heme and cyclic gmp
heme has been researched along with cyclic gmp in 94 studies
Research
Studies (94)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 14 (14.89) | 18.7374 |
1990's | 15 (15.96) | 18.2507 |
2000's | 34 (36.17) | 29.6817 |
2010's | 19 (20.21) | 24.3611 |
2020's | 12 (12.77) | 2.80 |
Authors
Authors | Studies |
---|---|
Arnold, WP; Braughler, JM; Mittal, CK; Murad, F | 1 |
Stewart, PR | 1 |
Ernst, V; Fifer, MA; Levin, DH; London, LM; Ranu, RS | 1 |
Bomboy, JD; Graber, SE; Krantz, SB; Salmon, WD | 1 |
Ignarro, LJ | 2 |
Ignarro, LJ; Wood, KS | 1 |
Schini, VB; Vanhoutte, PM | 1 |
Buga, GM; Byrns, RE; Ignarro, LJ; Wood, KS | 1 |
Carrillo, M; Graber, SE; Krantz, SB | 1 |
Edwards, PM; Frankena, H; Schotman, P; Schrama, LH | 1 |
Craven, PA; Derubertis, FR; Saito, R | 1 |
Briggs, RG; Derubertis, FR | 1 |
Hyman, AL; Ignarro, LJ; Kadowitz, PJ; McNamara, DB | 1 |
George, WJ; White, LE | 1 |
Fisher, JW; George, WJ; White, L | 1 |
Böhme, E; Foerster, J; Harteneck, C; Humbert, P; Koesling, D; Malkewitz, J; Schultz, G; Wedel, B | 1 |
Severina, IS | 1 |
Chamulitrat, W; Cutler, RG; Jordan, SJ; Mason, RP; Saito, K | 1 |
Marletta, MA; Stone, JR | 1 |
Cheng, J; Ingi, T; Ronnett, GV | 1 |
Bina, S; Hart, JL; Jing, M; Muldoon, SM; Verma, A | 1 |
Chiang, G; Ingi, T; Ronnett, GV | 1 |
Imai, Y; Kitagawa, T; Tomita, T; Tsuyama, S | 1 |
Awtrey, CS; Colgan, SP; Lisco, SJ; Taylor, CT | 1 |
Axelsson, O; Bang, L; Busse, R; Drejer, J; Moldt, P; Mülsch, A; Nielsen-Kudsk, JE; Olesen, SP | 1 |
Burstyn, JN; Dierks, EA | 1 |
Fedinec, AL; Johnson, RA; Leffler, CW; Nasjletti, A; Walker, N; Yu, C | 1 |
Gupte, SA; Phillibert, D; Rupawalla, T; Wolin, MS | 1 |
Bouzhir, L; Liebl, U; Martin, JL; Négrerie, M | 1 |
Bellamy, TC; Garthwaite, J; Wood, J | 1 |
Branco, LG; Steiner, AA | 1 |
Abraham, NG; Balazy, M; Jiang, H; Quan, S; Schwartzman, ML; Shenouda, S; Shibahara, I; Shinohara, K; Yang, L | 1 |
Bada, HS; Daley, ML; Korones, SB; Leffler, CW; Parfenova, H; Pourcyrous, M | 1 |
Abraham, NG; Burke-Wolin, T; Goodman, AI; Mieyal, PA; Mingone, CJ; Nasjletti, A; Quan, S; Wolin, MS; Yang, L | 1 |
Naik, JS; Walker, BR | 1 |
Abraham, NG; Gupte, SA; Mingone, CJ; Quan, S; Wolin, MS | 1 |
Bartberger, MD; Espey, MG; Feelisch, M; Ford, E; Fukuto, JM; Kass, DA; Katori, T; Miranda, KM; Paolocci, N; Thomas, DD; Wink, DA | 1 |
Schmidt, P; Schramm, M; Schröder, H; Stasch, JP | 1 |
Samouilov, A; Tiravanti, E; Zweier, JL | 1 |
Bargmann, CI; Chang, AJ; Chang, JS; Ellis, RE; Gray, JM; Karow, DS; Lu, H; Marletta, MA | 1 |
Leelavanichkul, K; Pitt, BR; St Croix, CM; Stitt, MS; Wasserloos, KJ; Watkins, SC | 1 |
Koesling, D; Russwurm, M | 2 |
Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F | 1 |
Chacko, BK; Crawford, JH; Darley-Usmar, VM; Gladwin, MT; Ho, C; Huang, Z; Isbell, TS; Kerby, JD; Kraus, D; Lang, JD; Patel, RP; Schechter, AN; Shiva, S | 1 |
Cary, SP; Derbyshire, ER; Marletta, MA; Winger, JA | 1 |
Rothkegel, C; Schmidt, HH; Schmidt, PM; Schröder, H; Stasch, JP; Stoll, F | 1 |
Almeida, MC; Branco, LG; Ravanelli, MI | 1 |
Deile, M; H S, AK; Kemp-Harper, B; Knorr, A; Lapp, H; Meurer, S; Müller, H; Müller-Esterl, W; Nedvetskaya, TY; Nedvetsky, PI; Rothkegel, C; Schmidt, HH; Schmidt, PM; Stasch, JP; Taye, A; Tersteegen, A; Turgay, Y | 1 |
Branco, LG; Nascimento, CG | 2 |
