Page last updated: 2024-08-21

hesperidin and hesperetin

hesperidin has been researched along with hesperetin in 509 studies

Research

Studies (509)

TimeframeStudies, this research(%)All Research%
pre-19905 (0.98)18.7374
1990's15 (2.95)18.2507
2000's86 (16.90)29.6817
2010's285 (55.99)24.3611
2020's118 (23.18)2.80

Authors

AuthorsStudies
Ash, K; Grohmann, K; Manthey, CL; Manthey, JA; Montanari, A1
Bailey, DG; Dawson, PA; Dresser, GK; Freeman, DJ; Kim, RB; Leake, BF; Schwarz, UI1
Bronze, MR; Mendes, T; Serra, H; Simplício, AL1
Amić, D; Lucić, B1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Bijak, M; Krotkiewski, H; Nowak, P; Pawlaczyk, I; Ponczek, M; Saluk, J; Wachowicz, B; Ziewiecki, R1
Han, C; Kong, L; Lei, J; Li, S; Liu, C; Peng, W; Wang, Z; Xu, X1
Cubo, MT; Downie, JA; Economou, A; Johnston, AW; Murphy, G1
Chauvaux, N; De Greef, J; John, M; Prinsen, E; Schell, J; Schmidt, J; Van Onckelen, H; Wieneke, U1
'T Hart, BA; Ip Via Ching, TR; Labadie, RP; Van Dijk, H1
Guengerich, FP; Kim, DH1
Downie, JA; Economou, A; Hamilton, WD; Surin, BP; Watson, JM1
Downie, JA; Economou, A; Hawkins, FK; Johnston, AW1
Kaul, TN; Middleton, E; Ogra, PL1
Kroyer, G1
Middleton, E; Vladutiu, GD1
Bonina, F; Castelli, F; Lanza, M; Marzullo, D; Saija, A; Scalese, M1
Das, NP; Kuppusamy, UR1
Hans, B; Kramarczyk, R; Krumbiegel, G; Rickling, B; Weyhenmeyer, R1
Liehr, JG; Zhu, BT1
Chiang, CH; Chiou, GC; Liu, SX; Yao, QS1
Carroll, KK; Chambers, AF; Guthrie, N; Moussa, M; So, FV1
Balentine, DA; Conney, AH; Loder, DP; Taneja, N; Zhu, BT1
Borradaile, NM; Carroll, KK; Kurowska, EM1
Choudhury, R; Chowrimootoo, G; Debnam, ES; Rice-Evans, C; Spencer, JP; Srai, SK1
Burke, MD; Doostdar, H; Mayer, RT1
Johnson, MK; Loo, G1
Alfthan, G; Aro, A; Erlund, I; Meririnne, E1
Ji, HT; Qian, DH; Wang, JS; Zhang, JP; Zhang, M1
Borradaile, NM; de Dreu, LE; Huff, MW; Wilcox, LJ1
Tobias, CA; Yang, TC1
Anno, T; Cha, JY; Cho, YS; Kim, I; Rahman, SM; Yanagita, T1
Chovanec, P; Kropácová, M; Lisá, L; Nemcová, M; Novák, K; Skrdleta, V1
Aromaa, A; Hakulinen, T; Heliövaara, M; Järvinen, R; Knekt, P; Kumpulainen, J; Reunanen, A; Rissanen, H1
Alfthan, G; Aro, A; Erlund, I; Kesäniemi, YA; Rantala, M; Silaste, ML1
Fujisaw, S; Ishihara, M; Kadoma, Y1
Choi, MS; Jeong, TS; Kim, HK; Lee, MK; Park, YB1
Alzuru, M; Mendez, J; Paredes, A; Rodríguez-Ortega, M1
Abbott, NJ; Dobbie, MS; Kuhnle, G; Proteggente, AR; Rice-Evans, C; Youdim, KA1
Chen, FM; Li, ZC; Zhou, YJ1
Duh, PD; Huang, SL; Tsai, HL; Yen, GC1
Bok, SH; Jeong, TS; Kim, EE; Lee, CH; Lee, S; Lee, WS; Moon, SS; Oh, GT; Oh, JH1
Chen, YC; Lin, HY; Shen, SC2
de la Rocha, NE; Guardia, T; Juárez, AO; Pelzer, LE; Rotelli, AE1
Basu-Modak, S; Gordon, MJ; Kuhnle, G; Proteggente, AR; Rice-Evans, CA; Tyrrell, R; Youdim, K1
Georgarakis, M; Kanaze, FI; Kokkalou, E; Niopas, I1
Arcas, MC; Baidez, AG; Botía, JM; del Río, JA; Gómez, P; Ortuño, A1
Lu, Y; Wu, C; Yuan, Z1
Choi, SH; Kim, DH; Lee, NK; Park, EK; Park, SH1
Choi, JS; Chung, HY; Jung, KJ; Kim, JY2
Benjamin, MM; Gallard, H; Korshin, GV; Lu, J1
Erb, A; Kraus, M; Labib, S; Richling, E; Wickert, T1
Daugherty, A; Kurowska, EM; Manthey, JA; Whitman, SC1
Alvarez, E; Basaran, H; Lugnier, C; Orallo, F1
Davies, NM; Roupe, KA; Teng, XW; Yáñez, JA1
Wang, YD; Xie, MX; Xu, XY1
Liu, F; Peng, Y; Ye, J; Yuan, J1
Choi, YJ; Jeong, YJ; Kang, SW; Kang, YH; Kwon, HM; Lee, M; Park, HS1
Besson, C; Manach, C; Mathevon, T; Morand, C; Remesy, C; Scalbert, A; Silberberg, M1
Calabrò, ML; Catania, S; Costa, C; Donato, P; Ficarra, P; Ficarra, R; Stancanelli, R; Tommasini, S; Villari, V1
Chao, PD; Ho, TY; Hsieh, CC; Lai, CC; Lin, CW; Tsai, CH; Tsai, FJ; Wan, L1
Huong, DT; Ide, T; Takahashi, Y1
Dimpfel, W1
Fukumoto, S; Hiramitsu, M; Kondo, K; Miyake, Y; Osawa, T; Sakaida, K; Sakurai, C; Usuda, M1
Chee, KM; Choi, EJ; Kim, GD; Kim, GH1
Pollard, SE; Spencer, JP; Whiteman, M1
Bauer, A; Greten, J; Karle, CA; Kathöfer, S; Katus, HA; Kiesecker, C; Kreuzer, J; Remppis, A; Scholz, EP; Thomas, D; Zitron, E1
Cho, J1
Bounartzi, MI; Georgarakis, M; Kanaze, FI; Niopas, I1
Chung, JH; Han, XH; Jin, YR; Lee, JJ; Lim, Y; Yun, YP; Zhang, YH1
Jung, S; Kwon, C; Park, H1
Gardana, C; Guarnieri, S; Porrini, M; Riso, P; Simonetti, P1
Jing, Y; Liang, XM; Xu, Q; Xue, XY; Zhang, FF; Zhou, DY1
Choi, EM; Kim, YH1
Choi, EJ2
Han, XH; Jin, YR; Kim, TJ; Lee, JJ; Lim, Y; Yoo, HS; Yun, YP; Zhang, YH1
Kobayashi, S; Konishi, Y; Sugiyama, M; Tanabe, S1
Bennett, RN; Bisignano, G; Faulds, CB; Gasson, MJ; Mandalari, G; Narbad, A; Saija, A; Trombetta, D1
Andrews, PK; Davies, NM; Miranda, ND; Remsberg, CM; Vega-Villa, KR; Yáñez, JA1
Hamada, H; Shimoda, K2
Cheng, YY; Liu, L; Xu, DM1
Bhatnagar, A; Kaiserova, K; Srivastava, S; Tang, XL1
Lien, TF; Su, WT; Yeh, HS1
Liu, Y; Song, R; Tian, Y; Xu, F; Zhang, Z1
Hase, T; Suzuki, A; Yamamoto, M1
Bourland, TC; Miller, EG; Patil, BS; Peacock, JJ; Taylor, SE; Wright, JM1
Bahia, P; Fahmi, A; Rainey-Smith, S; Rattray, M; Rice-Evans, C; Schroetke, LW; Skilton, R; Spencer, JP; Williams, RJ1
Barron, D; Brand, W; Rein, MJ; Rietjens, IM; van Bladeren, PJ; van der Wel, PA; Williamson, G1
Davis, JW; Holland, LJ; Manthey, JA; Morin, B; Nichols, LA; Zalasky, KM1
Aranganathan, S; Nalini, N; Panneer Selvam, J1
Cheng, YY; Liu, L; Lu, XP; Ning, ZQ; Shan, S; Zhang, K1
Aranganathan, S; Nalini, N; Selvam, JP1
Kasmas, S; Niopas, I; Spanakis, M1
Jung, S; Kwon, C; Paik, SR1
Hanada, H; Handa, K; Hirota, K; Mochizuki, H; Morikawa, K; Nonaka, M1
Denny, BJ; Mathew, TC; West, PW1
Barreca, D; Bellocco, E; Ficarra, S; Galtieri, A; Kotyk, A; Laganà, G; Leuzzi, U; Tellone, E1
Ahn, WS; Choi, EJ1
Al Shaal, L; Keck, CM; Mishra, PR; Müller, RH2
Chen, G; Chen, Y; Huang, C; Zhou, T1
Huang, XY; Song, B; Zeng, YY; Zhou, YY1
Coxam, V; Davicco, MJ; Demigne, C; Habauzit, V; Horcajada, MN; Lebecque, P; Mercier, S; Trzeciakiewicz, A1
Lee, HY; Rodriguez-Mateos, A; Spencer, JP; Vafeiadou, K; Vauzour, D; Williams, RJ1
Aranganathan, S; Nalini, N; Sangeetha, N; Selvam, JP1
De Luca, G; Di Donna, L; Mazzotti, F; Napoli, A; Salerno, R; Sindona, G; Taverna, D1
Li, Y; Wang, MF; Yang, ZY1
Maiti, K; Mukherjee, K; Mukherjee, PK; Murugan, V; Saha, BP1
Aranganathan, S; Nalini, N2
Barmpalexis, P; Bikiaris, D; Georgarakis, E; Kanaze, FI; Kokkalou, E; Niopas, I1
Aturki, Z; Badjah-Hadj-Ahmed, AY; D'Orazio, G; Fanali, S; Rocco, A; Si-Ahmed, K; Tazerouti, F1
Fang, F; Huang, Z; Wang, J; Wong, CW1
Barron, D; Habauzit, V; Horcajada, MN; Manach, C; Mercier, S; Offord, E; Trzeciakiewicz, A; Urpi-Sarda, M1
Barron, D; Bik, H; Boersma, MG; Brand, W; Glatt, H; Hoek-van den Hil, EF; Meinl, W; Rietjens, IM; van Bladeren, PJ; Vervoort, J; Williamson, G1
Huang, CT; Huang, YB; Lee, KF; Tsai, YH; Wu, PC2
Barron, D; Bouisset, F; Bredsdorff, L; Cornett, C; Nielsen, IL; Offord, E; Rasmussen, SE; Williamson, G1
Brand, W; Padilla, B; Rietjens, IM; van Bladeren, PJ; Williamson, G1
Bredsdorff, L; Haraldsdóttir, J; Knuthsen, P; Krogholm, KS; Rasmussen, SE1
Cao, H; Chen, X; Lv, H; Sakurai, T; Sun, H; Sun, W; Wang, X; Zhou, J1
Al Shaal, L; Keck, CM; Müller, RH1
Kai, H; Kawai, K; Ogata, K; Shuto, T; Takamura, N; Tokunaga, J; Yoshida, H1
Breccia, JD; Mazzaferro, L; Minig, M; Piñuel, L1
Boza, J; Cerdá, B; Escudero, E; Espín, JC; García-Conesa, MT; Larrosa, M; Tomás-Barberán, FA; Vallejo, F; Zafrilla, MP1
Brand, W; de Haan, LH; Dionisi, F; Hoek-van den Hil, EF; Rein, MJ; Rietjens, IM; Shao, J; Spenkelink, B; van Bladeren, PJ; van Elk, KN; Williamson, G1
Creczynski-Pasa, T; Jaramillo, C; Lima, VR; Londoño-Londoño, J1
Dong, H; Liu, Y; Song, R; Xu, F; Zhang, Z1
Choi, EM; Lee, YS1
Cho, YY; Choi, MS; Jeon, SM; Kim, HJ; Kwon, EY; Lee, JH; Lee, MK1
Cai, L; Li, J; Li, R; Peng, L; Xie, XF1
Dube, V; Joseph, SK; Lakshmi, V; Mishra, SK; Murthy, PK; Sahoo, MK; Srivastava, S; Verma, SK1
Fu, H; Fujii, K; Hata, K; Katsumura, Y; Lin, M; Muroya, Y; Shikazono, N; Yokoya, A1
Hadjmohammadi, MR; Nazari, SS1
Bortolozzo, S; Floreani, M; Moro, S; Nassi, A; Palatini, P; Pavanetto, M; Quintieri, L; Stragliotto, S1
Han, SB; Jin, MJ; Kim, DH; Kim, IS; Kim, U; Kim, Y; Kwon, OS; Yoo, HH1
Pari, L; Shagirtha, K2
Hegde, AH; Sandhya, B; Seetharamappa, J1
Choi, EJ; Kim, GH1
Jena, GB; Tripathi, DN; Trivedi, PP1
Holland, LJ; Jackson, DE; Manthey, JA; Nichols, LA; Shukla, SD1
Chen, H; Kunnimalaiyaan, M; Pinchot, SN; Zarebczan, B1
Hwang, SL; Yen, GC1
Jena, GB; Kushwaha, S; Tripathi, DN; Trivedi, PP1
Arai, T; Hamashima, Y; Hasegawa, J; Kajimoto, T; Node, M; Suzuki, N; Tanaka, R; Tokuda, H; Tsujii, H; Yamada, T1
Chebib, M; Loscalzo, LM; Marder, M; Wasowski, C; Yow, TT1
Catania, S; Costa, C; Melchini, A; Stancanelli, R; Tommasini, S1
Leung, LK; Li, F; Lin, SM; Ye, L1
Floreani, M; Moro, S; Palatini, P; Quintieri, L1
Hussein, SZ; Makpol, S; Yusof, YA; Yusoff, KM1
Ishiduka, S; Kometani, T; Mukai, R; Takumi, H; Terao, J1
Herath, W; Khan, IA1
Actis-Goretta, L; Dionisi, F; Giuffrida, F; Lévèques, A; Rein, MJ; Williamson, G1
Breadmore, MC; Li, Y; Lu, Y; Yao, Q; Zhong, H1
Kalist, S; Leelavinothan, P1
Bi, K; Gao, J; Sun, H; Tong, L; Zhou, D; Zhu, Y1
Barron, D; Brand, W; Dionisi, F; Krajcsi, P; Oosterhuis, B; Rietjens, IM; van Bladeren, PJ; Williamson, G1
Chung, HY; Park, D; Park, YD; Qian, GY; Si, YX; Wang, SF; Wang, ZJ; Yan, L; Yang, JM; Yin, SJ1
Chen, SC; Hou, YC; Hseu, YC; Lee Chao, PD; Senthil Kumar, KJ; Tsai, SY; Yang, HL; Yu, KN1
Akbarsha, MA; Bernini, R; Menon, VP; Nalini, N; Preethy, CP; Riyasdeen, A; Sivagami, G; Vinothkumar, R1
Abubakar, S; Mustafa, MR; Sam, SS; Teoh, BT; Wong, PF; Zandi, K1
Chan, FL; Chen, S; Leung, LK; Ye, L1
Hwang, SL; Shih, PH; Yen, GC1
Hippalgaonkar, K; Majumdar, S; Srirangam, R1
Chiou, YL; Huang, YC; Liu, KC1
Harada, R; Kawai, Y; Kometani, T; Mukai, R; Murota, K; Nadamoto, T; Nakamura, H; Simizu, T; Takumi, H; Terao, J1
Bi, S; Pang, B; Wang, T; Wang, Y; Yan, L1
Hegde, AH; Prashanth, SN; Seetharamappa, J1
Huang, SM; Lin, JA; Tsai, SY; Wu, CH; Yen, GC1
Aranganathan, S; Kabalimurthy, J; Nalini, N1
Bae, JT; Kim, GB; Ko, HJ; Lee, GS; Pyo, HB1
Iinuma, M; Iio, A; Ito, M; Nozawa, Y; Ohguchi, K1
Ishihara, S; Matsuura, A; Qi, J; Sakagami, Y; Sun, K; Xiang, L1
Barraj, LM; Bi, X; Cheatham, R; Herman, D; Murphy, MM; Randolph, RK1
Hwang, SL; Lin, JA; Shih, PH; Yeh, CT; Yen, GC1
Avula, B; Hippalgaonkar, K; Khan, IA; Majumdar, S; Srirangam, R1
Iinuma, M; Masuda, M; Matsuda, H; Murata, K; Takano, S1
Alshatwi, AA; Periasamy, VS; Ramesh, E; Subash-Babu, P1
Li, D; Mitsuhashi, S; Ubukata, M1
Cai, L; Li, J; Li, R; Peng, L; Wu, TN; Xie, XF1
Boom, K; Fang, X; Ferrari, M; Shen, H; Wolfram, J; Yang, Y1
Furtado, AF; Nunes, MA; Ribeiro, MH1
Raza, MA; Shahwar, D1
Dong, T; Han, Y; Sakurai, T; Sun, H; Wang, X; Wu, X; Yan, G; Yang, J; Zhang, A1
Fang, X; Ferrari, M; Shen, H; Wolfram, J; Yang, Y1
Konrad, M; Mohr, F; Oberwinkler, J; Philipp, SE; Schaefer, M; Stab, J; Straub, I1
Ferruzzi, MG; Jouni, ZE; Song, BJ1
Chan, FL; Chen, S; Cheung, WH; Chow, S; Leung, LK; Li, F1
Jia, W; Tang, L1
Bennetau-Pelissero, C; Bérard, AM; Chanet, A; Claude, S; Kamran Khan, M; Maier, JA; Mazur, A; Milenkovic, D; Morand, C; Rakotomanomana, N; Shinkaruk, S1
Alfaro, FF; Cappellini, C; Céliz, G; Daz, M; Verstraeten, SV1
Gupta, SK; Jha, KA; Kumar, B; Nag, TC; Saxena, R; Srinivasan, BP; Srivastava, S1
Huang, C; Huang, Y; Li, HY; Li, J; Li, R; Li, RQ; Ren, DY; Xu, T1
Bian, Z; Cheng, Z; Deng, W; Fang, Y; Jiang, D; Lin, Y; Liu, Y; Pu, P; Tang, Q; Zhang, J; Zhang, R; Zhou, H1
Heo, JS; Kang, KL; Kim, SY; Lee, JC; Lee, JY; Park, YD1
Naveen Babu, K; Ravindra Babu, P; Sridhar, V; Surya Sandeep, M1
Ito, A; Norimoto, H; Okubo, T; Shin, N; Tsuchida, T1
Anandan, B; Chandra, SR; Jayaraman, G; Malathi, R; Paramasivam, A; Radha, M; Sambantham, S1
Asghari, A; Barfi, A; Barfi, B; Rajabi, M; Saeidi, I1
Breccia, JD; Guisán, JM; López-Gallego, F; Piñuel, L1
Ahn, DU; Kim, KT; Lee, JH; Moon, SH; Nah, SY; Paik, HD; Park, YS1
Bansal, AK; Khomane, KS; Shete, G1
Nam, HK; Oh, DK; Shin, KC1
Bracht, A; Constantin, J; Constantin, RP; Ishii-Iwamoto, EL; Yamamoto, NS1
Bracht, A; Constantin, J; Constantin, RP; do Nascimento, GS; Ishii-Iwamoto, EL; Salgueiro, CL; Yamamoto, NS1
Hase, T; Jokura, H; Shimotoyodome, A; Suzuki, A; Yamamoto, M1
Chen, H; Jaskula-Sztul, R; Patel, PN; Yu, XM1
Bian, Z; Dai, J; Deng, W; Li, F; Liu, Y; Tang, Q; Wu, Q; Yang, Z; Yuan, Y; Zhou, H1
Arikan, S; Ersan, I; Gencer, B; Hanci, V; Kara, S; Karaboga, I; Karaca, T; Tufan, HA1
Avery, MA; Boulos, N; Gilbertson, R; Guy, RK; Jacob, MR; Jeffries, C; Khan, IA; Li, XC; Liang, Q; Ravu, RR; Shelat, AA; Smithson, D; Tu, Y; Walker, LA; Wang, M; Wu, Y; Yang, J1
Fordham, JB; Naqvi, AR; Nares, S1
Abd-Alla, MH; Bagy, MK; Bashandy, SR; El-enany, AW1
Cui, L; Hou, X; Li, J; Liu, Y; Niu, L; Zhang, M; Zhang, X1
Gamo, K; Matsuura, N; Miyachi, H; Shiraki, T1
Cakir Gungor, AN; Cosar, E; Demirtas, S; Gencer, M; Hacivelioglu, S; Karaca, T; Korkmaz, F; Uysal, A1
Aswar, M; Aswar, U; Kute, P; Mahajan, S; Mahajan, U; Nerurkar, G1
Grigorova-Borsos, AM; Guillot, R; Jacolot, P; Kassab, I; Peyroux, J; Sternberg, M; Tessier, F; Urios, P1
Gamo, K; Matsuura, N; Miyachi, H; Nakamura, K1
Iranshahi, M; Parhiz, H; Rezaee, R; Roohbakhsh, A; Soltani, F4
Borrego, F; Tomás-Barberán, FA; Tomás-Navarro, M; Vallejo, F1
Das, PK; Kar, S; Palit, S; Sharma, G1
Feng, F; Liu, XY1
Alshatwi, AA; Subash-Babu, P1
Chen, CY; Chiu, YW; Lin, CC; Lin, YJ; Yang, CH1
Iqbal, Z; Kumar, V; Negi, LM; Singh, P; Talegaonkar, S; Tyagi, A; Verma, AK; Zafar, S1
Brodowska, K; Bujacz, A; Chruscinski, L; Cieslak, M; Garribba, E; Janicka, M; Klewicka, E; Krolewska, K; Lodyga-Chruscinska, E; Oldziej, S; Rowinska-Zyrek, M; Sykula, A; Symonowicz, M1
Deng, W; Jiao, R; Li, L; Liu, W; Liu, Y; Tang, Q1
Borges, G; Calani, L; Clifford, MN; Crozier, A; Del Rio, D; Ky, I; Pereira-Caro, G; Ribas, A; Roberts, SA1
Ansarin, K; Kolahian, S; Pour Moghaddam, M; Sakhinia, E; Sakhinia, M; Seyedrezazadeh, E; Shahbazfar, AA; Vafa, M1
Ding, F; Peng, W1
Li, C; Schluesener, H1
Aksit, H; Demirtas, I; Elmastas, M; Erenler, R; Sen, O; Telci, İ; Yaglioglu, AS1
Adelli, GR; Balguri, SP; Hingorani, T; Majumdar, S; Punyamurthula, N1
Dong, W; Song, J; Wang, J; Wu, D; Zhang, J1
Magraner-Pardo, L; Peris, JE; Taléns-Visconti, R; Usach, I1
Bansal, AK; Jain, S; Pawar, YB; Shete, G; Thanki, K1
Bedel, A; Bennetau-Pelissero, C; Bérard, AM; Constans, J; Martin, JF; Mazur, A; Morand, C; Rock, E1
Cassidy, A; Franke, AA; Hu, FB; Pan, A; Rimm, EB; Sun, Q; Townsend, MK; Tworoger, SS; van Dam, RM; Wedick, NM1
Chen, J; Huang, S; Li, K; Shao, H; Zhao, L; Zhou, H1
Gurushankar, K; Jayasree, RS; Krishnakumar, N; Nazeer, SS1
Dong, W; Song, J; Wang, J; Wu, D; Yi, J; Zhang, J1
Agrawal, S; Ahmad, H; Arya, A; Dwivedi, AK; Khandelwal, K; Khatik, R; Mittapelly, N; Singh, A1
Adan, A; Baran, Y2
Bansal, AK; Modi, SR; Shete, G1
Chen, R; Chen, Z; Hu, C; Hu, T; Huang, C; Li, J; Li, Y; Meng, X; Qian, Z; Shen, C2
Lu, D; Ma, Z; Sun, H; Wang, X; Wu, B; Zhou, X1
Bando, M; Nakazawa, Y; Oka, M; Takehana, M1
Fan, G; Song, F; Wu, F; Ye, X1
Hisada, T; Takahashi, S; Unno, T1
de Araújo, ME; de Franco, ÉP; de Oliveira Carvalho, P; de Souza, VT; Frankland Sawaya, AC; Messias, MC; Priviero, FB1
Caldwell, RB; Kimura, S; Kobayashi, H; Matsumoto, C; Nagaoka, T; Narayanan, SP; Ono, S; Shimouchi, A; Takumi, H; Tamai, T; Yokota, H; Yoshida, A1
Dong, W; Li, J; Liao, F; Wang, J; Wu, D; Zhang, J1
Espín, JC; Giménez-Bastida, JA; González-Sarrías, A; Tomás-Barberán, FA; Vallejo, F1
Gu, L; Jia, A; Qi, Y; Rocca, JR; Sarnoski, PJ; Wang, W1
Boom, K; Borsoi, C; Celia, C; Ferrari, M; Fresta, M; Grande, R; Scott, B; Shen, H; Shen, J; Suri, K; Wolfram, J; Zhao, Y1
Ahmadi, A; Nabavi, SF; Nabavi, SM; Setzer, WN; Shadboorestan, A1
Ayyappa, KA; Krishnan, UM; Mohan, A; Sethuraman, S; Smina, TP1
Kilaru, N; Mullapudi, SS; Nuthakki, S; Pendyala, S; Pingili, R; Vemulapalli, S1
Barua, CC; Bodduluru, LN; Dahiya, V; Ellutla, M; Karnam, KC; Kasala, ER1
Chen, R; Chen, Z; Huang, C; Huang, X; Li, J; Li, L; Ma, T; Meng, X; Qian, Z; Shen, C; Zang, H1
Albuquerque, RM; Beraldo, H; de Azevedo, RA; Ferreira, AK; Gouvea, LR; Louro, SR; Sousa, AC; Tamayo, LV; Teixeira, SF1
Ding, S; Feng, X; Ma, H1
Keck, CM; Müller, RH; Romero, GB1
Cheng, Z; Deng, W; Guo, H; He, Y; Tang, Q; Wang, S; Wei, L; Zhang, X1
Li, MY; Ma, SX; Wang, SH; Xia, S; Yang, LJ; Yang, XD; Zhao, XQ; Zhou, SY1
Macedo, GA; Macedo, JA; Madeira, JV; Nakajima, VM1
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Abdou, HM; Ali, EY; Ghoneum, MH; Hamaad, FA1
Alam, W; Efferth, T; Hussain, Y; Khan, H1
Cielecka-Piontek, J; Płazińska, A; Płaziński, W; Rosiak, N; Tykarska, E; Wdowiak, K; Żarowski, M1
Ghasemnejad-Berenji, M; Khezri, MR; Moloodsouri, D1
Islam, J; Khan, HA; Shree, A; Sultana, S; Yadav, V1
Bellini, MZ; Buchaim, DV; Buchaim, RL; de Marchi, MÂ; Detregiachi, CRP; Fideles, SOM; Flato, UAP; Gardizani, TP; Ortiz, AC; Pagani, BT; Pereira, ESBM; Pilon, JPG; Ponce, JB; Reis, CHB; Trazzi, BFM; Veronez, FS1
Evans, JA; Mendonca, P; Soliman, KFA1
Chen, SY; Chen, X; Cheng, M; Huang, C; Li, J; Li, XF; Wang, A; Wu, S; Wu, YY; Xu, JJ; Zhu, S1
de Albuquerque-Júnior, RLC; de Araújo Andrade, T; de Araujo, GRS; de Souza Araujo, AA; de Souza Siqueira Quintans, J; Dos Santos, DM; Dos Santos, MRV; Dos Santos-Neto, AG; Frank, LA; Heimfarth, L; Lira, AAM; Matos, SS; Quintans-Júnior, LJ; Rabelo, TK; Serafini, MR1
Anbalagan, M; Gor, R; Kesavan, Y; Lazer, LM; Narayan, S; Pathak, S; Ramachandran, I; Ramalingam, S1
Idrees, M; Joo, MD; Khan, AM; Kong, IK; Kumar, V; Lee, KW; Uddin, Z1
Cheng, M; Huang, C; Li, J; Niu, XN; Shi, W; Wu, YY; Yang, YL; Yin, NN; Zhang, YL; Zhu, L1
Fang, H; Gong, J; Lin, Y; Ren, J; Su, D; Tang, L; Wang, Y; Xu, S; Yang, H1
Bazan-Woźniak, A; Cielecka-Piontek, J; Pietrzak, R; Walkowiak, J; Wdowiak, K1
Cheng, Y; Fan, L; Li, Y; Lu, Q; Lu, Z; Luan, X; Luo, D; Xia, Q; Zeng, N1
Kao, CH; Lu, CK; Shen, ZQ; Teng, YC; Tsai, TF; Wang, TW; Yeh, CH; Yeh, TK1
Bernroider, M; Chen, L; Feng, GW; Genser, J; Hierlmeier, G; Hu, XX; Lan, YJ; Leitner, C; Li, H; Lin, DF; Lyu, KY; Meng, L; Neubauer, F; Qu, X; Shen, T; Sun, RC; Wang, C; Weng, SF; Wolf, R; Xu, QY; Yang, SX; Yao, ZM; Zhang, LZ; Zhang, M; Zhang, NX; Zhang, X; Zhu, DX; Zhu, JJ; Zhu, S1
Eltelbany, RFA; Khalil, HMA; Rasheed, RA; Zaafar, D; Zaitone, SA1
Bakhtiyari, M; Nabi-Afjadi, M; Rostampour, P; Shapourian, H; Tavakol, C; Zalpoor, H1
Hodaei, M; Varshosaz, J1
Chakraborty, R; El-Sherbiny, M; Eladl, MA; Elsherbini, DMA; Famurewa, AC; Goutam Mukherjee, A; Madhyastha, H; Myakala, H; Ramesh Wanjari, U; Renu, K; Valsala Gopalakrishnan, A; Vellingiri, B1
Amirinejad, M; Badiee, A; Davoodi, J; Gheybi, F; Omidfar, F1
Arjsri, P; Dejkriengkraikul, P; Mapoung, S; Semmarath, W; Srisawad, K; Thippraphan, P; Umsumarng, S; Yodkeeree, S1
Endo, H; Sakusa, K; Tanaka, M; Yano, M1
Cao, Z; Chen, C; Chen, G; Lei, H; Lu, Y; Song, Y; Wu, F; Zhang, C; Zhang, L; Zhou, J1
Bae, J; Fujimura, Y; Fujino, K; Kumazoe, M; Marugame, Y; Nezu, A; Tachibana, H; Yoshimoto, T1
Aghazadeh, M; Alipour, M; Dizaj, SM; Samiei, M; Shahi, S; Sharifi, S1
Bojarová, P; Brodsky, K; Franková, J; Hanyk, J; Křen, V; Novotná, R; Škařupová, D; Ulrichová, J; Vostálová, J1
Chen, P; Chen, S; Gao, Q; Mao, S; Ren, Y; Tian, J; Wu, J; Ye, X; Yu, D1
Amanlou, M; Khorsand, B; Rostamabadi, H; Samandari-Bahraseman, MR; Zareei, S1
Cui, Z; Li, L; Liu, F; Lu, F; Qu, L; Wang, W1

