heparitin-sulfate and 6-deoxytalose

heparitin-sulfate has been researched along with 6-deoxytalose* in 1 studies

Other Studies

1 other study(ies) available for heparitin-sulfate and 6-deoxytalose

Article	Year
Synthesis of disaccharides containing 6-deoxy-α-L-talose as potential heparan sulfate mimetics. Molecules (Basel, Switzerland), 2012, Aug-15, Volume: 17, Issue:8 A 6-deoxy-α-L-talopyranoside acceptor was readily prepared from methyl α-L-rhamnopyranoside and glycosylated with thiogalactoside donors using NIS/TfOH as the promoter to give good yields of the desired a-linked disaccharide (69-90%). Glycosylation with a 2-azido-2-deoxy-D-glucosyl trichloroacetimidate donor was not completely stereoselective (α:β = 6:1), but the desired a-linked disaccharide could be isolated in good overall yield (60%) following conversion into its corresponding tribenzoate derivative. The disaccharides were designed to mimic the heparan sulfate (HS) disaccharide GlcN(2S,6S)-IdoA(2S). However, the intermediates readily derived from these disaccharides were not stable to the sulfonation/deacylation conditions required for their conversion into the target HS mimetics. Topics: Biomimetics; Deoxy Sugars; Disaccharides; Glycosylation; Heparitin Sulfate; Hexoses	2012

Article

Year

Synthesis of disaccharides containing 6-deoxy-α-L-talose as potential heparan sulfate mimetics.

Molecules (Basel, Switzerland), 2012, Aug-15, Volume: 17, Issue:8

A 6-deoxy-α-L-talopyranoside acceptor was readily prepared from methyl α-L-rhamnopyranoside and glycosylated with thiogalactoside donors using NIS/TfOH as the promoter to give good yields of the desired a-linked disaccharide (69-90%). Glycosylation with a 2-azido-2-deoxy-D-glucosyl trichloroacetimidate donor was not completely stereoselective (α:β = 6:1), but the desired a-linked disaccharide could be isolated in good overall yield (60%) following conversion into its corresponding tribenzoate derivative. The disaccharides were designed to mimic the heparan sulfate (HS) disaccharide GlcN(2S,6S)-IdoA(2S). However, the intermediates readily derived from these disaccharides were not stable to the sulfonation/deacylation conditions required for their conversion into the target HS mimetics.

Topics: Biomimetics; Deoxy Sugars; Disaccharides; Glycosylation; Heparitin Sulfate; Hexoses

2012