heme has been researched along with imidazole in 94 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (7.45) | 18.7374 |
| 1990's | 16 (17.02) | 18.2507 |
| 2000's | 43 (45.74) | 29.6817 |
| 2010's | 26 (27.66) | 24.3611 |
| 2020's | 2 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Ascenzi, P; Bolognesi, M; Frigerio, F; Guanziroli, MG; Lionetti, C | 1 |
| Scher, BM; Scher, W; Waxman, S | 1 |
| Jones, RL | 1 |
| Nunez, MT; Robinson, SH; Tsiftsoglou, AS; Wong, W | 1 |
| Barrick, D | 1 |
| Kulmacz, RJ; Palmer, G; Tsai, AL; Van Wart, HE; Wang, JS; Wang, Y | 1 |
| Magliozzo, RS; Peisach, J | 1 |
| Amada, F; Fukuyama, K; Kawamoto, M; Kunishima, N; Matsubara, H; Matsunaga, T | 1 |
| Yamamoto, Y | 1 |
| Berka, V; Chen, PF; Tsai, AL | 1 |
| Chan, CK; Eaton, WA; Hofrichter, J; Hu, Y; Rousseau, DL; Takahashi, S | 1 |
| Arvai, AS; Crane, BR; Gachhui, R; Getzoff, ED; Ghosh, DK; Stuehr, DJ; Tainer, JA; Wu, C | 1 |
| Babcock, GT; Marletta, MA; Schelvis, JP; Zhao, Y | 2 |
| Roder, H; Shastry, MC | 1 |
| Babcock, GT; Hoganson, C; Marletta, MA; Zhao, Y | 1 |
| Adachi, S; Hasnain, SS; Iizuka, T; Miyatake, H; Mukai, M; Nakamura, H; Shiro, Y; Strange, RW; Tamura, K | 1 |
| Dawson, JA; Hannis, JC; Lewis, JP; Macrina, FL; Muddiman, D | 1 |
| Dawson, JH; Lu, Y; Pond, AE; Sigman, JA | 1 |
| Ozaki, S; Roach, MP; Watanabe, Y | 1 |
| Feis, A; Howes, BD; Indiani, C; Marzocchi, MP; Smulevich, G | 1 |
| Arp, DJ; Meek, L | 1 |
| Berka, V; Tsai, AL | 1 |
| Aono, S; Ishikawa, H; Ishimori, K; Kitagawa, T; Mizutani, Y; Morishima, I; Nakajima, H; Uchida, T | 1 |
| Ferrari, RP; Ghibaudi, EM; Laurenti, E; Suriano, G | 1 |
| Blankenship, J; Goodin, DB; Hirst, J; McRee, DE; Wilcox, SK; Williams, PA | 1 |
| Ai, J; Goodin, DB; Hirst, J; Loehr, TM; Moënne-Loccoz, P; Wilcox, SK | 1 |
| Hori, H | 1 |
| Hirose, K; Iino, M; Namiki, S | 1 |
| Chirukhin, VA; Sharshina, LM; Zhernovoy, AI | 1 |
| Dawson, JH; Pond, AE; Roach, MP | 1 |
| Gorren, AC; Mayer, B; Schmidt, K | 1 |
| Kerby, RL; Roberts, GP; Youn, H | 2 |
| Hsu, PY; Wang, LH | 1 |
| KENDREW, JC; PARRIS, RG | 1 |
| KOTANI, M | 1 |
| BENZIMAN, M; GALANTER, Y | 1 |
| Chishiro, T; Liu, JG; Naruta, Y; Tachi, Y; Tani, F | 1 |
| Benson, DR; Cowley, AB; Lukat-Rodgers, GS; Rodgers, KR | 1 |
| Kitagawa, T; Li, Z; Ohta, T; Pal, B; Takenaka, S; Tsuyama, S | 1 |
| Barrick, D; Berezhna, S; Cao, W; Champion, PM; Christian, JF; Demidov, AA; Sage, JT; Sjodin, T; Wang, W; Ye, X | 1 |
| Falzone, CJ; Lecomte, JT; Nothnagel, HJ; Vu, BC; Vuletich, DA | 1 |
| Galstyan, AS; Knapp, EW; Zarić, SD | 1 |
| Komori, K; Takada, K; Tatsuma, T | 1 |
| de Visser, SP; Hirao, H; Kumar, D; Shaik, S; Sharma, PK | 1 |
| Franzen, S; Kruglik, SG; Lambry, JC; Martin, JL; Negrerie, M; Vos, MH | 1 |
| Fujii, H; Nakamura, H; Shiro, Y; Tanaka, A | 1 |
| Walker, FA | 1 |
| Burstyn, JN; Clark, RW; Pinkert, JC | 1 |
| Degtyarenko, I; Nieminen, RM; Rovira, C | 1 |
| Kitagawa, T; Ohta, T; Pal, B | 1 |
| Alian, A; de Montellano, PR; Verras, A | 1 |
| Burstyn, JN; Clark, RW; Lee, AJ; Roberts, GP; Youn, H | 1 |
| Hutzler, JM; Locuson, CW; Tracy, TS | 1 |
| Aono, S; Higuchi, Y; Inagaki, S; Komori, H; Yoshioka, S | 1 |
| Burstyn, JN; Cherney, MM; Frank, N; Kraus, JP; Marvin, KA; Pazicni, S | 1 |
| Dörr, S; Hellwig, P; Ortolani, M; Schade, U | 1 |
| Ibrahim, M; Spiro, TG; Xu, C | 1 |
| Mayer, JM; Warren, JJ | 1 |
| Catarino, T; Duke, NE; Londer, YY; Pessanha, M; Pokkuluri, PR; Salgueiro, CA; Schiffer, M; Wilton, R; Wood, SJ | 1 |
| Berry, EA; Walker, FA | 1 |
| Ferreira, GC; Hunter, GA; Sampson, MP | 1 |
| Collman, JP; Decréau, RA; Dey, A; Ghosh, S; Yang, Y | 1 |
