Page last updated: 2024-08-23

heme and cyclic gmp

heme has been researched along with cyclic gmp in 94 studies

Research

Studies (94)

TimeframeStudies, this research(%)All Research%
pre-199014 (14.89)18.7374
1990's15 (15.96)18.2507
2000's34 (36.17)29.6817
2010's19 (20.21)24.3611
2020's12 (12.77)2.80

Authors

AuthorsStudies
Arnold, WP; Braughler, JM; Mittal, CK; Murad, F1
Stewart, PR1
Ernst, V; Fifer, MA; Levin, DH; London, LM; Ranu, RS1
Bomboy, JD; Graber, SE; Krantz, SB; Salmon, WD1
Ignarro, LJ2
Ignarro, LJ; Wood, KS1
Schini, VB; Vanhoutte, PM1
Buga, GM; Byrns, RE; Ignarro, LJ; Wood, KS1
Carrillo, M; Graber, SE; Krantz, SB1
Edwards, PM; Frankena, H; Schotman, P; Schrama, LH1
Craven, PA; Derubertis, FR; Saito, R1
Briggs, RG; Derubertis, FR1
Hyman, AL; Ignarro, LJ; Kadowitz, PJ; McNamara, DB1
George, WJ; White, LE1
Fisher, JW; George, WJ; White, L1
Böhme, E; Foerster, J; Harteneck, C; Humbert, P; Koesling, D; Malkewitz, J; Schultz, G; Wedel, B1
Severina, IS1
Chamulitrat, W; Cutler, RG; Jordan, SJ; Mason, RP; Saito, K1
Marletta, MA; Stone, JR1
Cheng, J; Ingi, T; Ronnett, GV1
Bina, S; Hart, JL; Jing, M; Muldoon, SM; Verma, A1
Chiang, G; Ingi, T; Ronnett, GV1
Imai, Y; Kitagawa, T; Tomita, T; Tsuyama, S1
Awtrey, CS; Colgan, SP; Lisco, SJ; Taylor, CT1
Axelsson, O; Bang, L; Busse, R; Drejer, J; Moldt, P; Mülsch, A; Nielsen-Kudsk, JE; Olesen, SP1
Burstyn, JN; Dierks, EA1
Fedinec, AL; Johnson, RA; Leffler, CW; Nasjletti, A; Walker, N; Yu, C1
Gupte, SA; Phillibert, D; Rupawalla, T; Wolin, MS1
Bouzhir, L; Liebl, U; Martin, JL; Négrerie, M1
Bellamy, TC; Garthwaite, J; Wood, J1
Branco, LG; Steiner, AA1
Abraham, NG; Balazy, M; Jiang, H; Quan, S; Schwartzman, ML; Shenouda, S; Shibahara, I; Shinohara, K; Yang, L1
Bada, HS; Daley, ML; Korones, SB; Leffler, CW; Parfenova, H; Pourcyrous, M1
Abraham, NG; Burke-Wolin, T; Goodman, AI; Mieyal, PA; Mingone, CJ; Nasjletti, A; Quan, S; Wolin, MS; Yang, L1
Naik, JS; Walker, BR1
Abraham, NG; Gupte, SA; Mingone, CJ; Quan, S; Wolin, MS1
Bartberger, MD; Espey, MG; Feelisch, M; Ford, E; Fukuto, JM; Kass, DA; Katori, T; Miranda, KM; Paolocci, N; Thomas, DD; Wink, DA1
Schmidt, P; Schramm, M; Schröder, H; Stasch, JP1
Samouilov, A; Tiravanti, E; Zweier, JL1
Bargmann, CI; Chang, AJ; Chang, JS; Ellis, RE; Gray, JM; Karow, DS; Lu, H; Marletta, MA1
Leelavanichkul, K; Pitt, BR; St Croix, CM; Stitt, MS; Wasserloos, KJ; Watkins, SC1
Koesling, D; Russwurm, M2
Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F1
Chacko, BK; Crawford, JH; Darley-Usmar, VM; Gladwin, MT; Ho, C; Huang, Z; Isbell, TS; Kerby, JD; Kraus, D; Lang, JD; Patel, RP; Schechter, AN; Shiva, S1
Cary, SP; Derbyshire, ER; Marletta, MA; Winger, JA1
Rothkegel, C; Schmidt, HH; Schmidt, PM; Schröder, H; Stasch, JP; Stoll, F1
Almeida, MC; Branco, LG; Ravanelli, MI1
Deile, M; H S, AK; Kemp-Harper, B; Knorr, A; Lapp, H; Meurer, S; Müller, H; Müller-Esterl, W; Nedvetskaya, TY; Nedvetsky, PI; Rothkegel, C; Schmidt, HH; Schmidt, PM; Stasch, JP; Taye, A; Tersteegen, A; Turgay, Y1
Branco, LG; Nascimento, CG2
Boerrigter, G; Burnett, JC1
Shimizu, T; Takahashi, H; Tanaka, A1
Garthwaite, J; Mo, E; Roy, B; Vernon, J1
Branco, LG; Ravanelli, MI1
Chaudhuri, G; Fukuto, JM; Pervin, S; Singh, R; Tran, AH; Zekavati, S1
Tsoukias, NM1
Araki, Y; Igarashi, J; Ishitsuka, Y; Ito, O; Shimizu, T; Tanaka, A1
Baik, HS; Cho, HJ; Cho, HY; Eom, CY; Kang, BS; Kim, YM; Ko, IJ; Lee, JM; Oh, JH; Oh, JI; Park, SW1
Dalkas, G; Kotanidou, A; Papapetropoulos, A; Pyriochou, A; Roussos, C; Spyroulias, G; van Eickels, M; Zhou, Z1
Shimizu, T; Tanaka, A1
Beckhaus, T; Gegenbauer, K; Geschka, S; Karas, M; Matt, S; Meurer, S; Müller-Esterl, W; Opitz, N; Pabst, T; Pioch, S; Schmidt, HH; Schmidt, PM; Stasch, JP; Wagner, K1
Jadhav, A; Ndisang, JF1
Gilles-Gonzalez, MA; Gonzalez, G; Tuckerman, JR1
Ducsay, CA; Myers, DA1
Hoffmann, C; Hoffmann, LS; Keim, Y; Schmidt, HH; Schmidt, PM; Stasch, JP1
Berka, V; Martin, E; Sharina, I; Tsai, AL1
Bedja, D; Danner, T; Friebe, A; Jasmin, JF; Kass, DA; Koitabashi, N; Lisanti, MP; Liu, Y; Takimoto, E; Tsai, EJ1
Igarashi, J; Sekimoto, M; Shimizu, T; Takahashi, H; Tanaka, A; Tanaka, M1
Gorren, AC; Kolesnik, B; Mayer, B; Neubauer, A; Schmidt, K; Stasch, JP; Werner, ER1
Barnucz, E; Hegedüs, P; Hirschberg, K; Karck, M; Korkmaz, S; Li, S; Loganathan, S; Mikles, B; Páli, S; Radovits, T; Szabó, G; Weymann, A1
Hori, H; Makino, R; Shiro, Y; Yazawa, S1
Klose, KE; Kurtz, DM; Miner, KD1
Boon, EM; Lahiri, T; Luan, B; Raleigh, DP1
Chibbar, R; Lane, N; Ndisang, JF1
Branco, LG; Carvalho-Costa, PG; Leite-Panissi, CR1
Hocher, B; Hoffmann, LS; Kretschmer, A; Lawrenz, B; Stasch, JP1
Burns, JL; Deer, DD; Dvorak, D; Joynt, SC; Rivera, S; Weinert, EE1
Boydens, C; Brouckaert, P; Buys, ES; Decaluwé, K; Pauwels, B; Thoonen, R; Van de Voorde, J1
Kleschyov, AL1
Arora, DP; Bacon, B; Binnenkade, L; Boon, EM; Brutinel, ED; Drescher, K; Gralnick, JA; Hartmann, R; Hossain, S; Kotloski, NJ; Muralidharan, S; Nisbett, LM; Thormann, KM1
Bloch, W; Deschner, J; Friebe, A; Galler, K; Gölz, L; Kämmerer, PW; Korkmaz, Y; Puladi, B; Schröder, A; Sparwasser, T1
Dai, Y; Stuehr, DJ2
Armache, JP; Das, S; Kincaid, JR; Liu, Y; Patterson, DC; Weinert, EE; Yennawar, NH1
Dai, Y; Faul, EM; Ghosh, A; Stuehr, DJ1
Dietz, L; Gerisch, M; Hüser, J; Janssen, W; Mulder-Jongen, DAJ; Nelissen, E; Possemis, N; Prickaerts, J; Sandner, P; Schepers, M; Van Goethem, NP; Vanmierlo, T1
Gnipp, S; Koesling, D; Mergia, E; Peters, M; Puschkarow, M; Verheyen, M1
Bloch, W; Demirbas, A; Deschner, J; Korkmaz, Y; Plomann, M; Puladi, B1
Chen, L; Kang, Y; Liu, R1
Benardeau, A; Eitner, F; Ellinger-Ziegelbauer, H; Freyberger, A; Geiss, V; Hagelschuer, I; Hahn, MG; Hartmann, E; Hueser, J; Kraehling, JR; Mathar, I; Pavkovic, M; Popp, L; Sandner, P; Schomber, T; Siudak, K; Vienenkoetter, J1
Hoque, NJ; Weinert, EE1
Bronckaers, A; Foulquier, S; Nelissen, E; Ponsaerts, L; Prickaerts, J; Sandner, P; Schepers, M; Vanmierlo, T1

