heme has been researched along with biliverdine in 187 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (24.06) | 18.7374 |
| 1990's | 11 (5.88) | 18.2507 |
| 2000's | 70 (37.43) | 29.6817 |
| 2010's | 45 (24.06) | 24.3611 |
| 2020's | 16 (8.56) | 2.80 |
| Authors | Studies |
|---|---|
| Hino, Y; Minakami, S | 1 |
| Kikuchi, G; Noguchi, M; Yoshida, T | 4 |
| Kikuchi, G; Yoshida, T | 1 |
| Asagami, H; Hino, Y; Minakami, S | 1 |
| Brown, SB; Chaney, BD | 1 |
| Masters, BS; Schacter, BA | 1 |
| Holbrook, DJ; Krasny, HC | 1 |
| Lähdevirta, J; Tenhunen, R | 1 |
| Brown, SB; Grundy, MS | 1 |
| Bradley, TB; Brown, SB; Docherty, JC | 1 |
| Ross, J; Sautner, D | 1 |
| Brown, SB | 1 |
| Colleran, E; O'Carra, P | 1 |
| Cooper, G; Games, DE; Jackson, AH | 1 |
| Tenhunen, R | 2 |
| Schmid, R | 1 |
| Anttinen, M; Mähönen, Y; Tenhunen, R; Vuopio, P | 1 |
| Cheung, BS; Kwak, JY; Minakami, S; Takeshige, K | 1 |
| Celier, C; Cresteil, T | 1 |
| Sano, S; Sudo, Y; Yoshinaga, T | 1 |
| Aw, TY; Bonkovsky, HL; Lincoln, BC | 1 |
| Daniel, RF; Kutty, RK; Levin, W; Maines, MD; Ryan, DE | 1 |
| Maeda, Y; Morishima, I; Sano, S; Sano, T; Shiro, Y | 1 |
| Bonkovsky, HL; Healey, JF; Howell, SK; Lincoln, B; Sinclair, JF; Sinclair, PR; Wood, SG | 1 |
| Buldain, G; Frydman, B; Frydman, RB; Tomaro, ML | 1 |
| Leeper, FJ | 1 |
| Guengerich, FP; Harris, TM; Schaefer, WH | 1 |
| Hirota, T; Itano, HA | 1 |
| Hirota, K; Itano, HA; Yamamoto, S | 1 |
| Kikuchi, G | 1 |
| Beale, SI; Cornejo, J | 1 |
| Docherty, JC; Firneisz, GD; Schacter, BA | 1 |
| Brown, SB; Docherty, JC | 2 |
| Kutty, RK; Maines, MD | 1 |
| Docherty, JC; Firneisz, GD; Masters, BS; Schacter, BA | 1 |
| Moore, MR | 1 |
| McDonagh, AF; Palma, LA | 1 |
| Dallas, JL; Sharkus, LC; Smith, KM | 1 |
| Novogrodsky, A; Rubin, AL; Stenzel, KH | 1 |
| Bergstrom, DE; Blumenthal, SG; Rasmussen, RD; Ruebner, BH; Yokoyama, WH | 1 |
| Imbenotte, J; Verger, C | 1 |
| Kendrick, RE; Terry, MJ | 1 |
| Ortiz de Montellano, PR; Torpey, J | 1 |
| Bend, JR; Sinal, CJ | 1 |
| Forsling, ML; Grossman, AB; Kostoglou-Athanassiou, I; Mancuso, C; Minotti, G; Navarra, P; Preziosi, P | 1 |
| Liu, H; Mount, DB; Nasjletti, A; Wang, W | 1 |
| Barker, PD; Fearnley, IM; Rice, JK | 1 |
| Cunningham, O; Gore, MG; Mantle, TJ | 1 |
| Fujita, H; Ogawa, K; Shibahara, S | 1 |
| Liu, Y; Ortiz de Montellano, PR | 1 |
| Colpaert, EE; Lefebvre, RA | 1 |
| Montellano, PR | 1 |
| Moënne-Loccoz, P; Wilks, A | 1 |
| Schüller Pérez, A | 1 |
| Baldini, F; Bechi, P; Cianchi, F; Falai, A; Fiorillo, C; Nassi, P | 1 |
| Adachi, Y; Noguchi, M; Omata, Y; Palmer, G; Sakamoto, H | 1 |
| McDonagh, AF | 1 |
| Kikuchi, A; Miyatake, H; Park, SY; Sato, M; Shiro, Y; Sun, D; Yoshida, T | 1 |
| Deshmukh, R; Ratliff, M; Stojiljkovic, I; Wilks, A; Zhu, W | 1 |
| Anselmo, DM; Busuttil, RW; Katori, M; Kupiec-Weglinski, JW | 1 |
| Wilks, A | 1 |
| Kukoba, TV; Moĭbenko, OO | 1 |
| Bunce, RA; Caignan, GA; Deshmukh, R; Eastman, MA; Huang, HW; Moënne-Loccoz, P; Rivera, M; Wilks, A; Zeng, Y | 1 |
| Migita, CT; Yoshida, T; Zhang, X | 1 |
| Naik, JS; Walker, BR | 1 |
| Avila, L; Damaso, CO; Huang, HW; Lu, S; Moënne-Loccoz, P; Rivera, M | 1 |
| Sugimoto, A; Yamaguchi, T | 1 |
| Fukuyama, K; Higashimoto, Y; Noguchi, M; Sakamoto, H; Sugishima, M | 2 |
| Fujii, H; Ikeda-Saito, M; Matera, KM; Migita, CT; Sato, M; Sun, D; Yoshida, T; Zhang, X | 1 |
| Bach, FH; Otterbein, LE; Soares, MP; Yamashita, K | 1 |
| NAKAJIMA, H; NAKAJIMA, O; TAKEMURA, T; YAMAOKA, K | 1 |
| NAKAJIMA, H | 1 |
| Chao, MP; Pendrak, ML; Roberts, DD; Yan, SS | 1 |
| Bach, FH; Berberat, PO; Csizmadia, E; McDaid, J; Ollinger, R; Smith, RN; Soares, MP; Tsui, TY; Usheva, A; Yamashita, K | 1 |
| Bhaskar, B; Friedman, J; Lad, L; Li, H; Ortiz de Montellano, PR; Poulos, TL | 1 |
| Balch, AL; Latos-Grazyński, L; Nguyen, KT; Olmstead, MM; Rath, SP | 1 |
| Cheng, KM; Godin, DV; Hoekstra, KA | 1 |
| Alvarez, DE; Buldain, G; de Montellano, PR; Huang, L; Lad, L; Niemevz, F; Poulos, TL; Wang, J | 1 |
| Frankenberg-Dinkel, N; Rivera, M; Tasler, R; Wegele, R; Zeng, Y | 1 |
| Bauer, R; Brüggemann, H; Gottschalk, G; Raffestin, S | 1 |
| Sassa, S | 1 |
| Fondevila, C; Kupiec-Weglinski, JW; Tsuchihashi, S | 1 |
| Lad, L; Ortiz de Montellano, PR; Poulos, TL | 1 |
| Lad, L; Ortiz de Montellano, PR; Poulos, TL; Wang, J | 1 |
| Nikolic, D; Silverman, RB; Van Breemen, RB; Zhu, Y | 1 |
| Migita, CT; Sasahara, M; Sato, M; Yoshida, T; Zhang, X | 1 |
| Hu, Z; Lelli, KM; Maines, MD; Miralem, T; Torno, MD | 1 |
| Moulin, M; Smith, AG | 1 |
| Fujii, H; Ikeda-Saito, M; Matera, KM; Matsui, T; Migita, CT; Nakajima, A; Yoshida, T | 1 |
| Abraham, NG; Bolognesi, M; Di Pascoli, M; Rodella, L; Sacerdoti, D; Turkseven, S | 1 |
| Adin, CA; Kirkby, KA | 1 |
| Almeida, IC; Cruz-Oliveira, C; Dunkov, BC; Masuda, H; Maya-Monteiro, CM; Nakayasu, ES; Oliveira, PL; Paiva-Silva, GO | 1 |
| van den Hurk, P | 1 |
| Bach, FH | 2 |
| Bahrami, H; Safari, N; Zahedi, M | 1 |
| Abraham, NG; Falck, JR; Goodman, AI; Lamon, BD; Rezzani, R; Rodella, L; Sangras, B | 1 |
| O'Brian, MR; Puri, S | 1 |
| Branco, LG; Nascimento, CG | 1 |
| Bahrami, H; Gheidi, M; Safari, N; Zahedi, M | 1 |
| Fukuyama, K; Higashimoto, Y; Noguchi, M; Oishi, T; Sakamoto, H; Sugishima, M; Takahashi, H | 1 |
| Almeida, IC; Oliveira, PL; Paiva-Silva, GO; Pereira, LO | 1 |
| Chodorowski, Z; Kaletha, K; Rybakowska, I; Sein Anand, J | 1 |
| Rivera, M; Rodríguez, JC; Wilks, A; Zeng, Y | 1 |
| Bach, FH; Margreiter, R; Ollinger, R; Thomas, M; Wang, H; Wegiel, B; Yamashita, K | 1 |
| Bhakta, MN; Olabisi, A; Wilks, A; Wimalasena, K | 1 |
| Ghiasi, M; Jamaat, PR; Naghavi, SS; Safari, N; Zahedi, M | 1 |
| de Montellano, PR; Evans, JP; La Mar, GN; Ogura, H | 1 |
| Barkovits, K; Benkartek, C; Frankenberg-Dinkel, N; Harms, A; Smart, JL | 1 |
| Ikeda-Saito, M; Jin, H; Matsui, T; Omori, K | 1 |
| Buldain, G; de Montellano, PO; Evans, JP; Niemevz, F | 1 |
| Fischer, SM; Sana, TR; Waddell, K | 1 |
| Agarwal, A; Cisowski, J; Dulak, J; Grochot-Przeczek, A; Jazwa, A; Jozkowicz, A; Loboda, A; Rutkowski, AJ | 1 |
| Niittynen, M; Pohjanvirta, R; Tuomisto, JT | 1 |
| Bach, FH; Soares, MP | 1 |
| Choi, AM; Lin, L; Morse, D; Ryter, SW | 1 |
| Andreoletti, P; Capeillère-Blandin, C; Gouet, P; Jaquinod, M; Jouve, HM; Mouesca, JM | 1 |
