Compounds > heme
Page last updated: 2024-08-23

heme and aspirin

heme has been researched along with aspirin in 24 studies

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199011 (45.83)18.7374
1990's7 (29.17)18.2507
2000's4 (16.67)29.6817
2010's1 (4.17)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Bridges, KR; Bunn, HF; Cerami, A; Jensen, M; Schmidt, GJ1
DeWitt, DL; Shimokawa, T; Smith, WL1
Andrews, MJ; Armstrong, RL; DeWitt, DL; el-Harith, EA; Kraemer, SA; Smith, WL; Yao, EF1
Kulmacz, RJ; Wu, KK1
Chen, YN; Marnett, LJ1
Barraclough, D; Deacon, M; Lynch, NM; McHutchison, JG; St John, DJ; Young, GP1
Balasubramanian, AS; Boopathy, R1
Rao, GH; White, JG1
Kulmacz, RJ; Lands, WE; Miller, JF1
Buytenhek, M; van der Ouderaa, FJ; van Dorp, DA1
Cohen, I; Glueck, R; Green, D; Ts'ao, CH1
Held, K1
Ahmed, AE; Ghanayem, BI1
Foresti, R; Motterlini, R; Vandegriff, K; Winslow, RM1
Alayash, AI; Darbyshire, JF; Meyer, CA; Osawa, Y1
Baek, HK; Kulmacz, RJ; Tsai, Al; Van Wart, HE; Wei, C1
Burlingame, AL; Friso, G; Lo-Tseng, T; Miranda, JJ; Moore, EG; Patel, MJ; Yu, Z1
Alayash, AI; Mondoro, TH; Ryan, BA; Terle, DA; Vostal, JG1
Abad-Zapatero, C; Fernandez, EJ; Olsen, KW1
Alayash, AI; D'Agnillo, F1
Gonzalez, Y; Harrington, JP; Hirsch, RE1
Bhushan, A; Kaur, P; Sharma, S; Singh, AK; Singh, N; Singh, TP; Sinha, M; Srinivasan, A1
Dong, L; Jurban, BJ; Sharma, NP; Smith, WL1
Ascenzi, P; De Simone, G; di Masi, A1

Reviews

1 review(s) available for heme and aspirin

ArticleYear
Serum Albumin: A Multifaced Enzyme.
    International journal of molecular sciences, 2021, Sep-18, Volume: 22, Issue:18

    Topics: Animals; Antioxidants; Aspirin; Biomarkers; Catalysis; Fructose-Bisphosphate Aldolase; Glucuronidase; Green Chemistry Technology; Heme; Humans; Ions; Ligands; Lipid Peroxidation; Molecular Conformation; Phosphopyruvate Hydratase; Protein Binding; Rats; Reactive Oxygen Species; Serum Albumin, Human

2021

Trials

1 trial(s) available for heme and aspirin

ArticleYear
Gastrointestinal blood loss from a new buffered aspirin (Ostoprin): measurement by radiochromium and Hemoquant techniques.
    Australian and New Zealand journal of medicine, 1989, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Aspirin; Chromium Radioisotopes; Female; Gastrointestinal Hemorrhage; Heme; Humans; Male; Middle Aged; Occult Blood; Osteoarthritis

1989

Other Studies

22 other study(ies) available for heme and aspirin

ArticleYear
The acetylation of hemoglobin by aspirin. In vitro and in vivo.
    The Journal of clinical investigation, 1975, Volume: 56, Issue:1

    Topics: Acetylation; Aspirin; Autoradiography; Binding Sites; Blood Protein Electrophoresis; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Densitometry; Erythrocytes; Heme; Hemoglobins; Hemolysis; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Isoelectric Focusing; Ninhydrin; Oxygen; Serum Albumin

1975
The aspirin and heme binding sites of PGG/H synthase.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1991, Volume: 21A

    Topics: Amino Acid Sequence; Animals; Aspirin; Binding Sites; Cyclooxygenase Inhibitors; Heme; Histidine; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Prostaglandin-Endoperoxide Synthases; Sequence Homology, Nucleic Acid; Serine; Sheep; Species Specificity

1991
The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases.
    The Journal of biological chemistry, 1990, Mar-25, Volume: 265, Issue:9

    Topics: Amino Acid Sequence; Animals; Aspirin; Base Sequence; Binding Sites; Blotting, Western; DNA; Genetic Vectors; Heme; Mice; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Prostaglandin-Endoperoxide Synthases; Restriction Mapping; Sequence Homology, Nucleic Acid; Serine; Sheep

