavonoids; Hesperidin; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Urinalysis | 2001 |
Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.
Topics: Anticholesteremic Agents; Apolipoproteins B; Carcinoma, Hepatocellular; Carrier Proteins; Cholesterol; Cholesterol Esters; Citrus; Enzyme-Linked Immunosorbent Assay; Flavanones; Flavonoids; Hepatocytes; Hesperidin; Humans; Receptors, LDL; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2; Triglycerides; Tumor Cells, Cultured | 2001 |
Effect of exogenous flavonoids on nodulation of pea (Pisum sativum L.).
Topics: beta-Galactosidase; Flavanones; Flavonoids; Hesperidin; Hydroponics; Nitrogenase; Pisum sativum; Plant Roots; Quercetin; Rhizobium leguminosarum; Symbiosis | 2002 |
Flavonoid intake and risk of chronic diseases.
Topics: Adult; Arthritis, Rheumatoid; Asthma; Cataract; Cerebrovascular Disorders; Chronic Disease; Diabetes Mellitus, Type 2; Diet; Female; Flavanones; Flavonoids; Hesperidin; Humans; Kaempferols; Lung Neoplasms; Male; Middle Aged; Mortality; Myocardial Ischemia; Neoplasms; Prostatic Neoplasms; Quercetin; Risk; Risk Factors; Surveys and Questionnaires | 2002 |
Anti-Sindbis activity of flavanones hesperetin and naringenin.
Topics: Animals; Antiviral Agents; Cricetinae; Flavanones; Flavonoids; Hesperidin; Sindbis Virus | 2003 |
Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice.
Topics: Adult; Beverages; Biological Availability; Chromatography, High Pressure Liquid; Citrus; Dose-Response Relationship, Drug; Flavanones; Flavonoids; Hesperidin; Humans; Male; Reference Values; Time Factors | 2003 |
Interaction between flavonoids and the blood-brain barrier: in vitro studies.
Topics: Animals; Anthocyanins; Blood-Brain Barrier; Brain; Cell Line; Chromatography, High Pressure Liquid; Coculture Techniques; Endothelium, Vascular; Flavanones; Flavonoids; Glioma; Glucuronides; Hesperidin; Mass Spectrometry; Mice; Microcirculation; Rats | 2003 |
Pro-oxidative properties of flavonoids in human lymphocytes.
Topics: Cell Survival; Deoxyribose; DNA Damage; Flavanones; Flavonoids; Hesperidin; Humans; Hydrogen Peroxide; Lymphocytes; Membrane Proteins; Oxidants; Oxidation-Reduction; Quercetin; Superoxides | 2003 |
Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.
Topics: Apoptosis; beta-Glucosidase; Caspase 1; Caspase 3; Caspases; Drug Interactions; Flavanones; Flavonoids; Glycoside Hydrolases; Guanine Nucleotide Dissociation Inhibitors; Hesperidin; HL-60 Cells; Humans; Multienzyme Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neutrophils; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; rho Guanine Nucleotide Dissociation Inhibitor beta; rho-Specific Guanine Nucleotide Dissociation Inhibitors | 2003 |
Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma.
Topics: Chromatography, High Pressure Liquid; Citrus; Flavanones; Fruit; Hesperidin; Humans; Quality Control; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Disaccharides; Drug Stability; Drug Synergism; Flavanones; Flavonoids; Glycosylation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hesperidin; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peritoneum; RNA Stability; RNA, Messenger; Teichoic Acids | 2005 |
The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.
Topics: Animals; Cecum; Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Hesperidin; Models, Animal; Quercetin; Spectrometry, Mass, Electrospray Ionization; Swine | 2004 |
Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.
Topics: Animals; Cell Membrane; Cells, Cultured; Citrus; Flavanones; Flavones; Fruit; Hesperidin; Lipoproteins, LDL; Lipoproteins, VLDL; Macrophages; Mice; Receptors, Immunologic; Receptors, Scavenger; Scavenger Receptors, Class A | 2005 |
Quantitative and qualitative analysis of flavonoid markers in Frucus aurantii of different geographical origin by capillary electrophoresis with electrochemical detection.
Topics: Buffers; China; Citrus; Electrochemistry; Electrodes; Electrophoresis, Capillary; Flavanones; Flavonoids; Fruit; Hesperidin; Hydrogen-Ion Concentration; Reproducibility of Results; Synephrine; Time Factors | 2006 |
Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids.
