heme has been researched along with aminolevulinic acid in 436 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 187 (42.89) | 18.7374 |
| 1990's | 81 (18.58) | 18.2507 |
| 2000's | 63 (14.45) | 29.6817 |
| 2010's | 62 (14.22) | 24.3611 |
| 2020's | 43 (9.86) | 2.80 |
| Authors | Studies |
|---|---|
| Badawy, AA | 1 |
| Bennett, M; Frykholm, BC; Lamon, JM; Tschudy, DP | 1 |
| Goldberg, A; McColl, KE; Moore, MR; Thompson, GT | 1 |
| Hederstedt, L; Holmgren, E; Rutberg, L | 1 |
| Brodie, MJ; Goldberg, A; Graham, DJ; McColl, KE; Moore, MR | 1 |
| Kappas, A; Sassa, S; Whetsell, WO | 2 |
| Omaye, ST; Turnbull, JD | 2 |
| Guzelian, PS; Swisher, RW | 1 |
| Boynton, JE; Gillham, NW; Wang, W | 1 |
| Woods, JS | 1 |
| Labbe-Bois, R; Volland, C | 1 |
| Ishida, A | 1 |
| Cohén, R; González-Cadavid, NF; Sáez de Córdova, C | 1 |
| Keyhani, E; Keyhani, J | 2 |
| Benoff, S; Bruce, SA; Skoultchi, AI | 1 |
| Djaldetti, M; Halbrecht, I; Malik, Z | 1 |
| Gidari, AS; Levere, RD | 1 |
| Becker, DM; Kramer, S | 1 |
| Kisser, W | 1 |
| Doss, M | 1 |
| Astin, AM; Haslam, JM | 3 |
| Chisolm, JJ | 1 |
| Granick, JL; Kappas, A; Sassa, S | 1 |
| Beale, SI; Granick, S | 1 |
| Druschky, KF; Schaller, KH; Schwanitz, G | 1 |
| Wang, WY | 1 |
| Charles, HP; McConville, ML | 2 |
| Meredith, PA; Moore, MR | 1 |
| de Matteis, F; Gibbs, AH; Sinclair, JF; Sinclair, P | 1 |
| Armas Merino, R; Canals, C; Gómez, R; Monsalve, V; Wolff, C | 1 |
| Brodie, MJ; Goldberg, A; Hardie, RA; Hunter, JA; McColl, KE; Moore, MR; Thompson, GG | 1 |
| Kondo, T; Kuchiba, K; Shimizu, Y | 1 |
| Bessler, H; Djaldetti, M; Malik, Z | 1 |
| Biliński, T; Lukaszkiewicz, J | 1 |
| Bacheschi, LA; de Assis, JL; Do Serro-Azul, LG; Marchiori, PE; Moraes, EC; Scaff, M; Yassuda, N | 1 |
| Bissell, DM; Liem, HH; Muller-Eberhard, U | 1 |
| Lithner, F | 1 |
| Bickers, D; Kappas, A; Sassa, S; Whetsell, WO | 1 |
| Freedman, ML; Ibrahim, NG; Spieler, PJ | 1 |
| Bruaux, P; Buchet, JP; Claeys-Thoreau, F; Lafontaine, A; Lauwerys, R; Roels, HA; van Overschelde, J; Verduyn, G | 1 |
| Jones, OT; Lodola, A | 1 |
| Robinson, SH; Yannoni, CZ | 1 |
| de Matteis, F; Unseld, A | 1 |
| Zarkowsky, HS | 1 |
| Sinnott, JL | 1 |
| Berek, I; Durkó, I; Ivánovics, G; Kiss, I; Miczák, A | 1 |
| Fuhr, JE; Leisy, M; Overton, M | 1 |
| Chang, CS; Chang, KP; Sassa, S | 1 |
| Dawber, NH; Thaler, MM | 1 |