Reviews

11 review(s) available for heme and cyclic gmp

ArticleYear
Properties and regulation of guanylate cyclase and some proposed functions for cyclic GMP.
    Advances in cyclic nucleotide research, 1979, Volume: 11

    Topics: Animals; Azides; Cyclic GMP; Dehydroascorbic Acid; Detergents; Enterotoxins; Enzyme Activation; Escherichia coli; Guanylate Cyclase; Heme; Hormones; Intestinal Mucosa; Kinetics; Molecular Weight; Muscle, Smooth; Nitric Oxide; Oxidation-Reduction; Subcellular Fractions; Sulfhydryl Compounds

1979
Analytical methods for yeasts.
    Methods in cell biology, 1975, Volume: 12

    Topics: Adenine Nucleotides; Amino Acids; Carbohydrates; Cell Fractionation; Chitin; Cyclic AMP; Cyclic GMP; Cytochromes; DNA; Fungal Proteins; Glycogen; Glycoproteins; Heme; Immunoassay; Lipids; Mannans; Mitochondria; Polysaccharides; Porphyrins; RNA; Subcellular Fractions; Yeasts

1975
Signal transduction mechanisms involving nitric oxide.
    Biochemical pharmacology, 1991, Feb-15, Volume: 41, Issue:4

    Topics: Animals; Cell Communication; Cyclic GMP; Heme; Humans; Nitric Oxide; Signal Transduction

1991
Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: a unique transduction mechanism for transcellular signaling.
    Pharmacology & toxicology, 1990, Volume: 67, Issue:1

    Topics: Animals; Cell Communication; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Nitric Oxide; Signal Transduction

1990
Guanylyl cyclase: NO hits its target.
    Biochemical Society symposium, 2004, Issue:71

    Topics: Animals; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Humans; Isoenzymes; Models, Chemical; Nitric Oxide; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tissue Distribution

2004
Nitric oxide signaling: no longer simply on or off.
    Trends in biochemical sciences, 2006, Volume: 31, Issue:4

    Topics: Animals; Cyclic GMP; Guanylate Cyclase; Heme; Humans; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Signal Transduction

2006
Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease.
    Cardiovascular drug reviews, 2007,Spring, Volume: 25, Issue:1

    Topics: Animals; Antihypertensive Agents; Benzoates; Cardiovascular Diseases; Cell Adhesion; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heart Failure; Heme; Humans; Hypertension; Hypertension, Pulmonary; Inflammation; Leukocytes; Nitric Oxide; Platelet Aggregation; Pyrazoles; Pyridines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilator Agents

2007
Nitric oxide bioavailability in the microcirculation: insights from mathematical models.
    Microcirculation (New York, N.Y. : 1994), 2008, Volume: 15, Issue:8