Reviews

23 review(s) available for hesperidin and hesperetin

ArticleYear
Neuroprotective effects of citrus flavonoids.
    Journal of agricultural and food chemistry, 2012, Feb-01, Volume: 60, Issue:4

    Topics: Antioxidants; Blood-Brain Barrier; Citrus; Diet; Flavonoids; Fruit; Hesperidin; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Signal Transduction

2012
Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin--a mini-review.
    Life sciences, 2014, Sep-15, Volume: 113, Issue:1-2

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Citrus; Cytochrome P-450 Enzyme System; Hesperidin; Humans; Learning; Memory; Signal Transduction; Terfenadine

2014
Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Citrus; Disease Models, Animal; Hesperidin; Humans; Inflammation; NF-kappa B; Oxidative Stress; Signal Transduction

2015
Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases.
    Life sciences, 2015, Mar-01, Volume: 124

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Diseases; Citrus; Free Radical Scavengers; Hesperidin; Humans; Neoplasms

2015
Health-promoting effects of the citrus flavanone hesperidin.
    Critical reviews in food science and nutrition, 2017, Feb-11, Volume: 57, Issue:3

    Topics: Anti-Inflammatory Agents; Antioxidants; Carcinoma; Cardiovascular Diseases; Citrus; Drug Combinations; Hesperidin; Humans; Nervous System Diseases; Randomized Controlled Trials as Topic

2017
Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin.
    Life sciences, 2015, Sep-15, Volume: 137

    Topics: Animals; Anti-Infective Agents; Hesperidin; Humans; Models, Biological; Protective Agents

2015
The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer.
    Current medicinal chemistry, 2015, Volume: 22, Issue:30

    Topics: Anticarcinogenic Agents; Antineoplastic Agents; Citrus; Hesperidin; Humans; Neoplasms; Signal Transduction

2015
Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review.
    Phytotherapy research : PTR, 2016, Volume: 30, Issue:4

    Topics: Aloe; Cell Differentiation; Cell Proliferation; Centella; Coumarins; Epimedium; Flavonoids; Hesperidin; Humans; Mannans; Morinda; Osteogenesis; Periodontal Ligament; Plant Extracts; Triterpenes; Zanthoxylum

2016
Flavanones: Citrus phytochemical with health-promoting properties.
    BioFactors (Oxford, England), 2017, Jul-08, Volume: 43, Issue:4

    Topics: Animals; Antioxidants; Citrus; Flavanones; Flavonoids; Hesperidin; Humans; Oxidative Stress

2017
Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2020, Jul-15, Volume: 73

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Citrus; Hesperidin; Humans; Neoplasms

2020
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.
    Nutrients, 2020, Sep-23, Volume: 12, Issue:10

    Topics: Animals; Antioxidants; Citrus; Diabetes Mellitus; Disaccharides; Flavanones; Flavones; Flavonoids; Glycosides; Hesperidin; Humans; Inflammation; Phytochemicals; Polyphenols; Propiophenones

2020
Hesperetin's health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations.
    Critical reviews in food science and nutrition, 2022, Volume: 62, Issue:16

    Topics: Antioxidants; Biological Availability; Citrus; Flavonoids; Hesperidin

2022
    Biomaterial investigations in dentistry, 2021, Volume: 8, Issue:1

    Topics: Adult; Alcohol Drinking; Ammonia; Animals; Anti-Inflammatory Agents; Area Under Curve; B-Lymphocytes; Black or African American; Bleaching Agents; Body Mass Index; Brugada Syndrome; Carbon; China; Climate Models; Codon, Nonsense; Cohort Studies; Colitis; Colon; COVID-19; Cytokines; Dental Enamel; Dextran Sulfate; Disease Models, Animal; Disease Outbreaks; Dogs; Electrocardiography; Escherichia coli; Esophageal Neoplasms; Female; Follow-Up Studies; Forests; Georgia; Glucosides; Healthy Volunteers; Heart Ventricles; Hesperidin; HIV Infections; Humans; Humidity; Hydrogen Peroxide; Incidence; Influenza, Human; Longitudinal Studies; Magnetic Resonance Imaging, Cine; Male; Melanocortins; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Middle Aged; Muscular Dystrophy, Duchenne; Naphthol AS D Esterase; Naphthols; Neoplasms; Nitrates; Nitrites; Nitrous Oxide; Obesity; Pandemics; Patient Outcome Assessment; Patient Satisfaction; Plants; Prednisolone; Prednisone; Pregnenediones; Proportional Hazards Models; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Rats; Receptor, Melanocortin, Type 1; Retrospective Studies; Risk Factors; SARS-CoV-2; Seasons; Soil; Stroke Volume; T-Lymphocytes; Telemedicine; Temperature; Tetralogy of Fallot; Tooth Bleaching; Tooth Bleaching Agents; Trees; Urea; White People

2021
[Construction of Coamorphous Technology Aimed at Improving Membrane Permeability and Application to Emulsion].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2021, Volume: 141, Issue:11

    Topics: Biological Availability; Cell Membrane Permeability; Crystallization; Drug Design; Drug Stability; Emulsions; Flavanones; Hesperidin; Oils; Phase Transition; Solubility; Temperature; Water

2021
Repurposing Natural Dietary Flavonoids in the Modulation of Cancer Tumorigenesis: Decrypting the Molecular Targets of Naringenin, Hesperetin and Myricetin.
    Nutrition and cancer, 2022, Volume: 74, Issue:4

    Topics: Carcinogenesis; Flavanones; Flavonoids; Hesperidin; Humans; Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases

2022
Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.
    International journal of molecular sciences, 2022, Feb-23, Volume: 23, Issue:5

    Topics: Animals; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Induction; Glutathione; Glycosylation; Hesperidin; Humans; Insulin Resistance; Lactoylglutathione Lyase; Mice; Molecular Structure; Neoplasms, Experimental; Obesity; Pyruvaldehyde; Resveratrol

2022
Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 100

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Endoplasmic Reticulum Stress; Hesperidin; Rats

2022
Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health.
    Biomolecules, 2022, 04-23, Volume: 12, Issue:5

    Topics: Bone Density; Citrus; Flavanones; Flavonoids; Hesperidin; Osteoporosis

2022
Neuroprotective Effects and Therapeutic Potential of the Citrus Flavonoid Hesperetin in Neurodegenerative Diseases.
    Nutrients, 2022, May-26, Volume: 14, Issue:11

    Topics: Anti-Inflammatory Agents; Citrus; Flavonoids; Hesperidin; Humans; Neurodegenerative Diseases; Neuroprotective Agents

2022
Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review.
    Journal of agricultural and food chemistry, 2022, Jul-20, Volume: 70, Issue:28

    Topics: Antioxidants; Citrus; Diabetes Mellitus; Hesperidin

2022
Bioavailability of Hesperidin and Its Aglycone Hesperetin-Compounds Found in Citrus Fruits as a Parameter Conditioning the Pro-Health Potential (Neuroprotective and Antidiabetic Activity)-Mini-Review.
    Nutrients, 2022, Jun-26, Volume: 14, Issue:13

    Topics: Biological Availability; Citrus; Hesperidin; Hypoglycemic Agents

2022
Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways.
    Inflammopharmacology, 2022, Volume: 30, Issue:5

    Topics: COVID-19 Drug Treatment; Hesperidin; Humans; Neoplasms; SARS-CoV-2; Signal Transduction

2022
Hesperidin and hesperetin against heavy metal toxicity: Insight on the molecular mechanism of mitigation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 149

    Topics: Animals; Arsenic; Cadmium; Chromium; Hesperidin; Humans; Lead; Mercury; Metals, Heavy

2022

Trials

15 trial(s) available for hesperidin and hesperetin

ArticleYear
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.
    Clinical pharmacology and therapeutics, 2002, Volume: 71, Issue:1

    Topics: Administration, Oral; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Beverages; Biological Availability; Carrier Proteins; Citrus; Double-Blind Method; Female; Flavonoids; Food-Drug Interactions; Fruit; HeLa Cells; Histamine H1 Antagonists; Humans; Intestinal Absorption; Male; Malus; Membrane Transport Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Symporters; Terfenadine

2002
Two high-performance liquid chromatographic assays for the determination of free and total silibinin diastereomers in plasma using column switching with electrochemical detection and reversed-phase chromatography with ultraviolet detection.
    Journal of chromatography. B, Biomedical applications, 1995, Aug-18, Volume: 670, Issue:2

    Topics: Chromatography, High Pressure Liquid; Electrochemistry; Flavonoids; Hesperidin; Humans; Hydrolysis; Male; Middle Aged; Silymarin; Spectrophotometry, Ultraviolet; Stereoisomerism

1995
Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.
    European journal of clinical nutrition, 2002, Volume: 56, Issue:9

    Topics: Adult; Biomarkers; Cross-Over Studies; Feeding Behavior; Female; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Middle Aged; Quercetin; Reference Values; Time Factors; Vegetables

2002
Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects.
    The British journal of nutrition, 2010, Volume: 103, Issue:11

    Topics: Beverages; Biological Availability; Citrus sinensis; Cross-Over Studies; Disaccharides; Double-Blind Method; Female; Flavanones; Fruit; Glucosides; Glycoside Hydrolases; Hesperidin; Humans; Male; Placebos

2010
Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.
    European journal of clinical nutrition, 2010, Volume: 64, Issue:4

    Topics: Adult; Area Under Curve; Biological Availability; Diet; Flavanones; Hesperidin; Humans; Male; Quercetin; Young Adult

2010
Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites.
    Food & function, 2012, Volume: 3, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Blood Circulation; Body Temperature; Female; Hesperidin; Human Umbilical Vein Endothelial Cells; Humans; Male; Middle Aged; Vasodilation; Vasodilator Agents; Young Adult

2012
Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men.
    Clinical nutrition (Edinburgh, Scotland), 2015, Volume: 34, Issue:6

    Topics: Antioxidants; Apolipoprotein A-I; Ascorbic Acid; Biomarkers; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Citrus sinensis; Cross-Over Studies; Flavonoids; Fruit and Vegetable Juices; Hesperidin; Humans; Hypercholesterolemia; Male; Middle Aged; Oxidative Stress; Phytochemicals; Reactive Oxygen Species; Risk Factors; Single-Blind Method; Triglycerides

2015
Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation.
    Diabetes, 2016, Volume: 65, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Cell Line; Cross-Over Studies; Female; Glutathione; Glutathione Disulfide; Hep G2 Cells; Hesperidin; Humans; Lactoylglutathione Lyase; Male; Middle Aged; Models, Biological; Obesity; Overweight; Pyruvaldehyde; Resveratrol; Stilbenes; Young Adult

2016
Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study.
    Molecular nutrition & food research, 2016, Volume: 60, Issue:12

    Topics: Adult; Biological Availability; Citrus sinensis; Cross-Over Studies; Dose-Response Relationship, Drug; Flavanones; Food Analysis; Fruit; Fruit and Vegetable Juices; Hesperidin; Hippurates; Humans; Pasteurization; Tandem Mass Spectrometry; Young Adult

2016
Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes.
    The American journal of clinical nutrition, 2017, Volume: 106, Issue:3

    Topics: Athletes; Biological Availability; Chromatography, High Pressure Liquid; Citrus sinensis; Colon; Diet; Exercise; Flavanones; Fruit; Fruit and Vegetable Juices; Glucuronides; Hesperidin; Humans; Male; Mass Spectrometry; Oxygen Consumption; Physical Endurance; Plant Extracts; Polyphenols; Rest; Sports

2017
A Critical Evaluation of In Vitro Hesperidin 2S Bioavailability in a Model Combining Luminal (Microbial) Digestion and Caco-2 Cell Absorption in Comparison to a Randomized Controlled Human Trial.
    Molecular nutrition & food research, 2018, Volume: 62, Issue:8

    Topics: Antioxidants; Caco-2 Cells; Cinnamates; Citrus sinensis; Colon; Dietary Supplements; Digestion; Double-Blind Method; Female; Flavonoids; Fruit; Gastrointestinal Microbiome; Glucuronides; Hesperidin; Humans; Hydrolysis; Intestinal Absorption; Kinetics; Male; Models, Biological; Plant Extracts; Surface Properties

2018
Hesperetin protects crayfish Procambarus clarkii against white spot syndrome virus infection.
    Fish & shellfish immunology, 2019, Volume: 93

    Topics: Animal Feed; Animals; Astacoidea; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Hesperidin; Immunity, Innate; Longevity; Virus Replication; White spot syndrome virus 1

2019
The efficacy and safety of an antiaging topical serum containing hesperetin and sodium cyclic lysophosphatidic acid: A single-center clinical trial.
    Journal of cosmetic dermatology, 2021, Volume: 20, Issue:12

    Topics: Female; Hesperidin; Humans; Lysophospholipids; Skin; Skin Aging; Sodium

2021
Reversal of Insulin Resistance in Overweight and Obese Subjects by
    Nutrients, 2021, Jul-11, Volume: 13, Issue:7

    Topics: Adult; Blood Pressure; Body Mass Index; Carrier Proteins; Correlation of Data; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Female; Glucose Metabolism Disorders; Glycosylation; Hesperidin; Humans; Inflammation; Inflammation Mediators; Insulin Resistance; Leukocytes, Mononuclear; Male; Obesity; Overweight; Pyruvaldehyde; Resveratrol; Tumor Necrosis Factor-alpha

2021
Concomitant use of tea catechins affects absorption and serum triglyceride-lowering effects of monoglucosyl hesperidin.
    Food & function, 2021, Oct-04, Volume: 12, Issue:19

    Topics: Adult; Beverages; Catechin; Cross-Over Studies; Double-Blind Method; Female; Glucosides; Hesperidin; Humans; Male; Middle Aged; Single-Blind Method; Tea; Triglycerides

2021

Other Studies

471 other study(ies) available for hesperidin and hesperetin

ArticleYear
Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes.
    Journal of natural products, 1999, Volume: 62, Issue:3

    Topics: Citrus; Cyclic AMP; Flavonoids; Humans; In Vitro Techniques; Lipopolysaccharides; Monocytes; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

1999
Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.
    Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7

    Topics: Caco-2 Cells; Electrophoresis, Capillary; Flavanones; Flavones; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Molecular Structure; Molecular Weight

2008
Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.
    Bioorganic & medicinal chemistry, 2010, Jan-01, Volume: 18, Issue:1

    Topics: Flavonoids; Free Radical Scavengers; Models, Biological; Quantitative Structure-Activity Relationship; Quantum Theory; Software; Thermodynamics

2010
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Thrombin inhibitory activity of some polyphenolic compounds.
    Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2014, Volume: 23

    Topics:

2014
Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro.
    Bioorganic & medicinal chemistry, 2019, 01-15, Volume: 27, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Flavones; Histone Demethylases; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Structure-Activity Relationship

2019
Molecular characterization and regulation of the rhizosphere-expressed genes rhiABCR that can influence nodulation by Rhizobium leguminosarum biovar viciae.
    Journal of bacteriology, 1992, Volume: 174, Issue:12

    Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; DNA-Binding Proteins; Flavonoids; Gene Expression Regulation, Bacterial; Hesperidin; Molecular Sequence Data; Operon; Plasmids; Recombinant Fusion Proteins; Rhizobium leguminosarum; Sequence Alignment; Trans-Activators

1992
Stimulation of indole-3-acetic acid production in Rhizobium by flavonoids.
    FEBS letters, 1991, Apr-22, Volume: 282, Issue:1

    Topics: Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Gene Expression Regulation, Bacterial; Hesperidin; Indoleacetic Acids; Isoflavones; Kinetics; Luteolin; Rhizobium

1991
How flavonoids inhibit the generation of luminol-dependent chemiluminescence by activated human neutrophils.
    Chemico-biological interactions, 1990, Volume: 73, Issue:2-3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Flavanones; Flavonoids; Flavonols; Hesperidin; Humans; Luminescent Measurements; Luminol; Luteolin; Neutrophils; Oxygen; Peroxidase; Pyridazines; Quercetin; Superoxides; Tetradecanoylphorbol Acetate; Xanthine Oxidase

1990
In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids.
    Carcinogenesis, 1990, Volume: 11, Issue:12

    Topics: Aflatoxins; Chamomile; Chromatography, High Pressure Liquid; Dihydropyridines; Felodipine; Flavanones; Flavins; Flavonoids; Gene Expression Regulation; Hesperidin; Humans; In Vitro Techniques; Kaempferols; Microsomes, Liver; Oils, Volatile; Plants, Medicinal; Quercetin; Transcriptional Activation

1990
Molecular characterization of the nodulation gene, nodT, from two biovars of Rhizobium leguminosarum.
    Molecular microbiology, 1990, Volume: 4, Issue:2

    Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Flavonoids; Gene Expression Regulation, Bacterial; Genes, Bacterial; Hesperidin; Molecular Sequence Data; Mutation; Operon; Phenotype; Rhizobium

1990
Transcription of rhiA, a gene on a Rhizobium leguminosarum bv. viciae Sym plasmid, requires rhiR and is repressed by flavanoids that induce nod genes.
    Molecular microbiology, 1989, Volume: 3, Issue:1

    Topics: Bacterial Proteins; Chamomile; Flavonoids; Gene Expression Regulation; Genes; Genes, Bacterial; Genes, Regulator; Hesperidin; Nitrogen Fixation; Oils, Volatile; Plants, Medicinal; Plasmids; Restriction Mapping; Rhizobium; Transcription, Genetic

1989
Antiviral effect of flavonoids on human viruses.
    Journal of medical virology, 1985, Volume: 15, Issue:1

    Topics: Animals; Catechin; Cell Line; Flavanones; Flavonoids; Hesperidin; Humans; Parainfluenza Virus 3, Human; Poliovirus; Quercetin; Respiratory Syncytial Viruses; Simplexvirus; Viral Plaque Assay; Virus Physiological Phenomena; Virus Replication; Viruses

1985
[The antioxidant activity of citrus fruit peels].
    Zeitschrift fur Ernahrungswissenschaft, 1986, Volume: 25, Issue:1

    Topics: Antioxidants; Ascorbic Acid; Citrus; Flavanones; Flavonoids; Freeze Drying; Hesperidin; Vitamin E

1986
Effects of flavonoids on enzyme secretion and endocytosis in normal and mucolipidosis II fibroblasts.
    Life sciences, 1986, Aug-25, Volume: 39, Issue:8

    Topics: Acetylglucosaminidase; Biological Transport; Cells, Cultured; Endocytosis; Fibroblasts; Flavanones; Flavonoids; Hesperidin; Hexosaminidases; Humans; Mucolipidoses

1986
Flavonoids as antioxidant agents: importance of their interaction with biomembranes.
    Free radical biology & medicine, 1995, Volume: 19, Issue:4

    Topics: Animals; Antioxidants; Brain; Calorimetry, Differential Scanning; Cell Membrane; Ferrous Compounds; Flavanones; Flavonoids; Hesperidin; Lipid Peroxidation; Liposomes; Male; Malondialdehyde; Oxidation-Reduction; Quercetin; Rats; Rats, Sprague-Dawley; Rutin; Thermodynamics; Thiobarbituric Acid Reactive Substances

1995
Antilipolytic action of hesperetin in rat adipocytes.
    Planta medica, 1993, Volume: 59, Issue:6

    Topics: Adipocytes; Animals; Carbohydrate Sequence; Flavonoids; Hesperidin; In Vitro Techniques; Insulin; Lipolysis; Male; Molecular Sequence Data; Rats; Rats, Wistar

1993
Inhibition of catechol O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by quercetin. Possible role in estradiol-induced tumorigenesis.
    The Journal of biological chemistry, 1996, Jan-19, Volume: 271, Issue:3

    Topics: Animals; Catechol O-Methyltransferase Inhibitors; Cricetinae; Enzyme Inhibitors; Estradiol; Estrogens, Catechol; Flavonoids; Flavonols; Hesperidin; Kidney; Kidney Neoplasms; Kinetics; Male; Mesocricetus; Methylation; Oxidation-Reduction; Quercetin; S-Adenosylhomocysteine

1996
Increase of ocular blood flow by some phytogenic compounds.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 1996,Summer, Volume: 12, Issue:2

    Topics: Acetophenones; Administration, Topical; Animals; Anticoagulants; Antioxidants; Coumarins; Eye; Flavonoids; Hesperidin; Microspheres; Mydriatics; p-Hydroxyamphetamine; Rabbits; Regional Blood Flow; Reserpine

1996
Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices.
    Nutrition and cancer, 1996, Volume: 26, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Beverages; Breast Neoplasms; Cell Division; Citrus; Female; Flavanones; Flavonoids; Genistein; Hesperidin; Humans; Isoflavones; Mammary Neoplasms, Experimental; Quercetin; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured

1996
Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone.
    The Journal of steroid biochemistry and molecular biology, 1998, Volume: 64, Issue:3-4

    Topics: Animals; Enzyme Inhibitors; Estradiol; Estrone; Female; Flavanones; Flavonoids; Glucuronates; Glucuronosyltransferase; Hesperidin; Kinetics; Mice; Mice, Inbred Strains; Microsomes, Liver; Nitrophenols; Phenols; Polymers; Rats; Rats, Inbred Strains; Tea; Uridine Diphosphate Glucuronic Acid

1998
Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin.
    Lipids, 1999, Volume: 34, Issue:6

    Topics: Apolipoproteins B; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flavanones; Flavonoids; Hesperidin; Humans; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured

1999
The small intestine can both absorb and glucuronidate luminal flavonoids.
    FEBS letters, 1999, Sep-17, Volume: 458, Issue:2