Topics: Animals; Fatty Acids; Flavanones; Gene Expression Regulation, Enzymologic; Hesperidin; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred ICR; Oxidation-Reduction; Peroxisomes; Random Allocation; RNA, Messenger; Up-Regulation | 2006 |
Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Citrus; Dietary Supplements; Female; Flavanones; Hesperidin; Humans; Intestinal Absorption; Male | 2007 |
Enantioseparation of some chiral flavanones using microbial cyclic beta-(1-->3),(1-->6)-glucans as novel chiral additives in capillary electrophoresis.
Topics: beta-Glucans; Bradyrhizobium; Carbohydrate Sequence; Electrophoresis, Capillary; Flavanones; Flavones; Flavonoids; Hesperidin; Hydrogen-Ion Concentration; Molecular Sequence Data; Stereoisomerism | 2007 |
Flavanone plasma pharmacokinetics from blood orange juice in human subjects.
Topics: Adult; Antioxidants; Beverages; Chromatography, High Pressure Liquid; Citrus sinensis; Cross-Over Studies; Disaccharides; Estrogen Antagonists; Female; Flavanones; Hesperidin; Humans; Intestinal Absorption; Tandem Mass Spectrometry | 2007 |
Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS.
Topics: Calibration; Chromatography, High Pressure Liquid; Citrus; Drugs, Chinese Herbal; Flavanones; Fruit; Hesperidin; Mass Spectrometry; Molecular Structure; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.
Topics: Anti-Bacterial Agents; Bacteriological Techniques; Citrus; Colony Count, Microbial; Flavanones; Flavonoids; Gram-Negative Bacteria; Gram-Positive Bacteria; Hesperidin; Microbial Sensitivity Tests; Oils, Volatile; Plant Extracts; Polygalacturonase; Saccharomyces cerevisiae | 2007 |
Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices.
Topics: Animals; Area Under Curve; Beverages; Flavanones; Fruit; Half-Life; Hesperidin; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2008 |
Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells.
Topics: Cells, Cultured; Citrus; Endothelial Cells; Flavanones; Gene Expression; Hesperidin; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Phytoestrogens; RNA, Messenger; Umbilical Veins | 2008 |
Effect of adding extracted hesperetin, naringenin and pectin on egg cholesterol, serum traits and antioxidant activity in laying hens.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Chickens; Cholesterol; Egg Yolk; Eggs; Female; Flavanones; Free Radical Scavengers; Hesperidin; Lipid Metabolism; Pectins; Random Allocation; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triglycerides | 2008 |
Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Drugs, Chinese Herbal; Flavanones; Hesperidin; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Inhibition of oral carcinogenesis by citrus flavonoids.
Topics: Animals; Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Citrus; Cricetinae; Flavanones; Flavones; Flavonoids; Hesperidin; Mouth Neoplasms; Random Allocation | 2008 |
Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin.
Topics: 3T3-L1 Cells; Adiponectin; Animals; Base Sequence; Citrus; DNA Primers; Dose-Response Relationship, Drug; Flavanones; Hesperidin; Mice; PPAR alpha; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Up-Regulation | 2008 |
Citrus fruit flavonoids influence on neutrophil apoptosis and oxidative metabolism.
Topics: Analysis of Variance; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Caspase 3; Cell Survival; Cells, Cultured; Citrus; Flavanones; Hesperidin; Humans; Luminescence; Luminol; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 2008 |
Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.
Topics: Diosmin; Drug Stability; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Hesperidin; Humans; Linear Models; Male; Oxidation-Reduction; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Enantiomeric separation of some flavanones using shinorhizobial linear octasaccharides in CE.
Topics: Animals; Electrophoresis, Capillary; Flavanones; Flavones; Flavonoids; Hesperidin; Isomerism; Oligosaccharides; Polysaccharides, Bacterial; Sinorhizobium meliloti; Temperature | 2008 |
Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes.
Topics: Adipocytes; Adipogenesis; Apoptosis; Cell Differentiation; Cell Division; Cell Line; Flavanones; Hesperidin; Humans | 2008 |
Antagonistic interactions between the flavonoids hesperetin and naringenin and beta-lactam antibiotics against Staphylococcus aureus.
