hesperetin has been researched along with hesperidin in 509 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (0.98) | 18.7374 |
| 1990's | 15 (2.95) | 18.2507 |
| 2000's | 86 (16.90) | 29.6817 |
| 2010's | 285 (55.99) | 24.3611 |
| 2020's | 118 (23.18) | 2.80 |
| Authors | Studies |
|---|---|
| Ash, K; Grohmann, K; Manthey, CL; Manthey, JA; Montanari, A | 1 |
| Bailey, DG; Dawson, PA; Dresser, GK; Freeman, DJ; Kim, RB; Leake, BF; Schwarz, UI | 1 |
| Bronze, MR; Mendes, T; Serra, H; Simplício, AL | 1 |
| Amić, D; Lucić, B | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Bijak, M; Krotkiewski, H; Nowak, P; Pawlaczyk, I; Ponczek, M; Saluk, J; Wachowicz, B; Ziewiecki, R | 1 |
| Han, C; Kong, L; Lei, J; Li, S; Liu, C; Peng, W; Wang, Z; Xu, X | 1 |
| Cubo, MT; Downie, JA; Economou, A; Johnston, AW; Murphy, G | 1 |
| Chauvaux, N; De Greef, J; John, M; Prinsen, E; Schell, J; Schmidt, J; Van Onckelen, H; Wieneke, U | 1 |
| 'T Hart, BA; Ip Via Ching, TR; Labadie, RP; Van Dijk, H | 1 |
| Guengerich, FP; Kim, DH | 1 |
| Downie, JA; Economou, A; Hamilton, WD; Surin, BP; Watson, JM | 1 |
| Downie, JA; Economou, A; Hawkins, FK; Johnston, AW | 1 |
| Kaul, TN; Middleton, E; Ogra, PL | 1 |
| Kroyer, G | 1 |
| Middleton, E; Vladutiu, GD | 1 |
| Bonina, F; Castelli, F; Lanza, M; Marzullo, D; Saija, A; Scalese, M | 1 |
| Das, NP; Kuppusamy, UR | 1 |
| Hans, B; Kramarczyk, R; Krumbiegel, G; Rickling, B; Weyhenmeyer, R | 1 |
| Liehr, JG; Zhu, BT | 1 |
| Chiang, CH; Chiou, GC; Liu, SX; Yao, QS | 1 |
| Carroll, KK; Chambers, AF; Guthrie, N; Moussa, M; So, FV | 1 |
| Balentine, DA; Conney, AH; Loder, DP; Taneja, N; Zhu, BT | 1 |
| Borradaile, NM; Carroll, KK; Kurowska, EM | 1 |
| Choudhury, R; Chowrimootoo, G; Debnam, ES; Rice-Evans, C; Spencer, JP; Srai, SK | 1 |
| Burke, MD; Doostdar, H; Mayer, RT | 1 |
| Johnson, MK; Loo, G | 1 |
| Alfthan, G; Aro, A; Erlund, I; Meririnne, E | 1 |
| Ji, HT; Qian, DH; Wang, JS; Zhang, JP; Zhang, M | 1 |
| Borradaile, NM; de Dreu, LE; Huff, MW; Wilcox, LJ | 1 |
| Tobias, CA; Yang, TC | 1 |
| Anno, T; Cha, JY; Cho, YS; Kim, I; Rahman, SM; Yanagita, T | 1 |
| Chovanec, P; Kropácová, M; Lisá, L; Nemcová, M; Novák, K; Skrdleta, V | 1 |
| Aromaa, A; Hakulinen, T; Heliövaara, M; Järvinen, R; Knekt, P; Kumpulainen, J; Reunanen, A; Rissanen, H | 1 |
| Alfthan, G; Aro, A; Erlund, I; Kesäniemi, YA; Rantala, M; Silaste, ML | 1 |
| Fujisaw, S; Ishihara, M; Kadoma, Y | 1 |
| Choi, MS; Jeong, TS; Kim, HK; Lee, MK; Park, YB | 1 |
| Alzuru, M; Mendez, J; Paredes, A; Rodríguez-Ortega, M | 1 |
| Abbott, NJ; Dobbie, MS; Kuhnle, G; Proteggente, AR; Rice-Evans, C; Youdim, KA | 1 |
| Chen, FM; Li, ZC; Zhou, YJ | 1 |
| Duh, PD; Huang, SL; Tsai, HL; Yen, GC | 1 |
| Bok, SH; Jeong, TS; Kim, EE; Lee, CH; Lee, S; Lee, WS; Moon, SS; Oh, GT; Oh, JH | 1 |
| Chen, YC; Lin, HY; Shen, SC | 2 |
| de la Rocha, NE; Guardia, T; Juárez, AO; Pelzer, LE; Rotelli, AE | 1 |
| Basu-Modak, S; Gordon, MJ; Kuhnle, G; Proteggente, AR; Rice-Evans, CA; Tyrrell, R; Youdim, K | 1 |
| Georgarakis, M; Kanaze, FI; Kokkalou, E; Niopas, I | 1 |
| Arcas, MC; Baidez, AG; Botía, JM; del Río, JA; Gómez, P; Ortuño, A | 1 |
| Lu, Y; Wu, C; Yuan, Z | 1 |
| Choi, SH; Kim, DH; Lee, NK; Park, EK; Park, SH | 1 |
| Choi, JS; Chung, HY; Jung, KJ; Kim, JY | 2 |
| Benjamin, MM; Gallard, H; Korshin, GV; Lu, J | 1 |
| Erb, A; Kraus, M; Labib, S; Richling, E; Wickert, T | 1 |
| Daugherty, A; Kurowska, EM; Manthey, JA; Whitman, SC | 1 |
| Alvarez, E; Basaran, H; Lugnier, C; Orallo, F | 1 |
| Davies, NM; Roupe, KA; Teng, XW; Yáñez, JA | 1 |
| Wang, YD; Xie, MX; Xu, XY | 1 |
| Liu, F; Peng, Y; Ye, J; Yuan, J | 1 |
| Choi, YJ; Jeong, YJ; Kang, SW; Kang, YH; Kwon, HM; Lee, M; Park, HS | 1 |
| Besson, C; Manach, C; Mathevon, T; Morand, C; Remesy, C; Scalbert, A; Silberberg, M | 1 |
| Calabrò, ML; Catania, S; Costa, C; Donato, P; Ficarra, P; Ficarra, R; Stancanelli, R; Tommasini, S; Villari, V | 1 |
| Chao, PD; Ho, TY; Hsieh, CC; Lai, CC; Lin, CW; Tsai, CH; Tsai, FJ; Wan, L | 1 |
| Huong, DT; Ide, T; Takahashi, Y | 1 |
| Dimpfel, W | 1 |
| Fukumoto, S; Hiramitsu, M; Kondo, K; Miyake, Y; Osawa, T; Sakaida, K; Sakurai, C; Usuda, M | 1 |
| Chee, KM; Choi, EJ; Kim, GD; Kim, GH | 1 |
| Pollard, SE; Spencer, JP; Whiteman, M | 1 |
| Bauer, A; Greten, J; Karle, CA; Kathöfer, S; Katus, HA; Kiesecker, C; Kreuzer, J; Remppis, A; Scholz, EP; Thomas, D; Zitron, E | 1 |
| Cho, J | 1 |
| Bounartzi, MI; Georgarakis, M; Kanaze, FI; Niopas, I | 1 |
| Chung, JH; Han, XH; Jin, YR; Lee, JJ; Lim, Y; Yun, YP; Zhang, YH | 1 |
| Jung, S; Kwon, C; Park, H | 1 |
| Gardana, C; Guarnieri, S; Porrini, M; Riso, P; Simonetti, P | 1 |
| Jing, Y; Liang, XM; Xu, Q; Xue, XY; Zhang, FF; Zhou, DY | 1 |
| Choi, EM; Kim, YH | 1 |
| Choi, EJ | 2 |
| Han, XH; Jin, YR; Kim, TJ; Lee, JJ; Lim, Y; Yoo, HS; Yun, YP; Zhang, YH | 1 |
| Kobayashi, S; Konishi, Y; Sugiyama, M; Tanabe, S | 1 |
| Bennett, RN; Bisignano, G; Faulds, CB; Gasson, MJ; Mandalari, G; Narbad, A; Saija, A; Trombetta, D | 1 |
| Andrews, PK; Davies, NM; Miranda, ND; Remsberg, CM; Vega-Villa, KR; Yáñez, JA | 1 |
| Hamada, H; Shimoda, K | 2 |
| Cheng, YY; Liu, L; Xu, DM | 1 |
| Bhatnagar, A; Kaiserova, K; Srivastava, S; Tang, XL | 1 |
| Lien, TF; Su, WT; Yeh, HS | 1 |
| Liu, Y; Song, R; Tian, Y; Xu, F; Zhang, Z | 1 |
| Hase, T; Suzuki, A; Yamamoto, M | 1 |
| Bourland, TC; Miller, EG; Patil, BS; Peacock, JJ; Taylor, SE; Wright, JM | 1 |
| Bahia, P; Fahmi, A; Rainey-Smith, S; Rattray, M; Rice-Evans, C; Schroetke, LW; Skilton, R; Spencer, JP; Williams, RJ | 1 |
| Barron, D; Brand, W; Rein, MJ; Rietjens, IM; van Bladeren, PJ; van der Wel, PA; Williamson, G | 1 |
| Davis, JW; Holland, LJ; Manthey, JA; Morin, B; Nichols, LA; Zalasky, KM | 1 |
| Aranganathan, S; Nalini, N; Panneer Selvam, J | 1 |
| Cheng, YY; Liu, L; Lu, XP; Ning, ZQ; Shan, S; Zhang, K | 1 |
| Aranganathan, S; Nalini, N; Selvam, JP | 1 |
| Kasmas, S; Niopas, I; Spanakis, M | 1 |
| Jung, S; Kwon, C; Paik, SR | 1 |
| Hanada, H; Handa, K; Hirota, K; Mochizuki, H; Morikawa, K; Nonaka, M | 1 |
| Denny, BJ; Mathew, TC; West, PW | 1 |
| Barreca, D; Bellocco, E; Ficarra, S; Galtieri, A; Kotyk, A; Laganà, G; Leuzzi, U; Tellone, E | 1 |
| Ahn, WS; Choi, EJ | 1 |
| Al Shaal, L; Keck, CM; Mishra, PR; Müller, RH | 2 |
| Chen, G; Chen, Y; Huang, C; Zhou, T | 1 |
| Huang, XY; Song, B; Zeng, YY; Zhou, YY | 1 |
| Coxam, V; Davicco, MJ; Demigne, C; Habauzit, V; Horcajada, MN; Lebecque, P; Mercier, S; Trzeciakiewicz, A | 1 |
| Lee, HY; Rodriguez-Mateos, A; Spencer, JP; Vafeiadou, K; Vauzour, D; Williams, RJ | 1 |
| Aranganathan, S; Nalini, N; Sangeetha, N; Selvam, JP | 1 |
| De Luca, G; Di Donna, L; Mazzotti, F; Napoli, A; Salerno, R; Sindona, G; Taverna, D | 1 |
| Li, Y; Wang, MF; Yang, ZY | 1 |
| Maiti, K; Mukherjee, K; Mukherjee, PK; Murugan, V; Saha, BP | 1 |
| Aranganathan, S; Nalini, N | 2 |
| Barmpalexis, P; Bikiaris, D; Georgarakis, E; Kanaze, FI; Kokkalou, E; Niopas, I | 1 |
| Aturki, Z; Badjah-Hadj-Ahmed, AY; D'Orazio, G; Fanali, S; Rocco, A; Si-Ahmed, K; Tazerouti, F | 1 |
| Fang, F; Huang, Z; Wang, J; Wong, CW | 1 |
| Barron, D; Habauzit, V; Horcajada, MN; Manach, C; Mercier, S; Offord, E; Trzeciakiewicz, A; Urpi-Sarda, M | 1 |
| Barron, D; Bik, H; Boersma, MG; Brand, W; Glatt, H; Hoek-van den Hil, EF; Meinl, W; Rietjens, IM; van Bladeren, PJ; Vervoort, J; Williamson, G | 1 |
| Huang, CT; Huang, YB; Lee, KF; Tsai, YH; Wu, PC | 2 |
| Barron, D; Bouisset, F; Bredsdorff, L; Cornett, C; Nielsen, IL; Offord, E; Rasmussen, SE; Williamson, G | 1 |
| Brand, W; Padilla, B; Rietjens, IM; van Bladeren, PJ; Williamson, G | 1 |
| Bredsdorff, L; Haraldsdóttir, J; Knuthsen, P; Krogholm, KS; Rasmussen, SE | 1 |
| Cao, H; Chen, X; Lv, H; Sakurai, T; Sun, H; Sun, W; Wang, X; Zhou, J | 1 |
| Al Shaal, L; Keck, CM; Müller, RH | 1 |
| Kai, H; Kawai, K; Ogata, K; Shuto, T; Takamura, N; Tokunaga, J; Yoshida, H | 1 |
| Breccia, JD; Mazzaferro, L; Minig, M; Piñuel, L | 1 |
| Boza, J; Cerdá, B; Escudero, E; Espín, JC; García-Conesa, MT; Larrosa, M; Tomás-Barberán, FA; Vallejo, F; Zafrilla, MP | 1 |
| Brand, W; de Haan, LH; Dionisi, F; Hoek-van den Hil, EF; Rein, MJ; Rietjens, IM; Shao, J; Spenkelink, B; van Bladeren, PJ; van Elk, KN; Williamson, G | 1 |
| Creczynski-Pasa, T; Jaramillo, C; Lima, VR; Londoño-Londoño, J | 1 |
| Dong, H; Liu, Y; Song, R; Xu, F; Zhang, Z | 1 |
| Choi, EM; Lee, YS | 1 |
| Cho, YY; Choi, MS; Jeon, SM; Kim, HJ; Kwon, EY; Lee, JH; Lee, MK | 1 |
| Cai, L; Li, J; Li, R; Peng, L; Xie, XF | 1 |
| Dube, V; Joseph, SK; Lakshmi, V; Mishra, SK; Murthy, PK; Sahoo, MK; Srivastava, S; Verma, SK | 1 |
| Fu, H; Fujii, K; Hata, K; Katsumura, Y; Lin, M; Muroya, Y; Shikazono, N; Yokoya, A | 1 |
| Hadjmohammadi, MR; Nazari, SS | 1 |
| Bortolozzo, S; Floreani, M; Moro, S; Nassi, A; Palatini, P; Pavanetto, M; Quintieri, L; Stragliotto, S | 1 |
| Han, SB; Jin, MJ; Kim, DH; Kim, IS; Kim, U; Kim, Y; Kwon, OS; Yoo, HH | 1 |
| Pari, L; Shagirtha, K | 2 |
| Hegde, AH; Sandhya, B; Seetharamappa, J | 1 |
| Choi, EJ; Kim, GH | 1 |
| Jena, GB; Tripathi, DN; Trivedi, PP | 1 |
| Holland, LJ; Jackson, DE; Manthey, JA; Nichols, LA; Shukla, SD | 1 |
| Chen, H; Kunnimalaiyaan, M; Pinchot, SN; Zarebczan, B | 1 |
| Hwang, SL; Yen, GC | 1 |
| Jena, GB; Kushwaha, S; Tripathi, DN; Trivedi, PP | 1 |
| Arai, T; Hamashima, Y; Hasegawa, J; Kajimoto, T; Node, M; Suzuki, N; Tanaka, R; Tokuda, H; Tsujii, H; Yamada, T | 1 |
| Chebib, M; Loscalzo, LM; Marder, M; Wasowski, C; Yow, TT | 1 |
| Catania, S; Costa, C; Melchini, A; Stancanelli, R; Tommasini, S | 1 |
| Leung, LK; Li, F; Lin, SM; Ye, L | 1 |
| Floreani, M; Moro, S; Palatini, P; Quintieri, L | 1 |
| Hussein, SZ; Makpol, S; Yusof, YA; Yusoff, KM | 1 |
| Ishiduka, S; Kometani, T; Mukai, R; Takumi, H; Terao, J | 1 |
| Herath, W; Khan, IA | 1 |
| Actis-Goretta, L; Dionisi, F; Giuffrida, F; Lévèques, A; Rein, MJ; Williamson, G | 1 |
| Breadmore, MC; Li, Y; Lu, Y; Yao, Q; Zhong, H | 1 |
| Kalist, S; Leelavinothan, P | 1 |
| Bi, K; Gao, J; Sun, H; Tong, L; Zhou, D; Zhu, Y | 1 |
| Barron, D; Brand, W; Dionisi, F; Krajcsi, P; Oosterhuis, B; Rietjens, IM; van Bladeren, PJ; Williamson, G | 1 |
| Chung, HY; Park, D; Park, YD; Qian, GY; Si, YX; Wang, SF; Wang, ZJ; Yan, L; Yang, JM; Yin, SJ | 1 |
| Chen, SC; Hou, YC; Hseu, YC; Lee Chao, PD; Senthil Kumar, KJ; Tsai, SY; Yang, HL; Yu, KN | 1 |
| Akbarsha, MA; Bernini, R; Menon, VP; Nalini, N; Preethy, CP; Riyasdeen, A; Sivagami, G; Vinothkumar, R | 1 |
| Abubakar, S; Mustafa, MR; Sam, SS; Teoh, BT; Wong, PF; Zandi, K | 1 |
| Chan, FL; Chen, S; Leung, LK; Ye, L | 1 |
| Hwang, SL; Shih, PH; Yen, GC | 1 |
| Hippalgaonkar, K; Majumdar, S; Srirangam, R | 1 |
| Chiou, YL; Huang, YC; Liu, KC | 1 |
| Harada, R; Kawai, Y; Kometani, T; Mukai, R; Murota, K; Nadamoto, T; Nakamura, H; Simizu, T; Takumi, H; Terao, J | 1 |
| Bi, S; Pang, B; Wang, T; Wang, Y; Yan, L | 1 |
| Hegde, AH; Prashanth, SN; Seetharamappa, J | 1 |
| Huang, SM; Lin, JA; Tsai, SY; Wu, CH; Yen, GC | 1 |
| Aranganathan, S; Kabalimurthy, J; Nalini, N | 1 |
| Bae, JT; Kim, GB; Ko, HJ; Lee, GS; Pyo, HB | 1 |
| Iinuma, M; Iio, A; Ito, M; Nozawa, Y; Ohguchi, K | 1 |
| Ishihara, S; Matsuura, A; Qi, J; Sakagami, Y; Sun, K; Xiang, L | 1 |
| Barraj, LM; Bi, X; Cheatham, R; Herman, D; Murphy, MM; Randolph, RK | 1 |
| Hwang, SL; Lin, JA; Shih, PH; Yeh, CT; Yen, GC | 1 |
| Avula, B; Hippalgaonkar, K; Khan, IA; Majumdar, S; Srirangam, R | 1 |
| Iinuma, M; Masuda, M; Matsuda, H; Murata, K; Takano, S | 1 |
| Alshatwi, AA; Periasamy, VS; Ramesh, E; Subash-Babu, P | 1 |
| Li, D; Mitsuhashi, S; Ubukata, M | 1 |
| Cai, L; Li, J; Li, R; Peng, L; Wu, TN; Xie, XF | 1 |
| Boom, K; Fang, X; Ferrari, M; Shen, H; Wolfram, J; Yang, Y | 1 |
| Furtado, AF; Nunes, MA; Ribeiro, MH | 1 |
| Raza, MA; Shahwar, D | 1 |
| Dong, T; Han, Y; Sakurai, T; Sun, H; Wang, X; Wu, X; Yan, G; Yang, J; Zhang, A | 1 |
| Fang, X; Ferrari, M; Shen, H; Wolfram, J; Yang, Y | 1 |
| Konrad, M; Mohr, F; Oberwinkler, J; Philipp, SE; Schaefer, M; Stab, J; Straub, I | 1 |
| Ferruzzi, MG; Jouni, ZE; Song, BJ | 1 |
| Chan, FL; Chen, S; Cheung, WH; Chow, S; Leung, LK; Li, F | 1 |
| Jia, W; Tang, L | 1 |
| Bennetau-Pelissero, C; Bérard, AM; Chanet, A; Claude, S; Kamran Khan, M; Maier, JA; Mazur, A; Milenkovic, D; Morand, C; Rakotomanomana, N; Shinkaruk, S | 1 |
| Alfaro, FF; Cappellini, C; Céliz, G; Daz, M; Verstraeten, SV | 1 |
| Gupta, SK; Jha, KA; Kumar, B; Nag, TC; Saxena, R; Srinivasan, BP; Srivastava, S | 1 |
| Huang, C; Huang, Y; Li, HY; Li, J; Li, R; Li, RQ; Ren, DY; Xu, T | 1 |
| Bian, Z; Cheng, Z; Deng, W; Fang, Y; Jiang, D; Lin, Y; Liu, Y; Pu, P; Tang, Q; Zhang, J; Zhang, R; Zhou, H | 1 |
| Heo, JS; Kang, KL; Kim, SY; Lee, JC; Lee, JY; Park, YD | 1 |
| Naveen Babu, K; Ravindra Babu, P; Sridhar, V; Surya Sandeep, M | 1 |
| Ito, A; Norimoto, H; Okubo, T; Shin, N; Tsuchida, T | 1 |
| Anandan, B; Chandra, SR; Jayaraman, G; Malathi, R; Paramasivam, A; Radha, M; Sambantham, S | 1 |
| Asghari, A; Barfi, A; Barfi, B; Rajabi, M; Saeidi, I | 1 |
| Breccia, JD; Guisán, JM; López-Gallego, F; Piñuel, L | 1 |
| Ahn, DU; Kim, KT; Lee, JH; Moon, SH; Nah, SY; Paik, HD; Park, YS | 1 |
| Bansal, AK; Khomane, KS; Shete, G | 1 |
| Nam, HK; Oh, DK; Shin, KC | 1 |
| Bracht, A; Constantin, J; Constantin, RP; Ishii-Iwamoto, EL; Yamamoto, NS | 1 |
| Bracht, A; Constantin, J; Constantin, RP; do Nascimento, GS; Ishii-Iwamoto, EL; Salgueiro, CL; Yamamoto, NS | 1 |
| Hase, T; Jokura, H; Shimotoyodome, A; Suzuki, A; Yamamoto, M | 1 |
| Chen, H; Jaskula-Sztul, R; Patel, PN; Yu, XM | 1 |
| Bian, Z; Dai, J; Deng, W; Li, F; Liu, Y; Tang, Q; Wu, Q; Yang, Z; Yuan, Y; Zhou, H | 1 |
| Arikan, S; Ersan, I; Gencer, B; Hanci, V; Kara, S; Karaboga, I; Karaca, T; Tufan, HA | 1 |
| Avery, MA; Boulos, N; Gilbertson, R; Guy, RK; Jacob, MR; Jeffries, C; Khan, IA; Li, XC; Liang, Q; Ravu, RR; Shelat, AA; Smithson, D; Tu, Y; Walker, LA; Wang, M; Wu, Y; Yang, J | 1 |
| Fordham, JB; Naqvi, AR; Nares, S | 1 |
| Abd-Alla, MH; Bagy, MK; Bashandy, SR; El-enany, AW | 1 |
| Cui, L; Hou, X; Li, J; Liu, Y; Niu, L; Zhang, M; Zhang, X | 1 |
| Gamo, K; Matsuura, N; Miyachi, H; Shiraki, T | 1 |
| Cakir Gungor, AN; Cosar, E; Demirtas, S; Gencer, M; Hacivelioglu, S; Karaca, T; Korkmaz, F; Uysal, A | 1 |
| Aswar, M; Aswar, U; Kute, P; Mahajan, S; Mahajan, U; Nerurkar, G | 1 |
| Grigorova-Borsos, AM; Guillot, R; Jacolot, P; Kassab, I; Peyroux, J; Sternberg, M; Tessier, F; Urios, P | 1 |
| Gamo, K; Matsuura, N; Miyachi, H; Nakamura, K | 1 |
| Iranshahi, M; Parhiz, H; Rezaee, R; Roohbakhsh, A; Soltani, F | 4 |
| Borrego, F; Tomás-Barberán, FA; Tomás-Navarro, M; Vallejo, F | 1 |
| Das, PK; Kar, S; Palit, S; Sharma, G | 1 |
| Feng, F; Liu, XY | 1 |
| Alshatwi, AA; Subash-Babu, P | 1 |
| Chen, CY; Chiu, YW; Lin, CC; Lin, YJ; Yang, CH | 1 |
| Iqbal, Z; Kumar, V; Negi, LM; Singh, P; Talegaonkar, S; Tyagi, A; Verma, AK; Zafar, S | 1 |
| Brodowska, K; Bujacz, A; Chruscinski, L; Cieslak, M; Garribba, E; Janicka, M; Klewicka, E; Krolewska, K; Lodyga-Chruscinska, E; Oldziej, S; Rowinska-Zyrek, M; Sykula, A; Symonowicz, M | 1 |
| Deng, W; Jiao, R; Li, L; Liu, W; Liu, Y; Tang, Q | 1 |
| Borges, G; Calani, L; Clifford, MN; Crozier, A; Del Rio, D; Ky, I; Pereira-Caro, G; Ribas, A; Roberts, SA | 1 |
| Ansarin, K; Kolahian, S; Pour Moghaddam, M; Sakhinia, E; Sakhinia, M; Seyedrezazadeh, E; Shahbazfar, AA; Vafa, M | 1 |
| Ding, F; Peng, W | 1 |
| Li, C; Schluesener, H | 1 |
| Aksit, H; Demirtas, I; Elmastas, M; Erenler, R; Sen, O; Telci, İ; Yaglioglu, AS | 1 |
| Adelli, GR; Balguri, SP; Hingorani, T; Majumdar, S; Punyamurthula, N | 1 |
| Dong, W; Song, J; Wang, J; Wu, D; Zhang, J | 1 |
| Magraner-Pardo, L; Peris, JE; Taléns-Visconti, R; Usach, I | 1 |
| Bansal, AK; Jain, S; Pawar, YB; Shete, G; Thanki, K | 1 |
| Bedel, A; Bennetau-Pelissero, C; Bérard, AM; Constans, J; Martin, JF; Mazur, A; Morand, C; Rock, E | 1 |
| Cassidy, A; Franke, AA; Hu, FB; Pan, A; Rimm, EB; Sun, Q; Townsend, MK; Tworoger, SS; van Dam, RM; Wedick, NM | 1 |
| Chen, J; Huang, S; Li, K; Shao, H; Zhao, L; Zhou, H | 1 |
| Gurushankar, K; Jayasree, RS; Krishnakumar, N; Nazeer, SS | 1 |
| Dong, W; Song, J; Wang, J; Wu, D; Yi, J; Zhang, J | 1 |
| Agrawal, S; Ahmad, H; Arya, A; Dwivedi, AK; Khandelwal, K; Khatik, R; Mittapelly, N; Singh, A | 1 |
| Adan, A; Baran, Y | 2 |
| Bansal, AK; Modi, SR; Shete, G | 1 |
| Chen, R; Chen, Z; Hu, C; Hu, T; Huang, C; Li, J; Li, Y; Meng, X; Qian, Z; Shen, C | 2 |
| Lu, D; Ma, Z; Sun, H; Wang, X; Wu, B; Zhou, X | 1 |
| Bando, M; Nakazawa, Y; Oka, M; Takehana, M | 1 |
| Fan, G; Song, F; Wu, F; Ye, X | 1 |
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| Uchiyama, H | 1 |
| Duarte, D; Silva-Lima, B; Sousa, C; Videira, M | 1 |
| Long, WY; Wu, Y; Zhao, GH | 1 |
| Yu, Z; Zhang, X | 1 |
| Duan, X; Duan, Z; Ge, Y; Lu, X; Rao, L; Wen, Y; Xu, J; Xu, L; Xue, T; Zhu, Y | 1 |
| Abd Elkader, HAE; Abdou, HM | 1 |
| Güzel, EE; Tektemur, A; Tektemur, NK | 1 |
| Chi, X; Jiang, H; Jin, H; Pang, Y; Sun, Y; Wu, F; Zhang, J; Zhang, S | 1 |
| Bu, FT; Huang, C; Jia, P; Li, J; Li, JJ; Lu, XY; Wang, A; Zhang, YL; Zhu, L | 1 |
| Kishi, H; Kobayashi, S; Lu, Q; Morita, T; Zhang, Y | 1 |
| Dzeikala, A; Garribba, E; Klewicka, E; Kręgiel, D; Piekarska-Radzik, L; Sykuła, A; Łodyga-Chruścińska, E | 1 |
| Chen, Z; Huang, S; Lian, P; Lin, Z; Long, C; Long, L; Luo, G; Shen, J; Wu, J; Zhong, G | 1 |
| Huang, X; Liu, J; Shan, Y; Tian, M; Wang, Z; Xiao, F | 1 |
| Lai, MC; Liou, SS; Liu, IM; Liu, WY | 1 |
| Adebimpe, MO; Elekofehinti, OO; I Umar, H; Lawal, AO; Olumegbon, LT; Oluyede, DM | 1 |
| Rabbani, N; Thornalley, PJ | 1 |
| Caballero, S; Davidov-Pardo, G; Li, YO; McClements, DJ | 1 |
| Abdou, HM; Ali, EY; Ghoneum, MH; Hamaad, FA | 1 |
| Alam, W; Efferth, T; Hussain, Y; Khan, H | 1 |
| Cielecka-Piontek, J; Płazińska, A; Płaziński, W; Rosiak, N; Tykarska, E; Wdowiak, K; Żarowski, M | 1 |