1990
Topographic studies of microsomal and pure prostaglandin H synthase.
    Archives of biochemistry and biophysics, 1989, Feb-01, Volume: 268, Issue:2

    Topics: Animals; Aspirin; Chymotrypsin; Detergents; Endopeptidase K; Globins; Heme; Male; Microsomes; Molecular Weight; Peptide Fragments; Peptide Mapping; Prostaglandin-Endoperoxide Synthases; Protein Conformation; Seminal Vesicles; Serine Endopeptidases; Sheep; Solubility; Structure-Activity Relationship; Trypsin

1989
Heme prosthetic group required for acetylation of prostaglandin H synthase by aspirin.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:11

    Topics: Acetylation; Animals; Apoproteins; Aspirin; Cyclooxygenase Inhibitors; Heme; Prostaglandin-Endoperoxide Synthases; Protein Conformation; Structure-Activity Relationship; Swine; Trypsin

1989
Purification and characterization of sheep platelet cyclo-oxygenase. Acetylation by aspirin prevents haemin binding to the enzyme.
    The Biochemical journal, 1986, Oct-15, Volume: 239, Issue:2

    Topics: Acetylation; Animals; Aspirin; Blood Platelets; Carbohydrates; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Heme; Hemin; Hemoglobins; In Vitro Techniques; Prostaglandin-Endoperoxide Synthases; Sheep

1986
Comparative pharmacology of cyclooxygenase inhibitors on platelet function.
    Prostaglandins, leukotrienes, and medicine, 1985, Volume: 18, Issue:1

    Topics: 2,2'-Dipyridyl; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Docosahexaenoic Acids; Fatty Acids, Unsaturated; Heme; Humans; Ibuprofen; Iron; Platelet Aggregation

1985
Prostaglandin H synthase: an example of enzymic symbiosis.
    Biochemical and biophysical research communications, 1985, Jul-31, Volume: 130, Issue:2

    Topics: Aspirin; Free Radicals; Glutathione Peroxidase; Heme; Models, Chemical; Peroxidases; Prostaglandin-Endoperoxide Synthases

1985
Characterization of prostaglandin H2 synthetase.
    Advances in prostaglandin and thromboxane research, 1980, Volume: 6

    Topics: Acetylation; Amino Acid Sequence; Animals; Aspirin; Heme; Hemeproteins; Iron; Male; Microsomes; Molecular Weight; Prostaglandin-Endoperoxide Synthases; Protein Binding; Seminal Vesicles; Sheep; Spectrophotometry

1980
Hematin: unique effects of hemostasis.
    Blood, 1983, Volume: 61, Issue:2

    Topics: Adult; Aspirin; Blood Coagulation Disorders; Blood Coagulation Tests; Fibrinogen; Glucose; Heme; Hemin; Heparin; Humans; In Vitro Techniques; Male; Platelet Aggregation; Porphyrias

1983
[Conservative therapy of stroke from an internist's viewpoint].
    Wiener medizinische Wochenschrift (1946), 1983, May-15, Volume: 133, Issue:9

    Topics: Anticoagulants; Aspirin; Cerebrovascular Disorders; Digitalis Glycosides; Dipyridamole; Diuretics; Heart Failure; Heme; Humans; Mitral Valve Prolapse; Platelet Aggregation; Sulfinpyrazone; Vasodilator Agents

1983
Quantitative determination of gastrointestinal bleeding in rats.
    Journal of pharmacological methods, 1982, Volume: 8, Issue:4

    Topics: Animals; Aspirin; Feces; Gastrointestinal Hemorrhage; Heme; Male; Rats; Rats, Inbred Strains; Time Factors

1982
The autoxidation of alpha alpha cross-linked hemoglobin: a possible role in the oxidative stress to endothelium.
    Artificial cells, blood substitutes, and immobilization biotechnology, 1995, Volume: 23, Issue:3

    Topics: Animals; Aspirin; Cells, Cultured; Cross-Linking Reagents; Endothelium, Vascular; Heme; Heme Oxygenase (Decyclizing); Hemoglobins; Humans; Methemoglobin; Oxidation-Reduction; Oxidative Stress; Swine

1995
Differential susceptibilities of the prosthetic heme of hemoglobin-based red cell substitutes. Implications in the design of safer agents.
    Biochemical pharmacology, 1993, Dec-14, Volume: 46, Issue:12