| Choi, AM; Ryter, SW | 1 |
| McDonagh, AF; Stokes, JB; Uc, A | 1 |
| Gozzelino, R; Jeney, V; Soares, MP | 1 |
| Gheidi, M; Safari, N; Zahedi, M | 1 |
| Backes, WL; Huber, WJ; Reed, JR | 1 |
| Fan, W; Fu, S; He, H; Huang, F; Li, D; Zhu, X | 1 |
| Hoeger, U; Schenk, S | 1 |
| Anegon, I; Blancou, P; Carreño, L; Kalergis, A; Rémy, S; Simon, T; Tardif, V | 1 |
| Devey, LR; Richards, JA; Wigmore, SJ | 1 |
| Cui, WT; Feng, JF; Han, B; Jin, QJ; Shen, WB; Xu, S; Yuan, XX | 1 |
| Gorchein, A; Lim, CK; Lord, G | 1 |
| Aras, M; Frankenberg-Dinkel, N; Gisk, B; Wiethaus, J | 1 |
| Ikeda-Saito, M; Matsui, T; Unno, M | 1 |
| Henkel, T; März, A; Neugebauer, U; Popp, J; Schmitt, M | 1 |
| Arruda, MA; Assreuy, J; Barcellos-de-Souza, P; Barja-Fidalgo, C; Moraes, JA; Nascimento-Silva, V; Rodrigues, G; Silva, SV | 1 |
| Crowley, JR; Goldberg, DE; Henderson, JP; Hsieh, S; Sigala, PA | 1 |
| Maines, MD | 1 |
| Ryter, SW; Tyrrell, RM | 1 |
| González-Bayón, R; Hricová, A; Micol, JL; Ponce, MR; Quesada, V; Sarmiento-Mañús, R | 1 |
| Casero, D; Dent, RM; Duanmu, D; Gallaher, S; Grossman, AR; Lagarias, JC; Martin, SS; Merchant, SS; Niyogi, KK; Pellegrini, M; Rockwell, NC; Yang, W | 1 |
| Jarocka, I; Zapora, E | 1 |
| Li, DP; Liao, YF; Zhu, W; Zhu, X | 1 |
| Ardèvol, A; Ikeda-Saito, M; Rovira, C; Unno, M | 1 |
| Bezpalko, O; Kumar, S; Lajud, SA; Li, D; Mouchli, A; Nagda, DA; O'Malley, BW; Zheng, J | 1 |
| Duong, T; Hahn, MJ; Hwang, HY; Jang, I; Kang, SW; Kim, KK; Kim, T; Oh, HB; Park, K | 1 |
| Kayser, H; Nimtz, M; Wray, V | 1 |
| Ikeda-Saito, M; Wilks, A | 1 |
| Kayser, H; Müller, SA; Nimtz, M; Ringler, P | 1 |
| Bhuyan, J | 1 |
| Amarelle, V; Buldain, G; Fabiano, E; Lázaro-Martínez, JM; Noya, F; O'Brian, MR; Rosconi, F | 1 |
| Caaveiro, JM; Goldberg, DE; Morante, K; Sigala, PA; Tsumoto, K | 1 |
| Giardina, BJ; Mouriño, S; Reyes-Caballero, H; Wilks, A | 1 |
| Agarwal, A; Ayer, A; Stocker, R; Zarjou, A | 1 |
| Hermann, C; Meinel, L; Steiger, C | 1 |
| Chaurasia, AK; Choi, J; Ha, SC; Kim, D; Kim, H; Kim, KK; Kim, T | 1 |
| Busch, AW; Montgomery, BL; WareJoncas, Z | 1 |
| Barbagallo, I; Di Raimondo, F; Di Rosa, M; Forte, S; Giallongo, C; Li Volti, G; Signorelli, SS; Tibullo, D; Vanella, L | 1 |
| Bauer, M; Claudel, T; Coldewey, SM; Cuperus, F; Heinemann, SH; Nietzsche, S; Ojha, NK; Pohnert, G; Schleser, FA; Seidel, RA; Sponholz, C; Trauner, M; Westerhausen, M | 1 |
| Dojun, N; Ishigami, I; Ishimori, K; Lewis-Ballester, A; Matsui, T; Sekine, Y; Uchida, T; Yeh, SR | 1 |
| Hongo, Y; NagaI, S; Yasuda, N | 1 |
| Chen, YC; Elgass, KD; Htun, NM; Huang, AL; Lim, B; Maghzal, GJ; Peter, K; Rivera, J; Schiller, T; Schneider, HG; Stocker, R; Wood, BR | 1 |
| Ayer, A; Chen, W; Dunn, LL; Maghzal, GJ; Stocker, R; Suarna, C | 1 |
| Alavi, FS; Gheidi, M; Ryde, U; Safari, N; Zahedi, M | 1 |
| Higuchi, T; Iida, M; Ikeda-Saito, M; Matsui, T; Nambu, Y; Sakanashi, K; Suematsu, M; Sugiyama, R; Tamura, Y | 1 |
| Chao, A; Goulding, CW | 1 |
| Kishimoto, Y; Kondo, K; Momiyama, Y | 1 |
| Bottino-Rojas, V; Dunkov, BC; Oliveira, PL; Paiva-Silva, GO; Pereira, LOR; Silva, G; Talyuli, OAC | 1 |
| Burley, KH; Chao, A; Chen, X; de Miranda, R; Goulding, CW; Mobley, DL; Sieminski, PJ | 1 |
| Bahou, WF; Nesbitt, NM; Pereira, PJB; Zhang, B | 1 |
| Si, Z; Wang, X | 1 |
| Bahou, WF; Gnatenko, DV; Jares, A; Liu, Z; Ma, Y; Malone, LE; Nesbitt, NM; Zhu, W | 1 |
| Dicko, H; Duboisset, J; Durand, P; Ky, CL; Planes, S; Quintric, L; Reisser, C; Stenger, PL; Vidal-Dupiol, J | 1 |
| Beale, R; Cherepanov, P; Christodoulou, E; Cook, NJ; Doores, KJ; Dos Santos, MS; Fertleman, M; Graham, C; Heaney, J; Kassiotis, G; Kjær, S; MacRae, JI; Malim, MH; Masino, L; McClure, MO; McCoy, LE; Muir, L; Nans, A; Nastouli, E; Ng, KW; Parker, E; Pizzato, M; Pye, VE; Rees-Spear, C; Rhys, H; Riddell, A; Rosa, A; Rosadas, C; Rosenthal, PB; Roustan, C; Sanders, RW; Seow, J; Short, CE; Spyer, M; Susana, A; Taylor, GP; Tedder, RS; Ulferts, R; van Gils, MJ; Wrobel, AG | 1 |
| Vítek, L | 1 |
| Hou, YN; Kong, CD; Li, XD; Sha, N; Tan, ZZ; Zhao, KH | 1 |
| Dominic, IM; Fleischhacker, AS; Hamza, I; Hanna, DA; Liu, L; Moore, CM; Ragsdale, SW; Reddi, AR; Yuan, X | 1 |
| Connor, B; Lee, YS; Morris, AC; Passamonte, S; Rockenhaus, AE; Titialii-Torres, K | 1 |
| Bhadauria, M; Nirala, SK; Rakshit, S; Sahu, N | 1 |
| Silva, RCMC; Travassos, LH; Vasconcelos, LR | 1 |
| Badmus, OO; Hinds, TD; Stec, DE; Tiribelli, C | 1 |
| Carvalho, E; Leal, EC | 1 |
| Huber, T; Lemli, B; Lomozová, Z; Lukács, A; Poór, M | 1 |
| Ishikawa, K; Kodama, Y; Miyawaki, A; Numata, K; Osaki, Y; Xie, X | 1 |
| Mancuso, C | 1 |
39 review(s) available for heme and biliverdine
| Article | Year |
|---|---|
[Mechanism of heme catabolism (author's transl)].
Topics: Ascorbic Acid; Biliverdine; Cobalt; Heme; Heme Oxygenase (Decyclizing); Iron; Oxidation-Reduction; Protoporphyrins; Stereoisomerism | 1979 |
The biosynthesis of porphyrins, chlorophylls, and vitamin B12.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bile Pigments; Bilirubin; Biliverdine; Chlorophyll; Chlorophyllides; Cytochromes; Ferrochelatase; Heme; Hydroxymethylbilane Synthase; Metalloporphyrins; Metalloproteins; Nickel; Nucleotides; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plants; Porphobilinogen Synthase; Porphyrins; Protoporphyrinogen Oxidase; Uroporphyrinogen Decarboxylase; Uroporphyrinogen III Synthetase; Vitamin B 12 | 1985 |
[Heme catabolism: its mechanism and regulation].
Topics: Animals; Bile; Bilirubin; Biliverdine; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Humans; Iron; Mixed Function Oxygenases; NADP; Rabbits; Rats | 1983 |
The biochemistry of the porphyrins.
Topics: 5-Aminolevulinate Synthetase; Animals; Biliverdine; Cell Compartmentation; Chemistry Techniques, Analytical; Coproporphyrinogen Oxidase; Ferrochelatase; Heme; Heme Oxygenase (Decyclizing); Humans; Hydroxymethylbilane Synthase; Molecular Conformation; Oxidoreductases; Pharmacology; Photosensitivity Disorders; Porphobilinogen Synthase; Porphyrinogens; Porphyrins; Protoporphyrins; Pyrroles; Steroids; Uroporphyrinogen Decarboxylase | 1980 |
[Heme as a signaling molecule under environmental stress].
Topics: Animals; Antioxidants; Bilirubin; Biliverdine; Heme; Humans; Hypoxia; Oxidative Stress | 1999 |
The mechanism of heme oxygenase.
