hesperidin has been researched along with diosmin in 121 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.65) | 18.7374 |
| 1990's | 41 (33.88) | 18.2507 |
| 2000's | 27 (22.31) | 29.6817 |
| 2010's | 40 (33.06) | 24.3611 |
| 2020's | 11 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Ash, K; Grohmann, K; Manthey, CL; Manthey, JA; Montanari, A | 1 |
| Bronze, MR; Mendes, T; Serra, H; Simplício, AL | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Han, C; Kong, L; Lei, J; Li, S; Liu, C; Peng, W; Wang, Z; Xu, X | 1 |
| Kalra, S; Khatik, GL; Kumar, GN; Kumar, R; Narang, R; Nayak, SK; Singh, SK; Sudhakar, K | 1 |
| Haigle, J; Labrid, C; Maziere, C; Maziere, JC; Morliere, P; Perdrix, L; Santus, R | 1 |
| Witte, S | 1 |
| Foo, CL; Goh, HS; Ho, YH; Seow-Choen, F | 1 |
| Nicolaides, AN; Struckmann, JR | 1 |
| Launois, R | 1 |
| Labrid, C | 1 |
| Amato, C | 1 |
| Guillot, B | 1 |
| Geroulakos, G; Nicolaides, AN | 1 |
| Bodinier, MC; Jean, T | 1 |
| Cospite, M | 1 |
| Godeberge, P | 1 |
| Meyer, OC | 1 |
| Galley, P; Thiollet, M | 1 |
| Carrié, ML; Cypriani, B; Damon, M; de Paulet, AC; Le Doucen, C; Limasset, B; Roussie, M | 1 |
| Friesenecker, B; Intaglietta, M; Tsai, AG | 1 |
| Bouskela, E; Donyo, KA; Verbeuren, TJ | 1 |
| Calinon, F; Delbarre, B; Delbarre, G | 1 |
| Bollinger, A; Fischer, M; Franzeck, UK; Herrig, I; Hoffmann, U | 1 |
| Belcaro, G; Cesarone, MR; De Gregoris, P; de Sanctis, MT; Février, B; Incandela, L; Laurora, G; Wargon, C | 1 |
| Allegra, C; Bartolo, M; Carioti, B; Cassiani, D | 1 |
| Bouskela, E; Cyrino, FZ; Lerond, L | 3 |
| Geroulakos, G; Ibegbuna, V; Leon, M; Nicolaides, AN; Sowade, O | 1 |
| Debure, C; Dereure, O; Dubeaux, D; Février, B; Gillet-Terver, MN; Guilhou, JJ; Guillot, B; Levesque, H; Marzin, L; Mignot, J; Ouvry, P; Pillion, G; Van Landuyt, H; Zuccarelli, F | 1 |
| Février, B; Pecking, AP; Pillion, G; Wargon, C | 1 |
| Fukutani, K; Hara, A; Makita, H; Mori, H; Ogawa, H; Ohnishi, M; Satoh, K; Sumida, T; Tanaka, T | 1 |
| Bogachev, VIu; Domoradskaia, AI; Iablokov, EG | 1 |
| Fukutani, K; Hara, A; Kakumoto, M; Kawabata, K; Makita, H; Mori, H; Ogawa, H; Satoh, K; Sumida, T; Tanaka, T | 1 |
| Bouskela, E; Donyo, KA | 1 |
| Hara, A; Kakumoto, M; Kawabata, K; Makita, H; Mori, H; Ogawa, H; Satoh, K; Sumida, T; Tanaka, T | 1 |
| Aggarwal, N; Buckshee, K; Takkar, D | 1 |
| Deguchi, T; Hirose, Y; Kawada, Y; Mori, H; Tanaka, T; Yang, M | 1 |
| Debure, C; Dubeaux, D; Février, F; Gillet-Terver, MN; Guilhou, JJ; Guillot, B; Levesque, H; Marzin, L; Mignot, J; Nicolaïdes, AN; Ouvry, P; Pillion, G; Van Landuyt, H; Zuccarelli, F | 1 |
| Andre, J; Guillot, R; Hadjiisky, P; Kassab, JP; Mozère, G; Ogneva, V; Peyroux, J; Sternberg, M | 1 |
| Bellangeon, M; Chignier, E; Lerond, L; McGregor, JL; McGregor, L; Rousselle, C | 1 |
| Crespo, ME; Cruz, T; Gálvez, J; Ocete, MA; Zarzuelo, A | 1 |
| Bergan, JJ; Lerond, L; Schmid-Schönbein, GW; Takase, S | 1 |
| La Torre, F; Nicolai, AP; Otti, M | 1 |
| Ho, YH; Seow-Choen, F; Tan, M | 1 |
| Manthey, JA | 1 |
| El-Domiaty, MM; El-Shafae, AM | 1 |
| Bellocco, E; Caristi, C; Leuzzi, U; Panzera, V; Toscano, G; Vadalà, R | 1 |
| Borisov, AV; Borisova, RP; Bubnova, NA | 1 |
| Gabrieli, C; Georgarakis, M; Kanaze, FI; Kokkalou, E; Niopas, I | 1 |
| BOOTH, AN; DeEDS, F; JONES, FT | 1 |
| Sirotin, BZ; Zhmerenetskĭ, KV | 1 |
| Bottino, DA; Bouskela, E; Cyrino, FZ; Lerond, L | 1 |
| Kharkevich, DA | 1 |
| Eaglstein, WH; Falabella, A; Kirsner, RS; Trent, JT | 1 |
| Kosorok, P; Mlakar, B | 1 |
| Jedlicka, V; Kalac, J; Veverková, L; Wechsler, J | 1 |
| Kirienko, AI; Oganov, RG; Savel'ev, VS; Shal'nova, SA; Zolotukhin, IA | 1 |
| Blázovics, A; Fehér, E; Kurucz, T; Lugasi, A; Pallai, Z; Rapavi, E; Székely, E; Szentmihályi, K | 1 |
| Baeshko, AA; Egorova, VV; Goretskaia, IV; Orlovskiĭ, IuN; Savitskaia, TV; Somova, OA; Ulezko, EA; Zhuk, GV | 1 |
| Bogachev, VY; Burleva, EP; Katelnitsky, II; Kirienko, AI; Pokrovsky, AV; Sabelnikov, VV; Sapelkin, SV; Saveljev, VS; Shvalb, PG; Tolstikhin, VY; Voskanian, YE; Vozlubleny, SI; Zhukov, BN; Zolotukhin, IA | 1 |
| Bakradze, M; Koridze, Kh; Ladashvili, L; Taboridze, I | 1 |
| Bouskela, E; Paysant, J; Sansilvestri-Morel, P; Verbeuren, TJ | 1 |
| Aliev, ES; Aliev, SA; Ibishov, KG | 1 |
| Rovenská, E; Rovenský, J; Stancíková, M; Stvrtinová, V; Svík, K | 1 |
| Erer, D; Ereren, E; Gokgoz, L; Halit, V; Iriz, E; Oktar, L; Poyraz, A; Soncul, H; Vural, C | 1 |
| Gabrieli, C; Georgarakis, M; Kanaze, FI; Kokkalou, E; Niopas, I; Termentzi, A | 1 |
| Kasmas, S; Niopas, I; Spanakis, M | 1 |
| Rovenská, E; Rovenský, J; Stancíková, M; Stvrtina, S; Stvrtinová, V; Svík, K | 1 |
| Sapelkin, SV | 1 |
| Gudymovich, VG; Stoĭko, IuM | 1 |
| Koviazina, IO; Lazebnik, LB; Patrushev, NB | 1 |
| Babaei, AB; Barfi, B; Dust, AM; Hadjmohammadi, MR; Iranshahi, M; Peyrovi, M; Saeidi, I | 1 |
| Agrifoglio, C; Alvisi, G; Bacci, G; Baiocchi, C; Buratta, M; Di Pierro, F; Gennaioli, F; Lucarelli, M; Martinoli, A; Monsù, G; Spinelli, G; Vitali, F | 1 |
| Davies, AH; Kiriakidis, S; Lim, CS; Paleolog, EM | 1 |
