Page last updated: 2024-08-23

heme and pyridoxal phosphate

heme has been researched along with pyridoxal phosphate in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	15 (28.30)	18.7374
1990's	8 (15.09)	18.2507
2000's	17 (32.08)	29.6817
2010's	9 (16.98)	24.3611
2020's	4 (7.55)	2.80

Authors

Authors	Studies
Cartwright, GE; Deiss, A	1
Gouji, J; Kondou, M; Murakami, R; Nakamura, H; Takumi, T	1
Khachatur'ian, AA; Smirnov, IV	1
Billi de Catabbi, S; Ríos de Molina, MC; San Martín de Viale, LC	1
Durst, F; Jones, OT; Werck-Reichhart, D	1
Litwack, G; Rosenfield, S	1
Bottomley, SS; Smithee, GA	1
Aoki, Y; Nakao, K; Takaku, F; Wada, O; Yano, Y	1
Anderson, BB; Mollin, DL	1
Hammaker, LE; Marver, HS; Scholnick, PL	1
Ali, MA; Brain, MC; White, JM	1
Palma-Carlos, AG; Palma-Carlos, ML	1
Weintraub, LR	1
Gibson, QH	1
Neuwirt, J; Ponka, P	1
Barnes, K; de Souza, P; Jacobs, A; Kaaba, S; May, A	1
Pasanen, AV; Salmi, M; Tenhunen, R; Vuopio, P	1
Bottomley, SS; Buchanan, GR; Nitschke, R	1
Ferreira, GC; Gong, J	1
Fitzsimons, E; May, A	1
Bukovska, G; Kery, V; Kraus, JP	1
Kery, V; Kraus, JP; Poneleit, L	1
Banerjee, R; Taoka, S; West, M	1
Finkelstein, JD	1
Azhigirova, MA; Berkovsky, AL; Milder, OB; Oshtrakh, MI; Semionkin, VA; Vyazova, EP	1
Bruno, S; Burkhard, P; Janosik, M; Kraus, JP; Mozzarelli, A; Schiaretti, F	1
Janosík, M; Kery, V; Kraus, JP; Maclean, KN; Oliveriusová, J	1
Banerjee, R; Green, EL; Loehr, TM; Taoka, S	1
Banerjee, R; Kabil, O; LoBrutto, R; Shoemaker, R; Toaka, S	1
Burkhard, P; Janosik, M; Kery, V; Kraus, JP; Meier, M	1
Banerjee, R; LoBrutto, R; Ojha, S; Wu, J	1
Banerjee, R; Kabil, O; Lepore, BW; Ojha, S; Ringe, D; Taoka, S	1
Kimura, H	1
Banerjee, R; Evande, R; Ojha, S	1
Banerjee, R; Zou, CG	1
Astner, I; Heinz, DW; Jahn, D; Schubert, WD; Schulze, JO; van den Heuvel, J	1
Banerjee, R; Madzelan, P; Singh, S	1
Inada, A; Ozaki, S; Sada, K	1
Aitken, SM; Belew, MS; Quazi, FI; Willmore, WG	1
Banerjee, R; Madzelan, P; Singh, S; Spiro, TG; Weeks, CL	1
Burstyn, JN; Freeman, KM; Kraus, JP; Majtan, T; Smith, AT; Su, Y	1
Burstyn, JN; Kraus, JP; Majtan, T; Smith, AT; Stevens, DJ; Su, Y	1
Banerjee, R; Xie, P; Yadav, PK	1
Banerjee, R; Gherasim, C; Kabil, O; Niu, WN; Yadav, PK	1
Bellstedt, P; Goradia, N; Imhof, D; Kumar, A; Ohlenschläger, O; Ramachandran, R; Wißbrock, A	1
Baker, TA; Brown, BL; Kardon, JR; Sauer, RT	1
Berkowitz, DB; Hill, M; Kreinbring, CA; Liu, C; Liu, D; McCune, CD; Petsko, GA; Ringe, D; Tu, Y	1
Hori, H; Ikushiro, H; Kamiya, N; Miyahara, I; Nagami, A; Sawai, T; Shimeno, Y; Takai, T; Yano, T	1
Ferreira, GC; Hunter, GA; Jiang, RHY; Na, I; Stojanovski, BM; Uversky, VN	1
Aarsand, AK; Aguilera, P; Brunet, M; Deulofeu, R; García-Villoria, J; Gómez-Gómez, À; Pozo, OJ; Sandberg, S; To-Figueras, J; Wijngaard, R	1
Ali, ME; Bhatt, A; Mukhopadhyaya, A	1
El Baze, A; Knizia, D; Lakhssassi, A; Lakhssassi, N; Meksem, J; Meksem, K	1
Brown, BL; Tran, JU	1

Reviews

8 review(s) available for heme and pyridoxal phosphate

Article	Year
Sideroblasts, siderocytes, and sideroblastic anemia. The New England journal of medicine, 1975, Jan-23, Volume: 292, Issue:4 Topics: 5-Aminolevulinate Synthetase; Anemia, Hemolytic; Anemia, Sideroblastic; Animals; Bloodletting; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cytoplasm; Endoplasmic Reticulum; Erythrocyte Count; Erythrocytes; Ferritins; Heme; Humans; In Vitro Techniques; Iron; Male; Mitochondria; Pyridoxal Phosphate; Reticulocytes; Spleen; Splenectomy; Swine	1975