| Bickers, DR; Harber, LC; Kappas, A; Keogh, L; Rifkind, AB | 1 |
| De Matteis, F; Gibbs, AH | 1 |
| Chanarin, I; Halliday, D; Samson, D | 1 |
| Neethling, AC; Percy, VA; Shanley, BC | 1 |
| Bhat, KS; Padmanaban, G; Sardana, MK | 1 |
| Minakami, S; Nakamura, M; Yasukochi, Y | 2 |
| Alvares, AP; Anderson, KE; Fischbein, A; Kappas, A; Kestenbaum, D; Sassa, S | 1 |
| Bissell, DM; Guzelian, PS | 1 |
| Buchet, JP; Hubermont, G; Lauwerys, R; Roels, H | 1 |
| Bossenmaier, I; Cardinal, R; Peterson, A; Watson, CJ | 1 |
| Chanarin, I; Halliday, D; Nicholson, DC; Samson, D | 2 |
| Ross, J; Sautner, D | 1 |
| Bissell, DM; Hammaker, LE | 1 |
| Ketterer, B; Singh Srai, K; Tipping, E | 1 |
| Rüdiger, W | 1 |
| Kappas, A; Maines, MD | 2 |
| Burk, RF; Correia, MA | 1 |
| Labbe, P; Labbe-Bois, R; Volland, C | 1 |
| Carstens, M; Neethling, AC; Percy, VA; Shanley, BC | 1 |
| Bossenmaier, I; Cardinal, R; Dhar, GJ; Petryka, ZJ; Watson, CJ | 1 |
| Griffiths, WT | 1 |
| Barrett, MB; Chisolm, JJ; Harrison, HV | 1 |
| Frederickson, EL; Mees, DE | 1 |
| Badawy, AA; Evans, M | 1 |
| Royer, M | 1 |
| Granick, S; Grieninger, G; Sassa, S; Sinclair, P | 1 |
| Akhtar, M; Zaman, Z | 1 |
| Gilchrist, MJ; Konisky, J | 1 |
| Burke, KA; Lascelles, J | 1 |
| Christodoulides, L; Ketterer, B; Srai, KS | 1 |
| Chmielnicka, J; Grabowska, U; Zareba, G | 1 |
| Delling, J; Elliott, T; Xu, K | 1 |
| Donohue, TJ; Schilke, BA | 1 |
| Padmanaban, G; Surolia, N | 1 |
| Gallagher, J; Kaderbhai, MA; Kaderbhai, N | 1 |
| Chmielnicka, J; Zareba, G | 1 |
| Kennedy, JC; Pottier, RH | 1 |
| Cornelius, CE; Freedland, RA; Rodgers, PA | 1 |
| Jahn, D; Söll, D; Verkamp, E | 1 |
| el-Sharabasy, MM; el-Waseef, AM; Hafez, MM; Salim, SA | 1 |
| Alessio, L; Buizza, P; De Panfilis, G; De Vincentiis, A; Ferioli, A; Leali, C; Pasolini, G | 1 |
| Casey, WM; Keesler, GA; Parks, LW | 1 |
| Andrzejczak, R; Antonowicz, J; Kuliczkowski, K; Smolik, R | 1 |
| Frustaci, JM; O'Brian, MR; Sangwan, I | 1 |
| Cox, TM; Gardner, LC; Smith, SJ | 1 |
| Bloomer, JR; Freese, D; Glock, M; Pascual-Leone, A; Payne, W; Rank, JM; Sharp, H | 1 |
| Ferramola de Sancovich, AM; Kleiman de Pisarev, DL; Sancovich, HA | 1 |
| Drummond, GS; Greenbaum, NL; Kappas, A | 1 |
| Goldberg, A; Herrick, AL; McColl, KE; Moore, MR; Wallace, AM | 1 |
| O'Neill, GP; Söll, D | 1 |
| Carter, BE; Moses, LC; Roth, KS; Spencer, PD | 1 |
| Grasso, JA; Liem, HH; Muller-Eberhard, U; Vincent, SH | 1 |