| Bogachev, VIu; Golovanova, OV; Kuzhetsov, AN; Shekoian, AO | 1 |
| Altun, T; Aydogan, A; Barlas, AM; Celepli, S; Cengiz, A; Demirel, AH; Gonultas, M; Kilicoglu, B; Kilicoglu, SS; Kuru, S; Tabak, S | 1 |
| Akman, T; Armagan, A; Aylak, F; Bas, E; Dogan, F; Oksay, T | 1 |
| Aun, R; Belczak, SQ; Beserra, J; Campos, W; Nering, G; Sincos, IR | 1 |
| Gudymovich, VG; Iakovleva, NM; Nikitina, AM; Stoĭko, IuM | 1 |
| Grigorova-Borsos, AM; Guillot, R; Jacolot, P; Kassab, I; Peyroux, J; Sternberg, M; Tessier, F; Urios, P | 1 |
| Gonsales, AK; Tarkovskiĭ, aA; Vikhert, TA; Zasorina, MA; Zudin, AM | 1 |
| Demidova, aK; Krivosheeva, NV; Rychkova, IV; Zubarev, AR | 1 |
| Frolov, DV; Linchenko, DV; Poliantsev, AA; Shchelokova, IuV | 1 |
| Bulatov, VL; Krylov, DV; Remizov, AS; Rezvantsev, MV; Shaĭdakov, EV; Son'kin, IN | 1 |
| Altomare, DF; Amato, A; Basso, L; Giannini, I; Marranci, M; Pecorella, G; Pennisi, D; Tafuri, S; Tricomi, N | 1 |
| Battiloro, L; Chiurazzi, M; Colantuoni, A; Di Maro, M; Lapi, D; Mastantuono, T; Muscariello, E; Sabatino, L | 1 |
| Anderson, LG; Azzam, EI; Bai, B; Ballent, M; Barrett, T; Beecher, C; Ben Amara, I; Ben Saad, H; Boerwinkle, E; Bonelli, F; Bouchet, P; Boudawara, O; Boudawara, T; Bressler, J; Brundha, C; Bukhari, S; Burger, R; Chang, LC; Chen, X; Cheng, Y; Coyne, DW; Crosbie, E; Cuaderes, E; de Toledo, SM; DeLuca, HF; DeShea, L; Devarakonda, K; Dias, LC; Dickerson, AS; Driss, D; Duda, TF; Dunn, AM; Dusso, A; Edoff, M; Ellouz Chaabouni, S; Fjällström, V; Flandre, D; Fujisawa, Y; Garland, RM; Giulivi, C; Groß, MA; Grove, ML; Hakim, A; Hamilton, ER; Han, L; Henry, F; Herlein, A; Hersey, SP; Hessabi, M; Huang, TQ; Iacono, WG; Jain, S; Jia, Y; Karuppuchamy, S; Kerzeli, IK; Keyes, M; Kim, MH; Klinger, S; Kostenbader, K; Kotipalli, R; Kotsianidis, I; Kózka, M; Kucharzewski, M; Lamb, WL; Lamprianidou, E; Leadlay, PF; Lee, MS; Lee, YS; Li, H; Li, T; Lifschitz, AL; Loveland, KA; Ma, J; Maté, LM; Matsui, T; McGue, MK; McLaughlin, W; Meier, RR; Meissner, G; Mereiter, K; Meyer, C; Miltiades, P; Montgomery, J; Morton, TL; Mounir Zeghal, K; Murphy, AC; Muscher-Banse, AS; Nagasaki, K; Nakou, E; Napoli, E; Nicolas, F; Ogata, T; Olivera, BM; Olson, GT; Papamichos, SI; Pasek, DA; Pietrzycka, A; Piketh, S; Podgorski, AL; Prediger, P; Puillandre, N; Rahbar, MH; Rosewarne, PJ; Rostvall, F; Samek, DR; Samms-Vaughan, M; Schnepel, N; Shakespeare-Pellington, S; Shibata, M; Shingler, T; Smucny, J; Song, G; Song, Q; Sorooshian, A; Spanoudakis, E; Stebbing, PD; Stevens, KE; Stpniewski, M; Takasu, A; Tregellas, JR; Urbanek, T; Valcour, A; Vermang, B; Vijayan, A; Virkel, G; Wall, JV; Wang, C; Wang, J; Wang, N; Wang, W; Wang, Y; Wätjen, JT; Webster, L; Weissensteiner, W; Wilkens, MR; Wong, S; Wu, C; Wu, Q; Yamada, T; Yamaguchi, R; Yue, J; Zhou, Y; Zierold, C; Zirakzadeh, A; Zou, MX | 1 |
| Hnátek, L | 1 |
| Karetová, D | 1 |
| Korzhyk, NP | 1 |
| González Ochoa, A | 1 |
| Nikolaichuk, AI; Tsukanov, YT | 1 |
| Santos, MERC; Schnaider, TB; Toledo, RR | 1 |
| Cerdà, V; Clavijo, S; Portugal, L; Sammani, MS; Seddik, H; Suárez, R | 1 |
| Kang, JS; Kim, TI; Kim, YH; Min, BS; Son, JK; Woo, MH; Zhao, BT | 1 |
| Blanc-Guillemaud, V; Bouskela, E; Cyrino, FZ; das Graças C de Souza, M; de Carvalho, JJ | 1 |
| Carrieri, P; Corsale, I; Martellucci, J; Panicucci, S; Piccolomini, A; Rigutini, M; Verre, L | 1 |
| Bogachev, VY; Boldin, BV; Turkin, PY | 1 |
| Abdel-Rafei, MK; Hassan, AA; Thabet, NM | 1 |
| Bogomazov, AM; Golovko, EB; Zagriadskiĭ, EA | 1 |
| Selim, DA; Shawky, E | 1 |
| Bhattacharyya, S; Chattopadhyay, N; Chattopadhyay, S; Gayen, JR; Mohamed, R; Pal China, S; Pal, S; Porwal, K; Sanyal, S; Singh, P | 1 |
| Cerdà, V; Clavijo, S; González, A; Sammani, MS | 1 |
| Abdel-Daim, MM; AlBasher, G; Aleya, L; Alfarraj, S; Almeer, R; Bahbah, EI; Bungău, SG; Elhelaly, AE; Fouda, MMA | 1 |
| El-Ashmawy, NE; Haggag, YA; Okasha, KM | 1 |
| Bultas, J; Karetová, D; Suchopár, J | 1 |
| Benigni, JP; Cazaubon, M; Gouhier-Kodas, C; Jabbour, V; Steinbruch, M | 1 |
| Monjotin, N; Tenca, G | 1 |
| Bagnati, M; Basile, M; Bauce, G; Bellomo, G; Dianzani, U; Grigollo, B; Prodam, F; Puricelli, C; Rolla, R | 1 |
| Gurjar, M; Kumar, D; Kumar, S; Ladaniya, MS | 1 |
| Abdelrahim, MEA; Hamed, EO; Mahmoud, MA; Osama, H | 1 |
| Soukop, J; Večeřa, R | 1 |
| Baniwal, P; Inbaraj, BS; Kashyap, P; Kumar, S; Sharma, M; Shikha, D; Singh, N; Sridhar, K; Thakur, M; Yadav, YS | 1 |
| Apkhanova, TV; Fesyun, AD; Gushchina, NV; Konchugova, TV; Kulchitskaya, DB; Musaeva, OM; Yakovlev, MY | 1 |
| Arslan, A; Kahraman, ME; Küçükosmanoğlu, I; Özbuğday, Y | 1 |
12 review(s) available for hesperidin and diosmin
| Article | Year |
|---|---|
Recent advancements in mechanistic studies and structure activity relationship of F
Topics: Animals; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium; Proton-Translocating ATPases; Structure-Activity Relationship | 2019 |
Flavonoids. A review of the pharmacology and therapeutic efficacy of Daflon 500 mg in patients with chronic venous insufficiency and related disorders.
