heme has been researched along with serine in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (12.00) | 18.7374 |
| 1990's | 9 (18.00) | 18.2507 |
| 2000's | 24 (48.00) | 29.6817 |
| 2010's | 9 (18.00) | 24.3611 |
| 2020's | 2 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dauter, Z; Oldfield, TJ; Petratos, K; Smerdon, SJ; Wilkinson, AJ; Wilson, KS | 1 |
| DeWitt, DL; Shimokawa, T; Smith, WL | 1 |
| Andrews, MJ; Armstrong, RL; DeWitt, DL; el-Harith, EA; Kraemer, SA; Smith, WL; Yao, EF | 1 |
| Brayer, GD; Funk, WD; Lo, TP; MacGillivray, RT; Mauk, AG; Mauk, MR | 1 |
| Brayer, GD; Louie, GV; Pielak, GJ; Smith, M | 1 |
| Margoliash, E; Putterman, GJ; Sherman, F | 1 |
| Gibson, F; Langman, L; Porra, RJ; Young, IG | 1 |
| Tanaka, Y | 1 |
| Lillich, TT; Ray, PH; White, DC | 1 |
| Carrell, RW; Owen, MC | 1 |
| Bukovska, G; Kery, V; Kraus, JP | 1 |
| Brantley, RE; Carver, TE; Hargrove, MS; Krzywda, S; Olson, JS; Smerdon, SJ; Wilkinson, AJ | 1 |
| Anderson, MM; Hazen, SL; Heinecke, JW; Hsu, FF | 1 |
| Fisher, MB; Fujii-Kuriyama, Y; Rettie, AE; Yokotani, N; Zheng, YM | 1 |
| Banerjee, R; Taoka, S; West, M | 1 |
| Adachi, S; Arakawa, H; Gomi, Y; Nakamura, H; Obayashi, E; Park, SY; Shimizu, H; Shiro, Y; Shoun, H | 1 |
| Jhee, KH; McPhie, P; Miles, EW | 1 |
| Lukat-Rodgers, GS; Rodgers, KR; Rusnak, F; Wengenack, NL | 2 |
| Adak, S; Johnson, JD; Santolini, J; Stuehr, DJ; Tikunova, S; Wang, Q | 1 |
| Bruno, S; Burkhard, P; Janosik, M; Kraus, JP; Mozzarelli, A; Schiaretti, F | 1 |
| Lee, D; Park, S; Shimizu, H; Shiro, Y; Shoun, H | 1 |
| Banerjee, R; Kabil, O; LoBrutto, R; Shoemaker, R; Toaka, S | 1 |
| Correia, MA; Maltby, D; Medzihradszky, KF; Wang, X | 1 |
| Banerjee, R; Taoka, S | 1 |
| Mauk, AG; Rosell, FI | 1 |
| Biel, S; Eichler, R; Gross, R; Pisa, R; Simon, J | 1 |
| Allen, JW; Ferguson, SJ; Fülöp, V; Gordon, EH; Hajdu, J; Higham, CW; Löfqvist, M; Richter, CD; Sjögren, T | 1 |
| Huang, ZX; Lu, JX; Wang, WH; Xie, Y; Yao, P | 1 |
| Colas, C; De Montellano, PR | 1 |
| Bidwai, A; Clarke, TA; Im, SC; Waskell, L | 1 |
| Brugna, M; Håkansson, KO; Tasse, L | 1 |
| Hu, Z; Lelli, KM; Maines, MD; Miralem, T; Torno, MD | 1 |
| Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F | 1 |
| Knappenberger, JA; Kuriakose, SA; Lecomte, JT; Nothnagel, HJ; Vu, BC; Vuletich, DA | 1 |
| El-Mashtoly, S; Hirai, K; Igarashi, J; Kitagawa, T; Martinkova, M; Saiful, I; Shimizu, T; Yamauchi, S | 1 |
| Chen, Z; Davis, MF; de Serrano, V; Franzen, S | 1 |
| Gurel, E; Mandaci, S; Ozturk, M; Watmough, NJ | 1 |
| Bhushan, A; Kaur, P; Sharma, S; Singh, AK; Singh, N; Singh, SB; Singh, TP; Srinivasan, A | 1 |
| Nakahara, A; Ozaki, S; Sakaguchi, C; Yoshiya, M | 1 |
| Bendall, DS; Howe, CJ; Mason, JM; Worrall, JA | 1 |
| Otzen, D; Schneider, D; Tome, L; Weber, M | 1 |
| Cui, FC; Liu, JY; Liu, W; Pan, XL | 1 |
| Banerjee, R; Yadav, PK | 1 |
| Bhagi-Damodaran, A; Lu, Y; Marshall, NM; Petrik, ID; Robinson, H | 1 |
| Chen, W; Chen, Y; Peng, H; Rizzo, AN; Zhuang, Y | 1 |
| Bar-Lev, L; Carmeliet, P; Chen, R; Dewerchin, M; Diehl, FF; Dubois, C; Eelen, G; Furuya, S; García-Caballero, M; Ghesquière, B; Goveia, J; Hirabayashi, Y; Kalucka, J; Keshet, E; Kumar, S; Li, X; Pircher, A; Schoonjans, L; Souffreau, J; Sullivan, MR; Vandekeere, S; Vander Heiden, MG; Vinckier, S | 1 |
