Compounds > heme
Page last updated: 2024-08-23

heme and bay 58-2667

heme has been researched along with bay 58-2667 in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (50.00)29.6817
2010's10 (45.45)24.3611
2020's1 (4.55)2.80

Authors

AuthorsStudies
Schmidt, P; Schramm, M; Schröder, H; Stasch, JP2
Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F1
Deile, M; H S, AK; Kemp-Harper, B; Knorr, A; Lapp, H; Meurer, S; Müller, H; Müller-Esterl, W; Nedvetskaya, TY; Nedvetsky, PI; Rothkegel, C; Schmidt, HH; Schmidt, PM; Stasch, JP; Taye, A; Tersteegen, A; Turgay, Y1
Genth-Zotz, S; Hink, U; Münzel, T1
Boerrigter, G; Burnett, JC; Cataliotti, A; Costello-Boerrigter, LC; Lapp, H; Stasch, JP1
Boerrigter, G; Burnett, JC2
Garthwaite, J; Mo, E; Roy, B; Vernon, J1
Schmidt, HH; Schmidt, PM; Stasch, JP1
Hoffmann, LS; Keim, Y; Schaefer, S; Schmidt, HH; Schmidt, PM; Stasch, JP1
Baskaran, P; Beuve, A; Dunten, PW; Ma, X; Martin, F; Schaefer, M; Stasch, JP; van den Akker, F1
Ahrens, I; Baumlin, N; Bode, C; Habersberger, J; Peter, K; Qian, H; Schmidt, HH; Smith, BK; Stasch, JP1
Hoffmann, C; Hoffmann, LS; Keim, Y; Schmidt, HH; Schmidt, PM; Stasch, JP1
Marletta, MA; Surmeli, NB1
Barnucz, E; Hegedüs, P; Hirschberg, K; Karck, M; Korkmaz, S; Li, S; Loganathan, S; Mikles, B; Páli, S; Radovits, T; Szabó, G; Weymann, A1
Alisaraie, L; Fu, Y; Tuszynski, JA1
Bantzi, M; Giannis, A; Kumar, V; Marazioti, A; Moschner, J; Papapetropoulos, A; Rekowski, MVW; Spyroulias, GA; van den Akker, F; Zhou, Z1
Bloch, KD; Brouckaert, P; Buys, ES; Cauwels, A; De Cauwer, L; Decaluwe, K; Delanghe, J; Geschka, S; Hochepied, T; Karas, RH; Rogge, E; Sips, P; Stasch, JP; Tainsh, RE; Thoonen, R; Van de Voorde, J; Voet, S; Vuylsteke, M1
Bucci, M; Cirino, G; Esposito, I; Martin, E; Papapetropoulos, A; Sharina, I; Szabo, C; Zhou, Z1
Durgin, BG; Freitag, D; Hafeez, N; Hahn, SA; Mathar, I; Miller, MP; Sandner, P; Schmidt, HM; Straub, AC1
Billings, FT; Dikalov, SI; Hennessy, C; Kimlinger, MJ; Lopez, MG; Mace, EH; No, TJ; Shotwell, MS1

Reviews

2 review(s) available for heme and bay 58-2667

ArticleYear
Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease.
    Cardiovascular drug reviews, 2007,Spring, Volume: 25, Issue:1

    Topics: Animals; Antihypertensive Agents; Benzoates; Cardiovascular Diseases; Cell Adhesion; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heart Failure; Heme; Humans; Hypertension; Hypertension, Pulmonary; Inflammation; Leukocytes; Nitric Oxide; Platelet Aggregation; Pyrazoles; Pyridines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilator Agents

2007
NO- and haem-independent soluble guanylate cyclase activators.
    Handbook of experimental pharmacology, 2009, Issue:191