Boerrigter, G; Burnett, JC | 1 |
Shimizu, T; Takahashi, H; Tanaka, A | 1 |
Garthwaite, J; Mo, E; Roy, B; Vernon, J | 1 |
Branco, LG; Ravanelli, MI | 1 |
Chaudhuri, G; Fukuto, JM; Pervin, S; Singh, R; Tran, AH; Zekavati, S | 1 |
Tsoukias, NM | 1 |
Araki, Y; Igarashi, J; Ishitsuka, Y; Ito, O; Shimizu, T; Tanaka, A | 1 |
Baik, HS; Cho, HJ; Cho, HY; Eom, CY; Kang, BS; Kim, YM; Ko, IJ; Lee, JM; Oh, JH; Oh, JI; Park, SW | 1 |
Dalkas, G; Kotanidou, A; Papapetropoulos, A; Pyriochou, A; Roussos, C; Spyroulias, G; van Eickels, M; Zhou, Z | 1 |
Shimizu, T; Tanaka, A | 1 |
Beckhaus, T; Gegenbauer, K; Geschka, S; Karas, M; Matt, S; Meurer, S; Müller-Esterl, W; Opitz, N; Pabst, T; Pioch, S; Schmidt, HH; Schmidt, PM; Stasch, JP; Wagner, K | 1 |
Jadhav, A; Ndisang, JF | 1 |
Gilles-Gonzalez, MA; Gonzalez, G; Tuckerman, JR | 1 |
Ducsay, CA; Myers, DA | 1 |
Hoffmann, C; Hoffmann, LS; Keim, Y; Schmidt, HH; Schmidt, PM; Stasch, JP | 1 |
Berka, V; Martin, E; Sharina, I; Tsai, AL | 1 |
Bedja, D; Danner, T; Friebe, A; Jasmin, JF; Kass, DA; Koitabashi, N; Lisanti, MP; Liu, Y; Takimoto, E; Tsai, EJ | 1 |
Igarashi, J; Sekimoto, M; Shimizu, T; Takahashi, H; Tanaka, A; Tanaka, M | 1 |
Gorren, AC; Kolesnik, B; Mayer, B; Neubauer, A; Schmidt, K; Stasch, JP; Werner, ER | 1 |
Barnucz, E; Hegedüs, P; Hirschberg, K; Karck, M; Korkmaz, S; Li, S; Loganathan, S; Mikles, B; Páli, S; Radovits, T; Szabó, G; Weymann, A | 1 |
Hori, H; Makino, R; Shiro, Y; Yazawa, S | 1 |
Klose, KE; Kurtz, DM; Miner, KD | 1 |
Boon, EM; Lahiri, T; Luan, B; Raleigh, DP | 1 |
Chibbar, R; Lane, N; Ndisang, JF | 1 |
Branco, LG; Carvalho-Costa, PG; Leite-Panissi, CR | 1 |
Hocher, B; Hoffmann, LS; Kretschmer, A; Lawrenz, B; Stasch, JP | 1 |
Burns, JL; Deer, DD; Dvorak, D; Joynt, SC; Rivera, S; Weinert, EE | 1 |
Boydens, C; Brouckaert, P; Buys, ES; Decaluwé, K; Pauwels, B; Thoonen, R; Van de Voorde, J | 1 |
Kleschyov, AL | 1 |
Arora, DP; Bacon, B; Binnenkade, L; Boon, EM; Brutinel, ED; Drescher, K; Gralnick, JA; Hartmann, R; Hossain, S; Kotloski, NJ; Muralidharan, S; Nisbett, LM; Thormann, KM | 1 |
Bloch, W; Deschner, J; Friebe, A; Galler, K; Gölz, L; Kämmerer, PW; Korkmaz, Y; Puladi, B; Schröder, A; Sparwasser, T | 1 |
Dai, Y; Stuehr, DJ | 2 |
Armache, JP; Das, S; Kincaid, JR; Liu, Y; Patterson, DC; Weinert, EE; Yennawar, NH | 1 |
Dai, Y; Faul, EM; Ghosh, A; Stuehr, DJ | 1 |
Dietz, L; Gerisch, M; Hüser, J; Janssen, W; Mulder-Jongen, DAJ; Nelissen, E; Possemis, N; Prickaerts, J; Sandner, P; Schepers, M; Van Goethem, NP; Vanmierlo, T | 1 |
Gnipp, S; Koesling, D; Mergia, E; Peters, M; Puschkarow, M; Verheyen, M | 1 |
Bloch, W; Demirbas, A; Deschner, J; Korkmaz, Y; Plomann, M; Puladi, B | 1 |
Chen, L; Kang, Y; Liu, R | 1 |
Benardeau, A; Eitner, F; Ellinger-Ziegelbauer, H; Freyberger, A; Geiss, V; Hagelschuer, I; Hahn, MG; Hartmann, E; Hueser, J; Kraehling, JR; Mathar, I; Pavkovic, M; Popp, L; Sandner, P; Schomber, T; Siudak, K; Vienenkoetter, J | 1 |
Hoque, NJ; Weinert, EE | 1 |
Bronckaers, A; Foulquier, S; Nelissen, E; Ponsaerts, L; Prickaerts, J; Sandner, P; Schepers, M; Vanmierlo, T | 1 |
Reviews
11 review(s) available for heme and cyclic gmp
Article | Year |
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Properties and regulation of guanylate cyclase and some proposed functions for cyclic GMP.
