heparitin-sulfate has been researched along with duramycin* in 1 studies
1 other study(ies) available for heparitin-sulfate and duramycin
| Article | Year |
|---|---|
T-cell immunoglobulin and mucin (TIM) contributes to the infection of human airway epithelial cells by pseudotype viruses containing Hantaan virus glycoproteins.
Hantaviruses are rodent-borne hemorrhagic fever viruses leading to serious diseases. Viral attachment and entry represent the first steps in virus transmission and are promising targets for antiviral therapeutic intervention. Here we investigated receptor use in human airway epithelium of the Old and New World hantaviruses Hantaan virus (HTNV) and Andes virus (ANDV). Using a biocontained recombinant vesicular stomatitis virus pseudotype platform, we provide first evidence for a role of the cellular phosphatidylserine (PS) receptors of the T-cell immunoglobulin and mucin (TIM) protein family in HTNV and ANDV infection. In line with previous studies, HTNV, but not ANDV, was able to use glycosaminoglycan heparan sulfate and α Topics: Animals; Axl Receptor Tyrosine Kinase; Bacteriocins; Cell Line, Tumor; Epithelial Cells; Hantaan virus; Haplorhini; Heparitin Sulfate; Hepatitis A Virus Cellular Receptor 1; Humans; Integrins; Membrane Glycoproteins; Membrane Proteins; Molecular Mimicry; Orthohantavirus; Peptides; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Virus; Respiratory Mucosa; Vesiculovirus; Viral Envelope Proteins | 2020 |