    Topics: Animals; Benzoates; Cardiovascular Diseases; Clinical Trials as Topic; Drug Delivery Systems; Enzyme Activators; Guanylate Cyclase; Heme; Humans; Nitric Oxide; ortho-Aminobenzoates; Oxidative Stress; Receptors, Cytoplasmic and Nuclear; Risk Factors; Soluble Guanylyl Cyclase; Sulfonamides

2009

Other Studies

20 other study(ies) available for heme and bay 58-2667

ArticleYear
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
    European journal of pharmacology, 2003, May-16, Volume: 468, Issue:3

    Topics: Benzoates; Diethylamines; Enzyme Activation; Guanylate Cyclase; Heme; Morpholines; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Pyrimidines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spectrophotometry, Ultraviolet

2003
Preparation of heme-free soluble guanylate cyclase.
    Protein expression and purification, 2003, Volume: 31, Issue:1

    Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc

2003
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
    European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2

    Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection

2005
Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels.
    The Journal of clinical investigation, 2006, Volume: 116, Issue:9

    Topics: Animals; Benzoates; Blood Pressure; Blood Vessels; Cell Culture Techniques; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; Heme; Oxidation-Reduction; Oxidative Stress; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Swine; Vasodilation

2006
Targeting heme-oxidized soluble guanylate cyclase: solution for all cardiorenal problems in heart failure?
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:5

    Topics: Animals; Benzoates; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; Heart; Heart Failure; Heme; Humans; Kidney; Oxidation-Reduction; Solubility

2007
Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 49, Issue:5

    Topics: Animals; Atrial Natriuretic Factor; Benzoates; Blood Vessels; Cardiovascular System; Dogs; Dose-Response Relationship, Drug; Guanylate Cyclase; Heart Failure; Heme; Kidney; Male; Natriuretic Peptide, Brain; Oxidation-Reduction; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilation

2007
Probing the presence of the ligand-binding haem in cellular nitric oxide receptors.
    British journal of pharmacology, 2008, Volume: 153, Issue:7

    Topics: Animals; Benzoates; Binding Sites; Blood Platelets; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; Drug Delivery Systems; Guanylate Cyclase; Heme; Ligands; Nitric Oxide; Oxidation-Reduction; Phosphorylation; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase

2008
Soluble guanylate cyclase: not a dull enzyme.
    Circulation, 2009, Jun-02, Volume: 119, Issue:21

    Topics: Benzoates; Clinical Trials as Topic; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Heart Failure; Heme; Humans; Morpholines; Nitric Oxide; Pyrazoles; Pyridines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Vasodilator Agents; Vasomotor System

2009
Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
    British journal of pharmacology, 2009, Volume: 157, Issue:5

    Topics: Aequorin; Animals; Benzoates; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Enzyme Stability; Genes, Reporter; Guanylate Cyclase; Heme; Molecular Structure; Mutation; ortho-Aminobenzoates; Oxadiazoles; Oxidation-Reduction; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Structure-Activity Relationship; Sulfonamides; Swine; Transfection

2009
Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.
    The Journal of biological chemistry, 2010, Jul-16, Volume: 285, Issue:29

    Topics: Benzoates; Crystallography, X-Ray; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Models, Molecular; Molecular Mimicry; Mutagenesis; Nitric Oxide; Nostoc; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Structure-Activity Relationship

2010
Measuring oxidative burden and predicting pharmacological response in coronary artery disease patients with a novel direct activator of haem-free/oxidised sGC.
    Atherosclerosis, 2011, Volume: 218, Issue:2

    Topics: Aged; Benzoates; Blood Platelets; Cell Adhesion Molecules; Coronary Artery Disease; Female; Guanylate Cyclase; Heme; Humans; Male; Microfilament Proteins; Middle Aged; Models, Biological; Oxidative Stress; Oxygen; P-Selectin; Phosphoproteins; Phosphorylation