Topics: Animals; Azides; Cyclic GMP; Dehydroascorbic Acid; Detergents; Enterotoxins; Enzyme Activation; Escherichia coli; Guanylate Cyclase; Heme; Hormones; Intestinal Mucosa; Kinetics; Molecular Weight; Muscle, Smooth; Nitric Oxide; Oxidation-Reduction; Subcellular Fractions; Sulfhydryl Compounds | 1979 |
Analytical methods for yeasts.
Topics: Adenine Nucleotides; Amino Acids; Carbohydrates; Cell Fractionation; Chitin; Cyclic AMP; Cyclic GMP; Cytochromes; DNA; Fungal Proteins; Glycogen; Glycoproteins; Heme; Immunoassay; Lipids; Mannans; Mitochondria; Polysaccharides; Porphyrins; RNA; Subcellular Fractions; Yeasts | 1975 |
Signal transduction mechanisms involving nitric oxide.
Topics: Animals; Cell Communication; Cyclic GMP; Heme; Humans; Nitric Oxide; Signal Transduction | 1991 |
Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: a unique transduction mechanism for transcellular signaling.
Topics: Animals; Cell Communication; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Nitric Oxide; Signal Transduction | 1990 |
Guanylyl cyclase: NO hits its target.
Topics: Animals; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Humans; Isoenzymes; Models, Chemical; Nitric Oxide; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tissue Distribution | 2004 |
Nitric oxide signaling: no longer simply on or off.
Topics: Animals; Cyclic GMP; Guanylate Cyclase; Heme; Humans; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Signal Transduction | 2006 |
Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease.
Topics: Animals; Antihypertensive Agents; Benzoates; Cardiovascular Diseases; Cell Adhesion; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heart Failure; Heme; Humans; Hypertension; Hypertension, Pulmonary; Inflammation; Leukocytes; Nitric Oxide; Platelet Aggregation; Pyrazoles; Pyridines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilator Agents | 2007 |
Nitric oxide bioavailability in the microcirculation: insights from mathematical models.
Topics: Animals; Cyclic GMP; Cysteine; Diffusion; Endothelium, Vascular; Erythrocytes; Guanylate Cyclase; Heme; Hemoglobins; Humans; Microcirculation; Microvessels; Models, Cardiovascular; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Sulfhydryl Compounds; Vasodilation | 2008 |
eNOS activation and NO function: differential control of steroidogenesis by nitric oxide and its adaptation with hypoxia.
Topics: Adrenal Glands; Animals; Cyclic GMP; Cysteine; Enzyme Activation; Female; Guanylate Cyclase; Heme; Humans; Hypoxia; Male; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type III; Ovary; Pregnancy; Protein Processing, Post-Translational; Steroids; Testis; Tyrosine | 2011 |
Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins.
Topics: Bacteria; Bacterial Proteins; Biofilms; Cyclic GMP; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Heme; Hemeproteins; Oxygen; Second Messenger Systems | 2023 |
Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?
Topics: Cognitive Dysfunction; Cyclic GMP; Heme; Humans; Inflammation; Soluble Guanylyl Cyclase; Vascular Diseases | 2023 |
Other Studies
83 other study(ies) available for heme and cyclic gmp
Article | Year |
---|---|
Association of a cyclic AMP-dependent protein kinase with a purified translational inhibitor isolated from hemin-deficient rabbit reticulocyte lysates.
Topics: Animals; Binding Sites; Blood Proteins; Cyclic AMP; Cyclic GMP; Enzyme Activation; Heme; Hemin; Isoenzymes; Kinetics; Macromolecular Substances; Protein Binding; Protein Biosynthesis; Protein Kinases; Rabbits; Reticulocytes | 1975 |
Effect of erythropoietin preparations on cyclic AMP and cyclic GMP levels in rat fetal liver cell cultures.
Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Erythropoietin; Gestational Age; Heme; Liver; Phosphodiesterase Inhibitors; Rats; Xanthines | 1977 |
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine | 1987 |
SIN-1 stimulates the production of cyclic GMP but not cyclic AMP in porcine aortic endothelial cells.
Topics: Animals; Aorta, Thoracic; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Heme; Methylene Blue; Molsidomine; Rodentia; Vasodilator Agents | 1989 |
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.
Topics: Acetylcholine; Animals; Biological Products; Bradykinin; Carbon Monoxide; Cattle; Cyclic GMP; Endothelium, Vascular; Free Radicals; Guanylate Cyclase; Heme; Metalloporphyrins; Muscle Relaxation; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Oxyhemoglobins; Pulmonary Artery; Pulmonary Veins; Pyrogallol; Superoxide Dismutase | 1987 |
The effect of cyclic AMP on heme synthesis by rat bone marrow cells.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Bone Marrow; Bone Marrow Cells; Butyrates; Cells, Cultured; Cyclic AMP; Cyclic GMP; Depression, Chemical; Dose-Response Relationship, Drug; Epinephrine; Erythropoietin; Heme; Imidazoles; In Vitro Techniques; Insulin; Iron; Iron Isotopes; Male; Rats; Stimulation, Chemical; Transferrin; Xanthines | 1972 |
Cyclic nucleotide- and calcium-independent phosphorylation of proteins in rat brain polyribosome: effects of ACTH, spermine, and hemin.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Cyclic AMP; Cyclic GMP; Heme; Hemin; In Vitro Techniques; Nerve Tissue Proteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinases; Rats; Spermine | 1984 |
Studies of N-methyl-N'-nitro-N-nitrosoguanidine action on the guanylate cyclase-guanosine 3'5' monophosphate system of isolated colonic epithelial cells.