Topics: Animals; Biliverdine; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Hydroxylation; Membrane Proteins; Models, Chemical | 2000 |
[The heme oxygenase system and its physiopathology].
Topics: Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Humans; Hyperbilirubinemia; Iron; Porphyrias | 1999 |
A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system.
Topics: Animals; Biliverdine; Carbon Monoxide; Cytoprotection; Enzyme Induction; Free Radicals; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron; Ischemia; Membrane Proteins; Oxygen; Reperfusion Injury | 2002 |
Heme oxygenase: evolution, structure, and mechanism.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Biliverdine; Binding Sites; Evolution, Molecular; Heme; Heme Oxygenase (Decyclizing); Humans; Isoenzymes; Molecular Sequence Data; Molecular Structure; Oxygen; Protein Binding; Protein Conformation; Sequence Alignment; Substrate Specificity | 2002 |
[Heme oxygenase and carbon monoxide: the protection or the injury of cells?].
Topics: Animals; Biliverdine; Carbon Monoxide; Catalysis; Heme; Heme Oxygenase (Decyclizing); Oxidative Stress | 2002 |
[Diversity and anti-oxidative effects of bilirubin].
Topics: Animals; Antioxidants; Bilirubin; Biliverdine; Dipyrone; Free Radical Scavengers; Heme; Humans; Isomerism; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Stress, Psychological | 2003 |
Heme oxygenase-1: unleashing the protective properties of heme.
Topics: Animals; Bilirubin; Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Protective Agents; Signal Transduction | 2003 |
Protective role of heme oxygenase in the blood vessel wall during atherogenesis.
Topics: Animals; Antioxidants; Arteriosclerosis; Bilirubin; Biliverdine; Blood Vessels; Carbon Monoxide; Endothelium, Vascular; Ferritins; Gene Expression Regulation, Enzymologic; Genetic Therapy; Heme; Heme Oxygenase (Decyclizing); Humans; Isoenzymes; Lipoproteins, LDL; Oxidative Stress | 2004 |
Heme oxygenase system in ischemia and reperfusion injury.
Topics: Animals; Bilirubin; Biliverdine; Carbon Monoxide; Enzyme Induction; Ferritins; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron; Membrane Proteins; Reperfusion Injury | 2004 |
Regulation of tetrapyrrole biosynthesis in higher plants.
Topics: Aminolevulinic Acid; Biliverdine; Chlorophyll; Heme; Light; Plant Physiological Phenomena; Plants; Signal Transduction; Tetrapyrroles | 2005 |
[Structure and mechanism of heme oxygenase].
Topics: Animals; Bilirubin; Biliverdine; Carbon Monoxide; Catalysis; Electrons; Heme; Heme Oxygenase (Decyclizing); Humans; Iron; Ligands; NADPH-Ferrihemoprotein Reductase; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation | 2005 |
Products of heme oxygenase and their potential therapeutic applications.
Topics: Adult; Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase-1; Humans; Iron | 2006 |
Heme oxygenase-1 and transplantation tolerance.
Topics: Animals; Biliverdine; Carbon Monoxide; Graft Rejection; Heart Transplantation; Heme; Heme Oxygenase-1; Mice; Transplantation Tolerance | 2006 |
[Heme oxygenase as a potential therapeutic target for hepatoprotection].
Topics: Acetaminophen; Animals; Biliverdine; Carbon Monoxide; Catalysis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytoprotection; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Garlic; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Isoenzymes; Liver; Liver Diseases; Oxidative Stress; Protective Agents | 2007 |
Therapeutic applications of bilirubin and biliverdin in transplantation.
Topics: Animals; Bilirubin; Biliverdine; Cytoprotection; Graft Rejection; Heme; Heme Oxygenase-1; Humans; Islets of Langerhans Transplantation; Models, Biological; Molecular Structure; Organ Transplantation; Reperfusion Injury; Transplantation, Homologous | 2007 |
Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities.
Topics: Animals; Apoptosis; Biliverdine; Carbon Monoxide; Cardiovascular Agents; Cardiovascular Diseases; Child; Diabetes Complications; Endothelium, Vascular; Enzyme Induction; Female; Genetic Therapy; Heme; Heme Oxygenase-1; Humans; Inflammation; Iron; Male; Mice; Mice, Knockout; Neovascularization, Physiologic; Rabbits; Rats; Vasomotor System | 2008 |
Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease.
Topics: Animals; Apoptosis; Biliverdine; Carbon Monoxide; Cell Proliferation; Heme; Heme Oxygenase-1; Humans; Iron; Lung; Organ Transplantation; Oxidative Stress; Reperfusion Injury; Signal Transduction; STAT Transcription Factors | 2009 |
Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy.
Topics: Animals; Bilirubin; Biliverdine; Carbon Monoxide; Clinical Trials as Topic; Cytoprotection; Genetic Therapy; Heme; Heme Oxygenase-1; Homeostasis; Humans; Iron; Molecular Structure; Oxidative Stress; Signal Transduction | 2009 |
Mechanisms of cell protection by heme oxygenase-1.
Topics: Animals; Apoptosis; Biliverdine; Carbon Monoxide; Cytoprotection; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase-1; Humans; Inflammation; Tumor Necrosis Factor-alpha | 2010 |
The heme oxygenase system and oral diseases.
Topics: Bilirubin; Biliverdine; Carbon Dioxide; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron; Isoenzymes; Mouth Diseases | 2011 |
Crystallographic studies of heme oxygenase complexed with an unstable reaction intermediate, verdoheme.
Topics: Biliverdine; Catalysis; Crystallography, X-Ray; Heme; Heme Oxygenase (Decyclizing); Humans; Models, Molecular; Oxidation-Reduction; Oxygen; Photochemical Processes; Quantum Theory; Water | 2012 |
Overview of heme degradation pathway.
Topics: Animals; Bilirubin; Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron; Molecular Structure; Oxidation-Reduction | 2001 |
[Hemoglobin--source of reactive oxygen species].
Topics: Animals; Biliverdine; Carbon Monoxide; Cytoprotection; Erythrocytes; Heme; Heme Oxygenase (Decyclizing); Hemoglobins; Humans; Hydrogen Peroxide; Iron; Lipid Peroxidation; Oxidation-Reduction; Reactive Oxygen Species | 2013 |
Heme oxygenase-1 and gut ischemia/reperfusion injury: A short review.
Topics: Animals; Bilirubin; Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase-1; Humans; Intestines; Iron; Reperfusion Injury; Signal Transduction | 2013 |
Heme Oxygenases in Cardiovascular Health and Disease.
Topics: Animals; Biliverdine; Carbon Monoxide; Cardiovascular Diseases; Cardiovascular System; Heme; Heme Oxygenase (Decyclizing); Humans; Iron | 2016 |
Localized delivery of carbon monoxide.
Topics: Administration, Cutaneous; Administration, Inhalation; Administration, Oral; Animals; Biliverdine; Carbon Monoxide; Carboxyhemoglobin; Coronary Artery Disease; Diabetes Mellitus; Disease Models, Animal; Drug Delivery Systems; Heme; Heme Oxygenase-1; Humans; Organ Transplantation; Organometallic Compounds; Reperfusion Injury; Signal Transduction; Tissue Distribution | 2017 |
The Heme Oxygenase System in Hematological Malignancies.
Topics: Animals; Antineoplastic Agents; Biliverdine; Carbon Monoxide; Epigenesis, Genetic; Hematologic Neoplasms; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron; Models, Molecular; Oxidation-Reduction; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
The Protective Role of Heme Oxygenase-1 in Atherosclerotic Diseases.
Topics: Animals; Atherosclerosis; Biliverdine; Carbon Monoxide; Coronary Artery Disease; Heme; Heme Oxygenase-1; Humans; Iron; Peripheral Arterial Disease; Reactive Oxygen Species | 2019 |
The Neuroprotective and Neurodegeneration Effects of Heme Oxygenase-1 in Alzheimer's Disease.
Topics: Alzheimer Disease; Bilirubin; Biliverdine; Brain; Heme; Heme Oxygenase-1; Humans; Iron; Neurodegenerative Diseases; Neuroprotection; Oxidation-Reduction; Oxidative Stress; Synapses | 2020 |
The Protective Role of the Heme Catabolic Pathway in Hepatic Disorders.
Topics: Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Liver Diseases | 2021 |
The different facets of heme-oxygenase 1 in innate and adaptive immunity.
Topics: Adaptive Immunity; Anti-Inflammatory Agents; Antioxidants; Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Immunity, Innate; Inflammation Mediators; Iron; Reactive Oxygen Species; Transcription Factors | 2022 |
Novel Function for Bilirubin as a Metabolic Signaling Molecule: Implications for Kidney Diseases.
Topics: Bilirubin; Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Humans; Kidney Diseases; PPAR alpha; Transcription Factors | 2022 |
Heme Oxygenase-1 as Therapeutic Target for Diabetic Foot Ulcers.
Topics: Anti-Inflammatory Agents; Antioxidants; Biliverdine; Carbon Monoxide; Diabetes Mellitus; Diabetic Foot; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron | 2022 |
Biliverdin as a disease-modifying agent: An integrated viewpoint.
Topics: Antioxidants; Bilirubin; Biliverdine; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Kinetics | 2023 |
148 other study(ies) available for heme and biliverdine
| Article | Year |
|---|---|
Electron-transport pathway of the NADH-dependent haem oxygenase system of rat liver microsomal fraction induced by cobalt chloride.
Topics: Animals; Biliverdine; Cobalt; Electron Transport; Enzyme Induction; Heme; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; NAD; NADP; NADPH-Ferrihemoprotein Reductase; Rats | 1979 |
Specific requirement of NADPH-cytochrome c reductase for the microsomal heme oxygenase reaction yielding biliverdin IX alpha.
Topics: Animals; Bilirubin; Biliverdine; Cytochrome Reductases; Heme; Immunoassay; Immunoglobulin G; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Rats | 1979 |
Topological arrangement in microsomal membranes of hepatic haem oxygenase induced by cobalt chloride.