2011
Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Benzoates; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Cysteine; Enzyme Activation; Enzyme Activators; Fluorescence; Fluorescent Dyes; Guanylate Cyclase; Heme; Humans; Molecular Sequence Data; Mutation; Nitric Oxide; Oxadiazoles; Oxazines; Oxidation-Reduction; Protein Engineering; Receptors, Cytoplasmic and Nuclear; Rotenone; Signal Transduction; Soluble Guanylyl Cyclase; Spectrometry, Fluorescence

2011
Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.
    Chembiochem : a European journal of chemical biology, 2012, May-07, Volume: 13, Issue:7

    Topics: Animals; Benzoates; Enzyme Activators; Guanylate Cyclase; Heme; Kinetics; Nitric Oxide; Oxidation-Reduction; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase

2012
Nitric oxide- and heme-independent activation of soluble guanylate cyclase attenuates peroxynitrite-induced endothelial dysfunction in rat aorta.
    Journal of cardiovascular pharmacology and therapeutics, 2013, Volume: 18, Issue:1

    Topics: Animals; Aorta, Thoracic; Benzoates; Cyclic GMP; DNA Breaks; Endothelium, Vascular; Guanylate Cyclase; Heme; In Vitro Techniques; Male; Nitric Oxide; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilation

2013
Dynamic change of heme environment in soluble guanylate cyclase and complexation of NO-independent drug agents with H-NOX domain.
    Chemical biology & drug design, 2013, Volume: 81, Issue:3

    Topics: Amino Acid Sequence; Benzoates; Binding Sites; Catalytic Domain; Guanylate Cyclase; Heme; Humans; Molecular Docking Simulation; Molecular Sequence Data; Nitric Oxide; Protein Structure, Tertiary; Protein Subunits; Receptors, Cytoplasmic and Nuclear; Sequence Alignment; Software; Soluble Guanylyl Cyclase

2013
Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics.
    Journal of medicinal chemistry, 2013, Nov-14, Volume: 56, Issue:21

    Topics: Benzoates; Dose-Response Relationship, Drug; Drug Design; Enzyme Activation; Guanylate Cyclase; Heme; Models, Molecular; Molecular Conformation; Nitric Oxide; Nostoc; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Structure-Activity Relationship

2013
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
    Nature communications, 2015, Oct-07, Volume: 6

    Topics: Animals; Benzoates; Blood Pressure; Cardiovascular System; Gene Knock-In Techniques; Guanylate Cyclase; Heme; Hypertension; Hypotension; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Nitric Oxide; Oxidative Stress; Platelet Aggregation; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tumor Necrosis Factor-alpha

2015
Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide.
    Pharmacological research, 2016, Volume: 111

    Topics: Animals; Aorta, Thoracic; Benzoates; Cells, Cultured; Cystathionine gamma-Lyase; Heme; Hydrogen Sulfide; In Vitro Techniques; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxidation-Reduction; Phenylephrine; Quaternary Ammonium Compounds; Rats; Soluble Guanylyl Cyclase

2016
Loss of smooth muscle CYB5R3 amplifies angiotensin II-induced hypertension by increasing sGC heme oxidation.
    JCI insight, 2019, 10-03, Volume: 4, Issue:19

    Topics: Angiotensin II; Animals; Benzoates; Blood Pressure; Cytochrome-B(5) Reductase; Genotype; Heme; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Nitric Oxide; Oxidation-Reduction; Soluble Guanylyl Cyclase; Transcriptome; Vasodilation

2019
SOLUBLE GUANYLYL CYCLASE ACTIVATION RESCUES HYPEROXIA-INDUCED DYSFUNCTION OF VASCULAR RELAXATION.
    Shock (Augusta, Ga.), 2022, 10-01, Volume: 58, Issue:4

    Topics: Acetylcholine; Animals; Endothelium, Vascular; Heme; Hyperoxia; Mice; Nitric Oxide; Nitroprusside; Oxygen; Soluble Guanylyl Cyclase; Superoxides; Vasodilation; Vasodilator Agents

2022