| Arnold, FH; Chen, K; Huang, X; Renata, H; Wohlschlager, L; Zhang, RK | 1 |
| Astegno, A; Conter, C; Dominici, P; Fernández-Rodríguez, C; Fruncillo, S; Martínez-Cruz, LA | 1 |
| El Baze, A; Knizia, D; Lakhssassi, A; Lakhssassi, N; Meksem, J; Meksem, K | 1 |
50 other study(ies) available for heme and serine
| Article | Year |
|---|---|
High-resolution X-ray structures of pig metmyoglobin and two CD3 mutants: Mb(Lys45----Arg) and Mb(Lys45----Ser).
Topics: Animals; Arginine; Binding Sites; Crystallography; Fourier Analysis; Heme; Iron; Ligands; Lysine; Metmyoglobin; Mutation; Protein Conformation; Serine; Structure-Activity Relationship; Swine; X-Ray Diffraction | 1992 |
The aspirin and heme binding sites of PGG/H synthase.
Topics: Amino Acid Sequence; Animals; Aspirin; Binding Sites; Cyclooxygenase Inhibitors; Heme; Histidine; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Prostaglandin-Endoperoxide Synthases; Sequence Homology, Nucleic Acid; Serine; Sheep; Species Specificity | 1991 |
The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.
Topics: Amino Acid Sequence; Animals; Aspirin; Base Sequence; Binding Sites; Blotting, Western; DNA; Genetic Vectors; Heme; Mice; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Prostaglandin-Endoperoxide Synthases; Restriction Mapping; Sequence Homology, Nucleic Acid; Serine; Sheep | 1990 |
Mutagenic, electrochemical, and crystallographic investigation of the cytochrome b5 oxidation-reduction equilibrium: involvement of asparagine-57, serine-64, and heme propionate-7.
Topics: Amino Acid Sequence; Animals; Asparagine; Base Sequence; Cattle; Cytochromes b5; DNA; Electrochemistry; Escherichia coli; Heme; Molecular Sequence Data; Mutation; Oxidation-Reduction; Protein Conformation; Serine; X-Ray Diffraction | 1990 |
Role of phenylalanine-82 in yeast iso-1-cytochrome c and remote conformational changes induced by a serine residue at this position.
Topics: Cytochrome c Group; Cytochromes c; Electron Transport; Heme; Mutation; Oxidation-Reduction; Phenylalanine; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine | 1988 |
Identification of missense mutants by amino acid replacements in iso-1-cytochrome c from yeast.
Topics: Amino Acid Sequence; Binding Sites; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Thin Layer; Chymotrypsin; Cytochrome c Group; Electrophoresis; Genes; Heme; Hydrolysis; Isoleucine; Mutation; Peptides; Proline; RNA, Messenger; Saccharomyces cerevisiae; Serine; Threonine; Ultraviolet Rays | 1974 |
The role of ferric enterochelin esterase in enterochelin-mediated iron transport and ferrochelatase activity in Escherichia coli.
Topics: Benzoates; Biological Transport; Catechols; Escherichia coli; Esterases; Genetics, Microbial; Heme; Iron; Iron Chelating Agents; Kinetics; Lyases; Mutation; Serine; Spectrophotometry | 1972 |
The N-terminal structure of adult hemoglobin from Japanese monkey (Macaca fuscata fuscata) and the N-terminal amino acids of all the tryptic peptides from its alpha and beta polypeptide chains.