Topics: Cefoxitin; Drug Interactions; Flavanones; Flavonoids; Hesperidin; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Monobactams; Penicillins; Species Specificity | 2008 |
Untargeted metabolite analysis of healthy and Huanglongbing-infected orange leaves by CE-DAD.
Topics: Citrus sinensis; Electrophoresis, Capillary; Flavanones; Hesperidin; Metabolomics; Plant Diseases; Plant Extracts; Plant Leaves; Quercetin | 2009 |
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.
Topics: Animals; Cells, Cultured; Coculture Techniques; Flavanones; Hesperidin; Inflammation; Interferon-gamma; Lipopolysaccharides; Mice; Neuroglia; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; STAT1 Transcription Factor | 2009 |
Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.
Topics: Citrus; Flavanones; Flavonoids; Fruit; Glycosides; Hesperidin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular | 2009 |
Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions.
Topics: Capsules; Chemistry, Pharmaceutical; Diffusion; Drug Compounding; Drug Delivery Systems; Drug Stability; Excipients; Flavanones; Hesperidin; Hot Temperature; Kinetics; Models, Chemical; Nanotechnology; Pharmaceutic Aids; Povidone; Solubility; Suspensions; Tablets; Time Factors; Water | 2010 |
Structural activity relationship of flavonoids with estrogen-related receptor gamma.
Topics: Apigenin; Flavanones; Flavonoids; Genistein; Heat-Shock Proteins; HeLa Cells; Hesperidin; Humans; Isoflavones; Luteolin; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Estrogen; Structure-Activity Relationship; Transcription Factors; Transcriptional Activation | 2010 |
Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.
Topics: Administration, Oral; Adult; Animals; Area Under Curve; Asian People; Chromatography, High Pressure Liquid; Citrus; Citrus sinensis; Cricetinae; Cricetulus; Flavanones; Hesperidin; Humans; Male; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome Protein | 2010 |
The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Citrus; Fatty Acids, Nonesterified; Flavanones; Flavonoids; Hesperidin; Insulin Resistance; Lipolysis; Mice; Tumor Necrosis Factor-alpha | 2010 |
Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.
Topics: Adult; Beverages; Biological Availability; Chromatography, High Pressure Liquid; Citrus sinensis; Cross-Over Studies; Female; Flavanones; Fruit; Hesperidin; Humans; Intestinal Absorption; Male; Solubility | 2010 |
Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.
Topics: Animals; Anthraquinones; Area Under Curve; Biphenyl Compounds; Chromatography, Liquid; Drugs, Chinese Herbal; Emodin; Female; Flavanones; Hesperidin; Lignans; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2010 |
Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.
Topics: Animals; Brugia malayi; Coloring Agents; Disease Models, Animal; Elephantiasis, Filarial; Female; Filaricides; Flavanones; Flavonoids; Gerbillinae; Hesperidin; Humans; Male; Murinae; Rutin; Survival Analysis; Tetrazolium Salts; Thiazoles | 2010 |
Protective effects of silybin and analogues against X-ray radiation-induced damage.
Topics: Antioxidants; DNA; DNA Breaks, Single-Stranded; DNA Damage; Dose-Response Relationship, Radiation; Electrophoresis, Agar Gel; Flavanones; Hesperidin; Models, Chemical; Molecular Structure; Plasmids; Silybin; Silymarin | 2010 |
Synergistic and antagonistic interactions of phenolic compounds found in navel oranges.
Topics: Antioxidants; Cinnamates; Citrus sinensis; Flavanones; Flavonoids; Fruit; Hesperidin; Models, Chemical; Osmolar Concentration; Oxidation-Reduction; Phenols; Polyphenols | 2010 |
NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs.
Topics: Chemistry, Pharmaceutical; Excipients; Flavanones; Flurbiprofen; Glucosides; Hesperidin; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Spectroscopy; Micelles; Models, Chemical; Molecular Structure; Pharmaceutical Preparations; Solubility; Surface Tension; Technology, Pharmaceutical; Water | 2011 |
Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogenicity Tests; Cell Transformation, Neoplastic; Epstein-Barr Virus Infections; Flavanones; Genistein; Herpesvirus 4, Human; Hesperidin; Isoflavones; Mice; Oleanolic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2011 |
Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7.