| Ghasemnejad-Berenji, M; Khezri, MR; Moloodsouri, D | 1 |
| Islam, J; Khan, HA; Shree, A; Sultana, S; Yadav, V | 1 |
| Bellini, MZ; Buchaim, DV; Buchaim, RL; de Marchi, MÂ; Detregiachi, CRP; Fideles, SOM; Flato, UAP; Gardizani, TP; Ortiz, AC; Pagani, BT; Pereira, ESBM; Pilon, JPG; Ponce, JB; Reis, CHB; Trazzi, BFM; Veronez, FS | 1 |
| Evans, JA; Mendonca, P; Soliman, KFA | 1 |
| Chen, SY; Chen, X; Cheng, M; Huang, C; Li, J; Li, XF; Wang, A; Wu, S; Wu, YY; Xu, JJ; Zhu, S | 1 |
| de Albuquerque-Júnior, RLC; de Araújo Andrade, T; de Araujo, GRS; de Souza Araujo, AA; de Souza Siqueira Quintans, J; Dos Santos, DM; Dos Santos, MRV; Dos Santos-Neto, AG; Frank, LA; Heimfarth, L; Lira, AAM; Matos, SS; Quintans-Júnior, LJ; Rabelo, TK; Serafini, MR | 1 |
| Anbalagan, M; Gor, R; Kesavan, Y; Lazer, LM; Narayan, S; Pathak, S; Ramachandran, I; Ramalingam, S | 1 |
| Idrees, M; Joo, MD; Khan, AM; Kong, IK; Kumar, V; Lee, KW; Uddin, Z | 1 |
| Cheng, M; Huang, C; Li, J; Niu, XN; Shi, W; Wu, YY; Yang, YL; Yin, NN; Zhang, YL; Zhu, L | 1 |
| Fang, H; Gong, J; Lin, Y; Ren, J; Su, D; Tang, L; Wang, Y; Xu, S; Yang, H | 1 |
| Bazan-Woźniak, A; Cielecka-Piontek, J; Pietrzak, R; Walkowiak, J; Wdowiak, K | 1 |
| Cheng, Y; Fan, L; Li, Y; Lu, Q; Lu, Z; Luan, X; Luo, D; Xia, Q; Zeng, N | 1 |
| Kao, CH; Lu, CK; Shen, ZQ; Teng, YC; Tsai, TF; Wang, TW; Yeh, CH; Yeh, TK | 1 |
| Bernroider, M; Chen, L; Feng, GW; Genser, J; Hierlmeier, G; Hu, XX; Lan, YJ; Leitner, C; Li, H; Lin, DF; Lyu, KY; Meng, L; Neubauer, F; Qu, X; Shen, T; Sun, RC; Wang, C; Weng, SF; Wolf, R; Xu, QY; Yang, SX; Yao, ZM; Zhang, LZ; Zhang, M; Zhang, NX; Zhang, X; Zhu, DX; Zhu, JJ; Zhu, S | 1 |
| Eltelbany, RFA; Khalil, HMA; Rasheed, RA; Zaafar, D; Zaitone, SA | 1 |
| Bakhtiyari, M; Nabi-Afjadi, M; Rostampour, P; Shapourian, H; Tavakol, C; Zalpoor, H | 1 |
| Hodaei, M; Varshosaz, J | 1 |
| Chakraborty, R; El-Sherbiny, M; Eladl, MA; Elsherbini, DMA; Famurewa, AC; Goutam Mukherjee, A; Madhyastha, H; Myakala, H; Ramesh Wanjari, U; Renu, K; Valsala Gopalakrishnan, A; Vellingiri, B | 1 |
| Amirinejad, M; Badiee, A; Davoodi, J; Gheybi, F; Omidfar, F | 1 |
| Arjsri, P; Dejkriengkraikul, P; Mapoung, S; Semmarath, W; Srisawad, K; Thippraphan, P; Umsumarng, S; Yodkeeree, S | 1 |
| Endo, H; Sakusa, K; Tanaka, M; Yano, M | 1 |
| Cao, Z; Chen, C; Chen, G; Lei, H; Lu, Y; Song, Y; Wu, F; Zhang, C; Zhang, L; Zhou, J | 1 |
| Bae, J; Fujimura, Y; Fujino, K; Kumazoe, M; Marugame, Y; Nezu, A; Tachibana, H; Yoshimoto, T | 1 |
| Aghazadeh, M; Alipour, M; Dizaj, SM; Samiei, M; Shahi, S; Sharifi, S | 1 |
| Bojarová, P; Brodsky, K; Franková, J; Hanyk, J; Křen, V; Novotná, R; Škařupová, D; Ulrichová, J; Vostálová, J | 1 |
| Chen, P; Chen, S; Gao, Q; Mao, S; Ren, Y; Tian, J; Wu, J; Ye, X; Yu, D | 1 |
| Amanlou, M; Khorsand, B; Rostamabadi, H; Samandari-Bahraseman, MR; Zareei, S | 1 |
| Cui, Z; Li, L; Liu, F; Lu, F; Qu, L; Wang, W | 1 |
23 review(s) available for hesperetin and hesperidin
| Article | Year |
|---|---|
Neuroprotective effects of citrus flavonoids.
Topics: Antioxidants; Blood-Brain Barrier; Citrus; Diet; Flavonoids; Fruit; Hesperidin; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Signal Transduction | 2012 |
Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin--a mini-review.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Citrus; Cytochrome P-450 Enzyme System; Hesperidin; Humans; Learning; Memory; Signal Transduction; Terfenadine | 2014 |
Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Citrus; Disease Models, Animal; Hesperidin; Humans; Inflammation; NF-kappa B; Oxidative Stress; Signal Transduction | 2015 |
Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiovascular Diseases; Citrus; Free Radical Scavengers; Hesperidin; Humans; Neoplasms | 2015 |
Health-promoting effects of the citrus flavanone hesperidin.
Topics: Anti-Inflammatory Agents; Antioxidants; Carcinoma; Cardiovascular Diseases; Citrus; Drug Combinations; Hesperidin; Humans; Nervous System Diseases; Randomized Controlled Trials as Topic | 2017 |
Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin.
Topics: Animals; Anti-Infective Agents; Hesperidin; Humans; Models, Biological; Protective Agents | 2015 |
The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Citrus; Hesperidin; Humans; Neoplasms; Signal Transduction | 2015 |
Effects of Plants on Osteogenic Differentiation and Mineralization of Periodontal Ligament Cells: A Systematic Review.
Topics: Aloe; Cell Differentiation; Cell Proliferation; Centella; Coumarins; Epimedium; Flavonoids; Hesperidin; Humans; Mannans; Morinda; Osteogenesis; Periodontal Ligament; Plant Extracts; Triterpenes; Zanthoxylum | 2016 |
Flavanones: Citrus phytochemical with health-promoting properties.
Topics: Animals; Antioxidants; Citrus; Flavanones; Flavonoids; Hesperidin; Humans; Oxidative Stress | 2017 |
Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Citrus; Hesperidin; Humans; Neoplasms | 2020 |
Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies.
Topics: Animals; Antioxidants; Citrus; Diabetes Mellitus; Disaccharides; Flavanones; Flavones; Flavonoids; Glycosides; Hesperidin; Humans; Inflammation; Phytochemicals; Polyphenols; Propiophenones | 2020 |
Hesperetin's health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations.
Topics: Antioxidants; Biological Availability; Citrus; Flavonoids; Hesperidin | 2022 |
Topics: Adult; Alcohol Drinking; Ammonia; Animals; Anti-Inflammatory Agents; Area Under Curve; B-Lymphocytes; Black or African American; Bleaching Agents; Body Mass Index; Brugada Syndrome; Carbon; China; Climate Models; Codon, Nonsense; Cohort Studies; Colitis; Colon; COVID-19; Cytokines; Dental Enamel; Dextran Sulfate; Disease Models, Animal; Disease Outbreaks; Dogs; Electrocardiography; Escherichia coli; Esophageal Neoplasms; Female; Follow-Up Studies; Forests; Georgia; Glucosides; Healthy Volunteers; Heart Ventricles; Hesperidin; HIV Infections; Humans; Humidity; Hydrogen Peroxide; Incidence; Influenza, Human; Longitudinal Studies; Magnetic Resonance Imaging, Cine; Male; Melanocortins; Mice; Mice, Inbred C57BL; Microscopy, Electron, Scanning; Middle Aged; Muscular Dystrophy, Duchenne; Naphthol AS D Esterase; Naphthols; Neoplasms; Nitrates; Nitrites; Nitrous Oxide; Obesity; Pandemics; Patient Outcome Assessment; Patient Satisfaction; Plants; Prednisolone; Prednisone; Pregnenediones; Proportional Hazards Models; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Rats; Receptor, Melanocortin, Type 1; Retrospective Studies; Risk Factors; SARS-CoV-2; Seasons; Soil; Stroke Volume; T-Lymphocytes; Telemedicine; Temperature; Tetralogy of Fallot; Tooth Bleaching; Tooth Bleaching Agents; Trees; Urea; White People | 2021 |
[Construction of Coamorphous Technology Aimed at Improving Membrane Permeability and Application to Emulsion].
Topics: Biological Availability; Cell Membrane Permeability; Crystallization; Drug Design; Drug Stability; Emulsions; Flavanones; Hesperidin; Oils; Phase Transition; Solubility; Temperature; Water | 2021 |
Repurposing Natural Dietary Flavonoids in the Modulation of Cancer Tumorigenesis: Decrypting the Molecular Targets of Naringenin, Hesperetin and Myricetin.
Topics: Carcinogenesis; Flavanones; Flavonoids; Hesperidin; Humans; Neoplasms; NF-kappa B; Phosphatidylinositol 3-Kinases | 2022 |
Emerging Glycation-Based Therapeutics-Glyoxalase 1 Inducers and Glyoxalase 1 Inhibitors.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Enzyme Induction; Glutathione; Glycosylation; Hesperidin; Humans; Insulin Resistance; Lactoylglutathione Lyase; Mice; Molecular Structure; Neoplasms, Experimental; Obesity; Pyruvaldehyde; Resveratrol | 2022 |
Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Endoplasmic Reticulum Stress; Hesperidin; Rats | 2022 |
Therapeutic Effects of Citrus Flavonoids Neohesperidin, Hesperidin and Its Aglycone, Hesperetin on Bone Health.
Topics: Bone Density; Citrus; Flavanones; Flavonoids; Hesperidin; Osteoporosis | 2022 |
Neuroprotective Effects and Therapeutic Potential of the Citrus Flavonoid Hesperetin in Neurodegenerative Diseases.
Topics: Anti-Inflammatory Agents; Citrus; Flavonoids; Hesperidin; Humans; Neurodegenerative Diseases; Neuroprotective Agents | 2022 |
Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review.
Topics: Antioxidants; Citrus; Diabetes Mellitus; Hesperidin | 2022 |
Bioavailability of Hesperidin and Its Aglycone Hesperetin-Compounds Found in Citrus Fruits as a Parameter Conditioning the Pro-Health Potential (Neuroprotective and Antidiabetic Activity)-Mini-Review.
Topics: Biological Availability; Citrus; Hesperidin; Hypoglycemic Agents | 2022 |
Hesperetin as an anti-SARS-CoV-2 agent can inhibit COVID-19-associated cancer progression by suppressing intracellular signaling pathways.
Topics: COVID-19 Drug Treatment; Hesperidin; Humans; Neoplasms; SARS-CoV-2; Signal Transduction | 2022 |
Hesperidin and hesperetin against heavy metal toxicity: Insight on the molecular mechanism of mitigation.
Topics: Animals; Arsenic; Cadmium; Chromium; Hesperidin; Humans; Lead; Mercury; Metals, Heavy | 2022 |
15 trial(s) available for hesperetin and hesperidin
| Article | Year |
|---|---|
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.
Topics: Administration, Oral; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Beverages; Biological Availability; Carrier Proteins; Citrus; Double-Blind Method; Female; Flavonoids; Food-Drug Interactions; Fruit; HeLa Cells; Histamine H1 Antagonists; Humans; Intestinal Absorption; Male; Malus; Membrane Transport Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Symporters; Terfenadine | 2002 |
Two high-performance liquid chromatographic assays for the determination of free and total silibinin diastereomers in plasma using column switching with electrochemical detection and reversed-phase chromatography with ultraviolet detection.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Flavonoids; Hesperidin; Humans; Hydrolysis; Male; Middle Aged; Silymarin; Spectrophotometry, Ultraviolet; Stereoisomerism | 1995 |
Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables.
Topics: Adult; Biomarkers; Cross-Over Studies; Feeding Behavior; Female; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Middle Aged; Quercetin; Reference Values; Time Factors; Vegetables | 2002 |
Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects.
Topics: Beverages; Biological Availability; Citrus sinensis; Cross-Over Studies; Disaccharides; Double-Blind Method; Female; Flavanones; Fruit; Glucosides; Glycoside Hydrolases; Hesperidin; Humans; Male; Placebos | 2010 |
Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.
Topics: Adult; Area Under Curve; Biological Availability; Diet; Flavanones; Hesperidin; Humans; Male; Quercetin; Young Adult | 2010 |
Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Blood Circulation; Body Temperature; Female; Hesperidin; Human Umbilical Vein Endothelial Cells; Humans; Male; Middle Aged; Vasodilation; Vasodilator Agents; Young Adult | 2012 |
Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men.
Topics: Antioxidants; Apolipoprotein A-I; Ascorbic Acid; Biomarkers; Body Mass Index; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Citrus sinensis; Cross-Over Studies; Flavonoids; Fruit and Vegetable Juices; Hesperidin; Humans; Hypercholesterolemia; Male; Middle Aged; Oxidative Stress; Phytochemicals; Reactive Oxygen Species; Risk Factors; Single-Blind Method; Triglycerides | 2015 |
Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Glucose; Cell Line; Cross-Over Studies; Female; Glutathione; Glutathione Disulfide; Hep G2 Cells; Hesperidin; Humans; Lactoylglutathione Lyase; Male; Middle Aged; Models, Biological; Obesity; Overweight; Pyruvaldehyde; Resveratrol; Stilbenes; Young Adult | 2016 |
Urinary excretion of Citrus flavanones and their major catabolites after consumption of fresh oranges and pasteurized orange juice: A randomized cross-over study.
Topics: Adult; Biological Availability; Citrus sinensis; Cross-Over Studies; Dose-Response Relationship, Drug; Flavanones; Food Analysis; Fruit; Fruit and Vegetable Juices; Hesperidin; Hippurates; Humans; Pasteurization; Tandem Mass Spectrometry; Young Adult | 2016 |
Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes.
Topics: Athletes; Biological Availability; Chromatography, High Pressure Liquid; Citrus sinensis; Colon; Diet; Exercise; Flavanones; Fruit; Fruit and Vegetable Juices; Glucuronides; Hesperidin; Humans; Male; Mass Spectrometry; Oxygen Consumption; Physical Endurance; Plant Extracts; Polyphenols; Rest; Sports | 2017 |
A Critical Evaluation of In Vitro Hesperidin 2S Bioavailability in a Model Combining Luminal (Microbial) Digestion and Caco-2 Cell Absorption in Comparison to a Randomized Controlled Human Trial.
Topics: Antioxidants; Caco-2 Cells; Cinnamates; Citrus sinensis; Colon; Dietary Supplements; Digestion; Double-Blind Method; Female; Flavonoids; Fruit; Gastrointestinal Microbiome; Glucuronides; Hesperidin; Humans; Hydrolysis; Intestinal Absorption; Kinetics; Male; Models, Biological; Plant Extracts; Surface Properties | 2018 |
Hesperetin protects crayfish Procambarus clarkii against white spot syndrome virus infection.
Topics: Animal Feed; Animals; Astacoidea; Diet; Dietary Supplements; Dose-Response Relationship, Drug; Hesperidin; Immunity, Innate; Longevity; Virus Replication; White spot syndrome virus 1 | 2019 |
The efficacy and safety of an antiaging topical serum containing hesperetin and sodium cyclic lysophosphatidic acid: A single-center clinical trial.
Topics: Female; Hesperidin; Humans; Lysophospholipids; Skin; Skin Aging; Sodium | 2021 |
Reversal of Insulin Resistance in Overweight and Obese Subjects by
Topics: Adult; Blood Pressure; Body Mass Index; Carrier Proteins; Correlation of Data; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Female; Glucose Metabolism Disorders; Glycosylation; Hesperidin; Humans; Inflammation; Inflammation Mediators; Insulin Resistance; Leukocytes, Mononuclear; Male; Obesity; Overweight; Pyruvaldehyde; Resveratrol; Tumor Necrosis Factor-alpha | 2021 |
Concomitant use of tea catechins affects absorption and serum triglyceride-lowering effects of monoglucosyl hesperidin.
Topics: Adult; Beverages; Catechin; Cross-Over Studies; Double-Blind Method; Female; Glucosides; Hesperidin; Humans; Male; Middle Aged; Single-Blind Method; Tea; Triglycerides | 2021 |
471 other study(ies) available for hesperetin and hesperidin
| Article | Year |
|---|---|
Polymethoxylated flavones derived from citrus suppress tumor necrosis factor-alpha expression by human monocytes.
Topics: Citrus; Cyclic AMP; Flavonoids; Humans; In Vitro Techniques; Lipopolysaccharides; Monocytes; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 1999 |
Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.
Topics: Caco-2 Cells; Electrophoresis, Capillary; Flavanones; Flavones; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Molecular Structure; Molecular Weight | 2008 |
Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.
Topics: Flavonoids; Free Radical Scavengers; Models, Biological; Quantitative Structure-Activity Relationship; Quantum Theory; Software; Thermodynamics | 2010 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Thrombin inhibitory activity of some polyphenolic compounds.
Topics: | 2014 |
Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Flavones; Histone Demethylases; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Structure-Activity Relationship | 2019 |
Molecular characterization and regulation of the rhizosphere-expressed genes rhiABCR that can influence nodulation by Rhizobium leguminosarum biovar viciae.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; DNA-Binding Proteins; Flavonoids; Gene Expression Regulation, Bacterial; Hesperidin; Molecular Sequence Data; Operon; Plasmids; Recombinant Fusion Proteins; Rhizobium leguminosarum; Sequence Alignment; Trans-Activators | 1992 |
Stimulation of indole-3-acetic acid production in Rhizobium by flavonoids.
Topics: Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Gene Expression Regulation, Bacterial; Hesperidin; Indoleacetic Acids; Isoflavones; Kinetics; Luteolin; Rhizobium | 1991 |
How flavonoids inhibit the generation of luminol-dependent chemiluminescence by activated human neutrophils.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Calcimycin; Flavanones; Flavonoids; Flavonols; Hesperidin; Humans; Luminescent Measurements; Luminol; Luteolin; Neutrophils; Oxygen; Peroxidase; Pyridazines; Quercetin; Superoxides; Tetradecanoylphorbol Acetate; Xanthine Oxidase | 1990 |
In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids.
Topics: Aflatoxins; Chamomile; Chromatography, High Pressure Liquid; Dihydropyridines; Felodipine; Flavanones; Flavins; Flavonoids; Gene Expression Regulation; Hesperidin; Humans; In Vitro Techniques; Kaempferols; Microsomes, Liver; Oils, Volatile; Plants, Medicinal; Quercetin; Transcriptional Activation | 1990 |
Molecular characterization of the nodulation gene, nodT, from two biovars of Rhizobium leguminosarum.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Flavonoids; Gene Expression Regulation, Bacterial; Genes, Bacterial; Hesperidin; Molecular Sequence Data; Mutation; Operon; Phenotype; Rhizobium | 1990 |
Transcription of rhiA, a gene on a Rhizobium leguminosarum bv. viciae Sym plasmid, requires rhiR and is repressed by flavanoids that induce nod genes.
Topics: Bacterial Proteins; Chamomile; Flavonoids; Gene Expression Regulation; Genes; Genes, Bacterial; Genes, Regulator; Hesperidin; Nitrogen Fixation; Oils, Volatile; Plants, Medicinal; Plasmids; Restriction Mapping; Rhizobium; Transcription, Genetic | 1989 |
Antiviral effect of flavonoids on human viruses.
