heptelidic acid has been researched along with sesquiterpenes in 34 studies
| Studies (heptelidic acid) | Trials (heptelidic acid) | Recent Studies (post-2010) (heptelidic acid) | Studies (sesquiterpenes) | Trials (sesquiterpenes) | Recent Studies (post-2010) (sesquiterpenes) |
|---|---|---|---|---|---|
| 34 | 0 | 15 | 17,489 | 536 | 7,668 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (11.76) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 6 (17.65) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 8 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Endo, A; Kato, M; Sakai, K | 1 |
| Endo, A; Hasumi, K; Sakai, K | 3 |
| Endo, A; Hasumi, K; Kanbe, T; Sakai, K | 1 |
| Arai, M; Furuya, K; Haneishi, T; Itoh, Y; Kodama, K; Takahashi, S; Takiguchi, Y | 1 |
| Arai, M; Haneishi, T; Itoh, Y; Takahashi, S | 1 |
| Lapetina, EG; McDonald, B; Molina y Vedia, L; Reep, B | 1 |
| Endo, A; Fukushima, Y; Hasumi, K; Sakai, K; Watanabe, H | 1 |
| Nakazawa, M; Nomura, Y; Uehara, T | 1 |
| Enomoto, Y; Fang, F; Kamei, K; Masuma, R; Omura, S; Shiomi, K; Sugoh-Hagino, M; Tanaka, Y; Yamaguchi, Y; Zhang, CG; Zhang, XW | 1 |
| Fang, F; Omura, S; Tanaka, Y; Zhang, CH; Zhang, XW | 1 |
| Beisswenger, PJ; Howell, SK; Smith, K; Szwergold, BS | 1 |
| Endo, A; Ha, SH; Hasumi, K; Kim, JH; Lee, S; Lee, SD; Park, JB; Ryu, SH; Suh, PG | 1 |
| Gregus, Z; Németi, B | 1 |
| Miyamoto, Y; Saiwaki, T; Yasuda, Y; Yoneda, Y | 1 |
| Hasumi, K; Kumagai, S; Narasaki, R | 1 |
| Kim, JH; Lee, CH | 1 |
| Kuramochi, K; Kuriyama, I; Manita, D; Mizushina, Y; Sugawara, F; Takeuchi, T; Yamaguchi, Y; Yoshida, H | 1 |
| Chen, Y; Gong, F; Jiang, Y; Liao, H; Liu, J; Peng, X; Wang, M; Xiao, G; Yu, M; Zhang, S | 1 |
| Aussagues, Y; Bailly, C; Balakrishnan, A; Deshmukh, SK; Gomes, B; Jiotode, M; Kate, AS; Lavhale, RR; Long, C; Meignan, S; Molinier, N; Rahier, NJ; Ranadive, P; Robichon, C; Samson, A; Sautel, F; Tokdar, P; Verekar, SA | 1 |
| Doi, Y; Furuchi, T; Homma, H; Kaneko, Y; Kasuga, Y; Katane, M; Koyama, N; Kumakubo, S; Matsuda, S; Nakayama, K; Saitoh, Y; Sekine, M; Tanaka, T; Tomoda, H; Watanabe, M; Yoshida, N | 1 |
| Baccile, JA; Baldi, R; Chio, IIC; Dai, Z; Elemento, O; Gao, X; Johnson, MO; Liberti, MV; Liu, X; Locasale, JW; Madhukar, NS; McDonnell, DP; Mehrmohamadi, M; Rathmell, JC; Schroeder, FC; Shestov, AA; Wardell, SE | 1 |
| Koyama, Y; Nishimura, I; Oguma, T; Shinohara, Y | 1 |
| Koyama, Y; Nishimura, I; Shinohara, Y | 1 |
| Fu, XW; Han, C; Kong, LY; Liao, ST; Wang, JS; Xu, DQ | 1 |
| Allen, AE; Dai, Z; Guo, Z; Liberti, MV; Liu, JO; Locasale, JW; Ramesh, V; Singleton, KR; Wood, KC | 1 |
| Barbe, G; Chai, D; Chen, B; DeChristopher, B; Guay, D; Levesque, E; Mancuso, J | 1 |
| Gupta, GD; Kumar, V; Mukherjee, PK; Pachauri, S | 1 |
| Dixit, K; Horwitz, BA; Igumenova, TI; Kenerley, CM; Mukherjee, PK; Puckhaber, LS; Suh, C; Taylor, JT | 1 |
| Falahati, M; Sui, R; Wang, Z; Yuan, X; Zhang, L | 1 |