Topics: Apigenin; Aromatase; Aromatase Inhibitors; Breast Neoplasms; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Enzyme Assays; Female; Flavanones; Genes, Reporter; Hesperidin; Humans; Luciferases, Firefly; Luteolin; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Transcription Factor AP-1; Transcription, Genetic | 2011 |
Analysis of flavonoids by capillary zone electrophoresis with electrokinetic supercharging.
Topics: Clematis; Electrophoresis, Capillary; Flavanones; Flavonoids; Hesperidin; Sensitivity and Specificity; Taurine | 2011 |
Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Flavanones; Fruit; Glucosides; Hesperidin; Male; Rats; Rats, Wistar; Reference Standards; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
[Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration].
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Glucosides; Glycyrrhizic Acid; Hesperidin; Hydroxylation; Male; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Interaction of antioxidant flavonoids with calf thymus DNA analyzed by spectroscopic and electrochemical methods.
Topics: Antioxidants; Circular Dichroism; DNA; Electrochemical Techniques; Ethidium; Flavanones; Fluorescence Polarization; Hesperidin; Intercalating Agents; Molecular Structure; Nucleic Acid Conformation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectrum Analysis; Thermodynamics; Transition Temperature | 2012 |
Protective effects of fermented Citrus unshiu peel extract against ultraviolet-A-induced photoageing in human dermal fibrobolasts.
Topics: beta-Galactosidase; Cells, Cultured; Citrus; Collagen; Dermis; Disaccharides; Fermentation; Fibroblasts; Flavanones; Fruit; Hesperidin; Humans; Matrix Metalloproteinase 1; Plant Extracts; Schizophyllum; Skin Aging; Ultraviolet Rays | 2012 |
Anti-degranulating activity in rat basophil leukemia RBL-2H3 cells of flavanone glycosides and their aglycones in citrus fruits.
Topics: Animals; Anti-Allergic Agents; Basophil Degranulation Test; Basophils; Calcium; Calcium Ionophores; Cell Degranulation; Cell Line, Tumor; Citrus; Disaccharides; Dose-Response Relationship, Drug; Flavanones; Glycosides; Hesperidin; Intracellular Signaling Peptides and Proteins; Leukemia; Phosphorylation; Plant Extracts; Plants, Medicinal; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; src-Family Kinases; Syk Kinase | 2013 |
Pharmacokinetics of hesperetin and naringenin in the Zhi Zhu Wan, a traditional Chinese medicinal formulae, and its pharmacodynamics study.
Topics: Administration, Oral; Animals; Atractylodes; Chromatography, Liquid; Citrus; Drugs, Chinese Herbal; Flavanones; Gastrointestinal Motility; Hesperidin; Intestines; Male; Mice; Mice, Inbred ICR; Plasma; Tandem Mass Spectrometry | 2013 |
Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.
Topics: Animals; Benzoin; Calcium; Calcium Channel Blockers; Calcium Signaling; Citrus; Drug Evaluation, Preclinical; Fabaceae; Flavanones; Ganglia, Spinal; HEK293 Cells; Hesperidin; Humans; Membrane Potentials; Mice; Mice, Inbred C57BL; Pregnenolone; Rats; Rats, Wistar; Secondary Metabolism; TRPM Cation Channels | 2013 |
Assessment of phytochemical content in human milk during different stages of lactation.
Topics: Adult; Carotenoids; Catechin; Cryptoxanthins; Female; Flavanones; Flavonoids; Hesperidin; Humans; Kaempferols; Lactation; Lutein; Lycopene; Milk, Human; Postpartum Period; Pregnancy; Quercetin; Time Factors; Xanthophylls; Zeaxanthins | 2013 |
Flavanone metabolites decrease monocyte adhesion to TNF-α-activated endothelial cells by modulating expression of atherosclerosis-related genes.
Topics: Atherosclerosis; Cell Adhesion; Endothelial Cells; Flavanones; Gene Expression Profiling; Gene Expression Regulation; Glucuronides; Hesperidin; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Monocytes; Sulfates; Tumor Necrosis Factor-alpha | 2013 |
Simplified miniaturized ultrasound-assisted matrix solid phase dispersion extraction and high performance liquid chromatographic determination of seven flavonoids in citrus fruit juice and human fluid samples: hesperetin and naringenin as biomarkers.