| Cutler, MG; Mair, J; Moore, MR | 1 |
| Atsmon, A; Bomstein, Y; Mamet, R; Mevasser, R; Schoenfeld, N | 1 |
| Aldonatti, C; San Martín de Viale, LC; Vila, MC | 1 |
| Hradilek, A; Neuwirt, J | 1 |
| Haines, KM; Nicolaides, NC; Stoeckert, CJ | 1 |
| Cutler, MG; Doyle, P; Moore, MR | 1 |
| Elliott, T; Roth, JR | 1 |
| Graham, AM; McColl, KE; Moore, MR | 1 |
| Bandlow, W; Magdolen, V; Oechsner, U; Schmalix, W | 1 |
| Fiechter, A; Meussdoerffer, F | 1 |
| Arnljots, K; Olsson, I | 1 |
| Anthony, C; Hill, S; Smith, A | 1 |
| Brodie, MJ; Macphee, GJ; McGuire, GM; Moore, MR; Park, BK; Thompson, GG | 1 |
| Lorenz, RT; Parks, LW | 1 |
| Goldberg, A; Moore, MR; Yeung Laiwah, AC | 1 |
| Durst, F; Jones, OT; Werck-Reichhart, D | 1 |
| Bissell, DM | 1 |
| Cox, TM; Gardner, LC | 1 |
| Bonkovsky, HL; Healey, JF; Robinson, JM; Shedlofsky, SI; Sinclair, PR; Swim, AT | 1 |
| Goldberg, A; Moore, MR; Yeung-Laiwah, AA | 1 |
| Hayashi, M; Honma, Y; Hozumi, M; Okabe-Kado, J | 1 |
| Laskey, JD; Ponka, P; Schulman, HM | 1 |
| Drummond, GS; Kappas, A; Landaw, SA; Sassa, S | 1 |
| Daldrup, T; Goerz, G; Gorys-Könemann, C; Teschke, R | 1 |
| Arrol, S; Cutler, MG | 1 |
| Chmielnicka, J; Kustra, G; Zareba, G | 1 |
| Graber, SG; Woodworth, RC | 1 |
| Lewis, TA; Parks, LW; Taylor, FR | 1 |
| Leeper, FJ | 1 |
| Angluster, J; Batlle, AM; de Souza, W; Salzman, TA | 1 |
| Guthrie, R; Ho, J; Tieckelmann, H | 1 |
| Balk, JL; Christenson, WR; Kohashi, M; Piper, WN; Sadler, EM; Tse, J | 1 |
| Beale, SI; Weinstein, JD | 1 |
| Dalwani, R; Datta, K; Dave, JM | 1 |
| Bonkovsky, HL; Healey, JF; Sinclair, JF; Sinclair, PR | 1 |
| Farrell, GC; Zaluzny, L | 1 |
| Bernstein, M; Shivji, A | 1 |
| Ponka, P; Schulman, HM | 1 |
| Doss, M; Sixel-Dietrich, F; Verspohl, F | 1 |
| Omura, T; Sadano, H | 1 |
| Oi, G; Wada, O | 1 |
| Meyer, UA; Schmid, R | 1 |
| Higashi, T; Kawamata, F; Sakamoto, T | 1 |
| Ali, MA; Brain, MC | 1 |
| Levin, EY | 1 |
| Berk, PD; Bossenmaier, I; Cardinal, RA; Sarkar, D; Schwartz, S; Stephenson, BD; Swaim, WR; Weimer, M | 1 |
| Goldenberg, GJ; Israels, LG; Schacter, BA; Yoda, B | 1 |
| Halvorsen, S | 1 |
| Bradlow, HL; Granick, S; Kappas, A; Sassa, S | 1 |
| Jordan, I; Kaplan, J; Kushner, JP; Ward, JH | 1 |
| Lamon, JM; Silbergeld, EK | 1 |
| Bonkowsky, HL; Elder, GH; Healey, JF; Shedlofsky, SI; Sinclair, JF; Sinclair, PR | 1 |
