hesperetin and diosmetin

hesperetin has been researched along with diosmetin in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.26)18.2507
2000's6 (31.58)29.6817
2010's10 (52.63)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Barbhuiya, TK; Jayaprakash, V; Mohd Siddique, MU; Sinha, BN1
Augereau, JM; Billon, M; Gleye, J; Herbert, JM; Lale, A; Leconte, M1
Asada, S; Imai, Y; Sugimoto, Y; Tsukahara, S1
Bronze, MR; Mendes, T; Serra, H; Simplício, AL1
Chou, CJ; Frei, N; Grigorov, M; Lo Piparo, E; Scheib, H; Williamson, G1
Gavande, N; Hanrahan, JR; Hibbs, DE; Kim, MS; Matin, A; Roubin, RH; Salam, NK; Yang, NX1
Itoh, T; Sakakibara, H; Shimoi, K; Takemura, H; Yamamoto, K1
Goettert, M; Koch, P; Laufer, S; Merfort, I; Schattel, V1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Doddareddy, MR; Gavande, N; Groundwater, PW; Hibbs, DE; Matin, A; Nammi, S; Roubin, RH1
Bicknell, KA; Farrimond, JA; Putnam, SE; Swioklo, S; Watson, KA; Williamson, EM1
Han, C; Kong, L; Lei, J; Li, S; Liu, C; Peng, W; Wang, Z; Xu, X1
Cho, YB; Han, JS; Hwang, BY; Kim, JG; Kwon, H; Le, TPL; Lee, D; Lee, JW; Lee, MK1
Liu, F; Peng, Y; Ye, J; Yuan, J1
Kasmas, S; Niopas, I; Spanakis, M1
Bortolozzo, S; Floreani, M; Moro, S; Nassi, A; Palatini, P; Pavanetto, M; Quintieri, L; Stragliotto, S1
Floreani, M; Moro, S; Palatini, P; Quintieri, L1
Cerdà, V; Clavijo, S; Portugal, L; Sammani, MS; Seddik, H; Suárez, R1
Ding, S; Huang, X; Liu, J; Shan, Y; Tian, M; Wang, Z; Xiao, F1

Reviews

1 review(s) available for hesperetin and diosmetin

ArticleYear
Phytoestrogens and their synthetic analogues as substrate mimic inhibitors of CYP1B1.
    European journal of medicinal chemistry, 2019, Feb-01, Volume: 163

    Topics: Animals; Antineoplastic Agents, Phytogenic; Classification; Cluster Analysis; Cytochrome P-450 CYP1B1; Enzyme Inhibitors; Humans; Molecular Mimicry; Neoplasms; Phytoestrogens

2019

Other Studies

18 other study(ies) available for hesperetin and diosmetin

ArticleYear
Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes.
    Journal of natural products, 1996, Volume: 59, Issue:3

    Topics: Amino Acid Sequence; Blood Coagulation; Cell Adhesion; Endotoxins; Flavonoids; Humans; In Vitro Techniques; Interleukin-1; Molecular Sequence Data; Monocytes

1996
Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.
    Cancer research, 2004, Jun-15, Volume: 64, Issue:12

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; Genistein; Humans; K562 Cells; Neoplasm Proteins; Topotecan; Transduction, Genetic; Tritium

2004
Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones.
    Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7

    Topics: Caco-2 Cells; Electrophoresis, Capillary; Flavanones; Flavones; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Molecular Structure; Molecular Weight

2008
Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase.
    Journal of medicinal chemistry, 2008, Jun-26, Volume: 51, Issue:12

    Topics: alpha-Amylases; Catalytic Domain; Digestion; Flavones; Flavonols; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Protein Conformation; Saliva; Starch; Structure-Activity Relationship

2008
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
    Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21

    Topics: Benzopyrans; Cell Line; Humans; PPAR alpha; PPAR gamma; Structure-Activity Relationship

2009
Selective inhibition of methoxyflavonoids on human CYP1B1 activity.
    Bioorganic & medicinal chemistry, 2010, Sep-01, Volume: 18, Issue:17

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Flavonoids; Humans; Models, Molecular; Structure-Activity Relationship