| Akutsu, H; Ando, K; Fujiya, M; Ichikawa, S; Isozaki, S; Kashima, S; Konishi, H; Moriichi, K; Ogawa, N; Ueno, N; Yamamoto, K; Yamamura, C | 1 |
| Gao, Z; Jing, C; Li, Y; Wang, R | 1 |
| Fujiya, M; Isozaki, S; Konishi, H; Moriichi, K; Ogawa, N; Tanaka, H; Yamamura, C | 1 |
34 other study(ies) available for heptelidic acid and sesquiterpenes
| Article | Year |
|---|---|
Koningic acid (heptelidic acid) inhibition of glyceraldehyde-3-phosphate dehydrogenases from various sources.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chickens; Erythrocytes; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Molecular Sequence Data; Muscles; Sesquiterpenes; Swine | 1992 |
Identification of koningic acid (heptelidic acid)-modified site in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase.
Topics: Amino Acids; Animals; Chromatography, High Pressure Liquid; Glyceraldehyde-3-Phosphate Dehydrogenases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Muscles; Rabbits; Sesquiterpenes | 1991 |
Two glyceraldehyde-3-phosphate dehydrogenase isozymes from the koningic acid (heptelidic acid) producer Trichoderma koningii.
Topics: Amino Acid Sequence; Dithionitrobenzoic Acid; Fermentation; Glyceraldehyde-3-Phosphate Dehydrogenases; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Structure; Molecular Weight; Sesquiterpenes; Trichoderma | 1990 |
Inactivation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase by koningic acid.
Topics: Animals; Enzyme Activation; Enzyme Reactivators; Glyceraldehyde-3-Phosphate Dehydrogenases; Muscles; Protein Binding; Rabbits; Sesquiterpenes; Substrate Specificity; Time Factors | 1988 |
Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid).
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Glyceraldehyde 3-Phosphate; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Lactates; Leucine; Liver; Mice; Neoplasms, Experimental; Rabbits; Rats; Sesquiterpenes; Thymidine; Trichoderma | 1985 |
A new sesquiterpene antibiotic, heptelidic acid producing organisms, fermentation, isolation and characterization.
Topics: Animals; Anti-Bacterial Agents; Ascomycota; Bacteria; Chaetomium; Chemical Phenomena; Chemistry; Chemistry, Physical; Drug Resistance, Microbial; Fermentation; Fungi; Mice; Mitosporic Fungi; Sesquiterpenes; Trichoderma | 1980 |
Structure of heptelidic acid, a new sesquiterpene antibiotic from fungi.
Topics: Anti-Bacterial Agents; Fungi; Molecular Conformation; Sesquiterpenes | 1980 |
Glyceraldehyde-3-phosphate dehydrogenase is required for the transport of nitric oxide in platelets.
Topics: Biological Transport; Blood Platelets; Cyclic GMP; Cytosol; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanylate Cyclase; Humans; In Vitro Techniques; Nitric Oxide; Platelet Aggregation; Sesquiterpenes | 1993 |
Cloning of two isozymes of Trichoderma koningii glyceraldehyde-3-phosphate dehydrogenase with different sensitivity to koningic acid.
