heme has been researched along with deferoxamine in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (44.19) | 18.7374 |
| 1990's | 23 (26.74) | 18.2507 |
| 2000's | 18 (20.93) | 29.6817 |
| 2010's | 4 (4.65) | 24.3611 |
| 2020's | 3 (3.49) | 2.80 |
| Authors | Studies |
|---|---|
| Jacobs, A | 1 |
| Löhr, GW | 1 |
| Liem, H; Muller-Eberhard, U; Smith, A | 1 |
| Hoy, T; Humphrys, J; Jacobs, A; Ponka, P; Williams, A | 1 |
| Anderson, KE | 1 |
| Granick, S; Sinclair, PR | 1 |
| Chin, J; Haile, DJ; Harford, JB; Klausner, RD; Rouault, TA; Tang, CK | 1 |
| Hebbel, RP; Repka, T | 1 |
| Leclerc, L; Marden, M; Poyart, C | 1 |
| Alcedo, JA; Bement, WJ; Hamilton, JW; Sinclair, JF; Sinclair, PR; Wetterhahn, KE | 1 |
| Eisenstein, RS; Garcia-Mayol, D; Munro, HN; Pettingell, W | 1 |
| Eisenstein, RS; Munro, HN | 1 |
| Haile, DJ; Harford, JB; Klausner, RD; Rouault, TA | 1 |
| Kupfer, B; Moroz, C; Shterman, N | 1 |
| Bottomley, SS; Bridges, KR; Wolfe, LC | 1 |
| Harford, J; Klausner, RD; Mattia, E; Rao, K; Rouault, T | 1 |
| Barbieri, R; Castagnoli, A; Del Senno, L; Gambari, R; Piva, R; Viola, L | 1 |
| Arfors, KE; Carlin, G; Djursäter, R | 1 |
| Barbieri, R; Feriotto, G; Gambari, R; Nastruzzi, C | 1 |
| DeFalco, MG; Giffhorn-Katz, S; Grasso, JA; Katz, NR; Liem, HH; Muller-Eberhard, U | 1 |
| Bonkovsky, HL; Healey, JF; Robinson, JM; Shedlofsky, SI; Sinclair, PR; Swim, AT | 1 |
| Munro, H; Rogers, J | 1 |
| Barbieri, R; Feriotto, G; Gambari, R; Nastruzzi, C; Traniello, F | 1 |
| Althaus, B; Linder, MC; Mulligan, M | 1 |
| Jones, RL | 1 |
| Bonkovsky, HL; Healey, JF; Sinclair, JF; Sinclair, PR | 1 |
| Barnes, R; Connelly, JL; Jones, OT | 1 |
| Ricci-bitti, ML; Tura, S | 1 |
| Hedenberg, L | 1 |
| Gerlanc, MD; Princiotto, JV; Rubin, M; Zapolski, EJ | 1 |
| Mainzer, K | 1 |
| Huser, HJ; Rafal, S; Weinstein, MB; Weintraub, LR | 1 |
| Knüsel, F; Nüesch, J | 1 |
| Kitchin, KT | 1 |
| Pollack, S | 1 |
| Gambari, R | 1 |
| Barbieri, R; Bernardi, F; Buzzoni, D; Conconi, F; Del Senno, L; Gambari, R; Marchetti, G; Perrotta, CM; Piva, MR | 1 |
| Fantoni, A; Farace, MG; Gambari, R; Raschellà, G; Tripodi, M | 1 |
| Drummond, GS; Kappas, A | 1 |
| Bottomley, SS | 1 |
| Bothwell, TH; Charlton, RW; Kleber, EE; Simon, MO; Torrance, JD | 1 |
| Maines, MD | 1 |
| Brooker, JD; Elliott, WH; Lim, LK; May, BK; Srivastava, G | 1 |
| Bettany, AJ; Eisenstein, RS; Kikinis, Z; Munro, HN | 1 |
| Atamna, H; Ginsburg, H | 1 |
| Davies, MJ; Muller-Eberhard, U; Timmins, GS | 1 |
| Beuzard, Y; Hebbel, RP; Lubin, BH; Repka, T; Rouyer-Fessard, P; Scott, MD; van den Berg, JJ | 1 |
| Bonkovsky, HL; Cable, EE; Donohue, SE; Lambrecht, RW; Pepe, JA | 1 |
| Bhattacharyya-Pakrasi, M; Gang, H; Goessling, LS; Mascotti, DP; Thach, RE | 1 |
| Bäumler, A; Braun, V; Hantke, K; Heesemann, J; Koebnik, R; Stojiljkovic, I | 1 |
| Barnard, ML; Diep, D; Gurdian, S; Ladd, M; Turrens, JF | 1 |
| Davies, MJ; Muller-Eberhard, U; Song, DX; Timmins, GS | 1 |
| Ponka, P; Richardson, DR; Vyoral, D | 1 |
| Bonkovsky, HL; Cable, EE; Donohue, SE; Gildemeister, OS; Lambrecht, RW; Pepe, JA | 1 |
| Borza, CM; Eskew, JD; Hunt, RC; Pendrak, M; Smith, A | 1 |
