heraclenin and imperatorin

heraclenin has been researched along with imperatorin* in 2 studies

Other Studies

2 other study(ies) available for heraclenin and imperatorin

Article	Year
Simultaneous determination of imperatorin and its metabolites in vitro and in vivo by a GC-MS method: application to a bioavailability and protein binding ability study in rat plasma. Biomedical chromatography : BMC, 2014, Volume: 28, Issue:7 In this study, a simple and sensitive gas chromatography-mass spectrometry method was developed for the study of bioavailability and protein binding and the metabolism of imperatorin in rat. The results showed that the pharmacokinetics of imperatorin after intravenous and oral administration in rats exhibited linear characteristics. The absolute bioavailability of imperatorin was calculated as ~3.85, ~33.51 and ~34.76% for 6.25, 12.5 and 25 mg/kg, respectively. The low bioavailability of imperatorin may be attributed to the poor absorption or extensive metabolism. The phase I metabolites of imperatorin formed in vitro by rat liver microsomes were studied, and two metabolites were isolated and identified as xanthotoxol and heraclenin. Following oral administration of imperatorin, one metabolite (heraclenin) was detected in rat plasma, and two potential metabolites (xanthotoxol and heraclenin) were detected in rat urine. However, none of potential metabolites was detected in rat feces and bile. The results showed that the metabolites of imperatorin were excreted by kidney, and heraclenin was associated with an active component. Demethylation and oxygenization were the main metabolic pathways. In vitro plasma protein binding of imperatorin was 90.1 and 92.6% for the spiked rat plasma concentrations of 1.0 and 50.0 µg/mL, respectively, indicating that imperatorin showed slow distribution into the intra- and extracellular space. Topics: Administration, Oral; Animals; Bile; Biological Availability; Blood Proteins; Feces; Furocoumarins; Gas Chromatography-Mass Spectrometry; Male; Microsomes, Liver; Protein Binding; Rats; Rats, Sprague-Dawley; Reproducibility of Results	2014
Coumarins from Angelica lucida L.--antibacterial activities. Molecules (Basel, Switzerland), 2009, Jul-27, Volume: 14, Issue:8 The first phytochemical investigation of the fruits of Angelica lucida has led to the isolation and characterization of five known coumarins (imperatorin, isoimperatorin, heraclenol, oxypeucedanin hydrate and heraclenin). All isolated compounds were identified by means of spectral and literature data. The extracts and the isolated constituents from A. lucida have been also evaluated for their antimicrobial activity against six Gram positive and negative bacteria, two oral pathogens and three human pathogenic fungi, exhibiting an interesting antimicrobial profile. Topics: Angelica; Anti-Infective Agents; Benzopyrans; Coumarins; Fruit; Fungi; Furans; Furocoumarins; Gram-Negative Bacteria; Gram-Positive Bacteria; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Plant Extracts	2009

Article

Year

Simultaneous determination of imperatorin and its metabolites in vitro and in vivo by a GC-MS method: application to a bioavailability and protein binding ability study in rat plasma.

Biomedical chromatography : BMC, 2014, Volume: 28, Issue:7

In this study, a simple and sensitive gas chromatography-mass spectrometry method was developed for the study of bioavailability and protein binding and the metabolism of imperatorin in rat. The results showed that the pharmacokinetics of imperatorin after intravenous and oral administration in rats exhibited linear characteristics. The absolute bioavailability of imperatorin was calculated as ~3.85, ~33.51 and ~34.76% for 6.25, 12.5 and 25 mg/kg, respectively. The low bioavailability of imperatorin may be attributed to the poor absorption or extensive metabolism. The phase I metabolites of imperatorin formed in vitro by rat liver microsomes were studied, and two metabolites were isolated and identified as xanthotoxol and heraclenin. Following oral administration of imperatorin, one metabolite (heraclenin) was detected in rat plasma, and two potential metabolites (xanthotoxol and heraclenin) were detected in rat urine. However, none of potential metabolites was detected in rat feces and bile. The results showed that the metabolites of imperatorin were excreted by kidney, and heraclenin was associated with an active component. Demethylation and oxygenization were the main metabolic pathways. In vitro plasma protein binding of imperatorin was 90.1 and 92.6% for the spiked rat plasma concentrations of 1.0 and 50.0 µg/mL, respectively, indicating that imperatorin showed slow distribution into the intra- and extracellular space.

Topics: Administration, Oral; Animals; Bile; Biological Availability; Blood Proteins; Feces; Furocoumarins; Gas Chromatography-Mass Spectrometry; Male; Microsomes, Liver; Protein Binding; Rats; Rats, Sprague-Dawley; Reproducibility of Results

2014

Coumarins from Angelica lucida L.--antibacterial activities.

Molecules (Basel, Switzerland), 2009, Jul-27, Volume: 14, Issue:8

The first phytochemical investigation of the fruits of Angelica lucida has led to the isolation and characterization of five known coumarins (imperatorin, isoimperatorin, heraclenol, oxypeucedanin hydrate and heraclenin). All isolated compounds were identified by means of spectral and literature data. The extracts and the isolated constituents from A. lucida have been also evaluated for their antimicrobial activity against six Gram positive and negative bacteria, two oral pathogens and three human pathogenic fungi, exhibiting an interesting antimicrobial profile.

Topics: Angelica; Anti-Infective Agents; Benzopyrans; Coumarins; Fruit; Fungi; Furans; Furocoumarins; Gram-Negative Bacteria; Gram-Positive Bacteria; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Plant Extracts

2009