Topics: Amino Acids; Animals; Asparagine; Chromatography, Paper; Countercurrent Distribution; Globins; Haplorhini; Heme; Hemoglobins; Humans; Peptides; Serine; Spectrophotometry; Time Factors; Trypsin | 1969 |
Consequences of glycerol deprivation on the synthesis of membrane components in a glycerol auxotroph of Staphylococcus aureus.
Topics: Acetates; Bacterial Proteins; Carbon Isotopes; Carotenoids; Cell Membrane; Chromatography, Paper; Electron Transport; Fatty Acids; Fatty Acids, Nonesterified; Glucose; Glycerides; Glycerol; Glycine; Glycolipids; Heme; Levulinic Acids; Lipids; Mevalonic Acid; Phosphates; Phospholipids; Phosphorus Isotopes; Serine; Staphylococcus; Vitamin K | 1972 |
A new approach to haemoglobin variant identification. Haemoglobin Christchurch beta-71 (E15) phenylalanine leads to serine.
Topics: Adolescent; Amino Acid Sequence; Amino Acids; Anemia, Hemolytic; Anemia, Pernicious; Autoradiography; Carbon Isotopes; Chromatography, Thin Layer; Drug Stability; Electrophoresis; Erythrocytes; Female; Heme; Hemoglobinopathies; Hemoglobins; Hemoglobins, Abnormal; Hemolysis; Humans; Methods; New Zealand; Peptides; Phenylalanine; Serine | 1971 |
Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein.
Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Escherichia coli; Heme; Hemeproteins; Homocysteine; Humans; Kinetics; Liver; Pyridoxal Phosphate; Rats; Recombinant Proteins; Serine; Spectrophotometry; Sulfur | 1994 |
Serine92 (F7) contributes to the control of heme reactivity and stability in myoglobin.
Topics: Amino Acid Sequence; Animals; Crystallization; Drug Stability; Escherichia coli; Heme; Hemin; Hydrogen Bonding; Kinetics; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Myoglobin; Recombinant Fusion Proteins; Serine; Swine; X-Ray Diffraction | 1993 |
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated
Topics: Acetaldehyde; Acrolein; Aldehydes; Amino Acids; Catalase; Chlorides; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Heme; Humans; Hydrogen Peroxide; Hydroxy Acids; Hypochlorous Acid; Inflammation; Lysine; Mass Spectrometry; Molecular Structure; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Peroxidase; Serine; Threonine | 1997 |
Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Binding Sites; Catalysis; Cytochrome P-450 Enzyme System; Heme; Humans; Hydroxylation; Insecta; Lauric Acids; Mutagenesis, Site-Directed; Proline; Rabbits; Rats; Serine; Steroid Hydroxylases; Testosterone | 1998 |
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites.
Topics: Binding Sites; Carbon Monoxide; Catalysis; Cyanides; Cystathionine beta-Synthase; Enzyme Activation; Heme; Humans; Ligands; Pyridoxal Phosphate; Recombinant Proteins; Serine; Spectrometry, Fluorescence | 1999 |
Proton delivery in NO reduction by fungal nitric-oxide reductase. Cryogenic crystallography, spectroscopy, and kinetics of ferric-NO complexes of wild-type and mutant enzymes.
Topics: Aspartic Acid; Base Sequence; Catalysis; Crystallography, X-Ray; DNA Primers; Ferric Compounds; Fusarium; Heme; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Nitric Oxide; Oxidation-Reduction; Oxidoreductases; Protons; Serine | 2000 |
Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein.
Topics: Animals; Catalysis; Circular Dichroism; Cystathionine beta-Synthase; Heme; Humans; Models, Chemical; Protein Conformation; Rats; Saccharomyces cerevisiae; Serine; Spectrophotometry, Atomic | 2000 |
Spectroscopic comparison of the heme active sites in WT KatG and its S315T mutant.
Topics: Bacterial Proteins; Binding Sites; Electron Spin Resonance Spectroscopy; Ferric Compounds; Ferrous Compounds; Heme; Hemeproteins; Histidine; Ligands; Mutation; Mycobacterium tuberculosis; Peroxidases; Recombinant Proteins; Serine; Spectrum Analysis, Raman; Threonine | 2000 |
Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis.