2010
Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.
    Chembiochem : a European journal of chemical biology, 2010, Dec-10, Volume: 11, Issue:18

    Topics: Animals; Flavonoids; Humans; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinase 14; Models, Molecular; Protein Kinase Inhibitors; Structure-Activity Relationship

2010
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.
    Bioorganic & medicinal chemistry, 2013, Feb-01, Volume: 21, Issue:3

    Topics: Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Isoflavones; Models, Molecular; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Structure-Activity Relationship

2013
Defining Key Structural Determinants for the Pro-osteogenic Activity of Flavonoids.
    Journal of natural products, 2015, Nov-25, Volume: 78, Issue:11

    Topics: Cell Differentiation; Flavonoids; Humans; Mesenchymal Stem Cells; Molecular Structure; Osteogenesis; Signal Transduction; Structure-Activity Relationship

2015
Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro.
    Bioorganic & medicinal chemistry, 2019, 01-15, Volume: 27, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Flavones; Histone Demethylases; Humans; Membrane Potential, Mitochondrial; Mitochondria; Molecular Structure; Structure-Activity Relationship

2019
Sesquiterpenoids from
    Journal of natural products, 2021, 03-26, Volume: 84, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Chrysanthemum; Flavones; Flowers; Glucosides; Lactones; Mice; Molecular Structure; Nitric Oxide; Phytochemicals; Plants, Medicinal; RAW 264.7 Cells; Republic of Korea; Sesquiterpenes

2021
Determination of active components in rosemary by capillary electrophoresis with electrochemical detection.
    Journal of pharmaceutical and biomedical analysis, 2005, Sep-15, Volume: 39, Issue:3-4

    Topics: Antioxidants; Apigenin; Buffers; Caffeic Acids; Chromatography, High Pressure Liquid; Cinnamates; Coumaric Acids; Depsides; Electrochemistry; Electrodes; Electrophoresis, Capillary; Flavonoids; Hesperidin; Hydrogen-Ion Concentration; Ions; Luteolin; Models, Chemical; Plant Extracts; Regression Analysis; Rosmarinic Acid; Rosmarinus; Temperature; Time Factors

2005
Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin.
    Biomedical chromatography : BMC, 2009, Volume: 23, Issue:2

    Topics: Diosmin; Drug Stability; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Hesperidin; Humans; Linear Models; Male; Oxidation-Reduction; Reference Standards; Reproducibility of Results; Sensitivity and Specificity

2009
Flavonoids diosmetin and hesperetin are potent inhibitors of cytochrome P450 2C9-mediated drug metabolism in vitro.
    Drug metabolism and pharmacokinetics, 2010, Volume: 25, Issue:5

    Topics: Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Biocatalysis; Cytochrome P-450 CYP2C9; Diclofenac; Female; Flavonoids; Flurbiprofen; Hesperidin; Humans; Hydroxylation; Male; Microsomes, Liver; Models, Molecular; NADP; Pharmaceutical Preparations; Recombinant Proteins; Thermodynamics

2010
Inhibition of cytochrome P450 2C8-mediated drug metabolism by the flavonoid diosmetin.
    Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:6

    Topics: Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2C8; Flavonoids; Hesperidin; Humans; Inactivation, Metabolic; Microsomes, Liver; Molecular Dynamics Simulation; Paclitaxel

2011
Use of multiresponse statistical techniques to optimize the separation of diosmin, hesperidin, diosmetin and hesperitin in different pharmaceutical preparations by high performance liquid chromatography with UV-DAD.
    Talanta, 2017, May-15, Volume: 167

    Topics: Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Diosmin; Flavonoids; Hesperidin; Pharmaceutical Preparations; Solid Phase Microextraction; Ultraviolet Rays

2017
Screening and heterologous expression of flavone synthase and flavonol synthase to catalyze hesperetin to diosmetin.
    Biotechnology letters, 2021, Volume: 43, Issue:11

    Topics: Angelica archangelica; Camellia; Flavonoids; Hesperidin; Mixed Function Oxygenases; Oxidoreductases; Plant Proteins; Synthetic Biology

2021