hesperidin has been researched along with methotrexate in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Rovenská, E; Rovenský, J; Stancíková, M; Stvrtinová, V; Svík, K | 1 |
| Rovenská, E; Rovenský, J; Stancíková, M; Stvrtina, S; Stvrtinová, V; Svík, K | 1 |
| Acipayam, C; Bayram, I; Daglioglu, K; Doran, F; Ozkan, A; Sezgin, G; Tanyeli, A; Totan Ateş, B; Yilmaz, S | 1 |
| Di, T; Li, N; Li, P; Li, X; Liu, Z; Meng, Y; Wang, M; Xie, X; Zhai, C; Zhang, L | 1 |
| Chaisawang, P; Naewla, S; Pannangrong, W; Sirichoat, A; Welbat, JU; Wigmore, P | 1 |
| Abdelazem, AZ; Abdelaziz, RM; Attia, YA; Hashem, KS | 1 |
| Aranarochana, A; Naewla, S; Pannangrong, W; Sirichoat, A; Welbat, JU; Wigmore, P | 1 |
| Abo-Youssef, AM; Hassan, MIA; Hemeida, RAM; Osman, AT; Sharkawi, SMZ | 2 |
| Aranarochana, A; Naewla, S; Prajit, R; Sirichoat, A; Sritawan, N; Suwannakot, K; Welbat, JU; Wigmore, P | 1 |
12 other study(ies) available for hesperidin and methotrexate
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Bone Density; Diosmin; Drug Combinations; Edema; Hesperidin; Male; Methotrexate; Nitrates; Nitrites; Plethysmography; Rats; Serum Albumin; Severity of Illness Index | 2008 |
Treatment of rat adjuvant arthritis with flavonoid (Detralex), methotrexate, and their combination.
Topics: Animals; Arthritis, Experimental; Diosmin; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Hesperidin; Hindlimb; Immunosuppressive Agents; Male; Methotrexate; Nitrates; Nitrites; Rats; Rats, Inbred Lew; Serum Albumin; Treatment Outcome | 2009 |
The protective effect of hesperidin on methotrexate-induced intestinal epithelial damage in rats: an experimental study.
Topics: Animals; Antineoplastic Agents; Gastrointestinal Agents; Hesperidin; Interleukin-8; Intestinal Mucosa; Intestine, Small; Ki-67 Antigen; Male; Methotrexate; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar | 2014 |
Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway.
Topics: Animals; Blotting, Western; Cell Proliferation; Dermatologic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Hesperidin; Humans; Imiquimod; Keratinocytes; Lipopolysaccharides; Male; MAP Kinase Signaling System; Methotrexate; Mice; Mice, Inbred BALB C; Psoriasis; Real-Time Polymerase Chain Reaction | 2019 |
Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats.
Topics: Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Doublecortin Protein; Enzyme Inhibitors; Hesperidin; Hippocampus; Male; Memory Disorders; Methotrexate; Neurogenesis; Neurons; Rats; Rats, Sprague-Dawley | 2019 |
Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Hesperidin; Inflammation Mediators; Liver; Male; Methotrexate; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Signal Transduction; Tumor Suppressor Protein p53 | 2020 |
Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat.
Topics: Animals; Antimetabolites, Antineoplastic; Doublecortin Protein; Hesperidin; Male; Methotrexate; Neurogenesis; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2020 |
RETRACTED: Empagliflozin and neohesperidin mitigate methotrexate hepatotoxicity via Nrf2/PPARγ/HO-1 signalling initiation and suppression of NF-κB/Keap1/HSP70/caspase-3 axis in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Benzhydryl Compounds; Caspase 3; Chemical and Drug Induced Liver Injury; Glucosides; Heme Oxygenase (Decyclizing); Hesperidin; HSP72 Heat-Shock Proteins; Kelch-Like ECH-Associated Protein 1; Male; Methotrexate; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Protective Agents; Rats; Signal Transduction | 2021 |
Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats.
Topics: Acetylcysteine; Animals; Benzhydryl Compounds; Glucosides; Hesperidin; Inflammation; Kidney; Kidney Diseases; Male; Methotrexate; Oxidative Stress; Protective Agents; Rats; Signal Transduction | 2021 |
Hesperidin ameliorates impairment in hippocampal neural stem cells related to apoptosis induced by methotrexate in adult rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Disks Large Homolog 4 Protein; Hesperidin; Hippocampus; Ki-67 Antigen; Methotrexate; Nestin; Neural Stem Cells; Rats | 2023 |