| Berthomieu, C; Desbois, A; Marboutin, L | 1 |
| Frawley, ER; Kranz, RG | 1 |
| García-Rubio, I; Mitrikas, G | 1 |
| Makarov, SV; Silaghi-Dumitrescu, R | 1 |
| Kokhan, O; Shinkarev, VP; Wraight, CA | 2 |
| Bendall, DS; Howe, CJ; Rajagopal, BS; Wilson, MT; Worrall, JA | 1 |
| Astashkin, AV; Elmore, BO; Fan, W; Feng, C; Guillemette, JG | 1 |
| Bretsnyder, EC; Kranz, RG; Rodgers, KR; San Francisco, B | 1 |
| Dornevil, K; Geng, J; Liu, A | 1 |
| Atkins, WM; Bowman, MK; Conner, KP; Krzyaniak, MD; Vennam, P; Woods, CM | 1 |
| Acquaviva, R; Basile, L; Di Giacomo, C; Guccione, S; Modica, MN; Pappalardo, M; Pittalà, V; Salerno, L; Sorrenti, V | 1 |
| Hoshino, T; Kawaguchi, AT; Neya, S; Suzuki, M | 1 |
| Clubb, RT; Lei, B; Malmirchegini, GR; Ran, Y | 1 |
| Alp, EE; Hu, C; Hu, MY; Li, M; Oliver, AG; Pavlik, JW; Peng, Q; Sage, JT; Scheidt, WR; Zhao, J | 1 |
| Holden, JK; Jing, Q; Kang, S; Li, H; Poulos, TL; Richo, J; Silverman, RB | 1 |
| Adak, S; Bose, M; Roy, J; Saha, R; Sen Santara, S | 1 |
| Altruda, F; Chiabrando, D; Ingoglia, G; Mercurio, S; Silengo, L; Tolosano, E; Turco, E; Vinchi, F | 1 |
| Kranz, RG; San Francisco, B | 1 |
| Chiavarino, B; Coletti, C; Crestoni, ME; De Petris, A; Fornarini, S; Re, N | 1 |
| Ascenzi, P; Ciaccio, C; Coletta, M; de Sanctis, G; Polticelli, F; Zobnina, V | 1 |
| Hu, C; Scheidt, WR; Schulz, CE | 1 |
| Pletneva, EV; Zhong, F | 1 |
| Braun, A; Ehudin, MA; Gee, LB; Hedman, B; Hodgson, KO; Karlin, KD; Moënne-Loccoz, P; Sabuncu, S; Solomon, EI | 1 |
| Li, J; Ma, F; Peng, Q; Sun, CJ; Sun, HL; Wang, Z; Wu, Q; Xiao, H; Xu, W; Zhao, J | 1 |
| Ehudin, MA; Franke, A; Ivanović-Burmazović, I; Karlin, KD; Senft, L | 1 |
| Barreto, GA; Bernhardt, PV; Carepo, MSP; Diógenes, ICN; Gondim, ACS; Guimarães, WG; Lopes, LGF; Paulo, TF; Sousa, EHS | 1 |
| Shankar, R; Suresh, R; Vijayakumar, S | 1 |
| Fujihara, T; Hasegawa, JY; Saito, K; Takayanagi, T; Watabe, Y | 1 |
| Hasegawa, JY; Miyazaki, T; Saito, K; Takayanagi, T; Watabe, Y | 1 |
3 review(s) available for heme and imidazole
| Article | Year |
|---|---|
H93G myoglobin cavity mutant as versatile template for modeling heme proteins: magnetic circular dichroism studies of thiolate- and imidazole-ligated complexes.
Topics: Animals; Circular Dichroism; Cytochrome P-450 Enzyme System; Heme; Imidazoles; Iron; Ligands; Models, Molecular; Mutation; Myoglobin; Protein Binding | 2002 |
The heme environment of mouse neuroglobin: histidine imidazole plane orientations obtained from solution NMR and EPR spectroscopy as compared with X-ray crystallography.
Topics: Animals; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Globins; Heme; Hemeproteins; Histidine; Humans; Imidazoles; Mice; Models, Molecular; Nerve Tissue Proteins; Neuroglobin; Nuclear Magnetic Resonance, Biomolecular | 2006 |
Bis-histidine-coordinated hemes in four-helix bundles: how the geometry of the bundle controls the axial imidazole plane orientations in transmembrane cytochromes of mitochondrial complexes II and III and related proteins.
Topics: Cell Membrane; Cytochromes; Heme; Histidine; Imidazoles; Mitochondria | 2008 |
91 other study(ies) available for heme and imidazole
| Article | Year |
|---|---|
X-ray crystal structure of the ferric sperm whale myoglobin: imidazole complex at 2.0 A resolution.
Topics: Animals; Crystallography; Ferric Compounds; Heme; Imidazoles; Models, Molecular; Motion; Myoglobin; Protein Conformation; Whales; X-Ray Diffraction | 1991 |
A possible effect of heme on the fate of DNA ligase activity extracted from differentiating mouse erythroleukemia cells.