| Czyzyk-Krzeska, MF; Kroll, SL | 1 |
| Goessling, LS; Mascotti, DP; Thach, RE | 1 |
| Caro, J; Nakamura, R; Salceda, S; Srinivas, V; Zhu, X | 1 |
| Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T | 1 |
| Franklin Bunn, H; Horiguchi, H | 1 |
| Hejmadi, V; Kvam, E; Pourzand, C; Ryter, S; Tyrrell, RM | 1 |
| Adachi, Y; Nakahashi, Y; Taketani, S | 1 |
| Hirsch-Ernst, KI; Jungermann, K; Kahl, GF; Kietzmann, T; Ziemann, C | 1 |
| Labbe, P; Lesuisse, E | 1 |
| Lee, HC; Zhang, L; Zhu, Y | 1 |
| Fujita, H; Furuyama, K; Hattori, T; Hida, W; Igarashi, K; Kitamuro, T; Nakayama, M; Ogawa, K; Shibahara, S; Shirato, K; Sun, J; Takahashi, K; Takeda, K; Udono-Fujimori, R | 1 |
| BALDINI, M; DAMESHEK, W; STEINER, M | 1 |
| Fujita, H; Igarashi, K; Mori, H; Nakanishi, K; Saito, T; Sun, J; Tahara, T; Taketani, S; Yamamoto, M | 1 |
| Baillie, TA; Kumar, S; Mitra, K; Stearns, RA; Yin, W | 1 |
| Beraud, JJ; Canaud, B; Cristol, JP; Descomps, B; Klouche, K; Morena, M | 1 |
| Reeder, BJ; Wilson, MT | 1 |
| Krishnamurthy, P; Schuetz, JD | 1 |
| Abraham, NG; Ahmad, M; Chow, JL; Gupte, SA; Mingone, CJ; Wolin, MS | 1 |
| Higashimoto, Y; Noguchi, M; Palmer, G; Sakamoto, H; Sato, H; Takahashi, K | 1 |
| Branco, LG; Nascimento, CG | 1 |
| Callaghan, KD; Dailey, LA; Deng, Z; Ghio, AJ; Madden, MD; Nguyen, NB; Piantadosi, CA; Richards, JH; Stonehuerner, JG; Yang, F | 1 |
| Clarke, P; Cuív, PO; Keogh, D; O'Connell, M | 1 |
| Furuyama, K; Sassa, S; Shibahara, S; Vargas, PD | 1 |
| Frei, B; Li, L | 1 |
| Biesalski, HK; Breusing, N; Flaccus, A; Grimm, S; Grune, T; Mvondo, D | 1 |
| Eaton, JW; Lanceta, L; Li, C; Mattingly, JM | 1 |
| Chapman, MS; Davis, SC; de Souza, AL; Gunn, J; Hasan, T; Kanick, SC; Marra, K; Maytin, EV; Pogue, BW; Samkoe, KS | 1 |
| Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H | 1 |
| Pantaleo, A; Pério, P; Reybier, K; Tsamesidis, I | 1 |
| Adamcová, MK; Blazkova, K; Brábek, J; Jadhav, SB; Lettlova, S; Merta, L; Neuzil, J; Rosel, D; Sandoval-Acuña, C; Stursa, J; Tomkova, V; Torrealba, N; Truksa, J; Werner, L | 1 |
| Chen, B; Howley, R; Mansi, M; Restrepo, J; Shinde, J | 1 |
5 review(s) available for heme and deferoxamine
| Article | Year |
|---|---|
Low molecular weight intracellular iron transport compounds.
Topics: Biological Transport; Cell Line; Cytosol; Deferoxamine; Epithelial Cells; Epithelium; Erythrocytes; Ferritins; Heme; Humans; Intestinal Mucosa; Iron; Iron Chelating Agents; Kinetics; Mitochondria; Phagocytes | 1977 |
[Sideroblastic anemias].
Topics: Anemia, Sideroblastic; Bone Marrow Cells; Deferoxamine; Female; Ferritins; Ferrochelatase; Folic Acid; Heme; Hemosiderosis; Humans; Male; Precancerous Conditions; Pyridoxine; Transfusion Reaction; Vitamin B Deficiency | 1978 |
Translational regulation of ferritin synthesis by iron.
Topics: Animals; Base Sequence; Consensus Sequence; Deferoxamine; Ferritins; Gene Expression Regulation; Heme; Hemin; Iron; Models, Biological; Molecular Sequence Data; Protein Biosynthesis; Regulatory Sequences, Nucleic Acid; RNA-Binding Proteins; RNA, Messenger; Sequence Homology, Nucleic Acid | 1990 |
Sideroblastic anaemia.
