heroin and tri-o-cresyl-phosphate

heroin has been researched along with tri-o-cresyl-phosphate* in 1 studies

Other Studies

1 other study(ies) available for heroin and tri-o-cresyl-phosphate

Article	Year
Alteration of in vivo and in vitro effects of heroin by esterase inhibition. Toxicology and applied pharmacology, 1986, Volume: 82, Issue:1 Selective inhibition of peripheral esterases by tri-ortho-tolyl phosphate in the mouse resulted in an increase in the analgetic activity of heroin, without affecting the activity of morphine. In vitro inhibition of esterases by paraoxon reduced the affinity of heroin for the opiate receptor, while that of morphine was unaffected. These results suggest that both central and peripheral esterases are involved in the metabolism of heroin and that interference with critical esterases can alter its pharmacologic and toxicologic effects. Topics: Acetates; Acetic Acid; Analgesia; Animals; Drug Interactions; Esterases; Heroin; Male; Mice; Morphine; Morphine Derivatives; Paraoxon; Rats; Receptors, Opioid; Tritolyl Phosphates	1986

Article

Year

Alteration of in vivo and in vitro effects of heroin by esterase inhibition.

Toxicology and applied pharmacology, 1986, Volume: 82, Issue:1

Selective inhibition of peripheral esterases by tri-ortho-tolyl phosphate in the mouse resulted in an increase in the analgetic activity of heroin, without affecting the activity of morphine. In vitro inhibition of esterases by paraoxon reduced the affinity of heroin for the opiate receptor, while that of morphine was unaffected. These results suggest that both central and peripheral esterases are involved in the metabolism of heroin and that interference with critical esterases can alter its pharmacologic and toxicologic effects.

Topics: Acetates; Acetic Acid; Analgesia; Animals; Drug Interactions; Esterases; Heroin; Male; Mice; Morphine; Morphine Derivatives; Paraoxon; Rats; Receptors, Opioid; Tritolyl Phosphates

1986