Topics: Animals; Chronic Disease; Diosmin; Drug Combinations; Flavonoids; Hesperidin; Humans; Venous Insufficiency | 1994 |
Cellular basis of inflammation, edema and the activity of Daflon 500 mg.
Topics: Animals; Diosmin; Drug Combinations; Edema; Flavonoids; Hesperidin; Inflammation; Leukocytes; Microcirculation; Reperfusion Injury; Skin | 1995 |
Intravital capillaroscopy in patients with chronic venous insufficiency and lymphoedema: relevance to Daflon 500 mg.
Topics: Diosmin; Drug Combinations; Flavonoids; Hesperidin; Humans; Lymphatic System; Lymphedema; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Skin; Venous Insufficiency | 1995 |
[Hemorrhoids and conservative treatment. Review of the literature on the use of diosmin and micronized hesperidin].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Diosmin; Double-Blind Method; Drug Combinations; Female; Flavonoids; Hemorrhoids; Hesperidin; Humans; Lymphedema; Male; Middle Aged; Placebos; Platelet Aggregation Inhibitors; Pregnancy; Thrombophlebitis; Time Factors | 1999 |
Biological properties of flavonoids pertaining to inflammation.
Topics: Animals; Diosmin; Enzyme Inhibitors; Flavonoids; Hesperidin; Histamine; Humans; Inflammation; Phosphodiesterase Inhibitors; Prostaglandin Antagonists; Prostaglandins; Protein Kinase Inhibitors; Transcriptional Activation; Venous Insufficiency | 2000 |
[The principles of action and use of phlebotropic agents].
Topics: Diosmin; Drug Combinations; Flavonoids; Hesperidin; Humans; Sclerotherapy; Varicose Veins; Vasodilator Agents; Venous Insufficiency; Venous Thrombosis | 2004 |
Venous ulcers: pathophysiology and treatment options.
Topics: Anti-Inflammatory Agents; Aspirin; Bandages; Chronic Disease; Debridement; Diosmin; Growth Substances; Hesperidin; Humans; Pentoxifylline; Prognosis; Risk Factors; Sclerotherapy; Severity of Illness Index; Skin Care; Skin Transplantation; Varicose Ulcer; Vasodilator Agents; Wound Healing | 2005 |
[Edema as a measure for severity of chronic venous insufficiency and efficacy of its treatment].
Topics: Chronic Disease; Diosmin; Drug Combinations; Edema; Hesperidin; Humans; Prognosis; Severity of Illness Index; Venous Insufficiency | 2008 |
[Therapeutic potential of micronized purified flavonoid fraction (MPFF) of diosmin and hesperidin in treatment chronic venous disorder].
Topics: Chronic Disease; Diosmin; Europe; Hemorrhoids; Hesperidin; Humans; Lymphedema; Microcirculation; Treatment Outcome; Varicose Ulcer; Venous Insufficiency | 2015 |
Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence.
Topics: Chronic Disease; Diosmin; Flavonoids; Hesperidin; Humans; Randomized Controlled Trials as Topic; Treatment Outcome; Vascular Diseases; Venous Insufficiency | 2021 |
In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease.
Topics: Antiviral Agents; COVID-19 Drug Treatment; Diosmin; Flavonoids; Hesperidin; Humans; Lopinavir; Molecular Docking Simulation; Nelfinavir; Ritonavir; Rutin; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2022 |
32 trial(s) available for hesperidin and diosmin
| Article | Year |
|---|---|
Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy.
Topics: Adult; Diosmin; Drug Combinations; Female; Flavonoids; Hemorrhage; Hemorrhoids; Hesperidin; Humans; Male; Postoperative Complications; Prospective Studies | 1995 |
Advantage of a micronized flavonoidic fraction (Daflon 500 mg) in comparison with a nonmicronized diosmin.
Topics: Adult; Chronic Disease; Diosmin; Dosage Forms; Double-Blind Method; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Male; Middle Aged; Patient Satisfaction; Plethysmography; Venous Insufficiency | 1994 |
Controlled studies of Daflon 500 mg in chronic venous insufficiency.
Topics: Diosmin; Drug Combinations; Flavonoids; Hesperidin; Humans; Plethysmography; Randomized Controlled Trials as Topic; Venous Insufficiency | 1994 |
Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids.
Topics: Acute Disease; Adult; Aged; Diosmin; Double-Blind Method; Drug Combinations; Female; Flavonoids; Hemorrhoids; Hesperidin; Humans; Male; Middle Aged | 1994 |
Daflon 500 mg in the treatment of hemorrhoidal disease: a demonstrated efficacy in comparison with placebo.
Topics: Acute Disease; Chronic Disease; Diosmin; Double-Blind Method; Drug Combinations; Female; Flavonoids; Hemorrhoids; Hesperidin; Humans; Male; Middle Aged | 1994 |
A double-blind, placebo-controlled trial of a new veno-active flavonoid fraction (S 5682) in the treatment of symptomatic capillary fragility.
Topics: Aged; Capillary Fragility; Capillary Resistance; Diosmin; Double-Blind Method; Drug Combinations; Female; Flavonoids; Hemorrhage; Hesperidin; Humans; Male | 1993 |
Laser Doppler and transcutaneous oximetry: modern investigations to assess drug efficacy in chronic venous insufficiency.
Topics: Adult; Blood Gas Monitoring, Transcutaneous; Diosmin; Double-Blind Method; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Middle Aged; Skin; Venous Insufficiency | 1995 |
An original microhaemorheological approach to the pharmacological effects of Daflon 500 mg in severe chronic venous insufficiency.
Topics: Adult; Aged; Diosmin; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Male; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Middle Aged; Rheology; Skin; Venous Insufficiency | 1995 |
Venous elasticity after treatment with Daflon 500 mg.