    Topics: Animals; Cyclic GMP; Cysteine; Diffusion; Endothelium, Vascular; Erythrocytes; Guanylate Cyclase; Heme; Hemoglobins; Humans; Microcirculation; Microvessels; Models, Cardiovascular; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Sulfhydryl Compounds; Vasodilation

2008
eNOS activation and NO function: differential control of steroidogenesis by nitric oxide and its adaptation with hypoxia.
    The Journal of endocrinology, 2011, Volume: 210, Issue:3

    Topics: Adrenal Glands; Animals; Cyclic GMP; Cysteine; Enzyme Activation; Female; Guanylate Cyclase; Heme; Humans; Hypoxia; Male; Models, Biological; Nitric Oxide; Nitric Oxide Synthase Type III; Ovary; Pregnancy; Protein Processing, Post-Translational; Steroids; Testis; Tyrosine

2011
Control of bacterial second messenger signaling and motility by heme-based direct oxygen-sensing proteins.
    Current opinion in microbiology, 2023, Volume: 76

    Topics: Bacteria; Bacterial Proteins; Biofilms; Cyclic GMP; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Heme; Hemeproteins; Oxygen; Second Messenger Systems

2023
Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?
    Pharmacological research, 2023, Volume: 197

    Topics: Cognitive Dysfunction; Cyclic GMP; Heme; Humans; Inflammation; Soluble Guanylyl Cyclase; Vascular Diseases

2023

Other Studies

83 other study(ies) available for heme and cyclic gmp

ArticleYear
Association of a cyclic AMP-dependent protein kinase with a purified translational inhibitor isolated from hemin-deficient rabbit reticulocyte lysates.
    Proceedings of the National Academy of Sciences of the United States of America, 1975, Volume: 72, Issue:12

    Topics: Animals; Binding Sites; Blood Proteins; Cyclic AMP; Cyclic GMP; Enzyme Activation; Heme; Hemin; Isoenzymes; Kinetics; Macromolecular Substances; Protein Binding; Protein Biosynthesis; Protein Kinases; Rabbits; Reticulocytes

1975
Effect of erythropoietin preparations on cyclic AMP and cyclic GMP levels in rat fetal liver cell cultures.
    The Journal of laboratory and clinical medicine, 1977, Volume: 90, Issue:1

    Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; Erythropoietin; Gestational Age; Heme; Liver; Phosphodiesterase Inhibitors; Rats; Xanthines

1977
Hepatic cyclic GMP formation is regulated by similar factors that modulate activation of purified hepatic soluble guanylate cyclase.
    The Journal of biological chemistry, 1987, Apr-15, Volume: 262, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Acetaminophen; Acetylcysteine; Animals; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Heme; Liver; Methylnitronitrosoguanidine; Mice; Nitroglycerin; Penicillamine; Phenobarbital; Phenylhydrazines; Potassium Cyanide; Probenecid; Protoporphyrins; Purinones; S-Nitroso-N-Acetylpenicillamine

1987
SIN-1 stimulates the production of cyclic GMP but not cyclic AMP in porcine aortic endothelial cells.
    Journal of cardiovascular pharmacology, 1989, Volume: 14 Suppl 11

    Topics: Animals; Aorta, Thoracic; Cells, Cultured; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Heme; Methylene Blue; Molsidomine; Rodentia; Vasodilator Agents

1989
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.
    Circulation research, 1987, Volume: 61, Issue:6

    Topics: Acetylcholine; Animals; Biological Products; Bradykinin; Carbon Monoxide; Cattle; Cyclic GMP; Endothelium, Vascular; Free Radicals; Guanylate Cyclase; Heme; Metalloporphyrins; Muscle Relaxation; Muscle, Smooth, Vascular; Myoglobin; Nitric Oxide; Oxyhemoglobins; Pulmonary Artery; Pulmonary Veins; Pyrogallol; Superoxide Dismutase

1987
The effect of cyclic AMP on heme synthesis by rat bone marrow cells.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 141, Issue:1

    Topics: Adenosine Monophosphate; Adenosine Triphosphate; Animals; Bone Marrow; Bone Marrow Cells; Butyrates; Cells, Cultured; Cyclic AMP; Cyclic GMP; Depression, Chemical; Dose-Response Relationship, Drug; Epinephrine; Erythropoietin; Heme; Imidazoles; In Vitro Techniques; Insulin; Iron; Iron Isotopes; Male; Rats; Stimulation, Chemical; Transferrin; Xanthines

1972
Cyclic nucleotide- and calcium-independent phosphorylation of proteins in rat brain polyribosome: effects of ACTH, spermine, and hemin.
    Neurochemical research, 1984, Volume: 9, Issue:9

    Topics: Adrenocorticotropic Hormone; Animals; Brain; Cyclic AMP; Cyclic GMP; Heme; Hemin; In Vitro Techniques; Nerve Tissue Proteins; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinases; Rats; Spermine

1984
Studies of N-methyl-N'-nitro-N-nitrosoguanidine action on the guanylate cyclase-guanosine 3'5' monophosphate system of isolated colonic epithelial cells.
    Cancer, 1980, Mar-15, Volume: 45, Issue:5 Suppl

    Topics: Animals; Biotransformation; Colon; Cyclic AMP; Cyclic GMP; Dithiothreitol; Enzyme Activation; Epithelium; Guanylate Cyclase; Heme; In Vitro Techniques; Male; Methylnitronitrosoguanidine; Nitric Oxide; Nitrites; Rabbits

1980
Increased responsiveness of the hepatic guanylate cyclase-guanosine 3',5'-monophosphate system to nitrosoguanidine following partial hepatectomy.
    Biochimica et biophysica acta, 1980, Apr-03, Volume: 628, Issue:4

    Topics: Animals; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Hepatectomy; Liver; Liver Regeneration; Male; Methylnitronitrosoguanidine; Rats; Subcellular Fractions

1980
Adenosine 3',5'-monophosphate formation by preparations of rat liver soluble guanylate cyclase activated with nitric oxide, nitrosyl ferroheme, S-nitrosothiols, and other nitroso compounds.
    Canadian journal of physiology and pharmacology, 1980, Volume: 58, Issue:12