Topics: 5-Aminolevulinate Synthetase; Adult; Anemia, Sideroblastic; Blood Transfusion; Bone Marrow; Chloramphenicol; Deferoxamine; Erythroblasts; Ethanol; Female; Ferrochelatase; Heme; Hemochromatosis; Humans; Iron Deficiencies; Isoniazid; Male; Melphalan; Myeloproliferative Disorders; Pyridoxine; Syndrome | 1982 |
The ABC transporter Abcg2/Bcrp: role in hypoxia mediated survival.
Topics: Adenosine Triphosphate; Alleles; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; Cell Nucleus; Cell Survival; Cystic Fibrosis Transmembrane Conductance Regulator; Cytoplasm; Deferoxamine; Heme; Humans; Hypoxia; Models, Chemical; Neoplasm Proteins; Oxygen; Phenotype; Polymorphism, Single Nucleotide; Porphyrins; Protein Binding; Protein Structure, Tertiary; Signal Transduction; Stem Cells; Tissue Distribution | 2005 |
81 other study(ies) available for heme and deferoxamine
| Article | Year |
|---|---|
Effect of desferrioxamine and chronic iron deficiency of heme metabolism--comparison with the porphyrogens 2-allyl-2-isopropylacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Deferoxamine; Dicarbethoxydihydrocollidine; Heme; Iron Deficiencies; Liver; Male; Mitochondria, Liver; Porphyrins; Pyridines; Rats; Time Factors | 1979 |
Effective iron chelation following oral administration of an isoniazid-pyridoxal hydrazone.
Topics: Animals; Deferoxamine; Heme; Iron; Iron Chelating Agents; Isoniazid; Liver; Male; Pyridoxal; Pyridoxine; Rats; Spleen | 1979 |
Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.
Topics: 5-Aminolevulinate Synthetase; Animals; Antihypertensive Agents; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Dose-Response Relationship, Drug; Enzyme Induction; Ferrochelatase; Heme; Hydralazine; Liver; Porphyrins | 1978 |
Heme control on the synthesis of delta-aminolevulinic acid synthetase in cultured chick embryo liver cells.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Deferoxamine; Enzyme Induction; Heme; Hemin; Kinetics; Lead; Levulinic Acids; Liver; Phenobarbital; Protein Biosynthesis; Transcription, Genetic | 1975 |
Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.
Topics: Aconitate Hydratase; Animals; Cell Line; Deferoxamine; Dithiothreitol; Edetic Acid; Heme; Humans; Iron; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Recombinant Proteins; RNA-Binding Proteins | 1992 |
Hydroxyl radical formation by sickle erythrocyte membranes: role of pathologic iron deposits and cytoplasmic reducing agents.
Topics: Anemia, Sickle Cell; Ascorbic Acid; Deferoxamine; Erythrocyte Membrane; Free Radicals; Glutathione; Heme; Humans; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Iron; Kinetics; Lipid Peroxidation; NAD; NADP; Oxidation-Reduction; Reference Values | 1991 |
Inhibition of the erythrocyte (Ca2+ + Mg2+)-ATPase by nonheme iron.
Topics: Butylated Hydroxytoluene; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Deferoxamine; Erythrocyte Membrane; Heme; Humans; Iron; Kinetics; Lipid Bilayers; Membrane Lipids; Phospholipids | 1991 |
Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Deferoxamine; Gene Expression Regulation, Enzymologic; Half-Life; Heme; Liver; Models, Biological; RNA, Messenger; Transcription, Genetic | 1991 |
Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.
Topics: Animals; Cell Line; Deferoxamine; Enzyme Induction; Ferritins; Fibroblasts; Heme; Heme Oxygenase (Decyclizing); Iron; Isoniazid; Kinetics; Pyridoxal; Rats | 1991 |
The inhibition of the iron responsive element RNA-protein interaction by heme does not mimic in vivo iron regulation.
Topics: Base Sequence; Carrier Proteins; Cell Line; Cytosol; Deferoxamine; Heme; Humans; Iron-Regulatory Proteins; Kinetics; Molecular Sequence Data; Oligonucleotide Probes; Porphyrins; Restriction Mapping; Rhabdomyosarcoma; RNA, Messenger | 1990 |
Expression of messenger RNA species coding for a Mr 43,000 peptide associated with ferritin in human leukemia-K562 cells and its down regulation during differentiation.
Topics: Cell Line; Deferoxamine; Ferritins; Heme; Humans; Leukemia, Erythroblastic, Acute; Molecular Weight; Neoplasm Proteins; RNA, Messenger; Transcription, Genetic | 1989 |
Iron metabolism in K562 erythroleukemic cells.
Topics: Cell Line; Deferoxamine; Heme; Heptanoates; Humans; Iron; Leukemia, Erythroblastic, Acute; Receptors, Cell Surface; Receptors, Transferrin; Transferrin | 1985 |
Hemin, chelatable iron, and the regulation of transferrin receptor biosynthesis.
Topics: Cell Line; Deferoxamine; Heme; Humans; Iron; Kinetics; Leukemia, Myeloid; Receptors, Cell Surface; Receptors, Transferrin; Transferrin | 1985 |
Control of heme internalization and metabolism in tumor cells: evidence for a heme-receptor?