| Edwards, AM; Glistak, ML; Lucas, CM; Wilson, PA | 1 |
| Goldberg, A; McColl, KE | 1 |
| Friedland, ML; Ibraham, NG; Levere, RD | 1 |
| Lerner, R; Lindahl, J; Werner, B | 1 |
| Drummond, GS; Kappas, A | 1 |
| Clawson, GA; Moody, DE; Piper, WN; Smuckler, EA | 1 |
| Corona, D; López-Karpovitch, X; Marín, A; Molina Recio, NY; Piedras, J; Sánchez-Anzaldo, J | 1 |
| Evarts, RP; Marsden, E; Thorgeirsson, SS | 1 |
| Bonkowsky, HL; Schady, W | 1 |
| Chang, KJ; Lee, TP; Lu, FJ; Tung, TC | 1 |
| Bissell, DM; Hartmann, F | 1 |
| Burnham, BF; Kushner, JP; Morton, KA; Straka, JG | 1 |
| Goldberg, A; Laiwah, AC; Moore, MR | 1 |
| Percy, VA; Shanley, BC | 1 |
| Anderson, KE; Drummond, GS; Freddara, U; Sardana, MK; Sassa, S | 1 |
| Ibrahim, NG; Levere, RD; Lutton, JD | 1 |
| Althaus, FR; Giger, U; Hirsiger, H; Meier, PJ; Meyer, UA | 1 |
| Burnham, BF; Horton, WJ; Kushner, JP; Morton, KA | 1 |
| Bickers, DR | 1 |
| Hendry, GA; Jones, OT | 1 |
| Ammerer, G; Hartter, E; Richter, K; Ruis, H | 1 |
| Romeo, G | 1 |
| Janzer, JJ; Sanderson, KE; Stan-Lotter, H | 1 |
| Kappas, A; Sassa, S | 1 |
| Haddock, BA; Ingledew, WJ; Reid, GA | 1 |
| Waldenström, J | 1 |
| Goldberg, A; McColl, KE; Moore, MR; Thompson, GG; Wallace, AM | 1 |
| Fischer, VW; Hjelle, JJ; Poklis, A | 1 |
| Davies, DM; Johnson, EF; Liem, HH; Muller-Eberhard, U | 1 |
| Ingall, G; Rios, G; Sedman, R; Tephly, TR | 1 |
| De Matteis, F; Ray, DE | 1 |
| Kennedy, JC; Riopelle, RJ | 1 |
| Barnes, K; de Souza, P; Jacobs, A; Kaaba, S; May, A | 1 |
| Adam, C; Defresne, C; Guilmot-Bruneau, M; Hassoun, A; Saussez-De Temmerman, A; Wery-Follet, B | 1 |
| Piper, WN; Tofilon, PJ | 1 |
| Fukui, S; Isobe, N; Kamihara, T; Nakamura, I; Nakamura, N | 1 |
| Bissell, DM; Grandchamp, B; Licko, V; Schmid, R | 1 |
| Novogrodsky, A; Rubin, AL; Stenzel, KH | 1 |
| Brown, SB; Holroyd, JA; Offner, GD; Troxler, RF | 1 |
| Bonkowsky, HL; Healey, JF; Sinclair, JF; Sinclair, PR | 1 |
| Ord, JM; Wildenthal, K | 1 |
| Bonkowsky, HL; Erny, R; Healey, JF; Mayer, YP; Sinclair, PR | 1 |
| De Matteis, F; Smith, AG | 1 |
| Stobiecka, L | 1 |
| Rivera, M; Walker, FA | 1 |
| Chmielnicka, J; Lewandowska-Zyndul, E; Nasiadek, M | 1 |
| Fujii, J; Niikawa, N; Seo, HG; Soejima, H; Taniguchi, N | 1 |
| Conner, EA; Fowler, BA; Yamauchi, H | 1 |
| Behar, S; He, D; Lim, HW; Nomura, N; Sassa, S | 1 |
| Urata, G | 1 |
| Hayashi, N | 1 |