    Topics: Adenosine Triphosphate; Animals; Cyclic AMP; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Hemeproteins; Kinetics; Liver; Male; Methylnitronitrosoguanidine; Nitric Oxide; Nitroprusside; Nitroso Compounds; Rats; Sulfhydryl Compounds

1980
Increased concentrations of cyclic GMP in fetal liver cells stimulated by erythropoietin.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1981, Volume: 166, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic AMP; Cyclic GMP; DNA; Erythropoietin; Heme; Liver; Rats

1981
Role of erythropoietin and cyclic nucleotides in erythroid cell proliferation in fetal liver.
    Experimental hematology, 1980, Volume: 8 Suppl 8

    Topics: Animals; Cell Cycle; Cyclic AMP; Cyclic GMP; DNA; Erythropoiesis; Erythropoietin; Fetus; Heme; Liver; Rats; Rats, Inbred Strains

1980
Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Mar-29, Volume: 91, Issue:7

    Topics: Amino Acid Sequence; Animals; Cyclic GMP; Enzyme Activation; Glutathione; Guanosine Triphosphate; Guanylate Cyclase; Heme; Histidine; Molecular Sequence Data; Mutation; Nitric Oxide; Nitroprusside; Nitroso Compounds; S-Nitrosoglutathione; Spectrophotometry

1994
[Soluble platelet guanylate cyclase: significance of heme in regulating enzymatic activity and the role of the enzyme in platelet aggregation].
    Biokhimiia (Moscow, Russia), 1994, Volume: 59, Issue:3

    Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Humans; In Vitro Techniques; Oxidation-Reduction; Platelet Aggregation; Rats; Solubility

1994
Nitric oxide formation during light-induced decomposition of phenyl N-tert-butylnitrone.
    The Journal of biological chemistry, 1993, Jun-05, Volume: 268, Issue:16

    Topics: Animals; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Guanylate Cyclase; Heme; Hemeproteins; Light; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes; Nitric Oxide; Nitrites; Nitrogen Oxides; Nitroprusside; Photolysis; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Spin Labels

1993
Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide.
    Biochemistry, 1996, Jan-30, Volume: 35, Issue:4

    Topics: Animals; Binding Sites; Cattle; Cyclic GMP; Enzyme Activation; Flow Injection Analysis; Guanylate Cyclase; Heme; Kinetics; Models, Chemical; Molecular Weight; Nitric Oxide; Signal Transduction; Solubility; Spectrophotometry

1996
Carbon monoxide: an endogenous modulator of the nitric oxide-cyclic GMP signaling system.
    Neuron, 1996, Volume: 16, Issue:4

    Topics: Animals; Animals, Newborn; Carbon Monoxide; Cells, Cultured; Cerebellum; Cyclic GMP; Drug Synergism; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Rats; Signal Transduction

1996
Effects of halothane and isoflurane on carbon monoxide-induced relaxations in the rat aorta.
    Anesthesiology, 1996, Volume: 85, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Aorta, Thoracic; Binding Sites; Carbon Dioxide; Cyclic GMP; Drug Interactions; Endothelium, Vascular; Halothane; Heme; In Vitro Techniques; Isoflurane; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents

1996
The regulation of heme turnover and carbon monoxide biosynthesis in cultured primary rat olfactory receptor neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Sep-15, Volume: 16, Issue:18

    Topics: Animals; Carbon Monoxide; Cell Differentiation; Cells, Cultured; Cyclic GMP; Heme; Heme Oxygenase (Decyclizing); Nerve Tissue; Neurons, Afferent; Olfactory Pathways; Rats; Sensory Receptor Cells

1996
Purification of bovine soluble guanylate cyclase and ADP-ribosylation on its small subunit by bacterial toxins.
    Journal of biochemistry, 1997, Volume: 122, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Diphosphate Ribose; Animals; Bacterial Toxins; Cattle; Cyclic GMP; Guanosine Triphosphate; Guanylate Cyclase; Heme; Kinetics; Lung; Macromolecular Substances; Manganese; NAD; Nitric Oxide; Sensitivity and Specificity; Solubility

1997
Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: role for nucleotide cyclases as oxygen sensors.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:2

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Biological Transport; Cell Line; Cyclic AMP; Cyclic GMP; Down-Regulation; Epithelial Cells; Guanylate Cyclase; Heme; Humans; Hypoxia; Intestinal Mucosa; Nucleotides, Cyclic; Oxygen; Water-Electrolyte Balance

1998
Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.
    British journal of pharmacology, 1998, Volume: 123, Issue:2

    Topics: Animals; Cattle; Cells, Cultured; Cerebellum; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Heme; Humans; In Vitro Techniques; Kinetics; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Oxazines; Rabbits; Solubility; Spectrophotometry; Structure-Activity Relationship; Swine; Umbilical Veins

1998
The deactivation of soluble guanylyl cyclase by redox-active agents.
    Archives of biochemistry and biophysics, 1998, Mar-01, Volume: 351, Issue:1

    Topics: Animals; Cattle; Cyclic GMP; Enzyme Activation; Ferricyanides; Guanylate Cyclase; Heme; Kinetics; Methylene Blue; Nitrates; Nitric Oxide; Oxidation-Reduction; Solubility

1998
Carbon monoxide and cerebral microvascular tone in newborn pigs.
    The American journal of physiology, 1999, Volume: 276, Issue:5

    Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Carbon Monoxide; Cerebral Arteries; Cerebrovascular Circulation; Chromium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Heme; Heme Oxygenase (Decyclizing); Lysine; Mesoporphyrins; Microcirculation; Nitroarginine; Pia Mater; Potassium Channels; Swine; Tetraethylammonium; Vasodilation; Vasodilator Agents

1999
NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; Cattle; Colforsin; Cyclic GMP; Electron Transport; Enzyme Activation; Enzyme Inhibitors; Ferricyanides; Flavoproteins; Glutathione; Guanylate Cyclase; Heme; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADP; Nitric Oxide; Oxadiazoles; Oxidation-Reduction; Penicillamine; Pentose Phosphate Pathway; Pulmonary Artery; Quinoxalines; Reactive Oxygen Species; Sulfhydryl Compounds