Topics: Antibodies, Monoclonal; Cell Line; Deferoxamine; Heme; Hemin; Humans; Neoplasms; Receptors, Cell Surface; Receptors, Transferrin | 1986 |
Inhibition of heme-promoted enzymatic lipid peroxidation by desferrioxamine and EDTA.
Topics: Animals; Catalase; Cattle; Deferoxamine; Edetic Acid; Heme; Hemin; Lipid Peroxidation; Methemoglobin; Oxyhemoglobins; Xanthine Oxidase | 1988 |
Induction to erythroid differentiation of K562 cells by 1-beta-D-arabinofuranosylcytosine is inhibited by iron chelators: reversion by treatment with hemin.
Topics: Cell Differentiation; Cell Line; Cytarabine; Deferoxamine; Erythropoiesis; Growth Inhibitors; Heme; Hemin; Hemoglobins; Humans; Kinetics; Leukemia, Erythroblastic, Acute | 1988 |
Increase in surface expression of transferrin receptors on cultured hepatocytes of adult rats in response to iron deficiency.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Cycloheximide; Deferoxamine; Heme; Heptanoates; Kinetics; Liver; Mannans; Rats; Receptors, Transferrin; Reference Values | 1988 |
Haem synthesis from exogenous 5-aminolaevulinate in cultured chick-embryo hepatocytes. Effects of inducers of cytochromes P-450.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Induction; Heme; Levulinic Acids; Liver; Methylcholanthrene; Porphobilinogen; Porphyrins | 1987 |
Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells.
Topics: Animals; Cell Line; Dactinomycin; Deferoxamine; DNA; Ferritins; Heme; Iron; Liver Neoplasms, Experimental; Macromolecular Substances; Polyribosomes; Protein Biosynthesis; Rats; RNA, Messenger | 1987 |
Hemin uptake by erythroleukemic cells treated with iron chelators: effects on the induced expression of differentiated functions.
Topics: Cell Line; Cytarabine; Deferoxamine; Heme; Hemin; Hemoglobins; Humans; Leukemia, Erythroblastic, Acute | 1987 |
Non-ferritin, non-heme iron pools in rat tissues.
Topics: Animals; Deferoxamine; Female; Ferritins; Heme; Iron; Iron Deficiencies; Molecular Weight; Rats; Rats, Inbred Strains; Tissue Distribution | 1986 |
Hematin-derived anticoagulant. Generation in vitro and in vivo.
Topics: Anticoagulants; Blood Coagulation; Blood Coagulation Factors; Deferoxamine; Heme; Hemin; Imidazoles; In Vitro Techniques; Tin | 1986 |
Conversion of 5-aminolaevulinate into haem by homogenates of human liver. Comparison with rat and chick-embryo liver homogenates.
Topics: Aminolevulinic Acid; Animals; Chick Embryo; Deferoxamine; Dithiothreitol; Ferrous Compounds; Heme; Humans; Kinetics; Levulinic Acids; Liver; Models, Biological; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Inbred Strains | 1985 |
The utilization of iron and its complexes by mammalian mitochondria.
Topics: Animals; Antimycin A; Catalysis; Cytochromes; Deferoxamine; Diptera; Electron Transport; Flavoproteins; Heme; In Vitro Techniques; Iron; Iron Chelating Agents; Lyases; Mitochondria; Mitochondria, Liver; Mitochondria, Muscle; NAD; Oxidoreductases; Oxygen Consumption; Rats; Succinates | 1972 |
[Desferrioxamine and heme synthesis. (Relations of desferrioxamine, protoporphyrin and blood)].
Topics: Animals; Blood; Deferoxamine; Heme; In Vitro Techniques; Porphyrins; Poultry; Rabbits | 1966 |
Studies on iron metabolism with desferrioxamine in man. Experimental and clinical studies.
Topics: Adult; Aged; Allopurinol; Anemia, Hypochromic; Blood Transfusion; Deferoxamine; Diet; Erythrocytes; Feces; Female; Heme; Hemochromatosis; Hemolysis; Hemosiderosis; Humans; Injections, Intramuscular; Injections, Intravenous; Intestinal Absorption; Iron; Iron Chelating Agents; Iron Isotopes; Iron-Dextran Complex; Kidney; Male; Methods; Middle Aged; Nicotinic Acids; Sex Factors; Time Factors; Xanthine Oxidase | 1969 |
Ferrioxamine iron in rabbit reticulocyte heme synthesis.
Topics: Amino Acids; Animals; Biological Transport; Cell Membrane; Cell Membrane Permeability; Deferoxamine; Heme; Hemochromatosis; Iron; Iron Chelating Agents; Iron Isotopes; Rabbits; Reticulocytes; Transferrin | 1970 |
[Significance of disorders of hemoglobin synthesis for the clinical practice].