5-Aminolevulinate synthase and the first step of heme biosynthesis. Journal of bioenergetics and biomembranes, 1995, Volume: 27, Issue:2 Topics: 5-Aminolevulinate Synthetase; Amino Acid Sequence; Animals; Cloning, Molecular; Erythrocytes; Heme; Humans; Kinetics; Liver; Mitochondria; Molecular Sequence Data; Pyridoxal Phosphate; Sequence Homology, Amino Acid; Substrate Specificity	1995
Sideroblastic anaemia. Bailliere's clinical haematology, 1994, Volume: 7, Issue:4 Topics: 5-Aminolevulinate Synthetase; Anemia, Sideroblastic; Biological Transport; Chloramphenicol; Copper; DNA, Mitochondrial; Erythrocytes; Ferrochelatase; Genetic Linkage; Globins; Heme; Humans; Hydroxymethylbilane Synthase; Iron; Mutation; Pyridoxal Phosphate; Syndrome; X Chromosome	1994
Pathways and regulation of homocysteine metabolism in mammals. Seminars in thrombosis and hemostasis, 2000, Volume: 26, Issue:3 Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Heme; Homocysteine; Isoenzymes; Kinetics; Mammals; Methionine; Methionine Adenosyltransferase; Organ Specificity; Oxidation-Reduction; Pyridoxal Phosphate; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur; Tetrahydrofolates	2000
Hydrogen sulfide as a neuromodulator. Molecular neurobiology, 2002, Volume: 26, Issue:1 Topics: Animals; Brain Chemistry; Calcium; Calmodulin; Cattle; Central Nervous System Diseases; Corticotropin-Releasing Hormone; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cysteine; Heme; Hippocampus; Humans; Hydrogen Sulfide; Hypothalamus; Long-Term Potentiation; Mice; Muscle Proteins; Muscle Relaxation; Nerve Tissue Proteins; Neurotransmitter Agents; Nitric Oxide; Pyridoxal Phosphate; Rats; Synaptic Transmission	2002
Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein. Archives of biochemistry and biophysics, 2005, Jan-01, Volume: 433, Issue:1 Topics: Alanine; Allosteric Regulation; Amino Acid Motifs; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Crystallography, X-Ray; Cystathionine beta-Synthase; DNA Mutational Analysis; Enzyme Activation; Heme; Hemeproteins; Humans; Kinetics; Models, Chemical; Models, Molecular; Models, Structural; Molecular Sequence Data; Molecular Structure; Molecular Weight; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Pyridoxal Phosphate; Sequence Homology, Amino Acid; Substrate Specificity; Threonine	2005
Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase. Natural product reports, 2007, Volume: 24, Issue:3 Topics: Carbon Monoxide; Catalysis; Cystathionine beta-Synthase; Heme; Hemeproteins; Humans; Iron; Models, Molecular; Nitric Oxide; Pyridoxal Phosphate	2007
5-Aminolevulinate synthase catalysis: The catcher in heme biosynthesis. Molecular genetics and metabolism, 2019, Volume: 128, Issue:3 Topics: 5-Aminolevulinate Synthetase; Biosynthetic Pathways; Catalysis; Heme; Humans; Kinetics; Molecular Dynamics Simulation; Protein Conformation; Pyridoxal Phosphate; Substrate Specificity	2019

Other Studies

45 other study(ies) available for heme and pyridoxal phosphate

Article	Year
Sideroblastic anemia showing unique response to pyridoxine. The American journal of pediatric hematology/oncology, 1991,Fall, Volume: 13, Issue:3 Topics: 5-Aminolevulinate Synthetase; Anemia, Sideroblastic; Erythroblasts; Heme; Humans; Infant; Iron; Male; Pyridoxal Phosphate; Pyridoxine	1991
[The transhemenation process of bovine and human hemoglobin polymers under conditions simulating the situation in the circulatory bed]. Biulleten' eksperimental'noi biologii i meditsiny, 1991, Volume: 112, Issue:11 Topics: Animals; Blood Substitutes; Cattle; Heme; Hemoglobins; Humans; Male; Methemoglobin; Models, Biological; Pyridoxal Phosphate	1991
