hes1-protein--human has been researched along with shogaol* in 1 studies
1 other study(ies) available for hes1-protein--human and shogaol
| Article | Year |
|---|---|
6-Shogaol suppresses the growth of breast cancer cells by inducing apoptosis and suppressing autophagy via targeting notch signaling pathway.
Breast cancer is one of the most commonly diagnosed cancer among women globally. Shogaol, the active constituent of many spices belonging to the Zingiberaceae family, has received wide attention among other shogaols in terms of its anticancer activity against different neoplasms. To date, its efficacy at the detailed molecular level against breast cancer has not been established.. In the current study, we investigated the cytotoxic potential and the underlying molecular details of 6-shogaol against breast adenocarcinomacells (MCF-7), and breast ductal carcinoma cells (T47D). Cytotoxicity assay, cell cycle analysis. Real-time PCR (qPCR), apoptosis and autophagy techniques were used for the determination and molecular investigation of its anticancer properties.. 6-Shogaol is a promising candidate to be considered as a treatment of breast cancer. Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Breast Neoplasms; Catechols; Cell Proliferation; Cisplatin; Cyclin D1; Dose-Response Relationship, Drug; Female; G2 Phase Cell Cycle Checkpoints; Humans; MCF-7 Cells; Oxaliplatin; Receptors, Notch; Signal Transduction; Transcription Factor HES-1 | 2020 |