Topics: Amino Acid Substitution; Aspartic Acid; Binding Sites; Calmodulin; Catalysis; Cytochrome c Group; Glycine max; Heme; Kinetics; Mutagenesis, Site-Directed; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Polymerase Chain Reaction; Recombinant Proteins; Serine | 2001 |
Functional properties of the active core of human cystathionine beta-synthase crystals.
Topics: Binding Sites; Carbon Monoxide; Cystathionine beta-Synthase; Heme; Homocysteine; Humans; Microspectrophotometry; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Pyridoxal Phosphate; Recombinant Proteins; Serine; Structure-Activity Relationship | 2001 |
Crystal structures of cytochrome P450nor and its mutants (Ser286-->Val, Thr) in the ferric resting state at cryogenic temperature: a comparative analysis with monooxygenase cytochrome P450s.
Topics: Binding Sites; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Electrons; Fusarium; Heme; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Mutation; Nitric Oxide; Oxidoreductases; Protein Conformation; Protein Structure, Secondary; Protons; Recombinant Proteins; Serine; Spectrophotometry; Temperature; Threonine; Valine; Water | 2000 |
Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme.
Topics: Amino Acid Sequence; Binding Sites; Cystathionine beta-Synthase; Dithiothreitol; Electron Spin Resonance Spectroscopy; Heme; Humans; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Sequence Data; Oxygen; Pyridoxal Phosphate; Serine; Yeasts | 2001 |
Carbon monoxide adducts of KatG and KatG(S315T) as probes of the heme site and isoniazid binding.
Topics: Amino Acid Substitution; Antitubercular Agents; Bacterial Proteins; Binding Sites; Carbon Monoxide; Electron Spin Resonance Spectroscopy; Ferric Compounds; Heme; Isoniazid; Mycobacterium tuberculosis; Peroxidases; Serine; Spectrum Analysis, Raman; Threonine | 2001 |
Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Inhibitors; Heme; Humans; Kinetics; Liver; Mass Spectrometry; Mixed Function Oxygenases; Models, Molecular; Mutagenesis; Okadaic Acid; Peptide Fragments; Phenylalanine; Phosphopeptides; Phosphorylation; Protein Conformation; Protein Kinase C; Protein Structure, Secondary; Rats; Recombinant Proteins; Sequence Deletion; Serine; Staurosporine | 2001 |
Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase.
Topics: Catalysis; Cystathionine; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Heme; Homocysteine; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Serine; Spectrophotometry; Time Factors | 2002 |
Spectroscopic properties of a mitochondrial cytochrome C with a single thioether bond to the heme prosthetic group.
Topics: Amino Acid Substitution; Binding Sites; Circular Dichroism; Cysteine; Cytochrome c Group; Cytochromes c; Electron Spin Resonance Spectroscopy; Heme; Isoenzymes; Mitochondria; Nuclear Magnetic Resonance, Biomolecular; Saccharomyces cerevisiae Proteins; Serine; Sulfides | 2002 |
Modification of heme c binding motifs in the small subunit (NrfH) of the Wolinella succinogenes cytochrome c nitrite reductase complex.
Topics: Amino Acid Motifs; Bacterial Proteins; Binding Sites; Culture Media; Cysteine; Cytochrome c Group; Cytochromes a1; Cytochromes c1; Heme; Mutagenesis, Site-Directed; Nitrate Reductases; Nitrites; Oxidation-Reduction; RNA-Binding Proteins; Serine; Transcription Factors; Wolinella | 2002 |
Structure and kinetic properties of Paracoccus pantotrophus cytochrome cd1 nitrite reductase with the d1 heme active site ligand tyrosine 25 replaced by serine.
Topics: Binding Sites; Cytochromes; Electron Transport Complex IV; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Heme; Kinetics; Ligands; Mutagenesis; Nitrite Reductases; Paracoccus; Protein Structure, Tertiary; Serine; Spectrometry, Mass, Electrospray Ionization; Tyrosine | 2003 |
The distinct heme coordination environments and heme-binding stabilities of His39Ser and His39Cys mutants of cytochrome b5.