1999
Control of nitric oxide dynamics by guanylate cyclase in its activated state.
    The Journal of biological chemistry, 2001, Dec-14, Volume: 276, Issue:50

    Topics: Allosteric Site; Animals; Catalysis; Cattle; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Hydrogen-Ion Concentration; Kinetics; Ligands; Lung; Nitric Oxide; Oxygen; Protein Binding; Protein Conformation; Recombination, Genetic; Spectrophotometry

2001
On the activation of soluble guanylyl cyclase by nitric oxide.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Jan-08, Volume: 99, Issue:1

    Topics: Binding Sites; Cyclic GMP; Guanylate Cyclase; Heme; Humans; Kinetics; Models, Chemical; Nitric Oxide; Protein Binding; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Time Factors

2002
Role of the preoptic carbon monoxide pathway in endotoxin fever in rats.
    Brain research, 2002, Feb-08, Volume: 927, Issue:1

    Topics: Animals; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Endotoxemia; Enzyme Inhibitors; Fever; Heme; Heme Oxygenase (Decyclizing); Injections, Intraventricular; Lipopolysaccharides; Lysine; Male; Methylene Blue; Microinjections; Preoptic Area; Rats; Rats, Wistar; Vasodilator Agents

2002
Functional expression of human heme oxygenase-1 (HO-1) driven by HO-1 promoter in vitro and in vivo.
    Journal of cellular biochemistry, 2002, Volume: 85, Issue:2

    Topics: Animals; Animals, Newborn; Blotting, Western; Carbon Monoxide; Cells, Cultured; Cyclic GMP; Dinoprostone; Endothelium, Vascular; Gene Expression; Gene Expression Regulation, Enzymologic; Genetic Vectors; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Lung; Membrane Proteins; Mice; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Retroviridae; RNA, Messenger

2002
Cerebrovasodilatory contribution of endogenous carbon monoxide during seizures in newborn pigs.
    Pediatric research, 2002, Volume: 51, Issue:5

    Topics: Animals; Animals, Newborn; Arterioles; Bicuculline; Carbon Monoxide; Cerebral Arteries; Cerebrovascular Circulation; Convulsants; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; GABA Antagonists; Glutamates; Heme; Heme Oxygenase (Decyclizing); Membrane Potentials; Mesoporphyrins; Metalloporphyrins; Nerve Tissue Proteins; Neurons; Pia Mater; Protoporphyrins; Seizures; Status Epilepticus; Swine; Vasodilation

2002
Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2002, Volume: 283, Issue:5

    Topics: Animals; Cyclic GMP; Endothelium, Vascular; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Pulmonary Circulation; Rats; Recombinant Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Transfection

2002
Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization.
    American journal of physiology. Heart and circulatory physiology, 2003, Volume: 285, Issue:1

    Topics: Animals; Biliverdine; Calcium Signaling; Carbon Monoxide; Cell Membrane; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heme; Heme Oxygenase (Decyclizing); Large-Conductance Calcium-Activated Potassium Channels; Lysine; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Ryanodine; Vascular Resistance; Vasodilation

2003
Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.
    Experimental biology and medicine (Maywood, N.J.), 2003, Volume: 228, Issue:5

    Topics: Animals; Antioxidants; Azoles; Catalase; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Isoindoles; Lung; Maleates; Membrane Proteins; Nitric Oxide Synthase; Nitroarginine; Organoselenium Compounds; Oxidants; Rats; Reactive Oxygen Species; Transfection

2003
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Aug-05, Volume: 100, Issue:16

    Topics: Animals; Calcitonin; Cyclic GMP; Cytosol; Dimerization; Dogs; Dose-Response Relationship, Drug; Glutathione; Heme; Kinetics; Male; Models, Chemical; Nitric Oxide; Nitrogen; Oxidation-Reduction; Oxygen; Peptides; Protein Binding

2003
Preparation of heme-free soluble guanylate cyclase.
    Protein expression and purification, 2003, Volume: 31, Issue:1

    Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc

2003
Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues.
    The Journal of biological chemistry, 2004, Mar-19, Volume: 279, Issue:12

    Topics: Animals; Cyclic GMP; Electron Spin Resonance Spectroscopy; Female; Heme; Luminescent Measurements; Myocardial Ischemia; Nitric Oxide; Rats; Rats, Sprague-Dawley; Signal Transduction

2004
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.
    Nature, 2004, Jul-15, Volume: 430, Issue:6997

    Topics: Animals; Bacteria; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Aggregation; Cyclic GMP; Feeding Behavior; Food; Gases; Guanylate Cyclase; Heme; Hyperoxia; Ion Channels; Mutation; Neurons, Afferent; Nitric Oxide; Oxygen; Protein Binding; Protein Structure, Tertiary; Social Behavior

2004
Nitric oxide-induced modification of protein thiolate clusters as determined by spectral fluorescence resonance energy transfer in live endothelial cells.
    Free radical biology & medicine, 2004, Sep-15, Volume: 37, Issue:6

    Topics: Animals; Cells, Cultured; Cyclic GMP; Cysteine; Dithiothreitol; Endothelium, Vascular; Enzyme Activation; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Free Radicals; Genes, Reporter; Green Fluorescent Proteins; Guanylate Cyclase; Heme; Microscopy, Fluorescence; Nitric Oxide; Nitroso Compounds; Peptides; Protein Conformation; Proteins; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Sheep; Signal Transduction; Soluble Guanylyl Cyclase; Spectrometry, Fluorescence; Sulfhydryl Compounds

2004
NO activation of guanylyl cyclase.
    The EMBO journal, 2004, Nov-10, Volume: 23, Issue:22

    Topics: Catalysis; Cyclic GMP; Diphosphates; Enzyme Activation; Ferrous Compounds; Guanylate Cyclase; Heme; Histidine; Ligands; Magnesium; Models, Chemical; Nitric Oxide; Protein Binding; Signal Transduction; Spectrophotometry, Ultraviolet

2004
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
    European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection

2005
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation.
    Blood, 2006, Jan-15, Volume: 107, Issue:2