    Topics: Animals; Caffeic Acids; Chlorogenic Acid; Coumaric Acids; Flavonoids; Glucuronates; Hesperidin; Ileum; In Vitro Techniques; Intestinal Absorption; Jejunum; Kaempferols; Male; Perfusion; Propionates; Quercetin; Rats; Rats, Sprague-Dawley; Rutin

1999
Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1.
    Toxicology, 2000, Apr-03, Volume: 144, Issue:1-3

    Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Flavonoids; Hesperidin; Humans; Kinetics; Microsomes, Liver

2000
Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.
    Mutation research, 2000, Apr-28, Volume: 459, Issue:3

    Topics: Antioxidants; Bepridil; Biphenyl Compounds; Catechin; Comet Assay; DNA; DNA Damage; Flavanones; Flavonoids; Free Radical Scavengers; Genistein; Hesperidin; Humans; Indicators and Reagents; Isoflavones; Jurkat Cells; Molsidomine; Nitric Oxide Donors; Oxidation-Reduction; Picrates; Quercetin

2000
Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice.
    The Journal of nutrition, 2001, Volume: 131, Issue:2

    Topics: Adult; Antioxidants; Area Under Curve; Beverages; Biological Availability; Biomarkers; Chromatography, High Pressure Liquid; Citrus; Diet; Estrogen Antagonists; Female; Flavanones; Flavonoids; Hesperidin; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Urinalysis

2001
Effect of six flavonoids on proliferation of hepatic stellate cells in vitro.
    Acta pharmacologica Sinica, 2000, Volume: 21, Issue:3

    Topics: Animals; Cell Division; Cells, Cultured; Culture Media, Conditioned; Female; Flavonoids; Flavonols; Hesperidin; Kupffer Cells; Mice; Mice, Inbred ICR; Platelet-Derived Growth Factor; Quercetin

2000
Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.
    Journal of lipid research, 2001, Volume: 42, Issue:5

    Topics: Anticholesteremic Agents; Apolipoproteins B; Carcinoma, Hepatocellular; Carrier Proteins; Cholesterol; Cholesterol Esters; Citrus; Enzyme-Linked Immunosorbent Assay; Flavanones; Flavonoids; Hepatocytes; Hesperidin; Humans; Receptors, LDL; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2; Triglycerides; Tumor Cells, Cultured

2001
Effects of heavy ion radiation on the brain vascular system and embryonic development.
    Advances in space research : the official journal of the Committee on Space Research (COSPAR), 1984, Volume: 4, Issue:10

    Topics: Abnormalities, Radiation-Induced; Animals; Animals, Newborn; Brain; Cerebral Hemorrhage; Cerebrovascular Circulation; Dose-Response Relationship, Radiation; Embryo, Mammalian; Female; Flavonoids; Hesperidin; Iron; Linear Energy Transfer; Mice; Neon; Pregnancy; Radiation, Ionizing; Rats; Rats, Inbred F344; Relative Biological Effectiveness; X-Rays

1984
Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.
    Plant foods for human nutrition (Dordrecht, Netherlands), 2001, Volume: 56, Issue:4

    Topics: Animals; Cholesterol; Diet; Fatty Acids; Flavonoids; Glucosephosphate Dehydrogenase; Hesperidin; Liver; Malate Dehydrogenase; Male; Microsomes, Liver; Orotic Acid; Phosphatidate Phosphatase; Rats; Rats, Sprague-Dawley; Triglycerides

2001
Effect of exogenous flavonoids on nodulation of pea (Pisum sativum L.).
    Journal of experimental botany, 2002, Volume: 53, Issue:375

    Topics: beta-Galactosidase; Flavanones; Flavonoids; Hesperidin; Hydroponics; Nitrogenase; Pisum sativum; Plant Roots; Quercetin; Rhizobium leguminosarum; Symbiosis

2002
Flavonoid intake and risk of chronic diseases.
    The American journal of clinical nutrition, 2002, Volume: 76, Issue:3

    Topics: Adult; Arthritis, Rheumatoid; Asthma; Cataract; Cerebrovascular Disorders; Chronic Disease; Diabetes Mellitus, Type 2; Diet; Female; Flavanones; Flavonoids; Hesperidin; Humans; Kaempferols; Lung Neoplasms; Male; Middle Aged; Mortality; Myocardial Ischemia; Neoplasms; Prostatic Neoplasms; Quercetin; Risk; Risk Factors; Surveys and Questionnaires

2002
Kinetic evaluation of the reactivity of flavonoids as radical scavengers.
    SAR and QSAR in environmental research, 2002, Volume: 13, Issue:6

    Topics: Catechin; Flavonoids; Free Radical Scavengers; Free Radicals; Hesperidin; Kinetics; Molecular Structure; Polymers; Propyl Gallate; Quercetin; Resveratrol; Stilbenes; Structure-Activity Relationship

2002
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats.
    Clinica chimica acta; international journal of clinical chemistry, 2003, Volume: 327, Issue:1-2

    Topics: Animals; Caffeic Acids; Cholesterol; Cholesterol, Dietary; Coumaric Acids; Hesperidin; Hydroxymethylglutaryl CoA Reductases; Lipids; Male; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase; Triglycerides

2003
Anti-Sindbis activity of flavanones hesperetin and naringenin.
    Biological & pharmaceutical bulletin, 2003, Volume: 26, Issue:1

    Topics: Animals; Antiviral Agents; Cricetinae; Flavanones; Flavonoids; Hesperidin; Sindbis Virus

2003
Interaction between flavonoids and the blood-brain barrier: in vitro studies.
    Journal of neurochemistry, 2003, Volume: 85, Issue:1

    Topics: Animals; Anthocyanins; Blood-Brain Barrier; Brain; Cell Line; Chromatography, High Pressure Liquid; Coculture Techniques; Endothelium, Vascular; Flavanones; Flavonoids; Glioma; Glucuronides; Hesperidin; Mass Spectrometry; Mice; Microcirculation; Rats

2003
[Prediction of eluotropic sequence of solutes in countercurrent chromatography].
    Se pu = Chinese journal of chromatography, 2002, Volume: 20, Issue:6

    Topics: Countercurrent Distribution; Hesperidin; Mathematics; Models, Chemical; Scopoletin; Solvents; Umbelliferones

2002
Pro-oxidative properties of flavonoids in human lymphocytes.
    Bioscience, biotechnology, and biochemistry, 2003, Volume: 67, Issue:6

    Topics: Cell Survival; Deoxyribose; DNA Damage; Flavanones; Flavonoids; Hesperidin; Humans; Hydrogen Peroxide; Lymphocytes; Membrane Proteins; Oxidants; Oxidation-Reduction; Quercetin; Superoxides

2003
Hypocholesterolemic activity of hesperetin derivatives.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Cholesterol, Dietary; Ethers; Hesperidin; Hypercholesterolemia; Mice; Structure-Activity Relationship; Time Factors

2003
Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.
    Biochemical pharmacology, 2003, Oct-01, Volume: 66, Issue:7

    Topics: Apoptosis; beta-Glucosidase; Caspase 1; Caspase 3; Caspases; Drug Interactions; Flavanones; Flavonoids; Glycoside Hydrolases; Guanine Nucleotide Dissociation Inhibitors; Hesperidin; HL-60 Cells; Humans; Multienzyme Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neutrophils; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; rho Guanine Nucleotide Dissociation Inhibitor beta; rho-Specific Guanine Nucleotide Dissociation Inhibitors

2003
Comparative study of flavonoids in experimental models of inflammation.
    Pharmacological research, 2003, Volume: 48, Issue:6

    Topics: Animals; Arthritis, Experimental; Carrageenan; Disease Models, Animal; Ear; Edema; Flavonoids; Hesperidin; Hindlimb; Inflammation; Mice; Molecular Structure; Quercetin; Random Allocation; Rats; Rats, Wistar; Rutin; Xylenes

2003
Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts.
    Photochemistry and photobiology, 2003, Volume: 78, Issue:3

    Topics: Cell Line; Chromatography, High Pressure Liquid; Fibroblasts; Flavonoids; Glucuronides; Hesperidin; Humans; Mass Spectrometry; Skin

2003
Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Mar-05, Volume: 801, Issue:2

    Topics: Chromatography, High Pressure Liquid; Citrus; Flavanones; Fruit; Hesperidin; Humans; Quality Control; Reproducibility of Results; Sensitivity and Specificity

2004
Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora.
    Journal of agricultural and food chemistry, 2004, Apr-07, Volume: 52, Issue:7

    Topics: Citrus sinensis; Flavanones; Flavonoids; Fruit; Fungicides, Industrial; Hesperidin; Phytophthora; Plant Diseases

2004
Determination of hesperetin, cinnamic acid and nicotinic acid in propolis with micellar electrokinetic capillary chromatography.
    Fitoterapia, 2004, Volume: 75, Issue:3-4

    Topics: Anti-Infective Agents; Chromatography, Micellar Electrokinetic Capillary; Cinnamates; Hesperidin; Humans; Hydrogen-Ion Concentration; Niacin; Phytotherapy; Propolis; Reproducibility of Results

2004
Antiallergic activity of hesperidin is activated by intestinal microflora.
    Pharmacology, 2004, Volume: 71, Issue:4

    Topics: Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Line; Citrus; Dinoprostone; Free Radical Scavengers; Guinea Pigs; Hesperidin; Histamine Release; Humans; Hyaluronoglucosaminidase; In Vitro Techniques; Intestinal Mucosa; Intestines; Macrophages; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Passive Cutaneous Anaphylaxis

2004
Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages.
    Journal of cellular physiology, 2005, Volume: 202, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Disaccharides; Drug Stability; Drug Synergism; Flavanones; Flavonoids; Glycosylation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hesperidin; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peritoneum; RNA Stability; RNA, Messenger; Teichoic Acids

2005
Hesperetin: a potent antioxidant against peroxynitrite.
    Free radical research, 2004, Volume: 38, Issue:7

    Topics: Animals; Antioxidants; Cell Line; Free Radical Scavengers; Hesperidin; Nitric Oxide; Peroxynitrous Acid; Rats; Reactive Oxygen Species; Serum Albumin, Bovine; Superoxides

2004
Reactions of the flavonoid hesperetin with chlorine: a spectroscopic study of the reaction pathways.
    Environmental science & technology, 2004, Sep-01, Volume: 38, Issue:17

    Topics: Chlorine; Chromatography, High Pressure Liquid; Hesperidin; Hydrogen-Ion Concentration; Mass Spectrometry; Models, Chemical; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Water Purification

2004
The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.
    Molecular nutrition & food research, 2004, Volume: 48, Issue:4

    Topics: Animals; Cecum; Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Hesperidin; Models, Animal; Quercetin; Spectrometry, Mass, Electrospray Ionization; Swine

2004
Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.
    Atherosclerosis, 2005, Volume: 178, Issue:1

    Topics: Animals; Cell Membrane; Cells, Cultured; Citrus; Flavanones; Flavones; Fruit; Hesperidin; Lipoproteins, LDL; Lipoproteins, VLDL; Macrophages; Mice; Receptors, Immunologic; Receptors, Scavenger; Scavenger Receptors, Class A

2005
Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:6

    Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Dose-Response Relationship, Drug; Free Radical Scavengers; Hesperidin; Male; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Superoxides; Vasodilation

2004
Stereospecific high-performance liquid chromatographic analysis of hesperetin in biological matrices.
    Journal of pharmaceutical and biomedical analysis, 2005, Mar-09, Volume: 37, Issue:3

    Topics: Administration, Oral; Adult; Animals; Chromatography, High Pressure Liquid; Hesperidin; Humans; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism

2005
Interaction between hesperetin and human serum albumin revealed by spectroscopic methods.
    Biochimica et biophysica acta, 2005, Jun-20, Volume: 1724, Issue:1-2

    Topics: Hesperidin; Humans; Hydrogen-Ion Concentration; Protein Binding; Protein Conformation; Serum Albumin; Spectrum Analysis

2005
Determination of active components in rosemary by capillary electrophoresis with electrochemical detection.
    Journal of pharmaceutical and biomedical analysis, 2005, Sep-15, Volume: 39, Issue:3-4

    Topics: Antioxidants; Apigenin; Buffers; Caffeic Acids; Chromatography, High Pressure Liquid; Cinnamates; Coumaric Acids; Depsides; Electrochemistry; Electrodes; Electrophoresis, Capillary; Flavonoids; Hesperidin; Hydrogen-Ion Concentration; Ions; Luteolin; Models, Chemical; Plant Extracts; Regression Analysis; Rosmarinic Acid; Rosmarinus; Temperature; Time Factors

2005
Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids.
    The British journal of nutrition, 2005, Volume: 93, Issue:5

    Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Catechin; Cells, Cultured; Copper; Endothelial Cells; Flavonoids; Gene Expression; Genes, bcl-2; Hesperidin; Humans; Lipoproteins, LDL; Proto-Oncogene Proteins c-bcl-2; Quercetin; Rutin; Thiobarbituric Acid Reactive Substances; Umbilical Veins

2005
The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites.
    European journal of nutrition, 2006, Volume: 45, Issue:2

    Topics: Animals; Bile Ducts; Biological Availability; Chromatography, High Pressure Liquid; Coumaric Acids; Dose-Response Relationship, Drug; Flavonoids; Genistein; Hesperidin; Intestinal Absorption; Intestine, Small; Liver; Male; Molecular Structure; Perfusion; Phenols; Polyphenols; Rats; Rats, Wistar

2006
The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-beta-cyclodextrin.
    Journal of pharmaceutical and biomedical analysis, 2005, Sep-15, Volume: 39, Issue:3-4

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Chemistry, Pharmaceutical; Comet Assay; Drug Industry; Flavanones; Glucosides; Hesperidin; Hydroxyl Radical; Iron; Microscopy, Fluorescence; Models, Chemical; Oxygen; Protein Binding; Solubility; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Ultraviolet Rays; Water

2005
Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.
    Antiviral research, 2005, Volume: 68, Issue:1

    Topics: Animals; Anthraquinones; Chlorocebus aethiops; Coloring Agents; Coronavirus 3C Proteases; Cysteine Endopeptidases; Emodin; Endopeptidases; Enzyme Inhibitors; Glucosinolates; Hesperidin; Indigo Carmine; Indoles; Isatis; Phenols; Plant Extracts; Plant Roots; Vero Cells; Viral Proteins

2005
Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids.
    Nutrition (Burbank, Los Angeles County, Calif.), 2006, Volume: 22, Issue:5

    Topics: Animals; Fatty Acids; Flavanones; Gene Expression Regulation, Enzymologic; Hesperidin; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred ICR; Oxidation-Reduction; Peroxisomes; Random Allocation; RNA, Messenger; Up-Regulation

2006
Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:3

    Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Hesperidin; Hippocampus; In Vitro Techniques; Male; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tetraethylammonium

2006
Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans.
    Journal of nutritional science and vitaminology, 2006, Volume: 52, Issue:1

    Topics: Adult; Chromatography, High Pressure Liquid; Citrus; Flavanones; Flavones; Flavonoids; Fruit; Glucuronidase; Glycosides; Hesperidin; Humans; Kinetics; Male; Sulfatases

2006
Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells.
    Nutrition (Burbank, Los Angeles County, Calif.), 2006, Volume: 22, Issue:9

    Topics: Animals; Antioxidants; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Embryonic Stem Cells; Endothelial Cells; Free Radical Scavengers; Glutathione; Hesperidin; Immunohistochemistry; Mice; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species

2006
Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.
    Biochemical and biophysical research communications, 2006, Sep-08, Volume: 347, Issue:4

    Topics: Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Hesperidin; Humans; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Signal Transduction; Tyrosine

2006
Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2007, Volume: 17, Issue:9

    Topics: Amino Acids, Aromatic; Animals; Cardiovascular Diseases; Citrus sinensis; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Hesperidin; Mutation; Oocytes; Patch-Clamp Techniques; Potassium Channel Blockers; Xenopus

2007
Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin.
    Aging cell, 2006, Volume: 5, Issue:5

    Topics: Aging; Animals; Cell Culture Techniques; Cell Line; Endothelial Cells; Epithelial Cells; Gene Expression Regulation; Genes, Reporter; Hesperidin; Humans; Kidney; Luciferases; Macrophages; Male; Mice; Molecular Structure; NF-kappa B; Rats; Rats, Inbred F344; Reactive Oxygen Species; Transcription, Genetic

2006
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin.
    Archives of pharmacal research, 2006, Volume: 29, Issue:8

    Topics: Animals; Antioxidants; Biphenyl Compounds; Cell Survival; Cell-Free System; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Hesperidin; Lipid Peroxidation; Neurons; Neuroprotective Agents; Oxidative Stress; Picrates; Rats

2006
Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.
    European journal of clinical nutrition, 2007, Volume: 61, Issue:4

    Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Citrus; Dietary Supplements; Female; Flavanones; Hesperidin; Humans; Intestinal Absorption; Male

2007
Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity.
    Atherosclerosis, 2007, Volume: 194, Issue:1

    Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cyclooxygenase 1; Flavonoids; Hesperidin; Phospholipase C gamma; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin D2; Rabbits; Serotonin; Thromboxane-A Synthase

2007
Enantioseparation of some chiral flavanones using microbial cyclic beta-(1-->3),(1-->6)-glucans as novel chiral additives in capillary electrophoresis.
    Carbohydrate research, 2007, Apr-09, Volume: 342, Issue:5

    Topics: beta-Glucans; Bradyrhizobium; Carbohydrate Sequence; Electrophoresis, Capillary; Flavanones; Flavones; Flavonoids; Hesperidin; Hydrogen-Ion Concentration; Molecular Sequence Data; Stereoisomerism

2007
Flavanone plasma pharmacokinetics from blood orange juice in human subjects.
    The British journal of nutrition, 2007, Volume: 98, Issue:1

    Topics: Adult; Antioxidants; Beverages; Chromatography, High Pressure Liquid; Citrus sinensis; Cross-Over Studies; Disaccharides; Estrogen Antagonists; Female; Flavanones; Hesperidin; Humans; Intestinal Absorption; Tandem Mass Spectrometry

2007
Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS.
    Journal of separation science, 2007, Volume: 30, Issue:6

    Topics: Calibration; Chromatography, High Pressure Liquid; Citrus; Drugs, Chinese Herbal; Flavanones; Fruit; Hesperidin; Mass Spectrometry; Molecular Structure; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2007
Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation.
    Cell biology and toxicology, 2008, Volume: 24, Issue:3

    Topics: 3T3 Cells; Animals; Carbohydrates; Cell Differentiation; Hesperidin; Lipid Peroxidation; Mice; Osteoblasts

2008
Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21.
    Nutrition and cancer, 2007, Volume: 59, Issue:1

    Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Female; G1 Phase; Hesperidin; Humans; Time Factors

2007
Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle.
    Journal of cellular biochemistry, 2008, May-01, Volume: 104, Issue:1

    Topics: Animals; Aorta; Becaplermin; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Citrus; Flavanones; Hesperidin; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats

2008
Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers.
    Biochimica et biophysica acta, 2008, Volume: 1778, Issue:1

    Topics: Biological Transport; Caco-2 Cells; Chromatography, High Pressure Liquid; Epithelial Cells; Hesperidin; Humans; Models, Biological; Protons

2008
Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.
    Journal of applied microbiology, 2007, Volume: 103, Issue:6

    Topics: Anti-Bacterial Agents; Bacteriological Techniques; Citrus; Colony Count, Microbial; Flavanones; Flavonoids; Gram-Negative Bacteria; Gram-Positive Bacteria; Hesperidin; Microbial Sensitivity Tests; Oils, Volatile; Plant Extracts; Polygalacturonase; Saccharomyces cerevisiae

2007
Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices.
    Biopharmaceutics & drug disposition, 2008, Volume: 29, Issue:2

    Topics: Animals; Area Under Curve; Beverages; Flavanones; Fruit; Half-Life; Hesperidin; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism

2008
Glycosylation of hesperetin by plant cell cultures.
    Phytochemistry, 2008, Volume: 69, Issue:5

    Topics: Biotransformation; Cell Culture Techniques; Eucalyptus; Glycosylation; Hesperidin; Ipomoea batatas; Magnetic Resonance Spectroscopy; Molecular Structure; Reference Standards; Time Factors

2008
Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells.
    Journal of agricultural and food chemistry, 2008, Feb-13, Volume: 56, Issue:3

    Topics: Cells, Cultured; Citrus; Endothelial Cells; Flavanones; Gene Expression; Hesperidin; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Phytoestrogens; RNA, Messenger; Umbilical Veins

2008
Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.
    The Journal of biological chemistry, 2008, Apr-04, Volume: 283, Issue:14

    Topics: Aldehyde Reductase; Animals; Bradykinin; Dithiothreitol; Enzyme Activation; Enzyme Inhibitors; Ferric Compounds; Glucose; Hesperidin; Hypoglycemic Agents; Imidazolidines; Insulin; Lipid Peroxidation; Male; Metalloporphyrins; Myocardial Reperfusion Injury; Myocardium; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sorbitol; Vasodilator Agents

2008
Effect of adding extracted hesperetin, naringenin and pectin on egg cholesterol, serum traits and antioxidant activity in laying hens.
    Archives of animal nutrition, 2008, Volume: 62, Issue:1

    Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Chickens; Cholesterol; Egg Yolk; Eggs; Female; Flavanones; Free Radical Scavengers; Hesperidin; Lipid Metabolism; Pectins; Random Allocation; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triglycerides

2008
Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry.
    Biomedical chromatography : BMC, 2008, Volume: 22, Issue:7

    Topics: Administration, Oral; Animals; Chromatography, Liquid; Drugs, Chinese Herbal; Flavanones; Hesperidin; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tandem Mass Spectrometry

2008
Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.
    Journal of nutritional science and vitaminology, 2008, Volume: 54, Issue:1

    Topics: Acetylcholine; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Glucosides; Hesperidin; Hypertension; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Organ Culture Techniques; Rats; Rats, Inbred SHR; Rats, Wistar; Time; Vasodilation; Vasodilator Agents

2008
Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice.
    Life sciences, 2008, May-23, Volume: 82, Issue:21-22

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Biotransformation; Catalase; Electrophoresis, Polyacrylamide Gel; Glutathione; Glutathione Reductase; Hesperidin; Immunoblotting; Inactivation, Metabolic; Liver; Male; Mice; Mice, Inbred ICR; Oxidants; Oxidative Stress; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2008
Inhibition of oral carcinogenesis by citrus flavonoids.
    Nutrition and cancer, 2008, Volume: 60, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Citrus; Cricetinae; Flavanones; Flavones; Flavonoids; Hesperidin; Mouth Neoplasms; Random Allocation

2008
Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.
    Neuroscience letters, 2008, Jun-13, Volume: 438, Issue:1

    Topics: Animals; Antioxidants; Brain; Cell Death; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Hesperidin; Humans; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphorylation; Transcriptional Activation; Tumor Cells, Cultured

2008
Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:9

    Topics: ATP-Binding Cassette Transporters; Base Sequence; Caco-2 Cells; Chromatography, High Pressure Liquid; Citrus; DNA Primers; Hesperidin; Humans; Molecular Structure; Multidrug Resistance-Associated Protein 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrophotometry, Ultraviolet

2008
The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells.
    The Journal of nutrition, 2008, Volume: 138, Issue:7

    Topics: Animals; Anticholesteremic Agents; Cell Line; Citrus; Dose-Response Relationship, Drug; Flavones; Flavonoids; Genes, Reporter; Hepatocytes; Hesperidin; Humans; Luciferases; Models, Animal; Promoter Regions, Genetic; Receptors, LDL; Regulatory Elements, Transcriptional; RNA, Messenger; Transcription, Genetic; Transfection

2008
Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.
    Investigational new drugs, 2009, Volume: 27, Issue:3

    Topics: 1,2-Dimethylhydrazine; Animals; Catalase; Colonic Neoplasms; Colonic Polyps; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hesperidin; Lipid Peroxidation; Male; Microvilli; Rats; Rats, Wistar; Superoxide Dismutase; Survival Analysis; Thiobarbituric Acid Reactive Substances

2009
Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:10

    Topics: 3T3-L1 Cells; Adiponectin; Animals; Base Sequence; Citrus; DNA Primers; Dose-Response Relationship, Drug; Flavanones; Hesperidin; Mice; PPAR alpha; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Up-Regulation

2008
Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:10

    Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Citrus; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Feces; Flavanones; Hesperidin; Injections, Subcutaneous; Intestinal Mucosa; Male; Phytotherapy; Precancerous Conditions; Rats; Rats, Wistar

2008
Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:2

    Topics: Diosmin; Drug Stability; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Hesperidin; Humans; Linear Models; Male; Oxidation-Reduction; Reference Standards; Reproducibility of Results; Sensitivity and Specificity

2009
Enantiomeric separation of some flavanones using shinorhizobial linear octasaccharides in CE.
    Electrophoresis, 2008, Volume: 29, Issue:20

    Topics: Animals; Electrophoresis, Capillary; Flavanones; Flavones; Flavonoids; Hesperidin; Isomerism; Oligosaccharides; Polysaccharides, Bacterial; Sinorhizobium meliloti; Temperature

2008
Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes.
    Journal of agricultural and food chemistry, 2008, Nov-26, Volume: 56, Issue:22

    Topics: Adipocytes; Adipogenesis; Apoptosis; Cell Differentiation; Cell Division; Cell Line; Flavanones; Hesperidin; Humans

2008
Antagonistic interactions between the flavonoids hesperetin and naringenin and beta-lactam antibiotics against Staphylococcus aureus.
    British journal of biomedical science, 2008, Volume: 65, Issue:3

    Topics: Cefoxitin; Drug Interactions; Flavanones; Flavonoids; Hesperidin; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Monobactams; Penicillins; Species Specificity

2008
Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids.
    Molecular and cellular biochemistry, 2009, Volume: 321, Issue:1-2

    Topics: Animals; Apoptosis; Biomarkers; Biphenyl Compounds; Caspase 3; Cell Line, Tumor; Cell Proliferation; Flavonoids; Free Radicals; Hesperidin; Humans; Picrates; Polyamines; Rutin

2009
Neuroprotective effects of chronic hesperetin administration in mice.
    Archives of pharmacal research, 2008, Volume: 31, Issue:11

    Topics: Animals; Antioxidants; Blotting, Western; Brain Chemistry; Catalase; Female; Glutathione; Hesperidin; Mice; Mice, Inbred ICR; Neuroprotective Agents; Oxidative Stress; Protein Carbonylation; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2008
Production and characterization of Hesperetin nanosuspensions for dermal delivery.
    International journal of pharmaceutics, 2009, Apr-17, Volume: 371, Issue:1-2