Topics: Anemia, Macrocytic; Anemia, Sickle Cell; Deferoxamine; Erythrocyte Aging; Erythropoiesis; Hematologic Diseases; Heme; Hemoglobinopathies; Hemoglobins; Hemoglobins, Abnormal; Humans; Methemoglobinemia; Mitochondria; Peptide Biosynthesis | 1967 |
Absorption of hemoglobin iron: the role of a heme-splitting substance in the intestinal mucosa.
Topics: Absorption; Animals; Blood Proteins; Brain; Deferoxamine; Deficiency Diseases; Digestive System; Dogs; Ferritins; Heme; Hemoglobins; Intestinal Mucosa; Iron; Iron Isotopes; Iron-Dextran Complex; Kinetics; Molecular Weight; Temperature; Time Factors | 1968 |
Mechanism of action of sideromycins.
Topics: Anti-Bacterial Agents; Carbohydrate Metabolism; Citric Acid Cycle; Culture Media; Deferoxamine; Drug Resistance, Microbial; Heme; Hexoses; In Vitro Techniques; Iron; Keto Acids; Mutation; Nicotinic Acids; Oxaloacetates; Pentoses; Pyruvates; Staphylococcus; Thiamine | 1965 |
Regulation of rat hepatic delta-aminolevulinic acid synthetase and heme oxygenase activities: evidence for control by heme and against mediation by prosthetic iron.
Topics: 5-Aminolevulinate Synthetase; Animals; Bilirubin; Cobalt; Deferoxamine; Dextrans; Edetic Acid; Heme; Heme Oxygenase (Decyclizing); Iron-Dextran Complex; Kinetics; Liver; Male; Mixed Function Oxygenases; Protoporphyrins; Rats | 1983 |
Malaria and iron.
Topics: Deferoxamine; Female; Heme; Humans; Iron Deficiencies; Malaria; Plasmodium; Plasmodium falciparum; Pregnancy; Transferrin | 1983 |
Desferrioxamine-mediated inhibition of heme and hemoglobin synthesis in murine erythroleukemia cells: expression of globin genes and commitment to erythroid differentiation.
Topics: Acetamides; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Deferoxamine; Erythropoiesis; Gene Expression Regulation; Globins; Heme; Hemoglobins; Leukemia, Erythroblastic, Acute; Mice | 1983 |
[Inhibition of heme biosynthesis in erythroid precursors (BFU-e) isolated from human peripheral blood: effects on globin synthesis].
Topics: Chromatography, Ion Exchange; Deferoxamine; Erythroblasts; Erythropoietin; Globins; Heme; Humans; Kinetics; Protein Biosynthesis | 1983 |
Desferrioxamine inhibits induced erythroid differentiation of human leukemic K-562 cells.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Cell Division; Deferoxamine; Erythroblasts; Erythrocytes; Gene Expression Regulation; Globins; Heme; Humans; Iron; Leukemia | 1983 |
Potent heme-degrading action of antimony and antimony-containing parasiticidal agents.
Topics: 5-Aminolevulinate Synthetase; Animals; Anti-Infective Agents; Antimony; Cobalt; Cysteine; Deferoxamine; Dose-Response Relationship, Drug; Heme; Heme Oxygenase (Decyclizing); Kidney; Liver; Male; Rats; Time Factors; Zinc | 1981 |
Mobilisation of iron from peritoneal rat macrophages by desferrioxamine.
Topics: Animals; Deferoxamine; Ferritins; Heme; Hemoglobins; Iron; Iron Radioisotopes; Macrophages; Male; Mononuclear Phagocyte System; Rats; Rats, Inbred Strains; Time Factors | 1981 |
Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Deferoxamine; Glutathione; Heme; Iron; Kinetics; Lipid Peroxides; Liver; Male; Microsomes, Liver; Porphyrins; Rats | 1980 |
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Microsomes, Liver; Phenobarbital; Porphyrias; Proadifen | 1980 |
Role of RNA secondary structure of the iron-responsive element in translational regulation of ferritin synthesis.
Topics: Animals; Base Sequence; Cell Line; Chelating Agents; Deferoxamine; Ferritins; Fibroblasts; Genes, Reporter; Heme; Iron; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Biosynthesis; Rats; RNA, Messenger | 1995 |
Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells.
Topics: Deferoxamine; Erythrocyte Membrane; Glutathione; Heme; Hemoglobinopathies; Humans; Hydrogen Peroxide; Iron; Pentose Phosphate Pathway | 1995 |
A study of the effects of complexation of heme by hemopexin upon its reactions with organic peroxides.
Topics: Cyclic N-Oxides; Deferoxamine; Electron Spin Resonance Spectroscopy; Heme; Hemopexin; Humans; Peroxides; Reactive Oxygen Species; Spin Labels; tert-Butylhydroperoxide | 1995 |
Effect of excess alpha-hemoglobin chains on cellular and membrane oxidation in model beta-thalassemic erythrocytes.