    Topics: Adenosine Triphosphate; Allosteric Regulation; Cell Hypoxia; Cyclic GMP; Erythrocytes; Heme; Hemoglobins; Humans; Mitochondria; Mutation; Nitric Oxide; Nitrite Reductases; Nitrites; Oxidation-Reduction; Oxygen; Respiration; Vasodilation

2006
Identification of residues crucially involved in soluble guanylate cyclase activation.
    FEBS letters, 2006, Jul-24, Volume: 580, Issue:17

    Topics: Animals; Cyclic GMP; Enzyme Activation; Guanylate Cyclase; Heme; Models, Molecular; Protein Structure, Tertiary; Rats; Structural Homology, Protein; Structure-Activity Relationship; Substrate Specificity; Thermoanaerobacter

2006
Role of the locus coeruleus carbon monoxide pathway in endotoxin fever in rats.
    Pflugers Archiv : European journal of physiology, 2007, Volume: 453, Issue:4

    Topics: Animals; Body Temperature; Carbon Monoxide; Central Nervous System; Cyclic GMP; Enzyme Inhibitors; Fever; Guanylate Cyclase; Heme; Heme Oxygenase (Decyclizing); Lipopolysaccharides; Locus Coeruleus; Lysine; Male; Rats; Rats, Wistar; Signal Transduction

2007
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
    The Journal of clinical investigation, 2006, Volume: 116, Issue:9

    Topics: Animals; Benzoates; Blood Pressure; Blood Vessels; Cell Culture Techniques; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; Heme; Oxidation-Reduction; Oxidative Stress; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Swine; Vasodilation

2006
Role of the peripheral heme oxygenase-carbon monoxide pathway on the nociceptive response of rats to the formalin test: evidence for a cGMP signaling pathway.
    European journal of pharmacology, 2007, Feb-05, Volume: 556, Issue:1-3

    Topics: Animals; Biliverdine; Carbon Monoxide; Cyclic GMP; Deferoxamine; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Iron Chelating Agents; Lysine; Male; Pain; Pain Measurement; Rats; Rats, Wistar; Signal Transduction

2007
Critical role of the heme axial ligand, Met95, in locking catalysis of the phosphodiesterase from Escherichia coli (Ec DOS) toward Cyclic diGMP.
    The Journal of biological chemistry, 2007, Jul-20, Volume: 282, Issue:29

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Carbon Monoxide; Catalysis; Cyclic GMP; Escherichia coli; Heme; Iron; Ligands; Methionine; Models, Molecular; Nitric Oxide; Oxygen; Phosphoric Diester Hydrolases; Protein Binding; Protein Conformation

2007
Role of the spinal cord heme oxygenase-carbon monoxide-cGMP pathway in the nociceptive response of rats.
    European journal of pharmacology, 2008, Feb-26, Volume: 581, Issue:1-2

    Topics: Animals; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Lysine; Male; Methylene Blue; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord

2008
Probing the presence of the ligand-binding haem in cellular nitric oxide receptors.
    British journal of pharmacology, 2008, Volume: 153, Issue:7

    Topics: Animals; Benzoates; Binding Sites; Blood Platelets; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; Drug Delivery Systems; Guanylate Cyclase; Heme; Ligands; Nitric Oxide; Oxidation-Reduction; Phosphorylation; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2008
Role of locus coeruleus heme oxygenase-carbon monoxide-cGMP pathway during hypothermic response to restraint.
    Brain research bulletin, 2008, Mar-28, Volume: 75, Issue:5

    Topics: Animals; Behavior, Animal; Body Temperature; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Hypothermia; Locus Coeruleus; Lysine; Male; Microinjections; Rats; Rats, Wistar; Restraint, Physical

2008
Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.
    Cancer research, 2008, Jun-15, Volume: 68, Issue:12

    Topics: Apoptosis; Blotting, Western; Breast; Breast Neoplasms; Cell Cycle; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media, Serum-Free; Cyclic GMP; eIF-2 Kinase; Enzyme Activation; Eukaryotic Initiation Factor-2; Female; Free Radical Scavengers; Genes, ras; Heme; Humans; Hydrogen Peroxide; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Oxidants; Oxidative Stress; Phosphorylation; Protein Biosynthesis; RNA, Small Interfering

2008
Arg97 at the heme-distal side of the isolated heme-bound PAS domain of a heme-based oxygen sensor from Escherichia coli (Ec DOS) plays critical roles in autoxidation and binding to gases, particularly O2.
    Biochemistry, 2008, Aug-26, Volume: 47, Issue:34

    Topics: Arginine; Carbon Monoxide; Carrier Proteins; Crystallography, X-Ray; Cyclic GMP; Escherichia coli Proteins; Ferric Compounds; Ferrous Compounds; Heme; Iron; Models, Molecular; Mutagenesis, Site-Directed; Nitric Oxide; Oxidation-Reduction; Oxygen; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship

2008
O2- and NO-sensing mechanism through the DevSR two-component system in Mycobacterium smegmatis.
    Journal of bacteriology, 2008, Volume: 190, Issue:20

    Topics: Amino Acid Sequence; Bacterial Proteins; Crystallography, X-Ray; Cyclic AMP; Cyclic GMP; Ferrous Compounds; Heme; Models, Molecular; Molecular Sequence Data; Mycobacterium smegmatis; Nitric Oxide; Oxygen; Phosphorylation; Protamine Kinase; Protein Structure, Tertiary; Sequence Alignment; Signal Transduction; Ubiquinone; Vitamin K 2

2008
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:4

    Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Male; Models, Molecular; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; ortho-Aminobenzoates; Oxidants; Oxidative Stress; Protein Conformation; Protein Structure, Tertiary; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Sulfonamides; Transfection; Vasodilator Agents

2008
Ligand binding to the Fe(III)-protoporphyrin IX complex of phosphodiesterase from Escherichia coli (Ec DOS) markedly enhances catalysis of cyclic di-GMP: roles of Met95, Arg97, and Phe113 of the putative heme distal side in catalytic regulation and ligand
    Biochemistry, 2008, Dec-16, Volume: 47, Issue:50

    Topics: Animals; Arginine; Catalysis; Cattle; Cyclic GMP; Escherichia coli Proteins; Ferric Compounds; Heme; Ligands; Methionine; Mutagenesis, Site-Directed; Phenylalanine; Phosphoric Diester Hydrolases; Protein Binding; Protein Structure, Tertiary; Protoporphyrins