Topics: Acetamides; Adenosine Triphosphate; Animals; Cell Differentiation; Dimethyl Sulfoxide; DNA Ligases; Heme; Hemin; Imidazoles; Leukemia, Erythroblastic, Acute; Mice; Molecular Weight; Polynucleotide Ligases; Tumor Cells, Cultured | 1988 |
Hematin-derived anticoagulant. Generation in vitro and in vivo.
Topics: Anticoagulants; Blood Coagulation; Blood Coagulation Factors; Deferoxamine; Heme; Hemin; Imidazoles; In Vitro Techniques; Tin | 1986 |
Dissociation of iron transport and heme biosynthesis from commitment to terminal maturation of murine erythroleukemia cells.
Topics: Animals; Dimethyl Sulfoxide; Heme; Hemoglobins; Imidazoles; Iron; Kinetics; Leukemia, Experimental; Mice; Receptors, Cell Surface; Receptors, Transferrin; Transferrin | 1983 |
Replacement of the proximal ligand of sperm whale myoglobin with free imidazole in the mutant His-93-->Gly.
Topics: Animals; Crystallography, X-Ray; Escherichia coli; Glycine; Heme; Histidine; Imidazoles; Ligands; Mutagenesis, Site-Directed; Myoglobin; Protein Conformation; Spectrum Analysis; Whales | 1994 |
Heme coordination of prostaglandin H synthase.
Topics: Animals; Catalase; Circular Dichroism; Electron Spin Resonance Spectroscopy; Heme; Imidazoles; Ligands; Myoglobin; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Sheep; Spectrum Analysis, Raman | 1993 |
Evaluation of nitrogen nuclear hyperfine and quadrupole coupling parameters for the proximal imidazole in myoglobin-azide, -cyanide, and -mercaptoethanol complexes by electron spin echo envelope modulation spectroscopy.
Topics: Animals; Azides; Computer Simulation; Cyanides; Electron Spin Resonance Spectroscopy; Heme; Horses; Imidazoles; Magnetic Resonance Spectroscopy; Mercaptoethanol; Metmyoglobin; Myoglobin; Protein Binding; Protein Conformation | 1993 |
Pentacoordination of the heme iron of Arthromyces ramosus peroxidase shown by a 1.8 A resolution crystallographic study at pH 4.5.
Topics: Crystallography, X-Ray; Cytochrome-c Peroxidase; Heme; Histidine; Hydrogen-Ion Concentration; Imidazoles; Iron; Mitosporic Fungi; Models, Molecular; Peroxidase; Peroxidases; Protein Conformation; Spectrophotometry; Water | 1996 |
H-NMR study of temperature-induced structure alteration at the active site of horse heart cytochrome c.
Topics: Animals; Binding Sites; Cytochrome c Group; Heme; Histidine; Horses; Imidazoles; Magnetic Resonance Spectroscopy; Models, Molecular; Myocardium; Protons; Temperature | 1996 |
Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthase.
Topics: Arginine; Binding Sites; Binding, Competitive; Cyanides; Endothelium, Vascular; Heme; Humans; Imidazoles; Kinetics; Lysine; Nitric Oxide Synthase | 1996 |
Submillisecond protein folding kinetics studied by ultrarapid mixing.
Topics: Animals; Cytochrome c Group; Fluorescence; Guanidine; Guanidines; Heme; Horses; Imidazoles; Kinetics; Myocardium; Protein Denaturation; Protein Folding; Tryptophan | 1997 |
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Biopterins; Caenorhabditis elegans Proteins; Catalysis; Crystallography, X-Ray; Dimerization; Enzyme Induction; Enzyme Inhibitors; Guanidines; Heme; Homeodomain Proteins; Hydrogen Bonding; Imidazoles; Isoenzymes; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Protein Folding; Protein Structure, Secondary | 1997 |
Identification of histidine 105 in the beta1 subunit of soluble guanylate cyclase as the heme proximal ligand.
Topics: Alanine; Escherichia coli; Guanylate Cyclase; Heme; Histidine; Imidazoles; Ligands; Mutagenesis, Site-Directed; Solubility; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 1998 |
Evidence for barrier-limited protein folding kinetics on the microsecond time scale.
Topics: Animals; Cytochrome c Group; Energy Metabolism; Heme; Horses; Imidazoles; Kinetics; Ligands; Models, Molecular; Protein Folding; Spectrometry, Fluorescence; Temperature | 1998 |
Structural changes in the heme proximal pocket induced by nitric oxide binding to soluble guanylate cyclase.
Topics: Animals; Binding Sites; Electron Spin Resonance Spectroscopy; Guanylate Cyclase; Heme; Imidazoles; Macromolecular Substances; Nitric Oxide; Peptide Fragments; Rats; Solubility | 1998 |
Resonance raman characterization of the heme domain of soluble guanylate cyclase.
Topics: Animals; Carbon Monoxide; Ferrous Compounds; Glycine; Guanylate Cyclase; Heme; Histidine; Imidazoles; Lung; Nitric Oxide; Peptide Fragments; Protein Structure, Tertiary; Rats; Solubility; Spectrum Analysis, Raman | 1998 |
Iron coordination structures of oxygen sensor FixL characterized by Fe K-edge extended x-ray absorption fine structure and resonance raman spectroscopy.
Topics: Bacterial Proteins; Fluorides; Heme; Hemeproteins; Histidine; Histidine Kinase; Imidazoles; Iron; Ligands; Oxygen; Protein Kinases; Spectrum Analysis; Spectrum Analysis, Raman; X-Rays | 1999 |
Hemoglobinase activity of the lysine gingipain protease (Kgp) of Porphyromonas gingivalis W83.