Topics: Animals; Biotransformation; Colon; Cyclic AMP; Cyclic GMP; Dithiothreitol; Enzyme Activation; Epithelium; Guanylate Cyclase; Heme; In Vitro Techniques; Male; Methylnitronitrosoguanidine; Nitric Oxide; Nitrites; Rabbits | 1980 |
Increased responsiveness of the hepatic guanylate cyclase-guanosine 3',5'-monophosphate system to nitrosoguanidine following partial hepatectomy.
Topics: Animals; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Hepatectomy; Liver; Liver Regeneration; Male; Methylnitronitrosoguanidine; Rats; Subcellular Fractions | 1980 |
Adenosine 3',5'-monophosphate formation by preparations of rat liver soluble guanylate cyclase activated with nitric oxide, nitrosyl ferroheme, S-nitrosothiols, and other nitroso compounds.
Topics: Adenosine Triphosphate; Animals; Cyclic AMP; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Hemeproteins; Kinetics; Liver; Male; Methylnitronitrosoguanidine; Nitric Oxide; Nitroprusside; Nitroso Compounds; Rats; Sulfhydryl Compounds | 1980 |
Increased concentrations of cyclic GMP in fetal liver cells stimulated by erythropoietin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; DNA; Erythropoietin; Heme; Liver; Rats | 1981 |
Role of erythropoietin and cyclic nucleotides in erythroid cell proliferation in fetal liver.
Topics: Animals; Cell Cycle; Cyclic AMP; Cyclic GMP; DNA; Erythropoiesis; Erythropoietin; Fetus; Heme; Liver; Rats; Rats, Inbred Strains | 1980 |
Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase.
Topics: Amino Acid Sequence; Animals; Cyclic GMP; Enzyme Activation; Glutathione; Guanosine Triphosphate; Guanylate Cyclase; Heme; Histidine; Molecular Sequence Data; Mutation; Nitric Oxide; Nitroprusside; Nitroso Compounds; S-Nitrosoglutathione; Spectrophotometry | 1994 |
[Soluble platelet guanylate cyclase: significance of heme in regulating enzymatic activity and the role of the enzyme in platelet aggregation].
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Humans; In Vitro Techniques; Oxidation-Reduction; Platelet Aggregation; Rats; Solubility | 1994 |
Nitric oxide formation during light-induced decomposition of phenyl N-tert-butylnitrone.
Topics: Animals; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Guanylate Cyclase; Heme; Hemeproteins; Light; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes; Nitric Oxide; Nitrites; Nitrogen Oxides; Nitroprusside; Photolysis; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spin Labels | 1993 |
Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide.
Topics: Animals; Binding Sites; Cattle; Cyclic GMP; Enzyme Activation; Flow Injection Analysis; Guanylate Cyclase; Heme; Kinetics; Models, Chemical; Molecular Weight; Nitric Oxide; Signal Transduction; Solubility; Spectrophotometry | 1996 |
Carbon monoxide: an endogenous modulator of the nitric oxide-cyclic GMP signaling system.
Topics: Animals; Animals, Newborn; Carbon Monoxide; Cells, Cultured; Cerebellum; Cyclic GMP; Drug Synergism; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Rats; Signal Transduction | 1996 |
Effects of halothane and isoflurane on carbon monoxide-induced relaxations in the rat aorta.
Topics: Anesthetics, Inhalation; Animals; Aorta, Thoracic; Binding Sites; Carbon Dioxide; Cyclic GMP; Drug Interactions; Endothelium, Vascular; Halothane; Heme; In Vitro Techniques; Isoflurane; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 1996 |
The regulation of heme turnover and carbon monoxide biosynthesis in cultured primary rat olfactory receptor neurons.
Topics: Animals; Carbon Monoxide; Cell Differentiation; Cells, Cultured; Cyclic GMP; Heme; Heme Oxygenase (Decyclizing); Nerve Tissue; Neurons, Afferent; Olfactory Pathways; Rats; Sensory Receptor Cells | 1996 |
Purification of bovine soluble guanylate cyclase and ADP-ribosylation on its small subunit by bacterial toxins.
Topics: Adenosine Diphosphate; Adenosine Diphosphate Ribose; Animals; Bacterial Toxins; Cattle; Cyclic GMP; Guanosine Triphosphate; Guanylate Cyclase; Heme; Kinetics; Lung; Macromolecular Substances; Manganese; NAD; Nitric Oxide; Sensitivity and Specificity; Solubility | 1997 |
Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: role for nucleotide cyclases as oxygen sensors.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Biological Transport; Cell Line; Cyclic AMP; Cyclic GMP; Down-Regulation; Epithelial Cells; Guanylate Cyclase; Heme; Humans; Hypoxia; Intestinal Mucosa; Nucleotides, Cyclic; Oxygen; Water-Electrolyte Balance | 1998 |
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.