    Topics: Administration, Cutaneous; Antioxidants; Drug Carriers; Drug Stability; Hesperidin; Molecular Structure; Nanoparticles; Particle Size; Scattering, Radiation; Solubility

2009
Sulfation of dietary flavonoids by human sulfotransferases.
    Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:4

    Topics: Arylsulfotransferase; Catechin; Cytosol; Flavanones; Hesperidin; Humans; Kinetics; Molecular Structure; Sulfotransferases

2009
[Effects of Hesperetin on cell activation and proliferation of murine T lymphocytes in vitro].
    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2009, Volume: 25, Issue:4

    Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Cell Proliferation; Cell Survival; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Flow Cytometry; Hesperidin; Lectins, C-Type; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mitotic Index; T-Lymphocytes

2009
Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway.
    The Journal of nutritional biochemistry, 2010, Volume: 21, Issue:5

    Topics: Alkaline Phosphatase; Animals; Bone Morphogenetic Proteins; Carrier Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Dose-Response Relationship, Drug; Gene Expression Regulation; Hesperidin; Minerals; Osteoblasts; Osteocalcin; Osteopontin; Phosphorylation; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Smad Proteins; Time Factors; Transcription Factors

2010
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.
    Archives of biochemistry and biophysics, 2009, Apr-01, Volume: 484, Issue:1

    Topics: Animals; Cells, Cultured; Coculture Techniques; Flavanones; Hesperidin; Inflammation; Interferon-gamma; Lipopolysaccharides; Mice; Neuroglia; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; STAT1 Transcription Factor

2009
Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis.
    Chemico-biological interactions, 2009, Jul-15, Volume: 180, Issue:2

    Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Citrus; Colon; Colonic Neoplasms; Hesperidin; Male; Rats

2009
Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.
    Journal of natural products, 2009, Volume: 72, Issue:7

    Topics: Citrus; Flavanones; Flavonoids; Fruit; Glycosides; Hesperidin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular

2009
Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Animals; Antioxidants; Cattle; DNA; Hesperidin; Hydrazones; Lanthanoid Series Elements; Magnetics; Molecular Structure; Spectrometry, Fluorescence; Viscosity

2009
Exploring the effect of Hesperetin-HSPC complex--a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics.
    AAPS PharmSciTech, 2009, Volume: 10, Issue:3

    Topics: Animals; Antioxidants; Calibration; Carbon Tetrachloride Poisoning; Chemistry, Pharmaceutical; Drug Delivery Systems; Glycine max; Hesperidin; Liver Function Tests; Male; Phosphatidylcholines; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Solubility; Suspensions

2009
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:10

    Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; Colonic Neoplasms; Disease Models, Animal; Hesperidin; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Superoxide Dismutase

2009
Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions.
    Drug development and industrial pharmacy, 2010, Volume: 36, Issue:3

    Topics: Capsules; Chemistry, Pharmaceutical; Diffusion; Drug Compounding; Drug Delivery Systems; Drug Stability; Excipients; Flavanones; Hesperidin; Hot Temperature; Kinetics; Models, Chemical; Nanotechnology; Pharmaceutic Aids; Povidone; Solubility; Suspensions; Tablets; Time Factors; Water

2010
Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography.
    Journal of pharmaceutical and biomedical analysis, 2010, Jan-05, Volume: 51, Issue:1

    Topics: Chromatography, Liquid; Citrus; Coumarins; Hesperidin; Humans; Male; Stereoisomerism

2010
Structural activity relationship of flavonoids with estrogen-related receptor gamma.
    FEBS letters, 2010, Jan-04, Volume: 584, Issue:1

    Topics: Apigenin; Flavanones; Flavonoids; Genistein; Heat-Shock Proteins; HeLa Cells; Hesperidin; Humans; Isoflavones; Luteolin; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Estrogen; Structure-Activity Relationship; Transcription Factors; Transcriptional Activation

2010
Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation.
    Journal of agricultural and food chemistry, 2010, Jan-13, Volume: 58, Issue:1

    Topics: Animals; Cell Differentiation; Cells, Cultured; Gene Expression; Glucuronides; Hesperidin; Osteoblasts; Rats; Rats, Wistar

2010
Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:4

    Topics: Animals; Biotransformation; Cell Line; Chromatography, High Pressure Liquid; Colon; Cytosol; DNA, Complementary; Glucosides; Glucuronosyltransferase; Hesperidin; Humans; In Vitro Techniques; Insecta; Intestine, Small; Kinetics; Liver; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sulfates; Sulfotransferases; Transfection

2010
In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system.
    International journal of pharmaceutics, 2010, Mar-30, Volume: 388, Issue:1-2

    Topics: 4-Aminobenzoic Acid; Administration, Cutaneous; Animals; Antioxidants; Drug Delivery Systems; Emulsions; Excipients; Guinea Pigs; Hesperidin; Hyperpigmentation; In Vitro Techniques; Male; Myristates; para-Aminobenzoates; Permeability; Rats; Rats, Sprague-Dawley; Skin Absorption; Surface-Active Agents; Ultraviolet Rays

2010
The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers.
    Molecular nutrition & food research, 2010, Volume: 54, Issue:6

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Flavonoids; Glucuronides; Hesperidin; Humans; Neoplasm Proteins

2010
Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Administration, Oral; Adult; Animals; Area Under Curve; Asian People; Chromatography, High Pressure Liquid; Citrus; Citrus sinensis; Cricetinae; Cricetulus; Flavanones; Hesperidin; Humans; Male; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome Protein

2010
Preserving hesperetin nanosuspensions for dermal application.
    Die Pharmazie, 2010, Volume: 65, Issue:2

    Topics: Administration, Topical; Drug Stability; Drug Storage; Electrochemistry; Hesperidin; Lasers; Light; Nanoparticles; Particle Size; Preservatives, Pharmaceutical; Scattering, Radiation; Skin Absorption; Suspensions; Temperature

2010
The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.
    Biochemical and biophysical research communications, 2010, Apr-09, Volume: 394, Issue:3

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Citrus; Fatty Acids, Nonesterified; Flavanones; Flavonoids; Hesperidin; Insulin Resistance; Lipolysis; Mice; Tumor Necrosis Factor-alpha

2010
Extracellular monoenzyme deglycosylation system of 7-O-linked flavonoid beta-rutinosides and its disaccharide transglycosylation activity from Stilbella fimetaria.
    Archives of microbiology, 2010, Volume: 192, Issue:5

    Topics: Disaccharides; DNA, Fungal; DNA, Ribosomal; Enzyme Stability; Fungal Proteins; Genes, rRNA; Glucosidases; Hesperidin; Hypocreales; Isoelectric Point; Molecular Sequence Data; Molecular Weight; RNA, Fungal; RNA, Ribosomal, 18S; Sequence Analysis, DNA; Substrate Specificity; Temperature

2010
Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.
    Journal of agricultural and food chemistry, 2010, May-26, Volume: 58, Issue:10

    Topics: Adult; Beverages; Biological Availability; Chromatography, High Pressure Liquid; Citrus sinensis; Cross-Over Studies; Female; Flavanones; Fruit; Hesperidin; Humans; Intestinal Absorption; Male; Solubility

2010
Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro.
    Journal of agricultural and food chemistry, 2010, May-26, Volume: 58, Issue:10

    Topics: Animals; Biological Transport; Caco-2 Cells; Cell Line, Tumor; Citrus sinensis; Cytosol; Fruit; Gene Expression; Glucuronides; Hesperidin; Humans; Intestine, Small; Liver Neoplasms, Experimental; Mice; Microsomes, Liver; Response Elements; Stereoisomerism; Structure-Activity Relationship; Sulfonic Acids; Transfection

2010
Hesperidin and hesperetin membrane interaction: understanding the role of 7-O-glycoside moiety in flavonoids.
    Archives of biochemistry and biophysics, 2010, Volume: 499, Issue:1-2

    Topics: Biological Availability; Calorimetry, Differential Scanning; Citrus; Dimyristoylphosphatidylcholine; Glycosides; Hesperidin; Humans; Liposomes; Membrane Potentials; Membranes, Artificial; Microscopy, Atomic Force; Models, Molecular; Powder Diffraction; Spectrometry, Fluorescence; X-Ray Diffraction

2010
The effect of component of cream for topical delivery of hesperetin.
    Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:5

    Topics: Administration, Topical; Animals; Dosage Forms; Drug Delivery Systems; Guinea Pigs; Hesperidin; Male; Pigmentation; Rats; Rats, Sprague-Dawley; Skin; Solubility

2010
Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.
    Natural product communications, 2010, Volume: 5, Issue:5

    Topics: Animals; Anthraquinones; Area Under Curve; Biphenyl Compounds; Chromatography, Liquid; Drugs, Chinese Herbal; Emodin; Female; Flavanones; Hesperidin; Lignans; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2010
Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells.
    Cellular immunology, 2010, Volume: 264, Issue:1

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cell Line; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fruit; Hesperidin; Humans; Inflammation Mediators; Interleukin-1; Interleukin-6; MAP Kinase Kinase 4; Matrix Metalloproteinase 3; Signal Transduction; Synovial Membrane

2010
Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters.
    Journal of medicinal food, 2010, Volume: 13, Issue:4

    Topics: Animals; Anticholesteremic Agents; Antioxidants; Caffeic Acids; Cholesterol; Cholesterol, HDL; Coumaric Acids; Cricetinae; Disease Models, Animal; Hesperidin; Humans; Hypercholesterolemia; Male; Mesocricetus

2010
7,3'-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation.
    Phytotherapy research : PTR, 2010, Volume: 24, Issue:12

    Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Experimental; bcl-2-Associated X Protein; Caspase 3; Cells, Cultured; Fibroblasts; Hesperidin; Male; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Synovial Membrane

2010
Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.
    Acta tropica, 2010, Volume: 116, Issue:2

    Topics: Animals; Brugia malayi; Coloring Agents; Disease Models, Animal; Elephantiasis, Filarial; Female; Filaricides; Flavanones; Flavonoids; Gerbillinae; Hesperidin; Humans; Male; Murinae; Rutin; Survival Analysis; Tetrazolium Salts; Thiazoles

2010
Protective effects of silybin and analogues against X-ray radiation-induced damage.
    Acta biochimica et biophysica Sinica, 2010, Volume: 42, Issue:7

    Topics: Antioxidants; DNA; DNA Breaks, Single-Stranded; DNA Damage; Dose-Response Relationship, Radiation; Electrophoresis, Agar Gel; Flavanones; Hesperidin; Models, Chemical; Molecular Structure; Plasmids; Silybin; Silymarin

2010
Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design.
    Journal of separation science, 2010, Volume: 33, Issue:20

    Topics: Chromatography, Liquid; Flavonoids; Hesperidin; Honey; Micelles; Quercetin

2010
Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.
    Drug metabolism and pharmacokinetics, 2010, Volume: 25, Issue:5

    Topics: Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Biocatalysis; Cytochrome P-450 CYP2C9; Diclofenac; Female; Flavonoids; Flurbiprofen; Hesperidin; Humans; Hydroxylation; Male; Microsomes, Liver; Models, Molecular; NADP; Pharmaceutical Preparations; Recombinant Proteins; Thermodynamics

2010
Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:21-22

    Topics: Animals; Anti-Bacterial Agents; beta-Glucosidase; Enterobacteriaceae; Feces; Germ-Free Life; Hesperidin; Intestines; Male; Rats; Rats, Sprague-Dawley

2010
Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2012, Volume: 64, Issue:5

    Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar

2012
Evaluation of binding and thermodynamic characteristics of interactions between a citrus flavonoid hesperitin with protein and effects of metal ions on binding.
    Molecular biology reports, 2011, Volume: 38, Issue:8

    Topics: Absorption; Animals; Binding Sites; Cattle; Circular Dichroism; Energy Transfer; Flavonoids; Fluorescence Polarization; Hesperidin; Ions; Kinetics; Metals; Protein Binding; Protein Structure, Secondary; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermodynamics

2011
Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animals.
    Oncology reports, 2011, Volume: 25, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Hesperidin; Mammary Neoplasms, Animal; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Up-Regulation

2011
Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFκB, p38 and caspase-3.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011, Volume: 49, Issue:4

    Topics: Animals; Caspase 3; Doxorubicin; Hesperidin; Immunohistochemistry; Lipid Peroxidation; Male; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Testis

2011
Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.
    Lipids in health and disease, 2011, Feb-23, Volume: 10

    Topics: Animals; Citrus; Enzyme Repression; Flavones; Gene Expression Regulation, Enzymologic; Hepatocytes; Hesperidin; Lipids; Liver; Male; Obesity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stearoyl-CoA Desaturase

2011
Hesperetin, a potential therapy for carcinoid cancer.
    American journal of surgery, 2011, Volume: 201, Issue:3

    Topics: Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Carcinoid Tumor; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gene Expression Regulation, Neoplastic; Hesperidin; Humans; Polymerase Chain Reaction; Receptor, Notch1; Signal Transduction; Stomach Neoplasms; Transcriptional Activation; Up-Regulation

2011
Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells.
    Journal of agricultural and food chemistry, 2011, May-25, Volume: 59, Issue:10

    Topics: Animals; Hesperidin; Hydrogen Peroxide; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Estrogen; Signal Transduction

2011
Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat.
    Cardiovascular toxicology, 2011, Volume: 11, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Caspase 3; Comet Assay; Cytoprotection; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Glutathione; Heart Diseases; Hesperidin; In Situ Nick-End Labeling; Male; Malondialdehyde; Myocytes, Cardiac; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Time Factors

2011
Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogenicity Tests; Cell Transformation, Neoplastic; Epstein-Barr Virus Infections; Flavanones; Genistein; Herpesvirus 4, Human; Hesperidin; Isoflavones; Mice; Oleanolic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes

2011
Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Hesperidin; Humans; Male; Mice; Pain Measurement; Potassium Channel Blockers; Protein Binding; Rats; Receptors, Opioid, mu; Xenopus laevis

2011
Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats.
    Ecotoxicology and environmental safety, 2011, Volume: 74, Issue:7

    Topics: Animals; Antioxidants; Cadmium; Cadmium Chloride; Citrus; Hesperidin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Testicular Diseases; Testis

2011
Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin.
    Cell biology and toxicology, 2011, Volume: 27, Issue:5

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Benzo(a)pyrene; beta-Cyclodextrins; Cell Death; Cytochrome P-450 CYP1A1; Flavonoids; Hesperidin; Humans; In Vitro Techniques; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Signal Transduction; Skin

2011
Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7.
    Molecular and cellular endocrinology, 2011, Sep-15, Volume: 344, Issue:1-2

    Topics: Apigenin; Aromatase; Aromatase Inhibitors; Breast Neoplasms; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Enzyme Assays; Female; Flavanones; Genes, Reporter; Hesperidin; Humans; Luciferases, Firefly; Luteolin; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Transcription Factor AP-1; Transcription, Genetic

2011
Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin.
    Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:6

    Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2C8; Flavonoids; Hesperidin; Humans; Inactivation, Metabolic; Microsomes, Liver; Molecular Dynamics Simulation; Paclitaxel

2011
Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey.
    Molecules (Basel, Switzerland), 2011, Jul-27, Volume: 16, Issue:8

    Topics: Antioxidants; Biphenyl Compounds; Caffeic Acids; Chlorogenic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Ellagic Acid; Food Irradiation; Gamma Rays; Gastrointestinal Diseases; Hesperidin; Honey; Humans; Malaysia; Oxidation-Reduction; Picrates; Propionates; Quercetin; Spectrophotometry

2011
Tissue distribution of hesperetin in rats after a dietary intake.
    Bioscience, biotechnology, and biochemistry, 2011, Volume: 75, Issue:8

    Topics: Animals; Aorta; Biological Availability; Capillary Permeability; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrus; Diet; Hesperidin; Liver; Male; Rats; Rats, Wistar; Tissue Distribution

2011
Microbial metabolism. Part 13. Metabolites of hesperetin.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    Topics: Antineoplastic Agents; Antioxidants; Drug Screening Assays, Antitumor; Fermentation; Flavanones; Hesperidin; Molecular Structure; Mucor

2011
UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices.
    Journal of pharmaceutical and biomedical analysis, 2012, Jan-05, Volume: 57

    Topics: Chromatography, Liquid; Hesperidin; Humans; Reference Standards; Stereoisomerism; Tandem Mass Spectrometry

2012
Analysis of flavonoids by capillary zone electrophoresis with electrokinetic supercharging.
    The Analyst, 2011, Nov-07, Volume: 136, Issue:21

    Topics: Clematis; Electrophoresis, Capillary; Flavanones; Flavonoids; Hesperidin; Sensitivity and Specificity; Taurine

2011
Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study.
    European review for medical and pharmacological sciences, 2011, Volume: 15, Issue:9

    Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Benzothiazoles; Biomarkers; Biphenyl Compounds; Cadmium Chloride; Dose-Response Relationship, Drug; Environmental Pollutants; Glutathione; Hesperidin; Hydroxyl Radical; Injections, Subcutaneous; Lipid Peroxidation; Lipid Peroxides; Male; Oxidative Stress; Picrates; Rats; Rats, Wistar; Sulfonic Acids; Thiobarbituric Acid Reactive Substances; Vitamin E

2011
Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2012, Jan-25, Volume: 58

    Topics: Animals; Chromatography, Liquid; Flavanones; Fruit; Glucosides; Hesperidin; Male; Rats; Rats, Wistar; Reference Standards; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2012
Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells.
    Biopharmaceutics & drug disposition, 2011, Volume: 32, Issue:9

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Baculoviridae; Cell Line; Cell Membrane; Glucuronides; Hesperidin; Humans; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Spodoptera; Transport Vesicles

2011
Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study.
    International journal of biological macromolecules, 2012, Jan-01, Volume: 50, Issue:1

    Topics: Algorithms; Anilino Naphthalenesulfonates; Binding Sites; Catalytic Domain; Computer Simulation; Flavones; Flavonoids; Hesperidin; Kinetics; Levodopa; Models, Chemical; Models, Molecular; Monophenol Monooxygenase; Spectrometry, Fluorescence; Spectrophotometry

2012
Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach.
    Journal of agricultural and food chemistry, 2012, Jan-11, Volume: 60, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Citrus; Hesperidin; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Rats; Rats, Sprague-Dawley; Serum

2012
Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:3-4

    Topics: Adenocarcinoma; Apoptosis; Catalase; Colonic Neoplasms; DNA Damage; Glutathione Peroxidase; Hesperidin; HT29 Cells; Humans; Lipid Peroxidation; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2012
Antiviral activity of four types of bioflavonoid against dengue virus type-2.
    Virology journal, 2011, Dec-28, Volume: 8

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Dengue; Dengue Virus; Flavanones; Flavonoids; Flavonols; Hesperidin; Inhibitory Concentration 50; Phytotherapy; Quercetin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Vero Cells; Virus Replication

2011
The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.
    The Journal of nutritional biochemistry, 2012, Volume: 23, Issue:10

    Topics: Animals; Aromatase; Aromatase Inhibitors; bcl-X Protein; Breast Neoplasms; Cell Proliferation; Citrus; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p57; Estradiol; Estrogens; Female; Hesperidin; Humans; MCF-7 Cells; Mice; Mice, Nude; Ovariectomy; RNA, Messenger; Xenograft Model Antitumor Assays

2012
Intravitreal kinetics of hesperidin, hesperetin, and hesperidin G: effect of dose and physicochemical properties.
    Journal of pharmaceutical sciences, 2012, Volume: 101, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Glucosides; Hesperidin; Male; Rabbits; Vitreous Body

2012
Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.
    Nutrients, 2010, Volume: 2, Issue:2

    Topics: Animals; Glucosyltransferases; Glycosides; Glycosylation; Hesperidin; Immunoglobulin E; Neutrophils; Rats; Xanthomonas campestris

2010
Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:3-4

    Topics: Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Citrus; Flavonoids; Hesperidin; Hydrolysis; Melanins; Melanoma, Experimental; Mice; Plant Extracts

2012
An investigation on the interaction of DNA with hesperetin/apigenin in the presence of CTAB by resonance Rayleigh light scattering technique and its analytical application.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2012, Volume: 90

    Topics: Apigenin; Cetrimonium; Cetrimonium Compounds; Detergents; DNA; Hesperidin; Hydrogen-Ion Concentration; Light; Limit of Detection; Spectrometry, Fluorescence; Vibration

2012
Interaction of antioxidant flavonoids with calf thymus DNA analyzed by spectroscopic and electrochemical methods.
    Journal of pharmaceutical and biomedical analysis, 2012, Apr-07, Volume: 63

    Topics: Antioxidants; Circular Dichroism; DNA; Electrochemical Techniques; Ethidium; Flavanones; Fluorescence Polarization; Hesperidin; Intercalating Agents; Molecular Structure; Nucleic Acid Conformation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectrum Analysis; Thermodynamics; Transition Temperature

2012
Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy.
    Molecular nutrition & food research, 2012, Volume: 56, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Biological Transport; Cell Line; Cytoprotection; Down-Regulation; Energy Metabolism; Glucose; Glucose Transporter Type 3; Glucose Transporter Type 4; Hesperidin; Mice; Neurons; Neuroprotective Agents; Peptide Fragments; Proto-Oncogene Proteins c-akt; RNA, Messenger

2012
Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
    Toxicology mechanisms and methods, 2012, Volume: 22, Issue:5

    Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Hesperidin; Male; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Vascular Endothelial Growth Factor A

2012
Protective effects of fermented Citrus unshiu peel extract against ultraviolet-A-induced photoageing in human dermal fibrobolasts.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:12

    Topics: beta-Galactosidase; Cells, Cultured; Citrus; Collagen; Dermis; Disaccharides; Fermentation; Fibroblasts; Flavanones; Fruit; Hesperidin; Humans; Matrix Metalloproteinase 1; Plant Extracts; Schizophyllum; Skin Aging; Ultraviolet Rays

2012
Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.
    Journal of natural products, 2012, Apr-27, Volume: 75, Issue:4

    Topics: ATP-Binding Cassette Transporters; Hesperidin; Humans; Lipoproteins, HDL; Liver X Receptors; Macrophages; Molecular Structure; Orphan Nuclear Receptors; PPAR gamma; RNA, Messenger

2012
Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.
    Bioscience, biotechnology, and biochemistry, 2012, Volume: 76, Issue:4

    Topics: Flavonoids; Gene Expression; Heat-Shock Proteins; Hesperidin; Membrane Proteins; Mitochondrial Proteins; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirtuin 2; Superoxide Dismutase; Time Factors

2012
Phytonutrient intake by adults in the United States in relation to fruit and vegetable consumption.
    Journal of the Academy of Nutrition and Dietetics, 2012, Volume: 112, Issue:2

    Topics: Adult; Antioxidants; Carotenoids; Cryptoxanthins; Diet; Ellagic Acid; Energy Intake; Feeding Behavior; Female; Fruit; Guidelines as Topic; Hesperidin; Humans; Interviews as Topic; Lycopene; Male; Micronutrients; Middle Aged; Nutrition Surveys; United States; Vegetables; Xanthophylls; Young Adult

2012
Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells.
    Food & function, 2012, Volume: 3, Issue:10

    Topics: Animals; Antioxidants; Cell Survival; Citrus; Cyclic AMP Response Element-Binding Protein; Hesperidin; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Neuroprotective Agents; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; PC12 Cells; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Rats; Receptors, Estrogen; RNA-Binding Proteins; Signal Transduction; Transcription Factors

2012
Evaluation of the intravenous and topical routes for ocular delivery of hesperidin and hesperetin.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2012, Volume: 28, Issue:6

    Topics: Administration, Ophthalmic; Animals; Benzalkonium Compounds; Biological Availability; Drug Delivery Systems; Excipients; Feasibility Studies; Glucuronides; Hesperidin; Hydrophobic and Hydrophilic Interactions; Injections, Intravenous; Male; Rabbits; Time Factors; Vitreous Body

2012
Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer.
    Phytotherapy research : PTR, 2013, Volume: 27, Issue:7

    Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Hesperidin; Male; Nucleolus Organizer Region; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar

2013
Anti-degranulating activity in rat basophil leukemia RBL-2H3 cells of flavanone glycosides and their aglycones in citrus fruits.
    Journal of natural medicines, 2013, Volume: 67, Issue:3

    Topics: Animals; Anti-Allergic Agents; Basophil Degranulation Test; Basophils; Calcium; Calcium Ionophores; Cell Degranulation; Cell Line, Tumor; Citrus; Disaccharides; Dose-Response Relationship, Drug; Flavanones; Glycosides; Hesperidin; Intracellular Signaling Peptides and Proteins; Leukemia; Phosphorylation; Plant Extracts; Plants, Medicinal; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; src-Family Kinases; Syk Kinase

2013
The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways.
    Fundamental & clinical pharmacology, 2013, Volume: 27, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; fas Receptor; Female; Flow Cytometry; Hesperidin; Humans; In Situ Nick-End Labeling; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Mitochondria; Real-Time Polymerase Chain Reaction; Time Factors; Uterine Cervical Neoplasms

2013
Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation.
    Pharmaceutical biology, 2012, Volume: 50, Issue:12

    Topics: Glucose; Glucosides; Glycation End Products, Advanced; Hesperidin; High-Throughput Screening Assays; Hypoglycemic Agents; Maillard Reaction; Molecular Structure; Pyruvaldehyde; Ribonuclease, Pancreatic; Serum Albumin, Bovine; Stereoisomerism; Structure-Activity Relationship

2012
7,3'-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis.
    Immunopharmacology and immunotoxicology, 2013, Volume: 35, Issue:1

    Topics: Animals; Apoptosis; Arthritis, Experimental; bcl-2-Associated X Protein; Hesperidin; Inflammation; Interleukin-1beta; Male; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Synovial Membrane; Tumor Necrosis Factor-alpha

2013
Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells.
    Cell biochemistry and function, 2013, Volume: 31, Issue:5

    Topics: Antigens, CD; Antineoplastic Agents, Phytogenic; Biological Transport; Cell Line, Tumor; Cell Proliferation; Female; Flavones; Gene Expression Regulation, Neoplastic; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Hesperidin; Humans; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction

2013
Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability.
    Journal of molecular recognition : JMR, 2012, Volume: 25, Issue:11

    Topics: Adsorption; Alginates; Aspergillus niger; Biological Availability; Buffers; Carrageenan; Chitosan; Cross-Linking Reagents; Drug Compounding; Enzymes, Immobilized; Fungal Proteins; Glucuronic Acid; Glutaral; Glycoside Hydrolases; Half-Life; Hesperidin; Hexuronic Acids; Hydrogels; Kinetics

2012
Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves.
    Journal of the science of food and agriculture, 2013, Volume: 93, Issue:6