Topics: Adolescent; Adult; Diosmin; Drug Combinations; Elasticity; Female; Flavonoids; Hesperidin; Humans; Varicose Veins; Veins | 1997 |
Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diosmin; Double-Blind Method; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Leg Ulcer; Male; Middle Aged; Pressure; Treatment Outcome | 1997 |
Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer).
Topics: Aged; Breast Neoplasms; Diosmin; Double-Blind Method; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Lymphedema; Middle Aged | 1997 |
[The drug therapy of chronic venous insufficiency (a trial of the clinical use of the preparation Detralex)].
Topics: Chronic Disease; Diosmin; Drug Combinations; Flavonoids; Hesperidin; Humans; Tablets; Time Factors; Venous Insufficiency | 1996 |
Micronized flavonoid therapy in internal hemorrhoids of pregnancy.
Topics: Acute Disease; Administration, Oral; Adult; Chi-Square Distribution; Confidence Intervals; Diosmin; Dose-Response Relationship, Drug; Drug Compounding; Female; Hemorrhoids; Hesperidin; Humans; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Treatment Outcome | 1997 |
Benefit of a 2-month treatment with a micronized, purified flavonoidic fraction on venous ulcer healing. A randomized, double-blind, controlled versus placebo trial.
Topics: Adolescent; Adult; Aged; Diosmin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Female; Hesperidin; Humans; Leg Ulcer; Male; Middle Aged; Time Factors; Treatment Outcome; Venous Insufficiency; Wound Healing | 1997 |
Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding hemorrhoids: randomized controlled trial.
Topics: Adult; Cathartics; Citric Acid; Dietary Fiber; Diosmin; Drug Combinations; Female; Follow-Up Studies; Gastrointestinal Hemorrhage; Hemorrhoids; Hesperidin; Humans; Ligation; Male; Plant Extracts; Psyllium; Recurrence; Single-Blind Method; Sodium Bicarbonate; Treatment Outcome | 2000 |
[Microcirculation end effect of detralex in patients with chronic venous insufficiency of the lower extremities].
Topics: Chronic Disease; Diosmin; Drug Combinations; Erythrocyte Aggregation; Female; Hesperidin; Humans; Male; Microcirculation; Middle Aged; Severity of Illness Index; Varicose Veins | 2003 |
Flavonoids to reduce bleeding and pain after stapled hemorrhoidopexy: a randomized controlled trial.
Topics: Analgesics; Anti-Inflammatory Agents; Diosmin; Drug Combinations; Female; Flavonoids; Hemorrhoids; Hesperidin; Humans; Intestinal Mucosa; Male; Melena; Middle Aged; Pain, Postoperative; Pelvic Pain; Surgical Stapling; Treatment Outcome | 2005 |
[Analysis of surgical procedures on the vena saphena magna in the Czech Republic and an effect of Detralex during its stripping].
Topics: Adolescent; Adult; Chronic Disease; Diosmin; Drug Combinations; Hesperidin; Humans; Middle Aged; Pain Measurement; Pain, Postoperative; Postoperative Complications; Quality of Life; Saphenous Vein; Vascular Surgical Procedures; Venous Insufficiency | 2005 |
[Congenital anomalies of the inferior vena cava: diagnosis and medical treatment].
Topics: Adolescent; Adult; Diagnosis, Differential; Diosmin; Drug Combinations; Fibrinolytic Agents; Heparin; Hesperidin; Humans; Male; Ultrasonography, Doppler; Vascular Surgical Procedures; Vena Cava, Inferior; Venous Insufficiency | 2007 |
Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS).
Topics: Adult; Aged; Arteries; Combined Modality Therapy; Diosmin; Drug Combinations; Female; Hesperidin; Humans; Middle Aged; Varicose Veins; Vascular Surgical Procedures; Veins | 2007 |
[Monitoring the quality of life in patients with varicose disease of the lower extremities in the use of venarus].
Topics: Adult; Diosmin; Drug Combinations; Female; Hesperidin; Humans; Lower Extremity; Male; Middle Aged; Quality of Life; Thrombophlebitis; Varicose Veins | 2010 |
Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Diosmin; Drug Carriers; Female; Flavonoids; Hemorrhoids; Hesperidin; Humans; Male; Middle Aged; Tablets; Treatment Outcome; Triterpenes; Young Adult | 2011 |
[On advisability of perioperative phleboprotection in endovascular treatment of lower in varicose disease: first initial results of the decision study].
Topics: Administration, Oral; Adult; Compression Bandages; Diosmin; Drug Combinations; Endovascular Procedures; Female; Flavonoids; Hesperidin; Humans; Lower Extremity; Male; Middle Aged; Perioperative Care; Protective Agents; Quality of Life; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome; Varicose Veins; Veins | 2012 |
Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial.
Topics: Biomechanical Phenomena; Brazil; Cardiovascular Agents; Chronic Disease; Coumarins; Diosmin; Double-Blind Method; Drug Therapy, Combination; Edema; Female; Foot Joints; Hesperidin; Humans; Hydroxyethylrutoside; Male; para-Aminobenzoates; Plethysmography; Quality of Life; Range of Motion, Articular; Recovery of Function; Surveys and Questionnaires; Time Factors; Treatment Outcome; Venous Insufficiency | 2014 |
[Efficacy of Venarus in treatment of patients with post-thrombotic disease of lower limbs].
Topics: Compression Bandages; Diosmin; Drug Combinations; Drug Monitoring; Female; Flavonoids; Hesperidin; Humans; Male; Middle Aged; Pain Measurement; Postthrombotic Syndrome; Quality of Life; Retrospective Studies; Treatment Outcome; Venous Thrombosis | 2014 |
Flavonoids mixture (diosmin, troxerutin, hesperidin) in the treatment of acute hemorrhoidal disease: a prospective, randomized, triple-blind, controlled trial.
Topics: Acute Disease; Adult; Aged; Analgesics; Anticoagulants; Chi-Square Distribution; Diosmin; Drug Combinations; Edema; Epidemiologic Research Design; Female; Hemorrhoids; Hesperidin; Humans; Hydroxyethylrutoside; Male; Middle Aged; Pain Measurement; Prospective Studies; Rectal Prolapse; Research Design; Thrombosis; Young Adult | 2015 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adult; Advanced Oxidation Protein Products; Aged; Aged, 80 and over; Analgesics, Opioid; Animals; Antibodies, Monoclonal; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Automation; Benzaldehydes; Bromates; Calcifediol; Calcitriol; Carcinoma, Squamous Cell; Catalase; Chromatography, Liquid; Coloring Agents; Cross-Over Studies; Cross-Sectional Studies; Cytochrome P-450 CYP3A; Cytokines; Diabetic Foot; Diabetic Neuropathies; Diagnostic Self Evaluation; Diosmin; DNA Damage; Double-Blind Method; Drug Combinations; Electrodes; Endothelin-1; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Exercise; Female; Follow-Up Studies; Gene Expression Regulation; Glutathione; Hesperidin; Humans; Illicit Drugs; Indians, North American; Injections, Intravenous; Interferometry; Interleukin-1beta; Interleukin-6; Interviews as Topic; Ions; Jejunum; Kidney; Leukocyte Count; Lipid Peroxidation; Lithium; Liver; Luminescent Measurements; Male; Mice; Middle Aged; Monocytes; Nanostructures; Oklahoma; Organ Specificity; Oxidative Stress; Oxycodone; Photochemistry; Predictive Value of Tests; Pregnane X Receptor; Preoperative Period; Prescription Drugs; Receptors, Steroid; Reference Values; Reproducibility of Results; Retinoid X Receptor alpha; Retrospective Studies; RNA, Messenger; Rumen; Sheep, Domestic; Shoes; Solar Energy; Superoxide Dismutase; Survival Rate; Tandem Mass Spectrometry; Titanium; Treatment Outcome; Tumor Necrosis Factor-alpha; Varicose Veins; Vitamin D; Water Pollutants, Chemical; Weight-Bearing; Young Adult | 2015 |
Sulodexide and phlebotonics in the treatment of venous ulcer.