Liver ferrochelatase from normal and hexachlorobenzene porphyric rats. Mechanism of drug action. The International journal of biochemistry, 1991, Volume: 23, Issue:7-8 Topics: Animals; Binding Sites; Chromatography, Gel; Copper; Copper Sulfate; Female; Ferrochelatase; Heme; Hexachlorobenzene; Hot Temperature; Liver; Pentachlorophenol; Porphyrias; Porphyrins; Protein Conformation; Pyridoxal Phosphate; Rats; Rats, Inbred Strains; Spectrophotometry	1991
Haem synthesis during cytochrome P-450 induction in higher plants. 5-Aminolaevulinic acid synthesis through a five-carbon pathway in Helianthus tuberosus tuber tissues aged in the dark. The Biochemical journal, 1988, Jan-15, Volume: 249, Issue:2 Topics: Allylglycine; Aminolevulinic Acid; Chlorophyll; Cyclohexanecarboxylic Acids; Cytochrome P-450 Enzyme System; Darkness; Electron Transport; Enzyme Induction; Helianthus; Heme; Levulinic Acids; Light; Peroxidases; Plant Proteins; Pyridoxal Phosphate	1988
Coenzyme dissociation, a possible determinant of short half-life of inducible enzymes in mammalian liver. Biochemical and biophysical research communications, 1973, May-01, Volume: 52, Issue:1 Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Binding Sites; Carboxy-Lyases; Charcoal; Coenzymes; Cytosol; Enzyme Induction; Half-Life; Heme; Kinetics; Liver; Ornithine; Protein Binding; Protein Denaturation; Pyridoxal Phosphate; Rats; Time Factors; Tryptophan Oxygenase; Tyrosine Transaminase	1973
Characterization and measurement of delta-aminolaevulinate synthetase in bone marrow cell mitochondria. Biochimica et biophysica acta, 1968, Apr-24, Volume: 159, Issue:1 Topics: Acyltransferases; Amino Acids; Animals; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Coenzyme A; Edetic Acid; Glycine; Heme; Hemoglobins; Hot Temperature; Iron Isotopes; Ketoglutaric Acids; Levulinic Acids; Lyases; Magnesium; Methods; Microchemistry; Microscopy, Electron; Mitochondria; NAD; Porphyrins; Pyridoxal Phosphate; Rabbits; Succinate Dehydrogenase; Succinates	1968
-Aminolevulinic acid synthetase activity of human bone marrow erythroid cells in various hematological disorders. The Tohoku journal of experimental medicine, 1972, Volume: 107, Issue:3 Topics: 5-Aminolevulinate Synthetase; Anemia, Hypochromic; Anemia, Sideroblastic; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Coenzyme A; Edetic Acid; Erythrocytes; Glycine; Hematologic Diseases; Hematopoietic Stem Cells; Heme; Humans; Hydrogen-Ion Concentration; Ketoglutaric Acids; Levulinic Acids; Magnesium; Porphyrias; Pyridoxal Phosphate; Thalassemia	1972
Red-cell metabolism of pyridoxine in sideroblastic anaemias and related anaemias. British journal of haematology, 1972, Volume: 23 Topics: Adenosine Triphosphate; Adult; Aged; Anemia, Hypochromic; Anemia, Sideroblastic; Biological Assay; Erythrocytes, Abnormal; Heme; Humans; In Vitro Techniques; Iron; Lacticaseibacillus casei; Middle Aged; Mitochondria; Pyridoxal; Pyridoxal Phosphate; Pyridoxine; Thalassemia; Vitamin B 6 Deficiency	1972
Soluble -aminolevulinic acid synthetase of rat liver. II. Studies related to the mechanism of enzyme action and hemin inhibition. The Journal of biological chemistry, 1972, Jul-10, Volume: 247, Issue:13 Topics: 5-Aminolevulinate Synthetase; Acyltransferases; Animals; Binding Sites; Carbon Isotopes; Coenzyme A; Cytoplasm; Ethers; Feedback; Glycine; Heme; Kinetics; Liver; Male; Models, Chemical; Porphyrins; Pyridoxal Phosphate; Rats; Schiff Bases; Solubility; Structure-Activity Relationship; Succinates; Sulfhydryl Compounds; Sulfhydryl Reagents	1972