Topics: Animals; Catechin; Cell Line; Flavanones; Flavonoids; Hesperidin; Humans; Parainfluenza Virus 3, Human; Poliovirus; Quercetin; Respiratory Syncytial Viruses; Simplexvirus; Viral Plaque Assay; Virus Physiological Phenomena; Virus Replication; Viruses | 1985 |
[The antioxidant activity of citrus fruit peels].
Topics: Antioxidants; Ascorbic Acid; Citrus; Flavanones; Flavonoids; Freeze Drying; Hesperidin; Vitamin E | 1986 |
Effects of flavonoids on enzyme secretion and endocytosis in normal and mucolipidosis II fibroblasts.
Topics: Acetylglucosaminidase; Biological Transport; Cells, Cultured; Endocytosis; Fibroblasts; Flavanones; Flavonoids; Hesperidin; Hexosaminidases; Humans; Mucolipidoses | 1986 |
Flavonoids as antioxidant agents: importance of their interaction with biomembranes.
Topics: Animals; Antioxidants; Brain; Calorimetry, Differential Scanning; Cell Membrane; Ferrous Compounds; Flavanones; Flavonoids; Hesperidin; Lipid Peroxidation; Liposomes; Male; Malondialdehyde; Oxidation-Reduction; Quercetin; Rats; Rats, Sprague-Dawley; Rutin; Thermodynamics; Thiobarbituric Acid Reactive Substances | 1995 |
Antilipolytic action of hesperetin in rat adipocytes.
Topics: Adipocytes; Animals; Carbohydrate Sequence; Flavonoids; Hesperidin; In Vitro Techniques; Insulin; Lipolysis; Male; Molecular Sequence Data; Rats; Rats, Wistar | 1993 |
Inhibition of catechol O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by quercetin. Possible role in estradiol-induced tumorigenesis.
Topics: Animals; Catechol O-Methyltransferase Inhibitors; Cricetinae; Enzyme Inhibitors; Estradiol; Estrogens, Catechol; Flavonoids; Flavonols; Hesperidin; Kidney; Kidney Neoplasms; Kinetics; Male; Mesocricetus; Methylation; Oxidation-Reduction; Quercetin; S-Adenosylhomocysteine | 1996 |
Increase of ocular blood flow by some phytogenic compounds.
Topics: Acetophenones; Administration, Topical; Animals; Anticoagulants; Antioxidants; Coumarins; Eye; Flavonoids; Hesperidin; Microspheres; Mydriatics; p-Hydroxyamphetamine; Rabbits; Regional Blood Flow; Reserpine | 1996 |
Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Beverages; Breast Neoplasms; Cell Division; Citrus; Female; Flavanones; Flavonoids; Genistein; Hesperidin; Humans; Isoflavones; Mammary Neoplasms, Experimental; Quercetin; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 1996 |
Effects of tea polyphenols and flavonoids on liver microsomal glucuronidation of estradiol and estrone.
Topics: Animals; Enzyme Inhibitors; Estradiol; Estrone; Female; Flavanones; Flavonoids; Glucuronates; Glucuronosyltransferase; Hesperidin; Kinetics; Mice; Mice, Inbred Strains; Microsomes, Liver; Nitrophenols; Phenols; Polymers; Rats; Rats, Inbred Strains; Tea; Uridine Diphosphate Glucuronic Acid | 1998 |
Regulation of HepG2 cell apolipoprotein B metabolism by the citrus flavanones hesperetin and naringenin.
Topics: Apolipoproteins B; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Flavanones; Flavonoids; Hesperidin; Humans; Leupeptins; Multienzyme Complexes; Proteasome Endopeptidase Complex; Tumor Cells, Cultured | 1999 |
The small intestine can both absorb and glucuronidate luminal flavonoids.
Topics: Animals; Caffeic Acids; Chlorogenic Acid; Coumaric Acids; Flavonoids; Glucuronates; Hesperidin; Ileum; In Vitro Techniques; Intestinal Absorption; Jejunum; Kaempferols; Male; Perfusion; Propionates; Quercetin; Rats; Rats, Sprague-Dawley; Rutin | 1999 |
Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1.
Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Flavonoids; Hesperidin; Humans; Kinetics; Microsomes, Liver | 2000 |
Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA.
Topics: Antioxidants; Bepridil; Biphenyl Compounds; Catechin; Comet Assay; DNA; DNA Damage; Flavanones; Flavonoids; Free Radical Scavengers; Genistein; Hesperidin; Humans; Indicators and Reagents; Isoflavones; Jurkat Cells; Molsidomine; Nitric Oxide Donors; Oxidation-Reduction; Picrates; Quercetin | 2000 |
Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice.
Topics: Adult; Antioxidants; Area Under Curve; Beverages; Biological Availability; Biomarkers; Chromatography, High Pressure Liquid; Citrus; Diet; Estrogen Antagonists; Female; Flavanones; Flavonoids; Hesperidin; Humans; Intestinal Absorption; Male; Metabolic Clearance Rate; Urinalysis | 2001 |
Effect of six flavonoids on proliferation of hepatic stellate cells in vitro.
Topics: Animals; Cell Division; Cells, Cultured; Culture Media, Conditioned; Female; Flavonoids; Flavonols; Hesperidin; Kupffer Cells; Mice; Mice, Inbred ICR; Platelet-Derived Growth Factor; Quercetin | 2000 |
Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP.
Topics: Anticholesteremic Agents; Apolipoproteins B; Carcinoma, Hepatocellular; Carrier Proteins; Cholesterol; Cholesterol Esters; Citrus; Enzyme-Linked Immunosorbent Assay; Flavanones; Flavonoids; Hepatocytes; Hesperidin; Humans; Receptors, LDL; Sterol O-Acyltransferase; Sterol O-Acyltransferase 2; Triglycerides; Tumor Cells, Cultured | 2001 |
Effects of heavy ion radiation on the brain vascular system and embryonic development.
Topics: Abnormalities, Radiation-Induced; Animals; Animals, Newborn; Brain; Cerebral Hemorrhage; Cerebrovascular Circulation; Dose-Response Relationship, Radiation; Embryo, Mammalian; Female; Flavonoids; Hesperidin; Iron; Linear Energy Transfer; Mice; Neon; Pregnancy; Radiation, Ionizing; Rats; Rats, Inbred F344; Relative Biological Effectiveness; X-Rays | 1984 |
Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats.
Topics: Animals; Cholesterol; Diet; Fatty Acids; Flavonoids; Glucosephosphate Dehydrogenase; Hesperidin; Liver; Malate Dehydrogenase; Male; Microsomes, Liver; Orotic Acid; Phosphatidate Phosphatase; Rats; Rats, Sprague-Dawley; Triglycerides | 2001 |
Effect of exogenous flavonoids on nodulation of pea (Pisum sativum L.).
Topics: beta-Galactosidase; Flavanones; Flavonoids; Hesperidin; Hydroponics; Nitrogenase; Pisum sativum; Plant Roots; Quercetin; Rhizobium leguminosarum; Symbiosis | 2002 |
Flavonoid intake and risk of chronic diseases.
Topics: Adult; Arthritis, Rheumatoid; Asthma; Cataract; Cerebrovascular Disorders; Chronic Disease; Diabetes Mellitus, Type 2; Diet; Female; Flavanones; Flavonoids; Hesperidin; Humans; Kaempferols; Lung Neoplasms; Male; Middle Aged; Mortality; Myocardial Ischemia; Neoplasms; Prostatic Neoplasms; Quercetin; Risk; Risk Factors; Surveys and Questionnaires | 2002 |
Kinetic evaluation of the reactivity of flavonoids as radical scavengers.
Topics: Catechin; Flavonoids; Free Radical Scavengers; Free Radicals; Hesperidin; Kinetics; Molecular Structure; Polymers; Propyl Gallate; Quercetin; Resveratrol; Stilbenes; Structure-Activity Relationship | 2002 |
Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats.
Topics: Animals; Caffeic Acids; Cholesterol; Cholesterol, Dietary; Coumaric Acids; Hesperidin; Hydroxymethylglutaryl CoA Reductases; Lipids; Male; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase; Triglycerides | 2003 |
Anti-Sindbis activity of flavanones hesperetin and naringenin.
Topics: Animals; Antiviral Agents; Cricetinae; Flavanones; Flavonoids; Hesperidin; Sindbis Virus | 2003 |
Interaction between flavonoids and the blood-brain barrier: in vitro studies.
Topics: Animals; Anthocyanins; Blood-Brain Barrier; Brain; Cell Line; Chromatography, High Pressure Liquid; Coculture Techniques; Endothelium, Vascular; Flavanones; Flavonoids; Glioma; Glucuronides; Hesperidin; Mass Spectrometry; Mice; Microcirculation; Rats | 2003 |
[Prediction of eluotropic sequence of solutes in countercurrent chromatography].
Topics: Countercurrent Distribution; Hesperidin; Mathematics; Models, Chemical; Scopoletin; Solvents; Umbelliferones | 2002 |
Pro-oxidative properties of flavonoids in human lymphocytes.
Topics: Cell Survival; Deoxyribose; DNA Damage; Flavanones; Flavonoids; Hesperidin; Humans; Hydrogen Peroxide; Lymphocytes; Membrane Proteins; Oxidants; Oxidation-Reduction; Quercetin; Superoxides | 2003 |
Hypocholesterolemic activity of hesperetin derivatives.
Topics: Animals; Anticholesteremic Agents; Body Weight; Cholesterol; Cholesterol, Dietary; Ethers; Hesperidin; Hypercholesterolemia; Mice; Structure-Activity Relationship; Time Factors | 2003 |
Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids.
Topics: Apoptosis; beta-Glucosidase; Caspase 1; Caspase 3; Caspases; Drug Interactions; Flavanones; Flavonoids; Glycoside Hydrolases; Guanine Nucleotide Dissociation Inhibitors; Hesperidin; HL-60 Cells; Humans; Multienzyme Complexes; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neutrophils; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; rho Guanine Nucleotide Dissociation Inhibitor beta; rho-Specific Guanine Nucleotide Dissociation Inhibitors | 2003 |
Comparative study of flavonoids in experimental models of inflammation.
Topics: Animals; Arthritis, Experimental; Carrageenan; Disease Models, Animal; Ear; Edema; Flavonoids; Hesperidin; Hindlimb; Inflammation; Mice; Molecular Structure; Quercetin; Random Allocation; Rats; Rats, Wistar; Rutin; Xylenes | 2003 |
Hesperetin glucuronide, a photoprotective agent arising from flavonoid metabolism in human skin fibroblasts.
Topics: Cell Line; Chromatography, High Pressure Liquid; Fibroblasts; Flavonoids; Glucuronides; Hesperidin; Humans; Mass Spectrometry; Skin | 2003 |
Validated high-performance liquid chromatographic method utilizing solid-phase extraction for the simultaneous determination of naringenin and hesperetin in human plasma.
Topics: Chromatography, High Pressure Liquid; Citrus; Flavanones; Fruit; Hesperidin; Humans; Quality Control; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora.
Topics: Citrus sinensis; Flavanones; Flavonoids; Fruit; Fungicides, Industrial; Hesperidin; Phytophthora; Plant Diseases | 2004 |
Determination of hesperetin, cinnamic acid and nicotinic acid in propolis with micellar electrokinetic capillary chromatography.
Topics: Anti-Infective Agents; Chromatography, Micellar Electrokinetic Capillary; Cinnamates; Hesperidin; Humans; Hydrogen-Ion Concentration; Niacin; Phytotherapy; Propolis; Reproducibility of Results | 2004 |
Antiallergic activity of hesperidin is activated by intestinal microflora.
Topics: Animals; Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Line; Citrus; Dinoprostone; Free Radical Scavengers; Guinea Pigs; Hesperidin; Histamine Release; Humans; Hyaluronoglucosaminidase; In Vitro Techniques; Intestinal Mucosa; Intestines; Macrophages; Male; Mice; Mice, Inbred ICR; Nitric Oxide; Passive Cutaneous Anaphylaxis | 2004 |
Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Disaccharides; Drug Stability; Drug Synergism; Flavanones; Flavonoids; Glycosylation; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Hesperidin; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peritoneum; RNA Stability; RNA, Messenger; Teichoic Acids | 2005 |
Hesperetin: a potent antioxidant against peroxynitrite.
Topics: Animals; Antioxidants; Cell Line; Free Radical Scavengers; Hesperidin; Nitric Oxide; Peroxynitrous Acid; Rats; Reactive Oxygen Species; Serum Albumin, Bovine; Superoxides | 2004 |
Reactions of the flavonoid hesperetin with chlorine: a spectroscopic study of the reaction pathways.
Topics: Chlorine; Chromatography, High Pressure Liquid; Hesperidin; Hydrogen-Ion Concentration; Mass Spectrometry; Models, Chemical; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Water Purification | 2004 |
The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.
Topics: Animals; Cecum; Chromatography, High Pressure Liquid; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Hesperidin; Models, Animal; Quercetin; Spectrometry, Mass, Electrospray Ionization; Swine | 2004 |
Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.
Topics: Animals; Cell Membrane; Cells, Cultured; Citrus; Flavanones; Flavones; Fruit; Hesperidin; Lipoproteins, LDL; Lipoproteins, VLDL; Macrophages; Mice; Receptors, Immunologic; Receptors, Scavenger; Scavenger Receptors, Class A | 2005 |
Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Dose-Response Relationship, Drug; Free Radical Scavengers; Hesperidin; Male; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Superoxides; Vasodilation | 2004 |
Stereospecific high-performance liquid chromatographic analysis of hesperetin in biological matrices.
Topics: Administration, Oral; Adult; Animals; Chromatography, High Pressure Liquid; Hesperidin; Humans; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2005 |
Interaction between hesperetin and human serum albumin revealed by spectroscopic methods.
Topics: Hesperidin; Humans; Hydrogen-Ion Concentration; Protein Binding; Protein Conformation; Serum Albumin; Spectrum Analysis | 2005 |
Determination of active components in rosemary by capillary electrophoresis with electrochemical detection.
Topics: Antioxidants; Apigenin; Buffers; Caffeic Acids; Chromatography, High Pressure Liquid; Cinnamates; Coumaric Acids; Depsides; Electrochemistry; Electrodes; Electrophoresis, Capillary; Flavonoids; Hesperidin; Hydrogen-Ion Concentration; Ions; Luteolin; Models, Chemical; Plant Extracts; Regression Analysis; Rosmarinic Acid; Rosmarinus; Temperature; Time Factors | 2005 |
Differential inhibition of oxidized LDL-induced apoptosis in human endothelial cells treated with different flavonoids.
Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Catechin; Cells, Cultured; Copper; Endothelial Cells; Flavonoids; Gene Expression; Genes, bcl-2; Hesperidin; Humans; Lipoproteins, LDL; Proto-Oncogene Proteins c-bcl-2; Quercetin; Rutin; Thiobarbituric Acid Reactive Substances; Umbilical Veins | 2005 |
The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites.
Topics: Animals; Bile Ducts; Biological Availability; Chromatography, High Pressure Liquid; Coumaric Acids; Dose-Response Relationship, Drug; Flavonoids; Genistein; Hesperidin; Intestinal Absorption; Intestine, Small; Liver; Male; Molecular Structure; Perfusion; Phenols; Polyphenols; Rats; Rats, Wistar | 2006 |
The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-beta-cyclodextrin.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Chemistry, Pharmaceutical; Comet Assay; Drug Industry; Flavanones; Glucosides; Hesperidin; Hydroxyl Radical; Iron; Microscopy, Fluorescence; Models, Chemical; Oxygen; Protein Binding; Solubility; Spectrometry, Fluorescence; Spectrophotometry; Spectrophotometry, Ultraviolet; Time Factors; Ultraviolet Rays; Water | 2005 |
Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.
Topics: Animals; Anthraquinones; Chlorocebus aethiops; Coloring Agents; Coronavirus 3C Proteases; Cysteine Endopeptidases; Emodin; Endopeptidases; Enzyme Inhibitors; Glucosinolates; Hesperidin; Indigo Carmine; Indoles; Isatis; Phenols; Plant Extracts; Plant Roots; Vero Cells; Viral Proteins | 2005 |
Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids.
Topics: Animals; Fatty Acids; Flavanones; Gene Expression Regulation, Enzymologic; Hesperidin; Lipid Peroxidation; Liver; Male; Mice; Mice, Inbred ICR; Oxidation-Reduction; Peroxisomes; Random Allocation; RNA, Messenger; Up-Regulation | 2006 |
Different anticonvulsive effects of hesperidin and its aglycone hesperetin on electrical activity in the rat hippocampus in-vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Bicuculline; Convulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Hesperidin; Hippocampus; In Vitro Techniques; Male; Pentylenetetrazole; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tetraethylammonium | 2006 |
Difference in plasma metabolite concentration after ingestion of lemon flavonoids and their aglycones in humans.
Topics: Adult; Chromatography, High Pressure Liquid; Citrus; Flavanones; Flavones; Flavonoids; Fruit; Glucuronidase; Glycosides; Hesperidin; Humans; Kinetics; Male; Sulfatases | 2006 |
Effects of hesperetin on vessel structure formation in mouse embryonic stem (mES) cells.
Topics: Animals; Antioxidants; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Embryonic Stem Cells; Endothelial Cells; Free Radical Scavengers; Glutathione; Hesperidin; Immunohistochemistry; Mice; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species | 2006 |
Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling.
Topics: Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Hesperidin; Humans; Molsidomine; Nitric Oxide Donors; Peroxynitrous Acid; Signal Transduction; Tyrosine | 2006 |
Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656.
Topics: Amino Acids, Aromatic; Animals; Cardiovascular Diseases; Citrus sinensis; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Hesperidin; Mutation; Oocytes; Patch-Clamp Techniques; Potassium Channel Blockers; Xenopus | 2007 |
Modulation of the age-related nuclear factor-kappaB (NF-kappaB) pathway by hesperetin.
Topics: Aging; Animals; Cell Culture Techniques; Cell Line; Endothelial Cells; Epithelial Cells; Gene Expression Regulation; Genes, Reporter; Hesperidin; Humans; Kidney; Luciferases; Macrophages; Male; Mice; Molecular Structure; NF-kappa B; Rats; Rats, Inbred F344; Reactive Oxygen Species; Transcription, Genetic | 2006 |
Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin.
Topics: Animals; Antioxidants; Biphenyl Compounds; Cell Survival; Cell-Free System; Cells, Cultured; Cerebral Cortex; Free Radical Scavengers; Hesperidin; Lipid Peroxidation; Neurons; Neuroprotective Agents; Oxidative Stress; Picrates; Rats | 2006 |
Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Citrus; Dietary Supplements; Female; Flavanones; Hesperidin; Humans; Intestinal Absorption; Male | 2007 |
Antiplatelet activity of hesperetin, a bioflavonoid, is mainly mediated by inhibition of PLC-gamma2 phosphorylation and cyclooxygenase-1 activity.
Topics: Animals; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cyclooxygenase 1; Flavonoids; Hesperidin; Phospholipase C gamma; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin D2; Rabbits; Serotonin; Thromboxane-A Synthase | 2007 |
Enantioseparation of some chiral flavanones using microbial cyclic beta-(1-->3),(1-->6)-glucans as novel chiral additives in capillary electrophoresis.
Topics: beta-Glucans; Bradyrhizobium; Carbohydrate Sequence; Electrophoresis, Capillary; Flavanones; Flavones; Flavonoids; Hesperidin; Hydrogen-Ion Concentration; Molecular Sequence Data; Stereoisomerism | 2007 |
Flavanone plasma pharmacokinetics from blood orange juice in human subjects.
Topics: Adult; Antioxidants; Beverages; Chromatography, High Pressure Liquid; Citrus sinensis; Cross-Over Studies; Disaccharides; Estrogen Antagonists; Female; Flavanones; Hesperidin; Humans; Intestinal Absorption; Tandem Mass Spectrometry | 2007 |
Rapid qualitative and quantitative analyses of flavanone aglycones in Fructus aurantii by HPLC ion-trap MS.
Topics: Calibration; Chromatography, High Pressure Liquid; Citrus; Drugs, Chinese Herbal; Flavanones; Fruit; Hesperidin; Mass Spectrometry; Molecular Structure; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2007 |
Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation.
Topics: 3T3 Cells; Animals; Carbohydrates; Cell Differentiation; Hesperidin; Lipid Peroxidation; Mice; Osteoblasts | 2008 |
Hesperetin induced G1-phase cell cycle arrest in human breast cancer MCF-7 cells: involvement of CDK4 and p21.
Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Female; G1 Phase; Hesperidin; Humans; Time Factors | 2007 |
Hesperetin, a bioflavonoid, inhibits rat aortic vascular smooth muscle cells proliferation by arresting cell cycle.
Topics: Animals; Aorta; Becaplermin; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Citrus; Flavanones; Hesperidin; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats | 2008 |
Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers.
Topics: Biological Transport; Caco-2 Cells; Chromatography, High Pressure Liquid; Epithelial Cells; Hesperidin; Humans; Models, Biological; Protons | 2008 |
Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry.
Topics: Anti-Bacterial Agents; Bacteriological Techniques; Citrus; Colony Count, Microbial; Flavanones; Flavonoids; Gram-Negative Bacteria; Gram-Positive Bacteria; Hesperidin; Microbial Sensitivity Tests; Oils, Volatile; Plant Extracts; Polygalacturonase; Saccharomyces cerevisiae | 2007 |
Pharmacokinetics of selected chiral flavonoids: hesperetin, naringenin and eriodictyol in rats and their content in fruit juices.
Topics: Animals; Area Under Curve; Beverages; Flavanones; Fruit; Half-Life; Hesperidin; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2008 |
Glycosylation of hesperetin by plant cell cultures.
Topics: Biotransformation; Cell Culture Techniques; Eucalyptus; Glycosylation; Hesperidin; Ipomoea batatas; Magnetic Resonance Spectroscopy; Molecular Structure; Reference Standards; Time Factors | 2008 |
Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells.
Topics: Cells, Cultured; Citrus; Endothelial Cells; Flavanones; Gene Expression; Hesperidin; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Phytoestrogens; RNA, Messenger; Umbilical Veins | 2008 |
Role of nitric oxide in regulating aldose reductase activation in the ischemic heart.
Topics: Aldehyde Reductase; Animals; Bradykinin; Dithiothreitol; Enzyme Activation; Enzyme Inhibitors; Ferric Compounds; Glucose; Hesperidin; Hypoglycemic Agents; Imidazolidines; Insulin; Lipid Peroxidation; Male; Metalloporphyrins; Myocardial Reperfusion Injury; Myocardium; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sorbitol; Vasodilator Agents | 2008 |
Effect of adding extracted hesperetin, naringenin and pectin on egg cholesterol, serum traits and antioxidant activity in laying hens.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Chickens; Cholesterol; Egg Yolk; Eggs; Female; Flavanones; Free Radical Scavengers; Hesperidin; Lipid Metabolism; Pectins; Random Allocation; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Triglycerides | 2008 |
Simultaneous determination of naringenin and hesperetin in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography-tandem mass spectrometry.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Drugs, Chinese Herbal; Flavanones; Hesperidin; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Tandem Mass Spectrometry | 2008 |
Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.
Topics: Acetylcholine; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Glucosides; Hesperidin; Hypertension; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Organ Culture Techniques; Rats; Rats, Inbred SHR; Rats, Wistar; Time; Vasodilation; Vasodilator Agents | 2008 |
Antioxidative effects of hesperetin against 7,12-dimethylbenz(a)anthracene-induced oxidative stress in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antioxidants; Biotransformation; Catalase; Electrophoresis, Polyacrylamide Gel; Glutathione; Glutathione Reductase; Hesperidin; Immunoblotting; Inactivation, Metabolic; Liver; Male; Mice; Mice, Inbred ICR; Oxidants; Oxidative Stress; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2008 |
Inhibition of oral carcinogenesis by citrus flavonoids.
Topics: Animals; Antineoplastic Agents; Cell Division; Chromatography, High Pressure Liquid; Citrus; Cricetinae; Flavanones; Flavones; Flavonoids; Hesperidin; Mouth Neoplasms; Random Allocation | 2008 |
Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation.
Topics: Animals; Antioxidants; Brain; Cell Death; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Hesperidin; Humans; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Oxidative Stress; Phosphorylation; Transcriptional Activation; Tumor Cells, Cultured | 2008 |
Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers.
Topics: ATP-Binding Cassette Transporters; Base Sequence; Caco-2 Cells; Chromatography, High Pressure Liquid; Citrus; DNA Primers; Hesperidin; Humans; Molecular Structure; Multidrug Resistance-Associated Protein 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrophotometry, Ultraviolet | 2008 |
The citrus flavonoids hesperetin and nobiletin differentially regulate low density lipoprotein receptor gene transcription in HepG2 liver cells.