Topics: Adult; Aged; Dermatitis; Diosmin; Drug Therapy, Combination; Female; Glycosaminoglycans; Hesperidin; Humans; Male; Mexico; Middle Aged; Scleroderma, Localized; Treatment Outcome; Varicose Ulcer; Wound Healing | 2017 |
Effect of Pycnogenol on the Healing of Venous Ulcers.
Topics: Administration, Oral; Aged; Brazil; Diosmin; Drug Administration Schedule; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Longitudinal Studies; Male; Middle Aged; Plant Extracts; Prospective Studies; Time Factors; Treatment Outcome; Varicose Ulcer; Wound Healing | 2017 |
Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study.
Topics: Adult; Aged; Diosmin; Double-Blind Method; Drug Combinations; Female; Gastrointestinal Hemorrhage; Hemorrhoids; Hesperidin; Humans; Hydroxyethylrutoside; Italy; Male; Middle Aged; Prospective Studies; Quercetin; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult | 2018 |
The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diosmin; Hesperidin; Humans; Hypoglycemic Agents; Metabolic Syndrome; Metabolome | 2023 |
[Non-drug methods of treatment of post-thrombophlebitic syndrome].
Topics: Carbon Dioxide; Diosmin; Hesperidin; Humans; Laser-Doppler Flowmetry; Syndrome; Venous Insufficiency | 2022 |
77 other study(ies) available for hesperidin and diosmin
| Article | Year |
|---|---|
Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes.
Topics: Citrus; Cyclic AMP; Flavonoids; Humans; In Vitro Techniques; Lipopolysaccharides; Monocytes; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 1999 |
Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.
Topics: Caco-2 Cells; Electrophoresis, Capillary; Flavanones; Flavones; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Molecular Structure; Molecular Weight | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Flavones; Histone Demethylases; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Structure-Activity Relationship | 2019 |
Daflon as a cellular antioxidant and a membrane-stabilizing agent in human fibroblasts irradiated by ultraviolet A radiation.
Topics: Antioxidants; Arachidonic Acids; Cell Membrane; Cells, Cultured; Copper; Diosmin; Fibroblasts; Hesperidin; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Ultraviolet Rays; Vitamin E | 1991 |
The influence of the fibrinolytic system on the affinity of fibrinogen for the endothelial-plasma interface.
Topics: Animals; Diosmin; Endothelium, Vascular; Female; Fibrinogen; Fibrinolysis; Hesperidin; Microcirculation; Protein Binding; Rats; Tissue Plasminogen Activator | 1988 |
At the Crossroads of Venous Insufficiency and Hemorrhoidal Disease: Daflon 500 mg. Proceedings of a symposium. Vienna, Austria, January 31, 1992.
Topics: Diosmin; Drug Combinations; Flavonoids; Hemorrhoids; Hesperidin; Humans; Venous Insufficiency | 1994 |
At the crossroads of venous insufficiency and hemorrhoidal disease: Daflon 500 mg--repercussions of venous insufficiency on everyday life.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Aged, 80 and over; Diosmin; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Male; Middle Aged; Pain; Quality of Life; Varicose Veins; Venous Insufficiency | 1994 |
Pharmacologic properties of Daflon 500 mg.
Topics: Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Dinoprostone; Diosmin; Dogs; Drug Combinations; Edema; Flavonoids; Hesperidin; Inflammation; Kidney Glomerulus; Lymph; Muscles; Rats; Thoracic Duct; Thromboxane B2 | 1994 |
Techniques used to evaluate the cutaneous microcirculation: application of photoplethysmography to the assessment of a phlebotropic agent in the treatment of leg ulcers.
Topics: Blood Pressure; Diosmin; Drug Combinations; Flavonoids; Hesperidin; Humans; Leg Ulcer; Microcirculation; Photoplethysmography; Skin; Varicose Ulcer; Venous Insufficiency | 1994 |
Mediators involved in inflammation: effects of Daflon 500 mg on their release.
Topics: Alloxan; Animals; Anti-Inflammatory Agents; Blood Glucose; Diabetes Mellitus, Experimental; Diosmin; Drug Combinations; Flavonoids; Free Radicals; Granuloma; Hesperidin; Humans; Inflammation; Kidney Glomerulus; Macrophages; Mice; Neutrophils; Permeability; Prostaglandins; Rats; Thromboxane B2 | 1994 |
Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease.
Topics: Animals; Clinical Trials as Topic; Diosmin; Drug Combinations; Flavonoids; Hemorrhoids; Hesperidin; Humans; Mice; Rats; Rats, Wistar; Venous Insufficiency | 1994 |
Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils.
Topics: Acridines; Antioxidants; Diosmin; Drug Combinations; Free Radicals; Hesperidin; Humans; Luminescent Measurements; Luminol; Neutrophils; Peroxidase; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 1993 |
Effects of Daflon 500 mg on increased microvascular permeability in normal hamsters.
Topics: Animals; Bradykinin; Capillary Permeability; Cheek; Cricetinae; Diosmin; Drug Combinations; Flavonoids; Hesperidin; Histamine; Leukotriene B4; Male | 1995 |
Effect of Daflon 500 mg, a flavonoid drug, on neurological signs, levels of free radicals and electroretinogram in the gerbil after ischemia-reperfusion injury.
Topics: Animals; Behavior, Animal; Brain Ischemia; Diosmin; Drug Combinations; Electroretinography; Female; Flavonoids; Free Radicals; Gerbillinae; Hesperidin; Lipid Peroxidation; Male; Reperfusion Injury; Retina | 1995 |
Microvascular reactivity after ischemia/reperfusion in the hamster cheek pouch: beneficial effects of different oral doses of S-5682 (Daflon 500 mg).
Topics: Animals; Arterioles; Cheek; Cricetinae; Diosmin; Dose-Response Relationship, Drug; Drug Combinations; Flavonoids; Hesperidin; Ischemia; Male; Mesocricetus; Microcirculation; Regional Blood Flow; Reperfusion; Vasomotor System; Venules | 1997 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Squamous Cell; Diosmin; Drug Screening Assays, Antitumor; Hesperidin; Liver; Male; Micronucleus Tests; Neoplasm Proteins; Neoplasms, Experimental; Papilloma; Polyamines; Rats; Rats, Inbred F344; Tongue Neoplasms | 1997 |
Proceedings of the XII World Congress of the International Union of Phlebology--parallel session entitled medical and socioeconomic impact of venolymphatic disease: benefit of daflon 500 mg. London, 1995.