Topics: Amitrole; Antioxidants; beta-Thalassemia; Deferoxamine; Dextrans; Erythrocyte Deformability; Erythrocyte Membrane; Erythrocytes; Glutathione; Heme; Hemoglobins; Humans; Iron; Lipid Peroxidation; Mass Spectrometry; Membrane Proteins; Oxidation-Reduction; Peroxides; Reactive Oxygen Species | 1993 |
Effects of mifepristone (RU-486) on heme metabolism and cytochromes P-450 in cultured chick embryo liver cells, possible implications for acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Heme; Liver; Mifepristone; Porphyrias, Hepatic; Porphyrins; RNA, Messenger | 1994 |
Irreversible steps in the ferritin synthesis induction pathway.
Topics: Animals; Cell Line; Cycloheximide; Deferoxamine; Ferritins; Heme; In Vitro Techniques; Iron; Iron-Regulatory Proteins; Rabbits; RNA-Binding Proteins; Time Factors | 1994 |
Survey on newly characterized iron uptake systems of Yersinia enterocolitica.
Topics: Bacterial Proteins; Bacteriocins; Biological Transport, Active; Catechols; Deferoxamine; Escherichia coli; Escherichia coli Proteins; Ferric Compounds; Ferrichrome; Genes, Bacterial; Heme; Iron; Membrane Proteins; Mutation; Virulence; Yersinia enterocolitica | 1993 |
Protein and amino acid oxidation is associated with increased chemiluminescence.
Topics: Antioxidants; Deferoxamine; Dimethyl Sulfoxide; Ethylamines; Heme; Histidine; Kinetics; Luminescent Measurements; Oxidation-Reduction; Oxygen Consumption; Peroxides; Piperazines; Pyridines; Serum Albumin, Bovine; Superoxide Dismutase; tert-Butylhydroperoxide; Tryptophan; Tyrosine | 1993 |
EPR studies on the effects of complexation of heme by hemopexin upon its reactions with organic peroxides.
Topics: Benzene Derivatives; Cyclic N-Oxides; Deferoxamine; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Hemopexin; Oxidation-Reduction; Peroxides; Reactive Oxygen Species; Spin Trapping; tert-Butylhydroperoxide | 1995 |
Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: examination of the intermediates involved in iron metabolism.
Topics: Animals; Blood Proteins; Cell Compartmentation; Cytosol; Deferoxamine; Enzyme Inhibitors; Heme; Hemoglobins; Heptanoates; Iron; Iron Chelating Agents; Membrane Proteins; Mitochondria; Models, Biological; Porphobilinogen Synthase; Protoporphyrins; Rabbits; Reticulocytes; Transferrin | 1996 |
Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Dactinomycin; Deferoxamine; Enzyme Inhibitors; Glutethimide; Heme; Heptanoates; Kinetics; Liver; Metalloporphyrins; Porphobilinogen Synthase; Regression Analysis; RNA, Messenger | 1996 |
Role of heme-hemopexin in human T-lymphocyte proliferation.
Topics: Animals; Cell Division; Deferoxamine; Heme; Hemopexin; Humans; Iron; Leukemia-Lymphoma, Adult T-Cell; Mice; Neoplasm Proteins; Protein Kinase C; Protoporphyrins; Receptors, Peptide; T-Lymphocytes; Tumor Cells, Cultured | 1997 |
Role of H2O2 and heme-containing O2 sensors in hypoxic regulation of tyrosine hydroxylase gene expression.
Topics: Acetylcysteine; Actins; Amitrole; Animals; Antioxidants; Biosensing Techniques; Catalase; Cell Hypoxia; Deferoxamine; Gene Expression Regulation, Enzymologic; Heme; Hydrogen Peroxide; Kinetics; Oxygen; PC12 Cells; Rats; RNA, Messenger; Tiopronin; Transcription, Genetic; Tyrosine 3-Monooxygenase | 1998 |
Involvement of heme in the degradation of iron-regulatory protein 2.
Topics: Animals; Cell Line; Deferoxamine; Heme; Hydrolysis; Iron; Iron Chelating Agents; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Rabbits; RNA-Binding Proteins | 1998 |
Hypoxia-inducible factor 1alpha (HIF-1alpha) is a non-heme iron protein. Implications for oxygen sensing.
Topics: Carbon Monoxide; Cell Hypoxia; Cell Line; Deferoxamine; DNA-Binding Proteins; Helix-Loop-Helix Motifs; Heme; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Iron Chelating Agents; Luciferases; Nuclear Proteins; Oxygen; Transcription Factors | 1998 |
Mimicry in primary rat hepatocyte cultures of the in vivo perivenous induction by phenobarbital of cytochrome P-450 2B1 mRNA: role of epidermal growth factor and perivenous oxygen tension.
Topics: Animals; Arteries; Cell Membrane; Chelating Agents; Cobalt; Cytochrome P-450 CYP2B1; Deferoxamine; Enzyme Induction; Enzyme Repression; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Growth Hormone; Heme; In Vitro Techniques; Liver; Male; Molecular Mimicry; Oxygen; Phenobarbital; Rats; Rats, Wistar; RNA, Messenger; Thyroxine | 1999 |
Erythropoietin induction in Hep3B cells is not affected by inhibition of heme biosynthesis.
