heme has been researched along with gemfibrozil in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Allen, A; Baer, BR; DeLisle, RK | 1 |
| Gambaryan, S; Martin, E; Papakyriakou, A; Rukoyatkina, N; Sharina, IG; Sobolevsky, M; Spyroulias, GA | 1 |
| Shah, MB | 1 |
1 review(s) available for heme and gemfibrozil
| Article | Year |
|---|---|
Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges.
Topics: Cholesterol; Clopidogrel; Cytochrome P-450 CYP2C8; Gemfibrozil; Glucuronides; Heme; Platelet Aggregation Inhibitors; Triglycerides | 2022 |
2 other study(ies) available for heme and gemfibrozil
| Article | Year |
|---|---|
Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition.
Topics: Alkylation; Aryl Hydrocarbon Hydroxylases; Catalytic Domain; Chromatography, High Pressure Liquid; Computer Simulation; Cytochrome P-450 CYP2C8; Gemfibrozil; Glucuronates; Heme; Humans; Hypolipidemic Agents; Mass Spectrometry; Oxidation-Reduction; Recombinant Proteins | 2009 |
The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.
Topics: Animals; Aorta, Thoracic; Binding Sites; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Gemfibrozil; Guanylate Cyclase; Heme; Humans; Hypolipidemic Agents; Male; Molecular Docking Simulation; Nitric Oxide; Oxidation-Reduction; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Structure, Tertiary; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Signal Transduction; Soluble Guanylyl Cyclase; Time Factors; Vasodilation; Vasodilator Agents | 2015 |