Topics: Animals; Diosmin; Drug Combinations; Hesperidin; Humans; Vascular Diseases | 1997 |
Modulation of N-methyl-N-amylnitrosamine-induced rat oesophageal tumourigenesis by dietary feeding of diosmin and hesperidin, both alone and in combination.
Topics: Administration, Oral; Animals; Bromodeoxyuridine; Carcinogens; Diet; Diosmin; Esophageal Neoplasms; Hesperidin; Incidence; Male; Nitrosamines; Nucleolus Organizer Region; Polyamines; Precancerous Conditions; Rats; Rats, Wistar | 1997 |
Effects of oral administration of purified micronized flavonoid fraction on increased microvascular permeability induced by various agents and on ischemia/reperfusion in the hamster cheek pouch.
Topics: Administration, Oral; Animals; Capillary Permeability; Cell Adhesion; Cheek; Cricetinae; Diosmin; Drug Combinations; Flavonoids; Hesperidin; Leukocytes; Male; Reperfusion Injury | 1997 |
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Diosmin; Drug Administration Schedule; Drug Combinations; Hesperidin; Intestinal Mucosa; Male; Organ Size; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred F344 | 1997 |
Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice.
Topics: Administration, Oral; Animals; Bromodeoxyuridine; Butylhydroxybutylnitrosamine; Carcinogens; Diosmin; DNA, Neoplasm; Drug Combinations; Hesperidin; Male; Mice; Mice, Inbred ICR; Nucleolus Organizer Region; Precancerous Conditions; Silver Staining; Urinary Bladder Diseases; Urinary Bladder Neoplasms | 1997 |
Effects of oral administration of different doses of purified micronized flavonoid fraction on microvascular reactivity after ischaemia/reperfusion in the hamster cheek pouch.
Topics: Administration, Oral; Animals; Arterioles; Cheek; Cricetinae; Diosmin; Drug Combinations; Hesperidin; Ischemia; Male; Regional Blood Flow; Reperfusion; Venules | 1997 |
Effect of long-term treatment with a purified micronized flavonoid fraction on pancreatic mononuclear cell infiltration in diabetic BB rats.
Topics: Animals; C-Peptide; Chemotaxis, Leukocyte; Diabetes Mellitus, Type 1; Diosmin; Drug Combinations; Fibrinogen; Flavonoids; Fructosamine; Hesperidin; Islets of Langerhans; Leukocytes, Mononuclear; Male; Orosomucoid; Rats; Rats, Inbred BB | 1998 |
Effect of a micronized purified flavonoid fraction on in vivo platelet functions in the rat.
Topics: Animals; Collagen; Diosmin; Drug Combinations; Flavonoids; Hesperidin; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar | 1999 |
Leukocyte adhesion after oxidant challenge in the hamster cheek pouch microcirculation.
Topics: Animals; Antioxidants; Cell Adhesion; Cheek; Cricetinae; Diosmin; Drug Combinations; Hesperidin; Leukocytes; Male; Mesocricetus; Microcirculation; Oxidants; tert-Butylhydroperoxide; Vitamin E | 1999 |
Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diosmin; Female; Hesperidin; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
The inflammatory reaction during venous hypertension in the rat.
Topics: Animals; Antioxidants; CD18 Antigens; Cell Death; Cell Movement; Diosmin; Free Radicals; Hemorrhage; Hesperidin; Hypertension; Inflammation; Ischemia; L-Selectin; Leukocytes; Male; Mesentery; Microcirculation; Neutrophils; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Venous Insufficiency; Venules | 2000 |
Improved LC methods for the determination of diosmin and/or hesperidin in plant extracts and pharmaceutical formulations.
Topics: Chromatography, High Pressure Liquid; Diosmin; Hesperidin; Plant Extracts; Tablets | 2001 |
Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars.
Topics: Beverages; Chromatography, High Pressure Liquid; Citrus; Diosmin; Flavanones; Flavonoids; Fruit; Hesperidin; Sicily; Spectrometry, Mass, Electrospray Ionization | 2003 |
[The theory of lymphangion and current approaches to the pathogenesis, diagnosis and treatment of lymphedema of the lower extremities].
Topics: Animals; Biopsy; Diosmin; Drug Combinations; Electric Stimulation Therapy; Hesperidin; Humans; Leg; Lymphatic System; Lymphatic Vessels; Lymphedema; Lymphography | 2003 |
Simultaneous reversed-phase high-performance liquid chromatographic method for the determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical formulations.
Topics: Antioxidants; Beverages; Chromatography, High Pressure Liquid; Citrus; Diosmin; Flavanones; Flavonoids; Hesperidin; Indicators and Reagents; Reference Standards; Solutions; Spectrophotometry, Ultraviolet; Tablets | 2003 |
Metabolic fate of hesperidin, eriodictyol, homoeridictyol, and diosmin.
Topics: Diosmin; Flavanones; Flavones; Flavonoids; Hesperidin; Humans; Vitamins | 1958 |
Micronization enhances the protective effect of purified flavonoid fraction against postischaemic microvascular injury in the hamster cheek pouch.
Topics: Administration, Oral; Animals; Capillary Permeability; Cheek; Cricetinae; Diosmin; Drug Combinations; Hesperidin; Ischemia; Male; Mesocricetus; Microcirculation; Particle Size; Protective Agents; Regional Blood Flow; Reperfusion; Reperfusion Injury | 2004 |
[Risk factors of chronic venous insufficiency of the lower extremities and possibilities of its medication in therapeutic practice].
Topics: Adolescent; Adult; Age Factors; Aged; Bandages; Chronic Disease; Constipation; Diosmin; Drug Combinations; Exercise Therapy; Female; Hesperidin; Humans; Incidence; Leg; Male; Middle Aged; Obesity; Risk Factors; Sex Factors; Treatment Outcome; Venous Insufficiency | 2006 |
Effects of citrus flavonoids on redox homeostasis of toxin-injured liver in rat.
Topics: Animals; Citrus; Copper; Diosmin; Female; Flavonoids; Free Radical Scavengers; Hesperidin; Homeostasis; Iron; Liver; Manganese; Oxidation-Reduction; Rats; Rats, Wistar; Superoxide Dismutase; Thioacetamide; Zinc | 2006 |
[Immunological aspects of aphthous stomatitis].
Topics: Adolescent; Adult; Antigens, CD; Diosmin; Drug Combinations; Female; Hesperidin; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Interleukin-6; Male; Middle Aged; Stomatitis, Aphthous | 2007 |
Different flavonoids present in the micronized purified flavonoid fraction (Daflon 500 mg) contribute to its anti-hyperpermeability effect in the hamster cheek pouch microcirculation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Capillary Permeability; Cheek; Cricetinae; Diosmin; Drug Combinations; Drug Evaluation, Preclinical; Flavonoids; Glycosides; Hesperidin; Male; Microcirculation; Reperfusion Injury | 2008 |
[Certain aspects of pathogenesis of hemorheological and trophic disturbances and their pharmacological correction in patients with chronic venous insufficiency].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Blood Flow Velocity; Blood Viscosity; Chronic Disease; Diosmin; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Foot Ulcer; Glycosides; Hesperidin; Humans; Leg; Male; Middle Aged; Phlebography; Recurrence; Severity of Illness Index; Thrombophlebitis; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Duplex; Venous Insufficiency | 2008 |
Effects of purified micronized flavonoid fraction (Detralex) on prophylactic treatment of adjuvant arthritis with methotrexate in rats.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Bone Density; Diosmin; Drug Combinations; Edema; Hesperidin; Male; Methotrexate; Nitrates; Nitrites; Plethysmography; Rats; Serum Albumin; Severity of Illness Index | 2008 |
Effects of calcium dobesilate and diosmin-hesperidin on apoptosis of venous wall in primary varicose veins.