Topics: Adhesins, Bacterial; Agar; Amino Acid Sequence; Blood; Chromatography; Chromosome Mapping; Cysteine Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Gingipain Cysteine Endopeptidases; Helminth Proteins; Hemagglutinins; Heme; Hemin; Hemoglobins; Hemolysis; Humans; Imidazoles; Iron; Mass Spectrometry; Membrane Proteins; Molecular Sequence Data; Mutagenesis; Peptide Fragments; Porphyromonas gingivalis | 1999 |
Engineering cytochrome c peroxidase into cytochrome P450: a proximal effect on heme-thiolate ligation.
Topics: Aspartic Acid; Circular Dichroism; Cysteine; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome-c Peroxidase; Cytochromes c; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferric Compounds; Heme; Histidine; Imidazoles; Leucine; Ligands; Mutagenesis, Site-Directed; Protein Engineering; Spectrophotometry, Ultraviolet | 1999 |
Investigations of the myoglobin cavity mutant H93G with unnatural imidazole proximal ligands as a modular peroxide O-O bond cleavage model system.
Topics: Animals; Glycine; Heme; Histidine; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Imidazoles; Iron; Ligands; Models, Chemical; Mutagenesis, Site-Directed; Myoglobin; Oxygen; Sodium Nitrite; Whales | 2000 |
Effect of low temperature on soybean peroxidase: spectroscopic characterization of the quantum-mechanically admixed spin state.
Topics: Binding Sites; Electron Spin Resonance Spectroscopy; Freezing; Glycine max; Heme; Imidazoles; Peroxidases; Porphyrins; Protein Conformation; Quantum Theory; Recombinant Proteins; Spectrophotometry; Spectrum Analysis, Raman; Thermodynamics | 2000 |
The hydrogenase cytochrome b heme ligands of Azotobacter vinelandii are required for full H(2) oxidation capability.
Topics: Amino Acid Sequence; Amino Acid Substitution; Azotobacter vinelandii; Cytochrome b Group; Dimerization; Heme; Histidine; Hydrogen; Hydrogenase; Imidazoles; Ligands; Methylene Blue; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Plasmids | 2000 |
Characterization of interactions among the heme center, tetrahydrobiopterin, and L-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes.
Topics: Animals; Arginine; Binding, Competitive; Biopterins; Catalysis; Cattle; Computer Simulation; Cyanides; Escherichia coli; Ferric Compounds; Flavins; Genetic Vectors; Heme; Humans; Imidazoles; Ligands; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding | 2000 |
Identification of histidine 77 as the axial heme ligand of carbonmonoxy CooA by picosecond time-resolved resonance Raman spectroscopy.
Topics: Bacterial Proteins; Carbon Monoxide; Escherichia coli; Escherichia coli Proteins; Fimbriae Proteins; Heme; Histidine; Imidazoles; Iron; Ligands; Mutagenesis, Site-Directed; Myoglobin; Photolysis; Spectrum Analysis, Raman; Tyrosine | 2000 |
Ionic strength and pH effect on the Fe(III)-imidazolate bond in the heme pocket of horseradish peroxidase: an EPR and UV-visible combined approach.
Topics: Chlorides; Electron Spin Resonance Spectroscopy; Heme; Horseradish Peroxidase; Hydrogen-Ion Concentration; Imidazoles; Iron; Osmolar Concentration; Protein Conformation; Spectrophotometry, Ultraviolet | 2000 |
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Topics: Amino Acid Substitution; Binding Sites; Computer Simulation; Crystallography, X-Ray; Cytochrome-c Peroxidase; Escherichia coli; Glycine; Heme; Histidine; Hydrogen-Ion Concentration; Imidazoles; Ligands; Models, Molecular; Phosphates; Protein Binding; Protein Conformation; Structure-Activity Relationship; Temperature | 2001 |
Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 2. Effects on heme coordination and function.
Topics: Amino Acid Substitution; Binding Sites; Cytochrome-c Peroxidase; Electron Spin Resonance Spectroscopy; Escherichia coli; Ferrous Compounds; Free Radicals; Glycine; Heme; Histidine; Imidazoles; Ligands; Nitric Oxide; Protein Binding; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 2001 |
Analysis of the principal g-tensors in single crystals of ferrimyoglobin complexes.
Topics: Animals; Electron Spin Resonance Spectroscopy; Heme; Histidine; Imidazoles; Metmyoglobin; Models, Molecular; Muscle, Skeletal; Potassium Cyanide; Sodium Azide; Thiocyanates; Whales | 1971 |
Mapping of heme-binding domains in soluble guanylyl cyclase beta1 subunit.
Topics: Animals; Binding Sites; Brain; Dithionite; Guanylate Cyclase; Heme; Imidazoles; Nitric Oxide; Protein Binding; Protein Interaction Mapping; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Sequence Deletion; Soluble Guanylyl Cyclase; Spectrum Analysis; Thioredoxins | 2001 |
In vivo hemoglobin allotropy in magnetic field.
Topics: Animals; Dogs; Heme; Hemoglobins; Hydrogen-Ion Concentration; Imidazoles; Magnetic Resonance Spectroscopy; Magnetics; Myoglobin; Oxygen; Oxyhemoglobins; Pressure | 2001 |
Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase.