    Topics: Camellia sinensis; Catechin; Citrus sinensis; Dietary Supplements; Flavonoids; Fruit; Hesperidin; Humans; Inhibitory Concentration 50; Plant Leaves; Rutin; Trypsin; Trypsin Inhibitors

2013
Pharmacokinetics of hesperetin and naringenin in the Zhi Zhu Wan, a traditional Chinese medicinal formulae, and its pharmacodynamics study.
    Phytotherapy research : PTR, 2013, Volume: 27, Issue:9

    Topics: Administration, Oral; Animals; Atractylodes; Chromatography, Liquid; Citrus; Drugs, Chinese Herbal; Flavanones; Gastrointestinal Motility; Hesperidin; Intestines; Male; Mice; Mice, Inbred ICR; Plasma; Tandem Mass Spectrometry

2013
Hesperetin: an inhibitor of the transforming growth factor-β (TGF-β) signaling pathway.
    European journal of medicinal chemistry, 2012, Volume: 58

    Topics: Antineoplastic Agents; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Hesperidin; Humans; Signal Transduction; Structure-Activity Relationship; Transforming Growth Factor beta; Tumor Cells, Cultured

2012
Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.
    British journal of pharmacology, 2013, Volume: 168, Issue:8

    Topics: Animals; Benzoin; Calcium; Calcium Channel Blockers; Calcium Signaling; Citrus; Drug Evaluation, Preclinical; Fabaceae; Flavanones; Ganglia, Spinal; HEK293 Cells; Hesperidin; Humans; Membrane Potentials; Mice; Mice, Inbred C57BL; Pregnenolone; Rats; Rats, Wistar; Secondary Metabolism; TRPM Cation Channels

2013
Assessment of phytochemical content in human milk during different stages of lactation.
    Nutrition (Burbank, Los Angeles County, Calif.), 2013, Volume: 29, Issue:1

    Topics: Adult; Carotenoids; Catechin; Cryptoxanthins; Female; Flavanones; Flavonoids; Hesperidin; Humans; Kaempferols; Lactation; Lutein; Lycopene; Milk, Human; Postpartum Period; Pregnancy; Quercetin; Time Factors; Xanthophylls; Zeaxanthins

2013
The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer.
    The Journal of nutritional biochemistry, 2013, Volume: 24, Issue:6

    Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Citrus; Estradiol; Female; Hesperidin; Humans; Letrozole; MCF-7 Cells; Mice; Mice, Nude; Nitriles; Osteoporosis; Selective Estrogen Receptor Modulators; Triazoles; Xenograft Model Antitumor Assays

2013
A comparison study on the binding of hesperetin and luteolin to bovine serum albumin by spectroscopy.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013, Feb-15, Volume: 103

    Topics: Animals; Binding Sites; Cattle; Drugs, Chinese Herbal; Hesperidin; Luteolin; Protein Binding; Protein Conformation; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics

2013
Flavanone metabolites decrease monocyte adhesion to TNF-α-activated endothelial cells by modulating expression of atherosclerosis-related genes.
    The British journal of nutrition, 2013, Volume: 110, Issue:4

    Topics: Atherosclerosis; Cell Adhesion; Endothelial Cells; Flavanones; Gene Expression Profiling; Gene Expression Regulation; Glucuronides; Hesperidin; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Monocytes; Sulfates; Tumor Necrosis Factor-alpha

2013
Prunin- and hesperetin glucoside-alkyl (C4-C18) esters interaction with Jurkat cells plasma membrane: consequences on membrane physical properties and antioxidant capacity.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 55

    Topics: Antioxidants; Cell Membrane; Esters; Hesperidin; Humans; Jurkat Cells; Phlorhizin

2013
Hesperetin rescues retinal oxidative stress, neuroinflammation and apoptosis in diabetic rats.
    Microvascular research, 2013, Volume: 87

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Aquaporin 4; Blood Glucose; Body Weight; Caspase 3; Catalase; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Glial Fibrillary Acidic Protein; Glutathione; Hesperidin; Immunohistochemistry; Inflammation; Inflammation Mediators; Interleukin-1beta; Male; Microscopy, Electron, Transmission; Oxidative Stress; Rats; Rats, Wistar; Retina; Streptozocin; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha

2013
5,7,3'-Triacetyl hesperetin suppresses adjuvant-induced arthritis in rats through modulating JAK2/STAT3 pathway.
    The American journal of Chinese medicine, 2013, Volume: 41, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Citrus; Edema; Freund's Adjuvant; Hesperidin; Interleukin-6; Janus Kinase 2; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Synovial Membrane

2013
Hesperetin protects against cardiac remodelling induced by pressure overload in mice.
    Journal of molecular histology, 2013, Volume: 44, Issue:5

    Topics: Animals; Body Weight; Cardiomegaly; Cardiotonic Agents; Fibrosis; Gene Expression Regulation; Heart; Hesperidin; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Organ Size; Oxidative Stress; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins c-akt; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Ventricular Pressure; Ventricular Remodeling

2013
Hesperetin alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of periodontal ligament stem cells.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Alkaline Phosphatase; beta Catenin; Cell Differentiation; Cells, Cultured; Gene Expression; Glucose; Hesperidin; Humans; Osteoblasts; Osteogenesis; Periodontal Ligament; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Stem Cells; Transcription Factors

2013
Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using felodipine and hesperetin in combination in Wistar rats and everted rat gut sacs in vitro.
    Phytotherapy research : PTR, 2014, Volume: 28, Issue:5

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cytochrome P-450 CYP3A; Felodipine; Half-Life; Hesperidin; Ileum; In Vitro Techniques; Intestinal Absorption; Male; Rats; Rats, Wistar; Verapamil

2014
Antianxiety-like effects of Chimpi (dried citrus peels) in the elevated open-platform test.
    Molecules (Basel, Switzerland), 2013, Aug-20, Volume: 18, Issue:8

    Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Citrus; Hesperidin; Male; Mice; Mice, Inbred ICR; Motor Activity

2013
Molecular mechanism underlying hesperetin-induced apoptosis by in silico analysis and in prostate cancer PC-3 cells.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:7

    Topics: Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Blotting, Western; Cell Proliferation; Hesperidin; Humans; Male; NF-kappa B; Prostatic Neoplasms; Protein Conformation; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2013
Simplified miniaturized ultrasound-assisted matrix solid phase dispersion extraction and high performance liquid chromatographic determination of seven flavonoids in citrus fruit juice and human fluid samples: hesperetin and naringenin as biomarkers.
    Journal of chromatography. A, 2013, Oct-11, Volume: 1311

    Topics: Beverages; Biomarkers; Chromatography, High Pressure Liquid; Citrus; Female; Flavanones; Fruit; Hesperidin; Humans; Limit of Detection; Male; Miniaturization; Solid Phase Extraction; Sound

2013
Production of hesperetin using a covalently multipoint immobilized diglycosidase from Acremonium sp. DSM24697.
    Journal of molecular microbiology and biotechnology, 2013, Volume: 23, Issue:6

    Topics: Acremonium; Enzymes, Immobilized; Glycoside Hydrolases; Hesperidin; Microspheres; Sepharose; Temperature; Time Factors

2013
Antimicrobial effect of 7-O-butylnaringenin, a novel flavonoid, and various natural flavonoids against Helicobacter pylori strains.
    International journal of environmental research and public health, 2013, Oct-28, Volume: 10, Issue:11

    Topics: Anti-Bacterial Agents; Flavanones; Flavonoids; Helicobacter pylori; Hesperidin; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Urease

2013
Molecular relaxation behavior and isothermal crystallization above glass transition temperature of amorphous hesperetin.
    Journal of pharmaceutical sciences, 2014, Volume: 103, Issue:1

    Topics: Crystallization; Glass; Hesperidin; Kinetics; Temperature; Transition Temperature

2014
Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
    Journal of agricultural and food chemistry, 2013, Nov-27, Volume: 61, Issue:47

    Topics: beta-Glucosidase; Citrus; Detergents; Disaccharides; Flavanones; Flavonoids; Food Industry; Glycosides; Hesperidin; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Plant Extracts; Pyrococcus furiosus; Solvents; Substrate Specificity; Temperature

2013
Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis.
    Fitoterapia, 2014, Volume: 92

    Topics: Animals; Biological Transport; Citrus; Diabetes Mellitus, Type 2; Flavanones; Gluconeogenesis; Glucose; Hesperidin; Hyperglycemia; Hypoglycemic Agents; Liver; Mitochondria; Phytotherapy; Plant Extracts; Pyruvic Acid; Rats; Rats, Wistar; Structure-Activity Relationship

2014
Citrus flavanones affect hepatic fatty acid oxidation in rats by acting as prooxidant agents.
    BioMed research international, 2013, Volume: 2013

    Topics: Animals; Antioxidants; Citrus; Flavanones; Hepatocytes; Hesperidin; Humans; Lipid Metabolism; Liver; Male; Mitochondria, Liver; Oxidation-Reduction; Peroxisomes; Rats; Reactive Oxygen Species

2013
Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats.
    Journal of nutritional science and vitaminology, 2013, Volume: 59, Issue:5

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Dietary Supplements; Endothelium, Vascular; Enzyme Repression; Glucosides; Hesperidin; Hypertension; In Vitro Techniques; Male; NADPH Oxidases; Protein Subunits; Random Allocation; Rats; Rats, Inbred SHR; Solubility; Thromboxane B2; Thromboxane-A Synthase; Vascular Resistance

2013
Hesperetin activates the Notch1 signaling cascade, causes apoptosis, and induces cellular differentiation in anaplastic thyroid cancer.
    Annals of surgical oncology, 2014, Volume: 21 Suppl 4

    Topics: Adenosine Triphosphatases; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Gene Expression; Hesperidin; Homeodomain Proteins; Humans; Nuclear Proteins; Paired Box Transcription Factors; PAX8 Transcription Factor; Receptor, Notch1; Receptors, Thyrotropin; Signal Transduction; Symporters; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Thyroid Nuclear Factor 1; Transcription Factor HES-1; Transcription Factors

2014
Hesperetin attenuates mitochondria-dependent apoptosis in lipopolysaccharide-induced H9C2 cardiomyocytes.
    Molecular medicine reports, 2014, Volume: 9, Issue:5

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line; Cell Survival; Hesperidin; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Mitochondria; Myocytes, Cardiac; Rats; Signal Transduction

2014
Protective effect of hesperetin and naringenin against apoptosis in ischemia/reperfusion-induced retinal injury in rats.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: Animals; Apoptosis; Flavanones; Hesperidin; Male; Rats; Rats, Wistar; Reperfusion Injury; Retina

2014
UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.
    Journal of natural products, 2014, Apr-25, Volume: 77, Issue:4

    Topics: Arizona; Biological Products; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Databases, Factual; Diterpenes; Flavones; Hesperidin; Mass Spectrometry; Molecular Conformation; Molecular Structure; Plant Leaves; Small Molecule Libraries; Thuja

2014
Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.
    Mediators of inflammation, 2014, Volume: 2014

    Topics: Aggregatibacter actinomycetemcomitans; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Differentiation; Cells, Cultured; Cytokines; Escherichia coli; Hesperidin; Humans; I-kappa B Proteins; Inflammation; Leukocytes; Leukocytes, Mononuclear; Lipopolysaccharides; Monocytes; Neutrophils; NF-KappaB Inhibitor alpha; Phloretin; Resveratrol; RNA, Messenger; Silymarin; Stilbenes

2014
Nanosuspensions of hesperetin: preparation and characterization.
    Die Pharmazie, 2014, Volume: 69, Issue:3

    Topics: Chemistry, Pharmaceutical; Drug Stability; Electrochemistry; Hesperidin; Light; Nanoparticles; Nanostructures; Particle Size; Preservatives, Pharmaceutical; Scattering, Radiation; Surface-Active Agents; Suspensions

2014
Rhizobium tibeticum activated with a mixture of flavonoids alleviates nickel toxicity in symbiosis with fenugreek (Trigonella foenum graecum L.).
    Ecotoxicology (London, England), 2014, Volume: 23, Issue:5

    Topics: Apigenin; Flavonoids; Glutamate-Ammonia Ligase; Hesperidin; Nickel; Nitrogen Fixation; Nod Signaling Adaptor Proteins; Phenylalanine Ammonia-Lyase; Plant Exudates; Plant Root Nodulation; Random Allocation; Rhizobium; Stress, Physiological; Symbiosis; Trigonella

2014
Hesperetin inhibits rat coronary constriction by inhibiting Ca(2+) influx and enhancing voltage-gated K(+) channel currents of the myocytes.
    European journal of pharmacology, 2014, Jul-15, Volume: 735

    Topics: Animals; Calcium; Coronary Vessels; Hesperidin; In Vitro Techniques; Male; Myocardial Contraction; Myocytes, Smooth Muscle; Potassium Channels, Voltage-Gated; Rats, Wistar; Vasoconstriction

2014
Mechanism of peroxisome proliferator-activated receptor gamma (PPARγ) transactivation by hesperetin glucuronides is distinct from that by a thiazolidine-2,4-dione agent.
    Chemical & pharmaceutical bulletin, 2014, Volume: 62, Issue:5

    Topics: Animals; Binding Sites; Cells, Cultured; Chlorocebus aethiops; COS Cells; Hesperidin; Humans; Models, Molecular; Molecular Structure; PPAR gamma; Structure-Activity Relationship; Thiazolidinediones

2014
The effect of hesperetin on ischemia-reperfusion injury in rat ovary.
    Archives of gynecology and obstetrics, 2014, Volume: 290, Issue:4

    Topics: Animals; Apoptosis; Caspase 3; Dimethyl Sulfoxide; Edema; Female; Hemorrhage; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Ovary; Rats, Wistar; Reperfusion; Reperfusion Injury; Solvents; Torsion, Mechanical

2014
Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity.
    Pharmacology, biochemistry, and behavior, 2014, Volume: 124

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Female; Hesperidin; Male; Neuralgia; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Tumor Necrosis Factor-alpha

2014
A flavonoid fraction purified from Rutaceae aurantiae (Daflon(R)) inhibiting AGE formation, reduces urinary albumin clearance and corrects hypoalbuminemia in normotensive and hypertensive diabetic rats.
    Diabetes research and clinical practice, 2014, Volume: 105, Issue:3

    Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diosmin; Flavonoids; Fructosamine; Glomerular Basement Membrane; Glycation End Products, Advanced; Hesperidin; Hyperglycemia; Hypoalbuminemia; Kidney Glomerulus; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Rats, Inbred SHR; Rats, Wistar; Rutaceae

2014
Hesperetin glucuronides induce adipocyte differentiation via activation and expression of peroxisome proliferator-activated receptor-γ.
    Bioscience, biotechnology, and biochemistry, 2014, Volume: 78, Issue:6

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Chlorocebus aethiops; Chromans; COS Cells; Drug Synergism; Gene Expression Regulation; Glucuronides; Hesperidin; Mice; PPAR gamma; Protein Structure, Tertiary; Thiazolidinediones; Troglitazone

2014
Encapsulation and micronization effectively improve orange beverage flavanone bioavailability in humans.
    Journal of agricultural and food chemistry, 2014, Oct-01, Volume: 62, Issue:39

    Topics: Adult; Beverages; Biological Availability; Citrus sinensis; Drug Compounding; Hesperidin; Humans; Male; Middle Aged; Particle Size

2014
Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway.
    Journal of cellular physiology, 2015, Volume: 230, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Enzyme Activation; Flow Cytometry; Hesperidin; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; MCF-7 Cells; Membrane Potential, Mitochondrial; Reactive Oxygen Species; RNA, Small Interfering; Transfection

2015
[Effect of different compatibility of zhizi dahuang decoction on pharmacokinetics of naringenin and hesperetin].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014, Volume: 39, Issue:13

    Topics: Animals; Chromatography, High Pressure Liquid; Citrus; Drug Incompatibility; Drug Interactions; Drugs, Chinese Herbal; Flavanones; Gardenia; Hesperidin; Rats; Rats, Sprague-Dawley

2014
Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis.
    Journal of biochemical and molecular toxicology, 2015, Volume: 29, Issue:3

    Topics: Adipogenesis; Apoptosis; bcl-2-Associated X Protein; Hesperidin; Humans; Lipolysis; Mesenchymal Stem Cells; Proto-Oncogene Proteins p21(ras)

2015
Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells.
    Enzyme and microbial technology, 2015, Volume: 68

    Topics: Acetophenones; Arbutin; Benzopyrans; Cell Line, Tumor; Drug Evaluation, Preclinical; Enzyme Induction; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genes, Synthetic; Green Fluorescent Proteins; Hesperidin; Humans; Intramolecular Oxidoreductases; Melanins; Melanoma; Melanoma, Experimental; Microphthalmia-Associated Transcription Factor; Microscopy, Fluorescence; Monophenol Monooxygenase; Neoplasm Proteins; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; Skin Lightening Preparations; Theophylline; Transfection

2015
Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: in vitro and in vivo investigations.
    International journal of pharmaceutics, 2014, Dec-30, Volume: 477, Issue:1-2

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Survival; Deoxycholic Acid; Drug Carriers; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Stability; Female; Flavanones; Hesperidin; Humans; Hyaluronic Acid; Male; MCF-7 Cells; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitoxantrone; Nanoparticles; Neoplasm Proteins; Particle Size; Quercetin; Rats, Wistar; Surface Properties; Tissue Distribution

2014
Chelating ability and biological activity of hesperetin Schiff base.
    Journal of inorganic biochemistry, 2015, Volume: 143

    Topics: Chelating Agents; Copper; DNA; Flavanones; Hesperidin; Plasmids; Schiff Bases

2015
[Hesperetin attenuates angiotensin II-induced collagen expression in cardiac fibroblasts in vitro].
    Zhonghua yi xue za zhi, 2014, Sep-30, Volume: 94, Issue:36

    Topics: Angiotensin II; Cell Proliferation; Collagen; Fibroblasts; Gene Expression; Heart; Hesperidin; In Vitro Techniques; Matrix Metalloproteinase 1; Reactive Oxygen Species

2014
In vitro colonic catabolism of orange juice (poly)phenols.
    Molecular nutrition & food research, 2015, Volume: 59, Issue:3

    Topics: Adult; Beverages; Chromatography, High Pressure Liquid; Citrus sinensis; Colon; Coumaric Acids; Feces; Female; Fermentation; Flavanones; Gas Chromatography-Mass Spectrometry; Hesperidin; Humans; In Vitro Techniques; Male; Polyphenols

2015
Effects of the flavanone combination hesperetin-naringenin, and orange and grapefruit juices, on airway inflammation and remodeling in a murine asthma model.
    Phytotherapy research : PTR, 2015, Volume: 29, Issue:4

    Topics: Airway Remodeling; Animals; Asthma; Beverages; Bronchoalveolar Lavage Fluid; Citrus paradisi; Citrus sinensis; Disease Models, Animal; Eosinophils; Flavanones; Fruit; Hesperidin; Inflammation; Lung; Macrophages; Male; Mice; Mice, Inbred BALB C

2015
Biological activity of natural flavonoids as impacted by protein flexibility: an example of flavanones.
    Molecular bioSystems, 2015, Volume: 11, Issue:4

    Topics: Binding Sites; Flavanones; Hesperidin; Humans; Molecular Docking Simulation; Pliability; Protein Binding; Protein Conformation; Serum Albumin

2015
Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities.
    Journal of the science of food and agriculture, 2016, Volume: 96, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Free Radical Scavengers; HeLa Cells; Hesperidin; Humans; Hydroquinones; Origanum; Oxidation-Reduction; Phenols; Plant Components, Aerial; Plant Extracts; Rats

2016
Evaluation of topical hesperetin matrix film for back-of-the-eye delivery.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2015, Volume: 92

    Topics: Administration, Topical; Animals; Cornea; Drug Compounding; Drug Delivery Systems; Drug Liberation; Eye; Hesperidin; Male; Polyethylene Glycols; Rabbits; Time Factors; Tissue Distribution

2015
Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium.
    Medical oncology (Northwood, London, England), 2015, Volume: 32, Issue:4

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Calcium; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cell Proliferation; Cytoplasm; Hesperidin; Humans; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Reactive Oxygen Species; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2015
Hesperetin induces melanin production in adult human epidermal melanocytes.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2015, Volume: 80

    Topics: Animals; Cell Line; Epidermal Cells; Hesperidin; Humans; Melanins; Melanocytes; Melanoma; Mice; Molecular Structure

2015
Oral bioavailability and pharmacodynamic activity of hesperetin nanocrystals generated using a novel bottom-up technology.
    Molecular pharmaceutics, 2015, Apr-06, Volume: 12, Issue:4

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Caco-2 Cells; Calorimetry, Differential Scanning; Carrageenan; Chemistry, Pharmaceutical; Crystallization; Crystallography, X-Ray; Female; Hesperidin; Humans; Mannitol; MCF-7 Cells; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Technology, Pharmaceutical; Thermogravimetry; Tumor Necrosis Factor-alpha; X-Ray Diffraction

2015
Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women.
    The Journal of nutrition, 2015, Volume: 145, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Caffeic Acids; Case-Control Studies; Catechin; Coumaric Acids; Diabetes Mellitus, Type 2; Female; Flavanones; Follow-Up Studies; Hesperidin; Humans; Hydroxybenzoates; Middle Aged; Nutrition Assessment; Polyphenols; Prospective Studies; Quercetin; Risk Factors; Surveys and Questionnaires

2015
Preparation, characterization and application of molecularly imprinted monolithic column for hesperetin.
    Journal of pharmaceutical and biomedical analysis, 2015, Volume: 111

    Topics: Acrylamide; Adsorption; Chromatography, High Pressure Liquid; Citrus; Hesperidin; Medicine, Chinese Traditional; Methanol; Molecular Imprinting; Plant Extracts; Polymerization; Polymers; Rutin; Solid Phase Extraction

2015
Evaluation of Antitumor Activity of Hesperetin-Loaded Nanoparticles Against DMBA-Induced Oral Carcinogenesis Based on Tissue Autofluorescence Spectroscopy and Multivariate Analysis.
    Journal of fluorescence, 2015, Volume: 25, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Hesperidin; Male; Mesocricetus; Mouth Neoplasms; Multivariate Analysis; Nanoparticles; ROC Curve; Spectrometry, Fluorescence

2015
Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species.
    Digestive diseases and sciences, 2015, Volume: 60, Issue:10

    Topics: Analysis of Variance; Animals; Apoptosis; Blotting, Western; Cell Proliferation; Female; Hesperidin; Heterografts; Humans; In Situ Nick-End Labeling; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Reactive Oxygen Species; Reference Values; Stomach Neoplasms; Tumor Cells, Cultured

2015
Validation of RP-HPLC Method for Simultaneous Quantification of Bicalutamide and Hesperetin in Polycaprolactone-Bicalutamide-Hesperetin-Chitosan Nanoparticles.
    Journal of chromatographic science, 2015, Volume: 53, Issue:9

    Topics: Anilides; Antineoplastic Agents; Chitosan; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Hesperidin; Limit of Detection; Linear Models; Nanoparticles; Nitriles; Polyesters; Reproducibility of Results; Tosyl Compounds

2015
The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:11

    Topics: Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Flavonoids; Flavonols; Gene Expression Regulation, Neoplastic; Hesperidin; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Membrane Potential, Mitochondrial; Neoplasm Proteins; Signal Transduction

2015
Effect of Mannitol on Nucleation and Crystal Growth of Amorphous Flavonoids: Implications on the Formation of Nanocrystalline Solid Dispersion.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:11

    Topics: Calorimetry, Differential Scanning; Crystallization; Excipients; Flavanones; Hesperidin; Kinetics; Mannitol; Phase Transition; Powder Diffraction; Thermodynamics; X-Ray Diffraction

2015
Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2015, Oct-12, Volume: 78

    Topics: Anti-Inflammatory Agents; Caco-2 Cells; Flavanones; Hesperidin; Humans; Intestinal Absorption; Monocarboxylic Acid Transporters; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins

2015
Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Controls Efflux Transport of Hesperetin Sulfates in Sulfotransferase 1A3-Overexpressing Human Embryonic Kidney 293 Cells.
    Drug metabolism and disposition: the biological fate of chemicals, 2015, Volume: 43, Issue:10

    Topics: Animals; Arylsulfotransferase; Biological Transport; HEK293 Cells; Hesperidin; Humans; Liver; Multidrug Resistance-Associated Proteins; Rats; Sulfates

2015
Single Dose Oral and Intravenous Pharmacokinetics and Tissue Distribution of a Novel Hesperetin Derivative MTBH in Rats.
    European journal of drug metabolism and pharmacokinetics, 2016, Volume: 41, Issue:6

    Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Carbon Tetrachloride Poisoning; Dose-Response Relationship, Drug; Drug Stability; Glucuronides; Half-Life; Hesperidin; Injections, Intravenous; Male; Protective Agents; Random Allocation; Rats, Sprague-Dawley; Sulfates; Tissue Distribution

2016
Hesperetin prevents selenite-induced cataract in rats.
    Molecular vision, 2015, Volume: 21

    Topics: Animals; Antioxidants; Ascorbic Acid; Cataract; Disease Models, Animal; Eye Proteins; Female; Free Radical Scavengers; Glutathione; Hesperidin; Intermediate Filament Proteins; Lens, Crystalline; Oxidative Stress; Proteolysis; Rats; Rats, Sprague-Dawley; Sodium Selenite

2015
[Simultaneous determination of 11 constituents in Citrus reticulate 'Chachi' by high performance liquid chromatography].
    Se pu = Chinese journal of chromatography, 2015, Volume: 33, Issue:4

    Topics: Apigenin; Chromatography, High Pressure Liquid; Citrus; Flavones; Flavonoids; Furaldehyde; Glucosides; Hesperidin

2015
Hesperetin Modifies the Composition of Fecal Microbiota and Increases Cecal Levels of Short-Chain Fatty Acids in Rats.
    Journal of agricultural and food chemistry, 2015, Sep-16, Volume: 63, Issue:36

    Topics: Animals; Bacteria; Cecum; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Hesperidin; Male; Rats; Rats, Wistar

2015
Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an in vitro and in vivo study.
    Journal of molecular recognition : JMR, 2016, Volume: 29, Issue:2

    Topics: Animals; Antioxidants; Gene Expression Regulation, Enzymologic; Hesperidin; In Vitro Techniques; Lipids; Liver; Male; Rats; Rats, Wistar; Superoxide Dismutase; Xanthine Oxidase

2016
Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury.
    Japanese journal of ophthalmology, 2016, Volume: 60, Issue:1

    Topics: Animals; Biomarkers; Blotting, Western; Disease Models, Animal; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Interleukin-1beta; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Solubility; Water