Topics: Animals; Biliverdine; Centrifugation, Isopycnic; Cobalt; Enzyme Induction; Heme; In Vitro Techniques; Intracellular Membranes; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Trypsin | 1979 |
The mechanism of coupled oxidation of octaethylhaem to octaethylbiliverdin [proceedings].
Topics: Bilirubin; Biliverdine; Heme; Oxidation-Reduction | 1978 |
The catalysis of heme degradation by purified NADPH-cytochrome C reductase in the absence of other microsomal proteins.
Topics: Animals; Bile Pigments; Biliverdine; Catalase; Cytochrome Reductases; Epinephrine; Heme; Humans; Microsomes; Microsomes, Liver; NADH, NADPH Oxidoreductases; NADPH-Ferrihemoprotein Reductase; Superoxide Dismutase | 1976 |
Effects of cadmium on microsomal hemoproteins and heme oxygenase in rat liver.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Biliverdine; Cadmium; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochromes; Heme; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Rats; Time Factors | 1977 |
Heme catabolism in human kidneys. Effect of various nephritides.
Topics: Adolescent; Adult; Age Factors; Bilirubin; Biliverdine; Female; Heme; Hemoglobins; Humans; Kidney; Kidney Cortex; Kidney Diseases; Kidney Medulla; L-Lactate Dehydrogenase; Male; Middle Aged; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Reticulocytes | 1977 |
The role of iron in haem degradation [proceedings].
Topics: Bilirubin; Biliverdine; Chemical Phenomena; Chemistry; Heme; Iron; Kinetics; Porphyrins | 1977 |
Bile-pigment isomers from degradation of haemoglobin M Iwate [proceedings].
Topics: Bilirubin; Biliverdine; Heme; Hemoglobin M; Hemoglobins, Abnormal; Humans; Oxidation-Reduction | 1977 |
Induction of globin mRNA accumulation by hemin in cultured erythroleukemic cells.
Topics: Aminolevulinic Acid; Biliverdine; Cell Line; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Erythropoiesis; Globins; Heme; Hemin; Hemoglobins; Kinetics; Porphobilinogen; RNA, Messenger; RNA, Neoplasm | 1976 |
Stereospecific haem cleavage. A model for the formation of bile-pigment isomers in vivo and in vitro.
Topics: Animals; Bilirubin; Biliverdine; Binding Sites; Electron Transport; Heme; Humans; Iron; Models, Chemical; Oxidation-Reduction; Oxygen; Protein Binding; Stereoisomerism | 1976 |
Methine bridge selectivity in haem-cleavage reactions: relevance to the mechanism of haem catabolism.
Topics: Animals; Biliverdine; Binding Sites; Cytochrome P-450 Enzyme System; Heme; Hemeproteins; Humans; Isomerism; Microsomes; Myoglobin; Oxygen; Protein Binding | 1976 |
Intermediates in haem degradation.
Topics: Animals; Bile Pigments; Bilirubin; Biliverdine; Chromatography, Gas; Heme; Mass Spectrometry; Structure-Activity Relationship; Temperature | 1976 |
The enzymatic conversion of heme to bilirubin in vivo.
Topics: Animals; Bile Pigments; Bilirubin; Biliverdine; Chemical Phenomena; Chemistry; Heme; Humans; Microsomes, Liver; Mitochondria, Liver; NADH, NADPH Oxidoreductases; Protoporphyrins | 1976 |
The distinguished lecture: Pyrrolic victories.
Topics: Animals; Bilirubin; Biliverdine; Heme; Hemin; Humans; Microsomes; Oxygenases; Protoporphyrins; Pyrroles; Stereoisomerism | 1976 |
Enzymatic formation of bilirubin and its regulation.
Topics: Animals; Bile Pigments; Bilirubin; Biliverdine; Erythrocyte Aging; Heme; Hemoglobins; Humans; Microsomes; Mixed Function Oxygenases; Oxidoreductases; Rats; Spleen | 1976 |
Bone marrow: its contribution to heme catabolism.
Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Sideroblastic; Biliverdine; Bone Marrow; Heme; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Microsomes; NADH, NADPH Oxidoreductases; Oxygenases | 1976 |
Bilirubin inhibits the activation of superoxide-producing NADPH oxidase in a neutrophil cell-free system.
Topics: Animals; Bilirubin; Biliverdine; Cell Membrane; Cell-Free System; Cytosol; Heme; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Protoporphyrins; Superoxides; Swine; Urobilin | 1991 |
Control of cytochromes P450 expression in Gunn rat liver: implication of the intracellular heme pool.
Topics: Animals; Biliverdine; Cytochrome P-450 Enzyme System; Heme; Heme Oxygenase (Decyclizing); Male; Methylcholanthrene; Microsomes, Liver; Rats; Rats, Gunn; Tryptophan Oxygenase | 1991 |
Enzymic conversion of alpha-oxyprotohaem IX into biliverdin IX alpha by haem oxygenase.
Topics: Animals; Biliverdine; Cattle; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Kinetics; NADP; NADPH-Ferrihemoprotein Reductase; Spectrum Analysis; Spleen | 1990 |
Heme catabolism in cultured hepatocytes: evidence that heme oxygenase is the predominant pathway and that a proportion of synthesized heme is converted rapidly to biliverdin.
Topics: Animals; Bilirubin; Biliverdine; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Liver; Mephenytoin; Mixed Function Oxygenases | 1989 |
Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase.
Topics: Animals; Bilirubin; Biliverdine; Cytochrome P-450 Enzyme System; Cytochromes; Heme; Heme Oxygenase (Decyclizing); Isoenzymes; Liver; Metalloporphyrins; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protoporphyrins; Rats; Spectrophotometry | 1988 |
On the mechanism of the chemical and enzymic oxygenations of alpha-oxyprotohemin IX to Fe.biliverdin IX alpha.
Topics: Apoproteins; Bilirubin; Biliverdine; Chemical Phenomena; Chemistry, Physical; Heme; Hemin; Magnetic Resonance Spectroscopy; Myoglobin; Oxidation-Reduction; Oxygen | 1986 |
High-performance liquid chromatographic separation and quantitation of tetrapyrroles from biological materials.
Topics: Animals; Bilirubin; Biliverdine; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Heme; Liver; Male; Porphyrins; Pyrroles; Rats; Rats, Inbred Strains; Tetrapyrroles | 1986 |
The chemical and enzymatic oxidation of hematohemin IX. Identification of hematobiliverdin IX alpha as the sole product of the enzymatic oxidation.
Topics: Animals; Bilirubin; Biliverdine; Chemical Phenomena; Chemistry; Hematoporphyrins; Heme; Heme Oxygenase (Decyclizing); Hemin; Isomerism; Liver; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Spectrophotometry; Substrate Specificity | 1986 |
Characterization of the enzymatic and nonenzymatic peroxidative degradation of iron porphyrins and cytochrome P-450 heme.
Topics: Animals; Bilirubin; Biliverdine; Cytochrome P-450 Enzyme System; Heme; Hydrogen Peroxide; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Porphyrins; Rats; Rats, Inbred Strains | 1985 |
A two-molecule mechanism of haem degradation.
Topics: Bile Pigments; Biliverdine; Heme; Hydrogen Peroxide; Hydrolysis; Models, Chemical; Oxygen; Phenylhydrazines | 1985 |
Urinary excretion of isomers of biliverdin after destruction in vivo of haemoproteins and haemin.
Topics: Animals; Bilirubin; Biliverdine; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Heme; Hemin; Hemoglobins; Isomerism; Myoglobin; Oxidation-Reduction; Phenylhydrazines; Rabbits | 1985 |
A stoichiometric study of heme degradation catalyzed by the reconstituted heme oxygenase system with special consideration of the production of hydrogen peroxide during the reaction.
Topics: Animals; Biliverdine; Biotransformation; Catalase; Cattle; Chemical Phenomena; Chemistry; Cytochrome c Group; Heme; Heme Oxygenase (Decyclizing); Hemin; Horses; Hydrogen Peroxide; Mixed Function Oxygenases; NADP; Oxygen Consumption; Swine | 1983 |
Biosynthesis of phycocyanobilin from exogenous labeled biliverdin in Cyanidium caldarium.
Topics: Bilirubin; Biliverdine; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Cyanobacteria; Heme; Phycobilins; Phycocyanin; Pigments, Biological; Pyrroles; Tetrapyrroles | 1983 |
Methene bridge carbon atom elimination in oxidative heme degradation catalyzed by heme oxygenase and NADPH-cytochrome P-450 reductase.
Topics: Animals; Biliverdine; Bridged-Ring Compounds; Carbon; Carbon Monoxide; Catalysis; Chemical Phenomena; Chemistry; Heme; Heme Oxygenase (Decyclizing); Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Spleen; Swine | 1984 |
Haem degradation in human haemoglobin in vitro. Separation of the contribution of the alpha- and beta-subunits.
Topics: Biliverdine; Heme; Hemoglobins; Humans; Isomerism; Oxidation-Reduction; Protein Conformation | 1984 |
Hepatic heme metabolism: possible role of biliverdin in the regulation of heme oxygenase activity.
Topics: 5-Aminolevulinate Synthetase; Animals; Bilirubin; Biliverdine; Cytochrome P-450 Enzyme Inhibitors; Heme; Heme Oxygenase (Decyclizing); Hemin; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Inbred Strains | 1984 |
Heme oxygenase provides alpha-selectivity to physiological heme degradation.
Topics: Animals; Biliverdine; Cattle; Heme; Heme Oxygenase (Decyclizing); Isomerism; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Spleen; Substrate Specificity | 1982 |
Inability of the NADH-cytochrome b5 reductase system to initiate heme degradation yielding biliverdin IX alpha from the oxygenated form of heme . heme oxygenase complex.
Topics: Animals; Bilirubin; Biliverdine; Binding Sites; Cytochrome Reductases; Cytochrome-B(5) Reductase; Heme; Heme Oxygenase (Decyclizing); Microsomes, Liver; Mixed Function Oxygenases; Protein Binding; Spectrophotometry; Spleen; Swine | 1980 |
Identification of the product of heme degradation catalyzed by the heme oxygenase system as biliverdin IX alpha by reversed-phase high-performance liquid chromatography.