Topics: Animals; Arginine; Binding, Competitive; Biopterins; Cell Line; Heme; Humans; Imidazoles; Kinetics; Mice; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Spectrophotometry, Ultraviolet; Spodoptera; Titrimetry; Tumor Cells, Cultured | 2002 |
The role of the hydrophobic distal heme pocket of CooA in ligand sensing and response.
Topics: Bacterial Proteins; Cyanides; Dose-Response Relationship, Drug; Heme; Hemeproteins; Imidazoles; Isoleucine; Leucine; Ligands; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Rhodospirillum rubrum; Trans-Activators; Transcriptional Activation | 2003 |
Protein engineering of thromboxane synthase: conversion of membrane-bound to soluble form.
Topics: Amino Acid Sequence; Gene Expression; Heme; Humans; Imidazoles; Intracellular Membranes; Molecular Sequence Data; Mutagenesis, Site-Directed; Prostaglandin Endoperoxides, Synthetic; Protein Engineering; Recombinant Proteins; Solubility; Thromboxane-A Synthase | 2003 |
Imidazole complexes of myoglobin and the position of the haem group.
Topics: Heme; Hemoglobins; Humans; Imidazoles; Myoglobin | 1955 |
NOTE ON THE ELECTRONIC INTERACTION BETWEEN IMIDAZOLE AND IRON IN HEME.
Topics: Azides; Chemical Phenomena; Chemistry, Physical; Electrons; Fluorides; Heme; Imidazoles; Iron; Myoglobin | 1964 |
FLAVINE ADENINE DINUCLEOTIDE-LINKED MALIC DEHYDROGENASE FROM ACETOBACTER XYLINUM.
Topics: Acetobacter; Adenine; Amobarbital; Enzyme Inhibitors; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Gluconacetobacter xylinus; Heme; Imidazoles; Iron; Israel; Malate Dehydrogenase; Malates; Pharmacology; Phenanthrolines; Phenazines; Phenols; Quinacrine; Quinolines; Research; Riboflavin | 1964 |
Formation and spectroscopic characterization of the dioxygen adduct of a heme-Cu complex possessing a cross-linked tyrosine-histidine mimic: modeling the active site of cytochrome c oxidase.
Topics: Binding Sites; Copper; Electron Transport Complex IV; Heme; Histidine; Imidazoles; Molecular Mimicry; Molecular Structure; Oxygen; Phenols; Porphyrins; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Tyrosine | 2004 |
A possible role for the covalent heme-protein linkage in cytochrome c revealed via comparison of N-acetylmicroperoxidase-8 and a synthetic, monohistidine-coordinated heme peptide.
Topics: Animals; Binding Sites; Cytochromes c; Electron Spin Resonance Spectroscopy; Enzyme Stability; Ferric Compounds; Glycine; Heme; Hemeproteins; Histidine; Horses; Imidazoles; Iron; Ligands; Mercaptoethanol; Methionine; Peptide Fragments; Peptides; Protein Structure, Secondary; Spectrum Analysis, Raman; Structure-Activity Relationship | 2004 |
Resonance Raman study on synergistic activation of soluble guanylate cyclase by imidazole, YC-1 and GTP.
Topics: Animals; Cattle; Drug Synergism; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Heme; Imidazoles; In Vitro Techniques; Indazoles; Solubility; Spectrum Analysis, Raman | 2004 |
Investigations of photolysis and rebinding kinetics in myoglobin using proximal ligand replacements.
Topics: Amino Acid Substitution; Animals; Bromine; Carbon Monoxide; Glycine; Heme; Histidine; Imidazoles; Kinetics; Ligands; Models, Chemical; Myoglobin; Photolysis; Protein Binding; Pyridines; Spectrophotometry; Spectrum Analysis, Raman; Whales | 2004 |
Changing the ligand specificity of CooA, a highly specific heme-based CO sensor.
Topics: Carbon Monoxide; DNA; Escherichia coli Proteins; Fimbriae Proteins; Heme; Imidazoles; Ligands | 2004 |
Cyanide binding to hexacoordinate cyanobacterial hemoglobins: hydrogen-bonding network and heme pocket rearrangement in ferric H117A Synechocystis hemoglobin.
Topics: Alanine; Bacterial Proteins; Binding Sites; Cyanobacteria; Heme; Hemeproteins; Hemoglobins; Histidine; Hot Temperature; Hydrogen Bonding; Imidazoles; Iron; Mutagenesis, Site-Directed; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Potassium Cyanide; Protein Binding; Protein Denaturation; Recombinant Proteins; Truncated Hemoglobins | 2004 |
Computational studies on imidazole heme conformations.
Topics: Heme; Imidazoles; Models, Molecular; Proteins; Solubility; Static Electricity; Thermodynamics; Water | 2005 |
Toward selectivity control of a heme peptide electrode by modification with a phase-transition polymer.
Topics: Acrylic Resins; Catalysis; Electrochemistry; Electrodes; Heme; Histamine; Hydrogen Peroxide; Imidazoles; Indicators and Reagents; Oxidants; Peptides; Polymers; Temperature | 2005 |
Sulfoxidation mechanisms catalyzed by cytochrome P450 and horseradish peroxidase models: spin selection induced by the ligand.
Topics: Armoracia; Bacterial Proteins; Catalysis; Computational Biology; Cytochrome P-450 Enzyme System; Electron Transport; Ferric Compounds; Heme; Horseradish Peroxidase; Imidazoles; Ligands; Models, Chemical; Plant Proteins; Pseudomonas putida; Substrate Specificity; Sulfhydryl Compounds; Sulfides; Thermodynamics | 2005 |
Role of heme iron coordination and protein structure in the dynamics and geminate rebinding of nitric oxide to the H93G myoglobin mutant: implications for nitric oxide sensors.