Topics: Cell Survival; Deferoxamine; Enzyme Inhibitors; Erythropoietin; Heme; Heptanoates; Humans; Isoniazid; Protoporphyrins; Tumor Cells, Cultured | 2000 |
Heme oxygenase activity causes transient hypersensitivity to oxidative ultraviolet A radiation that depends on release of iron from heme.
Topics: Cell Survival; Deferoxamine; HeLa Cells; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Iron; Iron Chelating Agents; Oxidation-Reduction; Oxidative Stress; Photochemistry; Radiation Tolerance; Recombinant Fusion Proteins; Transfection; Ultraviolet Rays | 2000 |
Regulation of the expression of human ferrochelatase by intracellular iron levels.
Topics: Animals; Chelating Agents; Coproporphyrinogen Oxidase; COS Cells; Cytoplasm; Deferoxamine; Dose-Response Relationship, Drug; Escherichia coli; Ferric Compounds; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Humans; Immunoblotting; Iron; K562 Cells; Mitochondria; Mutagens; Nitrilotriacetic Acid; Plasmids; RNA, Messenger; Time Factors | 2000 |
Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures.
Topics: Animals; Arteries; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Blotting, Northern; Cells, Cultured; Chelating Agents; Cobalt; Dactinomycin; Deferoxamine; Fluorescent Dyes; Heme; Hepatocytes; Immunoblotting; Male; Nucleic Acid Synthesis Inhibitors; Oxygen; Rats; Rats, Wistar; Rhodamine 123; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Veins | 2000 |
Reductive and non-reductive mechanisms of iron assimilation by the yeast Saccharomyces cerevisiae.
Topics: Aminolevulinic Acid; Culture Media; Deferoxamine; Ferric Compounds; FMN Reductase; Heme; Iron; Iron Chelating Agents; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Saccharomyces cerevisiae | 1989 |
An examination of heme action in gene expression: heme and heme deficiency affect the expression of diverse genes in erythroid k562 and neuronal PC12 cells.
Topics: Actins; Animals; Cell Cycle Proteins; Cell Differentiation; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Deferoxamine; Enzyme Inhibitors; Erythropoiesis; Gene Expression Profiling; Gene Expression Regulation; Heme; Heptanoates; Humans; Iron Chelating Agents; K562 Cells; Neurons; Oligonucleotide Array Sequence Analysis; PC12 Cells; Rats; Tumor Suppressor Proteins | 2002 |
Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Blotting, Northern; Blotting, Western; Cattle; Cell Line; Cobalt; Dactinomycin; Deferoxamine; Dimerization; Fanconi Anemia Complementation Group Proteins; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hypoxia; Interferon-gamma; Leucine Zippers; Luciferases; Membrane Proteins; Models, Genetic; Oxidative Stress; Oxygen; Promoter Regions, Genetic; Rats; RNA, Messenger; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured | 2003 |
ENZYMATIC DEFECTS OF HEME SYNTHESIS IN THALASSEMIA.
Topics: Amino Acid Oxidoreductases; Bone Marrow Examination; Deferoxamine; Drug Therapy; Erythropoiesis; Heme; Humans; Levulinic Acids; Ligases; Metabolism; Thalassemia | 1964 |
Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Binding Sites; Blotting, Northern; Cell Line; Chelating Agents; Chromatin; Deferoxamine; Dimerization; Erythroid Cells; Fanconi Anemia Complementation Group Proteins; Gene Deletion; Gene Expression Regulation; Genes, Reporter; Globins; Heme; Heptanoates; Humans; Iron; K562 Cells; Leukemia, Erythroblastic, Acute; Mice; Mice, Inbred BALB C; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; RNA; RNA, Messenger; Transcription Factors | 2004 |
Conversion of the 2,2,6,6-tetramethylpiperidine moiety to a 2,2-dimethylpyrrolidine by cytochrome P450: evidence for a mechanism involving nitroxide radicals and heme iron.
Topics: Aerobiosis; Anaerobiosis; Carbon Monoxide; Cyclic N-Oxides; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Deferoxamine; Free Radicals; Heme; Hemin; Humans; Iron; Iron Chelating Agents; Microsomes, Liver; NADP; Nitrogen Oxides; Oxygen Isotopes; Piperidones; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Triacetoneamine-N-Oxyl | 2004 |
Mechanism of in vitro heme-induced LDL oxidation: effects of antioxidants.
Topics: Antioxidants; Deferoxamine; Dose-Response Relationship, Drug; Heme; Humans; Hydrogen Peroxide; Iron Chelating Agents; Lipid Peroxidation; Lipoproteins, LDL; Oxidation-Reduction; Protoporphyrins; Vitamins | 2004 |
Desferrioxamine inhibits production of cytotoxic heme to protein cross-linked myoglobin: a mechanism to protect against oxidative stress without iron chelation.