Topics: Animals; Bilirubin; Biliverdine; Catalysis; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Isomerism; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Rats; Spleen; Swine | 1982 |
Heme catabolism in fish. Bile pigments in gallbladder bile of the electric torpedo, Torpedo californicus.
Topics: Animals; Bile; Bilirubin; Biliverdine; Diazonium Compounds; Gallbladder; Guinea Pigs; Heme; Pigments, Biological; Rats; Rats, Inbred Strains; Spectrophotometry; Torpedo | 1982 |
Haem disorder in reconstituted human haemoglobin.
Topics: Ascorbic Acid; Biliverdine; Heme; Hemoglobin A; Humans; Isomerism; Methemoglobin; Oxidation-Reduction; Protein Conformation | 1982 |
The isomeric biliverdins from ring-cleavage of deuteroporphyrin-IX.
Topics: Bilirubin; Biliverdine; Chemical Phenomena; Chemistry; Deuteroporphyrins; Heme; Isomerism; Magnetic Resonance Spectroscopy; Porphyrins | 1980 |
Mitogenic and co-mitogenic properties of hemin.
Topics: Adult; Aminolevulinic Acid; Animals; Biliverdine; Cattle; Concanavalin A; Heme; Hemin; Horses; Humans; Immunity, Cellular; Lymphocyte Activation; Middle Aged; Mitogens; Protoporphyrins; Thymidine | 1981 |
High-performance liquid chromatographic separation and quantification of the four biliverdin dimethyl ester isomers of the IX series.
Topics: Bilirubin; Biliverdine; Chromatography, High Pressure Liquid; Heme; Isomerism; Spectrophotometry; Structure-Activity Relationship | 1980 |
Nature of the iron requirement for chick embryo cells cultured in the presence of horse serum.
Topics: Animals; Bilirubin; Biliverdine; Cell Division; Cells, Cultured; Chick Embryo; Culture Media; Ferrous Compounds; Heme; Hemin; Hemoglobins; Horses; Iron; Kinetics; Protoporphyrins; Transferrin | 1980 |
The aurea and yellow-green-2 mutants of tomato are deficient in phytochrome chromophore synthesis.
Topics: Biliverdine; Heme; Mutation; Solanum lycopersicum | 1996 |
Oxidation of the meso-methylmesoheme regioisomers by heme oxygenase. Electronic control of the reaction regiospecificity.
Topics: Ascorbic Acid; Biliverdine; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Isomerism; Mesoporphyrins; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Spectrophotometry, Atomic | 1996 |
Aryl hydrocarbon receptor-dependent induction of cyp1a1 by bilirubin in mouse hepatoma hepa 1c1c7 cells.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Bilirubin; Biliverdine; Cytochrome P-450 CYP1A1; DNA-Binding Proteins; Enzyme Induction; Gene Expression Regulation, Enzymologic; Genes, Reporter; Heme; Hemin; Liver Neoplasms, Experimental; Mice; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Synthesis Inhibitors; Receptors, Aryl Hydrocarbon; RNA, Messenger; Transcription Factors; Tumor Cells, Cultured | 1997 |
Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. Molecular linkage between heme catabolism and neuroendocrine function.
Topics: Animals; Arginine Vasopressin; Bilirubin; Biliverdine; Carbon Monoxide; Enzyme Activation; Heme; Heme Oxygenase (Decyclizing); Hemin; Hypothalamus; In Vitro Techniques; Male; Neurosecretory Systems; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Wistar | 1997 |
Carbon monoxide stimulates the apical 70-pS K+ channel of the rat thick ascending limb.
Topics: Animals; Biliverdine; Carbon Monoxide; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Kidney; Lysine; Male; NADP; Patch-Clamp Techniques; Porphyrins; Potassium Channels; Rats; Rats, Sprague-Dawley; RNA | 1999 |
Coupled oxidation of heme covalently attached to cytochrome b562 yields a novel biliprotein.
Topics: Arginine; Bacterial Proteins; Biliverdine; Cloning, Molecular; Cysteine; Cytochrome b Group; Escherichia coli; Escherichia coli Proteins; Heme; Histidine; Hydrolysis; Methionine; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Pyrroles; Tetrapyrroles | 1999 |
Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B).
Topics: Aerobiosis; Biliverdine; Flavins; FMN Reductase; Heme; Humans; Kinetics; Models, Chemical; NADH, NADPH Oxidoreductases; NADP; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Stereoisomerism; Substrate Specificity | 2000 |
Reaction intermediates and single turnover rate constants for the oxidation of heme by human heme oxygenase-1.
Topics: Animals; Biliverdine; Ferric Compounds; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Kinetics; Liver; Membrane Proteins; Models, Chemical; Rats; Spectrometry, Fluorescence; Temperature; Time Factors | 2000 |
Influence of bilirubin and other antioxidants on nitrergic relaxation in the pig gastric fundus.
Topics: Aminoquinolines; Animals; Antioxidants; Bilirubin; Biliverdine; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; Hematinics; Heme; Heme Oxygenase (Decyclizing); Hydroquinones; Hydroxocobalamin; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Stomach; Swine | 2000 |
Identification of the proximal ligand His-20 in heme oxygenase (Hmu O) from Corynebacterium diphtheriae. Oxidative cleavage of the heme macrocycle does not require the proximal histidine.
Topics: Bacterial Proteins; Biliverdine; Carbon Monoxide; Catalytic Domain; Chromatography, High Pressure Liquid; Corynebacterium diphtheriae; Electrophoresis, Polyacrylamide Gel; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Histidine; Humans; Hydroxylation; Ligands; Membrane Proteins; Models, Chemical; Mutagenesis, Site-Directed; Oxidation-Reduction; Spectrophotometry, Atomic; Spectrum Analysis, Raman; Structure-Activity Relationship | 2000 |
Analysis of the optical properties of bile.
Topics: Bile; Bilirubin; Biliverdine; Fiber Optic Technology; Heme; Humans; Hydrogen-Ion Concentration; Optical Fibers; Reproducibility of Results; Spectrophotometry; Stomach Diseases | 2000 |
Separation and identification of the regioisomers of verdoheme by reversed-phase ion-pair high-performance liquid chromatography, and characterization of their complexes with heme oxygenase.
Topics: Ascorbic Acid; Biliverdine; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase (Decyclizing); Hemin; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Oxygen; Pyridines; Stereoisomerism | 2000 |
Turning green to gold.
Topics: Animals; Antioxidants; Bilirubin; Biliverdine; Binding Sites; Coenzymes; Crystallography, X-Ray; Heme; Humans; Models, Molecular; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation; Rats; Stereoisomerism; Substrate Specificity | 2001 |
Crystal structure of rat biliverdin reductase.
Topics: Amino Acid Sequence; Animals; Biliverdine; Binding Sites; Crystallography, X-Ray; Heme; Kinetics; Models, Molecular; Molecular Sequence Data; NAD; NADP; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Protein Structure, Tertiary; Rats; Sequence Alignment; Zinc | 2001 |
Homologues of neisserial heme oxygenase in gram-negative bacteria: degradation of heme by the product of the pigA gene of Pseudomonas aeruginosa.
Topics: Amino Acid Sequence; Bacterial Proteins; Biliverdine; Genetic Complementation Test; Heme; Heme Oxygenase (Decyclizing); Hydrogen Peroxide; Models, Chemical; Molecular Sequence Data; Mutation; Neisseria meningitidis; Pseudomonas aeruginosa; Pseudomonas putida; Sequence Homology, Amino Acid; Species Specificity | 2001 |
Oxidation of heme to beta- and delta-biliverdin by Pseudomonas aeruginosa heme oxygenase as a consequence of an unusual seating of the heme.
Topics: Biliverdine; Catalysis; Heme; Heme Oxygenase (Decyclizing); Histidine; Isomerism; Models, Molecular; Mutagenesis; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Polymerase Chain Reaction; Protein Conformation; Pseudomonas aeruginosa; Spectrum Analysis, Raman | 2002 |
Expression and characterization of cyanobacterium heme oxygenase, a key enzyme in the phycobilin synthesis. Properties of the heme complex of recombinant active enzyme.
Topics: Amino Acid Sequence; Animals; Ascorbic Acid; Biliverdine; Catalysis; Cyanobacteria; Electron Spin Resonance Spectroscopy; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Histidine; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Phycobilins; Phycocyanin; Pyrroles; Rats; Sequence Homology, Amino Acid; Tetrapyrroles | 2003 |
Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization.
Topics: Animals; Biliverdine; Calcium Signaling; Carbon Monoxide; Cell Membrane; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heme; Heme Oxygenase (Decyclizing); Large-Conductance Calcium-Activated Potassium Channels; Lysine; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Ryanodine; Vascular Resistance; Vasodilation | 2003 |
Coupled oxidation vs heme oxygenation: insights from axial ligand mutants of mitochondrial cytochrome b5.
Topics: Animals; Biliverdine; Catalase; Cytochromes b5; Electron Spin Resonance Spectroscopy; Heme; Hydrogen Peroxide; Mitochondria; Mutagenesis, Site-Directed; Oxidation-Reduction; Rats | 2003 |
Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate. Conformational change of the distal helix during the heme cleavage reaction.
Topics: Animals; Biliverdine; Crystallography, X-Ray; Heme; Heme Oxygenase (Decyclizing); Hydrogen Bonding; Hydrolysis; Iron Chelating Agents; Models, Molecular; Protein Conformation; Rats | 2003 |
Stereoselectivity of each of the three steps of the heme oxygenase reaction: hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin.
Topics: Animals; Biliverdine; Carbon Monoxide; Ferrous Compounds; Heme; Heme Oxygenase (Decyclizing); Hemin; Hydroxylation; Oxidation-Reduction; Rats; Spectrophotometry; Stereoisomerism | 2003 |
STUDIES ON HEME ALPHA-METHENYL OXYGENASE. I. THE ENZYMATIC CONVERSION OF PYRIDINE-HEMICHROMOGEN AND HEMOGLOBIN-HAPTOGLOBIN INTO A POSSIBLE PRECURSOR OF BILIVERDIN.