| Harada, K; Kim, Y; Ohmori, S; Tomokuni, K | 1 |
| Batlle, AM; Juknat, AA; Kotler, ML | 1 |
| Sakai, T | 1 |
| Hryhorenko, E; Morgan, J; Oseroff, AR; Paszkiewicz, G; Rittenhouse-Diakun, K; Van Leengoed, H; Whitaker, JE | 1 |
| Dailey, HA; Woodard, SI | 2 |
| Elleder, D; Kery, V; Kraus, JP | 1 |
| Gorman, N; Jacobs, JM; Jacobs, NJ; Sinclair, JF; Sinclair, PR; Walton, HS | 1 |
| Manganaro, F; Schipper, HM; Wang, X | 1 |
| Cecchini, G; Fuller, JH; Kim, J; McIntire, WS | 1 |
| Bedwell, J; Bown, SG; MacRobert, AJ; Ravi, B; Regula, J | 1 |
| Chan, RY; Kühn, LC; Ponka, P; Schulman, HM; Seiser, C | 1 |
| Behar, S; He, D; Lim, HW | 1 |
| Batlle, AM | 1 |
| Pilz, RB | 1 |
| Baumgartner, M; Bogdan, A; Callebert, J; Deybach, JC; Nordmann, Y; Puy, H; Touitou, Y; Voisin, P | 1 |
| Albakri, QA; Stuehr, DJ | 1 |
| Beaumont, C; Grandchamp, B; Hentze, MW; Picard, V; Porcher, C; Renaudie, F | 1 |
| Domachowske, JB; Malech, HL; Rafferty, SP | 1 |
| Bechara, EJ; DeLucia, R; Demasi, M; Penatti, CA | 1 |
| Madan Kumar, A; Söll, D | 1 |
| Kannangara, CG; von Wettstein, D; Vothknecht, UC | 1 |
| Hungerer, C; Jahn, D; Troup, B | 1 |
| Ponka, P | 1 |
| Battle, A; Fukuda, H; Riley, P; Washbrook, R | 1 |
| Bechara, EJ | 1 |
| Parks, LW; Smith, SJ | 1 |
| Behar, S; He, D; Lim, HW; Roberts, JE | 1 |
| Buzaleh, AM; del Carmen Batlle, AM; Nuñez, G; Vazquez, ES | 1 |
| Riley, PA; Washbrook, R | 1 |
| Berg, K; Giercksky, KE; Kongshaug, M; Moan, J; Nesland, JM; Peng, Q; Warloe, T | 1 |
| Padmaja, K; Prasad, AR; Ramamurthi, R | 1 |
| Best, EA; Cozart, P; Etter, JB; Lucast, LJ; Van Dehy, JA; Verderber, E | 1 |
| Ando, M; Hanioka, N; Jinno, H; Nishimura, T; Onodera, S | 1 |
| Inokuchi, H; Nakayashiki, T | 1 |
| Bechara, EJ; Carvalho, H; Demasi, M; Meneghini, R | 1 |
| Ferguson, SJ; Sinha, N | 1 |
| Bech, O; Berg, K; Moan, J; Peng, Q | 1 |
| Gorman, N; Jacobs, JM; Nichols, C; Sinclair, JF; Sinclair, PR; Walton, HS; Wood, SG | 1 |
| Brissette, J; Chen, N; Dotto, GP; Hasan, T; Maytin, E; Ortel, B | 1 |
| Araujo, LS; Del C Batlle, AM; Lombardo, ME | 1 |
| Muzyka, V; Schmidt, N; Veimer, S | 1 |
| Deybach, JC; Doss, MO; Frank, M; Gross, U; Jacob, K; Nordmann, Y; Sassa, S | 1 |
| O'Brian, MR; Sangwan, I | 1 |
| Fayadat, L; Franc, JL; Lanet, J; Niccoli-Sire, P | 1 |
| Enríquez de Salamanca, R; Fontanellas, A; Morán, MJ; Santos, JL | 1 |
| Braz, GR; Coelho, HS; Masuda, H; Oliveira, PL | 1 |