Topics: Animals; Anticholesteremic Agents; Cell Line; Citrus; Dose-Response Relationship, Drug; Flavones; Flavonoids; Genes, Reporter; Hepatocytes; Hesperidin; Humans; Luciferases; Models, Animal; Promoter Regions, Genetic; Receptors, LDL; Regulatory Elements, Transcriptional; RNA, Messenger; Transcription, Genetic; Transfection | 2008 |
Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Catalase; Colonic Neoplasms; Colonic Polyps; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hesperidin; Lipid Peroxidation; Male; Microvilli; Rats; Rats, Wistar; Superoxide Dismutase; Survival Analysis; Thiobarbituric Acid Reactive Substances | 2009 |
Naringenin and hesperetin, two flavonoids derived from Citrus aurantium up-regulate transcription of adiponectin.
Topics: 3T3-L1 Cells; Adiponectin; Animals; Base Sequence; Citrus; DNA Primers; Dose-Response Relationship, Drug; Flavanones; Hesperidin; Mice; PPAR alpha; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Up-Regulation | 2008 |
Effect of hesperetin, a citrus flavonoid, on bacterial enzymes and carcinogen-induced aberrant crypt foci in colon cancer rats: a dose-dependent study.
Topics: 1,2-Dimethylhydrazine; Animals; Bacteria; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Citrus; Colon; Colonic Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Feces; Flavanones; Hesperidin; Injections, Subcutaneous; Intestinal Mucosa; Male; Phytotherapy; Precancerous Conditions; Rats; Rats, Wistar | 2008 |
Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.
Topics: Diosmin; Drug Stability; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Hesperidin; Humans; Linear Models; Male; Oxidation-Reduction; Reference Standards; Reproducibility of Results; Sensitivity and Specificity | 2009 |
Enantiomeric separation of some flavanones using shinorhizobial linear octasaccharides in CE.
Topics: Animals; Electrophoresis, Capillary; Flavanones; Flavones; Flavonoids; Hesperidin; Isomerism; Oligosaccharides; Polysaccharides, Bacterial; Sinorhizobium meliloti; Temperature | 2008 |
Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes.
Topics: Adipocytes; Adipogenesis; Apoptosis; Cell Differentiation; Cell Division; Cell Line; Flavanones; Hesperidin; Humans | 2008 |
Antagonistic interactions between the flavonoids hesperetin and naringenin and beta-lactam antibiotics against Staphylococcus aureus.
Topics: Cefoxitin; Drug Interactions; Flavanones; Flavonoids; Hesperidin; Methicillin; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Monobactams; Penicillins; Species Specificity | 2008 |
Influence of L-rhamnosyl-D-glucosyl derivatives on properties and biological interaction of flavonoids.
Topics: Animals; Apoptosis; Biomarkers; Biphenyl Compounds; Caspase 3; Cell Line, Tumor; Cell Proliferation; Flavonoids; Free Radicals; Hesperidin; Humans; Picrates; Polyamines; Rutin | 2009 |
Neuroprotective effects of chronic hesperetin administration in mice.
Topics: Animals; Antioxidants; Blotting, Western; Brain Chemistry; Catalase; Female; Glutathione; Hesperidin; Mice; Mice, Inbred ICR; Neuroprotective Agents; Oxidative Stress; Protein Carbonylation; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2008 |
Production and characterization of Hesperetin nanosuspensions for dermal delivery.
Topics: Administration, Cutaneous; Antioxidants; Drug Carriers; Drug Stability; Hesperidin; Molecular Structure; Nanoparticles; Particle Size; Scattering, Radiation; Solubility | 2009 |
Sulfation of dietary flavonoids by human sulfotransferases.
Topics: Arylsulfotransferase; Catechin; Cytosol; Flavanones; Hesperidin; Humans; Kinetics; Molecular Structure; Sulfotransferases | 2009 |
[Effects of Hesperetin on cell activation and proliferation of murine T lymphocytes in vitro].
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Cell Proliferation; Cell Survival; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Flow Cytometry; Hesperidin; Lectins, C-Type; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mitotic Index; T-Lymphocytes | 2009 |
Hesperetin stimulates differentiation of primary rat osteoblasts involving the BMP signalling pathway.
Topics: Alkaline Phosphatase; Animals; Bone Morphogenetic Proteins; Carrier Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Dose-Response Relationship, Drug; Gene Expression Regulation; Hesperidin; Minerals; Osteoblasts; Osteocalcin; Osteopontin; Phosphorylation; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Smad Proteins; Time Factors; Transcription Factors | 2010 |
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.
Topics: Animals; Cells, Cultured; Coculture Techniques; Flavanones; Hesperidin; Inflammation; Interferon-gamma; Lipopolysaccharides; Mice; Neuroglia; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; STAT1 Transcription Factor | 2009 |
Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Antineoplastic Agents, Phytogenic; Carcinogens; Citrus; Colon; Colonic Neoplasms; Hesperidin; Male; Rats | 2009 |
Statin-like principles of bergamot fruit (Citrus bergamia): isolation of 3-hydroxymethylglutaryl flavonoid glycosides.
Topics: Citrus; Flavanones; Flavonoids; Fruit; Glycosides; Hesperidin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular | 2009 |
Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone.
Topics: Animals; Antioxidants; Cattle; DNA; Hesperidin; Hydrazones; Lanthanoid Series Elements; Magnetics; Molecular Structure; Spectrometry, Fluorescence; Viscosity | 2009 |
Exploring the effect of Hesperetin-HSPC complex--a novel drug delivery system on the in vitro release, therapeutic efficacy and pharmacokinetics.
Topics: Animals; Antioxidants; Calibration; Carbon Tetrachloride Poisoning; Chemistry, Pharmaceutical; Drug Delivery Systems; Glycine max; Hesperidin; Liver Function Tests; Male; Phosphatidylcholines; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Solubility; Suspensions | 2009 |
Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Antineoplastic Agents, Phytogenic; Catalase; Colon; Colonic Neoplasms; Disease Models, Animal; Hesperidin; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Superoxide Dismutase | 2009 |
Dissolution rate and stability study of flavanone aglycones, naringenin and hesperetin, by drug delivery systems based on polyvinylpyrrolidone (PVP) nanodispersions.
Topics: Capsules; Chemistry, Pharmaceutical; Diffusion; Drug Compounding; Drug Delivery Systems; Drug Stability; Excipients; Flavanones; Hesperidin; Hot Temperature; Kinetics; Models, Chemical; Nanotechnology; Pharmaceutic Aids; Povidone; Solubility; Suspensions; Tablets; Time Factors; Water | 2010 |
Analysis of hesperetin enantiomers in human urine after ingestion of blood orange juice by using nano-liquid chromatography.
Topics: Chromatography, Liquid; Citrus; Coumarins; Hesperidin; Humans; Male; Stereoisomerism | 2010 |
Structural activity relationship of flavonoids with estrogen-related receptor gamma.
Topics: Apigenin; Flavanones; Flavonoids; Genistein; Heat-Shock Proteins; HeLa Cells; Hesperidin; Humans; Isoflavones; Luteolin; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Estrogen; Structure-Activity Relationship; Transcription Factors; Transcriptional Activation | 2010 |
Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation.
Topics: Animals; Cell Differentiation; Cells, Cultured; Gene Expression; Glucuronides; Hesperidin; Osteoblasts; Rats; Rats, Wistar | 2010 |
Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples.
Topics: Animals; Biotransformation; Cell Line; Chromatography, High Pressure Liquid; Colon; Cytosol; DNA, Complementary; Glucosides; Glucuronosyltransferase; Hesperidin; Humans; In Vitro Techniques; Insecta; Intestine, Small; Kinetics; Liver; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sulfates; Sulfotransferases; Transfection | 2010 |
In vitro permeation and in vivo whitening effect of topical hesperetin microemulsion delivery system.
Topics: 4-Aminobenzoic Acid; Administration, Cutaneous; Animals; Antioxidants; Drug Delivery Systems; Emulsions; Excipients; Guinea Pigs; Hesperidin; Hyperpigmentation; In Vitro Techniques; Male; Myristates; para-Aminobenzoates; Permeability; Rats; Rats, Sprague-Dawley; Skin Absorption; Surface-Active Agents; Ultraviolet Rays | 2010 |
The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Flavonoids; Glucuronides; Hesperidin; Humans; Neoplasm Proteins | 2010 |
Pharmacokinetics-based elucidation on disparity in clinical effectiveness between varieties of Zhi Zhu Wan, a Traditional Chinese Medical formula.
Topics: Administration, Oral; Adult; Animals; Area Under Curve; Asian People; Chromatography, High Pressure Liquid; Citrus; Citrus sinensis; Cricetinae; Cricetulus; Flavanones; Hesperidin; Humans; Male; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome Protein | 2010 |
Preserving hesperetin nanosuspensions for dermal application.
Topics: Administration, Topical; Drug Stability; Drug Storage; Electrochemistry; Hesperidin; Lasers; Light; Nanoparticles; Particle Size; Preservatives, Pharmaceutical; Scattering, Radiation; Skin Absorption; Suspensions; Temperature | 2010 |
The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Citrus; Fatty Acids, Nonesterified; Flavanones; Flavonoids; Hesperidin; Insulin Resistance; Lipolysis; Mice; Tumor Necrosis Factor-alpha | 2010 |
Extracellular monoenzyme deglycosylation system of 7-O-linked flavonoid beta-rutinosides and its disaccharide transglycosylation activity from Stilbella fimetaria.
Topics: Disaccharides; DNA, Fungal; DNA, Ribosomal; Enzyme Stability; Fungal Proteins; Genes, rRNA; Glucosidases; Hesperidin; Hypocreales; Isoelectric Point; Molecular Sequence Data; Molecular Weight; RNA, Fungal; RNA, Ribosomal, 18S; Sequence Analysis, DNA; Substrate Specificity; Temperature | 2010 |
Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans.
Topics: Adult; Beverages; Biological Availability; Chromatography, High Pressure Liquid; Citrus sinensis; Cross-Over Studies; Female; Flavanones; Fruit; Hesperidin; Humans; Intestinal Absorption; Male; Solubility | 2010 |
Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro.
Topics: Animals; Biological Transport; Caco-2 Cells; Cell Line, Tumor; Citrus sinensis; Cytosol; Fruit; Gene Expression; Glucuronides; Hesperidin; Humans; Intestine, Small; Liver Neoplasms, Experimental; Mice; Microsomes, Liver; Response Elements; Stereoisomerism; Structure-Activity Relationship; Sulfonic Acids; Transfection | 2010 |
Hesperidin and hesperetin membrane interaction: understanding the role of 7-O-glycoside moiety in flavonoids.
Topics: Biological Availability; Calorimetry, Differential Scanning; Citrus; Dimyristoylphosphatidylcholine; Glycosides; Hesperidin; Humans; Liposomes; Membrane Potentials; Membranes, Artificial; Microscopy, Atomic Force; Models, Molecular; Powder Diffraction; Spectrometry, Fluorescence; X-Ray Diffraction | 2010 |
The effect of component of cream for topical delivery of hesperetin.
Topics: Administration, Topical; Animals; Dosage Forms; Drug Delivery Systems; Guinea Pigs; Hesperidin; Male; Pigmentation; Rats; Rats, Sprague-Dawley; Skin; Solubility | 2010 |
Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.
Topics: Animals; Anthraquinones; Area Under Curve; Biphenyl Compounds; Chromatography, Liquid; Drugs, Chinese Herbal; Emodin; Female; Flavanones; Hesperidin; Lignans; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2010 |
Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cell Line; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fruit; Hesperidin; Humans; Inflammation Mediators; Interleukin-1; Interleukin-6; MAP Kinase Kinase 4; Matrix Metalloproteinase 3; Signal Transduction; Synovial Membrane | 2010 |
Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Caffeic Acids; Cholesterol; Cholesterol, HDL; Coumaric Acids; Cricetinae; Disease Models, Animal; Hesperidin; Humans; Hypercholesterolemia; Male; Mesocricetus | 2010 |
7,3'-dimethoxy hesperetin induces apoptosis of fibroblast-like synoviocytes in rats with adjuvant arthritis through caspase 3 activation.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Experimental; bcl-2-Associated X Protein; Caspase 3; Cells, Cultured; Fibroblasts; Hesperidin; Male; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Synovial Membrane | 2010 |
Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.
Topics: Animals; Brugia malayi; Coloring Agents; Disease Models, Animal; Elephantiasis, Filarial; Female; Filaricides; Flavanones; Flavonoids; Gerbillinae; Hesperidin; Humans; Male; Murinae; Rutin; Survival Analysis; Tetrazolium Salts; Thiazoles | 2010 |
Protective effects of silybin and analogues against X-ray radiation-induced damage.
Topics: Antioxidants; DNA; DNA Breaks, Single-Stranded; DNA Damage; Dose-Response Relationship, Radiation; Electrophoresis, Agar Gel; Flavanones; Hesperidin; Models, Chemical; Molecular Structure; Plasmids; Silybin; Silymarin | 2010 |
Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design.
Topics: Chromatography, Liquid; Flavonoids; Hesperidin; Honey; Micelles; Quercetin | 2010 |
Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.
Topics: Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Biocatalysis; Cytochrome P-450 CYP2C9; Diclofenac; Female; Flavonoids; Flurbiprofen; Hesperidin; Humans; Hydroxylation; Male; Microsomes, Liver; Models, Molecular; NADP; Pharmaceutical Preparations; Recombinant Proteins; Thermodynamics | 2010 |
Effects of gut microflora on pharmacokinetics of hesperidin: a study on non-antibiotic and pseudo-germ-free rats.
Topics: Animals; Anti-Bacterial Agents; beta-Glucosidase; Enterobacteriaceae; Feces; Germ-Free Life; Hesperidin; Intestines; Male; Rats; Rats, Sprague-Dawley | 2010 |
Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats.
Topics: Animals; Antioxidants; Cadmium; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Evaluation of binding and thermodynamic characteristics of interactions between a citrus flavonoid hesperitin with protein and effects of metal ions on binding.
Topics: Absorption; Animals; Binding Sites; Cattle; Circular Dichroism; Energy Transfer; Flavonoids; Fluorescence Polarization; Hesperidin; Ions; Kinetics; Metals; Protein Binding; Protein Structure, Secondary; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Thermodynamics | 2011 |
Anti-/pro-apoptotic effects of hesperetin against 7,12-dimetylbenz(a)anthracene-induced alteration in animals.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Dose-Response Relationship, Drug; Down-Regulation; Drug Administration Schedule; Drug Evaluation, Preclinical; Female; Hesperidin; Mammary Neoplasms, Animal; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Up-Regulation | 2011 |
Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFκB, p38 and caspase-3.
Topics: Animals; Caspase 3; Doxorubicin; Hesperidin; Immunohistochemistry; Lipid Peroxidation; Male; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Testis | 2011 |
Citrus flavonoids repress the mRNA for stearoyl-CoA desaturase, a key enzyme in lipid synthesis and obesity control, in rat primary hepatocytes.
Topics: Animals; Citrus; Enzyme Repression; Flavones; Gene Expression Regulation, Enzymologic; Hepatocytes; Hesperidin; Lipids; Liver; Male; Obesity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stearoyl-CoA Desaturase | 2011 |
Hesperetin, a potential therapy for carcinoid cancer.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Carcinoid Tumor; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gene Expression Regulation, Neoplastic; Hesperidin; Humans; Polymerase Chain Reaction; Receptor, Notch1; Signal Transduction; Stomach Neoplasms; Transcriptional Activation; Up-Regulation | 2011 |
Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells.
Topics: Animals; Hesperidin; Hydrogen Peroxide; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Estrogen; Signal Transduction | 2011 |
Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Apoptosis; Caspase 3; Comet Assay; Cytoprotection; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Glutathione; Heart Diseases; Hesperidin; In Situ Nick-End Labeling; Male; Malondialdehyde; Myocytes, Cardiac; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
Conjugates of 3α-methoxyserrat-14-en-21β-ol (PJ-1) and 3β-methoxyserrat-14-en-21β-ol (PJ-2) as cancer chemopreventive agents.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antigens, Viral; Carcinogenicity Tests; Cell Transformation, Neoplastic; Epstein-Barr Virus Infections; Flavanones; Genistein; Herpesvirus 4, Human; Hesperidin; Isoflavones; Mice; Oleanolic Acid; Skin Neoplasms; Tetradecanoylphorbol Acetate; Triterpenes | 2011 |
Hesperidin induces antinociceptive effect in mice and its aglycone, hesperetin, binds to μ-opioid receptor and inhibits GIRK1/2 currents.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Hesperidin; Humans; Male; Mice; Pain Measurement; Potassium Channel Blockers; Protein Binding; Rats; Receptors, Opioid, mu; Xenopus laevis | 2011 |
Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats.
Topics: Animals; Antioxidants; Cadmium; Cadmium Chloride; Citrus; Hesperidin; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Testicular Diseases; Testis | 2011 |
Interaction of a functionalized complex of the flavonoid hesperetin with the AhR pathway and CYP1A1 expression: involvement in its protective effects against benzo[a]pyrene-induced oxidative stress in human skin.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Benzo(a)pyrene; beta-Cyclodextrins; Cell Death; Cytochrome P-450 CYP1A1; Flavonoids; Hesperidin; Humans; In Vitro Techniques; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Signal Transduction; Skin | 2011 |
Dietary flavones and flavonones display differential effects on aromatase (CYP19) transcription in the breast cancer cells MCF-7.
Topics: Apigenin; Aromatase; Aromatase Inhibitors; Breast Neoplasms; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Enzyme Assays; Female; Flavanones; Genes, Reporter; Hesperidin; Humans; Luciferases, Firefly; Luteolin; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Transcription Factor AP-1; Transcription, Genetic | 2011 |
Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin.
Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2C8; Flavonoids; Hesperidin; Humans; Inactivation, Metabolic; Microsomes, Liver; Molecular Dynamics Simulation; Paclitaxel | 2011 |
Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey.
Topics: Antioxidants; Biphenyl Compounds; Caffeic Acids; Chlorogenic Acid; Chromatography, High Pressure Liquid; Coumaric Acids; Ellagic Acid; Food Irradiation; Gamma Rays; Gastrointestinal Diseases; Hesperidin; Honey; Humans; Malaysia; Oxidation-Reduction; Picrates; Propionates; Quercetin; Spectrophotometry | 2011 |
Tissue distribution of hesperetin in rats after a dietary intake.
Topics: Animals; Aorta; Biological Availability; Capillary Permeability; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrus; Diet; Hesperidin; Liver; Male; Rats; Rats, Wistar; Tissue Distribution | 2011 |
Microbial metabolism. Part 13. Metabolites of hesperetin.
Topics: Antineoplastic Agents; Antioxidants; Drug Screening Assays, Antitumor; Fermentation; Flavanones; Hesperidin; Molecular Structure; Mucor | 2011 |
UPLC-MS/MS quantification of total hesperetin and hesperetin enantiomers in biological matrices.
Topics: Chromatography, Liquid; Hesperidin; Humans; Reference Standards; Stereoisomerism; Tandem Mass Spectrometry | 2012 |
Analysis of flavonoids by capillary zone electrophoresis with electrokinetic supercharging.
Topics: Clematis; Electrophoresis, Capillary; Flavanones; Flavonoids; Hesperidin; Sensitivity and Specificity; Taurine | 2011 |
Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study.
Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Benzothiazoles; Biomarkers; Biphenyl Compounds; Cadmium Chloride; Dose-Response Relationship, Drug; Environmental Pollutants; Glutathione; Hesperidin; Hydroxyl Radical; Injections, Subcutaneous; Lipid Peroxidation; Lipid Peroxides; Male; Oxidative Stress; Picrates; Rats; Rats, Wistar; Sulfonic Acids; Thiobarbituric Acid Reactive Substances; Vitamin E | 2011 |
Simultaneous determination of naringin, hesperidin, neohesperidin, naringenin and hesperetin of Fractus aurantii extract in rat plasma by liquid chromatography tandem mass spectrometry.
Topics: Animals; Chromatography, Liquid; Flavanones; Fruit; Glucosides; Hesperidin; Male; Rats; Rats, Wistar; Reference Standards; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Baculoviridae; Cell Line; Cell Membrane; Glucuronides; Hesperidin; Humans; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Spodoptera; Transport Vesicles | 2011 |
Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study.
Topics: Algorithms; Anilino Naphthalenesulfonates; Binding Sites; Catalytic Domain; Computer Simulation; Flavones; Flavonoids; Hesperidin; Kinetics; Levodopa; Models, Chemical; Models, Molecular; Monophenol Monooxygenase; Spectrometry, Fluorescence; Spectrophotometry | 2012 |
Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Citrus; Hesperidin; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Rats; Rats, Sprague-Dawley; Serum | 2012 |
Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study.
Topics: Adenocarcinoma; Apoptosis; Catalase; Colonic Neoplasms; DNA Damage; Glutathione Peroxidase; Hesperidin; HT29 Cells; Humans; Lipid Peroxidation; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2012 |
Antiviral activity of four types of bioflavonoid against dengue virus type-2.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Dengue; Dengue Virus; Flavanones; Flavonoids; Flavonols; Hesperidin; Inhibitory Concentration 50; Phytotherapy; Quercetin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Vero Cells; Virus Replication | 2011 |
The citrus flavonone hesperetin inhibits growth of aromatase-expressing MCF-7 tumor in ovariectomized athymic mice.
Topics: Animals; Aromatase; Aromatase Inhibitors; bcl-X Protein; Breast Neoplasms; Cell Proliferation; Citrus; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p57; Estradiol; Estrogens; Female; Hesperidin; Humans; MCF-7 Cells; Mice; Mice, Nude; Ovariectomy; RNA, Messenger; Xenograft Model Antitumor Assays | 2012 |
Intravitreal kinetics of hesperidin, hesperetin, and hesperidin G: effect of dose and physicochemical properties.
Topics: Animals; Dose-Response Relationship, Drug; Glucosides; Hesperidin; Male; Rabbits; Vitreous Body | 2012 |
Production of hesperetin glycosides by Xanthomonas campestris and cyclodextrin glucanotransferase and their anti-allergic activities.
Topics: Animals; Glucosyltransferases; Glycosides; Glycosylation; Hesperidin; Immunoglobulin E; Neutrophils; Rats; Xanthomonas campestris | 2010 |
Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid.
Topics: Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Citrus; Flavonoids; Hesperidin; Hydrolysis; Melanins; Melanoma, Experimental; Mice; Plant Extracts | 2012 |
An investigation on the interaction of DNA with hesperetin/apigenin in the presence of CTAB by resonance Rayleigh light scattering technique and its analytical application.
Topics: Apigenin; Cetrimonium; Cetrimonium Compounds; Detergents; DNA; Hesperidin; Hydrogen-Ion Concentration; Light; Limit of Detection; Spectrometry, Fluorescence; Vibration | 2012 |
Interaction of antioxidant flavonoids with calf thymus DNA analyzed by spectroscopic and electrochemical methods.
Topics: Antioxidants; Circular Dichroism; DNA; Electrochemical Techniques; Ethidium; Flavanones; Fluorescence Polarization; Hesperidin; Intercalating Agents; Molecular Structure; Nucleic Acid Conformation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Spectrum Analysis; Thermodynamics; Transition Temperature | 2012 |
Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Biological Transport; Cell Line; Cytoprotection; Down-Regulation; Energy Metabolism; Glucose; Glucose Transporter Type 3; Glucose Transporter Type 4; Hesperidin; Mice; Neurons; Neuroprotective Agents; Peptide Fragments; Proto-Oncogene Proteins c-akt; RNA, Messenger | 2012 |
Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; Hesperidin; Male; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Vascular Endothelial Growth Factor A | 2012 |
Protective effects of fermented Citrus unshiu peel extract against ultraviolet-A-induced photoageing in human dermal fibrobolasts.
Topics: beta-Galactosidase; Cells, Cultured; Citrus; Collagen; Dermis; Disaccharides; Fermentation; Fibroblasts; Flavanones; Fruit; Hesperidin; Humans; Matrix Metalloproteinase 1; Plant Extracts; Schizophyllum; Skin Aging; Ultraviolet Rays | 2012 |
Hesperetin upregulates ABCA1 expression and promotes cholesterol efflux from THP-1 macrophages.
Topics: ATP-Binding Cassette Transporters; Hesperidin; Humans; Lipoproteins, HDL; Liver X Receptors; Macrophages; Molecular Structure; Orphan Nuclear Receptors; PPAR gamma; RNA, Messenger | 2012 |
Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.
Topics: Flavonoids; Gene Expression; Heat-Shock Proteins; Hesperidin; Membrane Proteins; Mitochondrial Proteins; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirtuin 2; Superoxide Dismutase; Time Factors | 2012 |
Phytonutrient intake by adults in the United States in relation to fruit and vegetable consumption.