Topics: Animals; Bile Pigments; Biliverdine; Cattle; Chelating Agents; Chromatography; Guinea Pigs; Haptoglobins; Heme; Heme Oxygenase (Decyclizing); Hemoglobins; Liver; NADP; Oxygenases; Polarography; Pyridines; Research; Spectrophotometry; Sulfhydryl Compounds | 1963 |
STUDIES ON HEME ALPHA-METHENYL OXYGENASE. II. THE ISOLATION AND CHARACTERIZATION OF THE FINAL REACTION PRODUCT, A POSSIBLE PRECURSOR OF BILIVERDIN.
Topics: Bile Pigments; Biliverdine; Chromatography; Heme; Heme Oxygenase (Decyclizing); Oxygenases; Pigments, Biological; Porphyrins; Pyridines; Research; Spectrophotometry | 1963 |
Heme oxygenase in Candida albicans is regulated by hemoglobin and is necessary for metabolism of exogenous heme and hemoglobin to alpha-biliverdin.
Topics: Amino Acid Sequence; Animals; Biliverdine; Candida albicans; Chromatography, High Pressure Liquid; Cobalt; DNA, Complementary; Gene Expression Regulation, Enzymologic; Genes, Reporter; Heme; Heme Oxygenase (Decyclizing); Hemin; Hemoglobins; Humans; Hydrolysis; Iron; Luciferases; Mice; Models, Chemical; Molecular Sequence Data; Mutation; Plasmids; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA; RNA, Messenger; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Transcription, Genetic; Trypanosoma brucei brucei; Virulence | 2004 |
Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts.
Topics: Animals; Biliverdine; Cell Movement; DNA-Binding Proteins; Graft Survival; Heart Transplantation; Heme; Interleukin-2; Isoantigens; Lymphocyte Activation; Mice; NF-kappa B; NFATC Transcription Factors; Nuclear Proteins; T-Lymphocytes; Transcription Factors; Transplantation Tolerance | 2004 |
Crystal structure of human heme oxygenase-1 in a complex with biliverdin.
Topics: Animals; Biliverdine; Binding Sites; Catalysis; Computer Simulation; Crystallization; Crystallography, X-Ray; Ferric Compounds; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Macromolecular Substances; Membrane Proteins; Models, Molecular; Protein Binding; Protein Structure, Secondary; Rats | 2004 |
Formation of a highly oxidized iron biliverdin complex upon treatment of a five-coordinate verdoheme with dioxygen.
Topics: Biliverdine; Heme; Indicators and Reagents; Iron; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Oxygen | 2004 |
Human heme oxygenase oxidation of 5- and 15-phenylhemes.
Topics: Animals; Ascorbic Acid; Benzoic Acid; Biliverdine; Carbon Monoxide; Chromatography, High Pressure Liquid; Chromatography, Liquid; Crystallography, X-Ray; Electrons; Esters; Heme; Heme Oxygenase (Decyclizing); Horses; Humans; Ions; Lysine; Mass Spectrometry; Methionine; Models, Chemical; Models, Molecular; Myoglobin; NADPH-Ferrihemoprotein Reductase; Oxidoreductases Acting on CH-CH Group Donors; Oxygen; Spectrophotometry; Stereoisomerism; Time Factors; Ultraviolet Rays | 2004 |
The heme oxygenase(s)-phytochrome system of Pseudomonas aeruginosa.
Topics: Ascorbic Acid; Biliverdine; Catalysis; Ferredoxins; Heme; Heme Oxygenase (Decyclizing); Hydroxylation; Nuclear Magnetic Resonance, Biomolecular; Phytochrome; Pseudomonas aeruginosa | 2004 |
Characterization of a heme oxygenase of Clostridium tetani and its possible role in oxygen tolerance.
Topics: Biliverdine; Cloning, Molecular; Clostridium tetani; Escherichia coli; Gene Expression; Gene Expression Profiling; Genes, Bacterial; Heme; Heme Oxygenase (Decyclizing); Oxygen; Peroxidases; Recombinant Proteins; RNA, Bacterial; RNA, Messenger; Superoxide Dismutase | 2004 |
Why heme needs to be degraded to iron, biliverdin IXalpha, and carbon monoxide?
Topics: Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Hemoglobins; Humans; Iron; Isoenzymes | 2004 |
Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage.
Topics: Biliverdine; Catalysis; Crystallography; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron; Magnetic Resonance Spectroscopy; Membrane Proteins; Models, Molecular; Nitric Oxide; Protein Conformation; Spectrophotometry | 2004 |
Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant.
Topics: Ascorbic Acid; Biliverdine; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Electrons; Heme; Heme Oxygenase (Decyclizing); Humans; Hydrogen Bonding; Models, Chemical; Mutation; NADP; Oxygen; Protein Binding; Protein Conformation; Spectrophotometry; Superoxide Dismutase; Ultraviolet Rays | 2005 |
Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.
Topics: Amidines; Animals; Benzylamines; Biliverdine; Carbon Monoxide; Chromatography, High Pressure Liquid; Enzyme Activation; Enzyme Inhibitors; Heme; Horses; Humans; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ornithine; Spectrometry, Mass, Electrospray Ionization | 2005 |
Protein expressed by the ho2 gene of the cyanobacterium Synechocystis sp. PCC 6803 is a true heme oxygenase. Properties of the heme and enzyme complex.
Topics: Amino Acid Sequence; Ascorbic Acid; Bacterial Proteins; Biliverdine; Electron Spin Resonance Spectroscopy; Heme; Heme Oxygenase (Decyclizing); Hemin; Hydrogen Peroxide; Molecular Sequence Data; NADP; Sequence Alignment; Spectrophotometry; Synechocystis | 2005 |
Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.
Topics: Acetylcysteine; Apoptosis; Apoptosis Regulatory Proteins; Arsenites; Biliverdine; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Cell Survival; Cytochromes c; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Silencing; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Luciferases; Membrane Glycoproteins; Membrane Proteins; Oligonucleotides; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; Oxygen; Phosphorylation; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Retroviridae; RNA, Messenger; RNA, Small Interfering; Serine; Sodium Compounds; Threonine; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2005 |
O(2)- and H(2)O(2)-dependent verdoheme degradation by heme oxygenase: reaction mechanisms and potential physiological roles of the dual pathway degradation.
Topics: Animals; Biliverdine; Catalysis; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase-1; Hydrogen Peroxide; Iron; Mass Spectrometry; Mutagenesis, Site-Directed; Oxidants; Oxidation-Reduction; Oxygen; Rats; Signal Transduction | 2005 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors | 2006 |
A heme-degradation pathway in a blood-sucking insect.
Topics: Animals; Biliverdine; Catalysis; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase (Decyclizing); Hemoglobins; Hydrolysis; Models, Chemical; Oxidative Stress; Porphyrins; Rhodnius; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2006 |
Heme oxygenase induction and biliverdin excretion: implications for the bile fluorescence biomarker.
Topics: Animals; Benzo(a)pyrene; Bile; Biliverdine; Biomarkers; Cadmium; Camphanes; Chlorophenols; Enzyme Induction; Fluorescence; Heme; Heme Oxygenase (Decyclizing); Ictaluridae; Liver; Water Pollutants, Chemical | 2006 |
Theoretical investigations of the reactivity of verdoheme analogues: opening of the planar macrocycle by amide, dimethyl amide, and hydroxide nucleophiles to form helical biliverdin type complexes.
Topics: Amides; Biliverdine; Binding Sites; Heme; Hydroxides; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Structure, Tertiary; Zinc Compounds | 2006 |
Carbon monoxide and biliverdin prevent endothelial cell sloughing in rats with type I diabetes.
Topics: Animals; Biliverdine; Carbon Monoxide; Cell Aggregation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Dinoprost; Endothelial Cells; Endothelium, Vascular; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Organometallic Compounds; Protective Agents; Rats | 2006 |
Carbon monoxide: from the origin of life to molecular medicine.
Topics: Animals; Anti-Inflammatory Agents; Biliverdine; Carbon Monoxide; Colitis; Ferritins; Heme; Heme Oxygenase-1; Humans; Models, Biological | 2006 |
The hmuQ and hmuD genes from Bradyrhizobium japonicum encode heme-degrading enzymes.
Topics: Amino Acid Sequence; Bacterial Proteins; Biliverdine; Bradyrhizobium; Brucella melitensis; Computational Biology; Corynebacterium; Genes, Bacterial; Genetic Complementation Test; Genome, Bacterial; Heme; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Protein Binding; Recombinant Proteins; Sequence Homology, Amino Acid; Spectrum Analysis; Staphylococcus aureus | 2006 |
Role of the peripheral heme oxygenase-carbon monoxide pathway on the nociceptive response of rats to the formalin test: evidence for a cGMP signaling pathway.
Topics: Animals; Biliverdine; Carbon Monoxide; Cyclic GMP; Deferoxamine; Deuteroporphyrins; Heme; Heme Oxygenase (Decyclizing); Iron Chelating Agents; Lysine; Male; Pain; Pain Measurement; Rats; Rats, Wistar; Signal Transduction | 2007 |
Theoretical investigations of the hydrolysis pathway of verdoheme to biliverdin.
Topics: Biliverdine; Computer Simulation; Heme; Hydrolysis; Hydroxides; Iron; Models, Molecular; Molecular Structure; Oxidation-Reduction | 2007 |
X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase.
Topics: Animals; Biliverdine; Binding Sites; Crystallography, X-Ray; Dioxolanes; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Imidazoles; Isoenzymes; Models, Molecular; Rats | 2007 |
Biglutaminyl-biliverdin IX alpha as a heme degradation product in the dengue fever insect-vector Aedes aegypti.
