Compounds > heme
Page last updated: 2024-08-23

heme and oxadiazoles

heme has been researched along with oxadiazoles in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's5 (25.00)18.2507
2000's6 (30.00)29.6817
2010's6 (30.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Grab, LA; Mackie, JE; Marks, GS; Ortiz de Montellano, PR1
Grab, LA; Ortiz de Montellano, PR; Swanson, BA1
Behrends, S; Koesling, D; Mayer, B; Schmidt, K; Schrammel, A1
Axelsson, O; Bang, L; Busse, R; Drejer, J; Moldt, P; Mülsch, A; Nielsen-Kudsk, JE; Olesen, SP1
Behrends, S; Harteneck, C; Koesling, D; Russwurm, M1
Gupte, SA; Phillibert, D; Rupawalla, T; Wolin, MS1
Babcock, GT; Brandish, PE; Di Valentin, M; DiValentin, M; Marletta, MA; Schelvis, JP; Zhao, Y1
Lee, YC; Martin, E; Murad, F1
Schmidt, P; Schramm, M; Schröder, H; Stasch, JP1
Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F1
Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S1
Hoffmann, LS; Keim, Y; Schaefer, S; Schmidt, HH; Schmidt, PM; Stasch, JP1
Badejo, AM; Bhartiya, M; Haider, U; Kadowitz, PJ; Murthy, SN; Nossaman, BD; Pankey, EA; Stasch, JP1
Hoffmann, C; Hoffmann, LS; Keim, Y; Schmidt, HH; Schmidt, PM; Stasch, JP1
Catucci, G; Di Nardo, G; Ferrero, VE; Gilardi, G; Sadeghi, SJ1
Akinfieva, OV; Artem'eva, MM; Daliger, IL; Medvedev, OS; Medvedeva, NA; Postnikov, AB; Shevelev, SA1
Branco, LG; Carvalho-Costa, PG; Leite-Panissi, CR1
Huang, ZX; Pan, J; Tan, X; Xu, Q; Yuan, H; Zhang, H; Zhang, X; Zhou, Y1
Krutsenko, Y; Lezgyieva, K; Martin, E; Sharina, I1
Dou, Z; Rees, KC; Whitehead, DC1

Other Studies

20 other study(ies) available for heme and oxadiazoles

ArticleYear
Effects of 3-(2-phenylethyl)-4-methylsydnone and related sydnones on heme biosynthesis.
    Biochemical pharmacology, 1990, Jun-01, Volume: 39, Issue:11

    Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ferrochelatase; Heme; Liver; Microsomes, Liver; Molecular Structure; Oxadiazoles; Porphyrins; Sydnones

1990
Cytochrome P-450 inactivation by 3-alkylsydnones. Mechanistic implications of N-alkyl and N-alkenyl heme adduct formation.
    Biochemistry, 1988, Jun-28, Volume: 27, Issue:13

    Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Indicators and Reagents; Kinetics; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; NADP; Oxadiazoles; Oxidation-Reduction; Protein Binding; Protoporphyrins; Rats; Rats, Inbred Strains; Sydnones

1988
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.
    Molecular pharmacology, 1996, Volume: 50, Issue:1

    Topics: Animals; Binding Sites; Cattle; Enzyme Inhibitors; Guanylate Cyclase; Heme; Kinetics; Lung; Nitric Oxide; Oxadiazoles; Quinoxalines; Spectrophotometry

1996
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.
    British journal of pharmacology, 1998, Volume: 123, Issue:2

    Topics: Animals; Cattle; Cells, Cultured; Cerebellum; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Heme; Humans; In Vitro Techniques; Kinetics; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Oxazines; Rabbits; Solubility; Spectrophotometry; Structure-Activity Relationship; Swine; Umbilical Veins

1998
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
    The Biochemical journal, 1998, Oct-01, Volume: 335 ( Pt 1)

    Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera

1998
NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; Cattle; Colforsin; Cyclic GMP; Electron Transport; Enzyme Activation; Enzyme Inhibitors; Ferricyanides; Flavoproteins; Glutathione; Guanylate Cyclase; Heme; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADP; Nitric Oxide; Oxadiazoles; Oxidation-Reduction; Penicillamine; Pentose Phosphate Pathway; Pulmonary Artery; Quinoxalines; Reactive Oxygen Species; Sulfhydryl Compounds