2016
Fisetin and hesperetin induced apoptosis and cell cycle arrest in chronic myeloid leukemia cells accompanied by modulation of cellular signaling.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Flavonoids; Flavonols; Gene Expression Regulation, Leukemic; Gene Regulatory Networks; Genome-Wide Association Study; Hesperidin; Humans; K562 Cells; Membrane Potential, Mitochondrial; Neoplasm Proteins

2016
Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Esophageal Neoplasms; Female; Glutathione; Hesperidin; Humans; Mice; Mice, Inbred BALB C; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species

2016
Hesperetin and its sulfate and glucuronide metabolites inhibit TNF-α induced human aortic endothelial cell migration and decrease plasminogen activator inhibitor-1 (PAI-1) levels.
    Food & function, 2016, Volume: 7, Issue:1

    Topics: Aorta; Cell Line; Cell Movement; Citrus sinensis; Endothelial Cells; Fruit; Glucuronides; Hesperidin; Humans; Inflammation; Interleukin-6; Interleukin-8; Plasminogen Activator Inhibitor 1; Sulfates; Tumor Necrosis Factor-alpha

2016
Scavenging of Toxic Acrolein by Resveratrol and Hesperetin and Identification of Adducts.
    Journal of agricultural and food chemistry, 2015, Nov-04, Volume: 63, Issue:43

    Topics: Acrolein; Antioxidants; Hesperidin; Hydrogen-Ion Concentration; Molecular Structure; Resveratrol; Stilbenes

2015
Hesperetin Liposomes for Cancer Therapy.
    Current drug delivery, 2016, Volume: 13, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cholesterol; Drug Compounding; Drug Resistance, Neoplasm; Female; Hesperidin; Humans; Kinetics; Liposomes; Lung Neoplasms; Phosphatidylcholines; Polyethylene Glycols; Solubility; Transfection

2016
Hesperetin exerts apoptotic effect on A431 skin carcinoma cells by regulating mitogen activated protein kinases and cyclins.
    Cellular and molecular biology (Noisy-le-Grand, France), 2015, Oct-30, Volume: 61, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Survival; Cyclins; Hesperidin; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Skin Neoplasms

2015
Pharmacokinetic interaction study between flavanones (hesperetin, naringenin) and rasagiline mesylate in wistar rats.
    Drug development and industrial pharmacy, 2016, Volume: 42, Issue:7

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cytochrome P-450 CYP1A2; Drug Interactions; Flavanones; Hesperidin; Indans; Male; Monoamine Oxidase Inhibitors; Rats, Wistar; Spinal Cord; Tissue Distribution

2016
Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
    Chemico-biological interactions, 2015, Dec-05, Volume: 242

    Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Carcinogenesis; Cell Proliferation; Cytochrome P-450 CYP1A1; Hesperidin; Lipid Peroxidation; Lung; Male; Mice; NF-E2-Related Factor 2; NF-kappa B; Proliferating Cell Nuclear Antigen; Tumor Necrosis Factor-alpha

2015
A HPLC-MS/MS method for the quantitation of free, conjugated, and total HDND-7, a novel hesperetin derivative, in rat plasma and tissues: Application to the pharmacokinetic and tissue distribution study.
    Journal of pharmaceutical and biomedical analysis, 2016, Jan-25, Volume: 118

    Topics: Animals; Chromatography, High Pressure Liquid; Hesperidin; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution

2016
Copper(II) complexes with naringenin and hesperetin: cytotoxic activity against A 549 human lung adenocarcinoma cells and investigation on the mode of action.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2016, Volume: 29, Issue:1

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Coordination Complexes; Copper; DNA; Fibroblasts; Flavanones; Hesperidin; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms

2016
Hesperetin attenuates ventilator-induced acute lung injury through inhibition of NF-κB-mediated inflammation.
    European journal of pharmacology, 2015, Dec-15, Volume: 769

    Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Survival; Cytokines; Gene Expression Regulation; Hesperidin; Inflammation; Lung; Macrophages; Male; Peroxidase; PPAR gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor RelA; Ventilator-Induced Lung Injury

2015
Simple low-cost miniaturization approach for pharmaceutical nanocrystals production.
    International journal of pharmaceutics, 2016, Mar-30, Volume: 501, Issue:1-2

    Topics: Apigenin; Ascorbic Acid; Chemistry, Pharmaceutical; Cyclosporine; Hesperidin; Miniaturization; Nanoparticles; Particle Size; Resveratrol; Stilbenes; Suspensions; Technology, Pharmaceutical

2016
Effects of hesperetin on platelet-derived growth factor-BB-induced pulmonary artery smooth muscle cell proliferation.
    Molecular medicine reports, 2016, Volume: 13, Issue:1

    Topics: Animals; Becaplermin; Cell Proliferation; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hesperidin; Humans; Myocytes, Smooth Muscle; Oncogene Protein v-akt; Primary Cell Culture; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Rats; Signal Transduction

2016
Host-guest system of hesperetin and β-cyclodextrin or its derivatives: Preparation, characterization, inclusion mode, solubilization and stability.
    Materials science & engineering. C, Materials for biological applications, 2016, Volume: 59

    Topics: Cyclodextrins; Drug Stability; Hesperidin; Nuclear Magnetic Resonance, Biomolecular; Solubility

2016
Biotransformation effects on anti lipogenic activity of citrus extracts.
    Food chemistry, 2016, Apr-15, Volume: 197 Pt B

    Topics: Adipocytes; Animals; Citrus; Flavanones; Hesperidin; Lipolysis; Mice; Plant Extracts

2016
Protective Effect of Oral Hesperetin Against Unilateral Striatal 6-Hydroxydopamine Damage in the Rat.
    Neurochemical research, 2016, Volume: 41, Issue:5

    Topics: Administration, Oral; Animals; Apoptosis; Corpus Striatum; Glial Fibrillary Acidic Protein; Gliosis; Hesperidin; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Oxidopamine; Parkinson Disease; Rats, Wistar

2016
Simultaneous Chiral Separation of Flavanone, Naringenin, and Hesperetin Enantiomers by RP-UHPLC-DAD.
    Chirality, 2016, Volume: 28, Issue:2

    Topics: Amylose; Chromatography, High Pressure Liquid; Flavanones; Hesperidin; Molecular Structure; Phenylcarbamates; Stereoisomerism

2016
The novel voltammetric method for determination of hesperetin based on a sensitive electrochemical sensor.
    Talanta, 2016, Apr-01, Volume: 150

    Topics: Calibration; Electrochemistry; Electrodes; Glass; Graphite; Hesperidin; Humans; Hydrogen-Ion Concentration; Limit of Detection; Nanotubes, Carbon; Oxidation-Reduction; Oxides; Reproducibility of Results; Time Factors

2016
Hesperetin derivatives: Synthesis and anti-inflammatory activity.
    Bioorganic & medicinal chemistry letters, 2016, Mar-01, Volume: 26, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Hesperidin; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2016
Isolation and characterization of wound-induced compounds from the leaves of Citrus hassaku.
    Journal of bioscience and bioengineering, 2016, Volume: 122, Issue:2

    Topics: Anti-Bacterial Agents; Citrus; Furans; Hesperidin; Lignans; Magnetic Resonance Spectroscopy; Plant Diseases; Plant Leaves; Spectrometry, Mass, Electrospray Ionization; Wounds and Injuries

2016
Chemical Evidence for Potent Xanthine Oxidase Inhibitory Activity of Ethyl Acetate Extract of Citrus aurantium L. Dried Immature Fruits.
    Molecules (Basel, Switzerland), 2016, Mar-02, Volume: 21, Issue:3

    Topics: Acetates; Citrus; Enzyme Inhibitors; Flavanones; Flavones; Fruit; Hesperidin; Humans; Hyperuricemia; In Vitro Techniques; Molecular Structure; Phytotherapy; Plant Extracts; Xanthine Oxidase

2016
Hesperetin Suppresses Inflammatory Responses in Lipopolysaccharide-Induced RAW 264.7 Cells via the Inhibition of NF-κB and Activation of Nrf2/HO-1 Pathways.
    Inflammation, 2016, Volume: 39, Issue:3

    Topics: Animals; Enzyme Activation; Gene Expression Regulation; Heme Oxygenase-1; Hesperidin; Inflammation; Lipopolysaccharides; Mice; NF-E2-Related Factor 2; NF-kappa B; RAW 264.7 Cells

2016
Enhanced anti-oxidative effect of fermented Korean mistletoe is originated from an increase in the contents of caffeic acid and lyoniresinol.
    Food & function, 2016, May-18, Volume: 7, Issue:5

    Topics: Animals; Anisoles; Antioxidants; Aspergillus; Benzaldehydes; Caffeic Acids; Cell Line; Chromatography, High Pressure Liquid; Fermentation; Free Radical Scavengers; Glutamic Acid; Herbal Medicine; Hesperidin; Mice; Mistletoe; Naphthalenes; Neuroprotective Agents; Plant Extracts; Solvents

2016
Phytochemical analysis, antimicrobial, antioxidant activities and total phenols of Ferulago carduchorum in two vegetative stages (flower and fruit).
    Pakistan journal of pharmaceutical sciences, 2016, Volume: 29, Issue:2

    Topics: Anti-Infective Agents; Antioxidants; Apiaceae; Bacteria; Biphenyl Compounds; Flowers; Fruit; Fungi; Hesperidin; Microbial Sensitivity Tests; Phenols; Phytotherapy; Picrates; Plant Extracts; Plants, Medicinal; Solvents

2016
Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model.
    International journal of pediatric otorhinolaryngology, 2016, Volume: 85

    Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Proliferation; Cisplatin; Cochlea; Disease Models, Animal; Ear, Inner; Hearing Loss; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Male; Otoacoustic Emissions, Spontaneous; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Signal-To-Noise Ratio; Spiral Ganglion

2016
The individual or combinational effects of Hesperetin and Letrozole on the activity and expression of aromatase in MCF-7 cells.
    Cellular and molecular biology (Noisy-le-Grand, France), 2016, May-30, Volume: 62, Issue:6

    Topics: Aromatase; Cell Survival; Enzyme Assays; Estradiol; Hesperidin; Humans; Letrozole; MCF-7 Cells; Nitriles; Real-Time Polymerase Chain Reaction; Triazoles

2016
Role of hesperetin in LDL-receptor expression in hepatoma HepG2 cells.
    BMC complementary and alternative medicine, 2016, Jun-27, Volume: 16

    Topics: Gene Expression; Hep G2 Cells; Hesperidin; Humans; Liver Neoplasms; Receptors, LDL; Sterol Regulatory Element Binding Proteins

2016
Inhibitory effects of hesperetin on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K(+) current in human atrial myocytes.
    European journal of pharmacology, 2016, Oct-15, Volume: 789

    Topics: Dose-Response Relationship, Drug; Electrophysiological Phenomena; Gene Expression; Heart Atria; HEK293 Cells; Hesperidin; Humans; Ion Channel Gating; Kinetics; Kv1.5 Potassium Channel; Myocytes, Cardiac; Potassium; Potassium Channel Blockers

2016
Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors.
    Life sciences, 2016, Sep-01, Volume: 160

    Topics: Cell Cycle; Cell Line, Tumor; Flavanones; Genes, erbB-2; Hesperidin; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases

2016
Development and validation of a RP-UHPLC-ESI-MS/MS method for the chiral separation and determination of flavanone, naringenin and hesperetin enantiomers.
    Talanta, 2016, Oct-01, Volume: 159

    Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Flavanones; Hesperidin; Reproducibility of Results; Tandem Mass Spectrometry

2016
Intestinal transport of HDND-7, a novel hesperetin derivative, in in vitro MDCK cell and in situ single-pass intestinal perfusion models.
    Xenobiotica; the fate of foreign compounds in biological systems, 2017, Volume: 47, Issue:8

    Topics: Administration, Oral; Animals; Biological Availability; Biological Transport; Dogs; Hesperidin; Intestinal Mucosa; Madin Darby Canine Kidney Cells; Rats

2017
Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats.
    Experimental gerontology, 2016, Volume: 84

    Topics: Aging; Animals; Antioxidants; Citrus; Flavanones; Gene Expression; Hesperidin; Lipid Peroxidation; Liver; Male; Oxidative Stress; Phospholipids; Plant Oils; Rats; Rats, Wistar; Sunflower Oil; Thiobarbituric Acid Reactive Substances

2016
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro.
    British journal of pharmacology, 2017, Volume: 174, Issue:1

    Topics: Animals; Biological Products; Concanavalin A; Dose-Response Relationship, Drug; Galactosamine; Hesperidin; In Vitro Techniques; Lipopolysaccharides; Liver Failure, Acute; Male; Protective Agents; Rats; Rats, Wistar

2017
Antispasmodic effect of selected Citrus flavonoids on rat isolated jejunum specimens.
    European journal of pharmacology, 2016, Nov-15, Volume: 791

    Topics: Animals; Citrus; Hesperidin; Jejunum; Male; Muscle Contraction; Rats; Rats, Wistar; Spasm

2016
Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus.
    European journal of nutrition, 2018, Volume: 57, Issue:1

    Topics: Bifidobacterium longum; Citrus sinensis; Flavanones; Fruit; Fruit and Vegetable Juices; Glucosidases; Hesperidin; Intestinal Absorption; Lacticaseibacillus rhamnosus; Probiotics

2018
Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats.
    Toxicology and industrial health, 2017, Volume: 33, Issue:5

    Topics: Acetylcholinesterase; Animals; Antioxidants; Apoptosis; Brain; Brain Chemistry; Cadmium; Hesperidin; Lipid Peroxidation; Male; Mitochondria; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar

2017
Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway.
    Toxicology, 2017, 04-15, Volume: 381

    Topics: Actins; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Aspartate Aminotransferases; Cell Line; Cell Proliferation; Collagen Type I; Collagen Type I, alpha 1 Chain; Hepatic Stellate Cells; Hesperidin; Liver Cirrhosis; Male; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta1

2017
Synthesis and biological evaluation of hesperetin derivatives as agents inducing apoptosis.
    Bioorganic & medicinal chemistry, 2017, 01-01, Volume: 25, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Caspase 3; Caspase 9; Colony-Forming Units Assay; HCT116 Cells; Hesperidin; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Molecular Docking Simulation; Molecular Structure; Poly (ADP-Ribose) Polymerase-1

2017
Chronic exposure to short-chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells.
    The Journal of nutritional biochemistry, 2017, Volume: 39

    Topics: Acetates; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Butyrates; Caco-2 Cells; Coumaric Acids; Fatty Acids, Volatile; Gastrointestinal Microbiome; Glucuronosyltransferase; Hesperidin; Humans; Intestinal Mucosa; Lactates; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasm Proteins; Polyphenols; Propionates; Symporters

2017
Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions.
    Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:12

    Topics: Animals; Cell Line; Citrus; Flavanones; Glucuronosyltransferase; Herb-Drug Interactions; Hesperidin; Humans; Hymecromone; Insecta; Recombinant Proteins; Trifluoperazine

2016
Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism.
    Materials science & engineering. C, Materials for biological applications, 2017, Feb-01, Volume: 71

    Topics: Anilides; Animals; Hesperidin; Humans; Male; Nitriles; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Tosyl Compounds

2017
Hesperetin-etoposide combinations induce cytotoxicity in U2OS cells: Implications on therapeutic developments for osteosarcoma.
    DNA repair, 2017, Volume: 50

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cytotoxins; Doxorubicin; Etoposide; Hesperidin; Humans; Osteosarcoma

2017
Hesperetin protects against H
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88

    Topics: Antioxidant Response Elements; Antioxidants; Cell Death; Cell Line; Epithelial Cells; Glutathione; Heme Oxygenase-1; Hesperidin; Humans; Hydrogen Peroxide; Kelch-Like ECH-Associated Protein 1; Malondialdehyde; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; RNA, Small Interfering; Signal Transduction; Superoxide Dismutase; Transfection; Up-Regulation

2017
Structure-activity relationship of flavanone. Anti-degranulation activity of 7-O-substituted hesperetin.
    Natural product research, 2017, Volume: 31, Issue:18

    Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Flavanones; Hesperidin; Rats; Structure-Activity Relationship

2017
The renoprotective activity of hesperetin in cisplatin induced nephrotoxicity in rats: Molecular and biochemical evidence.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89

    Topics: Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Cisplatin; Creatinine; Flavonoids; Hesperidin; Inflammation; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Oxidative Stress; Protective Agents; Rats; Rats, Wistar

2017
Inhibitory effect of hesperetin on α-glucosidase: Molecular dynamics simulation integrating inhibition kinetics.
    International journal of biological macromolecules, 2017, Volume: 101

    Topics: alpha-Glucosidases; Glycoside Hydrolase Inhibitors; Hesperidin; Kinetics; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Structure, Tertiary; Saccharomyces cerevisiae

2017
Use of multiresponse statistical techniques to optimize the separation of diosmin, hesperidin, diosmetin and hesperitin in different pharmaceutical preparations by high performance liquid chromatography with UV-DAD.
    Talanta, 2017, May-15, Volume: 167

    Topics: Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Diosmin; Flavonoids; Hesperidin; Pharmaceutical Preparations; Solid Phase Microextraction; Ultraviolet Rays

2017
Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Administration, Topical; Animals; Chromatography, High Pressure Liquid; Cotton Fiber; Drug Delivery Systems; Hesperidin; Humans; Lipids; Nanocapsules; Nylons; Skin Absorption; Sus scrofa

2017
The effects of Nobiletin, Hesperetin, and Letrozole in a combination on the activity and expression of aromatase in breast cancer cells.
    Cellular and molecular biology (Noisy-le-Grand, France), 2017, Feb-28, Volume: 63, Issue:2

    Topics: Aromatase; Aromatase Inhibitors; Estradiol; Flavones; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hesperidin; Humans; Immunoassay; Letrozole; MCF-7 Cells; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; Triazoles

2017
Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study.
    Life sciences, 2017, Jun-01, Volume: 178

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Diabetes Mellitus; Drug Design; Gluconeogenesis; Hesperidin; Inhibitory Concentration 50; Liver; Molecular Docking Simulation; Rats

2017
The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration.
    Oncotarget, 2017, Mar-28, Volume: 8, Issue:13

    Topics: Animals; Apoptosis; Bone Regeneration; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Hesperidin; Humans; Male; Mesenchymal Stem Cells; Osteogenesis; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Tissue Engineering

2017
Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl
    Toxicology letters, 2017, May-15, Volume: 274

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Hesperidin; Inflammation; Janus Kinase 1; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; PPAR gamma; Random Allocation; RAW 264.7 Cells; Silymarin; STAT1 Transcription Factor

2017
Is Failure of Cocrystallization Actually a Failure? Eutectic Formation in Cocrystal Screening of Hesperetin.
    Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:8

    Topics: Animals; Antioxidants; Crystallization; Erythrocytes; Hemolysis; Hesperidin; Models, Molecular; Powder Diffraction; Protective Agents; Rats; Solubility; Thermodynamics; X-Ray Diffraction

2017
Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamous cell carcinoma in golden Syrian hamsters.
    Archives of physiology and biochemistry, 2017, Volume: 123, Issue:4

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cheek; Citrus; Cricetinae; Flavanones; Hesperidin; Immunoenzyme Techniques; Lipid Peroxidation; Male; Mesocricetus; Mouth Neoplasms

2017
Bacterial Biosensors for in Vivo Spatiotemporal Mapping of Root Secretion.
    Plant physiology, 2017, Volume: 174, Issue:3

    Topics: Biosensing Techniques; Colony Count, Microbial; Gene Expression Regulation, Plant; Hesperidin; Image Processing, Computer-Assisted; Luminescence; Metabolome; Nitrogen Fixation; Pisum sativum; Plant Exudates; Plant Root Nodulation; Plant Roots; Rhizobium leguminosarum; Rhizosphere; Root Nodules, Plant; Symbiosis; Time Factors; Vicia

2017
Hesperetin post-treatment prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating PI3K/Akt signaling pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 91

    Topics: Animals; Apoptosis; Cardiotonic Agents; Caspase 3; Cell Survival; Hesperidin; Hypoxia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction

2017
Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53- independent pathway in human lung cancer H522 cells.
    Journal of Asian natural products research, 2018, Volume: 20, Issue:6

    Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemoprevention; Gene Expression; Hesperidin; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial

2018
Protective effect of hesperetin against haloperidol-induced orofacial dyskinesia and catalepsy in rats.
    Nutritional neuroscience, 2018, Volume: 21, Issue:9

    Topics: Animals; Behavior, Animal; Brain; Catalepsy; Dopamine; Dyskinesia, Drug-Induced; Dyskinesias; Glutathione; Haloperidol; Hesperidin; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Serotonin; Superoxide Dismutase

2018
Design, Synthesis and Evaluation of Hesperetin Derivatives as Potential Multifunctional Anti-Alzheimer Agents.
    Molecules (Basel, Switzerland), 2017, Jun-26, Volume: 22, Issue:7

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Antioxidants; Catalytic Domain; Cell Line; Drug Design; GPI-Linked Proteins; Hesperidin; Humans; Hydrogen Peroxide; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; PC12 Cells; Protein Aggregates; Rats; Structure-Activity Relationship

2017
Immunomodulatory potential of hesperetin and chrysin through the cellular and humoral response.
    European journal of pharmacology, 2017, Oct-05, Volume: 812

    Topics: Animals; Cell Proliferation; Flavonoids; Hesperidin; Humans; Immunity, Cellular; Immunity, Humoral; Immunologic Factors; Intracellular Membranes; K562 Cells; Macrophages, Peritoneal; Male; Natural Killer T-Cells; Nitric Oxide; Permeability; Rats; Rats, Wistar; Spleen; T-Lymphocytes, Cytotoxic

2017
Urinary metabolite profiling of flavonoids in Chinese volunteers after consumption of orange juice by UFLC-Q-TOF-MS/MS.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017, Sep-01, Volume: 1061-1062

    Topics: Adult; China; Chromatography, High Pressure Liquid; Citrus sinensis; Female; Flavanones; Flavonoids; Fruit and Vegetable Juices; Hesperidin; Humans; Male; Tandem Mass Spectrometry; Young Adult

2017
Design, synthesis and biological evaluation of hesperetin derivatives as potent anti-inflammatory agent.
    Fitoterapia, 2017, Volume: 121

    Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Hesperidin; Interleukin-6; Liver; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide; RAW 264.7 Cells; Tumor Necrosis Factor-alpha

2017
Production of drug nanosuspensions: effect of drug physical properties on nanosizing efficiency.
    Drug development and industrial pharmacy, 2018, Volume: 44, Issue:2

    Topics: Calorimetry, Differential Scanning; Crystallization; Desiccation; Glyburide; Hesperidin; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Powder Diffraction; Quercetin; Resveratrol; Rutin; Stilbenes; Technology, Pharmaceutical

2018
Chitosan-based nano-formulation enhances the anticancer efficacy of hesperetin.
    International journal of biological macromolecules, 2018, Volume: 107, Issue:Pt B

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Drug Delivery Systems; Drug Liberation; Gene Expression Regulation, Neoplastic; Hesperidin; Humans; Nanoparticles; Particle Size; Powders; Spectroscopy, Fourier Transform Infrared; Static Electricity; X-Ray Diffraction

2018
Preventive effect of hesperidin modulates inflammatory responses and antioxidant status following acute myocardial infarction through the expression of PPAR‑γ and Bcl‑2 in model mice.
    Molecular medicine reports, 2018, Volume: 17, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; bcl-2-Associated X Protein; Cardiotonic Agents; Caspase 9; Chemokine CCL2; Creatine Kinase, MB Form; Drug Evaluation, Preclinical; Hesperidin; Intercellular Adhesion Molecule-1; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53

2018
Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97

    Topics: Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hesperidin; Hippocampus; Male; Malondialdehyde; Memory Disorders; Nanoparticles; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase

2018
Chemical constituents from the flowers of Satsuma mandarin and their free radical scavenging and
    Natural product research, 2019, Volume: 33, Issue:11

    Topics: Citrus; Drug Evaluation, Preclinical; Flavonoids; Flowers; Free Radical Scavengers; Glycoside Hydrolase Inhibitors; Hesperidin; Japan; Magnetic Resonance Spectroscopy; Molecular Structure; Phenols; Plants, Medicinal; Quercetin; Rutin

2019
Citrus bioflavonoid, hesperetin, as inhibitor of two thrombin-like snake venom serine proteases isolated from Crotalus simus.
    Toxicon : official journal of the International Society on Toxinology, 2018, Mar-01, Volume: 143

    Topics: Animals; Crotalid Venoms; Crotalus; Fibrinolysis; Hesperidin; Humans; Kinetics; Molecular Docking Simulation; Protein Conformation; Sequence Analysis, Protein; Serine Proteases; Tandem Mass Spectrometry

2018
    Natural product research, 2019, Volume: 33, Issue:16

    Topics: Antioxidants; Apiaceae; Cinnamates; Depsides; Hesperidin; Iran; Phenols; Plant Extracts; Polyphenols; Rosmarinic Acid

2019
The acute effects of citrus flavanones on the metabolism of glycogen and monosaccharides in the isolated perfused rat liver.
    Toxicology letters, 2018, Volume: 291

    Topics: Adenosine Diphosphate; Animals; Citrus; Energy Metabolism; Flavanones; Flavones; Fructose; Glucose; Glycogenolysis; Hesperidin; In Vitro Techniques; Liver; Liver Glycogen; Male; Monosaccharides; Oxygen Consumption; Perfusion; Rats; Rats, Wistar

2018
Magnetic molecularly imprinted polymer for the selective extraction of hesperetin from the dried pericarp of Citrus reticulata Blanco.
    Talanta, 2018, Jul-01, Volume: 184

    Topics: Citrus; Fruit; Hesperidin; Magnetite Nanoparticles; Molecular Imprinting; Molecular Structure; Particle Size; Polymers; Surface Properties

2018
Nanocrystals for improved dermal drug delivery.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018, Volume: 128

    Topics: Administration, Cutaneous; Biological Availability; Chemistry, Pharmaceutical; Drug Compounding; Drug Delivery Systems; Excipients; Hesperidin; Hydrogels; Nanoparticles; Organic Chemicals; Rutin; Skin Absorption; Solubility

2018
Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons.
    Archives of biochemistry and biophysics, 2018, 07-15, Volume: 650

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Enzyme Activation; Enzyme Inhibitors; Hesperidin; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Molecular; Neurons; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt

2018
The citrus flavonone hesperetin attenuates the nuclear translocation of aryl hydrocarbon receptor.
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2018, Volume: 210