| Aguilar-González, MG; Albores, A; Hernández, A; López, ML; Mendoza-Figueroa, T | 1 |
| Hift, RJ | 1 |
| Bunce, RA; Qiu, F; Rivera, M; Stark, RE | 1 |
| CaJacob, CA; Loida, PJ; Thompson, RL; Walker, DM | 1 |
| Hamza, I; King, ND; O'Brian, MR; Qi, Z | 1 |
| Egger, NG; Flores, P; Fossum, TW; Jacques, SL; Motamedi, M; Rastegar, S; Vaidyanathan, VV; van Der Breggen, EW | 1 |
| Ebert, B; Handke, T; Moesta, KT; Rinneberg, H; Schlag, PM | 1 |
| de Rooij, FW; Edixhoven, A; Hinnen, P; Siersema, PD; Terlouw, EM; Tilanus, HW; van Dekken, H; van Hillegersberg, R; Wilson, JH | 1 |
| Aubert, C; Dolla, A; Durand, MC; Guerlesquin, F; Herbaud, ML; Thöny-Meyer, L | 1 |
| Matthews, EK; Mesenhöller, M | 1 |
| Buzaleh, AM; del Camen Martinez, M; del Carmen Batlle, AM | 1 |
| Piotrowski, JK; Szymańska, JA | 1 |
| Doss, MO; Gross, U; Kühnel, A | 1 |
| Gibson, SL; Havens, JJ; Hilf, R; Metz, L | 1 |
| Ryter, SW; Tyrrell, RM | 1 |
| Hoffmann, F; Lindberg, RL; Meyer, UA; Schuurmans, MM | 1 |
| Grimm, B; Papenbrock, J | 1 |
| Labbe, P; Lesuisse, E | 1 |
| Barros, MH; Nobrega, FG; Tzagoloff, A | 1 |
| Inokuchi, H; Kanjo, N; Nakahigashi, K; Oeda, K | 1 |
| Carter, RA; Hosie, AH; Johnston, AW; Klein, A; Poole, PS; Sawers, G; Yeoman, KH | 1 |
| Bogovski, S; Muzyka, V; Veidebaum, T; Viitak, A | 1 |
| Karbownik, M; Reiter, RJ | 1 |
| Funk, C; Vavilin, D; Vermaas, W; Xu, H | 1 |
| Deybach, JC; Doss, M; Doss, MO; Gross, U; Lamoril, J; Meissauer, U; Nordmann, Y; Puy, H | 1 |
| Balabanova, L; Fedinec, AL; Leffler, CW; Parfenova, H; Sullivan, CD; Wang, X | 1 |
| Araujo, LS; Batlle, A; Lombardo, ME | 1 |
| Back, K; Chon, SU; Chung, JS; Guh, JO; Ha, SB; Jang, SM; Jung, S; Kim, KM; Lee, HJ | 1 |
| Akhtar, MK; Hopper, DJ; Kaderbhai, MA; Kaderbhai, NN; Kelly, SL | 1 |
| Harper, P; Johansson, A; Möller, C | 1 |
| INOUE, S; KOIKE, S; SANO, S; SUMIYA, C; TANABE, Y | 1 |
| NEUBERGER, A | 1 |
| DANCEWICZ, AM | 1 |
| Beaumont, N; Deacon, A; Laftah, AH; Peters, TJ; Raja, KB; Simpson, RJ; Solanky, N; Srai, SK | 1 |
| Collaud, S; Juzeniene, A; Lange, N; Moan, J | 1 |
| Brien, JF; Bui, L; Jaronczyk, K; Marks, GS; McLaughlin, BE; Nakatsu, K; Soong, JM | 1 |
| Kain, KC; Smith, TG | 1 |
| Cadilla, CL; Collazo, E; De Jesús, W; Del Toro, A; León, RG; López-Garriga, J; Pietri, R; Ramos, C | 1 |
| Austin, CJ; Jamie, JF; Kosim-Satyaputra, P; Matin, A; Mizdrak, J; Parker, MW; Polekhina, G; Roberts, TH; Sirijovski, N; Truscott, RJ; Willows, RD | 1 |