Topics: Aedes; Animals; Bile Pigments; Biliverdine; Dengue; Heme; Insect Proteins; Insect Vectors; Models, Molecular; Molecular Sequence Data; Pigments, Biological | 2007 |
The hydrogen-bonding network in heme oxygenase also functions as a modulator of enzyme dynamics: chaotic motions upon disrupting the H-bond network in heme oxygenase from Pseudomonas aeruginosa.
Topics: Base Sequence; Biliverdine; Catalysis; Crystallography, X-Ray; Heme; Heme Oxygenase (Decyclizing); Hydrogen Bonding; Hydrogen Peroxide; Hydroxylation; Ligands; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Protein Binding; Protein Conformation; Pseudomonas aeruginosa; Spectrum Analysis | 2007 |
Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid.
Topics: Allyl Compounds; Ascorbic Acid; Biliverdine; Catalysis; Heme; Heme Oxygenase (Decyclizing); Mass Spectrometry; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Pseudomonas aeruginosa | 2008 |
Noninnocent effect of axial ligand on the heme degradation process: a theoretical approach to hydrolysis pathway of verdoheme to biliverdin.
Topics: Biliverdine; Heme; Hydrolysis; Models, Molecular; Spin Labels | 2008 |
Implication for using heme methyl hyperfine shifts as indicators of heme seating as related to stereoselectivity in the catabolism of heme by heme oxygenase: in-plane heme versus axial his rotation.
Topics: Biliverdine; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase (Decyclizing); Hemin; Humans; Magnetic Resonance Spectroscopy; Mutation; Stereoisomerism; Substrate Specificity | 2008 |
Expression of the phytochrome operon in Pseudomonas aeruginosa is dependent on the alternative sigma factor RpoS.
Topics: Biliverdine; Gene Expression Regulation, Bacterial; Heme; Heme Oxygenase (Decyclizing); Operon; Phytochrome; Pseudomonas aeruginosa; Quorum Sensing; Regulon; Sigma Factor | 2008 |
Alkyl peroxides reveal the ring opening mechanism of verdoheme catalyzed by heme oxygenase.
Topics: Biliverdine; Catalysis; Heme; Heme Oxygenase (Decyclizing); Molecular Structure; Peroxides | 2008 |
Isoporphyrin intermediate in heme oxygenase catalysis. Oxidation of alpha-meso-phenylheme.
Topics: Biliverdine; Carbon Monoxide; Catalysis; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase-1; Humans; Hydrogen Peroxide; Iron; NADP; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization; Superoxides | 2008 |
A sample extraction and chromatographic strategy for increasing LC/MS detection coverage of the erythrocyte metabolome.
Topics: Atmospheric Pressure; Biliverdine; Chromatography, Liquid; Computational Biology; Erythrocytes; Heme; Hydrogen-Ion Concentration; Mass Spectrometry; Metabolism | 2008 |
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on heme oxygenase-1, biliverdin IXalpha reductase and delta-aminolevulinic acid synthetase 1 in rats with wild-type or variant AH receptor.
Topics: 5-Aminolevulinate Synthetase; Animals; Biliverdine; Body Weight; Cloning, Molecular; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Female; Heme; Heme Oxygenase-1; Liver; Oxidoreductases Acting on CH-CH Group Donors; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger | 2008 |
Heme oxygenase-1: from biology to therapeutic potential.
Topics: Animals; Bilirubin; Biliverdine; Carbon Monoxide; Disease; Enzyme Induction; Evolution, Molecular; Heme; Heme Oxygenase-1; Homeostasis; Humans; Models, Molecular; Protein Structure, Tertiary | 2009 |
Verdoheme formation in Proteus mirabilis catalase.
Topics: Biliverdine; Catalase; Crystallography, X-Ray; Edetic Acid; Heme; Kinetics; Metals; Mutant Proteins; NADP; Oxidation-Reduction; Peracetic Acid; Protein Structure, Secondary; Proteus mirabilis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Static Electricity | 2009 |
Metabolism of haem in Caco-2 cells.
Topics: Bile Pigments; Bilirubin; Biliverdine; Caco-2 Cells; Dose-Response Relationship, Drug; Heme; Humans; Intestinal Mucosa | 2010 |
Theoretical investigation of the ring opening process of verdoheme to biliverdin in the presence of dioxygen.
Topics: Biliverdine; Electrons; Heme; Imidazoles; Iron; Models, Molecular; Oxygen; Protons; Solvents; Surface Properties; Thermodynamics | 2010 |
Human heme oxygenase-1 efficiently catabolizes heme in the absence of biliverdin reductase.
Topics: Animals; Bilirubin; Biliverdine; Binding Sites; Catalase; Catalysis; Ferrozine; Heme; Heme Oxygenase-1; Humans; Hydrogen-Ion Concentration; NADPH-Ferrihemoprotein Reductase; Oxidoreductases Acting on CH-CH Group Donors; Rabbits | 2010 |
Glutathionyl-biliverdin IXα, a new heme catabolite in a marine annelid: Sex and cell specific accumulation.
Topics: Animals; Biliverdine; Female; Glutathione; Heme; Male; Polychaeta; Sex Characteristics | 2011 |
Immunoregulatory properties of heme oxygenase-1.
Topics: Animals; Anti-Inflammatory Agents; Autoimmunity; Biliverdine; Carbon Monoxide; Cell Culture Techniques; Cytokines; Heme; Heme Oxygenase-1; Humans; Hypersensitivity; Immune System Diseases; Mice; Oxidative Stress; Rats; Suppressor Factors, Immunologic | 2011 |
Heme oxygenase system in hepatic ischemia-reperfusion injury.
Topics: Adaptive Immunity; Animals; Antioxidants; Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Humans; Immunomodulation; Iron; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neutrophils; Reperfusion Injury | 2010 |
Isolation and characterization of a heme oxygenase-1 gene from Chinese cabbage.
Topics: Amino Acid Sequence; Biliverdine; Brassica rapa; Chloroplasts; Cloning, Molecular; Escherichia coli; Heat-Shock Response; Heme; Heme Oxygenase-1; Hemin; Hydrogen Peroxide; Molecular Sequence Data; Phylogeny; Sequence Alignment; Sequence Analysis, DNA | 2012 |
Isolation and characterization of free haem from the shell gland of quail and hen.
Topics: Animals; Biliverdine; Chickens; Chromatography, High Pressure Liquid; Coturnix; Egg Shell; Heme; Protoporphyrins; Spectrometry, Mass, Electrospray Ionization | 2012 |
Variable composition of heme oxygenases with different regiospecificities in Pseudomonas species.
Topics: Biliverdine; Computational Biology; Heme; Heme Oxygenase (Decyclizing); Hydrogen-Ion Concentration; Isomerism; Kinetics; Protein Binding; Pseudomonas; Pseudomonas aeruginosa; Recombinant Proteins; Temperature | 2012 |
Spectroscopic detection and quantification of heme and heme degradation products.
Topics: Animals; Bilirubin; Biliverdine; Equipment Design; Heme; Hemin; Horses; Limit of Detection; Microfluidic Analytical Techniques; Models, Molecular; Myoglobin; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman | 2012 |
Heme modulates smooth muscle cell proliferation and migration via NADPH oxidase: a counter-regulatory role for heme oxygenase system.
Topics: Animals; Biliverdine; Carbon Monoxide; Cell Line; Cell Movement; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; NF-kappa B; Rats; Reactive Oxygen Species; Signal Transduction; Time Factors | 2012 |
Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum.
Topics: Amino Acid Sequence; Bilirubin; Biliverdine; Chromatography, High Pressure Liquid; Erythrocytes; Heme; Heme Oxygenase (Decyclizing); Humans; Malaria, Falciparum; Microscopy, Fluorescence; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmodium falciparum; Protein Binding; Proteolysis; Protoporphyrins; Protozoan Proteins; Sequence Homology, Amino Acid; Spectrometry, Fluorescence; Tandem Mass Spectrometry | 2012 |
An HPLC method to detect heme oxygenase activity.
Topics: Animals; Bilirubin; Biliverdine; Biological Assay; Catalysis; Cells, Cultured; Chromatography, High Pressure Liquid; Heme; Heme Oxygenase (Decyclizing); Humans; Microsomes; Oxidation-Reduction | 2001 |
PORPHOBILINOGEN DEAMINASE deficiency alters vegetative and reproductive development and causes lesions in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Biliverdine; Chlorophyll; Gene Expression Regulation, Plant; Heme; Hydroxymethylbilane Synthase; Indoleacetic Acids; MADS Domain Proteins; Mutation; Phenotype; Plant Development; Plant Growth Regulators; Plant Leaves; Plants, Genetically Modified; Porphobilinogen; Reproduction | 2013 |
Retrograde bilin signaling enables Chlamydomonas greening and phototrophic survival.
Topics: Bile Pigments; Biliverdine; Biocatalysis; Chlamydomonas reinhardtii; Chlorophyll; Chloroplasts; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Regulatory Networks; Genes, Plant; Heme; Heme Oxygenase (Decyclizing); Iron; Light; Mutation; Oxidoreductases; Phenotype; Phototrophic Processes; Phycobilins; Phycocyanin; Pigmentation; Plants, Genetically Modified; Signal Transduction; Subcellular Fractions | 2013 |
Structures of the substrate-free and product-bound forms of HmuO, a heme oxygenase from corynebacterium diphtheriae: x-ray crystallography and molecular dynamics investigation.
Topics: Biliverdine; Binding Sites; Corynebacterium diphtheriae; Crystallography, X-Ray; Diphtheria; Heme; Heme Oxygenase (Decyclizing); Humans; Hydrogen Bonding; Iron; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Water | 2013 |
Biliverdin's regulation of reactive oxygen species signalling leads to potent inhibition of proliferative and angiogenic pathways in head and neck cancer.
Topics: Animals; Antioxidants; Biliverdine; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Heme; Humans; Mice; Neovascularization, Pathologic; Reactive Oxygen Species; Signal Transduction | 2014 |
Structural and functional characterization of an Isd-type haem-degradation enzyme from Listeria monocytogenes.