Topics: Adult; Aged; Apoptosis; bcl-2-Associated X Protein; Calcium Dobesilate; Cardiovascular Agents; Diosmin; Drug Combinations; Female; Hesperidin; Humans; Male; Middle Aged; Preoperative Care; Proto-Oncogene Proteins c-bcl-2; Saphenous Vein; Treatment Outcome; Tumor Suppressor Protein p53; Varicose Veins | 2008 |
The phytochemical analysis and antioxidant activity assessment of orange peel (Citrus sinensis) cultivated in Greece-Crete indicates a new commercial source of hesperidin.
Topics: Antioxidants; Biphenyl Compounds; Chromatography, Liquid; Citrus sinensis; Diosmin; Flavanones; Greece; Hesperidin; Luminescent Measurements; Luminol; Methanol; Models, Chemical; Picrates; Plant Extracts; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2009 |
Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.
Topics: Diosmin; Drug Stability; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Hesperidin; Humans; Linear Models; Male; Oxidation-Reduction; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Treatment of rat adjuvant arthritis with flavonoid (Detralex), methotrexate, and their combination.
Topics: Animals; Arthritis, Experimental; Diosmin; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Hesperidin; Hindlimb; Immunosuppressive Agents; Male; Methotrexate; Nitrates; Nitrites; Rats; Rats, Inbred Lew; Serum Albumin; Treatment Outcome | 2009 |
[Conservative treatment of patients with varicose esophagus veins cirrhosis].
Topics: Adult; Aged; Diosmin; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Hesperidin; Humans; Liver Cirrhosis; Male; Middle Aged; Severity of Illness Index; Time Factors | 2010 |
HPLC determination of hesperidin, diosmin and eriocitrin in Iranian lime juice using polyamide as an adsorbent for solid phase extraction.
Topics: Acetic Acid; Acetonitriles; Adsorption; Beverages; Chromatography, High Pressure Liquid; Citrus aurantiifolia; Diosmin; Flavanones; Hesperidin; Hydrogen-Ion Concentration; Iran; Methanol; Nylons; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Water | 2011 |
The effects of doxycycline and micronized purified flavonoid fraction on human vein wall remodeling are not hypoxia-inducible factor pathway-dependent.
Topics: Adult; Aged; Anti-Bacterial Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Diosmin; Doxycycline; Female; Hesperidin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Middle Aged; Saphenous Vein; Signal Transduction; Tissue Culture Techniques; Varicose Veins | 2012 |
Effects of diosmine-hesperidine on experimental colonic anastomosis.
Topics: Anastomosis, Surgical; Animals; Colon; Diosmin; Drug Combinations; Female; Hesperidin; Hydroxyproline; Rats; Rats, Wistar; Tensile Strength; Wound Healing | 2012 |
Impact of micronised purified flavonoid fraction on increased malondialdehyde and decreased metalloproteinase-2 and metalloproteinase-9 levels in varicocele: outcome of an experimentally induced varicocele.
Topics: Animals; Diosmin; Flavonoids; Hesperidin; Male; Malondialdehyde; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats; Rats, Wistar; Testis; Tissue Inhibitor of Metalloproteinase-1; Varicocele | 2014 |
[Phlebotrophic therapy with venarus in patients suffering from lower limb chronic venous insufficiency].
Topics: Adult; Chronic Disease; Compression Bandages; Diosmin; Drug Combinations; Female; Follow-Up Studies; Hesperidin; Humans; Lower Extremity; Male; Middle Aged; Quality of Life; Retrospective Studies; Treatment Outcome; Venous Insufficiency | 2013 |
A flavonoid fraction purified from Rutaceae aurantiae (Daflon(R)) inhibiting AGE formation, reduces urinary albumin clearance and corrects hypoalbuminemia in normotensive and hypertensive diabetic rats.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diosmin; Flavonoids; Fructosamine; Glomerular Basement Membrane; Glycation End Products, Advanced; Hesperidin; Hyperglycemia; Hypoalbuminemia; Kidney Glomerulus; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Rats, Inbred SHR; Rats, Wistar; Rutaceae | 2014 |
[Ultrasound assessment of alterations in venous haemodynamics in patients with post-thrombotic disease permanently taking phlebotonics].
Topics: Acute Disease; Adult; Anticoagulants; Combined Modality Therapy; Compression Bandages; Diosmin; Drug Combinations; Drug Monitoring; Female; Follow-Up Studies; Hemodynamics; Hesperidin; Humans; Lower Extremity; Male; Middle Aged; Treatment Outcome; Ultrasonography, Doppler, Duplex; Vasoconstrictor Agents; Veins; Venous Insufficiency; Venous Thrombosis | 2014 |
[Ultrasound elastography in assessing efficacy of treatment for lower limb varicose veins with a phlebotrophic drug containing a micronized purified flavonoid fraction].
Topics: Biological Availability; Diosmin; Drug Combinations; Drug Monitoring; Elasticity; Elasticity Imaging Techniques; Feasibility Studies; Female; Flavonoids; Hesperidin; Humans; Lower Extremity; Male; Middle Aged; Phlebitis; Saphenous Vein; Severity of Illness Index; Treatment Outcome; Varicose Veins; Venous Insufficiency | 2014 |
[Application of rivaroxabane in patients with proteins C and S deficiency].
Topics: Adult; Anticoagulants; Blood Coagulation; Diosmin; Drug Combinations; Drug Monitoring; Female; Hesperidin; Humans; Male; Morpholines; Protein C Deficiency; Protein S Deficiency; Rivaroxaban; Thiophenes; Time; Treatment Outcome; Venous Thrombosis | 2014 |
Effects of Citrus Flavonoids Against Microvascular Damage Induced by Hypoperfusion and Reperfusion in Rat Pial Circulation.
Topics: Animals; Apigenin; Arterioles; Citrus; Diosmin; Hesperidin; Male; Microcirculation; Nitric Oxide Synthase; Rats; Rats, Wistar; Reperfusion; Vasodilation | 2015 |
[Chronic venous disorders - necessity of specific differentiation to determination of the best medical treatment].
Topics: Diosmin; Hesperidin; Humans; Lymphedema; Varicose Ulcer; Venous Insufficiency | 2015 |
[Recommendations of the Polish Gynecological Society expert panel on the use of Detramax in pregnancy].