| Laftah, AH; Latunde-Dada, GO; McKie, AT; Peters, TJ; Raja, KB; Simpson, RJ; Vergi, T | 1 |
| Apel, K; Goslings, D; Kim, C; Lee, KP; Meskauskiene, R; Nater, M | 1 |
| Correia, MA; Han, XM; Hefner, C; Lee, G; Maher, JJ | 1 |
| Herrick, AL; McColl, KE | 1 |
| Beale, SI; Srivastava, A | 1 |
| Moulin, M; Smith, AG | 1 |
| Beale, SI; Lake, V; Mayer, SM; Nogaj, LA; Srivastava, A; Willows, RD | 1 |
| Atteia, A; Beale, SI; van Lis, R | 1 |
| Batlle, A; Casas, A; Fukuda, H | 1 |
| Campo, MA; Lange, N | 1 |
| Perkins, WJ | 1 |
| Al-Waili, NS; Butler, GJ | 1 |
| Abraham, NG; Ahmad, M; Chow, JL; Gupte, SA; Mingone, CJ; Wolin, MS | 1 |
| Delepelaire, P; Létoffé, S; Wandersman, C | 2 |
| Harvie, SE | 1 |
| Astern, JM; Cherkasov, A; Goedken, M; Huang, M; Kameoka, Y; Leidal, KG; McCormick, S; Nauseef, WM; Suzuki, K | 1 |
| Ebert, B; Kemmner, W; Klamm, U; Macdonald, R; Moesta, KT; Rüttinger, S; Wan, K | 1 |
| Bloomer, JR; McGuire, BM | 1 |
| Chernova, T; Clothier, B; Davies, R; Edwards, RE; Gant, TW; Greaves, P; Luo, J; Robinson, SW; Smith, AG | 1 |
| Chang, KP; Dutta, S; Furuyama, K; Sassa, S | 1 |
| Cammack, R; Gareta, EG; Marritt, SJ; McKie, AT; Oakhill, JS | 1 |
| Heinemann, IU; Jahn, D; Jahn, M | 1 |
| Laftah, AH; Peters, TJ; Raja, KB; Simpson, RJ | 1 |
| Kauppinen, R; Pischik, E | 1 |
| Felitsyn, N; McLeod, C; Notterpek, L; Shroads, AL; Stacpoole, PW | 1 |
| Berkovitch, G; Doron, D; Malik, Z; Nudelman, A; Rephaeli, A | 1 |
| Ferreira, GC; Hunter, GA | 1 |
| Andersson, DE; Floderus, Y; Harper, P; Sardh, E | 1 |
| Harnois, T; Rogniaux, H; Rousselot, M; Zal, F | 1 |
| Flora, SJ; Gautam, P | 1 |
| Gerhard, GS; Zhang, S | 1 |
| Adams, MA; Benjamin, CD; Bourque, SL; Nakatsu, K | 1 |
| Biesalski, HK; Breusing, N; Flaccus, A; Grimm, S; Grune, T; Mvondo, D | 1 |
| Czarnecki, O; Grimm, B; Lorenzen, S; Peter, E; Pörs, Y; Richter, A | 1 |
| Hughes, D; Macvanin, M | 1 |
| Mikhael, M; Ponka, P; Sheftel, AD | 1 |
| Choiniere, JR; Gelb, MH; Scott, CR; Turecek, F | 1 |
| Brancaleoni, V; Cappellini, MD; Di Pierro, E; Graziadei, G; Tavazzi, D | 1 |
| Abe, F; Inoue, K; Ishizuka, M; Kohda, T; Komatsu, N; Nakajima, M; Ogura, S; Sano, Y; Takahashi, K; Tanaka, T | 1 |
| Bhatt, K; Dwivedi, N; Flora, SJ; Kushwah, PK; Pachauri, V | 1 |
| Bryson, D; Lawson, A; Lim, PL; Manjunath, S; Raner, GM | 1 |