Topics: Amino Acid Sequence; Bacterial Outer Membrane Proteins; Biliverdine; Catalysis; Crystallography, X-Ray; Heme; Humans; Listeria monocytogenes; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxygenases | 2014 |
Structure of a novel farnesylated bilin from an insect--formation by α-cleavage of heme A of mitochondrial cytochrome c oxidases?
Topics: Acetylation; Animals; Bile Pigments; Biliverdine; Carrier Proteins; Electron Transport Complex IV; Female; Heme; Insect Proteins; Magnetic Resonance Spectroscopy; Male; Mitochondria; Molecular Structure; Moths; Prenylation; Spectrophotometry | 2014 |
Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin.
Topics: Bacteria; Biliverdine; Carbon Monoxide; Corynebacterium diphtheriae; Enzymes; Heme; Heme Oxygenase (Decyclizing); Hydroxylation; Iron; Neisseriaceae; Oxidation-Reduction; Protein Structure, Tertiary; Pseudomonas aeruginosa; Yin-Yang | 2014 |
Very high-density lipoprotein and vitellin as carriers of novel biliverdins IXα with a farnesyl side-chain presumably derived from heme A in Spodoptera littoralis.
Topics: Animals; Biliverdine; Carrier Proteins; Farnesol; Female; Heme; Hemolymph; Larva; Lipoproteins, HDL; Ovum; Spodoptera; Vitellins | 2016 |
Nucleophilic ring-opening of iron(III)-hydroxy-isoporphyrin.
Topics: Alcohols; Biliverdine; Coordination Complexes; Ferric Compounds; Heme; Magnetic Resonance Spectroscopy; Porphyrins; Quantum Theory | 2016 |
HmuS and HmuQ of Ensifer/Sinorhizobium meliloti degrade heme in vitro and participate in heme metabolism in vivo.
Topics: Bacterial Proteins; Biliverdine; Biocatalysis; Enzyme Induction; Gene Expression; Gene Expression Regulation, Bacterial; Heme; Hemin; Iron; Kinetics; Mixed Function Oxygenases; Sinorhizobium meliloti | 2016 |
In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis.
Topics: Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Bacterial Proteins; Biliverdine; Biocatalysis; Catalase; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Synechocystis | 2016 |
Metabolite-driven Regulation of Heme Uptake by the Biliverdin IXβ/δ-Selective Heme Oxygenase (HemO) of Pseudomonas aeruginosa.
Topics: Amino Acid Substitution; Bacterial Proteins; Biliverdine; Carrier Proteins; Heme; Heme Oxygenase (Decyclizing); Holoenzymes; Iron; Mutation, Missense; Pseudomonas aeruginosa | 2016 |
Structural and functional study of ChuY from Escherichia coli strain CFT073.
Topics: Animals; Biliverdine; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; FMN Reductase; Gene Deletion; Genomics; HEK293 Cells; Heme; Hemin; Homeostasis; Humans; Iron; Mice; NADP; Oxidoreductases Acting on CH-CH Group Donors; Porphyrins; Protein Conformation; Protein Structure, Secondary; RAW 264.7 Cells; Virulence | 2017 |
Tryptophan-Rich Sensory Protein/Translocator Protein (TSPO) from Cyanobacterium Fremyella diplosiphon Binds a Broad Range of Functionally Relevant Tetrapyrroles.
Topics: Amino Acid Sequence; Bacterial Proteins; Bile Pigments; Biliverdine; Binding Sites; Binding, Competitive; Cholesterol; Cyanobacteria; Heme; Membrane Proteins; Mutation; Phylogeny; Porphyrins; Protein Binding; Sequence Homology, Amino Acid; Spectrophotometry; Tetrapyrroles | 2017 |
Impact of higher-order heme degradation products on hepatic function and hemodynamics.
Topics: Acute-On-Chronic Liver Failure; Animals; Bile; Bilirubin; Biliverdine; Cholestasis; Glutathione; Heme; Hemodynamics; Hep G2 Cells; Humans; Hyperbilirubinemia; In Vitro Techniques; Liver; Liver Circulation; Male; Oxidation-Reduction; Pyrroles; Rats; Rats, Wistar | 2017 |
Reaction intermediates in the heme degradation reaction by HutZ from Vibrio cholerae.
Topics: Animals; Ascorbic Acid; Bacterial Proteins; Biliverdine; Heme; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Models, Molecular; Sequence Analysis, Protein; Spectrum Analysis, Raman; Vibrio cholerae | 2017 |
Identification of Genes for Synthesis of the Blue Pigment, Biliverdin IXα, in the Blue Coral Heliopora coerulea.
Topics: Animals; Anthozoa; Biliverdine; Heme; Heme Oxygenase (Decyclizing); Phylogeny; Transcriptome | 2017 |
Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques.
Topics: Animals; Atherosclerosis; Bilirubin; Biliverdine; Biomarkers; Carotid Arteries; Endarterectomy, Carotid; Heme; Hemorrhage; Humans; Mice; Optical Imaging; Plaque, Atherosclerotic; Risk Factors; Spectroscopy, Near-Infrared; Spectrum Analysis, Raman | 2017 |
Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress.
Topics: Animals; Antioxidants; Bilirubin; Biliverdine; Cholesterol Esters; Dimerization; Erythrocytes; Heme; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Oxidoreductases Acting on CH-CH Group Donors; Peroxiredoxins; Sequence Deletion | 2018 |
A novel mechanism of heme degradation to biliverdin studied by QM/MM and QM calculations.
Topics: Biliverdine; Carbon Monoxide; Heme; Heme Oxygenase (Decyclizing); Hydrogen Bonding; Hydroxylation; Iron; Ligands; Molecular Structure; Oxidation-Reduction; Oxygen; Quantum Theory; Water | 2018 |
Hydrogen sulfide bypasses the rate-limiting oxygen activation of heme oxygenase.
Topics: Animals; Biliverdine; Catalysis; Heme; Heme Oxygenase (Decyclizing); Humans; Hydrogen Sulfide; Iron; Oxidation-Reduction; Oxygen; Rats; Reactive Oxygen Species | 2018 |
A Single Mutation in the Mycobacterium tuberculosis Heme-Degrading Protein, MhuD, Results in Different Products.
Topics: Bacterial Proteins; Biliverdine; Carbon Monoxide; Formaldehyde; Heme; Heme Oxygenase (Decyclizing); Models, Molecular; Mutation; Mycobacterium tuberculosis; Protein Conformation | 2019 |
Non-canonical transcriptional regulation of heme oxygenase in Aedes aegypti.
Topics: Aedes; Animals; Antioxidants; Biliverdine; Carbon Monoxide; Down-Regulation; Gene Expression Regulation; Heme; Heme Oxygenase (Decyclizing); Oxidative Stress; Transcription, Genetic | 2019 |
Structure of a
Topics: Bacterial Proteins; Biliverdine; Crystallography, X-Ray; Heme; Humans; Mixed Function Oxygenases; Models, Molecular; Mycobacterium tuberculosis; Point Mutation; Protein Conformation; Substrate Specificity; Tuberculosis | 2019 |
Biochemical characterization of biliverdins IXβ/δ generated by a selective heme oxygenase.
Topics: Biliverdine; Genes, Bacterial; Heme; Heme Oxygenase (Decyclizing); Kinetics; Oxidation-Reduction; Oxidoreductases; Pseudomonas aeruginosa | 2020 |
Divergent erythroid megakaryocyte fates in Blvrb-deficient mice establish non-overlapping cytoprotective functions during stress hematopoiesis.
Topics: Animals; Biliverdine; Cell Lineage; Hematopoiesis; Heme; Megakaryocytes; Mice; Mice, Knockout; Oxidoreductases Acting on CH-CH Group Donors | 2021 |
Molecular Pathways and Pigments Underlying the Colors of the Pearl Oyster
Topics: Animals; Bilirubin; Biliverdine; Color; Gene Expression Profiling; Heme; Melanins; Pigmentation; Pinctada; RNA-Seq; Transcriptome; Uroporphyrins; Vitamin B 12; Xanthine | 2021 |
SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity.
Topics: Antibodies, Monoclonal; Antibodies, Neutralizing; Bilirubin; Biliverdine; COVID-19; Cryoelectron Microscopy; Crystallography, X-Ray; Epitopes; Heme; Humans; Immune Sera; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2021 |
Engineering Bacteria to Monitor the Bleeding of Animals Using Far-Red Fluorescence.
Topics: Animals; Biliverdine; Escherichia coli; Heme; Microscopy, Fluorescence; Zebrafish | 2021 |
Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in human embryonic kidney cells.
Topics: Biliverdine; HEK293 Cells; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Iron; Kidney | 2022 |
Biliverdin regulates NR2E3 and zebrafish retinal photoreceptor development.
Topics: Animals; Biliverdine; Heme; Ligands; Orphan Nuclear Receptors; Photoreceptor Cells; Photoreceptor Cells, Vertebrate; Receptors, Cytoplasmic and Nuclear; Retinal Degeneration; Zebrafish; Zebrafish Proteins | 2022 |
Protective activity of purpurin against d-galactosamine and lipopolysaccharide-induced hepatorenal injury by upregulation of heme oxygenase-1 in the RBC degradation cycle.
Topics: Animals; Anthraquinones; Antioxidants; Biliverdine; Catalase; Cholesterol; Cytochrome P-450 CYP2E1; Female; Ferritins; Food Additives; Galactosamine; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Heme; Heme Oxygenase-1; Hemosiderin; Inflammation; Lipopolysaccharides; Liver; NADP; Rats; Superoxide Dismutase; Transferases; Triglycerides; Up-Regulation | 2022 |
Effects of Heme Site (FA1) Ligands Bilirubin, Biliverdin, Hemin, and Methyl Orange on the Albumin Binding of Site I Marker Warfarin: Complex Allosteric Interactions.
Topics: Bilirubin; Biliverdine; Heme; Hemin; Humans; Ligands; Serum Albumin; Warfarin | 2022 |
Bilirubin is produced nonenzymatically in plants to maintain chloroplast redox status.
Topics: Bilirubin; Biliverdine; Chloroplasts; Heme; Oxidation-Reduction | 2023 |