Topics: Animals; Cattle; Cells, Cultured; Cerebellum; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Heme; Humans; In Vitro Techniques; Kinetics; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Oxazines; Rabbits; Solubility; Spectrophotometry; Structure-Activity Relationship; Swine; Umbilical Veins | 1998 |
The deactivation of soluble guanylyl cyclase by redox-active agents.
Topics: Animals; Cattle; Cyclic GMP; Enzyme Activation; Ferricyanides; Guanylate Cyclase; Heme; Kinetics; Methylene Blue; Nitrates; Nitric Oxide; Oxidation-Reduction; Solubility | 1998 |
Carbon monoxide and cerebral microvascular tone in newborn pigs.
Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Carbon Monoxide; Cerebral Arteries; Cerebrovascular Circulation; Chromium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Heme; Heme Oxygenase (Decyclizing); Lysine; Mesoporphyrins; Microcirculation; Nitroarginine; Pia Mater; Potassium Channels; Swine; Tetraethylammonium; Vasodilation; Vasodilator Agents | 1999 |
NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO.
Topics: Animals; Cattle; Colforsin; Cyclic GMP; Electron Transport; Enzyme Activation; Enzyme Inhibitors; Ferricyanides; Flavoproteins; Glutathione; Guanylate Cyclase; Heme; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADP; Nitric Oxide; Oxadiazoles; Oxidation-Reduction; Penicillamine; Pentose Phosphate Pathway; Pulmonary Artery; Quinoxalines; Reactive Oxygen Species; Sulfhydryl Compounds | 1999 |
Control of nitric oxide dynamics by guanylate cyclase in its activated state.
Topics: Allosteric Site; Animals; Catalysis; Cattle; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Hydrogen-Ion Concentration; Kinetics; Ligands; Lung; Nitric Oxide; Oxygen; Protein Binding; Protein Conformation; Recombination, Genetic; Spectrophotometry | 2001 |
On the activation of soluble guanylyl cyclase by nitric oxide.
Topics: Binding Sites; Cyclic GMP; Guanylate Cyclase; Heme; Humans; Kinetics; Models, Chemical; Nitric Oxide; Protein Binding; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Time Factors | 2002 |
Role of the preoptic carbon monoxide pathway in endotoxin fever in rats.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Endotoxemia; Enzyme Inhibitors; Fever; Heme; Heme Oxygenase (Decyclizing); Injections, Intraventricular; Lipopolysaccharides; Lysine; Male; Methylene Blue; Microinjections; Preoptic Area; Rats; Rats, Wistar; Vasodilator Agents | 2002 |
Functional expression of human heme oxygenase-1 (HO-1) driven by HO-1 promoter in vitro and in vivo.
Topics: Animals; Animals, Newborn; Blotting, Western; Carbon Monoxide; Cells, Cultured; Cyclic GMP; Dinoprostone; Endothelium, Vascular; Gene Expression; Gene Expression Regulation, Enzymologic; Genetic Vectors; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Lung; Membrane Proteins; Mice; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Retroviridae; RNA, Messenger | 2002 |
Cerebrovasodilatory contribution of endogenous carbon monoxide during seizures in newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Bicuculline; Carbon Monoxide; Cerebral Arteries; Cerebrovascular Circulation; Convulsants; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; GABA Antagonists; Glutamates; Heme; Heme Oxygenase (Decyclizing); Membrane Potentials; Mesoporphyrins; Metalloporphyrins; Nerve Tissue Proteins; Neurons; Pia Mater; Protoporphyrins; Seizures; Status Epilepticus; Swine; Vasodilation | 2002 |
Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells.
Topics: Animals; Cyclic GMP; Endothelium, Vascular; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Pulmonary Circulation; Rats; Recombinant Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2002 |
Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization.
Topics: Animals; Biliverdine; Calcium Signaling; Carbon Monoxide; Cell Membrane; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heme; Heme Oxygenase (Decyclizing); Large-Conductance Calcium-Activated Potassium Channels; Lysine; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Ryanodine; Vascular Resistance; Vasodilation | 2003 |
Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.
Topics: Animals; Antioxidants; Azoles; Catalase; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Isoindoles; Lung; Maleates; Membrane Proteins; Nitric Oxide Synthase; Nitroarginine; Organoselenium Compounds; Oxidants; Rats; Reactive Oxygen Species; Transfection | 2003 |
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system.
Topics: Animals; Calcitonin; Cyclic GMP; Cytosol; Dimerization; Dogs; Dose-Response Relationship, Drug; Glutathione; Heme; Kinetics; Male; Models, Chemical; Nitric Oxide; Nitrogen; Oxidation-Reduction; Oxygen; Peptides; Protein Binding | 2003 |
Preparation of heme-free soluble guanylate cyclase.
Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc | 2003 |
Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues.
Topics: Animals; Cyclic GMP; Electron Spin Resonance Spectroscopy; Female; Heme; Luminescent Measurements; Myocardial Ischemia; Nitric Oxide; Rats; Rats, Sprague-Dawley; Signal Transduction | 2004 |
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.
Topics: Animals; Bacteria; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Aggregation; Cyclic GMP; Feeding Behavior; Food; Gases; Guanylate Cyclase; Heme; Hyperoxia; Ion Channels; Mutation; Neurons, Afferent; Nitric Oxide; Oxygen; Protein Binding; Protein Structure, Tertiary; Social Behavior | 2004 |
Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells.