1999
Inhibition of soluble guanylate cyclase by ODQ.
    Biochemistry, 2000, Sep-05, Volume: 39, Issue:35

    Topics: Animals; Baculoviridae; Electron Spin Resonance Spectroscopy; Enzyme Activation; Enzyme Inhibitors; Ferric Compounds; Ferrous Compounds; Genetic Vectors; Guanylate Cyclase; Heme; Nitric Oxide; Oxadiazoles; Oxidation-Reduction; Peptide Fragments; Quinoxalines; Rats; Solubility; Spectrophotometry; Spectrum Analysis, Raman; Spodoptera

2000
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Nov-06, Volume: 98, Issue:23

    Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility

2001
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
    European journal of pharmacology, 2003, May-16, Volume: 468, Issue:3

    Topics: Benzoates; Diethylamines; Enzyme Activation; Guanylate Cyclase; Heme; Morpholines; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Pyrimidines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spectrophotometry, Ultraviolet

2003
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
    European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection

2005
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
    Biochemical and biophysical research communications, 2006, Feb-17, Volume: 340, Issue:3

    Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors

2006
Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
    British journal of pharmacology, 2009, Volume: 157, Issue:5

    Topics: Aequorin; Animals; Benzoates; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Enzyme Stability; Genes, Reporter; Guanylate Cyclase; Heme; Molecular Structure; Mutation; ortho-Aminobenzoates; Oxadiazoles; Oxidation-Reduction; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Structure-Activity Relationship; Sulfonamides; Swine; Transfection

2009
Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzoates; Biphenyl Compounds; Guanylate Cyclase; Heme; Hydrocarbons, Fluorinated; Hypertension, Pulmonary; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2011
Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Benzoates; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Cysteine; Enzyme Activation; Enzyme Activators; Fluorescence; Fluorescent Dyes; Guanylate Cyclase; Heme; Humans; Molecular Sequence Data; Mutation; Nitric Oxide; Oxadiazoles; Oxazines; Oxidation-Reduction; Protein Engineering; Receptors, Cytoplasmic and Nuclear; Rotenone; Signal Transduction; Soluble Guanylyl Cyclase; Spectrometry, Fluorescence

2011
Fluorescence detection of ligand binding to labeled cytochrome P450 BM3.
    Dalton transactions (Cambridge, England : 2003), 2012, Feb-21, Volume: 41, Issue:7

    Topics: Amides; Bacterial Proteins; Cytochrome P-450 Enzyme System; Fluorescent Dyes; Heme; Ligands; Models, Molecular; NADPH-Ferrihemoprotein Reductase; Oxadiazoles; Protein Binding; Protein Structure, Tertiary; Spectrometry, Fluorescence; Staining and Labeling

2012
[Peripheral mechanisms of action of oxatriazolium-5-olate derivative 3-(3-[1,2,4]-triazolo)oxatriazolium-5-olate in spontaneously hypertensive rats].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:8

    Topics: Animals; Arteries; Guanylate Cyclase; Heme; Male; Nitric Oxide; Nitroprusside; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Wistar; Tail; Tissue Culture Techniques; Triazoles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2012
Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2014, Volume: 47, Issue:12

    Topics: Acute Pain; Animals; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Lysine; Male; Nociceptive Pain; Oxadiazoles; Pain Measurement; Rats, Wistar; Signal Transduction; Stress Disorders, Traumatic, Acute

2014
The molecular mechanism of heme loss from oxidized soluble guanylate cyclase induced by conformational change.
    Biochimica et biophysica acta, 2016, Volume: 1864, Issue:5

    Topics: Fluorescence Resonance Energy Transfer; Guanylate Cyclase; Heme; Humans; Kinetics; Nitric Oxide; Oxadiazoles; Oxidation-Reduction; Protein Conformation; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2016
Higher susceptibility to heme oxidation and lower protein stability of the rare α
    Biochemical pharmacology, 2021, Volume: 186

    Topics: Animals; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Genetic Variation; Heme; Humans; Moyamoya Disease; Oxadiazoles; Oxazines; Oxidation-Reduction; Protein Stability; Protein Structure, Secondary; Sf9 Cells; Soluble Guanylyl Cyclase

2021
Oxadiazon Derivatives Elicit Potent Intracellular Growth Inhibition against
    ACS infectious diseases, 2022, 05-13, Volume: 8, Issue:5

    Topics: Heme; Humans; Oxadiazoles; Toxoplasma

2022