Compounds > heme
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heme and spironolactone

heme has been researched along with spironolactone in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19903 (75.00)18.7374
1990's1 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gillette, JR; Guenthner, TM; Kon, H; Menard, RH1
Correia, MA; Decker, C; Sugiyama, K; Underwood, M1
Gillette, JR; Menard, RH; Stripp, B1
Correia, MA; He, K; Licad-Coles, E; Yin, H1

Other Studies

4 other study(ies) available for heme and spironolactone

ArticleYear
Studies on the destruction of adrenal and testicular cytochrome P-450 by spironolactone. Requirement for the 7alpha-thio group and evidence for the loss of the heme and apoproteins of cytochrome P-450.
    The Journal of biological chemistry, 1979, Mar-10, Volume: 254, Issue:5

    Topics: Adrenal Glands; Animals; Apoenzymes; Cytochrome P-450 Enzyme System; Dogs; Guinea Pigs; Heme; Male; Microsomes; Rats; Species Specificity; Spironolactone; Structure-Activity Relationship; Testis

1979
Inactivation of rat hepatic cytochrome P-450 by spironolactone.
    Biochemical and biophysical research communications, 1986, May-14, Volume: 136, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Dexamethasone; Drug Synergism; Heme; Male; Microsomes, Liver; NADP; Rats; Rats, Inbred Strains; Spironolactone; Time Factors; Troleandomycin

1986
Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism.
    Endocrinology, 1974, Volume: 94, Issue:6

    Topics: Animals; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Cytochromes; Dogs; Female; Guinea Pigs; Heme; Liver; Male; Methyltestosterone; Mice; Microsomes; Pregnenolone; Progesterone; Rabbits; Rats; Spironolactone; Steroid Hydroxylases; Testis; Testosterone

1974
Cytochrome P450 2C11: Escherichia coli expression, purification, functional characterization, and mechanism-based inactivation of the enzyme.
    Archives of biochemistry and biophysics, 1997, Feb-01, Volume: 338, Issue:1

    Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dicarbethoxydihydrocollidine; DNA, Complementary; Enzyme Inhibitors; Escherichia coli; Gene Expression; Heme; In Vitro Techniques; Male; Molecular Sequence Data; Rats; Recombinant Proteins; Sex Characteristics; Spironolactone; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases

1997