Topics: Adult; Antioxidants; Carotenoids; Cryptoxanthins; Diet; Ellagic Acid; Energy Intake; Feeding Behavior; Female; Fruit; Guidelines as Topic; Hesperidin; Humans; Interviews as Topic; Lycopene; Male; Micronutrients; Middle Aged; Nutrition Surveys; United States; Vegetables; Xanthophylls; Young Adult | 2012 |
Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells.
Topics: Animals; Antioxidants; Cell Survival; Citrus; Cyclic AMP Response Element-Binding Protein; Hesperidin; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Neuroprotective Agents; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; PC12 Cells; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; Rats; Receptors, Estrogen; RNA-Binding Proteins; Signal Transduction; Transcription Factors | 2012 |
Evaluation of the intravenous and topical routes for ocular delivery of hesperidin and hesperetin.
Topics: Administration, Ophthalmic; Animals; Benzalkonium Compounds; Biological Availability; Drug Delivery Systems; Excipients; Feasibility Studies; Glucuronides; Hesperidin; Hydrophobic and Hydrophilic Interactions; Injections, Intravenous; Male; Rabbits; Time Factors; Vitreous Body | 2012 |
Antiproliferative efficacy of hesperetin (citrus flavanoid) in 1,2-dimethylhydrazine-induced colon cancer.
Topics: 1,2-Dimethylhydrazine; Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Carcinogens; Cell Transformation, Neoplastic; Colonic Neoplasms; Hesperidin; Male; Nucleolus Organizer Region; Phytotherapy; Plant Extracts; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar | 2013 |
Anti-degranulating activity in rat basophil leukemia RBL-2H3 cells of flavanone glycosides and their aglycones in citrus fruits.
Topics: Animals; Anti-Allergic Agents; Basophil Degranulation Test; Basophils; Calcium; Calcium Ionophores; Cell Degranulation; Cell Line, Tumor; Citrus; Disaccharides; Dose-Response Relationship, Drug; Flavanones; Glycosides; Hesperidin; Intracellular Signaling Peptides and Proteins; Leukemia; Phosphorylation; Plant Extracts; Plants, Medicinal; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; src-Family Kinases; Syk Kinase | 2013 |
The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; fas Receptor; Female; Flow Cytometry; Hesperidin; Humans; In Situ Nick-End Labeling; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Mitochondria; Real-Time Polymerase Chain Reaction; Time Factors; Uterine Cervical Neoplasms | 2013 |
Protective effects of hesperidin derivatives and their stereoisomers against advanced glycation end-products formation.
Topics: Glucose; Glucosides; Glycation End Products, Advanced; Hesperidin; High-Throughput Screening Assays; Hypoglycemic Agents; Maillard Reaction; Molecular Structure; Pyruvaldehyde; Ribonuclease, Pancreatic; Serum Albumin, Bovine; Stereoisomerism; Structure-Activity Relationship | 2012 |
7,3'-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis.
Topics: Animals; Apoptosis; Arthritis, Experimental; bcl-2-Associated X Protein; Hesperidin; Inflammation; Interleukin-1beta; Male; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Synovial Membrane; Tumor Necrosis Factor-alpha | 2013 |
Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells.
Topics: Antigens, CD; Antineoplastic Agents, Phytogenic; Biological Transport; Cell Line, Tumor; Cell Proliferation; Female; Flavones; Gene Expression Regulation, Neoplastic; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Hesperidin; Humans; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction | 2013 |
Hesperidinase encapsulation towards hesperitin production targeting improved bioavailability.
Topics: Adsorption; Alginates; Aspergillus niger; Biological Availability; Buffers; Carrageenan; Chitosan; Cross-Linking Reagents; Drug Compounding; Enzymes, Immobilized; Fungal Proteins; Glucuronic Acid; Glutaral; Glycoside Hydrolases; Half-Life; Hesperidin; Hexuronic Acids; Hydrogels; Kinetics | 2012 |
Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves.
Topics: Camellia sinensis; Catechin; Citrus sinensis; Dietary Supplements; Flavonoids; Fruit; Hesperidin; Humans; Inhibitory Concentration 50; Plant Leaves; Rutin; Trypsin; Trypsin Inhibitors | 2013 |
Pharmacokinetics of hesperetin and naringenin in the Zhi Zhu Wan, a traditional Chinese medicinal formulae, and its pharmacodynamics study.
Topics: Administration, Oral; Animals; Atractylodes; Chromatography, Liquid; Citrus; Drugs, Chinese Herbal; Flavanones; Gastrointestinal Motility; Hesperidin; Intestines; Male; Mice; Mice, Inbred ICR; Plasma; Tandem Mass Spectrometry | 2013 |
Hesperetin: an inhibitor of the transforming growth factor-β (TGF-β) signaling pathway.
Topics: Antineoplastic Agents; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Hesperidin; Humans; Signal Transduction; Structure-Activity Relationship; Transforming Growth Factor beta; Tumor Cells, Cultured | 2012 |
Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.
Topics: Animals; Benzoin; Calcium; Calcium Channel Blockers; Calcium Signaling; Citrus; Drug Evaluation, Preclinical; Fabaceae; Flavanones; Ganglia, Spinal; HEK293 Cells; Hesperidin; Humans; Membrane Potentials; Mice; Mice, Inbred C57BL; Pregnenolone; Rats; Rats, Wistar; Secondary Metabolism; TRPM Cation Channels | 2013 |
Assessment of phytochemical content in human milk during different stages of lactation.
Topics: Adult; Carotenoids; Catechin; Cryptoxanthins; Female; Flavanones; Flavonoids; Hesperidin; Humans; Kaempferols; Lactation; Lutein; Lycopene; Milk, Human; Postpartum Period; Pregnancy; Quercetin; Time Factors; Xanthophylls; Zeaxanthins | 2013 |
The citrus flavonone hesperetin prevents letrozole-induced bone loss in a mouse model of breast cancer.
Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Cell Line, Tumor; Citrus; Estradiol; Female; Hesperidin; Humans; Letrozole; MCF-7 Cells; Mice; Mice, Nude; Nitriles; Osteoporosis; Selective Estrogen Receptor Modulators; Triazoles; Xenograft Model Antitumor Assays | 2013 |
A comparison study on the binding of hesperetin and luteolin to bovine serum albumin by spectroscopy.
Topics: Animals; Binding Sites; Cattle; Drugs, Chinese Herbal; Hesperidin; Luteolin; Protein Binding; Protein Conformation; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Thermodynamics | 2013 |
Flavanone metabolites decrease monocyte adhesion to TNF-α-activated endothelial cells by modulating expression of atherosclerosis-related genes.
Topics: Atherosclerosis; Cell Adhesion; Endothelial Cells; Flavanones; Gene Expression Profiling; Gene Expression Regulation; Glucuronides; Hesperidin; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Monocytes; Sulfates; Tumor Necrosis Factor-alpha | 2013 |
Prunin- and hesperetin glucoside-alkyl (C4-C18) esters interaction with Jurkat cells plasma membrane: consequences on membrane physical properties and antioxidant capacity.
Topics: Antioxidants; Cell Membrane; Esters; Hesperidin; Humans; Jurkat Cells; Phlorhizin | 2013 |
Hesperetin rescues retinal oxidative stress, neuroinflammation and apoptosis in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Aquaporin 4; Blood Glucose; Body Weight; Caspase 3; Catalase; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Glial Fibrillary Acidic Protein; Glutathione; Hesperidin; Immunohistochemistry; Inflammation; Inflammation Mediators; Interleukin-1beta; Male; Microscopy, Electron, Transmission; Oxidative Stress; Rats; Rats, Wistar; Retina; Streptozocin; Superoxide Dismutase; Time Factors; Tumor Necrosis Factor-alpha | 2013 |
5,7,3'-Triacetyl hesperetin suppresses adjuvant-induced arthritis in rats through modulating JAK2/STAT3 pathway.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Citrus; Edema; Freund's Adjuvant; Hesperidin; Interleukin-6; Janus Kinase 2; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Synovial Membrane | 2013 |
Hesperetin protects against cardiac remodelling induced by pressure overload in mice.
Topics: Animals; Body Weight; Cardiomegaly; Cardiotonic Agents; Fibrosis; Gene Expression Regulation; Heart; Hesperidin; Male; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Organ Size; Oxidative Stress; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins c-akt; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Ventricular Pressure; Ventricular Remodeling | 2013 |
Hesperetin alleviates the inhibitory effects of high glucose on the osteoblastic differentiation of periodontal ligament stem cells.
Topics: Alkaline Phosphatase; beta Catenin; Cell Differentiation; Cells, Cultured; Gene Expression; Glucose; Hesperidin; Humans; Osteoblasts; Osteogenesis; Periodontal Ligament; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Stem Cells; Transcription Factors | 2013 |
Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using felodipine and hesperetin in combination in Wistar rats and everted rat gut sacs in vitro.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cytochrome P-450 CYP3A; Felodipine; Half-Life; Hesperidin; Ileum; In Vitro Techniques; Intestinal Absorption; Male; Rats; Rats, Wistar; Verapamil | 2014 |
Antianxiety-like effects of Chimpi (dried citrus peels) in the elevated open-platform test.
Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Citrus; Hesperidin; Male; Mice; Mice, Inbred ICR; Motor Activity | 2013 |
Molecular mechanism underlying hesperetin-induced apoptosis by in silico analysis and in prostate cancer PC-3 cells.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; bcl-X Protein; Blotting, Western; Cell Proliferation; Hesperidin; Humans; Male; NF-kappa B; Prostatic Neoplasms; Protein Conformation; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2013 |
Simplified miniaturized ultrasound-assisted matrix solid phase dispersion extraction and high performance liquid chromatographic determination of seven flavonoids in citrus fruit juice and human fluid samples: hesperetin and naringenin as biomarkers.
Topics: Beverages; Biomarkers; Chromatography, High Pressure Liquid; Citrus; Female; Flavanones; Fruit; Hesperidin; Humans; Limit of Detection; Male; Miniaturization; Solid Phase Extraction; Sound | 2013 |
Production of hesperetin using a covalently multipoint immobilized diglycosidase from Acremonium sp. DSM24697.
Topics: Acremonium; Enzymes, Immobilized; Glycoside Hydrolases; Hesperidin; Microspheres; Sepharose; Temperature; Time Factors | 2013 |
Antimicrobial effect of 7-O-butylnaringenin, a novel flavonoid, and various natural flavonoids against Helicobacter pylori strains.
Topics: Anti-Bacterial Agents; Flavanones; Flavonoids; Helicobacter pylori; Hesperidin; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Urease | 2013 |
Molecular relaxation behavior and isothermal crystallization above glass transition temperature of amorphous hesperetin.
Topics: Crystallization; Glass; Hesperidin; Kinetics; Temperature; Transition Temperature | 2014 |
Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts.
Topics: beta-Glucosidase; Citrus; Detergents; Disaccharides; Flavanones; Flavonoids; Food Industry; Glycosides; Hesperidin; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Plant Extracts; Pyrococcus furiosus; Solvents; Substrate Specificity; Temperature | 2013 |
Molecular mechanisms of citrus flavanones on hepatic gluconeogenesis.
Topics: Animals; Biological Transport; Citrus; Diabetes Mellitus, Type 2; Flavanones; Gluconeogenesis; Glucose; Hesperidin; Hyperglycemia; Hypoglycemic Agents; Liver; Mitochondria; Phytotherapy; Plant Extracts; Pyruvic Acid; Rats; Rats, Wistar; Structure-Activity Relationship | 2014 |
Citrus flavanones affect hepatic fatty acid oxidation in rats by acting as prooxidant agents.
Topics: Animals; Antioxidants; Citrus; Flavanones; Hepatocytes; Hesperidin; Humans; Lipid Metabolism; Liver; Male; Mitochondria, Liver; Oxidation-Reduction; Peroxisomes; Rats; Reactive Oxygen Species | 2013 |
Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Dietary Supplements; Endothelium, Vascular; Enzyme Repression; Glucosides; Hesperidin; Hypertension; In Vitro Techniques; Male; NADPH Oxidases; Protein Subunits; Random Allocation; Rats; Rats, Inbred SHR; Solubility; Thromboxane B2; Thromboxane-A Synthase; Vascular Resistance | 2013 |
Hesperetin activates the Notch1 signaling cascade, causes apoptosis, and induces cellular differentiation in anaplastic thyroid cancer.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Cycle Proteins; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Gene Expression; Hesperidin; Homeodomain Proteins; Humans; Nuclear Proteins; Paired Box Transcription Factors; PAX8 Transcription Factor; Receptor, Notch1; Receptors, Thyrotropin; Signal Transduction; Symporters; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Thyroid Nuclear Factor 1; Transcription Factor HES-1; Transcription Factors | 2014 |
Hesperetin attenuates mitochondria-dependent apoptosis in lipopolysaccharide-induced H9C2 cardiomyocytes.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line; Cell Survival; Hesperidin; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Mitochondria; Myocytes, Cardiac; Rats; Signal Transduction | 2014 |
Protective effect of hesperetin and naringenin against apoptosis in ischemia/reperfusion-induced retinal injury in rats.
Topics: Animals; Apoptosis; Flavanones; Hesperidin; Male; Rats; Rats, Wistar; Reperfusion Injury; Retina | 2014 |
UPLC-MS-ELSD-PDA as a powerful dereplication tool to facilitate compound identification from small-molecule natural product libraries.
Topics: Arizona; Biological Products; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Databases, Factual; Diterpenes; Flavones; Hesperidin; Mass Spectrometry; Molecular Conformation; Molecular Structure; Plant Leaves; Small Molecule Libraries; Thuja | 2014 |
Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cell Differentiation; Cells, Cultured; Cytokines; Escherichia coli; Hesperidin; Humans; I-kappa B Proteins; Inflammation; Leukocytes; Leukocytes, Mononuclear; Lipopolysaccharides; Monocytes; Neutrophils; NF-KappaB Inhibitor alpha; Phloretin; Resveratrol; RNA, Messenger; Silymarin; Stilbenes | 2014 |
Nanosuspensions of hesperetin: preparation and characterization.
Topics: Chemistry, Pharmaceutical; Drug Stability; Electrochemistry; Hesperidin; Light; Nanoparticles; Nanostructures; Particle Size; Preservatives, Pharmaceutical; Scattering, Radiation; Surface-Active Agents; Suspensions | 2014 |
Rhizobium tibeticum activated with a mixture of flavonoids alleviates nickel toxicity in symbiosis with fenugreek (Trigonella foenum graecum L.).
Topics: Apigenin; Flavonoids; Glutamate-Ammonia Ligase; Hesperidin; Nickel; Nitrogen Fixation; Nod Signaling Adaptor Proteins; Phenylalanine Ammonia-Lyase; Plant Exudates; Plant Root Nodulation; Random Allocation; Rhizobium; Stress, Physiological; Symbiosis; Trigonella | 2014 |
Hesperetin inhibits rat coronary constriction by inhibiting Ca(2+) influx and enhancing voltage-gated K(+) channel currents of the myocytes.
Topics: Animals; Calcium; Coronary Vessels; Hesperidin; In Vitro Techniques; Male; Myocardial Contraction; Myocytes, Smooth Muscle; Potassium Channels, Voltage-Gated; Rats, Wistar; Vasoconstriction | 2014 |
Mechanism of peroxisome proliferator-activated receptor gamma (PPARγ) transactivation by hesperetin glucuronides is distinct from that by a thiazolidine-2,4-dione agent.
Topics: Animals; Binding Sites; Cells, Cultured; Chlorocebus aethiops; COS Cells; Hesperidin; Humans; Models, Molecular; Molecular Structure; PPAR gamma; Structure-Activity Relationship; Thiazolidinediones | 2014 |
The effect of hesperetin on ischemia-reperfusion injury in rat ovary.
Topics: Animals; Apoptosis; Caspase 3; Dimethyl Sulfoxide; Edema; Female; Hemorrhage; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Ovary; Rats, Wistar; Reperfusion; Reperfusion Injury; Solvents; Torsion, Mechanical | 2014 |
Protective effect of hesperetin in rat model of partial sciatic nerve ligation induced painful neuropathic pain: an evidence of anti-inflammatory and anti-oxidative activity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Female; Hesperidin; Male; Neuralgia; Rats; Rats, Wistar; RNA, Messenger; Sciatic Nerve; Tumor Necrosis Factor-alpha | 2014 |
A flavonoid fraction purified from Rutaceae aurantiae (Daflon(R)) inhibiting AGE formation, reduces urinary albumin clearance and corrects hypoalbuminemia in normotensive and hypertensive diabetic rats.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diosmin; Flavonoids; Fructosamine; Glomerular Basement Membrane; Glycation End Products, Advanced; Hesperidin; Hyperglycemia; Hypoalbuminemia; Kidney Glomerulus; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Rats, Inbred SHR; Rats, Wistar; Rutaceae | 2014 |
Hesperetin glucuronides induce adipocyte differentiation via activation and expression of peroxisome proliferator-activated receptor-γ.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Chlorocebus aethiops; Chromans; COS Cells; Drug Synergism; Gene Expression Regulation; Glucuronides; Hesperidin; Mice; PPAR gamma; Protein Structure, Tertiary; Thiazolidinediones; Troglitazone | 2014 |
Encapsulation and micronization effectively improve orange beverage flavanone bioavailability in humans.
Topics: Adult; Beverages; Biological Availability; Citrus sinensis; Drug Compounding; Hesperidin; Humans; Male; Middle Aged; Particle Size | 2014 |
Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Enzyme Activation; Flow Cytometry; Hesperidin; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; MCF-7 Cells; Membrane Potential, Mitochondrial; Reactive Oxygen Species; RNA, Small Interfering; Transfection | 2015 |
[Effect of different compatibility of zhizi dahuang decoction on pharmacokinetics of naringenin and hesperetin].
Topics: Animals; Chromatography, High Pressure Liquid; Citrus; Drug Incompatibility; Drug Interactions; Drugs, Chinese Herbal; Flavanones; Gardenia; Hesperidin; Rats; Rats, Sprague-Dawley | 2014 |
Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis.
Topics: Adipogenesis; Apoptosis; bcl-2-Associated X Protein; Hesperidin; Humans; Lipolysis; Mesenchymal Stem Cells; Proto-Oncogene Proteins p21(ras) | 2015 |
Establishment of a melanogenesis regulation assay system using a fluorescent protein reporter combined with the promoters for the melanogenesis-related genes in human melanoma cells.
Topics: Acetophenones; Arbutin; Benzopyrans; Cell Line, Tumor; Drug Evaluation, Preclinical; Enzyme Induction; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genes, Synthetic; Green Fluorescent Proteins; Hesperidin; Humans; Intramolecular Oxidoreductases; Melanins; Melanoma; Melanoma, Experimental; Microphthalmia-Associated Transcription Factor; Microscopy, Fluorescence; Monophenol Monooxygenase; Neoplasm Proteins; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; Skin Lightening Preparations; Theophylline; Transfection | 2015 |
Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: in vitro and in vivo investigations.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Survival; Deoxycholic Acid; Drug Carriers; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Stability; Female; Flavanones; Hesperidin; Humans; Hyaluronic Acid; Male; MCF-7 Cells; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitoxantrone; Nanoparticles; Neoplasm Proteins; Particle Size; Quercetin; Rats, Wistar; Surface Properties; Tissue Distribution | 2014 |
Chelating ability and biological activity of hesperetin Schiff base.
Topics: Chelating Agents; Copper; DNA; Flavanones; Hesperidin; Plasmids; Schiff Bases | 2015 |
[Hesperetin attenuates angiotensin II-induced collagen expression in cardiac fibroblasts in vitro].
Topics: Angiotensin II; Cell Proliferation; Collagen; Fibroblasts; Gene Expression; Heart; Hesperidin; In Vitro Techniques; Matrix Metalloproteinase 1; Reactive Oxygen Species | 2014 |
In vitro colonic catabolism of orange juice (poly)phenols.
Topics: Adult; Beverages; Chromatography, High Pressure Liquid; Citrus sinensis; Colon; Coumaric Acids; Feces; Female; Fermentation; Flavanones; Gas Chromatography-Mass Spectrometry; Hesperidin; Humans; In Vitro Techniques; Male; Polyphenols | 2015 |
Effects of the flavanone combination hesperetin-naringenin, and orange and grapefruit juices, on airway inflammation and remodeling in a murine asthma model.
Topics: Airway Remodeling; Animals; Asthma; Beverages; Bronchoalveolar Lavage Fluid; Citrus paradisi; Citrus sinensis; Disease Models, Animal; Eosinophils; Flavanones; Fruit; Hesperidin; Inflammation; Lung; Macrophages; Male; Mice; Mice, Inbred BALB C | 2015 |
Biological activity of natural flavonoids as impacted by protein flexibility: an example of flavanones.
Topics: Binding Sites; Flavanones; Hesperidin; Humans; Molecular Docking Simulation; Pliability; Protein Binding; Protein Conformation; Serum Albumin | 2015 |
Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Free Radical Scavengers; HeLa Cells; Hesperidin; Humans; Hydroquinones; Origanum; Oxidation-Reduction; Phenols; Plant Components, Aerial; Plant Extracts; Rats | 2016 |
Evaluation of topical hesperetin matrix film for back-of-the-eye delivery.
Topics: Administration, Topical; Animals; Cornea; Drug Compounding; Drug Delivery Systems; Drug Liberation; Eye; Hesperidin; Male; Polyethylene Glycols; Rabbits; Time Factors; Tissue Distribution | 2015 |
Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Blotting, Western; Calcium; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Cell Proliferation; Cytoplasm; Hesperidin; Humans; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Reactive Oxygen Species; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2015 |
Hesperetin induces melanin production in adult human epidermal melanocytes.
Topics: Animals; Cell Line; Epidermal Cells; Hesperidin; Humans; Melanins; Melanocytes; Melanoma; Mice; Molecular Structure | 2015 |
Oral bioavailability and pharmacodynamic activity of hesperetin nanocrystals generated using a novel bottom-up technology.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Biological Availability; Caco-2 Cells; Calorimetry, Differential Scanning; Carrageenan; Chemistry, Pharmaceutical; Crystallization; Crystallography, X-Ray; Female; Hesperidin; Humans; Mannitol; MCF-7 Cells; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Technology, Pharmaceutical; Thermogravimetry; Tumor Necrosis Factor-alpha; X-Ray Diffraction | 2015 |
Urinary Excretion of Select Dietary Polyphenol Metabolites Is Associated with a Lower Risk of Type 2 Diabetes in Proximate but Not Remote Follow-Up in a Prospective Investigation in 2 Cohorts of US Women.
Topics: Adult; Aged; Aged, 80 and over; Caffeic Acids; Case-Control Studies; Catechin; Coumaric Acids; Diabetes Mellitus, Type 2; Female; Flavanones; Follow-Up Studies; Hesperidin; Humans; Hydroxybenzoates; Middle Aged; Nutrition Assessment; Polyphenols; Prospective Studies; Quercetin; Risk Factors; Surveys and Questionnaires | 2015 |
Preparation, characterization and application of molecularly imprinted monolithic column for hesperetin.
Topics: Acrylamide; Adsorption; Chromatography, High Pressure Liquid; Citrus; Hesperidin; Medicine, Chinese Traditional; Methanol; Molecular Imprinting; Plant Extracts; Polymerization; Polymers; Rutin; Solid Phase Extraction | 2015 |
Evaluation of Antitumor Activity of Hesperetin-Loaded Nanoparticles Against DMBA-Induced Oral Carcinogenesis Based on Tissue Autofluorescence Spectroscopy and Multivariate Analysis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Hesperidin; Male; Mesocricetus; Mouth Neoplasms; Multivariate Analysis; Nanoparticles; ROC Curve; Spectrometry, Fluorescence | 2015 |
Hesperetin Induces the Apoptosis of Gastric Cancer Cells via Activating Mitochondrial Pathway by Increasing Reactive Oxygen Species.
Topics: Analysis of Variance; Animals; Apoptosis; Blotting, Western; Cell Proliferation; Female; Hesperidin; Heterografts; Humans; In Situ Nick-End Labeling; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Reactive Oxygen Species; Reference Values; Stomach Neoplasms; Tumor Cells, Cultured | 2015 |
Validation of RP-HPLC Method for Simultaneous Quantification of Bicalutamide and Hesperetin in Polycaprolactone-Bicalutamide-Hesperetin-Chitosan Nanoparticles.
Topics: Anilides; Antineoplastic Agents; Chitosan; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Hesperidin; Limit of Detection; Linear Models; Nanoparticles; Nitriles; Polyesters; Reproducibility of Results; Tosyl Compounds | 2015 |
The pleiotropic effects of fisetin and hesperetin on human acute promyelocytic leukemia cells are mediated through apoptosis, cell cycle arrest, and alterations in signaling networks.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Flavonoids; Flavonols; Gene Expression Regulation, Neoplastic; Hesperidin; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Membrane Potential, Mitochondrial; Neoplasm Proteins; Signal Transduction | 2015 |
Effect of Mannitol on Nucleation and Crystal Growth of Amorphous Flavonoids: Implications on the Formation of Nanocrystalline Solid Dispersion.