Topics: Animals; Cattle; Heme; Humans; Imidazoles; Iron; Kinetics; Ligands; Models, Chemical; Models, Molecular; Mutation; Myoglobin; Nitric Oxide; Nitrogen; Protein Binding; Protein Conformation; Proteins; Spectrophotometry; Spectrum Analysis, Raman; Time Factors | 2006 |
Roles of the heme distal residues of FixL in O2 sensing: a single convergent structure of the heme moiety is relevant to the downregulation of kinase activity.
Topics: Arginine; Bacterial Proteins; Binding Sites; Cyanides; Down-Regulation; Heme; Hemeproteins; Histidine Kinase; Hydrogen Bonding; Imidazoles; Iron; Isoleucine; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Mutation; Oxidation-Reduction; Oxygen; Phosphorylation; Protein Conformation; Protein Kinases; Sinorhizobium meliloti; Spectrum Analysis, Raman | 2006 |
Modeling proline ligation in the heme-dependent CO sensor, CooA, using small-molecule analogs.
Topics: Bacterial Proteins; Carbon Monoxide; Computational Biology; Crystallography, X-Ray; Heme; Hemeproteins; Histidine; Imidazoles; Iron; Ligands; Models, Molecular; Molecular Structure; Proline; Pyrrolidines; Trans-Activators | 2006 |
Structure and dynamics of dioxygen bound to cobalt and iron heme.
Topics: Binding Sites; Cobalt; Computer Simulation; Ferric Compounds; Heme; Histidine; Imidazoles; Iron; Models, Molecular; Myoglobin; Oxides; Oxygen; Porphyrins; Protein Conformation | 2006 |
Excited state property of hardly photodissociable heme-CO adduct studied by time-dependent density functional theory.
Topics: Carbon Monoxide; Electrons; Heme; Imidazoles; Iron; Ligands; Models, Molecular; Photolysis; Spectrum Analysis, Raman; Water | 2005 |
Cytochrome P450 active site plasticity: attenuation of imidazole binding in cytochrome P450(cam) by an L244A mutation.
Topics: Amino Acid Substitution; Camphor 5-Monooxygenase; Catalytic Domain; Crystallography, X-Ray; Heme; Imidazoles; Iron; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Engineering; Recombinant Proteins; Substrate Specificity | 2006 |
DNA binding by an imidazole-sensing CooA variant is dependent on the heme redox state.
Topics: Bacterial Proteins; Carbon Monoxide; Circular Dichroism; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Heme; Hemeproteins; Histidine; Imidazoles; Oxidation-Reduction; Rhodospirillum rubrum; Trans-Activators | 2007 |
Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common.
Topics: Aniline Compounds; Aryl Hydrocarbon Hydroxylases; Benzodioxoles; Binding Sites; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Heme; Humans; Imidazoles; Itraconazole; Kinetics; Ligands; Light; Models, Chemical; Molecular Structure; NADP; Nonlinear Dynamics; Protein Binding; Pyrimidines; Recombinant Proteins; Reference Standards; Regression Analysis; Spectrum Analysis; Sulfaphenazole; Triazoles | 2007 |
Crystal structure of CO-sensing transcription activator CooA bound to exogenous ligand imidazole.
Topics: Bacterial Proteins; Carbon Monoxide; Crystallography, X-Ray; Heme; Imidazoles; Ligands; Models, Molecular; Peptococcaceae; Protein Conformation; Protein Structure, Quaternary; Trans-Activators | 2007 |
Ferrous human cystathionine beta-synthase loses activity during enzyme assay due to a ligand switch process.
Topics: Allosteric Regulation; Cystathionine beta-Synthase; Enzyme Stability; Ferrous Compounds; Heme; Humans; Imidazoles; Kinetics; Ligands; Oxidation-Reduction; Spectrophotometry | 2007 |
Characterization of temperature-dependent iron-imidazole vibrational modes in far infrared.
Topics: Biomimetic Materials; Heme; Hydrogen Bonding; Imidazoles; Iron; Isotope Labeling; Ligands; Metalloproteins; Micelles; Protoporphyrins; Sodium Dodecyl Sulfate; Spectrophotometry, Infrared; Surface-Active Agents; Temperature | 2007 |
DFT analysis of axial and equatorial effects on heme-CO vibrational modes: applications to CooA and H-NOX heme sensor proteins.
Topics: Bacterial Proteins; Biosensing Techniques; Carbon; Carbon Dioxide; Heme; Histidine; Hydrogen Bonding; Imidazoles; Models, Biological; Models, Molecular; Molecular Conformation; Nitric Oxide; Oxides; Oxygen; Porphyrins; Propionates; Protein Folding; Quantum Theory; Thermoanaerobacter; Vibration | 2008 |
Hydrogen atom transfer reactions of iron-porphyrin-imidazole complexes as models for histidine-ligated heme reactivity.
Topics: Heme; Histidine; Hydrogen; Imidazoles; Iron; Kinetics; Ligands; Models, Chemical; Molecular Structure; Porphyrins | 2008 |
Structures and solution properties of two novel periplasmic sensor domains with c-type heme from chemotaxis proteins of Geobacter sulfurreducens: implications for signal transduction.
Topics: Bacterial Proteins; Carbon Monoxide; Chemotaxis; Chromatography, Gel; Circular Dichroism; Crystallography, X-Ray; Dimerization; Electron Spin Resonance Spectroscopy; Geobacter; Heme; Hydrogen-Ion Concentration; Imidazoles; Magnetic Resonance Spectroscopy; Nitric Oxide; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Signal Transduction | 2008 |
Metal ion substrate inhibition of ferrochelatase.
