hemiasterlin and fosbretabulin

hemiasterlin has been researched along with fosbretabulin* in 1 studies

Other Studies

1 other study(ies) available for hemiasterlin and fosbretabulin

Article	Year
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives. Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9 A series of tubulysin analogs in which one of the stereogenic centers of tubuphenylalanine was eliminated were synthesized. All compounds were tested for antiproliferative activity towards ovarian cancer cells and for inhibition of tubulin polymerization. The dimethyl analogs were generally more active than the desmethyl analogs, and four analogs have tubulin polymerization IC(50) values similar to combretastatin A4 and the hemiasterlin analog HTI-286. Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Female; Humans; Inhibitory Concentration 50; Models, Chemical; Oligopeptides; Ovarian Neoplasms; Phenylalanine; Stilbenes; Structure-Activity Relationship; Tubulin Modulators	2008

Article

Year

Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives.

Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9

A series of tubulysin analogs in which one of the stereogenic centers of tubuphenylalanine was eliminated were synthesized. All compounds were tested for antiproliferative activity towards ovarian cancer cells and for inhibition of tubulin polymerization. The dimethyl analogs were generally more active than the desmethyl analogs, and four analogs have tubulin polymerization IC(50) values similar to combretastatin A4 and the hemiasterlin analog HTI-286.

Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Female; Humans; Inhibitory Concentration 50; Models, Chemical; Oligopeptides; Ovarian Neoplasms; Phenylalanine; Stilbenes; Structure-Activity Relationship; Tubulin Modulators

2008