Alpha- and beta- peptide chain synthesis in sideroblastic anaemia. British journal of haematology, 1969, Volume: 17, Issue:6 Topics: Amino Acids; Anemia, Sideroblastic; Heme; Hemoglobins; Humans; In Vitro Techniques; Leucine; Levulinic Acids; Peptide Biosynthesis; Pyridoxal Phosphate; Reticulocytes; Tritium	1969
[Effect of the concentration of iron and pyridoxal phosphate on the ferrochelatase activity of erythrocytes]. Sangre, 1970, Volume: 15, Issue:2 Topics: Erythrocytes; Heme; Humans; In Vitro Techniques; Iron; Iron Chelating Agents; Lyases; Porphyrins; Pyridoxal Phosphate	1970
The continuing saga of the sideroblast. The New England journal of medicine, 1970, Aug-27, Volume: 283, Issue:9 Topics: Alcoholism; Anemia, Sideroblastic; Bone Marrow; Ethanol; Folic Acid Deficiency; Heme; Humans; Iron; Pyridoxal Phosphate; Pyridoxine	1970
Organic phosphates and ligand binding in hemoglobin. Biochemical and biophysical research communications, 1970, Sep-30, Volume: 40, Issue:6 Topics: Chemical Phenomena; Chemistry; Glycerophosphates; Heme; Hemoglobins; Kinetics; Models, Chemical; Oxygen; Polymers; Protein Binding; Pyridoxal Phosphate; Sulfites; Thermodynamics	1970
Regulation of iron entry into reticulocytes. II. Relationship between hemoglobin synthesis and entry of iron into reticulocytes. Biochimica et biophysica acta, 1971, Feb-23, Volume: 230, Issue:2 Topics: Animals; Biological Transport; Carbon Isotopes; Cell Membrane; Chloramphenicol; Cycloheximide; Emetine; Fluorides; Globins; Glycine; Heme; Hemoglobins; In Vitro Techniques; Iron; Iron Isotopes; Isoniazid; Penicillamine; Puromycin; Pyridoxal Phosphate; Rabbits; Reticulocytes; Tryptamines	1971
Erythroblast iron metabolism in sideroblastic marrows. British journal of haematology, 1982, Volume: 52, Issue:4 Topics: Adult; Aged; Aminolevulinic Acid; Anemia, Sideroblastic; Bone Marrow; Cytoplasm; Erythroblasts; Erythrocyte Indices; Erythrocytes; Erythropoietin; Female; Ferritins; Heme; Humans; Iron; Male; Middle Aged; Mitochondria; Pyridoxal Phosphate	1982
Haema synthesis during pyridoxine therapy in two families with different types of hereditary sideroblastic anaemia. Annals of clinical research, 1982, Volume: 14, Issue:2 Topics: 5-Aminolevulinate Synthetase; Anemia, Sideroblastic; Coproporphyrins; Erythrocytes; Female; Heme; Humans; Male; Protoporphyrins; Pyridoxal Phosphate; Pyridoxine	1982
Bone marrow delta-aminolaevulinate synthase deficiency in a female with congenital sideroblastic anemia. Blood, 1980, Volume: 55, Issue:1 Topics: 5-Aminolevulinate Synthetase; Administration, Oral; Anemia, Sideroblastic; Bone Marrow; Child, Preschool; Female; Heme; Humans; Injections, Intramuscular; Karyotyping; Pyridoxal Phosphate; Pyridoxine	1980
Transsulfuration depends on heme in addition to pyridoxal 5'-phosphate. Cystathionine beta-synthase is a heme protein. The Journal of biological chemistry, 1994, Oct-14, Volume: 269, Issue:41 Topics: Animals; Cystathionine; Cystathionine beta-Synthase; Escherichia coli; Heme; Hemeproteins; Homocysteine; Humans; Kinetics; Liver; Pyridoxal Phosphate; Rats; Recombinant Proteins; Serine; Spectrophotometry; Sulfur	1994
Trypsin cleavage of human cystathionine beta-synthase into an evolutionarily conserved active core: structural and functional consequences. Archives of biochemistry and biophysics, 1998, Jul-15, Volume: 355, Issue:2 Topics: Amino Acid Sequence; Binding Sites; Conserved Sequence; Cystathionine beta-Synthase; Enzyme Activation; Heme; Hot Temperature; Humans; Hydrolysis; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Protein Denaturation; Pyridoxal Phosphate; Recombinant Proteins; S-Adenosylmethionine; Solvents; Spectrometry, Fluorescence; Trypsin; Tryptophan	1998