Topics: Calorimetry, Differential Scanning; Crystallization; Excipients; Flavanones; Hesperidin; Kinetics; Mannitol; Phase Transition; Powder Diffraction; Thermodynamics; X-Ray Diffraction | 2015 |
Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2.
Topics: Anti-Inflammatory Agents; Caco-2 Cells; Flavanones; Hesperidin; Humans; Intestinal Absorption; Monocarboxylic Acid Transporters; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins | 2015 |
Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Controls Efflux Transport of Hesperetin Sulfates in Sulfotransferase 1A3-Overexpressing Human Embryonic Kidney 293 Cells.
Topics: Animals; Arylsulfotransferase; Biological Transport; HEK293 Cells; Hesperidin; Humans; Liver; Multidrug Resistance-Associated Proteins; Rats; Sulfates | 2015 |
Single Dose Oral and Intravenous Pharmacokinetics and Tissue Distribution of a Novel Hesperetin Derivative MTBH in Rats.
Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Carbon Tetrachloride Poisoning; Dose-Response Relationship, Drug; Drug Stability; Glucuronides; Half-Life; Hesperidin; Injections, Intravenous; Male; Protective Agents; Random Allocation; Rats, Sprague-Dawley; Sulfates; Tissue Distribution | 2016 |
Hesperetin prevents selenite-induced cataract in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Cataract; Disease Models, Animal; Eye Proteins; Female; Free Radical Scavengers; Glutathione; Hesperidin; Intermediate Filament Proteins; Lens, Crystalline; Oxidative Stress; Proteolysis; Rats; Rats, Sprague-Dawley; Sodium Selenite | 2015 |
[Simultaneous determination of 11 constituents in Citrus reticulate 'Chachi' by high performance liquid chromatography].
Topics: Apigenin; Chromatography, High Pressure Liquid; Citrus; Flavones; Flavonoids; Furaldehyde; Glucosides; Hesperidin | 2015 |
Hesperetin Modifies the Composition of Fecal Microbiota and Increases Cecal Levels of Short-Chain Fatty Acids in Rats.
Topics: Animals; Bacteria; Cecum; Fatty Acids, Volatile; Feces; Gastrointestinal Microbiome; Hesperidin; Male; Rats; Rats, Wistar | 2015 |
Characterization of the antioxidant activity of aglycone and glycosylated derivatives of hesperetin: an in vitro and in vivo study.
Topics: Animals; Antioxidants; Gene Expression Regulation, Enzymologic; Hesperidin; In Vitro Techniques; Lipids; Liver; Male; Rats; Rats, Wistar; Superoxide Dismutase; Xanthine Oxidase | 2016 |
Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury.
Topics: Animals; Biomarkers; Blotting, Western; Disease Models, Animal; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Interleukin-1beta; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells; Retinal Vessels; Solubility; Water | 2016 |
Fisetin and hesperetin induced apoptosis and cell cycle arrest in chronic myeloid leukemia cells accompanied by modulation of cellular signaling.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Flavonoids; Flavonols; Gene Expression Regulation, Leukemic; Gene Regulatory Networks; Genome-Wide Association Study; Hesperidin; Humans; K562 Cells; Membrane Potential, Mitochondrial; Neoplasm Proteins | 2016 |
Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Esophageal Neoplasms; Female; Glutathione; Hesperidin; Humans; Mice; Mice, Inbred BALB C; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2016 |
Hesperetin and its sulfate and glucuronide metabolites inhibit TNF-α induced human aortic endothelial cell migration and decrease plasminogen activator inhibitor-1 (PAI-1) levels.
Topics: Aorta; Cell Line; Cell Movement; Citrus sinensis; Endothelial Cells; Fruit; Glucuronides; Hesperidin; Humans; Inflammation; Interleukin-6; Interleukin-8; Plasminogen Activator Inhibitor 1; Sulfates; Tumor Necrosis Factor-alpha | 2016 |
Scavenging of Toxic Acrolein by Resveratrol and Hesperetin and Identification of Adducts.
Topics: Acrolein; Antioxidants; Hesperidin; Hydrogen-Ion Concentration; Molecular Structure; Resveratrol; Stilbenes | 2015 |
Hesperetin Liposomes for Cancer Therapy.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cholesterol; Drug Compounding; Drug Resistance, Neoplasm; Female; Hesperidin; Humans; Kinetics; Liposomes; Lung Neoplasms; Phosphatidylcholines; Polyethylene Glycols; Solubility; Transfection | 2016 |
Hesperetin exerts apoptotic effect on A431 skin carcinoma cells by regulating mitogen activated protein kinases and cyclins.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Survival; Cyclins; Hesperidin; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Skin Neoplasms | 2015 |
Pharmacokinetic interaction study between flavanones (hesperetin, naringenin) and rasagiline mesylate in wistar rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cytochrome P-450 CYP1A2; Drug Interactions; Flavanones; Hesperidin; Indans; Male; Monoamine Oxidase Inhibitors; Rats, Wistar; Spinal Cord; Tissue Distribution | 2016 |
Antiproliferative and antioxidant potential of hesperetin against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Benzo(a)pyrene; Carcinogenesis; Cell Proliferation; Cytochrome P-450 CYP1A1; Hesperidin; Lipid Peroxidation; Lung; Male; Mice; NF-E2-Related Factor 2; NF-kappa B; Proliferating Cell Nuclear Antigen; Tumor Necrosis Factor-alpha | 2015 |
A HPLC-MS/MS method for the quantitation of free, conjugated, and total HDND-7, a novel hesperetin derivative, in rat plasma and tissues: Application to the pharmacokinetic and tissue distribution study.
Topics: Animals; Chromatography, High Pressure Liquid; Hesperidin; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution | 2016 |
Copper(II) complexes with naringenin and hesperetin: cytotoxic activity against A 549 human lung adenocarcinoma cells and investigation on the mode of action.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Coordination Complexes; Copper; DNA; Fibroblasts; Flavanones; Hesperidin; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms | 2016 |
Hesperetin attenuates ventilator-induced acute lung injury through inhibition of NF-κB-mediated inflammation.
Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Survival; Cytokines; Gene Expression Regulation; Hesperidin; Inflammation; Lung; Macrophages; Male; Peroxidase; PPAR gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Transcription Factor RelA; Ventilator-Induced Lung Injury | 2015 |
Simple low-cost miniaturization approach for pharmaceutical nanocrystals production.
Topics: Apigenin; Ascorbic Acid; Chemistry, Pharmaceutical; Cyclosporine; Hesperidin; Miniaturization; Nanoparticles; Particle Size; Resveratrol; Stilbenes; Suspensions; Technology, Pharmaceutical | 2016 |
Effects of hesperetin on platelet-derived growth factor-BB-induced pulmonary artery smooth muscle cell proliferation.
Topics: Animals; Becaplermin; Cell Proliferation; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hesperidin; Humans; Myocytes, Smooth Muscle; Oncogene Protein v-akt; Primary Cell Culture; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Rats; Signal Transduction | 2016 |
Host-guest system of hesperetin and β-cyclodextrin or its derivatives: Preparation, characterization, inclusion mode, solubilization and stability.
Topics: Cyclodextrins; Drug Stability; Hesperidin; Nuclear Magnetic Resonance, Biomolecular; Solubility | 2016 |
Biotransformation effects on anti lipogenic activity of citrus extracts.
Topics: Adipocytes; Animals; Citrus; Flavanones; Hesperidin; Lipolysis; Mice; Plant Extracts | 2016 |
Protective Effect of Oral Hesperetin Against Unilateral Striatal 6-Hydroxydopamine Damage in the Rat.
Topics: Administration, Oral; Animals; Apoptosis; Corpus Striatum; Glial Fibrillary Acidic Protein; Gliosis; Hesperidin; Male; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Oxidopamine; Parkinson Disease; Rats, Wistar | 2016 |
Simultaneous Chiral Separation of Flavanone, Naringenin, and Hesperetin Enantiomers by RP-UHPLC-DAD.
Topics: Amylose; Chromatography, High Pressure Liquid; Flavanones; Hesperidin; Molecular Structure; Phenylcarbamates; Stereoisomerism | 2016 |
The novel voltammetric method for determination of hesperetin based on a sensitive electrochemical sensor.
Topics: Calibration; Electrochemistry; Electrodes; Glass; Graphite; Hesperidin; Humans; Hydrogen-Ion Concentration; Limit of Detection; Nanotubes, Carbon; Oxidation-Reduction; Oxides; Reproducibility of Results; Time Factors | 2016 |
Hesperetin derivatives: Synthesis and anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Hesperidin; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2016 |
Isolation and characterization of wound-induced compounds from the leaves of Citrus hassaku.
Topics: Anti-Bacterial Agents; Citrus; Furans; Hesperidin; Lignans; Magnetic Resonance Spectroscopy; Plant Diseases; Plant Leaves; Spectrometry, Mass, Electrospray Ionization; Wounds and Injuries | 2016 |
Chemical Evidence for Potent Xanthine Oxidase Inhibitory Activity of Ethyl Acetate Extract of Citrus aurantium L. Dried Immature Fruits.
Topics: Acetates; Citrus; Enzyme Inhibitors; Flavanones; Flavones; Fruit; Hesperidin; Humans; Hyperuricemia; In Vitro Techniques; Molecular Structure; Phytotherapy; Plant Extracts; Xanthine Oxidase | 2016 |
Hesperetin Suppresses Inflammatory Responses in Lipopolysaccharide-Induced RAW 264.7 Cells via the Inhibition of NF-κB and Activation of Nrf2/HO-1 Pathways.
Topics: Animals; Enzyme Activation; Gene Expression Regulation; Heme Oxygenase-1; Hesperidin; Inflammation; Lipopolysaccharides; Mice; NF-E2-Related Factor 2; NF-kappa B; RAW 264.7 Cells | 2016 |
Enhanced anti-oxidative effect of fermented Korean mistletoe is originated from an increase in the contents of caffeic acid and lyoniresinol.
Topics: Animals; Anisoles; Antioxidants; Aspergillus; Benzaldehydes; Caffeic Acids; Cell Line; Chromatography, High Pressure Liquid; Fermentation; Free Radical Scavengers; Glutamic Acid; Herbal Medicine; Hesperidin; Mice; Mistletoe; Naphthalenes; Neuroprotective Agents; Plant Extracts; Solvents | 2016 |
Phytochemical analysis, antimicrobial, antioxidant activities and total phenols of Ferulago carduchorum in two vegetative stages (flower and fruit).
Topics: Anti-Infective Agents; Antioxidants; Apiaceae; Bacteria; Biphenyl Compounds; Flowers; Fruit; Fungi; Hesperidin; Microbial Sensitivity Tests; Phenols; Phytotherapy; Picrates; Plant Extracts; Plants, Medicinal; Solvents | 2016 |
Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model.
Topics: Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Proliferation; Cisplatin; Cochlea; Disease Models, Animal; Ear, Inner; Hearing Loss; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Injections, Intraperitoneal; Male; Otoacoustic Emissions, Spontaneous; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Signal-To-Noise Ratio; Spiral Ganglion | 2016 |
The individual or combinational effects of Hesperetin and Letrozole on the activity and expression of aromatase in MCF-7 cells.
Topics: Aromatase; Cell Survival; Enzyme Assays; Estradiol; Hesperidin; Humans; Letrozole; MCF-7 Cells; Nitriles; Real-Time Polymerase Chain Reaction; Triazoles | 2016 |
Role of hesperetin in LDL-receptor expression in hepatoma HepG2 cells.
Topics: Gene Expression; Hep G2 Cells; Hesperidin; Humans; Liver Neoplasms; Receptors, LDL; Sterol Regulatory Element Binding Proteins | 2016 |
Inhibitory effects of hesperetin on Kv1.5 potassium channels stably expressed in HEK 293 cells and ultra-rapid delayed rectifier K(+) current in human atrial myocytes.
Topics: Dose-Response Relationship, Drug; Electrophysiological Phenomena; Gene Expression; Heart Atria; HEK293 Cells; Hesperidin; Humans; Ion Channel Gating; Kinetics; Kv1.5 Potassium Channel; Myocytes, Cardiac; Potassium; Potassium Channel Blockers | 2016 |
Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors.
Topics: Cell Cycle; Cell Line, Tumor; Flavanones; Genes, erbB-2; Hesperidin; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases | 2016 |
Development and validation of a RP-UHPLC-ESI-MS/MS method for the chiral separation and determination of flavanone, naringenin and hesperetin enantiomers.
Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Flavanones; Hesperidin; Reproducibility of Results; Tandem Mass Spectrometry | 2016 |
Intestinal transport of HDND-7, a novel hesperetin derivative, in in vitro MDCK cell and in situ single-pass intestinal perfusion models.
Topics: Administration, Oral; Animals; Biological Availability; Biological Transport; Dogs; Hesperidin; Intestinal Mucosa; Madin Darby Canine Kidney Cells; Rats | 2017 |
Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats.
Topics: Aging; Animals; Antioxidants; Citrus; Flavanones; Gene Expression; Hesperidin; Lipid Peroxidation; Liver; Male; Oxidative Stress; Phospholipids; Plant Oils; Rats; Rats, Wistar; Sunflower Oil; Thiobarbituric Acid Reactive Substances | 2016 |
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro.
Topics: Animals; Biological Products; Concanavalin A; Dose-Response Relationship, Drug; Galactosamine; Hesperidin; In Vitro Techniques; Lipopolysaccharides; Liver Failure, Acute; Male; Protective Agents; Rats; Rats, Wistar | 2017 |
Antispasmodic effect of selected Citrus flavonoids on rat isolated jejunum specimens.
Topics: Animals; Citrus; Hesperidin; Jejunum; Male; Muscle Contraction; Rats; Rats, Wistar; Spasm | 2016 |
Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus.
Topics: Bifidobacterium longum; Citrus sinensis; Flavanones; Fruit; Fruit and Vegetable Juices; Glucosidases; Hesperidin; Intestinal Absorption; Lacticaseibacillus rhamnosus; Probiotics | 2018 |
Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats.
Topics: Acetylcholinesterase; Animals; Antioxidants; Apoptosis; Brain; Brain Chemistry; Cadmium; Hesperidin; Lipid Peroxidation; Male; Mitochondria; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar | 2017 |
Hesperitin derivative-11 suppress hepatic stellate cell activation and proliferation by targeting PTEN/AKT pathway.
Topics: Actins; Alanine Transaminase; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Aspartate Aminotransferases; Cell Line; Cell Proliferation; Collagen Type I; Collagen Type I, alpha 1 Chain; Hepatic Stellate Cells; Hesperidin; Liver Cirrhosis; Male; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Signal Transduction; Transforming Growth Factor beta1 | 2017 |
Synthesis and biological evaluation of hesperetin derivatives as agents inducing apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Caspase 3; Caspase 9; Colony-Forming Units Assay; HCT116 Cells; Hesperidin; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Molecular Docking Simulation; Molecular Structure; Poly (ADP-Ribose) Polymerase-1 | 2017 |
Chronic exposure to short-chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells.
Topics: Acetates; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Butyrates; Caco-2 Cells; Coumaric Acids; Fatty Acids, Volatile; Gastrointestinal Microbiome; Glucuronosyltransferase; Hesperidin; Humans; Intestinal Mucosa; Lactates; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasm Proteins; Polyphenols; Propionates; Symporters | 2017 |
Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions.
Topics: Animals; Cell Line; Citrus; Flavanones; Glucuronosyltransferase; Herb-Drug Interactions; Hesperidin; Humans; Hymecromone; Insecta; Recombinant Proteins; Trifluoperazine | 2016 |
Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism.
Topics: Anilides; Animals; Hesperidin; Humans; Male; Nitriles; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Tosyl Compounds | 2017 |
Hesperetin-etoposide combinations induce cytotoxicity in U2OS cells: Implications on therapeutic developments for osteosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cytotoxins; Doxorubicin; Etoposide; Hesperidin; Humans; Osteosarcoma | 2017 |
Hesperetin protects against H
Topics: Antioxidant Response Elements; Antioxidants; Cell Death; Cell Line; Epithelial Cells; Glutathione; Heme Oxygenase-1; Hesperidin; Humans; Hydrogen Peroxide; Kelch-Like ECH-Associated Protein 1; Malondialdehyde; NF-E2-Related Factor 2; Oxidative Stress; Protective Agents; RNA, Small Interfering; Signal Transduction; Superoxide Dismutase; Transfection; Up-Regulation | 2017 |
Structure-activity relationship of flavanone. Anti-degranulation activity of 7-O-substituted hesperetin.
Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Flavanones; Hesperidin; Rats; Structure-Activity Relationship | 2017 |
The renoprotective activity of hesperetin in cisplatin induced nephrotoxicity in rats: Molecular and biochemical evidence.
Topics: Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Cisplatin; Creatinine; Flavonoids; Hesperidin; Inflammation; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Oxidative Stress; Protective Agents; Rats; Rats, Wistar | 2017 |
Inhibitory effect of hesperetin on α-glucosidase: Molecular dynamics simulation integrating inhibition kinetics.
Topics: alpha-Glucosidases; Glycoside Hydrolase Inhibitors; Hesperidin; Kinetics; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Structure, Tertiary; Saccharomyces cerevisiae | 2017 |
Use of multiresponse statistical techniques to optimize the separation of diosmin, hesperidin, diosmetin and hesperitin in different pharmaceutical preparations by high performance liquid chromatography with UV-DAD.
Topics: Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Diosmin; Flavonoids; Hesperidin; Pharmaceutical Preparations; Solid Phase Microextraction; Ultraviolet Rays | 2017 |
Hesperetin-loaded lipid-core nanocapsules in polyamide: a new textile formulation for topical drug delivery.
Topics: Administration, Topical; Animals; Chromatography, High Pressure Liquid; Cotton Fiber; Drug Delivery Systems; Hesperidin; Humans; Lipids; Nanocapsules; Nylons; Skin Absorption; Sus scrofa | 2017 |
The effects of Nobiletin, Hesperetin, and Letrozole in a combination on the activity and expression of aromatase in breast cancer cells.
Topics: Aromatase; Aromatase Inhibitors; Estradiol; Flavones; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hesperidin; Humans; Immunoassay; Letrozole; MCF-7 Cells; Nitriles; Reverse Transcriptase Polymerase Chain Reaction; Triazoles | 2017 |
Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Diabetes Mellitus; Drug Design; Gluconeogenesis; Hesperidin; Inhibitory Concentration 50; Liver; Molecular Docking Simulation; Rats | 2017 |
The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration.
Topics: Animals; Apoptosis; Bone Regeneration; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Hesperidin; Humans; Male; Mesenchymal Stem Cells; Osteogenesis; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Tissue Engineering | 2017 |
Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Hesperidin; Inflammation; Janus Kinase 1; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; PPAR gamma; Random Allocation; RAW 264.7 Cells; Silymarin; STAT1 Transcription Factor | 2017 |
Is Failure of Cocrystallization Actually a Failure? Eutectic Formation in Cocrystal Screening of Hesperetin.
Topics: Animals; Antioxidants; Crystallization; Erythrocytes; Hemolysis; Hesperidin; Models, Molecular; Powder Diffraction; Protective Agents; Rats; Solubility; Thermodynamics; X-Ray Diffraction | 2017 |
Molecular effects of hesperetin, a citrus flavanone on7,12-dimethylbenz(a)anthracene induced buccal pouch squamous cell carcinoma in golden Syrian hamsters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cheek; Citrus; Cricetinae; Flavanones; Hesperidin; Immunoenzyme Techniques; Lipid Peroxidation; Male; Mesocricetus; Mouth Neoplasms | 2017 |
Bacterial Biosensors for in Vivo Spatiotemporal Mapping of Root Secretion.
Topics: Biosensing Techniques; Colony Count, Microbial; Gene Expression Regulation, Plant; Hesperidin; Image Processing, Computer-Assisted; Luminescence; Metabolome; Nitrogen Fixation; Pisum sativum; Plant Exudates; Plant Root Nodulation; Plant Roots; Rhizobium leguminosarum; Rhizosphere; Root Nodules, Plant; Symbiosis; Time Factors; Vicia | 2017 |
Hesperetin post-treatment prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating PI3K/Akt signaling pathway.
Topics: Animals; Apoptosis; Cardiotonic Agents; Caspase 3; Cell Survival; Hesperidin; Hypoxia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2017 |
Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53- independent pathway in human lung cancer H522 cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemoprevention; Gene Expression; Hesperidin; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial | 2018 |
Protective effect of hesperetin against haloperidol-induced orofacial dyskinesia and catalepsy in rats.
Topics: Animals; Behavior, Animal; Brain; Catalepsy; Dopamine; Dyskinesia, Drug-Induced; Dyskinesias; Glutathione; Haloperidol; Hesperidin; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Serotonin; Superoxide Dismutase | 2018 |
Design, Synthesis and Evaluation of Hesperetin Derivatives as Potential Multifunctional Anti-Alzheimer Agents.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Antioxidants; Catalytic Domain; Cell Line; Drug Design; GPI-Linked Proteins; Hesperidin; Humans; Hydrogen Peroxide; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Neuroprotective Agents; PC12 Cells; Protein Aggregates; Rats; Structure-Activity Relationship | 2017 |
Immunomodulatory potential of hesperetin and chrysin through the cellular and humoral response.
Topics: Animals; Cell Proliferation; Flavonoids; Hesperidin; Humans; Immunity, Cellular; Immunity, Humoral; Immunologic Factors; Intracellular Membranes; K562 Cells; Macrophages, Peritoneal; Male; Natural Killer T-Cells; Nitric Oxide; Permeability; Rats; Rats, Wistar; Spleen; T-Lymphocytes, Cytotoxic | 2017 |
Urinary metabolite profiling of flavonoids in Chinese volunteers after consumption of orange juice by UFLC-Q-TOF-MS/MS.
Topics: Adult; China; Chromatography, High Pressure Liquid; Citrus sinensis; Female; Flavanones; Flavonoids; Fruit and Vegetable Juices; Hesperidin; Humans; Male; Tandem Mass Spectrometry; Young Adult | 2017 |
Design, synthesis and biological evaluation of hesperetin derivatives as potent anti-inflammatory agent.
Topics: Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Hesperidin; Interleukin-6; Liver; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide; RAW 264.7 Cells; Tumor Necrosis Factor-alpha | 2017 |
Production of drug nanosuspensions: effect of drug physical properties on nanosizing efficiency.
Topics: Calorimetry, Differential Scanning; Crystallization; Desiccation; Glyburide; Hesperidin; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Powder Diffraction; Quercetin; Resveratrol; Rutin; Stilbenes; Technology, Pharmaceutical | 2018 |
Chitosan-based nano-formulation enhances the anticancer efficacy of hesperetin.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chitosan; Drug Delivery Systems; Drug Liberation; Gene Expression Regulation, Neoplastic; Hesperidin; Humans; Nanoparticles; Particle Size; Powders; Spectroscopy, Fourier Transform Infrared; Static Electricity; X-Ray Diffraction | 2018 |
Preventive effect of hesperidin modulates inflammatory responses and antioxidant status following acute myocardial infarction through the expression of PPAR‑γ and Bcl‑2 in model mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; bcl-2-Associated X Protein; Cardiotonic Agents; Caspase 9; Chemokine CCL2; Creatine Kinase, MB Form; Drug Evaluation, Preclinical; Hesperidin; Intercellular Adhesion Molecule-1; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53 | 2018 |
Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hesperidin; Hippocampus; Male; Malondialdehyde; Memory Disorders; Nanoparticles; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2018 |
Chemical constituents from the flowers of Satsuma mandarin and their free radical scavenging and
Topics: Citrus; Drug Evaluation, Preclinical; Flavonoids; Flowers; Free Radical Scavengers; Glycoside Hydrolase Inhibitors; Hesperidin; Japan; Magnetic Resonance Spectroscopy; Molecular Structure; Phenols; Plants, Medicinal; Quercetin; Rutin | 2019 |
Citrus bioflavonoid, hesperetin, as inhibitor of two thrombin-like snake venom serine proteases isolated from Crotalus simus.
Topics: Animals; Crotalid Venoms; Crotalus; Fibrinolysis; Hesperidin; Humans; Kinetics; Molecular Docking Simulation; Protein Conformation; Sequence Analysis, Protein; Serine Proteases; Tandem Mass Spectrometry | 2018 |
Topics: Antioxidants; Apiaceae; Cinnamates; Depsides; Hesperidin; Iran; Phenols; Plant Extracts; Polyphenols; Rosmarinic Acid | 2019 |
The acute effects of citrus flavanones on the metabolism of glycogen and monosaccharides in the isolated perfused rat liver.