Topics: Animals; Catalysis; Cations, Divalent; Ferrochelatase; Heme; Humans; Hydrogen-Ion Concentration; Imidazoles; Mercaptoethanol; Metals, Heavy; Mice; Oxidation-Reduction; Protoporphyrins; Recombinant Proteins; Saccharomyces cerevisiae; Substrate Specificity | 2008 |
Catalytic reduction of O2 by cytochrome C using a synthetic model of cytochrome C oxidase.
Topics: Animals; Biomimetics; Catalysis; Catalytic Domain; Copper; Cytochromes c; Electron Transport; Electron Transport Complex IV; Ferric Compounds; Heme; Horses; Imidazoles; Kinetics; Oxidation-Reduction; Oxygen; Water | 2009 |
Low-frequency heme, iron-ligand, and ligand modes of imidazole and imidazolate complexes of iron protoporphyrin and microperoxidase in aqueous solution. An analysis by far-infrared difference spectroscopy.
Topics: Heme; Imidazoles; Iron; Ligands; Molecular Structure; Peptides; Peroxidases; Protoporphyrins; Solutions; Spectroscopy, Fourier Transform Infrared | 2009 |
CcsBA is a cytochrome c synthetase that also functions in heme transport.
Topics: Amino Acid Sequence; Bacteria; Cell Membrane; Conserved Sequence; Core Binding Factors; Escherichia coli; Heme; Histidine; Imidazoles; Ligands; Lyases; Membrane Proteins; Mutation; Phylogeny; Protein Structure, Tertiary; Recombinant Proteins | 2009 |
Structure and spin density of ferric low-spin heme complexes determined with high-resolution ESEEM experiments at 35 GHz.
Topics: Electron Spin Resonance Spectroscopy; Ferric Compounds; Heme; Imidazoles; Nitrogen | 2010 |
A computational analysis of electromerism in hemoprotein Fe(I) models.
Topics: Electrons; Heme; Hemeproteins; Imidazoles; Iron; Models, Molecular; Protein Conformation; Quantum Theory; Thermodynamics | 2010 |
Binding of imidazole to the heme of cytochrome c1 and inhibition of the bc1 complex from Rhodobacter sphaeroides: I. Equilibrium and modeling studies.
Topics: Cytochromes c1; Electron Transport Complex III; Heme; Imidazoles; Kinetics; Ligands; Models, Molecular; Molecular Dynamics Simulation; Oxidation-Reduction; Rhodobacter sphaeroides; Spectrum Analysis; Temperature | 2010 |
Binding of imidazole to the heme of cytochrome c1 and inhibition of the bc1 complex from Rhodobacter sphaeroides: II. Kinetics and mechanism of binding.
Topics: Cytochromes c1; Electron Transport Complex III; Enzyme Activation; Heme; Imidazoles; Kinetics; Ligands; Oxidation-Reduction; Rhodobacter sphaeroides; Temperature | 2010 |
Structural and kinetic studies of imidazole binding to two members of the cytochrome c (6) family reveal an important role for a conserved heme pocket residue.
Topics: Arabidopsis; Binding Sites; Crystallography, X-Ray; Cyanobacteria; Cytochromes c6; Heme; Imidazoles; Kinetics; Models, Molecular; Molecular Structure | 2011 |
Pulsed ENDOR determination of relative orientation of g-frame and molecular frame of imidazole-coordinated heme center of iNOS.
Topics: Electron Spin Resonance Spectroscopy; Heme; Humans; Imidazoles; Models, Molecular; Nitric Oxide Synthase Type II | 2011 |
Heme ligand identification and redox properties of the cytochrome c synthetase, CcmF.
Topics: Amino Acid Substitution; Binding Sites; Biocatalysis; Enzyme Activation; Escherichia coli Proteins; Heme; Histidine; Holoenzymes; Imidazoles; Indicators and Reagents; Ligands; Lyases; Models, Molecular; Mutant Proteins; Oxidation-Reduction; Phylogeny; Protein Conformation; Protein Subunits; Recombinant Proteins; Spectrum Analysis, Raman | 2011 |
Chemical rescue of the distal histidine mutants of tryptophan 2,3-dioxygenase.
Topics: Binding Sites; Catalytic Domain; Cupriavidus; Heme; Histidine; Imidazoles; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Substrate Specificity; Tryptophan Oxygenase | 2012 |
1,2,3-Triazole-heme interactions in cytochrome P450: functionally competent triazole-water-heme complexes.
Topics: Click Chemistry; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Ethinyl Estradiol; Heme; Imidazoles; Isomerism; Kinetics; Magnetic Resonance Spectroscopy; Protein Binding; Quantum Theory; Thermodynamics; Triazoles; Water | 2012 |
Evaluation of imidazole-based compounds as heme oxygenase-1 inhibitors.
Topics: Animals; Binding Sites; Enzyme Inhibitors; Heme; Heme Oxygenase-1; Humans; Imidazoles; Molecular Docking Simulation; Phenyl Ethers; Protein Binding; Protein Structure, Tertiary; Rats; Recombinant Proteins | 2012 |
Relaxation analysis of ligand binding to the myoglobin reconstituted with cobaltic heme.