Topics: Animals; Cattle; Cysteine; Cytochromes b5; Electrophoresis, Polyacrylamide Gel; Heme; Histidine; Mass Spectrometry; Mutation; Protein Denaturation; Serine; Temperature | 2003 |
Horseradish peroxidase mutants that autocatalytically modify their prosthetic heme group: insights into mammalian peroxidase heme-protein covalent bonds.
Topics: Animals; Carboxylic Acids; Catalysis; Cell Line; Chromatography, High Pressure Liquid; Cloning, Molecular; DNA; Electrophoresis, Polyacrylamide Gel; Genetic Variation; Glutamic Acid; Glycine; Heme; Horseradish Peroxidase; Hydrogen Peroxide; Hydrogen-Ion Concentration; Insecta; Kinetics; Leucine; Mass Spectrometry; Models, Chemical; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Peroxidase; Phenylalanine; Porphyrins; Protein Structure, Secondary; Serine; Spectrophotometry; Time Factors; Ultraviolet Rays | 2004 |
The role of the length and sequence of the linker domain of cytochrome b5 in stimulating cytochrome P450 2B4 catalysis.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Aspartic Acid; Catalysis; Cattle; Crystallography, X-Ray; Cytochrome P450 Family 2; Cytochromes b5; Databases as Topic; DNA, Complementary; Dose-Response Relationship, Drug; Electrons; Escherichia coli; Gene Deletion; Heme; Humans; Iron; Kinetics; Microsomes, Liver; Models, Chemical; Models, Molecular; Models, Statistical; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Rabbits; Sequence Homology, Amino Acid; Serine; Spectrophotometry | 2004 |
The three-dimensional structure of catalase from Enterococcus faecalis.
Topics: Amino Acid Sequence; Binding Sites; Catalase; Crystallography, X-Ray; Enterococcus faecalis; Heme; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Peptides; Protein Structure, Quaternary; Sequence Alignment; Serine; Solvents | 2004 |
Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Arsenites; Biliverdine; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Cell Survival; Cytochromes c; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Silencing; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Luciferases; Membrane Glycoproteins; Membrane Proteins; Oligonucleotides; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; Oxygen; Phosphorylation; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Retroviridae; RNA, Messenger; RNA, Small Interfering; Serine; Sodium Compounds; Threonine; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection | 2005 |
Proximal influences in two-on-two globins: effect of the Ala69Ser replacement on Synechocystis sp. PCC 6803 hemoglobin.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Cyanides; Ferric Compounds; Globins; Heme; Histidine; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Myoglobin; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Denaturation; Recombinant Proteins; Serine; Sperm Whale; Structure-Activity Relationship; Synechocystis; Temperature; Urea | 2006 |
Identification of Cys385 in the isolated kinase insertion domain of heme-regulated eIF2 alpha kinase (HRI) as the heme axial ligand by site-directed mutagenesis and spectral characterization.
Topics: Animals; Cysteine; eIF-2 Kinase; Electron Spin Resonance Spectroscopy; Gene Expression Regulation; Heme; Ligands; Mice; Mutagenesis, Insertional; Protein Binding; Protein Structure, Tertiary; Serine; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 2007 |
X-ray crystal structural analysis of the binding site in the ferric and oxyferrous forms of the recombinant heme dehaloperoxidase cloned from Amphitrite ornata.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Cysteine; Escherichia coli; Heme; Hemoglobins; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Conformation; Peroxidases; Polychaeta; Protein Conformation; Recombinant Proteins; Serine | 2007 |
Site-directed mutagenesis of five conserved residues of subunit i of the cytochrome cbb3 oxidase in Rhodobacter capsulatus.
Topics: Amino Acid Sequence; Amino Acids; Asparagine; Bacterial Proteins; Catalysis; Cytochromes c; Electron Transport Complex IV; Electrophoresis, Polyacrylamide Gel; Heme; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Subunits; Rhodobacter capsulatus; Sequence Homology, Amino Acid; Serine; Structure-Activity Relationship; Threonine | 2007 |
Crystal structure of lactoperoxidase at 2.4 A resolution.