2008
Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation.
    Circulation research, 2009, Jul-02, Volume: 105, Issue:1

    Topics: Blood Vessels; Cell Line; Cyclic GMP; Guanylate Cyclase; Heme; Humans; Nitric Oxide; Oxidation-Reduction; Proteasome Endopeptidase Complex; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Ubiquitination; Vasodilator Agents

2009
Heme-arginate suppresses phospholipase C and oxidative stress in the mesenteric arterioles of mineralcorticoid-induced hypertensive rats.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:4

    Topics: Animals; Arginine; Arterioles; Blood Pressure; Calcium; Cyclic GMP; Desoxycorticosterone; Dinoprost; Endothelin-1; Heme; Heme Oxygenase (Decyclizing); Hypertension; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Male; Mesenteric Arteries; Mineralocorticoids; NF-kappa B; Organometallic Compounds; Oxidative Stress; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Sodium Chloride, Dietary; Type C Phospholipases; Up-Regulation

2010
Cyclic di-GMP activation of polynucleotide phosphorylase signal-dependent RNA processing.
    Journal of molecular biology, 2011, Apr-15, Volume: 407, Issue:5

    Topics: Cyclic GMP; Endoribonucleases; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Heme; Macromolecular Substances; Oxygen; Phosphopyruvate Hydratase; Polyribonucleotide Nucleotidyltransferase; RNA; Second Messenger Systems

2011
Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Benzoates; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Cysteine; Enzyme Activation; Enzyme Activators; Fluorescence; Fluorescent Dyes; Guanylate Cyclase; Heme; Humans; Molecular Sequence Data; Mutation; Nitric Oxide; Oxadiazoles; Oxazines; Oxidation-Reduction; Protein Engineering; Receptors, Cytoplasmic and Nuclear; Rotenone; Signal Transduction; Soluble Guanylyl Cyclase; Spectrometry, Fluorescence

2011
Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization.
    The Journal of biological chemistry, 2011, Dec-16, Volume: 286, Issue:50

    Topics: Animals; Cell Line; Cyclic GMP; Guanylate Cyclase; Heme; Humans; Models, Biological; Nitric Oxide; Protein Binding; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Spodoptera

2011
Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation.
    Circulation research, 2012, Jan-20, Volume: 110, Issue:2

    Topics: Animals; Benzoates; Biphenyl Compounds; Cardiomegaly; Caveolin 3; Cyclic GMP; Disease Models, Animal; Down-Regulation; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Hydrocarbons, Fluorinated; Hydrolysis; Membrane Microdomains; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Nitric Oxide; Oxidation-Reduction; Protein Transport; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase

2012
Hydrogen sulfide stimulates the catalytic activity of a heme-regulated phosphodiesterase from Escherichia coli (Ec DOS).
    Journal of inorganic biochemistry, 2012, Volume: 109

    Topics: Catalysis; Cyclic GMP; Escherichia coli; Heme; Hydrogen Sulfide; Mutagenesis, Site-Directed; Phosphoric Diester Hydrolases; Spectrophotometry, Ultraviolet

2012
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.
    Molecular pharmacology, 2012, Volume: 82, Issue:3

    Topics: Animals; Aorta; Biopterins; Cardiovascular Diseases; Cells, Cultured; Cyclic GMP; Endothelial Cells; Fibroblasts; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Pterins; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Swine

2012
Nitric oxide- and heme-independent activation of soluble guanylate cyclase attenuates peroxynitrite-induced endothelial dysfunction in rat aorta.
    Journal of cardiovascular pharmacology and therapeutics, 2013, Volume: 18, Issue:1

    Topics: Animals; Aorta, Thoracic; Benzoates; Cyclic GMP; DNA Breaks; Endothelium, Vascular; Guanylate Cyclase; Heme; In Vitro Techniques; Male; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilation

2013
Interactions of soluble guanylate cyclase with a P-site inhibitor: effects of gaseous heme ligands, azide, and allosteric activators on the binding of 2'-deoxy-3'-GMP.
    Biochemistry, 2012, Nov-20, Volume: 51, Issue:46

    Topics: Allosteric Regulation; Azides; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heme; Ligands; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2012
An HD-GYP cyclic di-guanosine monophosphate phosphodiesterase with a non-heme diiron-carboxylate active site.
    Biochemistry, 2013, Aug-13, Volume: 52, Issue:32

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Bacterial Proteins; Catalytic Domain; Cyclic GMP; Heme; Iron; Models, Molecular; Protein Structure, Tertiary; Vibrio cholerae

2013
A structural basis for the regulation of an H-NOX-associated cyclic-di-GMP synthase/phosphodiesterase enzyme by nitric oxide-bound H-NOX.
    Biochemistry, 2014, Apr-08, Volume: 53, Issue:13

    Topics: Bacterial Proteins; Biofilms; Cyclic GMP; Escherichia coli Proteins; Heme; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Mutant Proteins; Nitric Oxide; Oxygen; Phosphoric Diester Hydrolases; Phosphorus-Oxygen Lyases; Shewanella

2014
Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension.
    European journal of pharmacology, 2014, Jul-05, Volume: 734

    Topics: Adiponectin; Aldosterone; Animals; Antioxidants; Arginine; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomyopathies; Cardiotonic Agents; Chemokine CCL2; Chemokine CCL3; Cyclic GMP; Dinoprost; Endothelin-1; Enzyme Induction; Extracellular Matrix Proteins; Heart Failure; Heme; Heme Oxygenase (Decyclizing); Hypertension; Interleukin-1beta; Interleukin-6; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine

2014
Acute stress-induced antinociception is cGMP-dependent but heme oxygenase-independent.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2014, Volume: 47, Issue:12

    Topics: Acute Pain; Animals; Carbon Monoxide; Cyclic GMP; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Lysine; Male; Nociceptive Pain; Oxadiazoles; Pain Measurement; Rats, Wistar; Signal Transduction; Stress Disorders, Traumatic, Acute