Topics: Animals; Cross-Linking Reagents; Deferoxamine; Heme; Horses; Iron Chelating Agents; Liposomes; Metmyoglobin; Myoglobin; Oxidation-Reduction; Oxidative Stress; Phospholipids | 2005 |
Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation.
Topics: Aminolevulinic Acid; Animals; Cattle; Deferoxamine; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heme; Iron; Models, Biological; Organ Culture Techniques; Oxidation-Reduction; Photosensitizing Agents; Protoporphyrins; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Serotonin; Soluble Guanylyl Cyclase; Vasodilation | 2006 |
The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN.
Topics: Animals; Binding Sites; Deferoxamine; Ferricyanides; Flavin Mononucleotide; Heme; Heme Oxygenase-1; Humans; Models, Chemical; Models, Molecular; Mutation; NADPH-Ferrihemoprotein Reductase; Rats | 2006 |
Role of the peripheral heme oxygenase-carbon monoxide pathway on the nociceptive response of rats to the formalin test: evidence for a cGMP signaling pathway.
Topics: Animals; Biliverdine; Carbon Monoxide; Cyclic GMP; Deferoxamine; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Iron Chelating Agents; Lysine; Male; Pain; Pain Measurement; Rats; Rats, Wistar; Signal Transduction | 2007 |
Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function.
Topics: Acetaldehyde; Animals; Antimetabolites; Antioxidants; Bronchoalveolar Lavage; Carbon Monoxide; Cell Line; Cell Proliferation; Child; Deferoxamine; Epithelial Cells; Ferritins; Heme; Homeostasis; Humans; Interleukin-8; Iron; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Respiratory Mucosa; Siderophores | 2008 |
The hmuUV genes of Sinorhizobium meliloti 2011 encode the permease and ATPase components of an ABC transport system for the utilization of both haem and the hydroxamate siderophores, ferrichrome and ferrioxamine B.
Topics: Adenosine Triphosphatases; ATP-Binding Cassette Transporters; Bacterial Outer Membrane Proteins; Biological Transport; Cosmids; Deferoxamine; DNA, Bacterial; Escherichia coli; Ferric Compounds; Ferrichrome; Genes, Bacterial; Heme; Hydroxamic Acids; Iron; Medicago sativa; Mutagenesis; Mutation; Nitrogen Fixation; Periplasmic Binding Proteins; Siderophores; Sinorhizobium meliloti; Transformation, Bacterial | 2008 |
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.
Topics: Blotting, Northern; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; Gene Expression Regulation, Enzymologic; Heme; Humans; Hydroxymethylbilane Synthase; Isoenzymes; Jurkat Cells; K562 Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA, Messenger; Tetrapyrroles; Uroporphyrinogen III Synthetase | 2008 |
Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine.
Topics: Aorta; Atherosclerosis; Cells, Cultured; Deferoxamine; Endothelial Cells; Heme; Humans; Iron; Lipopolysaccharides; NADPH Oxidases; Oxidative Stress | 2009 |
Light-induced cytotoxicity after aminolevulinic acid treatment is mediated by heme and not by iron.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Deferoxamine; Heme; Heme Oxygenase-1; Humans; Iron; Iron Chelating Agents; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species | 2010 |
How Heme Oxygenase-1 Prevents Heme-Induced Cell Death.
Topics: Cell Death; Cell Line, Tumor; Deferoxamine; Ferritins; Gene Expression Regulation; Gene Knockdown Techniques; Heme; Heme Oxygenase-1; Humans; Lysosomes | 2015 |
Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Female; Heme; Humans; Lasers, Semiconductor; Lighting; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Random Allocation; Siderophores; Skin Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Oxygen; Photosensitivity Disorders; Photosensitizing Agents; Porphyrias; Porphyrins; Protein Aggregates; Protein Conformation; Protoporphyrins | 2019 |
Oxidation of Erythrocytes Enhance the Production of Reactive Species in the Presence of Artemisinins.
Topics: Artemisinins; Deferoxamine; Erythrocytes; Female; Heme; Hemoglobins; Humans; Hydrogen Peroxide; Iron; Male; Methemoglobin; Middle Aged; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxyhemoglobins; Reactive Oxygen Species; Superoxides | 2020 |
Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy.
Topics: Animals; Carcinogenesis; Cell Death; Cell Movement; Cell Proliferation; Deferoxamine; Heme; Humans; Iron; Iron Chelating Agents; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mitochondria; Mitophagy; Neoplasms; PC-3 Cells; Reactive Oxygen Species; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2021 |
Analysis of Renal Cell Carcinoma Cell Response to the Enhancement of 5-aminolevulinic Acid-mediated Protoporphyrin IX Fluorescence by Iron Chelator Deferoxamine
Topics: Aminolevulinic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Deferoxamine; Fluorescence; Heme; Humans; Iron; Iron Chelating Agents; Kidney Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2023 |