Topics: Adenosine Diphosphate; Animals; Citrus; Energy Metabolism; Flavanones; Flavones; Fructose; Glucose; Glycogenolysis; Hesperidin; In Vitro Techniques; Liver; Liver Glycogen; Male; Monosaccharides; Oxygen Consumption; Perfusion; Rats; Rats, Wistar | 2018 |
Magnetic molecularly imprinted polymer for the selective extraction of hesperetin from the dried pericarp of Citrus reticulata Blanco.
Topics: Citrus; Fruit; Hesperidin; Magnetite Nanoparticles; Molecular Imprinting; Molecular Structure; Particle Size; Polymers; Surface Properties | 2018 |
Nanocrystals for improved dermal drug delivery.
Topics: Administration, Cutaneous; Biological Availability; Chemistry, Pharmaceutical; Drug Compounding; Drug Delivery Systems; Excipients; Hesperidin; Hydrogels; Nanoparticles; Organic Chemicals; Rutin; Skin Absorption; Solubility | 2018 |
Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Enzyme Activation; Enzyme Inhibitors; Hesperidin; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Molecular; Neurons; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt | 2018 |
The citrus flavonone hesperetin attenuates the nuclear translocation of aryl hydrocarbon receptor.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Active Transport, Cell Nucleus; Antineoplastic Agents, Phytogenic; Basic Helix-Loop-Helix Transcription Factors; Breast Neoplasms; Carcinogens, Environmental; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Dietary Supplements; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Hesperidin; Humans; MCF-7 Cells; Microscopy, Confocal; Neoplasm Proteins; Polychlorinated Dibenzodioxins; Receptors, Aryl Hydrocarbon | 2018 |
Metabolism of Phenolic Compounds in LPS-stimulated Raw264.7 Cells Can Impact Their Anti-inflammatory efficacy: Indication of Hesperetin.
Topics: Animals; Anti-Inflammatory Agents; Hesperidin; Lipopolysaccharides; Macrophages; Mice; Phenols; RAW 264.7 Cells | 2018 |
Effect of hesperetin derivatives on the development of selenite‑induced cataracts in rats.
Topics: Animals; Ascorbic Acid; Cataract; Female; Glutathione; Hesperidin; Rats; Rats, Sprague-Dawley; Selenious Acid | 2018 |
Design, synthesis and investigation of potential anti-inflammatory activity of O-alkyl and O-benzyl hesperetin derivatives.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hesperidin; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred Strains; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; RAW 264.7 Cells; Signal Transduction; Structure-Activity Relationship | 2018 |
Hesperetin Mitigates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting Extracellular Matrix and Cell Apoptosis via the TGF-β1/Smad Pathway.
Topics: Animals; Apoptosis; Disease Models, Animal; Extracellular Matrix; Hesperidin; Interleukin-6; Liver Cirrhosis; Male; Mice; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha | 2018 |
High throughput screening of mitochondrial bioenergetics in human differentiated myotubes identifies novel enhancers of muscle performance in aged mice.
Topics: Adenosine Triphosphate; Animals; Cell Differentiation; Energy Metabolism; Hesperidin; Humans; Membrane Potential, Mitochondrial; Mice; Mitochondria; Muscle Fibers, Skeletal; Muscle, Skeletal; Oxidative Stress | 2018 |
In Silico Docking and In Vitro Approaches towards BACE1 and Cholinesterases Inhibitory Effect of Citrus Flavanones.
Topics: Acetylcholinesterase; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Citrus; Enzyme Assays; Flavanones; GPI-Linked Proteins; Hesperidin; Humans; Kinetics; Molecular Docking Simulation; Neuroprotective Agents; Nootropic Agents; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Thermodynamics | 2018 |
Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido-inflammatory stress in rat model of autism.
Topics: Animals; Anticonvulsants; Antioxidants; Autistic Disorder; Birth Weight; Brain Chemistry; Cytokines; Female; Hesperidin; Inflammation; Interpersonal Relations; Motor Activity; Nanoparticles; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Social Behavior; Valproic Acid | 2018 |
Synthesis of hesperetin-loaded PLGA nanoparticles by two different experimental design methods and biological evaluation of optimized nanoparticles.
Topics: Animals; Anti-Bacterial Agents; Biocompatible Materials; Cell Line; Cell Survival; Chemistry, Pharmaceutical; Escherichia coli; Hesperidin; Lactic Acid; Mice; Microbial Sensitivity Tests; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Regression Analysis; Staphylococcus aureus | 2018 |
Hesperetin reduces myelin damage and ameliorates glial activation in lysolecithin-induced focal demyelination model of rat optic chiasm.
Topics: Animals; Antioxidants; Citrus; Demyelinating Diseases; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Lysophosphatidylcholines; Male; Multiple Sclerosis; Myelin Sheath; Neuroglia; Optic Chiasm; Rats; Rats, Wistar | 2018 |
Solid Dispersion of Hesperetin Co-crystals Synergistically Attenuates Hepatic Toxicity of Carbon Tetrachloride Oxidative Stress in Rats.
Topics: Animals; Biological Availability; Carbon Tetrachloride; Crystallization; Hesperidin; Liver; Oxidative Stress; Particle Size; Rats; Solubility; Surface Properties | 2018 |
Beneficial Effects of Hesperetin in a Mouse Model of Temporal Lobe Epilepsy.
Topics: Administration, Oral; Animals; Anticonvulsants; Citrus; Disease Models, Animal; Epilepsy, Temporal Lobe; Fruit; Hesperidin; Kainic Acid; Male; Mice; Phytotherapy | 2018 |
Hesperetin, a citrus flavonoid, attenuates testicular damage in diabetic rats via inhibition of oxidative stress, inflammation, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cells, Cultured; Citrus; Diabetes Mellitus, Experimental; Flavonoids; Hesperidin; Inflammation; Male; Oxidative Stress; Rats; Rats, Wistar; Testicular Diseases | 2018 |
Insecticidal effects of the Olea europaea subsp. laperrinei extracts on the flour Pyralid Ephestia kuehniella.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Hesperidin; Insecticides; Iridoid Glucosides; Iridoids; Larva; Moths; Olea; Phenylethyl Alcohol; Plant Extracts; Plant Leaves; Quercetin | 2018 |
Effect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid-induced experimental colitis model.
Topics: Animals; Antioxidants; Colitis; Enzyme-Linked Immunosorbent Assay; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Lipid Peroxidation; Male; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Pharmacokinetic study of the prokinetic ABCs liquiritigenin, naringenin and hesperitin following the oral administration of Si-Ni-San decoction to functional dyspepsia patients.
Topics: Administration, Oral; Adult; Chromatography, Liquid; Drugs, Chinese Herbal; Dyspepsia; Female; Flavanones; Gastrointestinal Motility; Hesperidin; Humans; Male; Middle Aged; Sulfamethoxazole | 2019 |
Inhibition of Atherosclerotic Plaque Development by Oral Administration of α-Glucosyl Hesperidin and Water-Dispersible Hesperetin in Apolipoprotein E Knockout Mice.
Topics: Administration, Oral; Animals; Antioxidants; Apolipoproteins E; Cholesterol; Diet, High-Fat; Glucosides; Hesperidin; Male; Mice; Mice, Knockout; Plaque, Atherosclerotic | 2019 |
Hesperetin mitigates acrolein-induced apoptosis in lung cells in vitro and in vivo.
Topics: Acrolein; Animals; Antioxidants; Apoptosis; Cell Line, Tumor; Hesperidin; Mice; Oxidative Stress; Reactive Oxygen Species | 2018 |
Antioxidant hesperetin improves the quality of porcine oocytes during aging in vitro.
Topics: Animals; Blastocyst; Cellular Senescence; Embryonic Development; Hesperidin; Oocytes; Oxidative Stress; Reactive Oxygen Species; Swine | 2019 |
Immunohistochemical examination of anti-inflammatory and anti-apoptotic effects of hesperetin on trinitrobenzene sulfonic acid induced colitis in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Colitis; Gene Expression Regulation; Hesperidin; Immunohistochemistry; Inflammation; Leukocyte Common Antigens; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2019 |
Suppression of Taxanes Cytotoxicity by Citrus Flavonoid Hesperetin in PPC-1 Human Prostate Cancer Cells.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Dietary Supplements; Docetaxel; Drug Antagonism; Hesperidin; Humans; Male; Prostatic Neoplasms; Taxoids | 2018 |
Sulfation of hesperetin, naringenin and apigenin by the human cytosolic sulfotransferases: a comprehensive analysis.
Topics: Apigenin; Cell Line, Tumor; Cytosol; Flavanones; Hesperidin; Humans; Intestinal Mucosa; Kidney; Liver; Lung; Metabolic Networks and Pathways; Sulfates; Sulfotransferases | 2020 |
Optimization of Regioselective α-Glucosylation of Hesperetin Catalyzed by Cyclodextrin Glucanotransferase.
Topics: Catalysis; Chromatography, High Pressure Liquid; Glucosyltransferases; Glycosylation; Hesperidin; Mass Spectrometry; Molecular Structure | 2018 |
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Topics: Animals; Cell Proliferation; Gene Expression Regulation; Genes, fos; Hesperidin; Humans; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinases; Molecular Structure; NF-kappa B; NFATC Transcription Factors; Osteogenesis; Osteoporosis; RANK Ligand; RAW 264.7 Cells | 2019 |
Nanocrystalline solid dispersions (NSD) of hesperetin (HRN) for prevention of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in Sprague-Dawley (SD) rats.
Topics: Animals; Anthracenes; Female; Hesperidin; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Nanoparticles; Piperidines; Random Allocation; Rats; Rats, Sprague-Dawley | 2019 |
The citrus flavanone hesperetin preferentially inhibits slow-inactivating currents of a long QT syndrome type 3 syndrome Na
Topics: Animals; Aorta, Abdominal; Cardiac Conduction System Disease; Cardiotonic Agents; Citrus; Heart; HEK293 Cells; Hesperidin; Humans; Long QT Syndrome; Male; Models, Molecular; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Rats, Wistar; Vasodilator Agents | 2019 |
Modulating effect of hesperetin on the molecular expression pattern of apoptotic and cell proliferative markers in 7,12-dimethylbenz(a)anthracene-induced oral carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Biomarkers, Tumor; Carcinogens; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hesperidin; Male; Mesocricetus; Mouth Neoplasms; Protective Agents | 2020 |
Comparative evaluation of hesperetin loaded nanoparticles for anticancer activity against C6 glioma cancer cells.
Topics: Antineoplastic Agents; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Carriers; Glioma; Glutathione; Hesperidin; Humans; Malondialdehyde; Nanoparticles; Oxidative Stress; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Superoxide Dismutase | 2019 |
Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Astrocytes; Biomarkers; Cell Line; Cognitive Dysfunction; Disease Models, Animal; Hesperidin; Hippocampus; Male; Memory; Memory Disorders; Mice, Inbred C57BL; Microglia; Nerve Tissue Proteins; Neuroprotection; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Signal Transduction; Synapses; Toll-Like Receptor 4 | 2019 |
Hesperetin derivative-12 (HDND-12) regulates macrophage polarization by modulating JAK2/STAT3 signaling pathway.
Topics: Animals; Cytokines; Enzyme Inhibitors; Gene Expression Regulation; Hesperidin; Inflammation; Janus Kinase 2; Macrophages; Medicine, Chinese Traditional; Mice; Molecular Structure; Phosphorylation; RAW 264.7 Cells; Signal Transduction; STAT3 Transcription Factor | 2019 |
Protective effects of hesperetin on lipopolysaccharide-induced acute lung injury by targeting MD2.
Topics: Acute Lung Injury; Animals; Cytoprotection; Gene Expression Regulation; Hesperidin; Humans; Lipopolysaccharides; Lung; Lymphocyte Antigen 96; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Targeted Therapy; Protein Conformation; RAW 264.7 Cells; Toll-Like Receptor 4 | 2019 |
Hesperetin and Hesperidin Improved β-Carotene Incorporation Efficiency, Intestinal Cell Uptake, and Retinoid Concentrations in Tissues.
Topics: Animals; beta Carotene; Biological Availability; Biological Transport; Caco-2 Cells; Citrus; Hesperidin; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Retinoids | 2019 |
Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway.
Topics: Animals; Carboxylic Ester Hydrolases; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glutamate-Cysteine Ligase; Glycation End Products, Advanced; Hesperidin; Inflammation; Kidney; Lactoylglutathione Lyase; Male; NF-E2-Related Factor 2; Protective Agents; Rats; Rats, Sprague-Dawley; Signal Transduction; Streptozocin; Up-Regulation | 2019 |
Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling.
Topics: Animals; Apoptosis; Citrus; Hesperidin; Hippocampus; Lipopolysaccharides; Male; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Neuritis; Neuroprotective Agents; NF-kappa B; Oxidative Stress; Signal Transduction; Toll-Like Receptor 4 | 2019 |
Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.
Topics: Animals; Bone Marrow Cells; Cell- and Tissue-Based Therapy; Diabetes Mellitus, Type 2; Disease Models, Animal; Endoribonucleases; Gene Knock-In Techniques; Gene Transfer Techniques; Hesperidin; Lactoylglutathione Lyase; Mice; Neovascularization, Physiologic; Protein Serine-Threonine Kinases; Pyruvaldehyde; Resveratrol; Skin; Stem Cells; Wound Healing; Wounds and Injuries | 2019 |
Combination of hesperetin and platinum enhances anticancer effect on lung adenocarcinoma.
Topics: A549 Cells; Adenocarcinoma of Lung; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Disease Progression; Glucuronosyltransferase; Hesperidin; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Platinum Compounds; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2019 |
Targeted delivery of hesperetin to cartilage attenuates osteoarthritis by bimodal imaging with Gd
Topics: Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Down-Regulation; Drug Delivery Systems; Gadolinium; Hesperidin; Inflammation; Interleukin-1beta; Male; Mice, Inbred C57BL; Nanoparticles; NF-kappa B; Osteoarthritis; Peptides; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Toll-Like Receptor 2 | 2019 |
The Scalability of Wet Ball Milling for The Production of Nanosuspensions.
Topics: Curcumin; Drug Compounding; Excipients; Hesperidin; Nanoparticles; Poloxamer; Sodium Cholate; Suspensions; Technology, Pharmaceutical | 2019 |
Cortico-hippocampal memory enhancing activity of hesperetin on scopolamine-induced amnesia in mice: role of antioxidant defense system, cholinergic neurotransmission and expression of BDNF.
Topics: Acetylcholinesterase; Amnesia; Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cholinergic Neurons; Hesperidin; Hippocampus; Maze Learning; Memory; Mice; Neuroprotective Agents; Oxidative Stress; Scopolamine; Synaptic Transmission | 2019 |
Combined administration of naringenin and hesperetin with optimal ratio maximizes the anti-cancer effect in human pancreatic cancer via down regulation of FAK and p38 signaling pathway.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Citrus; Down-Regulation; Flavanones; Focal Adhesion Kinase 1; Hesperidin; Humans; MAP Kinase Signaling System; Mice, Inbred BALB C; Pancreatic Neoplasms; Phosphorylation; Xenograft Model Antitumor Assays | 2019 |
A hesperetin derivative plays a role in immunoregulatory effect on human macrophages.
Topics: bcl-X Protein; Cell Proliferation; Cell Survival; Hesperidin; Humans; Immunologic Factors; Interleukin-1beta; Interleukin-6; Macrophages; Nitric Oxide; Phagocytosis; THP-1 Cells | 2019 |
Hesperetin is a potent bioactivator that activates SIRT1-AMPK signaling pathway in HepG2 cells.
Topics: AMP-Activated Protein Kinases; Carbazoles; Hep G2 Cells; Hesperidin; Humans; Phosphorylation; Resveratrol; Signal Transduction; Sirtuin 1 | 2019 |
Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Cell Line; Cell Survival; Cisplatin; Creatinine; Hesperidin; Humans; Inflammation; Kidney; Mice; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction | 2019 |
Preparation of restricted access molecularly imprinted polymers based fiber for selective solid-phase microextraction of hesperetin and its metabolites in vivo.
Topics: Hesperidin; Molecular Imprinting; Polymers; Solid Phase Microextraction | 2019 |
Hesperetin Induces Apoptosis in Human Glioblastoma Cells via p38 MAPK Activation.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; G2 Phase Cell Cycle Checkpoints; Glioblastoma; Hesperidin; Humans; p38 Mitogen-Activated Protein Kinases | 2020 |
High level production of flavonoid rhamnosides by metagenome-derived Glycosyltransferase C in Escherichia coli utilizing dextrins of starch as a single carbon source.
Topics: Bacterial Proteins; Dextrins; Escherichia coli; Glycosyltransferases; Hesperidin; Metagenome; Microorganisms, Genetically-Modified | 2019 |
Synthesis of Daidzein Glycosides, α-Tocopherol Glycosides, Hesperetin Glycosides by Bioconversion and Their Potential for Anti-Allergic Functional-Foods and Cosmetics.
Topics: alpha-Tocopherol; Animals; Anti-Allergic Agents; Biocatalysis; Cell Culture Techniques; Cosmetics; Functional Food; Glycosides; Glycosylation; Hesperidin; Humans; Isoflavones; Male; Mast Cells; Monophenol Monooxygenase; Nicotiana; Plant Cells; Primary Cell Culture; Rats; Rats, Wistar; Solubility | 2019 |
Enzyme-assisted biotransformation increases hesperetin content in citrus juice by-products.
Topics: Antioxidants; Biodegradation, Environmental; Carboxylic Ester Hydrolases; Citrus; Glycoside Hydrolases; Hesperidin; Hydrolysis; Industrial Waste; Phenols | 2019 |
Hesperetin derivative attenuates CCl
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytokines; Hepatic Stellate Cells; Hesperidin; Humans; Liver Cirrhosis; Macrophages; Male; Mice, Inbred C57BL; Protective Agents; Transforming Growth Factor beta1; Zinc Finger Protein GLI1 | 2019 |
Boronic-targeted albumin-shell oily-core nanocapsules for synergistic aromatase inhibitor/herbal breast cancer therapy.
Topics: Albumins; Androstadienes; Antineoplastic Agents, Phytogenic; Aromatase Inhibitors; Boron; Breast Neoplasms; Female; Hesperidin; Humans; MCF-7 Cells; Nanocapsules; Phospholipids | 2019 |
Design, Synthesis and Investigation of the Potential Anti-Inflammatory Activity of 7-
Topics: Animals; Celecoxib; Cyclooxygenase 2; Gene Expression Regulation; Hesperidin; Humans; Hydrophobic and Hydrophilic Interactions; Indomethacin; Inflammation; Interleukin-1beta; Interleukin-6; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Signal Transduction; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2019 |
Comprehensive bioinformatics study reveals targets and molecular mechanism of hesperetin in overcoming breast cancer chemoresistance.
Topics: Breast Neoplasms; Cell Line, Tumor; Computational Biology; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Ontology; Hesperidin; Humans; Molecular Docking Simulation; Protein Kinase Inhibitors; Signal Transduction | 2020 |
Protective role of hesperetin against posttranslational oxidation of tryptophan residue of human γD-crystallin: A molecular level study.
Topics: gamma-Crystallins; Hesperidin; Humans; Models, Molecular; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Tryptophan | 2020 |
The Anti-Aging Potential of Neohesperidin and Its Synergistic Effects with Other Citrus Flavonoids in Extending Chronological Lifespan of
Topics: Antioxidants; Citrus; Dose-Response Relationship, Drug; Drug Synergism; Flavonoids; Hesperidin; Microbial Viability; Plant Extracts; Reactive Oxygen Species; Saccharomyces cerevisiae | 2019 |
Urinary flavanone concentrations as biomarkers of dietary flavanone intakes in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Topics: Biomarkers; Citrus sinensis; Diet; Europe; Female; Flavanones; Hesperidin; Humans; Male; Middle Aged; Nutrition Assessment; Nutrition Surveys | 2020 |
Hesperetin ameliorates lipopolysaccharide-induced acute lung injury in mice through regulating the TLR4-MyD88-NF-κB signaling pathway.
Topics: Acute Lung Injury; Animals; Dose-Response Relationship, Drug; Hesperidin; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Effect of hesperetin on systemic inflammation and hepatic injury after blunt chest trauma in rats.
Topics: Animals; Apoptosis; Hesperidin; Inflammation; Liver; Liver Diseases; Rats; Wounds and Injuries | 2020 |
Hesperetin as an adjuvant augments protective anti-tumour immunity responses in B16F10 melanoma by stimulating cytotoxic CD8
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Cancer Vaccines; CD8-Positive T-Lymphocytes; Female; Hesperidin; Melanoma, Experimental; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Skin Neoplasms | 2020 |
Hesperetin ameliorates DSS-induced colitis by maintaining the epithelial barrier via blocking RIPK3/MLKL necroptosis signaling.
Topics: Animals; Caco-2 Cells; Cell Membrane Permeability; Colitis; Cytokines; Dextran Sulfate; Epithelium; Hesperidin; Humans; Mice; Mice, Inbred C57BL; Necroptosis; Protein Kinases; RAW 264.7 Cells; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction | 2020 |
Neuro-protective effects of nano-formulated hesperetin in a traumatic brain injury model of
Topics: Animals; Brain Injuries, Traumatic; Hesperidin; Humans; Spectroscopy, Fourier Transform Infrared; Zebrafish | 2022 |
Hesperetin reverses P‑glycoprotein‑mediated cisplatin resistance in DDP‑resistant human lung cancer cells via modulation of the nuclear factor‑κB signaling pathway.
Topics: A549 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B; Cisplatin; Drug Resistance, Neoplasm; Hesperidin; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Proteins; Signal Transduction; Transcription Factor RelA | 2020 |
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Topics: Aged; Animals; Cells, Cultured; Chondrocytes; Female; Hesperidin; Humans; Interleukin-1beta; Male; Medial Collateral Ligament, Knee; Mice; Mice, Inbred C57BL; Middle Aged; NF-E2-Related Factor 2; NF-kappa B; Osteoarthritis; Protective Agents; Signal Transduction | 2020 |
The Citrus Flavanone Hesperetin Induces Apoptosis in CTCL Cells
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; Cell Survival; Citrus; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hesperidin; Humans; Molecular Structure; NF-kappa B; Receptor, Notch1; Signal Transduction; STAT3 Transcription Factor; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Insights into Interactions of Flavanones with Target Human Respiratory Syncytial Virus M
Topics: Antiviral Agents; Binding Sites; Hesperidin; Molecular Docking Simulation; Protein Binding; Viral Proteins | 2020 |
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression.
Topics: Acetaminophen; Animals; Apoptosis; Cell Death; Cell Line; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Heme Oxygenase-1; Hepatocytes; Hesperidin; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; Necrosis; Oxidative Stress; Transaminases; Up-Regulation | 2020 |
Hesperetin alleviated glucocorticoid-induced inhibition of osteogenic differentiation of BMSCs through regulating the ERK signaling pathway.
Topics: Butadienes; Cell Differentiation; Dexamethasone; Extracellular Signal-Regulated MAP Kinases; Glucocorticoids; Hesperidin; Humans; MAP Kinase Signaling System; Mesenchymal Stem Cells; Nitriles; Osteogenesis; Osteoporosis; Primary Cell Culture | 2021 |
Biochemical and genotoxic biomarkers and cell cycle assessment in the zebrafish liver (ZF-L) cell line exposed to the novel metal-insecticide magnesium-hespiridin complex.
Topics: Animals; Antioxidants; Cell Cycle; Cell Line; DNA Damage; Dose-Response Relationship, Drug; Ecotoxicology; Environmental Biomarkers; Glutathione; Hesperidin; Insecticides; Lipid Peroxidation; Liver; Magnesium; Mutagenicity Tests; Oxidative Stress; Reactive Oxygen Species; Water Pollutants, Chemical; Zebrafish | 2020 |
Hesperetin inhibit EMT in TGF-β treated podocyte by regulation of mTOR pathway.
Topics: Cell Death; Epithelial-Mesenchymal Transition; Hesperidin; Humans; Podocytes; Signal Transduction; Smad Proteins; TOR Serine-Threonine Kinases; Transforming Growth Factor beta | 2020 |
Cytotoxic and Antimetastatic Activity of Hesperetin and Doxorubicin Combination Toward Her2 Expressing Breast Cancer Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Movement; Cell Proliferation; Doxorubicin; Female; Hesperidin; Humans; Receptor, ErbB-2; Tumor Cells, Cultured | 2020 |
Double-Interface Binding of Two Bioactive Compounds with Cage-Like Ferritin.