Topics: Amino Acid Sequence; Animals; Aspergillus nidulans; Base Sequence; Binding Sites; Cloning, Molecular; DNA, Fungal; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Isoenzymes; Molecular Sequence Data; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Sesquiterpenes; Trichoderma | 1993 |
Koningic acid (a potent glyceraldehyde-3-phosphate dehydrogenase inhibitor)-induced fragmentation and condensation of DNA in NG108-15 cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cell Nucleus; DNA Fragmentation; DNA, Neoplasm; Glioma; Glyceraldehyde-3-Phosphate Dehydrogenases; Hybrid Cells; L-Lactate Dehydrogenase; Mice; Neuroblastoma; Nitric Oxide; Nitroprusside; Rats; Sesquiterpenes; Sulfhydryl Reagents | 1997 |
Antimalarial activity of radicicol, heptelidic acid and other fungal metabolites.
Topics: Animals; Antifungal Agents; Antimalarials; Fermentation; Humans; Lactones; Macrolides; Mice; Plasmodium berghei; Plasmodium falciparum; Sesquiterpenes; Structure-Activity Relationship | 1998 |
Heme-dependent radical generation from antimalarial fungal metabolites, radicicol and heptelidic acid.
Topics: Animals; Antimalarials; Artemisinins; Binding Sites; Free Radicals; Fungi; Heme; Hemin; Lactones; Macrolides; Mitosporic Fungi; Plasmodium falciparum; Sesquiterpenes | 1998 |
Glyceraldehyde-3-phosphate dehydrogenase activity as an independent modifier of methylglyoxal levels in diabetes.
Topics: Adult; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Erythrocytes; Female; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Oxidation-Reduction; Pyruvaldehyde; Sesquiterpenes | 2003 |
Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells.
Topics: Amino Acid Sequence; Animals; Benzamides; Catalytic Domain; Enzyme Activation; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Hydrogen Peroxide; Molecular Sequence Data; Oxidants; PC12 Cells; Pheochromocytoma; Phospholipase D; Precipitin Tests; Protein Binding; Rats; Sequence Analysis, Protein; Sesquiterpenes; Signal Transduction | 2003 |
The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase works as an arsenate reductase in human red blood cells and rat liver cytosol.
Topics: Animals; Arsenates; Cytosol; Enzyme Inhibitors; Erythrocytes; Glutathione; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Humans; In Vitro Techniques; Liver; NAD; Oxidation-Reduction; Phosphoglycerate Kinase; Rats; Rats, Wistar; Sesquiterpenes | 2005 |
Mechanism of the stress-induced collapse of the Ran distribution.
Topics: Active Transport, Cell Nucleus; Adenosine Triphosphate; Apyrase; beta Karyopherins; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; HeLa Cells; Humans; Hydrogen Peroxide; Oxidative Stress; ran GTP-Binding Protein; Sesquiterpenes; Transfection; Ultraviolet Rays; Wheat Germ Agglutinins | 2006 |
Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells.
Topics: Adenosine Triphosphate; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Glucose; Glycolysis; Humans; Mice; Neoplasms; Sesquiterpenes | 2008 |
Heptelidic acid, a sesquiterpene lactone, inhibits Etoposide-induced apoptosis in human leukemia U937 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase Inhibitors; DNA Fragmentation; Dose-Response Relationship, Drug; Etoposide; Humans; Neurodegenerative Diseases; Sesquiterpenes; Trichoderma; U937 Cells | 2009 |
Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases.