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites. Biochemistry, 1999, Mar-02, Volume: 38, Issue:9 Topics: Binding Sites; Carbon Monoxide; Catalysis; Cyanides; Cystathionine beta-Synthase; Enzyme Activation; Heme; Humans; Ligands; Pyridoxal Phosphate; Recombinant Proteins; Serine; Spectrometry, Fluorescence	1999
Characterization of the heme iron in pyridoxylated hemoglobin cross-linked by glutaraldehyde using Mössbauer spectroscopy. International journal of biological macromolecules, 2000, Oct-10, Volume: 28, Issue:1 Topics: Adult; Cross-Linking Reagents; Electrochemistry; Glutaral; Heme; Hemoglobins; Humans; In Vitro Techniques; Iron; Oxygen; Oxyhemoglobins; Pyridoxal Phosphate; Spectroscopy, Mossbauer; Stereoisomerism	2000
Functional properties of the active core of human cystathionine beta-synthase crystals. The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1 Topics: Binding Sites; Carbon Monoxide; Cystathionine beta-Synthase; Heme; Homocysteine; Humans; Microspectrophotometry; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Pyridoxal Phosphate; Recombinant Proteins; Serine; Structure-Activity Relationship	2001
Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine beta-synthase. Journal of inorganic biochemistry, 2000, Aug-31, Volume: 81, Issue:3 Topics: Amino Acid Sequence; Catalysis; Cell Division; Cloning, Molecular; Cystathionine beta-Synthase; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Humans; Kinetics; Ligands; Mass Spectrometry; Molecular Sequence Data; Pyridoxal Phosphate; Recombinant Proteins; S-Adenosylmethionine; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Sulfur; Time Factors; Ultraviolet Rays	2000
Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase. Identification of the Fe-S(Cys) vibration in the six-coordinate low-spin heme. Biochemistry, 2001, Jan-16, Volume: 40, Issue:2 Topics: Binding, Competitive; Carbon Monoxide; Cystathionine beta-Synthase; Cysteine; Ferric Compounds; Ferrous Compounds; Heme; Homocysteine; Humans; Iron-Sulfur Proteins; Ligands; Mercuric Chloride; Molybdenum; Oxidation-Reduction; Protein Binding; Pyridoxal Phosphate; Spectrum Analysis, Raman	2001
Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme. The Journal of biological chemistry, 2001, Jun-01, Volume: 276, Issue:22 Topics: Amino Acid Sequence; Binding Sites; Cystathionine beta-Synthase; Dithiothreitol; Electron Spin Resonance Spectroscopy; Heme; Humans; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Sequence Data; Oxygen; Pyridoxal Phosphate; Serine; Yeasts	2001
Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein. The EMBO journal, 2001, Aug-01, Volume: 20, Issue:15 Topics: Amino Acid Sequence; Animals; Binding Sites; Cystathionine beta-Synthase; Heme; Hemeproteins; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis; Oxidoreductases; Protein Structure, Secondary; Pyridoxal Phosphate; Rabbits	2001
Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase. Biochemistry, 2002, Apr-09, Volume: 41, Issue:14 Topics: Amino Acid Substitution; Binding Sites; Cystathionine beta-Synthase; Genetic Variation; Heme; Humans; Kinetics; Ligands; Models, Molecular; Protein Conformation; Pyridoxal Phosphate; Recombinant Fusion Proteins; Recombinant Proteins; Spectrophotometry	2002
Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme. Biochemistry, 2002, Aug-20, Volume: 41, Issue:33 Topics: Amino Acid Motifs; Binding Sites; Catalysis; Catalytic Domain; Crystallization; Crystallography, X-Ray; Cystathionine beta-Synthase; Cysteine; Heme; Humans; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases; Pyridoxal Phosphate; Sequence Deletion	2002
Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base. Archives of biochemistry and biophysics, 2004, Jul-15, Volume: 427, Issue:2 Topics: Binding Sites; Cystathionine beta-Synthase; Enzyme Activation; Genetic Variation; Heme; Humans; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyridoxal Phosphate; Recombinant Proteins; Spectrophotometry, Ultraviolet; Stereoisomerism	2004
Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. The EMBO journal, 2005, Sep-21, Volume: 24, Issue:18 Topics: 5-Aminolevulinate Synthetase; Acyl Coenzyme A; Amino Acid Sequence; Anemia, Sideroblastic; Binding Sites; Crystallography, X-Ray; Dimerization; Genetic Diseases, X-Linked; Glycine; Heme; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Quaternary; Pyridoxal Phosphate; Rhodobacter capsulatus; Sequence Alignment; Substrate Specificity	2005
Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations. Bioscience, biotechnology, and biochemistry, 2008, Volume: 72, Issue:9 Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Catalysis; Cystathionine; Cystathionine beta-Synthase; Heme; Humans; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyridoxal Phosphate; Recombinant Proteins	2008
Kinetic characterization of recombinant human cystathionine beta-synthase purified from E. coli. Protein expression and purification, 2009, Volume: 64, Issue:2 Topics: Catalysis; Chromatography, Affinity; Cystathionine beta-Synthase; Escherichia coli; Heme; Histidine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Pyridoxal Phosphate; Recombinant Proteins	2009
Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy. Journal of the American Chemical Society, 2009, Sep-09, Volume: 131, Issue:35 Topics: Cystathionine beta-Synthase; Enzyme Activation; Heme; Humans; Isomerism; Models, Molecular; Protein Conformation; Pyridoxal Phosphate; Schiff Bases; Spectrometry, Fluorescence; Spectrum Analysis, Raman	2009
Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif. Inorganic chemistry, 2011, May-16, Volume: 50, Issue:10 Topics: Circular Dichroism; Cloning, Molecular; Cobalt; Coordination Complexes; Cystathionine beta-Synthase; Cysteine; Escherichia coli; Heme; Hemeproteins; Histidine; Humans; Hydrogen-Ion Concentration; Ligands; Models, Molecular; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Pyridoxal Phosphate; Recombinant Proteins; Spectrophotometry, Atomic	2011
Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase. Biochemistry, 2012, Aug-14, Volume: 51, Issue:32 Topics: Catalytic Domain; Circular Dichroism; Cystathionine beta-Synthase; Electron Spin Resonance Spectroscopy; Enzyme Stability; Ferrous Compounds; Heme; Homocystinuria; Humans; Models, Molecular; Mutation; Oxidation-Reduction; Protein Binding; Pyridoxal Phosphate; Spectrometry, Fluorescence; Spectrum Analysis, Raman; Temperature	2012
Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase. The Journal of biological chemistry, 2012, Nov-02, Volume: 287, Issue:45 Topics: Allosteric Regulation; Binding Sites; Cystathionine beta-Synthase; Heme; Homocystinuria; Humans; Hydrogen Peroxide; Iron; Isomerism; Kinetics; Mutation; Oxidation-Reduction; Protein Carbonylation; Pyridoxal Phosphate; S-Adenosylmethionine; Spectrometry, Fluorescence; Threonine	2012
