herbimycin and quinone

herbimycin has been researched along with quinone* in 2 studies

Other Studies

2 other study(ies) available for herbimycin and quinone

Article	Year
Total synthesis of herbimycin A. Organic letters, 2014, Jun-20, Volume: 16, Issue:12 Benzoquinone ansamycin antibiotic herbimycin A was synthesized in 19 linear steps and 4.2% yield. Highlighted is the design of a chiral γ-lactone as the C11-C15 synthon that enabled a facile catalytic asymmetric synthesis of the challenging C8-C20 fragment of the target molecule. The easy access to the stereogenic centers and high overall yield made the strategy applicable in the molecular editing of benzoquinone ansamycins. Topics: Anti-Bacterial Agents; Benzoquinones; Catalysis; Lactams, Macrocyclic; Lactones; Molecular Structure; Rifabutin; Stereoisomerism	2014
Studies on the syntheses of benzoquinone ansamycin antibiotics. Syntheses of the C5-C15 subunits of macbecin I, geldanamycin, and herbimycin A. Organic letters, 2006, May-25, Volume: 8, Issue:11 [reaction: see text] A general and convergent route to the C(5)-C(15) subunits of the benzoquinone ansamycin antibiotics macbecin I, geldanamycin, and herbimycin A is described. Each subunit is prepared by the stepwise coupling of differentially functionalized aldehydes with a pentenyl dianion equivalent derived from diastereoselective pentynylation and regioselective reductive coupling. Topics: Anti-Bacterial Agents; Benzoquinones; Lactams, Macrocyclic; Molecular Structure; Rifabutin; Stereoisomerism	2006

Article

Year

Organic letters, 2014, Jun-20, Volume: 16, Issue:12

Benzoquinone ansamycin antibiotic herbimycin A was synthesized in 19 linear steps and 4.2% yield. Highlighted is the design of a chiral γ-lactone as the C11-C15 synthon that enabled a facile catalytic asymmetric synthesis of the challenging C8-C20 fragment of the target molecule. The easy access to the stereogenic centers and high overall yield made the strategy applicable in the molecular editing of benzoquinone ansamycins.

Topics: Anti-Bacterial Agents; Benzoquinones; Catalysis; Lactams, Macrocyclic; Lactones; Molecular Structure; Rifabutin; Stereoisomerism

2014

Studies on the syntheses of benzoquinone ansamycin antibiotics. Syntheses of the C5-C15 subunits of macbecin I, geldanamycin, and herbimycin A.

Organic letters, 2006, May-25, Volume: 8, Issue:11

[reaction: see text] A general and convergent route to the C(5)-C(15) subunits of the benzoquinone ansamycin antibiotics macbecin I, geldanamycin, and herbimycin A is described. Each subunit is prepared by the stepwise coupling of differentially functionalized aldehydes with a pentenyl dianion equivalent derived from diastereoselective pentynylation and regioselective reductive coupling.

Topics: Anti-Bacterial Agents; Benzoquinones; Lactams, Macrocyclic; Molecular Structure; Rifabutin; Stereoisomerism

2006