Topics: Diosmin; Female; Gynecology; Hesperidin; Humans; Inservice Training; National Health Programs; Obstetrics; Plant Leaves; Poland; Pregnancy; Pregnancy Complications, Cardiovascular; Proanthocyanidins; Quality Assurance, Health Care; Societies, Medical; Venous Thrombosis; Vitis; Women's Health | 2015 |
[VARICOSE DISEASE OF THE LOWER EXTREMITIES: CAUSES, COMPLICATIONS, CHOICE OF METHODS FOR TREATMENT AND PROPHYLAXIS].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angioplasty; Antioxidants; Diosmin; Disease Management; Drug Combinations; Female; Heme; Hesperidin; Humans; Lower Extremity; Male; Middle Aged; Retrospective Studies; Saphenous Vein; Sclerotherapy; Severity of Illness Index; Silicones; Sorption Detoxification; Treatment Outcome; Varicose Veins; Venous Insufficiency | 2016 |
[Transitory (evening) venous reflux in patients with intracutaneous varicosity and medicamentous correction thereof].
Topics: Adult; Cardiovascular Agents; Diosmin; Drug Combinations; Female; Flavonoids; Hesperidin; Humans; Lower Extremity; Quality of Life; Russia; Severity of Illness Index; Telangiectasis; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Duplex; Varicose Veins | 2016 |
Use of multiresponse statistical techniques to optimize the separation of diosmin, hesperidin, diosmetin and hesperitin in different pharmaceutical preparations by high performance liquid chromatography with UV-DAD.
Topics: Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Diosmin; Flavonoids; Hesperidin; Pharmaceutical Preparations; Solid Phase Microextraction; Ultraviolet Rays | 2017 |
A comparative study of Mentha arvensis L. and Mentha haplocalyx Briq. by HPLC.
Topics: Chromatography, High Pressure Liquid; Cinnamates; Depsides; Diosmin; Flavonoids; Glycosides; Hesperidin; Mentha; Rosmarinic Acid; Species Specificity | 2018 |
Protective Effects of Micronized Purified Flavonoid Fraction (MPFF) on a Novel Experimental Model of Chronic Venous Hypertension.
Topics: Animals; Capillary Permeability; Cricetinae; Diosmin; Disease Models, Animal; Drug Evaluation, Preclinical; Flavonoids; Glycosides; Hesperidin; Hypertension; Iliac Vein; Male; Microcirculation; Reperfusion Injury | 2018 |
Administration of Micronized Purified Flavonoid Fraction During Sclerotherapy of Reticular Veins and Telangiectasias: Results of the National, Multicenter, Observational Program VEIN ACT PROLONGED-C1.
Topics: Administration, Oral; Adult; Chronic Disease; Diosmin; Drug Combinations; Edema; Female; Flavonoids; Hesperidin; Humans; Male; Middle Aged; Pain; Pre-Exposure Prophylaxis; Quality of Life; Sclerotherapy; Surveys and Questionnaires; Telangiectasis; Treatment Outcome | 2018 |
Hyaluronan as a mediator for the hepatoprotective effect of Diosmin/Hesperidin complex.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Diosmin; Drug Combinations; Gamma Rays; Hesperidin; Hyaluronic Acid; Liver; Liver Function Tests; Male; Radiation Injuries, Experimental; Rats; Whole-Body Irradiation | 2018 |
Conservative Treatment of Hemorrhoids: Results of an Observational Multicenter Study.
Topics: Adult; Chronic Disease; Conservative Treatment; Diosmin; Drug Combinations; Female; Flavonoids; Hemorrhage; Hemorrhoids; Hesperidin; Humans; Male; Middle Aged; Russia; Secondary Prevention; Severity of Illness Index; Symptom Assessment; Treatment Outcome | 2018 |
NIR spectroscopy-multivariate analysis for discrimination and bioactive compounds prediction of different Citrus species peels.
Topics: Citrus; Diosmin; Flavonoids; Fruit; Hesperidin; Least-Squares Analysis; Spectroscopy, Near-Infrared | 2019 |
A nutraceutical composition containing diosmin and hesperidin has osteogenic and anti-resorptive effects and expands the anabolic window of teriparatide.
Topics: Animals; Animals, Newborn; Bone Density; Bone Diseases, Metabolic; Bone Regeneration; Dietary Supplements; Diosmin; Female; Femur; Hesperidin; Osteogenesis; Rats, Sprague-Dawley; Teriparatide; Tibia | 2019 |
Development of an on-line lab-on-valve micro-solid phase extraction system coupled to liquid chromatography for the determination of flavonoids in citrus juices.
Topics: Chromatography, High Pressure Liquid; Citrus; Diosmin; Fruit and Vegetable Juices; Hesperidin; History, 21st Century; Limit of Detection; Reproducibility of Results; Solid Phase Microextraction | 2019 |
Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats.
Topics: Acrylamide; Animals; Antioxidants; Biomarkers; Brain; Catalase; Creatinine; Diosmin; DNA Damage; Glutathione; Glutathione Peroxidase; Hazardous Substances; Hesperidin; Kidney; Lipid Peroxidation; Liver; Male; Malondialdehyde; Oxidative Stress; Protective Agents; Rats; Rats, Wistar; Superoxide Dismutase | 2019 |
Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?
Topics: Angiotensin-Converting Enzyme 2; Anticoagulants; Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome; Diosmin; Drug Therapy, Combination; Heparin; Hesperidin; Humans; MAP Kinase Signaling System; Pandemics; Phytotherapy; Receptors, Virus; SARS-CoV-2; Venous Thromboembolism; Virus Internalization | 2020 |
Diosmin/hesperidin: a cooperating tandem, or is diosmin crucial and hesperidin an inactive ingredient only?
Topics: Chronic Disease; Diosmin; Flavonoids; Hesperidin; Humans; Vascular Diseases | 2020 |
Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells.
Topics: Ascorbic Acid; Calcium; Calcium Signaling; Cells, Cultured; Chalcones; Diosmin; Dose-Response Relationship, Drug; Drug Combinations; Gene Expression Regulation; Hesperidin; Humans; Lymphatic Vessels; Male; Middle Aged; Muscle Contraction; Myocytes, Smooth Muscle; Plant Extracts; Ruscus; Time Factors | 2022 |
Short-Term Effects of Supplemental L-Arginine, Diosmin, Troxerutin, and Hesperidin in Diabetic Patients: A Pilot Study.
Topics: Antioxidants; Apolipoprotein A-I; Apolipoprotein B-100; Arginine; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Diosmin; Endothelium, Vascular; Female; Hesperidin; Humans; Hydroxyethylrutoside; Male; Middle Aged; Oxidative Stress; Pilot Projects; Prospective Studies | 2021 |
Impact of drying methods on natural antioxidants, phenols and flavanones of immature dropped Citrus sinensis L. Osbeck fruits.
Topics: Antioxidants; Citrus; Citrus sinensis; Diosmin; Flavanones; Flavonoids; Fruit; Hesperidin; Phenols; Plant Extracts | 2022 |
Selected polyphenolic compounds and their use as a supportive therapy in metabolic syndrome.
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Antioxidants; Child; Diosmin; Hesperidin; Humans; Metabolic Syndrome; Quercetin; Silybin | 2022 |
Comparison of the effects of methylprednisolone, hyperbaric oxygen and hesperidin + diosmin on the facial nerve injury: an experimental animal model.
Topics: Animals; Diosmin; Facial Nerve; Facial Nerve Injuries; Hesperidin; Hyperbaric Oxygenation; Methylprednisolone; Models, Animal; Nerve Regeneration; Rats | 2023 |