Nitrite reductase activity and inhibition of H₂S biogenesis by human cystathionine ß-synthase. PloS one, 2014, Volume: 9, Issue:1 Topics: Cystathionine beta-Synthase; Electron Spin Resonance Spectroscopy; Heme; Humans; Hydrogen Sulfide; Iron; Models, Biological; Nitric Oxide; Nitrite Reductases; Nitrites; Oxidation-Reduction; Pyridoxal Phosphate; Reducing Agents	2014
Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase. Scientific reports, 2018, 02-06, Volume: 8, Issue:1 Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Cloning, Molecular; Cystathionine beta-Synthase; Escherichia coli; Gene Expression; Genetic Vectors; Heme; Humans; Intrinsically Disordered Proteins; Kinetics; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Binding; Protein Interaction Domains and Motifs; Pyridoxal Phosphate; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Thermodynamics	2018
Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme. Structure (London, England : 1993), 2018, 04-03, Volume: 26, Issue:4 Topics: 5-Aminolevulinate Synthetase; Amino Acid Motifs; Amino Acid Substitution; Aminolevulinic Acid; Catalytic Domain; Cloning, Molecular; Coenzymes; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Heme; Kinetics; Mitochondria; Models, Molecular; Mutation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Subunits; Pyridoxal Phosphate; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity	2018
Crystal Structures of Cystathionine β-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time. Biochemistry, 2018, 06-05, Volume: 57, Issue:22 Topics: Catalysis; Cystathionine beta-Synthase; Cysteine; Heme; Humans; Kinetics; Models, Molecular; Oxidation-Reduction; Pyridoxal Phosphate; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins	2018
Heme-dependent Inactivation of 5-Aminolevulinate Synthase from Caulobacter crescentus. Scientific reports, 2018, 09-21, Volume: 8, Issue:1 Topics: 5-Aminolevulinate Synthetase; Amino Acid Sequence; Bacterial Proteins; Caulobacter crescentus; Coenzymes; Heme; Histidine; Humans; Ligands; Pyridoxal Phosphate; RNA, Messenger	2018
Dysregulation of homocysteine homeostasis in acute intermittent porphyria patients receiving heme arginate or givosiran. Journal of inherited metabolic disease, 2021, Volume: 44, Issue:4 Topics: Acetylgalactosamine; Adult; Arginine; Cystathionine beta-Synthase; Female; Folic Acid; Heme; Homeostasis; Homocysteine; Homocystinuria; Humans; Hydroxymethylbilane Synthase; Hyperhomocysteinemia; Male; Methionine; Middle Aged; Porphyria, Acute Intermittent; Pyridoxal Phosphate; Pyrrolidines; Young Adult	2021
α-Helix in Cystathionine β-Synthase Enzyme Acts as an Electron Reservoir. The journal of physical chemistry. B, 2022, 07-07, Volume: 126, Issue:26 Topics: Cystathionine beta-Synthase; Electrons; Heme; Humans; Protein Conformation, alpha-Helical; Pyridoxal Phosphate	2022
Proteomic, Transcriptomic, Mutational, and Functional Assays Reveal the Involvement of Both THF and PLP Sites at the GmSHMT08 in Resistance to Soybean Cyst Nematode. International journal of molecular sciences, 2022, Sep-24, Volume: 23, Issue:19 Topics: Animals; Carbon; Cysts; Glycine; Glycine Hydroxymethyltransferase; Glycine max; Glyoxylates; Heme; Methionine; Nematoda; Plant Diseases; Proteomics; Purines; Pyridoxal Phosphate; Serine; Tetrahydrofolates; Transcriptome	2022
The yeast ALA synthase C-terminus positively controls enzyme structure and function. Protein science : a publication of the Protein Society, 2023, Volume: 32, Issue:4 Topics: 5-Aminolevulinate Synthetase; Catalytic Domain; Heme; Humans; Pyridoxal Phosphate; Saccharomyces cerevisiae	2023