Topics: Ferritins; Hesperidin; Hydrogen-Ion Concentration | 2020 |
The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na
Topics: Anti-Arrhythmia Agents; Cardiac Conduction System Disease; Cells, Cultured; Citrus; Dose-Response Relationship, Drug; HEK293 Cells; Hesperidin; Humans; Long QT Syndrome; Mutation; NAV1.5 Voltage-Gated Sodium Channel | 2020 |
Comparative Pharmacokinetic Study of Hesperetin after Oral Administration in Normal and Hyperuricemia Rats by UPLC-MS/MS.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Chromatography, Liquid; Hesperidin; Hyperuricemia; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2021 |
Mechanisms of Neuroprotective Action of Hesperetin and Carnosine in Focal Ischemia of the Brain in Rats.
Topics: Animals; Brain; Brain Ischemia; Carnosine; Hesperidin; Male; Neuroprotective Agents; Rats; Rats, Wistar | 2020 |
Hesperetin ameliorates lipopolysaccharide-induced acute lung injury via the miR-410/SOX18 axis.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Cytokines; Enzyme-Linked Immunosorbent Assay; Hesperidin; Inflammation Mediators; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; MicroRNAs; SOXF Transcription Factors | 2020 |
Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression Regulation; Gene Silencing; Heat-Shock Proteins; Hepatocytes; Hesperidin; Male; Palmitates; Rats; Rats, Wistar; RNA, Small Interfering; Signal Transduction | 2020 |
Neuroinflammation and Neurodegeneration: The Promising Protective Role of the Citrus Flavanone Hesperetin.
Topics: Anti-Inflammatory Agents; Antioxidants; Beverages; Citrus; Diet; Flavanones; Hesperidin; Humans; Inflammation; Neurodegenerative Diseases | 2020 |
Nano-hesperetin enhances the functional recovery and endogenous remyelination of the optic pathway in focal demyelination model.
Topics: Animals; Demyelinating Diseases; Disease Models, Animal; Evoked Potentials, Visual; Hesperidin; Male; Optic Chiasm; Rats; Rats, Wistar; Recovery of Function; Remyelination; Visual Cortex; Visual Pathways | 2020 |
Targeting the Nrf2/ARE Signalling Pathway to Mitigate Isoproterenol-Induced Cardiac Hypertrophy: Plausible Role of Hesperetin in Redox Homeostasis.
Topics: Animals; Antioxidants; Biomarkers; Cardiomegaly; Cell Line; Cell Nucleus; Cytoprotection; Gene Expression Regulation; Hesperidin; Homeostasis; Isoproterenol; Male; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Protein Transport; Rats, Wistar; RNA, Messenger; Signal Transduction; Superoxides | 2020 |
Hesperetin, a SIRT1 activator, inhibits hepatic inflammation via AMPK/CREB pathway.
Topics: Acetylation; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Enzyme Activation; Galactosamine; HEK293 Cells; Hesperidin; Humans; Liver; Macrophages; Male; Mice; Mice, Inbred BALB C; Protein Processing, Post-Translational; RAW 264.7 Cells; Signal Transduction; Sirtuin 1; Transcription Factor RelA | 2020 |
Hesperetin targets the hydrophobic pocket of the nucleoprotein/phosphoprotein binding site of human respiratory syncytial virus.
Topics: Binding Sites; Child; Hesperidin; Humans; Molecular Docking Simulation; Nucleoproteins; Phosphoproteins; Protein Binding; Respiratory Syncytial Virus, Human | 2022 |
Preparation and in vitro/in vivo evaluations of novel ocular micelle formulations of hesperetin with glycyrrhizin as a nanocarrier.
Topics: Administration, Ophthalmic; Animals; Biological Availability; Cornea; Corneal Ulcer; Drug Carriers; Drug Delivery Systems; Eye Infections, Bacterial; Glycyrrhizic Acid; Hesperidin; Micelles; Microscopy, Electron, Transmission; Nanoparticles; Ophthalmic Solutions; Particle Size; Pharmaceutical Preparations; Rabbits; Staphylococcal Infections; Surface Properties | 2021 |
Estimated dietary polyphenol intake and major food sources of the Brazilian population.
Topics: Beverages; Brazil; Chlorogenic Acid; Cross-Sectional Studies; Diet; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Polyphenols | 2021 |
Urinary Biomarkers for Orange Juice Consumption.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Citrus sinensis; Female; Flavanones; Fruit and Vegetable Juices; Hesperidin; Humans; Limit of Detection; Male; Phloretin; Proline; Reproducibility of Results; Synephrine; Tandem Mass Spectrometry; Urinalysis; Young Adult | 2021 |
Biological evaluation of 7-O-amide hesperetin derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amides; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cholinesterase Inhibitors; Hesperidin; Inflammation; Ligands; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Peptide Fragments; Protein Aggregates; Rats | 2021 |
Short-Term Intake of Hesperetin-7-
Topics: Animals; Bacteria; Citric Acid Cycle; Fatty Acids, Volatile; Feces; Female; Gastrointestinal Microbiome; Hesperidin; Homeostasis; Humans; Magnetic Resonance Spectroscopy; Male; Metabolome; Mice; Mice, Inbred C57BL | 2021 |
Investigating hesperetin nanocrystals with tailor-made sizes for the prevention and treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Hesperidin; Humans; Nanoparticles; Solubility | 2021 |
Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice.
Topics: Animals; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Design; Hesperidin; Inflammation; Liver; Mice; Mice, Inbred C57BL; Molecular Structure; Nitric Oxide; RAW 264.7 Cells; Reactive Oxygen Species; Structure-Activity Relationship; Triazoles | 2021 |
Cinnamaldehyde and hesperetin attenuate TNBS-induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway.
Topics: Acrolein; Animals; Colitis, Ulcerative; Hesperidin; Janus Kinase 2; Male; Rats; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Trinitrobenzenesulfonic Acid | 2021 |
Nanoemulsion for Improving the Oral Bioavailability of Hesperetin: Formulation Optimization and Absorption Mechanism.
Topics: Administration, Oral; Animals; Biological Availability; Emulsions; Hesperidin; Intestinal Absorption; Rats; Rats, Sprague-Dawley | 2021 |
In vitro study of Hesperetin and Hesperidin as inhibitors of zika and chikungunya virus proteases.
Topics: Animals; Chikungunya virus; Chlorocebus aethiops; Citrus; Hesperidin; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Docking Simulation; Peptide Hydrolases; Plant Extracts; Protein Conformation; Vero Cells; Viral Proteins; Zika Virus | 2021 |
Inhibition of histone acetyltransferase by naringenin and hesperetin suppresses Txnip expression and protects pancreatic β cells in diabetic mice.
Topics: Acetylation; Animals; Carrier Proteins; Citrus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Flavanones; Hesperidin; Histone Acetyltransferases; Histones; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Rats; Thioredoxins | 2021 |
Hesperetin promotes DOT1L degradation and reduces histone H3K79 methylation to inhibit gastric cancer metastasis.
Topics: Animals; Hesperidin; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Mice, Nude; Stomach Neoplasms | 2021 |
Evaluation of hesperetin-loaded on multiple wall carbon nanotubes on cerebral ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Drug Evaluation, Preclinical; Hesperidin; Male; Nanotubes, Carbon; Rats; Rats, Wistar; Reperfusion Injury; Spectroscopy, Fourier Transform Infrared | 2021 |
Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Availability; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Diterpenes, Kaurane; Drug Carriers; Drug Compounding; Drug Liberation; Female; Hesperidin; Humans; Membrane Potential, Mitochondrial; Mice; Micelles; Nanoparticles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Solubility; Tissue Distribution; Tumor Burden | 2021 |
Targeting FGL2, a molecular drug target for glioblastoma, with natural compounds through virtual screening method.
Topics: Antineoplastic Agents; Apoptosis; Betacyanins; Cell Proliferation; Computer Simulation; Diterpenes; Drug Screening Assays, Antitumor; Fibrinogen; Gene Expression Regulation; Glioblastoma; Hesperidin; Humans; Molecular Targeted Therapy; Protein Binding | 2021 |
Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Dose-Response Relationship, Drug; Electrocardiography; Heart Function Tests; Hesperidin; Inflammation; Male; Mice; Myocardial Ischemia; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Sirtuin 1; Vasodilator Agents; Verapamil | 2021 |
Hindering the Synchronization Between miR-486-5p and H19 lncRNA by Hesperetin Halts Breast Cancer Aggressiveness Through Tuning ICAM-1.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Hesperidin; Humans; Intercellular Adhesion Molecule-1; MicroRNAs; Middle Aged; RNA, Long Noncoding; Tumor Cells, Cultured | 2022 |
Discovery of 7-O-1, 2, 3-triazole hesperetin derivatives as multi-target-directed ligands against Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Drug Discovery; Hesperidin; Ligands; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Neuroprotective Agents; Nitric Oxide; Protein Binding; Rats; Transcription Factor RelA; Triazoles | 2021 |
Hesperetin as an inhibitor of the snake venom serine protease from Bothrops jararaca.
Topics: Animals; Bothrops; Brazil; Chromatography, Liquid; Crotalid Venoms; Hesperidin; Serine Proteases; Tandem Mass Spectrometry | 2021 |
Investigation of potential inhibitor properties of ethanolic propolis extracts against ACE-II receptors for COVID-19 treatment by molecular docking study.
Topics: Angiotensin-Converting Enzyme 2; Animals; Bees; Caffeic Acids; COVID-19 Drug Treatment; Flavanones; Flavonoids; Hesperidin; Humans; Luteolin; Molecular Docking Simulation; Phenylethyl Alcohol; Plant Extracts; Propolis; Quercetin; Rutin | 2021 |
Hesperetin ameliorates hepatic oxidative stress and inflammation
Topics: Animals; Antioxidant Response Elements; Diet, High-Fat; Hep G2 Cells; Hepatocytes; Hesperidin; Humans; Interleukin-6; Lipid Metabolism; Liver; Liver Cirrhosis; Male; NF-E2-Related Factor 2; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction; Transcription Factor RelA; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2021 |
Hesperetin regulates transforming growth factor-β1/Smads pathway to suppress epithelial-mesenchymal transition -mediated invasion and migration in cervical cancer cell.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; HeLa Cells; Hesperidin; Humans; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Uterine Cervical Neoplasms | 2021 |
Hesperetin rescues emotional memory and synaptic plasticity deficit in aged rats.
Topics: Animals; Hesperidin; Hippocampus; Long-Term Potentiation; Neuronal Plasticity; Rats | 2021 |
Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRα signal in an AMPK-dependent manner.
Topics: AMP-Activated Protein Kinase Kinases; Atherosclerosis; Cholesterol; Foam Cells; Hesperidin; Humans; Liver X Receptors; Protein Kinases; THP-1 Cells | 2021 |
Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Electroconvulsive Therapy; Hesperidin; Hippocampus; Male; Maze Learning; Memory Disorders; Oxidative Stress; Rats; Rats, Wistar; Reserpine | 2021 |
Hesperetin ameliorates diabetes-associated anxiety and depression-like behaviors in rats via activating Nrf2/ARE pathway.
Topics: Animals; Anxiety; Depression; Diabetes Mellitus, Experimental; Glycogen Synthase Kinase 3 beta; Hesperidin; NF-E2-Related Factor 2; Oxidative Stress; Rats | 2021 |
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection.
Topics: Angiotensin-Converting Enzyme 2; Animals; Cell Line, Tumor; Chlorocebus aethiops; Coronavirus Papain-Like Proteases; COVID-19; COVID-19 Drug Treatment; Hesperidin; Humans; Molecular Docking Simulation; SARS-CoV-2; Serine Endopeptidases; Spike Glycoprotein, Coronavirus; Vero Cells | 2021 |
Microbial Phosphorylation Product of Hesperetin by
Topics: Animals; Bacillus subtilis; Biological Availability; Caco-2 Cells; Hesperidin; Humans; Phosphorylation; Rats | 2021 |
Screening and heterologous expression of flavone synthase and flavonol synthase to catalyze hesperetin to diosmetin.
Topics: Angelica archangelica; Camellia; Flavonoids; Hesperidin; Mixed Function Oxygenases; Oxidoreductases; Plant Proteins; Synthetic Biology | 2021 |
Potential of Vasoprotectives to Inhibit Non-Enzymatic Protein Glycation, and Reactive Carbonyl and Oxygen Species Uptake.
Topics: Animals; Antioxidants; Chromatography, High Pressure Liquid; Glycation End Products, Advanced; Hesperidin; Humans; Hydrogen-Ion Concentration; Pyruvaldehyde; Spectrometry, Mass, Electrospray Ionization | 2021 |
Hesperetin Inhibits Expression of Virulence Factors and Growth of
Topics: Bacterial Proteins; Blotting, Western; Flavanones; Helicobacter Infections; Helicobacter pylori; Hesperidin; Stomach Neoplasms; Virulence Factors | 2021 |
Polyphenols from Citrus Tacle
Topics: Citrus; Dietary Supplements; Enzyme Inhibitors; Flavanones; Flavonoids; Fruit; Hesperidin; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Models, Molecular; Molecular Docking Simulation; Plant Extracts; Polyphenols; Protein Binding; Protein Conformation | 2021 |
Hesperetin may alleviate the development of doxorubicin-induced pulmonary toxicity by decreasing oxidative stress and apoptosis in male rats.
Topics: Animals; Apoptosis; Body Weight; Caspase 3; Cytochromes c; Doxorubicin; Hesperidin; Lung; Male; Organ Size; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats, Sprague-Dawley; RNA, Messenger | 2021 |
Hesperetin inhibits KSHV reactivation and is reversed by HIF1α overexpression.
Topics: Antiviral Agents; Apoptosis; Gene Expression Regulation, Viral; Herpesviridae Infections; Herpesvirus 8, Human; Hesperidin; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Viral Proteins; Virus Activation; Virus Replication | 2021 |
Pathological analysis of hesperetin-derived small cell lung cancer by artificial intelligence technology under fiberoptic bronchoscopy.
Topics: Artificial Intelligence; Bronchoscopy; Fiber Optic Technology; Hesperidin; Humans; Lung Neoplasms; Small Cell Lung Carcinoma; Technology | 2021 |
Green synthesis of kudzu vine biochar decorated graphene-like MoSe
Topics: Charcoal; Graphite; Hesperidin; Oxidoreductases; Pueraria | 2022 |
The potential therapeutic effects of Trifolium alexandrinum extract, hesperetin and quercetin against diabetic nephropathy via attenuation of oxidative stress, inflammation, GSK-3β and apoptosis in male rats.
Topics: Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycogen Synthase Kinase 3 beta; Hesperidin; Hypoglycemic Agents; Inflammation; Kidney; Male; Oxidative Stress; Phytotherapy; Plant Extracts; Quercetin; Rats; Rats, Wistar; Trifolium | 2022 |
The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1).
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Autophagy-Related Protein 5; Beclin-1; Doxorubicin; Dynamins; Gene Expression; Hesperidin; Male; MicroRNAs; Oxidative Stress; Rats; Rats, Sprague-Dawley; Testicular Diseases; Testis; TOR Serine-Threonine Kinases | 2022 |
Neuroprotective Effects of Hesperetin in Regulating Microglia Polarization after Ischemic Stroke by Inhibiting TLR4/NF-
Topics: Animals; Cytokines; Hesperidin; Interleukin-10; Ischemic Stroke; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; NF-kappa B; RNA, Messenger; Toll-Like Receptor 4; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2021 |
O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholesterol; Cytokines; Hesperidin; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; RAW 264.7 Cells; Signal Transduction; Transcription Factor RelA; Transcription Factors; Triglycerides | 2022 |
Hesperetin Inhibits Sphingosylphosphorylcholine-Induced Vascular Smooth Muscle Contraction by Regulating the Fyn/Rho-Kinase Pathway.
Topics: Animals; Calcium; Hesperidin; Muscle Contraction; Muscle, Smooth, Vascular; Phosphorylation; Phosphorylcholine; rho-Associated Kinases; Sphingosine; Swine | 2022 |
From the Physicochemical Characteristic of Novel Hesperetin Hydrazone to Its In Vitro Antimicrobial Aspects.
Topics: Anti-Bacterial Agents; Coordination Complexes; Copper; Gram-Negative Bacteria; Gram-Positive Bacteria; Hesperidin; Hydrazones; Microbial Sensitivity Tests | 2022 |
Antioxidant and Antitumor Activities of Newly Synthesized Hesperetin Derivatives.
Topics: Antineoplastic Agents; Antioxidants; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; Hesperidin; Humans; MCF-7 Cells; Neoplasms | 2022 |
Production of hesperetin from naringenin in an engineered Escherichia coli consortium.
Topics: Escherichia coli; Flavanones; Hesperidin | 2022 |
The Citrus Flavonoid Hesperetin Encounters Diabetes-Mediated Alzheimer-Type Neuropathologic Changes through Relieving Advanced Glycation End-Products Inducing Endoplasmic Reticulum Stress.
Topics: Alzheimer Disease; Apoptosis; Citrus; Diabetes Mellitus; Endoplasmic Reticulum Stress; Flavonoids; Glycation End Products, Advanced; Hesperidin; Humans | 2022 |
Hesperetin protects against diesel exhaust particles-induced cardiovascular oxidative stress and inflammation in Wistar rats.
Topics: Animals; Cardiovascular System; Hesperidin; Inflammation; Lipids; Male; Oxidative Stress; Particulate Matter; Rats; Rats, Wistar; Vehicle Emissions | 2022 |
Hesperetin (citrus peel flavonoid aglycone) encapsulation using pea protein-high methoxyl pectin electrostatic complexes: complex optimization and biological activity.
Topics: Citrus; Citrus sinensis; Flavonoids; Hesperidin; Pea Proteins; Pectins; Polyphenols; Static Electricity; Water | 2022 |
Antidiabetic efficacy of Trifolium alexandrinum extracts hesperetin and quercetin in ameliorating carbohydrate metabolism and activating IR and AMPK signaling in the pancreatic tissues of diabetic rats.
Topics: AMP-Activated Protein Kinases; Animals; Antioxidants; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Transport Proteins, Facilitative; Hesperidin; Hypoglycemic Agents; Insulin; Liver; Phosphatidylinositol 3-Kinases; Plant Extracts; Quercetin; Rats; Rats, Wistar; Receptor, Insulin; Streptozocin; Trifolium | 2022 |
Amorphous Inclusion Complexes: Molecular Interactions of Hesperidin and Hesperetin with HP-Β-CD and Their Biological Effects.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Biological Availability; Calorimetry, Differential Scanning; Hesperidin; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2022 |
Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2?
Topics: COVID-19 Drug Treatment; Hesperidin; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; SARS-CoV-2 | 2022 |
Hesperetin alleviates DMH induced toxicity via suppressing oxidative stress and inflammation in the colon of Wistar rats.
Topics: 1,2-Dimethylhydrazine; Animals; Antioxidants; Catalase; Colon; Colonic Neoplasms; Glutathione; Hesperidin; Inflammation; Mucins; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2022 |
Hesperetin derivative decreases CCl
Topics: Animals; Cell Line; Hedgehog Proteins; Hesperidin; Liver; Liver Cirrhosis; Mice; Patched-1 Receptor; Transforming Growth Factor beta1 | 2022 |
Hesperetin-Based Hydrogels Protect the Skin against UV Radiation-Induced Damage.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Hesperidin; Hydrogels; Oxidative Stress; Peroxidase; Rats; Skin; Superoxide Dismutase; Ultraviolet Rays | 2022 |
Targeting colon cancer stem cells using novel doublecortin like kinase 1 antibody functionalized folic acid conjugated hesperetin encapsulated chitosan nanoparticles.
Topics: Cell Line, Tumor; Cell Proliferation; Chitosan; Colonic Neoplasms; Doublecortin-Like Kinases; Folic Acid; Hesperidin; Humans; Intracellular Signaling Peptides and Proteins; Nanoparticles; Neoplastic Stem Cells; Protein Serine-Threonine Kinases | 2022 |
Hesperetin activated SIRT1 neutralizes cadmium effects on the early bovine embryo development.
Topics: Animals; Cadmium; Cattle; Embryonic Development; Female; Hesperidin; Molecular Docking Simulation; Nuclear Respiratory Factors; Sirtuin 1 | 2022 |
7-O-(2- (Propylamino)-2-oxoethyl) hesperetin attenuates inflammation and protects against alcoholic liver injury by NLRP12.
Topics: Animals; Anti-Inflammatory Agents; Ethanol; Hesperidin; Inflammation; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Liver; Liver Diseases, Alcoholic; Mice; Mice, Inbred C57BL; NF-kappa B; RAW 264.7 Cells | 2022 |
Hesperetin attenuates UVA-induced photodamage in human dermal fibroblast cells.
Topics: Cells, Cultured; Fibroblasts; Hesperidin; Humans; Skin; Skin Aging; Ultraviolet Rays | 2022 |
Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice.
Topics: Aging; Animals; Autophagy-Related Proteins; Hesperidin; Humans; Longevity; Mice; Mice, Knockout; Nerve Tissue Proteins | 2022 |
Topics: Accidents, Occupational; Adult; Animals; Anxiety; beta Catenin; Chromatography, High Pressure Liquid; Chronic Disease; Cities; Depression; Drugs, Chinese Herbal; Flavonoids; Heat Stroke; Hesperidin; Humans; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-10; Interleukin-6; Kruppel-Like Factor 4; Macrophages, Alveolar; Medical Staff; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Occupational Health; Occupational Injuries; Occupational Stress; Occupations; PPAR gamma; Pulmonary Fibrosis; RNA, Messenger; Sanitation; Silicon Dioxide; Sinusitis; Stress, Psychological; Surveys and Questionnaires; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; X-Box Binding Protein 1; Young Adult | 2022 |
Hesperetin mitigates sorafenib-induced cardiotoxicity in mice through inhibition of the TLR4/NLRP3 signaling pathway.
Topics: Animals; Cardiotoxicity; Hesperidin; Interleukin-6; Male; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Sorafenib; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2022 |
Cationic Okra gum coated nanoliposomes as a pH-sensitive carrier for co-delivery of hesperetin and oxaliplatin in colorectal cancers.
Topics: Abelmoschus; Catalase; Cations; Cell Line, Tumor; Colonic Neoplasms; Excipients; Hesperidin; Hydrogen-Ion Concentration; Liposomes; Oxaliplatin | 2022 |
Nanophytosomes of hesperidin and of hesperetin: Preparation, characterization, and in vivo evaluation.
Topics: Hesperidin; Phospholipids; X-Ray Diffraction | 2023 |
Hesperetin from Root Extract of
Topics: A549 Cells; Anti-Inflammatory Agents; Antipyretics; Caspase 1; Clerodendrum; COVID-19 Drug Treatment; Cytokines; Flavonoids; Hesperidin; Humans; Inflammasomes; Interleukin-18; Interleukin-6; Lung; NLR Family, Pyrin Domain-Containing 3 Protein; Petasites; Plant Extracts; Proto-Oncogene Proteins c-akt; SARS-CoV-2; Solvents; Spike Glycoprotein, Coronavirus; Transcription Factor AP-1 | 2022 |
Hesperetin induces apoptosis in A549 cells via the Hsp70‑mediated activation of Bax.
Topics: A549 Cells; Apoptosis; bcl-2-Associated X Protein; Flavonoids; Hesperidin; HSP70 Heat-Shock Proteins; Humans; Ligases; Proteasome Endopeptidase Complex | 2022 |
Multiomics Analyses Reveal That Long-Term Intake of Hesperetin-7-
Topics: Animals; Bacteria; Bile Acids and Salts; Gastrointestinal Microbiome; Glucosides; Hesperidin; Liver; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S | 2022 |
Bioactivity-boosting strategy based on combination of anti-allergic O-methylated catechin with a Citrus flavanone, hesperetin.
Topics: Animals; Anti-Allergic Agents; Catechin; Flavanones; Hesperidin; Immunoglobulin E; Mice; Passive Cutaneous Anaphylaxis; Rats | 2023 |
Synthesis, characterization, and evaluation of Hesperetin nanocrystals for regenerative dentistry.
Topics: Cell Differentiation; Cells, Cultured; Dental Pulp; Dentistry; Hesperidin; Humans; Osteogenesis; Stem Cells | 2023 |
Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents.
Topics: Collagenases; Hesperidin; Humans; Hyaluronoglucosaminidase; Pancreatic Elastase; Rhamnose; Skin Aging | 2023 |
Preparation and physicochemical properties characterization of hesperetin-grafted pectin conjugate.
Topics: Hesperidin; Pectins; X-Ray Diffraction | 2023 |
Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Hesperidin; Humans; Molecular Docking Simulation; Reactive Oxygen Species; Superoxide Dismutase | 2023 |
Citrus Flavonoid Hesperetin Inhibits α-Synuclein Fibrillogenesis, Disrupts Mature Fibrils, and Reduces Their Cytotoxicity: In Vitro and In Vivo Studies.
Topics: alpha-Synuclein; Amyloid; Flavonoids; Hesperidin; Humans; Parkinson Disease | 2023 |