Topics: Beverages; Biomarkers; Chromatography, High Pressure Liquid; Citrus; Female; Flavanones; Fruit; Hesperidin; Humans; Limit of Detection; Male; Miniaturization; Solid Phase Extraction; Sound | 2013 |
Antimicrobial effect of 7-O-butylnaringenin, a novel flavonoid, and various natural flavonoids against Helicobacter pylori strains.
Topics: Anti-Bacterial Agents; Flavanones; Flavonoids; Helicobacter pylori; Hesperidin; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Urease | 2013 |
Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
Topics: beta-Glucosidase; Citrus; Detergents; Disaccharides; Flavanones; Flavonoids; Food Industry; Glycosides; Hesperidin; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Plant Extracts; Pyrococcus furiosus; Solvents; Substrate Specificity; Temperature | 2013 |
Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis.
Topics: Animals; Biological Transport; Citrus; Diabetes Mellitus, Type 2; Flavanones; Gluconeogenesis; Glucose; Hesperidin; Hyperglycemia; Hypoglycemic Agents; Liver; Mitochondria; Phytotherapy; Plant Extracts; Pyruvic Acid; Rats; Rats, Wistar; Structure-Activity Relationship | 2014 |
Citrus flavanones affect hepatic fatty acid oxidation in rats by acting as prooxidant agents.
Topics: Animals; Antioxidants; Citrus; Flavanones; Hepatocytes; Hesperidin; Humans; Lipid Metabolism; Liver; Male; Mitochondria, Liver; Oxidation-Reduction; Peroxisomes; Rats; Reactive Oxygen Species | 2013 |
Protective effect of hesperetin and naringenin against apoptosis in ischemia/reperfusion-induced retinal injury in rats.
Topics: Animals; Apoptosis; Flavanones; Hesperidin; Male; Rats; Rats, Wistar; Reperfusion Injury; Retina | 2014 |
[Effect of different compatibility of zhizi dahuang decoction on pharmacokinetics of naringenin and hesperetin].
Topics: Animals; Chromatography, High Pressure Liquid; Citrus; Drug Incompatibility; Drug Interactions; Drugs, Chinese Herbal; Flavanones; Gardenia; Hesperidin; Rats; Rats, Sprague-Dawley | 2014 |
Orange juice (poly)phenols are highly bioavailable in humans.
Topics: Adult; Beverages; Biological Availability; Body Mass Index; Chromatography, High Pressure Liquid; Citrus sinensis; Colon; Cross-Over Studies; Female; Flavanones; Fruit; Gas Chromatography-Mass Spectrometry; Glucuronides; Healthy Volunteers; Hesperidin; Humans; Limit of Detection; Linear Models; Male; Middle Aged; Polyphenols; Retrospective Studies; Young Adult | 2014 |
In vitro colonic catabolism of orange juice (poly)phenols.
Topics: Adult; Beverages; Chromatography, High Pressure Liquid; Citrus sinensis; Colon; Coumaric Acids; Feces; Female; Fermentation; Flavanones; Gas Chromatography-Mass Spectrometry; Hesperidin; Humans; In Vitro Techniques; Male; Polyphenols | 2015 |
Effects of the flavanone combination hesperetin-naringenin, and orange and grapefruit juices, on airway inflammation and remodeling in a murine asthma model.
Topics: Airway Remodeling; Animals; Asthma; Beverages; Bronchoalveolar Lavage Fluid; Citrus paradisi; Citrus sinensis; Disease Models, Animal; Eosinophils; Flavanones; Fruit; Hesperidin; Inflammation; Lung; Macrophages; Male; Mice; Mice, Inbred BALB C | 2015 |
Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women.
Topics: Adult; Aged; Aged, 80 and over; Caffeic Acids; Case-Control Studies; Catechin; Coumaric Acids; Diabetes Mellitus, Type 2; Female; Flavanones; Follow-Up Studies; Hesperidin; Humans; Hydroxybenzoates; Middle Aged; Nutrition Assessment; Polyphenols; Prospective Studies; Quercetin; Risk Factors; Surveys and Questionnaires | 2015 |
Effect of Mannitol on Nucleation and Crystal Growth of Amorphous Flavonoids: Implications on the Formation of Nanocrystalline Solid Dispersion.