Topics: Acids; Cell Line, Tumor; DNA Nucleotidylexotransferase; DNA Polymerase beta; DNA-Directed DNA Polymerase; Female; Fungi; Genes, pol; HeLa Cells; Humans; Sesquiterpenes; Terpenes; Trichoderma | 2010 |
Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Autophagy; Autophagy-Related Protein 7; Deoxyglucose; Down-Regulation; Drug Resistance, Neoplasm; Female; Glycolysis; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Paclitaxel; RNA Interference; Sesquiterpenes; Signal Transduction; Ubiquitin-Activating Enzymes; Up-Regulation; Uterine Cervical Neoplasms | 2014 |
Anticancer activity of koningic acid and semisynthetic derivatives.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Fermentation; Glycolysis; Humans; Inhibitory Concentration 50; Lung Neoplasms; Mice; Mice, Nude; Sesquiterpenes; Structure-Activity Relationship; Trichoderma; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Identification and characterization of natural microbial products that alter the free d-aspartate content of mammalian cells.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Benzoquinones; HEK293 Cells; Humans; Lactams, Macrocyclic; PC12 Cells; Plicamycin; Rats; Sesquiterpenes; Stereoisomerism | 2016 |
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycolysis; Humans; Machine Learning; Metabolic Flux Analysis; Metabolomics; Mice, Inbred C57BL; Models, Biological; Molecular Targeted Therapy; Neoplasms; Sesquiterpenes; Systems Biology | 2017 |
Survival strategy of the salt-tolerant lactic acid bacterium, Tetragenococcus halophilus, to counteract koji mold, Aspergillus oryzae, in soy sauce brewing.
Topics: Amino Acid Sequence; Aspergillus oryzae; Enzyme Inhibitors; Fermentation; Food Industry; Glyceraldehyde-3-Phosphate Dehydrogenases; Lactic Acid; Lactobacillales; Microbial Sensitivity Tests; Salt Tolerance; Sequence Homology, Amino Acid; Sesquiterpenes; Soy Foods | 2018 |
Identification of a gene cluster for biosynthesis of the sesquiterpene antibiotic, heptelidic acid, in
Topics: Anti-Bacterial Agents; Aspergillus oryzae; Genes, Fungal; Glyceraldehyde-3-Phosphate Dehydrogenases; Multigene Family; Sesquiterpenes | 2019 |
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
Topics: Alkylation; Animals; Antimetabolites; Cysteine; Deoxyglucose; Down-Regulation; Endotoxemia; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase Type II; Oxidative Phosphorylation; RAW 264.7 Cells; Sesquiterpenes; Succinates | 2019 |
Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis.
Topics: Enzyme Inhibitors; Fatty Acids; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Glycolysis; Humans; MCF-7 Cells; Oxygen; Sesquiterpenes | 2020 |
A Condensed, Scalable Synthesis of Racemic Koningic Acid.
Topics: Glyceraldehyde-3-Phosphate Dehydrogenases; Sesquiterpenes | 2020 |
Expression of a heptelidic acid-insensitive recombinant GAPDH from Trichoderma virens, and its biochemical and biophysical characterization.
Topics: Enzyme Stability; Fungal Proteins; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Hypocrea; Molecular Docking Simulation; Recombinant Proteins; Sesquiterpenes | 2020 |
Deletion of the Trichoderma virens NRPS, Tex7, induces accumulation of the anti-cancer compound heptelidic acid.
Topics: Antibiotics, Antineoplastic; Fungal Proteins; Gene Deletion; Genes, Fungal; Multigene Family; Peptide Synthases; Sesquiterpenes; Trichoderma; Zea mays | 2020 |
Evaluation of heptelidic acid as a potential inhibitor for tau aggregation-induced Alzheimer's disease and associated neurotoxicity.
Topics: Animals; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Hydrophobic and Hydrophilic Interactions; Mice; Neuroprotective Agents; Protein Aggregates; Protein Structure, Secondary; Sesquiterpenes; tau Proteins | 2021 |
Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway.
Topics: Animals; Antineoplastic Agents; Aspergillus oryzae; Cell Line, Tumor; Humans; Intestinal Mucosa; Male; MAP Kinase Signaling System; Mice; Pancreatic Neoplasms; Probiotics; Sesquiterpenes | 2021 |
Antitumor activity of Koningic acid in thyroid cancer by inhibiting cellular glycolysis.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Glycolysis; Humans; Mice; Sesquiterpenes; Thyroid Neoplasms | 2022 |
Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control.
Topics: Animals; Glyceraldehyde-3-Phosphate Dehydrogenases; Mammals; Melanoma; Probiotics; Sesquiterpenes | 2022 |