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Active Transport, Cell Nucleus; Antineoplastic Agents, Phytogenic; Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Carcinogens, Environmental; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Dietary Supplements; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Hesperidin; Humans; MCF-7 Cells; Microscopy, Confocal; Neoplasm Proteins; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon

2018
Metabolism of Phenolic Compounds in LPS-stimulated Raw264.7 Cells Can Impact Their Anti-inflammatory efficacy: Indication of Hesperetin.
    Journal of agricultural and food chemistry, 2018, Jun-20, Volume: 66, Issue:24

    Topics: Animals; Anti-Inflammatory Agents; Hesperidin; Lipopolysaccharides; Macrophages; Mice; Phenols; RAW 264.7 Cells

2018
Effect of hesperetin derivatives on the development of selenite‑induced cataracts in rats.
    Molecular medicine reports, 2018, Volume: 18, Issue:1

    Topics: Animals; Ascorbic Acid; Cataract; Female; Glutathione; Hesperidin; Rats; Rats, Sprague-Dawley; Selenious Acid

2018
Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives.
    International immunopharmacology, 2018, Volume: 61

    Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred Strains; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Structure-Activity Relationship

2018
Hesperetin Mitigates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting Extracellular Matrix and Cell Apoptosis via the TGF-β1/Smad Pathway.
    Current molecular medicine, 2018, Volume: 18, Issue:1

    Topics: Animals; Apoptosis; Disease Models, Animal; Extracellular Matrix; Hesperidin; Interleukin-6; Liver Cirrhosis; Male; Mice; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

2018
High throughput screening of mitochondrial bioenergetics in human differentiated myotubes identifies novel enhancers of muscle performance in aged mice.
    Scientific reports, 2018, 06-20, Volume: 8, Issue:1

    Topics: Adenosine Triphosphate; Animals; Cell Differentiation; Energy Metabolism; Hesperidin; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Muscle Fibers, Skeletal; Muscle, Skeletal; Oxidative Stress

2018
In Silico Docking and In Vitro Approaches towards BACE1 and Cholinesterases Inhibitory Effect of Citrus Flavanones.
    Molecules (Basel, Switzerland), 2018, Jun-22, Volume: 23, Issue:7

    Topics: Acetylcholinesterase; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Citrus; Enzyme Assays; Flavanones; GPI-Linked Proteins; Hesperidin; Humans; Kinetics; Molecular Docking Simulation; Neuroprotective Agents; Nootropic Agents; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Thermodynamics

2018
Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2018, Volume: 69

    Topics: Animals; Anticonvulsants; Antioxidants; Autistic Disorder; Birth Weight; Brain Chemistry; Cytokines; Female; Hesperidin; Inflammation; Interpersonal Relations; Motor Activity; Nanoparticles; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Social Behavior; Valproic Acid

2018
Synthesis of hesperetin-loaded PLGA nanoparticles by two different experimental design methods and biological evaluation of optimized nanoparticles.
    Nanotechnology, 2018, Sep-28, Volume: 29, Issue:39

    Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Cell Line; Cell Survival; Chemistry, Pharmaceutical; Escherichia coli; Hesperidin; Lactic Acid; Mice; Microbial Sensitivity Tests; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Regression Analysis; Staphylococcus aureus

2018
Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin-induced focal demyelination model of rat optic chiasm.
    Life sciences, 2018, Aug-15, Volume: 207

    Topics: Animals; Antioxidants; Citrus; Demyelinating Diseases; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Lysophosphatidylcholines; Male; Multiple Sclerosis; Myelin Sheath; Neuroglia; Optic Chiasm; Rats; Rats, Wistar

2018
Solid Dispersion of Hesperetin Co-crystals Synergistically Attenuates Hepatic Toxicity of Carbon Tetrachloride Oxidative Stress in Rats.
    Current drug delivery, 2018, Volume: 15, Issue:10

    Topics: Animals; Biological Availability; Carbon Tetrachloride; Crystallization; Hesperidin; Liver; Oxidative Stress; Particle Size; Rats; Solubility; Surface Properties

2018
Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy.
    Journal of medicinal food, 2018, Volume: 21, Issue:12

    Topics: Administration, Oral; Animals; Anticonvulsants; Citrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fruit; Hesperidin; Kainic Acid; Male; Mice; Phytotherapy

2018
Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis.
    Life sciences, 2018, Oct-01, Volume: 210

    Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cells, Cultured; Citrus; Diabetes Mellitus, Experimental; Flavonoids; Hesperidin; Inflammation; Male; Oxidative Stress; Rats; Rats, Wistar; Testicular Diseases

2018
Insecticidal effects of the Olea europaea subsp. laperrinei extracts on the flour Pyralid Ephestia kuehniella.
    Cellular and molecular biology (Noisy-le-Grand, France), 2018, Aug-30, Volume: 64, Issue:11

    Topics: Animals; Chromatography, High Pressure Liquid; Female; Hesperidin; Insecticides; Iridoid Glucosides; Iridoids; Larva; Moths; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Quercetin

2018
Effect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid-induced experimental colitis model.
    Cellular and molecular biology (Noisy-le-Grand, France), 2018, Aug-30, Volume: 64, Issue:11

    Topics: Animals; Antioxidants; Colitis; Enzyme-Linked Immunosorbent Assay; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Lipid Peroxidation; Male; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha

2018
Pharmacokinetic study of the prokinetic ABCs liquiritigenin, naringenin and hesperitin following the oral administration of Si-Ni-San decoction to functional dyspepsia patients.
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:6

    Topics: Administration, Oral; Adult; Chromatography, Liquid; Drugs, Chinese Herbal; Dyspepsia; Female; Flavanones; Gastrointestinal Motility; Hesperidin; Humans; Male; Middle Aged; Sulfamethoxazole

2019
Inhibition of Atherosclerotic Plaque Development by Oral Administration of α-Glucosyl Hesperidin and Water-Dispersible Hesperetin in Apolipoprotein E Knockout Mice.
    Journal of the American College of Nutrition, 2019, Volume: 38, Issue:1

    Topics: Administration, Oral; Animals; Antioxidants; Apolipoproteins E; Cholesterol; Diet, High-Fat; Glucosides; Hesperidin; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic

2019
Hesperetin mitigates acrolein-induced apoptosis in lung cells in vitro and in vivo.
    Redox report : communications in free radical research, 2018, Volume: 23, Issue:1

    Topics: Acrolein; Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Hesperidin; Mice; Oxidative Stress; Reactive Oxygen Species

2018
Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro.
    Molecular reproduction and development, 2019, Volume: 86, Issue:1

    Topics: Animals; Blastocyst; Cellular Senescence; Embryonic Development; Hesperidin; Oocytes; Oxidative Stress; Reactive Oxygen Species; Swine

2019
Immunohistochemical examination of anti-inflammatory and anti-apoptotic effects of hesperetin on trinitrobenzene sulfonic acid induced colitis in rats.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2019, Volume: 94, Issue:3

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Colitis; Gene Expression Regulation; Hesperidin; Immunohistochemistry; Inflammation; Leukocyte Common Antigens; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha

2019
Suppression of Taxanes Cytotoxicity by Citrus Flavonoid Hesperetin in PPC-1 Human Prostate Cancer Cells.
    Anticancer research, 2018, Volume: 38, Issue:11

    Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dietary Supplements; Docetaxel; Drug Antagonism; Hesperidin; Humans; Male; Prostatic Neoplasms; Taxoids

2018
Sulfation of hesperetin, naringenin and apigenin by the human cytosolic sulfotransferases: a comprehensive analysis.
    Natural product research, 2020, Volume: 34, Issue:6

    Topics: Apigenin; Cell Line, Tumor; Cytosol; Flavanones; Hesperidin; Humans; Intestinal Mucosa; Kidney; Liver; Lung; Metabolic Networks and Pathways; Sulfates; Sulfotransferases

2020
Optimization of Regioselective α-Glucosylation of Hesperetin Catalyzed by Cyclodextrin Glucanotransferase.
    Molecules (Basel, Switzerland), 2018, Nov-05, Volume: 23, Issue:11

    Topics: Catalysis; Chromatography, High Pressure Liquid; Glucosyltransferases; Glycosylation; Hesperidin; Mass Spectrometry; Molecular Structure

2018
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
    Journal of cellular physiology, 2019, Volume: 234, Issue:7

    Topics: Animals; Cell Proliferation; Gene Expression Regulation; Genes, fos; Hesperidin; Humans; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinases; Molecular Structure; NF-kappa B; NFATC Transcription Factors; Osteogenesis; Osteoporosis; RANK Ligand; RAW 264.7 Cells

2019
Nanocrystalline solid dispersions (NSD) of hesperetin (HRN) for prevention of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in Sprague-Dawley (SD) rats.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Feb-01, Volume: 128

    Topics: Animals; Anthracenes; Female; Hesperidin; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Nanoparticles; Piperidines; Random Allocation; Rats; Rats, Sprague-Dawley

2019
The citrus flavanone hesperetin preferentially inhibits slow-inactivating currents of a long QT syndrome type 3 syndrome Na
    British journal of pharmacology, 2019, Volume: 176, Issue:8

    Topics: Animals; Aorta, Abdominal; Cardiac Conduction System Disease; Cardiotonic Agents; Citrus; Heart; HEK293 Cells; Hesperidin; Humans; Long QT Syndrome; Male; Models, Molecular; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Rats, Wistar; Vasodilator Agents

2019
Modulating effect of hesperetin on the molecular expression pattern of apoptotic and cell proliferative markers in 7,12-dimethylbenz(a)anthracene-induced oral carcinogenesis.
    Archives of physiology and biochemistry, 2020, Volume: 126, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Biomarkers, Tumor; Carcinogens; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hesperidin; Male; Mesocricetus; Mouth Neoplasms; Protective Agents

2020
Comparative evaluation of hesperetin loaded nanoparticles for anticancer activity against C6 glioma cancer cells.
    Artificial cells, nanomedicine, and biotechnology, 2019, Volume: 47, Issue:1

    Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Carriers; Glioma; Glutathione; Hesperidin; Humans; Malondialdehyde; Nanoparticles; Oxidative Stress; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Superoxide Dismutase

2019
Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model.
    Molecular neurobiology, 2019, Volume: 56, Issue:9

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Astrocytes; Biomarkers; Cell Line; Cognitive Dysfunction; Disease Models, Animal; Hesperidin; Hippocampus; Male; Memory; Memory Disorders; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Neuroprotection; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Signal Transduction; Synapses; Toll-Like Receptor 4

2019
Hesperetin derivative-12 (HDND-12) regulates macrophage polarization by modulating JAK2/STAT3 signaling pathway.
    Chinese journal of natural medicines, 2019, Volume: 17, Issue:2

    Topics: Animals; Cytokines; Enzyme Inhibitors; Gene Expression Regulation; Hesperidin; Inflammation; Janus Kinase 2; Macrophages; Medicine, Chinese Traditional; Mice; Molecular Structure; Phosphorylation; RAW 264.7 Cells; Signal Transduction; STAT3 Transcription Factor

2019
Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury by targeting MD2.
    European journal of pharmacology, 2019, Jun-05, Volume: 852

    Topics: Acute Lung Injury; Animals; Cytoprotection; Gene Expression Regulation; Hesperidin; Humans; Lipopolysaccharides; Lung; Lymphocyte Antigen 96; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Targeted Therapy; Protein Conformation; RAW 264.7 Cells; Toll-Like Receptor 4

2019
Hesperetin and Hesperidin Improved β-Carotene Incorporation Efficiency, Intestinal Cell Uptake, and Retinoid Concentrations in Tissues.
    Journal of agricultural and food chemistry, 2019, Mar-27, Volume: 67, Issue:12

    Topics: Animals; beta Carotene; Biological Availability; Biological Transport; Caco-2 Cells; Citrus; Hesperidin; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Retinoids

2019
Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 111

    Topics: Animals; Carboxylic Ester Hydrolases; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glutamate-Cysteine Ligase; Glycation End Products, Advanced; Hesperidin; Inflammation; Kidney; Lactoylglutathione Lyase; Male; NF-E2-Related Factor 2; Protective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; Up-Regulation

2019
Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling.
    Nutrients, 2019, Mar-17, Volume: 11, Issue:3

    Topics: Animals; Apoptosis; Citrus; Hesperidin; Hippocampus; Lipopolysaccharides; Male; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Neuritis; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Signal Transduction; Toll-Like Receptor 4

2019
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
    Diabetes, 2019, Volume: 68, Issue:6

    Topics: Animals; Bone Marrow Cells; Cell- and Tissue-Based Therapy; Diabetes Mellitus, Type 2; Disease Models, Animal; Endoribonucleases; Gene Knock-In Techniques; Gene Transfer Techniques; Hesperidin; Lactoylglutathione Lyase; Mice; Neovascularization, Physiologic; Protein Serine-Threonine Kinases; Pyruvaldehyde; Resveratrol; Skin; Stem Cells; Wound Healing; Wounds and Injuries

2019
Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 113

    Topics: A549 Cells; Adenocarcinoma of Lung; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Disease Progression; Glucuronosyltransferase; Hesperidin; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Platinum Compounds; Reactive Oxygen Species; Xenograft Model Antitumor Assays

2019
Targeted delivery of hesperetin to cartilage attenuates osteoarthritis by bimodal imaging with Gd
    Biomaterials, 2019, Volume: 205

    Topics: Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Down-Regulation; Drug Delivery Systems; Gadolinium; Hesperidin; Inflammation; Interleukin-1beta; Male; Mice, Inbred C57BL; Nanoparticles; NF-kappa B; Osteoarthritis; Peptides; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Toll-Like Receptor 2

2019
The Scalability of Wet Ball Milling for The Production of Nanosuspensions.
    Pharmaceutical nanotechnology, 2019, Volume: 7, Issue:2

    Topics: Curcumin; Drug Compounding; Excipients; Hesperidin; Nanoparticles; Poloxamer; Sodium Cholate; Suspensions; Technology, Pharmaceutical

2019
Cortico-hippocampal memory enhancing activity of hesperetin on scopolamine-induced amnesia in mice: role of antioxidant defense system, cholinergic neurotransmission and expression of BDNF.
    Metabolic brain disease, 2019, Volume: 34, Issue:4

    Topics: Acetylcholinesterase; Amnesia; Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cholinergic Neurons; Hesperidin; Hippocampus; Maze Learning; Memory; Mice; Neuroprotective Agents; Oxidative Stress; Scopolamine; Synaptic Transmission

2019
Combined administration of naringenin and hesperetin with optimal ratio maximizes the anti-cancer effect in human pancreatic cancer via down regulation of FAK and p38 signaling pathway.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 58

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Citrus; Down-Regulation; Flavanones; Focal Adhesion Kinase 1; Hesperidin; Humans; MAP Kinase Signaling System; Mice, Inbred BALB C; Pancreatic Neoplasms; Phosphorylation; Xenograft Model Antitumor Assays

2019
A hesperetin derivative plays a role in immunoregulatory effect on human macrophages.
    Cellular and molecular biology (Noisy-le-Grand, France), 2019, Apr-30, Volume: 65, Issue:4

    Topics: bcl-X Protein; Cell Proliferation; Cell Survival; Hesperidin; Humans; Immunologic Factors; Interleukin-1beta; Interleukin-6; Macrophages; Nitric Oxide; Phagocytosis; THP-1 Cells

2019
Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells.
    Journal of physiology and biochemistry, 2019, Volume: 75, Issue:2

    Topics: AMP-Activated Protein Kinases; Carbazoles; Hep G2 Cells; Hesperidin; Humans; Phosphorylation; Resveratrol; Signal Transduction; Sirtuin 1

2019
Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis.
    Chemico-biological interactions, 2019, Aug-01, Volume: 308

    Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Cell Line; Cell Survival; Cisplatin; Creatinine; Hesperidin; Humans; Inflammation; Kidney; Mice; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction

2019
Preparation of restricted access molecularly imprinted polymers based fiber for selective solid-phase microextraction of hesperetin and its metabolites in vivo.
    Talanta, 2019, Sep-01, Volume: 202

    Topics: Hesperidin; Molecular Imprinting; Polymers; Solid Phase Microextraction

2019
Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation.
    Nutrition and cancer, 2020, Volume: 72, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; G2 Phase Cell Cycle Checkpoints; Glioblastoma; Hesperidin; Humans; p38 Mitogen-Activated Protein Kinases

2020
High level production of flavonoid rhamnosides by metagenome-derived Glycosyltransferase C in Escherichia coli utilizing dextrins of starch as a single carbon source.
    Metabolic engineering, 2019, Volume: 55

    Topics: Bacterial Proteins; Dextrins; Escherichia coli; Glycosyltransferases; Hesperidin; Metagenome; Microorganisms, Genetically-Modified

2019
Synthesis of Daidzein Glycosides, α-Tocopherol Glycosides, Hesperetin Glycosides by Bioconversion and Their Potential for Anti-Allergic Functional-Foods and Cosmetics.
    Molecules (Basel, Switzerland), 2019, Aug-16, Volume: 24, Issue:16

    Topics: alpha-Tocopherol; Animals; Anti-Allergic Agents; Biocatalysis; Cell Culture Techniques; Cosmetics; Functional Food; Glycosides; Glycosylation; Hesperidin; Humans; Isoflavones; Male; Mast Cells; Monophenol Monooxygenase; Nicotiana; Plant Cells; Primary Cell Culture; Rats; Rats, Wistar; Solubility

2019
Enzyme-assisted biotransformation increases hesperetin content in citrus juice by-products.
    Food research international (Ottawa, Ont.), 2019, Volume: 124

    Topics: Antioxidants; Biodegradation, Environmental; Carboxylic Ester Hydrolases; Citrus; Glycoside Hydrolases; Hesperidin; Hydrolysis; Industrial Waste; Phenols

2019
Hesperetin derivative attenuates CCl
    International immunopharmacology, 2019, Volume: 76

    Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytokines; Hepatic Stellate Cells; Hesperidin; Humans; Liver Cirrhosis; Macrophages; Male; Mice, Inbred C57BL; Protective Agents; Transforming Growth Factor beta1; Zinc Finger Protein GLI1

2019
Boronic-targeted albumin-shell oily-core nanocapsules for synergistic aromatase inhibitor/herbal breast cancer therapy.
    Materials science & engineering. C, Materials for biological applications, 2019, Volume: 105

    Topics: Albumins; Androstadienes; Antineoplastic Agents, Phytogenic; Aromatase Inhibitors; Boron; Breast Neoplasms; Female; Hesperidin; Humans; MCF-7 Cells; Nanocapsules; Phospholipids

2019
Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-
    Molecules (Basel, Switzerland), 2019, Oct-11, Volume: 24, Issue:20

    Topics: Animals; Celecoxib; Cyclooxygenase 2; Gene Expression Regulation; Hesperidin; Humans; Hydrophobic and Hydrophilic Interactions; Indomethacin; Inflammation; Interleukin-1beta; Interleukin-6; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Signal Transduction; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2019
Comprehensive bioinformatics study reveals targets and molecular mechanism of hesperetin in overcoming breast cancer chemoresistance.
    Molecular diversity, 2020, Volume: 24, Issue:4

    Topics: Breast Neoplasms; Cell Line, Tumor; Computational Biology; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Ontology; Hesperidin; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Signal Transduction

2020
Protective role of hesperetin against posttranslational oxidation of tryptophan residue of human γD-crystallin: A molecular level study.
    Archives of biochemistry and biophysics, 2020, 01-15, Volume: 679

    Topics: gamma-Crystallins; Hesperidin; Humans; Models, Molecular; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Tryptophan

2020
The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of
    Molecules (Basel, Switzerland), 2019, Nov-13, Volume: 24, Issue:22

    Topics: Antioxidants; Citrus; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Hesperidin; Microbial Viability; Plant Extracts; Reactive Oxygen Species; Saccharomyces cerevisiae

2019
Urinary flavanone concentrations as biomarkers of dietary flavanone intakes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
    The British journal of nutrition, 2020, 03-28, Volume: 123, Issue:6

    Topics: Biomarkers; Citrus sinensis; Diet; Europe; Female; Flavanones; Hesperidin; Humans; Male; Middle Aged; Nutrition Assessment; Nutrition Surveys

2020
Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4-MyD88-NF-κB signaling pathway.
    Archives of pharmacal research, 2019, Volume: 42, Issue:12

    Topics: Acute Lung Injury; Animals; Dose-Response Relationship, Drug; Hesperidin; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2019
Effect of hesperetin on systemic inflammation and hepatic injury after blunt chest trauma in rats.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2020, Volume: 95, Issue:4

    Topics: Animals; Apoptosis; Hesperidin; Inflammation; Liver; Liver Diseases; Rats; Wounds and Injuries

2020
Hesperetin as an adjuvant augments protective anti-tumour immunity responses in B16F10 melanoma by stimulating cytotoxic CD8
    Scandinavian journal of immunology, 2020, Volume: 91, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Cancer Vaccines; CD8-Positive T-Lymphocytes; Female; Hesperidin; Melanoma, Experimental; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Skin Neoplasms

2020
Hesperetin ameliorates DSS-induced colitis by maintaining the epithelial barrier via blocking RIPK3/MLKL necroptosis signaling.
    European journal of pharmacology, 2020, Apr-15, Volume: 873

    Topics: Animals; Caco-2 Cells; Cell Membrane Permeability; Colitis; Cytokines; Dextran Sulfate; Epithelium; Hesperidin; Humans; Mice; Mice, Inbred C57BL; Necroptosis; Protein Kinases; RAW 264.7 Cells; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction

2020
Neuro-protective effects of nano-formulated hesperetin in a traumatic brain injury model of
    Drug and chemical toxicology, 2022, Volume: 45, Issue:2

    Topics: Animals; Brain Injuries, Traumatic; Hesperidin; Humans; Spectroscopy, Fourier Transform Infrared; Zebrafish

2022
Hesperetin reverses P‑glycoprotein‑mediated cisplatin resistance in DDP‑resistant human lung cancer cells via modulation of the nuclear factor‑κB signaling pathway.
    International journal of molecular medicine, 2020, Volume: 45, Issue:4

    Topics: A549 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B; Cisplatin; Drug Resistance, Neoplasm; Hesperidin; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Proteins; Signal Transduction; Transcription Factor RelA

2020
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
    Food & function, 2020, Mar-26, Volume: 11, Issue:3

    Topics: Aged; Animals; Cells, Cultured; Chondrocytes; Female; Hesperidin; Humans; Interleukin-1beta; Male; Medial Collateral Ligament, Knee; Mice; Mice, Inbred C57BL; Middle Aged; NF-E2-Related Factor 2; NF-kappa B; Osteoarthritis; Protective Agents; Signal Transduction

2020
The Citrus Flavanone Hesperetin Induces Apoptosis in CTCL Cells
    Anti-cancer agents in medicinal chemistry, 2020, Volume: 20, Issue:12

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Citrus; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hesperidin; Humans; Molecular Structure; NF-kappa B; Receptor, Notch1; Signal Transduction; STAT3 Transcription Factor; Structure-Activity Relationship; Tumor Cells, Cultured

2020
Insights into Interactions of Flavanones with Target Human Respiratory Syncytial Virus M
    International journal of molecular sciences, 2020, Mar-24, Volume: 21, Issue:6

    Topics: Antiviral Agents; Binding Sites; Hesperidin; Molecular Docking Simulation; Protein Binding; Viral Proteins

2020
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression.
    International immunopharmacology, 2020, Volume: 83

    Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Heme Oxygenase-1; Hepatocytes; Hesperidin; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Oxidative Stress; Transaminases; Up-Regulation

2020
Hesperetin alleviated glucocorticoid-induced inhibition of osteogenic differentiation of BMSCs through regulating the ERK signaling pathway.
    Medical molecular morphology, 2021, Volume: 54, Issue:1

    Topics: Butadienes; Cell Differentiation; Dexamethasone; Extracellular Signal-Regulated MAP Kinases; Glucocorticoids; Hesperidin; Humans; MAP Kinase Signaling System; Mesenchymal Stem Cells; Nitriles; Osteogenesis; Osteoporosis; Primary Cell Culture

2021
Biochemical and genotoxic biomarkers and cell cycle assessment in the zebrafish liver (ZF-L) cell line exposed to the novel metal-insecticide magnesium-hespiridin complex.
    Chemosphere, 2020, Volume: 250

    Topics: Animals; Antioxidants; Cell Cycle; Cell Line; DNA Damage; Dose-Response Relationship, Drug; Ecotoxicology; Environmental Biomarkers; Glutathione; Hesperidin; Insecticides; Lipid Peroxidation; Liver; Magnesium; Mutagenicity Tests; Oxidative Stress; Reactive Oxygen Species; Water Pollutants, Chemical; Zebrafish

2020
Hesperetin inhibit EMT in TGF-β treated podocyte by regulation of mTOR pathway.
    Biochemical and biophysical research communications, 2020, 07-12, Volume: 528, Issue:1

    Topics: Cell Death; Epithelial-Mesenchymal Transition; Hesperidin; Humans; Podocytes; Signal Transduction; Smad Proteins; TOR Serine-Threonine Kinases; Transforming Growth Factor beta

2020
Cytotoxic and Antimetastatic Activity of Hesperetin and Doxorubicin Combination Toward Her2 Expressing Breast Cancer Cells.
    Asian Pacific journal of cancer prevention : APJCP, 2020, May-01, Volume: 21, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Movement; Cell Proliferation; Doxorubicin; Female; Hesperidin; Humans; Receptor, ErbB-2; Tumor Cells, Cultured

2020
Double-Interface Binding of Two Bioactive Compounds with Cage-Like Ferritin.
    Journal of agricultural and food chemistry, 2020, Jul-22, Volume: 68, Issue:29

    Topics: Ferritins; Hesperidin; Hydrogen-Ion Concentration

2020
The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na
    Biomolecules, 2020, 06-24, Volume: 10, Issue:6

    Topics: Anti-Arrhythmia Agents; Cardiac Conduction System Disease; Cells, Cultured; Citrus; Dose-Response Relationship, Drug; HEK293 Cells; Hesperidin; Humans; Long QT Syndrome; Mutation; NAV1.5 Voltage-Gated Sodium Channel

2020
Comparative Pharmacokinetic Study of Hesperetin after Oral Administration in Normal and Hyperuricemia Rats by UPLC-MS/MS.
    Current reviews in clinical and experimental pharmacology, 2021, Volume: 16, Issue:2

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Hesperidin; Hyperuricemia; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2021
Mechanisms of Neuroprotective Action of Hesperetin and Carnosine in Focal Ischemia of the Brain in Rats.
    Bulletin of experimental biology and medicine, 2020, Volume: 169, Issue:2

    Topics: Animals; Brain; Brain Ischemia; Carnosine; Hesperidin; Male; Neuroprotective Agents; Rats; Rats, Wistar