Topics: Animals; Cells, Cultured; Cyclic GMP; Cysteine; Dithiothreitol; Endothelium, Vascular; Enzyme Activation; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Free Radicals; Genes, Reporter; Green Fluorescent Proteins; Guanylate Cyclase; Heme; Microscopy, Fluorescence; Nitric Oxide; Nitroso Compounds; Peptides; Protein Conformation; Proteins; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Sheep; Signal Transduction; Soluble Guanylyl Cyclase; Spectrometry, Fluorescence; Sulfhydryl Compounds | 2004 |
NO activation of guanylyl cyclase.
Topics: Catalysis; Cyclic GMP; Diphosphates; Enzyme Activation; Ferrous Compounds; Guanylate Cyclase; Heme; Histidine; Ligands; Magnesium; Models, Chemical; Nitric Oxide; Protein Binding; Signal Transduction; Spectrophotometry, Ultraviolet | 2004 |
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection | 2005 |
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.
Topics: Adenosine Triphosphate; Allosteric Regulation; Cell Hypoxia; Cyclic GMP; Erythrocytes; Heme; Hemoglobins; Humans; Mitochondria; Mutation; Nitric Oxide; Nitrite Reductases; Nitrites; Oxidation-Reduction; Oxygen; Respiration; Vasodilation | 2006 |
Identification of residues crucially involved in soluble guanylate cyclase activation.
Topics: Animals; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Models, Molecular; Protein Structure, Tertiary; Rats; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity; Thermoanaerobacter | 2006 |
Role of the locus coeruleus carbon monoxide pathway in endotoxin fever in rats.
Topics: Animals; Body Temperature; Carbon Monoxide; Central Nervous System; Cyclic GMP; Enzyme Inhibitors; Fever; Guanylate Cyclase; Heme; Heme Oxygenase (Decyclizing); Lipopolysaccharides; Locus Coeruleus; Lysine; Male; Rats; Rats, Wistar; Signal Transduction | 2007 |
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
Topics: Animals; Benzoates; Blood Pressure; Blood Vessels; Cell Culture Techniques; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; Heme; Oxidation-Reduction; Oxidative Stress; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Swine; Vasodilation | 2006 |
Role of the peripheral heme oxygenase-carbon monoxide pathway on the nociceptive response of rats to the formalin test: evidence for a cGMP signaling pathway.
Topics: Animals; Biliverdine; Carbon Monoxide; Cyclic GMP; Deferoxamine; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Iron Chelating Agents; Lysine; Male; Pain; Pain Measurement; Rats; Rats, Wistar; Signal Transduction | 2007 |
Critical role of the heme axial ligand, Met95, in locking catalysis of the phosphodiesterase from Escherichia coli (Ec DOS) toward Cyclic diGMP.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Carbon Monoxide; Catalysis; Cyclic GMP; Escherichia coli; Heme; Iron; Ligands; Methionine; Models, Molecular; Nitric Oxide; Oxygen; Phosphoric Diester Hydrolases; Protein Binding; Protein Conformation | 2007 |
Role of the spinal cord heme oxygenase-carbon monoxide-cGMP pathway in the nociceptive response of rats.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Lysine; Male; Methylene Blue; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2008 |
Probing the presence of the ligand-binding haem in cellular nitric oxide receptors.
Topics: Animals; Benzoates; Binding Sites; Blood Platelets; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; Drug Delivery Systems; Guanylate Cyclase; Heme; Ligands; Nitric Oxide; Oxidation-Reduction; Phosphorylation; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Role of locus coeruleus heme oxygenase-carbon monoxide-cGMP pathway during hypothermic response to restraint.
Topics: Animals; Behavior, Animal; Body Temperature; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Hypothermia; Locus Coeruleus; Lysine; Male; Microinjections; Rats; Rats, Wistar; Restraint, Physical | 2008 |
Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.
Topics: Apoptosis; Blotting, Western; Breast; Breast Neoplasms; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media, Serum-Free; Cyclic GMP; eIF-2 Kinase; Enzyme Activation; Eukaryotic Initiation Factor-2; Female; Free Radical Scavengers; Genes, ras; Heme; Humans; Hydrogen Peroxide; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Oxidants; Oxidative Stress; Phosphorylation; Protein Biosynthesis; RNA, Small Interfering | 2008 |
Arg97 at the heme-distal side of the isolated heme-bound PAS domain of a heme-based oxygen sensor from Escherichia coli (Ec DOS) plays critical roles in autoxidation and binding to gases, particularly O2.
Topics: Arginine; Carbon Monoxide; Carrier Proteins; Crystallography, X-Ray; Cyclic GMP; Escherichia coli Proteins; Ferric Compounds; Ferrous Compounds; Heme; Iron; Models, Molecular; Mutagenesis, Site-Directed; Nitric Oxide; Oxidation-Reduction; Oxygen; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship | 2008 |
O2- and NO-sensing mechanism through the DevSR two-component system in Mycobacterium smegmatis.