Topics: Amino Acid Sequence; Amino Acids; Animals; Calcium; Crystallography, X-Ray; Disulfides; Goats; Heme; Humans; Hydrogen Bonding; Lactoperoxidase; Models, Molecular; Molecular Sequence Data; Phosphorylation; Sequence Analysis, Protein; Serine; Static Electricity; Substrate Specificity | 2008 |
Mutagenesis studies of human cystathionine beta-synthase: residues important for heme binding and substrate interactions.
Topics: Catalytic Domain; Cystathionine beta-Synthase; Heme; Homocysteine; Humans; Hydrogen Sulfide; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Serine; Spectrophotometry; Structure-Activity Relationship | 2010 |
The role of a disulfide bridge in the stability and folding kinetics of Arabidopsis thaliana cytochrome c(6A).
Topics: Amino Acid Sequence; Arabidopsis; Cyanobacteria; Cysteine; Cytochromes c6; Disulfides; Heme; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Protein Folding; Protein Structure, Tertiary; Serine; Thermodynamics | 2012 |
A Ser residue influences the structure and stability of a Pro-kinked transmembrane helix dimer.
Topics: Cell Membrane; Cytochrome b Group; Dimerization; Heme; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Mutation; Oxygen; Photosystem II Protein Complex; Proline; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Serine; Spectrophotometry | 2012 |
QM/MM study on the catalytic mechanism of heme-containing aliphatic aldoxime dehydratase.
Topics: Biocatalysis; Catalytic Domain; Crystallography, X-Ray; Electrons; Heme; Histidine; Hydro-Lyases; Hydrogen; Hydrogen Bonding; Iron; Models, Molecular; Molecular Structure; Nitrogen; Oxygen; Protein Conformation; Protons; Quantum Theory; Rotation; Serine; Water | 2012 |
Detection of reaction intermediates during human cystathionine β-synthase-monitored turnover and H2S production.
Topics: Cystathionine beta-Synthase; Cysteine; Heme; Homocysteine; Humans; Hydrogen Sulfide; Kinetics; Serine | 2012 |
Systematic tuning of heme redox potentials and its effects on O2 reduction rates in a designed oxidase in myoglobin.
Topics: Alanine; Animals; Binding Sites; Biocatalysis; Copper; Electron Transport Complex IV; Heme; Histidine; Hydrogen Bonding; Male; Models, Molecular; Myoglobin; Oxidation-Reduction; Oxygen; Protein Engineering; Serine; Spermatozoa; Whales | 2014 |
The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain.
Topics: Animals; Biopterins; Calmodulin; Cattle; Cysteine; Electron Spin Resonance Spectroscopy; Heme; Mutation; Nitric Oxide Synthase Type III; Oxidation-Reduction; Phosphorylation; Protein Structure, Tertiary; Serine; Superoxides | 2015 |
Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.
Topics: Apoptosis; Carbohydrate Metabolism, Inborn Errors; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dietary Supplements; Endothelial Cells; Gene Knockdown Techniques; Heme; Hemin; Human Umbilical Vein Endothelial Cells; Humans; Microcephaly; Mitochondria; Mitophagy; Neovascularization, Physiologic; Oxidative Stress; Phosphoglycerate Dehydrogenase; Protein Biosynthesis; Psychomotor Disorders; Purines; Reactive Oxygen Species; Seizures; Serine | 2018 |
Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp
Topics: Alkylation; Animals; Biocatalysis; Carbon; Coenzymes; Cysteine; Cytochrome P-450 Enzyme System; Directed Molecular Evolution; Heme; Hydrogen; Iron; Male; Methane; Serine; Substrate Specificity; Vitamin B 12 | 2019 |
Cystathionine β-synthase is involved in cysteine biosynthesis and H
Topics: Biocatalysis; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; DNA, Complementary; Genes, Protozoan; Heme; Homocysteine; Hydrogen Sulfide; Kinetics; Serine; Toxoplasma | 2020 |
Proteomic, Transcriptomic, Mutational, and Functional Assays Reveal the Involvement of Both THF and PLP Sites at the GmSHMT08 in Resistance to Soybean Cyst Nematode.
Topics: Animals; Carbon; Cysts; Glycine; Glycine Hydroxymethyltransferase; Glycine max; Glyoxylates; Heme; Methionine; Nematoda; Plant Diseases; Proteomics; Purines; Pyridoxal Phosphate; Serine; Tetrahydrofolates; Transcriptome | 2022 |