Topics: Calorimetry, Differential Scanning; Crystallization; Excipients; Flavanones; Hesperidin; Kinetics; Mannitol; Phase Transition; Powder Diffraction; Thermodynamics; X-Ray Diffraction | 2015 |
Pharmacokinetic interaction study between flavanones (hesperetin, naringenin) and rasagiline mesylate in wistar rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cytochrome P-450 CYP1A2; Drug Interactions; Flavanones; Hesperidin; Indans; Male; Monoamine Oxidase Inhibitors; Rats, Wistar; Spinal Cord; Tissue Distribution | 2016 |
Copper(II) complexes with naringenin and hesperetin: cytotoxic activity against A 549 human lung adenocarcinoma cells and investigation on the mode of action.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Coordination Complexes; Copper; DNA; Fibroblasts; Flavanones; Hesperidin; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms | 2016 |
Biotransformation effects on anti lipogenic activity of citrus extracts.
Topics: Adipocytes; Animals; Citrus; Flavanones; Hesperidin; Lipolysis; Mice; Plant Extracts | 2016 |
Simultaneous Chiral Separation of Flavanone, Naringenin, and Hesperetin Enantiomers by RP-UHPLC-DAD.
Topics: Amylose; Chromatography, High Pressure Liquid; Flavanones; Hesperidin; Molecular Structure; Phenylcarbamates; Stereoisomerism | 2016 |
Chemical Evidence for Potent Xanthine Oxidase Inhibitory Activity of Ethyl Acetate Extract of Citrus aurantium L. Dried Immature Fruits.
Topics: Acetates; Citrus; Enzyme Inhibitors; Flavanones; Flavones; Fruit; Hesperidin; Humans; Hyperuricemia; In Vitro Techniques; Molecular Structure; Phytotherapy; Plant Extracts; Xanthine Oxidase | 2016 |
Effect of thermal processing on the profile of bioactive compounds and antioxidant capacity of fermented orange juice.
Topics: Antioxidants; Ascorbic Acid; Carotenoids; Citrus sinensis; Evaluation Studies as Topic; Fermentation; Flavanones; Flavonoids; Food Handling; Fruit; Fruit and Vegetable Juices; Glucosides; Hesperidin; Hot Temperature; Pasteurization; Phenols; Provitamins; Vitamin A | 2016 |
Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors.
Topics: Cell Cycle; Cell Line, Tumor; Flavanones; Genes, erbB-2; Hesperidin; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases | 2016 |
Development and validation of a RP-UHPLC-ESI-MS/MS method for the chiral separation and determination of flavanone, naringenin and hesperetin enantiomers.
Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Flavanones; Hesperidin; Reproducibility of Results; Tandem Mass Spectrometry | 2016 |
Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats.
Topics: Aging; Animals; Antioxidants; Citrus; Flavanones; Gene Expression; Hesperidin; Lipid Peroxidation; Liver; Male; Oxidative Stress; Phospholipids; Plant Oils; Rats; Rats, Wistar; Sunflower Oil; Thiobarbituric Acid Reactive Substances | 2016 |
Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus.
Topics: Bifidobacterium longum; Citrus sinensis; Flavanones; Fruit; Fruit and Vegetable Juices; Glucosidases; Hesperidin; Intestinal Absorption; Lacticaseibacillus rhamnosus; Probiotics | 2018 |
Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions.
Topics: Animals; Cell Line; Citrus; Flavanones; Glucuronosyltransferase; Herb-Drug Interactions; Hesperidin; Humans; Hymecromone; Insecta; Recombinant Proteins; Trifluoperazine | 2016 |
Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice.
Topics: Animals; Cells, Cultured; Citrus paradisi; Computer Simulation; Dogs; Estrone; Flavanones; Flavones; Food-Drug Interactions; Fruit and Vegetable Juices; Furocoumarins; Hesperidin; Humans; Inhibitory Concentration 50; Models, Biological; Organic Anion Transporters | 2017 |
Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis.
Topics: Acute Disease; Alanine Transaminase; Animals; Anthraquinones; Aspartate Aminotransferases; Biphenyl Compounds; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Emodin; Flavanones; Hesperidin; Inflammation; Lignans; Liver; Male; Pancreatitis; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2017 |
Urinary metabolite profiling of flavonoids in Chinese volunteers after consumption of orange juice by UFLC-Q-TOF-MS/MS.
Topics: Adult; China; Chromatography, High Pressure Liquid; Citrus sinensis; Female; Flavanones; Flavonoids; Fruit and Vegetable Juices; Hesperidin; Humans; Male; Tandem Mass Spectrometry; Young Adult | 2017 |
The acute effects of citrus flavanones on the metabolism of glycogen and monosaccharides in the isolated perfused rat liver.