Topics: Amino Acid Sequence; Bacterial Proteins; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Ferrous Compounds; Heme; Models, Molecular; Molecular Sequence Data; Mycobacterium smegmatis; Nitric Oxide; Oxygen; Phosphorylation; Protamine Kinase; Protein Structure, Tertiary; Sequence Alignment; Signal Transduction; Ubiquinone; Vitamin K 2 | 2008 |
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Male; Models, Molecular; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; ortho-Aminobenzoates; Oxidants; Oxidative Stress; Protein Conformation; Protein Structure, Tertiary; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Sulfonamides; Transfection; Vasodilator Agents | 2008 |
Ligand binding to the Fe(III)-protoporphyrin IX complex of phosphodiesterase from Escherichia coli (Ec DOS) markedly enhances catalysis of cyclic di-GMP: roles of Met95, Arg97, and Phe113 of the putative heme distal side in catalytic regulation and ligand
Topics: Animals; Arginine; Catalysis; Cattle; Cyclic GMP; Escherichia coli Proteins; Ferric Compounds; Heme; Ligands; Methionine; Mutagenesis, Site-Directed; Phenylalanine; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Tertiary; Protoporphyrins | 2008 |
Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation.
Topics: Blood Vessels; Cell Line; Cyclic GMP; Guanylate Cyclase; Heme; Humans; Nitric Oxide; Oxidation-Reduction; Proteasome Endopeptidase Complex; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Ubiquitination; Vasodilator Agents | 2009 |
Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats.
Topics: Animals; Arginine; Arterioles; Blood Pressure; Calcium; Cyclic GMP; Desoxycorticosterone; Dinoprost; Endothelin-1; Heme; Heme Oxygenase (Decyclizing); Hypertension; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Male; Mesenteric Arteries; Mineralocorticoids; NF-kappa B; Organometallic Compounds; Oxidative Stress; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Sodium Chloride, Dietary; Type C Phospholipases; Up-Regulation | 2010 |
Cyclic di-GMP activation of polynucleotide phosphorylase signal-dependent RNA processing.
Topics: Cyclic GMP; Endoribonucleases; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Heme; Macromolecular Substances; Oxygen; Phosphopyruvate Hydratase; Polyribonucleotide Nucleotidyltransferase; RNA; Second Messenger Systems | 2011 |
Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Benzoates; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Cysteine; Enzyme Activation; Enzyme Activators; Fluorescence; Fluorescent Dyes; Guanylate Cyclase; Heme; Humans; Molecular Sequence Data; Mutation; Nitric Oxide; Oxadiazoles; Oxazines; Oxidation-Reduction; Protein Engineering; Receptors, Cytoplasmic and Nuclear; Rotenone; Signal Transduction; Soluble Guanylyl Cyclase; Spectrometry, Fluorescence | 2011 |
Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization.
Topics: Animals; Cell Line; Cyclic GMP; Guanylate Cyclase; Heme; Humans; Models, Biological; Nitric Oxide; Protein Binding; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Spodoptera | 2011 |
Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation.
Topics: Animals; Benzoates; Biphenyl Compounds; Cardiomegaly; Caveolin 3; Cyclic GMP; Disease Models, Animal; Down-Regulation; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Hydrocarbons, Fluorinated; Hydrolysis; Membrane Microdomains; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Nitric Oxide; Oxidation-Reduction; Protein Transport; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase | 2012 |
Hydrogen sulfide stimulates the catalytic activity of a heme-regulated phosphodiesterase from Escherichia coli (Ec DOS).
Topics: Catalysis; Cyclic GMP; Escherichia coli; Heme; Hydrogen Sulfide; Mutagenesis, Site-Directed; Phosphoric Diester Hydrolases; Spectrophotometry, Ultraviolet | 2012 |
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.
Topics: Animals; Aorta; Biopterins; Cardiovascular Diseases; Cells, Cultured; Cyclic GMP; Endothelial Cells; Fibroblasts; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Pterins; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Swine | 2012 |
Nitric oxide- and heme-independent activation of soluble guanylate cyclase attenuates peroxynitrite-induced endothelial dysfunction in rat aorta.
Topics: Animals; Aorta, Thoracic; Benzoates; Cyclic GMP; DNA Breaks; Endothelium, Vascular; Guanylate Cyclase; Heme; In Vitro Techniques; Male; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilation | 2013 |
Interactions of soluble guanylate cyclase with a P-site inhibitor: effects of gaseous heme ligands, azide, and allosteric activators on the binding of 2'-deoxy-3'-GMP.
Topics: Allosteric Regulation; Azides; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heme; Ligands; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2012 |
An HD-GYP cyclic di-guanosine monophosphate phosphodiesterase with a non-heme diiron-carboxylate active site.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Bacterial Proteins; Catalytic Domain; Cyclic GMP; Heme; Iron; Models, Molecular; Protein Structure, Tertiary; Vibrio cholerae | 2013 |
A structural basis for the regulation of an H-NOX-associated cyclic-di-GMP synthase/phosphodiesterase enzyme by nitric oxide-bound H-NOX.
Topics: Bacterial Proteins; Biofilms; Cyclic GMP; Escherichia coli Proteins; Heme; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Mutant Proteins; Nitric Oxide; Oxygen; Phosphoric Diester Hydrolases; Phosphorus-Oxygen Lyases; Shewanella | 2014 |
Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension.
Topics: Adiponectin; Aldosterone; Animals; Antioxidants; Arginine; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomyopathies; Cardiotonic Agents; Chemokine CCL2; Chemokine CCL3; Cyclic GMP; Dinoprost; Endothelin-1; Enzyme Induction; Extracellular Matrix Proteins; Heart Failure; Heme; Heme Oxygenase (Decyclizing); Hypertension; Interleukin-1beta; Interleukin-6; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent.