Topics: Animals; Binding Sites; Cobalt; Cyanides; Heme; Imidazoles; Ligands; Myoglobin; Oxidation-Reduction; Protein Binding; Pyridines; Whales | 2013 |
Axial ligand replacement mechanism in heme transfer from streptococcal heme-binding protein Shp to HtsA of the HtsABC transporter.
Topics: ATP-Binding Cassette Transporters; Carrier Proteins; Circular Dichroism; Heme; Heme-Binding Proteins; Hemeproteins; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Ligands; Streptococcus pyogenes | 2013 |
Probing heme vibrational anisotropy: an imidazole orientation effect?
Topics: Anisotropy; Coordination Complexes; Heme; Imidazoles; Iron; Quantum Theory; Vibration | 2013 |
Structural and biological studies on bacterial nitric oxide synthase inhibitors.
Topics: Animals; Anti-Bacterial Agents; Bacillus subtilis; Catalytic Domain; Cloning, Molecular; Crystallization; Heme; Imidazoles; Models, Molecular; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Oxidative Stress; Protein Binding; Rats; Regression Analysis | 2013 |
Identification of proximal and distal axial ligands in Leishmania major pseudoperoxidase.
Topics: Amino Acid Substitution; Carbon Monoxide; Electron Spin Resonance Spectroscopy; Heme; Hydrogen-Ion Concentration; Imidazoles; Leishmania major; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Peroxidase; Protein Binding; Protozoan Proteins; Structural Homology, Protein | 2013 |
Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450.
Topics: Animals; Benzo(a)pyrene; Cation Transport Proteins; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Ferritins; Heme; Heme Oxygenase-1; Hemolysis; Hepatocytes; Homeostasis; Imidazoles; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Knockout; Phenylhydrazines; Receptors, Virus; RNA, Messenger | 2014 |
Interaction of holoCcmE with CcmF in heme trafficking and cytochrome c biosynthesis.
Topics: Amino Acid Sequence; Bacterial Outer Membrane Proteins; Cytochromes c; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Heme; Hemeproteins; Holoenzymes; Imidazoles; Molecular Sequence Data; Plasmids; Protein Transport; Spectrophotometry, Ultraviolet | 2014 |
Exploring the conformational variability in the heme b propionic acid side chains through the effect of a biological probe: a study of the isolated ions.
Topics: Ferric Compounds; Heme; Imidazoles; Ions; Propionates; Spectrophotometry, Infrared; Sterol 14-Demethylase; Thermodynamics | 2015 |
Enhanced heme accessibility in horse heart mini-myoglobin: Insights from molecular modelling and reactivity studies.
Topics: Animals; Azides; Heme; Horses; Imidazoles; Iron; Kinetics; Ligands; Molecular Dynamics Simulation; Myocardium; Myoglobin; Peptide Fragments; Protein Structure, Secondary; Recombinant Proteins; Thermodynamics | 2015 |
All high-spin (S = 2) iron(ii) hemes are NOT alike.
Topics: Anions; Circular Dichroism; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Ferrous Compounds; Heme; Hydrogen Bonding; Imidazoles; Ligands; Quantum Theory; Spectroscopy, Mossbauer | 2015 |
Ligation and Reactivity of Methionine-Oxidized Cytochrome c.
Topics: Amino Acid Sequence; Binding Sites; Cytochromes c; Electron Spin Resonance Spectroscopy; Heme; Imidazoles; Iron; Ligands; Methionine; Models, Biological; Oxidation-Reduction; Spectrum Analysis, Raman; Sulfoxides; Yeasts | 2018 |
Tuning the Geometric and Electronic Structure of Synthetic High-Valent Heme Iron(IV)-Oxo Models in the Presence of a Lewis Acid and Various Axial Ligands.
Topics: Electrons; Heme; Imidazoles; Iron; Lewis Acids; Ligands; Models, Molecular; Molecular Conformation | 2019 |
Proton mediated spin state transition of cobalt heme analogs.
Topics: Biocatalysis; Cobalt; Crystallography, X-Ray; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Histidine; Hydrogen-Ion Concentration; Imidazoles; Iron; Ligands; Oxidation-Reduction; Protons | 2019 |
Formation and Reactivity of New Isoporphyrins: Implications for Understanding the Tyr-His Cross-Link Cofactor Biogenesis in Cytochrome
Topics: Animals; Catalytic Domain; Cattle; Electron Transport Complex IV; Ferric Compounds; Heme; Imidazoles; Models, Molecular; Porphyrins | 2019 |
A spectroelectrochemical investigation of the heme-based sensor DevS from Mycobacterium tuberculosis: a redox versus oxygen sensor.
Topics: Bacterial Proteins; Biosensing Techniques; Carbon Monoxide; Cyanides; Heme; Humans; Imidazoles; Mycobacterium tuberculosis; Nitric Oxide; Oxidation-Reduction; Oxygen; Protamine Kinase; Tuberculosis | 2019 |
Ab initio studies of adsorption of Haloarenes on Heme group.
Topics: Adsorption; Animals; Bromine; Chlorine; Electrons; Fluorine; Gases; Heme; Humans; Imidazoles; Iodine; Ions; Iron; Models, Molecular; Oxidation-Reduction; Oxygen; Thermodynamics | 2019 |
Spin-inversion mechanisms in O
Topics: Density Functional Theory; Heme; Imidazoles; Iron; Models, Molecular; Molecular Dynamics Simulation; Oxygen; Protein Binding; Structure-Activity Relationship; Thermodynamics | 2020 |
Spin-inversion mechanisms in O
Topics: Density Functional Theory; Heme; Imidazoles; Iron; Models, Molecular; Molecular Conformation; Oxygen | 2020 |