Topics: Adenosine Diphosphate; Animals; Citrus; Energy Metabolism; Flavanones; Flavones; Fructose; Glucose; Glycogenolysis; Hesperidin; In Vitro Techniques; Liver; Liver Glycogen; Male; Monosaccharides; Oxygen Consumption; Perfusion; Rats; Rats, Wistar | 2018 |
In Silico Docking and In Vitro Approaches towards BACE1 and Cholinesterases Inhibitory Effect of Citrus Flavanones.
Topics: Acetylcholinesterase; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Citrus; Enzyme Assays; Flavanones; GPI-Linked Proteins; Hesperidin; Humans; Kinetics; Molecular Docking Simulation; Neuroprotective Agents; Nootropic Agents; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Thermodynamics | 2018 |
Pharmacokinetic study of the prokinetic ABCs liquiritigenin, naringenin and hesperitin following the oral administration of Si-Ni-San decoction to functional dyspepsia patients.
Topics: Administration, Oral; Adult; Chromatography, Liquid; Drugs, Chinese Herbal; Dyspepsia; Female; Flavanones; Gastrointestinal Motility; Hesperidin; Humans; Male; Middle Aged; Sulfamethoxazole | 2019 |
Sulfation of hesperetin, naringenin and apigenin by the human cytosolic sulfotransferases: a comprehensive analysis.
Topics: Apigenin; Cell Line, Tumor; Cytosol; Flavanones; Hesperidin; Humans; Intestinal Mucosa; Kidney; Liver; Lung; Metabolic Networks and Pathways; Sulfates; Sulfotransferases | 2020 |
Combined administration of naringenin and hesperetin with optimal ratio maximizes the anti-cancer effect in human pancreatic cancer via down regulation of FAK and p38 signaling pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Citrus; Down-Regulation; Flavanones; Focal Adhesion Kinase 1; Hesperidin; Humans; MAP Kinase Signaling System; Mice, Inbred BALB C; Pancreatic Neoplasms; Phosphorylation; Xenograft Model Antitumor Assays | 2019 |
Urinary flavanone concentrations as biomarkers of dietary flavanone intakes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Topics: Biomarkers; Citrus sinensis; Diet; Europe; Female; Flavanones; Hesperidin; Humans; Male; Middle Aged; Nutrition Assessment; Nutrition Surveys | 2020 |
Quantitative analysis of multicomponents by single marker combined with HPLC fingerprint qualitative analyses for comprehensive evaluation of Aurantii Fructus.
Topics: Chromatography, High Pressure Liquid; Citrus; Coumarins; Disaccharides; Flavanones; Flavones; Flavonoids; Fruit; Hesperidin | 2020 |
Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Flavanones; Half-Life; Hesperidin; Limit of Detection; Male; Rats; Rats, Wistar; Reproducibility of Results; ROC Curve; Tandem Mass Spectrometry | 2020 |
Estimated dietary polyphenol intake and major food sources of the Brazilian population.
Topics: Beverages; Brazil; Chlorogenic Acid; Cross-Sectional Studies; Diet; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Polyphenols | 2021 |
Urinary Biomarkers for Orange Juice Consumption.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Citrus sinensis; Female; Flavanones; Fruit and Vegetable Juices; Hesperidin; Humans; Limit of Detection; Male; Phloretin; Proline; Reproducibility of Results; Synephrine; Tandem Mass Spectrometry; Urinalysis; Young Adult | 2021 |
Inhibition of histone acetyltransferase by naringenin and hesperetin suppresses Txnip expression and protects pancreatic β cells in diabetic mice.
Topics: Acetylation; Animals; Carrier Proteins; Citrus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Flavanones; Hesperidin; Histone Acetyltransferases; Histones; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Rats; Thioredoxins | 2021 |
Polyphenols from Citrus Tacle
Topics: Citrus; Dietary Supplements; Enzyme Inhibitors; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Models, Molecular; Molecular Docking Simulation; Plant Extracts; Polyphenols; Protein Binding; Protein Conformation | 2021 |
Production of hesperetin from naringenin in an engineered Escherichia coli consortium.
Topics: Escherichia coli; Flavanones; Hesperidin | 2022 |