2014
Chronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Animals; Blood Pressure; Cyclic GMP; Glomerular Filtration Rate; Guanylate Cyclase; Heme; Kidney; Male; Nitric Oxide; Rats; Rats, Inbred Dahl; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2015
Oxygen and Bis(3',5')-cyclic Dimeric Guanosine Monophosphate Binding Control Oligomerization State Equilibria of Diguanylate Cyclase-Containing Globin Coupled Sensors.
    Biochemistry, 2016, Dec-06, Volume: 55, Issue:48

    Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Biocatalysis; Biofilms; Bordetella pertussis; Cyclic GMP; Escherichia coli Proteins; Globins; Heme; Hemeproteins; Kinetics; Models, Molecular; Mutation; Oxygen; Pectobacterium carotovorum; Phosphorus-Oxygen Lyases; Protein Binding; Protein Domains; Protein Multimerization; Sequence Homology, Amino Acid

2016
Erectile Dysfunction in Heme-Deficient Nitric Oxide-Unresponsive Soluble Guanylate Cyclase Knock-In Mice.
    The journal of sexual medicine, 2017, Volume: 14, Issue:2

    Topics: Animals; Cyclic GMP; Disease Models, Animal; Erectile Dysfunction; Guanylate Cyclase; Heme; Humans; Male; Mice; Nitric Oxide; Penile Erection; Penis; Soluble Guanylyl Cyclase

2017
The NO-heme signaling hypothesis.
    Free radical biology & medicine, 2017, Volume: 112

    Topics: Animals; Cyclic GMP; Endothelium-Dependent Relaxing Factors; Enzyme Activation; Gene Expression; Heme; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitrosation; Protein Processing, Post-Translational; Signal Transduction; Soluble Guanylyl Cyclase; Vasodilation

2017
NosP Signaling Modulates the NO/H-NOX-Mediated Multicomponent c-Di-GMP Network and Biofilm Formation in
    Biochemistry, 2019, 12-03, Volume: 58, Issue:48

    Topics: Bacterial Proteins; Biofilms; Cyclic GMP; Gene Expression Regulation, Bacterial; Heme; Nitric Oxide; Shewanella; Signal Transduction

2019
Inflammation in the Human Periodontium Induces Downregulation of the α
    International journal of molecular sciences, 2021, Jan-07, Volume: 22, Issue:2

    Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cyclic GMP; Gene Expression Regulation; Heme; Humans; Inflammation; Iron; Nitric Oxide; Osteoclasts; Oxidation-Reduction; Periodontal Ligament; Periodontium; Soluble Guanylyl Cyclase

2021
Inactivation of soluble guanylyl cyclase in living cells proceeds without loss of haem and involves heterodimer dissociation as a common step.
    British journal of pharmacology, 2022, Volume: 179, Issue:11

    Topics: Cyclic GMP; Guanylate Cyclase; HEK293 Cells; Heme; Humans; Nitric Oxide; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2022
Heme-Edge Residues Modulate Signal Transduction within a Bifunctional Homo-Dimeric Sensor Protein.
    Biochemistry, 2021, 12-14, Volume: 60, Issue:49

    Topics: Amino Acid Sequence; Amino Acid Substitution; Bacterial Proteins; Binding Sites; Cyclic GMP; Escherichia coli; Escherichia coli Proteins; Gene Expression; Heme; Hemeproteins; Kinetics; Models, Molecular; Oxygen; Paenibacillus; Phosphoric Diester Hydrolases; Phosphorus-Oxygen Lyases; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Static Electricity; Structure-Activity Relationship; Substrate Specificity

2021
NO rapidly mobilizes cellular heme to trigger assembly of its own receptor.
    Proceedings of the National Academy of Sciences of the United States of America, 2022, 01-25, Volume: 119, Issue:4

    Topics: Animals; Calcium; Cyclic GMP; Glyceraldehyde-3-Phosphate Dehydrogenases; Guanylate Cyclase; Heme; HSP90 Heat-Shock Proteins; Humans; Mice; Models, Biological; Nitric Oxide; Protein Binding; Protein Multimerization; Protein Transport; Receptors, Cell Surface; Signal Transduction; Soluble Guanylyl Cyclase

2022
The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms.
    Scientific reports, 2022, 03-04, Volume: 12, Issue:1

    Topics: Animals; Cyclic GMP; Guanylate Cyclase; Heme; Hippocampus; Male; Mice; Neuronal Plasticity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Soluble Guanylyl Cyclase; Vasodilator Agents

2022
The differential roles of the two NO-GC isoforms in adjusting airway reactivity.
    American journal of physiology. Lung cellular and molecular physiology, 2022, 10-01, Volume: 323, Issue:4

    Topics: Animals; Bronchoconstrictor Agents; Cyclic GMP; Guanylate Cyclase; Heme; Methacholine Chloride; Mice; Mice, Knockout; Nitric Oxide; Ovalbumin; Protein Isoforms; Soluble Guanylyl Cyclase; Vasodilator Agents

2022
Dental Pulp Inflammation Initiates the Occurrence of Mast Cells Expressing the α
    International journal of molecular sciences, 2023, Jan-04, Volume: 24, Issue:2

    Topics: Cyclic GMP; Dental Pulp; Guanylate Cyclase; Heme; Humans; Inflammation; Nitric Oxide; Soluble Guanylyl Cyclase

2023
BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Complex.
    Molecular pharmacology, 2023, Volume: 103, Issue:5

    Topics: Animals; Cyclic GMP; Guanylate Cyclase; Heat-Shock Proteins; HEK293 Cells; Heme; Humans; Nitric Oxide; Rats; Signal Transduction; Soluble Guanylyl Cyclase

2023
NO binds to the distal site of haem in the fully activated soluble guanylate cyclase.
    Nitric oxide : biology and chemistry, 2023, 05-01, Volume: 134-135

    Topics: Cyclic GMP; Guanylate Cyclase; Heme; Nitric Oxide; Soluble Guanylyl Cyclase

2023
The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats.
    International journal of molecular sciences, 2023, Aug-25, Volume: 24, Issue:17

    Topics: Animals; Clinical Trials, Phase II as Topic; Cyclic GMP; Glycated Hemoglobin; Heme; Kidney; Obesity; Proteinuria; Rats; Renal Insufficiency, Chronic

2023
chemdatabank.com