2020
Hesperetin ameliorates lipopolysaccharide-induced acute lung injury via the miR-410/SOX18 axis.
    Journal of biochemical and molecular toxicology, 2020, Volume: 34, Issue:12

    Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Enzyme-Linked Immunosorbent Assay; Hesperidin; Inflammation Mediators; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; MicroRNAs; SOXF Transcription Factors

2020
Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes.
    Toxicology and applied pharmacology, 2020, 10-01, Volume: 404

    Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Regulation; Gene Silencing; Heat-Shock Proteins; Hepatocytes; Hesperidin; Male; Palmitates; Rats; Rats, Wistar; RNA, Small Interfering; Signal Transduction

2020
Neuroinflammation and Neurodegeneration: The Promising Protective Role of the Citrus Flavanone Hesperetin.
    Nutrients, 2020, Aug-05, Volume: 12, Issue:8

    Topics: Anti-Inflammatory Agents; Antioxidants; Beverages; Citrus; Diet; Flavanones; Hesperidin; Humans; Inflammation; Neurodegenerative Diseases

2020
Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model.
    Brain research bulletin, 2020, Volume: 164

    Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Male; Optic Chiasm; Rats; Rats, Wistar; Recovery of Function; Remyelination; Visual Cortex; Visual Pathways

2020
Targeting the Nrf2/ARE Signalling Pathway to Mitigate Isoproterenol-Induced Cardiac Hypertrophy: Plausible Role of Hesperetin in Redox Homeostasis.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Animals; Antioxidants; Biomarkers; Cardiomegaly; Cell Line; Cell Nucleus; Cytoprotection; Gene Expression Regulation; Hesperidin; Homeostasis; Isoproterenol; Male; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Protein Transport; Rats, Wistar; RNA, Messenger; Signal Transduction; Superoxides

2020
Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway.
    International immunopharmacology, 2020, Volume: 89, Issue:Pt B

    Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Activation; Galactosamine; HEK293 Cells; Hesperidin; Humans; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Protein Processing, Post-Translational; RAW 264.7 Cells; Signal Transduction; Sirtuin 1; Transcription Factor RelA

2020
Hesperetin targets the hydrophobic pocket of the nucleoprotein/phosphoprotein binding site of human respiratory syncytial virus.
    Journal of biomolecular structure & dynamics, 2022, Volume: 40, Issue:5

    Topics: Binding Sites; Child; Hesperidin; Humans; Molecular Docking Simulation; Nucleoproteins; Phosphoproteins; Protein Binding; Respiratory Syncytial Virus, Human

2022
Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier.
    Experimental eye research, 2021, Volume: 202

    Topics: Administration, Ophthalmic; Animals; Biological Availability; Cornea; Corneal Ulcer; Drug Carriers; Drug Delivery Systems; Eye Infections, Bacterial; Glycyrrhizic Acid; Hesperidin; Micelles; Microscopy, Electron, Transmission; Nanoparticles; Ophthalmic Solutions; Particle Size; Pharmaceutical Preparations; Rabbits; Staphylococcal Infections; Surface Properties

2021
Estimated dietary polyphenol intake and major food sources of the Brazilian population.
    The British journal of nutrition, 2021, 08-14, Volume: 126, Issue:3

    Topics: Beverages; Brazil; Chlorogenic Acid; Cross-Sectional Studies; Diet; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Polyphenols

2021
Urinary Biomarkers for Orange Juice Consumption.
    Molecular nutrition & food research, 2021, Volume: 65, Issue:2

    Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Citrus sinensis; Female; Flavanones; Fruit and Vegetable Juices; Hesperidin; Humans; Limit of Detection; Male; Phloretin; Proline; Reproducibility of Results; Synephrine; Tandem Mass Spectrometry; Urinalysis; Young Adult

2021
Biological evaluation of 7-O-amide hesperetin derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
    Chemico-biological interactions, 2021, Jan-25, Volume: 334

    Topics: Acetylcholinesterase; Alzheimer Disease; Amides; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cholinesterase Inhibitors; Hesperidin; Inflammation; Ligands; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats

2021
Short-Term Intake of Hesperetin-7-
    Journal of agricultural and food chemistry, 2021, Feb-10, Volume: 69, Issue:5

    Topics: Animals; Bacteria; Citric Acid Cycle; Fatty Acids, Volatile; Feces; Female; Gastrointestinal Microbiome; Hesperidin; Homeostasis; Humans; Magnetic Resonance Spectroscopy; Male; Metabolome; Mice; Mice, Inbred C57BL

2021
Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer's disease.
    Drug delivery and translational research, 2021, Volume: 11, Issue:2

    Topics: Alzheimer Disease; Hesperidin; Humans; Nanoparticles; Solubility

2021
Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice.
    European journal of medicinal chemistry, 2021, Mar-05, Volume: 213

    Topics: Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Hesperidin; Inflammation; Liver; Mice; Mice, Inbred C57BL; Molecular Structure; Nitric Oxide; RAW 264.7 Cells; Reactive Oxygen Species; Structure-Activity Relationship; Triazoles

2021
Cinnamaldehyde and hesperetin attenuate TNBS-induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway.
    Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:5

    Topics: Acrolein; Animals; Colitis, Ulcerative; Hesperidin; Janus Kinase 2; Male; Rats; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Trinitrobenzenesulfonic Acid

2021
Nanoemulsion for Improving the Oral Bioavailability of Hesperetin: Formulation Optimization and Absorption Mechanism.
    Journal of pharmaceutical sciences, 2021, Volume: 110, Issue:6

    Topics: Administration, Oral; Animals; Biological Availability; Emulsions; Hesperidin; Intestinal Absorption; Rats; Rats, Sprague-Dawley

2021
In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungunya virus proteases.
    PloS one, 2021, Volume: 16, Issue:3

    Topics: Animals; Chikungunya virus; Chlorocebus aethiops; Citrus; Hesperidin; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Peptide Hydrolases; Plant Extracts; Protein Conformation; Vero Cells; Viral Proteins; Zika Virus

2021
Inhibition of histone acetyltransferase by naringenin and hesperetin suppresses Txnip expression and protects pancreatic β cells in diabetic mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Jul-15, Volume: 88

    Topics: Acetylation; Animals; Carrier Proteins; Citrus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Flavanones; Hesperidin; Histone Acetyltransferases; Histones; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Rats; Thioredoxins

2021
Hesperetin promotes DOT1L degradation and reduces histone H3K79 methylation to inhibit gastric cancer metastasis.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 84

    Topics: Animals; Hesperidin; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Mice, Nude; Stomach Neoplasms

2021
Evaluation of hesperetin-loaded on multiple wall carbon nanotubes on cerebral ischemia/reperfusion injury in rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 138

    Topics: Animals; Brain Ischemia; Drug Evaluation, Preclinical; Hesperidin; Male; Nanotubes, Carbon; Rats; Rats, Wistar; Reperfusion Injury; Spectroscopy, Fourier Transform Infrared

2021
Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system.
    Toxicology and applied pharmacology, 2021, 05-15, Volume: 419

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Availability; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diterpenes, Kaurane; Drug Carriers; Drug Compounding; Drug Liberation; Female; Hesperidin; Humans; Membrane Potential, Mitochondrial; Mice; Micelles; Nanoparticles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Solubility; Tissue Distribution; Tumor Burden

2021
Targeting FGL2, a molecular drug target for glioblastoma, with natural compounds through virtual screening method.
    Future medicinal chemistry, 2021, Volume: 13, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; Betacyanins; Cell Proliferation; Computer Simulation; Diterpenes; Drug Screening Assays, Antitumor; Fibrinogen; Gene Expression Regulation; Glioblastoma; Hesperidin; Humans; Molecular Targeted Therapy; Protein Binding

2021
Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 139

    Topics: Animals; Antioxidants; Apoptosis; Dose-Response Relationship, Drug; Electrocardiography; Heart Function Tests; Hesperidin; Inflammation; Male; Mice; Myocardial Ischemia; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Sirtuin 1; Vasodilator Agents; Verapamil

2021
Hindering the Synchronization Between miR-486-5p and H19 lncRNA by Hesperetin Halts Breast Cancer Aggressiveness Through Tuning ICAM-1.
    Anti-cancer agents in medicinal chemistry, 2022, Volume: 22, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Hesperidin; Humans; Intercellular Adhesion Molecule-1; MicroRNAs; Middle Aged; RNA, Long Noncoding; Tumor Cells, Cultured

2022
Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease.
    Chemico-biological interactions, 2021, Jun-01, Volume: 342

    Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Discovery; Hesperidin; Ligands; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Neuroprotective Agents; Nitric Oxide; Protein Binding; Rats; Transcription Factor RelA; Triazoles

2021
Hesperetin as an inhibitor of the snake venom serine protease from Bothrops jararaca.
    Toxicon : official journal of the International Society on Toxinology, 2021, Jul-30, Volume: 198

    Topics: Animals; Bothrops; Brazil; Chromatography, Liquid; Crotalid Venoms; Hesperidin; Serine Proteases; Tandem Mass Spectrometry

2021
Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study.
    Archives of microbiology, 2021, Volume: 203, Issue:6

    Topics: Angiotensin-Converting Enzyme 2; Animals; Bees; Caffeic Acids; COVID-19 Drug Treatment; Flavanones; Flavonoids; Hesperidin; Humans; Luteolin; Molecular Docking Simulation; Phenylethyl Alcohol; Plant Extracts; Propolis; Quercetin; Rutin

2021
Hesperetin ameliorates hepatic oxidative stress and inflammation
    Food & function, 2021, May-11, Volume: 12, Issue:9

    Topics: Animals; Antioxidant Response Elements; Diet, High-Fat; Hep G2 Cells; Hepatocytes; Hesperidin; Humans; Interleukin-6; Lipid Metabolism; Liver; Liver Cirrhosis; Male; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Transcription Factor RelA; Transcriptional Activation; Tumor Necrosis Factor-alpha

2021
Hesperetin regulates transforming growth factor-β1/Smads pathway to suppress epithelial-mesenchymal transition -mediated invasion and migration in cervical cancer cell.
    Anti-cancer drugs, 2021, 10-01, Volume: 32, Issue:9

    Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; HeLa Cells; Hesperidin; Humans; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Uterine Cervical Neoplasms

2021
Hesperetin rescues emotional memory and synaptic plasticity deficit in aged rats.
    Behavioral neuroscience, 2021, Volume: 135, Issue:6

    Topics: Animals; Hesperidin; Hippocampus; Long-Term Potentiation; Neuronal Plasticity; Rats

2021
Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner.
    Journal of physiology and biochemistry, 2021, Volume: 77, Issue:3

    Topics: AMP-Activated Protein Kinase Kinases; Atherosclerosis; Cholesterol; Foam Cells; Hesperidin; Humans; Liver X Receptors; Protein Kinases; THP-1 Cells

2021
Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression.
    Journal of chemical neuroanatomy, 2021, Volume: 117

    Topics: Adrenergic Uptake Inhibitors; Animals; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Electroconvulsive Therapy; Hesperidin; Hippocampus; Male; Maze Learning; Memory Disorders; Oxidative Stress; Rats; Rats, Wistar; Reserpine

2021
Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway.
    Metabolic brain disease, 2021, Volume: 36, Issue:7

    Topics: Animals; Anxiety; Depression; Diabetes Mellitus, Experimental; Glycogen Synthase Kinase 3 beta; Hesperidin; NF-E2-Related Factor 2; Oxidative Stress; Rats

2021
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection.
    Nutrients, 2021, Aug-16, Volume: 13, Issue:8

    Topics: Angiotensin-Converting Enzyme 2; Animals; Cell Line, Tumor; Chlorocebus aethiops; Coronavirus Papain-Like Proteases; COVID-19; COVID-19 Drug Treatment; Hesperidin; Humans; Molecular Docking Simulation; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Vero Cells

2021
Microbial Phosphorylation Product of Hesperetin by
    Journal of agricultural and food chemistry, 2021, Sep-08, Volume: 69, Issue:35

    Topics: Animals; Bacillus subtilis; Biological Availability; Caco-2 Cells; Hesperidin; Humans; Phosphorylation; Rats

2021
Screening and heterologous expression of flavone synthase and flavonol synthase to catalyze hesperetin to diosmetin.
    Biotechnology letters, 2021, Volume: 43, Issue:11

    Topics: Angelica archangelica; Camellia; Flavonoids; Hesperidin; Mixed Function Oxygenases; Oxidoreductases; Plant Proteins; Synthetic Biology

2021
Potential of Vasoprotectives to Inhibit Non-Enzymatic Protein Glycation, and Reactive Carbonyl and Oxygen Species Uptake.
    International journal of molecular sciences, 2021, Sep-16, Volume: 22, Issue:18

    Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Glycation End Products, Advanced; Hesperidin; Humans; Hydrogen-Ion Concentration; Pyruvaldehyde; Spectrometry, Mass, Electrospray Ionization

2021
Hesperetin Inhibits Expression of Virulence Factors and Growth of
    International journal of molecular sciences, 2021, Sep-17, Volume: 22, Issue:18

    Topics: Bacterial Proteins; Blotting, Western; Flavanones; Helicobacter Infections; Helicobacter pylori; Hesperidin; Stomach Neoplasms; Virulence Factors

2021
Polyphenols from Citrus Tacle
    Molecules (Basel, Switzerland), 2021, Sep-21, Volume: 26, Issue:18

    Topics: Citrus; Dietary Supplements; Enzyme Inhibitors; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Models, Molecular; Molecular Docking Simulation; Plant Extracts; Polyphenols; Protein Binding; Protein Conformation

2021
Hesperetin may alleviate the development of doxorubicin-induced pulmonary toxicity by decreasing oxidative stress and apoptosis in male rats.
    Tissue & cell, 2021, Volume: 73

    Topics: Animals; Apoptosis; Body Weight; Caspase 3; Cytochromes c; Doxorubicin; Hesperidin; Lung; Male; Organ Size; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats, Sprague-Dawley; RNA, Messenger

2021
Hesperetin inhibits KSHV reactivation and is reversed by HIF1α overexpression.
    The Journal of general virology, 2021, Volume: 102, Issue:11

    Topics: Antiviral Agents; Apoptosis; Gene Expression Regulation, Viral; Herpesviridae Infections; Herpesvirus 8, Human; Hesperidin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Viral Proteins; Virus Activation; Virus Replication

2021
Pathological analysis of hesperetin-derived small cell lung cancer by artificial intelligence technology under fiberoptic bronchoscopy.
    Mathematical biosciences and engineering : MBE, 2021, 09-30, Volume: 18, Issue:6

    Topics: Artificial Intelligence; Bronchoscopy; Fiber Optic Technology; Hesperidin; Humans; Lung Neoplasms; Small Cell Lung Carcinoma; Technology

2021
Green synthesis of kudzu vine biochar decorated graphene-like MoSe
    Chemosphere, 2022, Volume: 289

    Topics: Charcoal; Graphite; Hesperidin; Oxidoreductases; Pueraria

2022
The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3β and apoptosis in male rats.
    Chemico-biological interactions, 2022, Jan-25, Volume: 352

    Topics: Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycogen Synthase Kinase 3 beta; Hesperidin; Hypoglycemic Agents; Inflammation; Kidney; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Quercetin; Rats; Rats, Wistar; Trifolium

2022
The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1).
    Toxicology and applied pharmacology, 2022, 01-15, Volume: 435

    Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Autophagy-Related Protein 5; Beclin-1; Doxorubicin; Dynamins; Gene Expression; Hesperidin; Male; MicroRNAs; Oxidative Stress; Rats; Rats, Sprague-Dawley; Testicular Diseases; Testis; TOR Serine-Threonine Kinases

2022
Neuroprotective Effects of Hesperetin in Regulating Microglia Polarization after Ischemic Stroke by Inhibiting TLR4/NF-
    Journal of healthcare engineering, 2021, Volume: 2021

    Topics: Animals; Cytokines; Hesperidin; Interleukin-10; Ischemic Stroke; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; NF-kappa B; RNA, Messenger; Toll-Like Receptor 4; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2021
O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway.
    Toxicology, 2022, 01-30, Volume: 466

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholesterol; Cytokines; Hesperidin; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Signal Transduction; Transcription Factor RelA; Transcription Factors; Triglycerides

2022
Hesperetin Inhibits Sphingosylphosphorylcholine-Induced Vascular Smooth Muscle Contraction by Regulating the Fyn/Rho-Kinase Pathway.
    Journal of cardiovascular pharmacology, 2022, 01-05, Volume: 79, Issue:4

    Topics: Animals; Calcium; Hesperidin; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Phosphorylcholine; rho-Associated Kinases; Sphingosine; Swine

2022
From the Physicochemical Characteristic of Novel Hesperetin Hydrazone to Its In Vitro Antimicrobial Aspects.
    Molecules (Basel, Switzerland), 2022, Jan-27, Volume: 27, Issue:3

    Topics: Anti-Bacterial Agents; Coordination Complexes; Copper; Gram-Negative Bacteria; Gram-Positive Bacteria; Hesperidin; Hydrazones; Microbial Sensitivity Tests

2022
Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives.
    Molecules (Basel, Switzerland), 2022, Jan-27, Volume: 27, Issue:3

    Topics: Antineoplastic Agents; Antioxidants; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Hesperidin; Humans; MCF-7 Cells; Neoplasms

2022
Production of hesperetin from naringenin in an engineered Escherichia coli consortium.
    Journal of biotechnology, 2022, Mar-10, Volume: 347

    Topics: Escherichia coli; Flavanones; Hesperidin

2022
The Citrus Flavonoid Hesperetin Encounters Diabetes-Mediated Alzheimer-Type Neuropathologic Changes through Relieving Advanced Glycation End-Products Inducing Endoplasmic Reticulum Stress.
    Nutrients, 2022, Feb-10, Volume: 14, Issue:4

    Topics: Alzheimer Disease; Apoptosis; Citrus; Diabetes Mellitus; Endoplasmic Reticulum Stress; Flavonoids; Glycation End Products, Advanced; Hesperidin; Humans

2022
Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:35

    Topics: Animals; Cardiovascular System; Hesperidin; Inflammation; Lipids; Male; Oxidative Stress; Particulate Matter; Rats; Rats, Wistar; Vehicle Emissions

2022
Hesperetin (citrus peel flavonoid aglycone) encapsulation using pea protein-high methoxyl pectin electrostatic complexes: complex optimization and biological activity.
    Journal of the science of food and agriculture, 2022, Volume: 102, Issue:12

    Topics: Citrus; Citrus sinensis; Flavonoids; Hesperidin; Pea Proteins; Pectins; Polyphenols; Static Electricity; Water

2022
Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 149

    Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Transport Proteins, Facilitative; Hesperidin; Hypoglycemic Agents; Insulin; Liver; Phosphatidylinositol 3-Kinases; Plant Extracts; Quercetin; Rats; Rats, Wistar; Receptor, Insulin; Streptozocin; Trifolium

2022
Amorphous Inclusion Complexes: Molecular Interactions of Hesperidin and Hesperetin with HP-Β-CD and Their Biological Effects.
    International journal of molecular sciences, 2022, Apr-04, Volume: 23, Issue:7

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Biological Availability; Calorimetry, Differential Scanning; Hesperidin; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction

2022
Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2?
    Journal of food biochemistry, 2022, Volume: 46, Issue:9

    Topics: COVID-19 Drug Treatment; Hesperidin; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; SARS-CoV-2

2022
Hesperetin alleviates DMH induced toxicity via suppressing oxidative stress and inflammation in the colon of Wistar rats.
    Environmental toxicology, 2022, Volume: 37, Issue:9

    Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Catalase; Colon; Colonic Neoplasms; Glutathione; Hesperidin; Inflammation; Mucins; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase

2022
Hesperetin derivative decreases CCl
    Journal of biochemical and molecular toxicology, 2022, Volume: 36, Issue:10

    Topics: Animals; Cell Line; Hedgehog Proteins; Hesperidin; Liver; Liver Cirrhosis; Mice; Patched-1 Receptor; Transforming Growth Factor beta1

2022
Hesperetin-Based Hydrogels Protect the Skin against UV Radiation-Induced Damage.
    AAPS PharmSciTech, 2022, Jun-21, Volume: 23, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Hesperidin; Hydrogels; Oxidative Stress; Peroxidase; Rats; Skin; Superoxide Dismutase; Ultraviolet Rays

2022
Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles.
    Colloids and surfaces. B, Biointerfaces, 2022, Volume: 217

    Topics: Cell Line, Tumor; Cell Proliferation; Chitosan; Colonic Neoplasms; Doublecortin-Like Kinases; Folic Acid; Hesperidin; Humans; Intracellular Signaling Peptides and Proteins; Nanoparticles; Neoplastic Stem Cells; Protein Serine-Threonine Kinases

2022
Hesperetin activated SIRT1 neutralizes cadmium effects on the early bovine embryo development.
    Theriogenology, 2022, Sep-01, Volume: 189

    Topics: Animals; Cadmium; Cattle; Embryonic Development; Female; Hesperidin; Molecular Docking Simulation; Nuclear Respiratory Factors; Sirtuin 1

2022
7-O-(2- (Propylamino)-2-oxoethyl) hesperetin attenuates inflammation and protects against alcoholic liver injury by NLRP12.
    International immunopharmacology, 2022, Volume: 110

    Topics: Animals; Anti-Inflammatory Agents; Ethanol; Hesperidin; Inflammation; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver; Liver Diseases, Alcoholic; Mice; Mice, Inbred C57BL; NF-kappa B; RAW 264.7 Cells

2022
Hesperetin attenuates UVA-induced photodamage in human dermal fibroblast cells.
    Journal of cosmetic dermatology, 2022, Volume: 21, Issue:11

    Topics: Cells, Cultured; Fibroblasts; Hesperidin; Humans; Skin; Skin Aging; Ultraviolet Rays

2022
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice.
    Journal of biomedical science, 2022, Jul-24, Volume: 29, Issue:1

    Topics: Aging; Animals; Autophagy-Related Proteins; Hesperidin; Humans; Longevity; Mice; Mice, Knockout; Nerve Tissue Proteins

2022
    European journal of inorganic chemistry, 2022, Apr-08, Volume: 2022, Issue:10

    Topics: Accidents, Occupational; Adult; Animals; Anxiety; beta Catenin; Chromatography, High Pressure Liquid; Chronic Disease; Cities; Depression; Drugs, Chinese Herbal; Flavonoids; Heat Stroke; Hesperidin; Humans; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-10; Interleukin-6; Kruppel-Like Factor 4; Macrophages, Alveolar; Medical Staff; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Occupational Health; Occupational Injuries; Occupational Stress; Occupations; PPAR gamma; Pulmonary Fibrosis; RNA, Messenger; Sanitation; Silicon Dioxide; Sinusitis; Stress, Psychological; Surveys and Questionnaires; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; X-Box Binding Protein 1; Young Adult

2022
Hesperetin mitigates sorafenib-induced cardiotoxicity in mice through inhibition of the TLR4/NLRP3 signaling pathway.
    PloS one, 2022, Volume: 17, Issue:8

    Topics: Animals; Cardiotoxicity; Hesperidin; Interleukin-6; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sorafenib; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2022
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers.
    Pharmaceutical development and technology, 2022, Volume: 27, Issue:7

    Topics: Abelmoschus; Catalase; Cations; Cell Line, Tumor; Colonic Neoplasms; Excipients; Hesperidin; Hydrogen-Ion Concentration; Liposomes; Oxaliplatin

2022
Nanophytosomes of hesperidin and of hesperetin: Preparation, characterization, and in vivo evaluation.
    Biotechnology and applied biochemistry, 2023, Volume: 70, Issue:2

    Topics: Hesperidin; Phospholipids; X-Ray Diffraction

2023
Hesperetin from Root Extract of
    International journal of molecular sciences, 2022, Sep-07, Volume: 23, Issue:18

    Topics: A549 Cells; Anti-Inflammatory Agents; Antipyretics; Caspase 1; Clerodendrum; COVID-19 Drug Treatment; Cytokines; Flavonoids; Hesperidin; Humans; Inflammasomes; Interleukin-18; Interleukin-6; Lung; NLR Family, Pyrin Domain-Containing 3 Protein; Petasites; Plant Extracts; Proto-Oncogene Proteins c-akt; SARS-CoV-2; Solvents; Spike Glycoprotein, Coronavirus; Transcription Factor AP-1

2022
Hesperetin induces apoptosis in A549 cells via the Hsp70‑mediated activation of Bax.
    International journal of oncology, 2022, Volume: 61, Issue:6

    Topics: A549 Cells; Apoptosis; bcl-2-Associated X Protein; Flavonoids; Hesperidin; HSP70 Heat-Shock Proteins; Humans; Ligases; Proteasome Endopeptidase Complex

2022
Multiomics Analyses Reveal That Long-Term Intake of Hesperetin-7-
    Journal of agricultural and food chemistry, 2022, Nov-30, Volume: 70, Issue:47

    Topics: Animals; Bacteria; Bile Acids and Salts; Gastrointestinal Microbiome; Glucosides; Hesperidin; Liver; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S

2022
Bioactivity-boosting strategy based on combination of anti-allergic O-methylated catechin with a Citrus flavanone, hesperetin.
    Journal of natural medicines, 2023, Volume: 77, Issue:2

    Topics: Animals; Anti-Allergic Agents; Catechin; Flavanones; Hesperidin; Immunoglobulin E; Mice; Passive Cutaneous Anaphylaxis; Rats

2023
Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry.
    Scientific reports, 2023, 02-06, Volume: 13, Issue:1

    Topics: Cell Differentiation; Cells, Cultured; Dental Pulp; Dentistry; Hesperidin; Humans; Osteogenesis; Stem Cells

2023
Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents.
    Molecules (Basel, Switzerland), 2023, Feb-11, Volume: 28, Issue:4

    Topics: Collagenases; Hesperidin; Humans; Hyaluronoglucosaminidase; Pancreatic Elastase; Rhamnose; Skin Aging

2023
Preparation and physicochemical properties characterization of hesperetin-grafted pectin conjugate.
    International journal of biological macromolecules, 2023, Jul-15, Volume: 243

    Topics: Hesperidin; Pectins; X-Ray Diffraction

2023
Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner.
    Chemico-biological interactions, 2023, Sep-01, Volume: 382

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Hesperidin; Humans; Molecular Docking Simulation; Reactive Oxygen Species; Superoxide Dismutase

2023
Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies.
    Journal of agricultural and food chemistry, 2023, Nov-01, Volume: 71, Issue:43

    Topics: alpha-Synuclein; Amyloid; Flavonoids; Hesperidin; Humans; Parkinson Disease

2023