    Topics: Aspirin; Biological Transport; Blood Substitutes; Cross-Linking Reagents; Drug Design; Erythrocytes; Heme; Hemoglobins; Humans; Hydrogen Peroxide; Oxidation-Reduction; Oxygen

1993
Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX.
    The Journal of biological chemistry, 1997, Apr-04, Volume: 272, Issue:14

    Topics: Animals; Aspirin; Cyclooxygenase Inhibitors; Heme; Hydrogen Peroxide; Indomethacin; Leukotrienes; Lipid Peroxides; Lipoxygenase Inhibitors; Male; Peroxidase; Photosensitizing Agents; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins G; Prostaglandins H; Protoporphyrins; Sheep; Spectrophotometry, Atomic

1997
Structural characterization of human hemoglobin crosslinked by bis(3,5-dibromosalicyl) fumarate using mass spectrometric techniques.
    Protein science : a publication of the Protein Society, 1997, Volume: 6, Issue:12

    Topics: Amino Acid Sequence; Aspirin; Chromatography, Gel; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Heme; Hemoglobins; Humans; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Molecular Weight; Peptide Mapping

1997
Hemoglobin A0 and alpha-crosslinked hemoglobin (alpha-DBBF) potentiate agonist-induced platelet aggregation through the platelet thromboxane receptor.
    Artificial cells, blood substitutes, and immobilization biotechnology, 1998, Volume: 26, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acid; Aspirin; Blood Platelets; Blood Substitutes; Collagen; Drug Synergism; Heme; Hemoglobin A; Humans; Membrane Proteins; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Second Messenger Systems; Thrombin

1998
Crystal structure of Lysbeta(1)82-Lysbeta(2)82 crosslinked hemoglobin: a possible allosteric intermediate.
    Journal of molecular biology, 2000, Mar-10, Volume: 296, Issue:5

    Topics: Allosteric Regulation; Amino Acid Sequence; Aspirin; Binding Sites; Cross-Linking Reagents; Crystallization; Crystallography, X-Ray; Dimerization; Heme; Hemoglobins; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Oxygen; Oxyhemoglobins; Protein Structure, Tertiary; Thermodynamics

2000
Interactions of hemoglobin with hydrogen peroxide alters thiol levels and course of endothelial cell death.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:4

    Topics: Animals; Annexin A5; Aorta; Apoptosis; Aspirin; Cattle; Cell Death; Cells, Cultured; Endothelium, Vascular; Glutathione; Heme; Hemoglobin A; Hemoglobins; Humans; Hydrogen Peroxide; Oxidants; Sulfhydryl Compounds

2000
Redox concerns in the use of acellular hemoglobin-based therapeutic oxygen carriers: the role of plasma components.
    Artificial cells, blood substitutes, and immobilization biotechnology, 2000, Volume: 28, Issue:6

    Topics: Adult; Animals; Ascorbic Acid; Aspirin; Bicarbonates; Blood Substitutes; Body Fluids; Buffers; Free Radicals; Glutathione; Heme; Hemoglobin A; Hemoglobins; HEPES; Humans; Hydrogen-Ion Concentration; Iron; Methemoglobin; NAD; Oligochaeta; Oxidation-Reduction; Oxygen; Oxyhemoglobins; Phosphates; Reducing Agents; Tromethamine

2000
Binding modes of aromatic ligands to mammalian heme peroxidases with associated functional implications: crystal structures of lactoperoxidase complexes with acetylsalicylic acid, salicylhydroxamic acid, and benzylhydroxamic acid.
    The Journal of biological chemistry, 2009, Jul-24, Volume: 284, Issue:30

    Topics: Animals; Aspirin; Binding Sites; Cattle; Crystallography, X-Ray; Heme; Hydrogen Bonding; Hydroxamic Acids; Lactoperoxidase; Models, Molecular; Protein Binding; Protein Conformation; Salicylamides

2009
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.
    The Journal of biological chemistry, 2013, Oct-04, Volume: 288, Issue:40

    Topics: Acetylation; Amino Acid Sequence; Amino Acid Substitution; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Celecoxib; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Flurbiprofen; Guanidine; Heme; Humans; Indomethacin; Kinetics; Models, Biological; Mutant Proteins; Mutation; Naproxen; Oxygen; Palmitic Acid; Peroxidase; Protein Multimerization; Pyrazoles; Substrate Specificity; Sulfonamides

2013