Topics: Acute Pain; Animals; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Lysine; Male; Nociceptive Pain; Oxadiazoles; Pain Measurement; Rats, Wistar; Signal Transduction; Stress Disorders, Traumatic, Acute | 2014 |
Chronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats.
Topics: Animals; Blood Pressure; Cyclic GMP; Glomerular Filtration Rate; Guanylate Cyclase; Heme; Kidney; Male; Nitric Oxide; Rats; Rats, Inbred Dahl; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2015 |
Oxygen and Bis(3',5')-cyclic Dimeric Guanosine Monophosphate Binding Control Oligomerization State Equilibria of Diguanylate Cyclase-Containing Globin Coupled Sensors.
Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Biocatalysis; Biofilms; Bordetella pertussis; Cyclic GMP; Escherichia coli Proteins; Globins; Heme; Hemeproteins; Kinetics; Models, Molecular; Mutation; Oxygen; Pectobacterium carotovorum; Phosphorus-Oxygen Lyases; Protein Binding; Protein Domains; Protein Multimerization; Sequence Homology, Amino Acid | 2016 |
Erectile Dysfunction in Heme-Deficient Nitric Oxide-Unresponsive Soluble Guanylate Cyclase Knock-In Mice.
Topics: Animals; Cyclic GMP; Disease Models, Animal; Erectile Dysfunction; Guanylate Cyclase; Heme; Humans; Male; Mice; Nitric Oxide; Penile Erection; Penis; Soluble Guanylyl Cyclase | 2017 |
The NO-heme signaling hypothesis.
Topics: Animals; Cyclic GMP; Endothelium-Dependent Relaxing Factors; Enzyme Activation; Gene Expression; Heme; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitrosation; Protein Processing, Post-Translational; Signal Transduction; Soluble Guanylyl Cyclase; Vasodilation | 2017 |
NosP Signaling Modulates the NO/H-NOX-Mediated Multicomponent c-Di-GMP Network and Biofilm Formation in
Topics: Bacterial Proteins; Biofilms; Cyclic GMP; Gene Expression Regulation, Bacterial; Heme; Nitric Oxide; Shewanella; Signal Transduction | 2019 |
Inflammation in the Human Periodontium Induces Downregulation of the α
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cyclic GMP; Gene Expression Regulation; Heme; Humans; Inflammation; Iron; Nitric Oxide; Osteoclasts; Oxidation-Reduction; Periodontal Ligament; Periodontium; Soluble Guanylyl Cyclase | 2021 |
Inactivation of soluble guanylyl cyclase in living cells proceeds without loss of haem and involves heterodimer dissociation as a common step.
Topics: Cyclic GMP; Guanylate Cyclase; HEK293 Cells; Heme; Humans; Nitric Oxide; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2022 |
Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein.
Topics: Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Binding Sites; Cyclic GMP; Escherichia coli; Escherichia coli Proteins; Gene Expression; Heme; Hemeproteins; Kinetics; Models, Molecular; Oxygen; Paenibacillus; Phosphoric Diester Hydrolases; Phosphorus-Oxygen Lyases; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Static Electricity; Structure-Activity Relationship; Substrate Specificity | 2021 |
NO rapidly mobilizes cellular heme to trigger assembly of its own receptor.
Topics: Animals; Calcium; Cyclic GMP; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanylate Cyclase; Heme; HSP90 Heat-Shock Proteins; Humans; Mice; Models, Biological; Nitric Oxide; Protein Binding; Protein Multimerization; Protein Transport; Receptors, Cell Surface; Signal Transduction; Soluble Guanylyl Cyclase | 2022 |
The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms.
Topics: Animals; Cyclic GMP; Guanylate Cyclase; Heme; Hippocampus; Male; Mice; Neuronal Plasticity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Soluble Guanylyl Cyclase; Vasodilator Agents | 2022 |
The differential roles of the two NO-GC isoforms in adjusting airway reactivity.
Topics: Animals; Bronchoconstrictor Agents; Cyclic GMP; Guanylate Cyclase; Heme; Methacholine Chloride; Mice; Mice, Knockout; Nitric Oxide; Ovalbumin; Protein Isoforms; Soluble Guanylyl Cyclase; Vasodilator Agents | 2022 |
Dental Pulp Inflammation Initiates the Occurrence of Mast Cells Expressing the α
Topics: Cyclic GMP; Dental Pulp; Guanylate Cyclase; Heme; Humans; Inflammation; Nitric Oxide; Soluble Guanylyl Cyclase | 2023 |
BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Complex.
Topics: Animals; Cyclic GMP; Guanylate Cyclase; Heat-Shock Proteins; HEK293 Cells; Heme; Humans; Nitric Oxide; Rats; Signal Transduction; Soluble Guanylyl Cyclase | 2023 |
NO binds to the distal site of haem in the fully activated soluble guanylate cyclase.
Topics: Cyclic GMP; Guanylate Cyclase; Heme; Nitric Oxide; Soluble Guanylyl Cyclase | 2023 |
The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats.
Topics: Animals; Clinical Trials, Phase II as Topic; Cyclic GMP; Glycated Hemoglobin; Heme; Kidney; Obesity; Proteinuria; Rats; Renal Insufficiency, Chronic | 2023 |