| Fujita, H; Inoue, K; Inoue, M; Kobuchi, H; Munetomo, K; Ogino, T; Sasaki, J; Shuin, T; Utsumi, K; Utsumi, T; Yamamoto, M | 1 |
| Czarnecki, O; Grimm, B; Peter, E | 1 |
| Czarnecki, O; Grimm, B; Hedtke, B; Melzer, M; Pfannschmidt, T; Richter, A; Rothbart, M; Schröter, Y | 1 |
| Enríquez de Salamanca, R; Fontanellas, A; Harper, P; Mauleón, I; Prieto, J; Salido, E; Sampedro, A; Sardh, E; Unzu, C | 1 |
| Espinas, NA; Kobayashi, K; Masuda, T; Mochizuki, N; Takahashi, S | 1 |
| Berkovitch-Luria, G; Malik, Z; Nudelman, A; Rephaeli, A; Rozic, G; Weitman, M; Yakobovitch, S | 1 |
| Chen, X; Fu, C; Gao, C; Han, D; Ji, Z; Li, H; Li, X; Liu, H; Liu, Y; Liu, Z; Shi, H; Wang, C; Wang, L; Wu, J; Yang, G; Yin, F; Zhang, D; Zhao, S | 1 |
| Gong, K; Li, F; Liang, Q; Qi, Q; Wang, Q; Wang, Y | 1 |
| Lobanok, ES; Poleshko, AG; Volotovskii, ID | 1 |
| Ajioka, R; Cooksey, R; Cox, J; Gao, Y; Huang, J; Jones, D; Just, SF; King, D; Lee, SH; McClain, DA; Mitchell, TC; Simcox, JA | 1 |
| Beer, EN; Brennan, CM; Hunt, TM; Keane, ML; Leonard, JN; Mazzucca, NQ; Mezoian, T; Pellock, BJ; Perdue, S; Scola, SE | 1 |
| Bodmer, SI; Harms, FA; Mik, EG; Raat, NJ | 1 |
| Bissell, DM; Blanc, PD; Lai, JC; Meister, RK | 1 |
| Fujiwara, T; Fukuhara, N; Harigae, H; Ichinohasama, R; Ishizawa, K; Nakajima, M; Nakamura, Y; Niikuni, R; Okamoto, K; Okitsu, Y; Onishi, Y; Takahashi, K; Tanaka, T | 1 |
| Alhawaj, R; Kelly, MR; Patel, D; Sun, D; Wolin, MS | 1 |
| Chen, J; Du, G; Kang, Z; Zhang, J | 1 |
| Fukuhara, H; Hagiya, Y; Hayashi, M; Inoue, K; Nakajima, M; Ogura, S; Shuin, T; Tanaka, T | 1 |
| Hayashi, K; Kamiya, N; Kusakabe, T; Lee, JM; Tomozoe, Y | 1 |
| Baker, TA; Branco, DS; Hildick-Smith, GJ; Huston, NC; Kardon, JR; Paw, BH; Rhee, KY; Yien, YY | 1 |
| Nakanishi, T; Ogawa, T; Tamai, I; Yanagihara, C | 1 |
| Anderson, KE; Arvelakis, A; Balwani, M; Chen, B; Clavero, S; Desnick, RJ; Erwin, AL; Fiel, MI; Florman, SS; Gan, L; Gordon, RE; Kadirvel, S; Liu, LU; Martin, LD; Naik, H; Phillips, JD; Sadagoparamanujam, VM; Yasuda, M; Yu, C | 1 |
| Crowley, JR; Goldberg, DE; Henderson, JP; Sigala, PA | 1 |
| Hayashi, M; Ito, K; Miura, M; Nakajima, M; Ogura, S; Tanaka, T | 1 |
| Alam, M; Hooda, J; Zhang, L | 1 |
| Chen, B; Kraus, D; Palasuberniam, P; Yang, X | 1 |
| Cohen, R; Morohaku, K; Mukai, C; Pillai, VV; Selvaraj, V; Sirivelu, MP; Tu, LN; Zhao, AH | 1 |
| Chen, J; Ding, W; Du, G; Kang, Z; Zhang, J | 1 |
| Fujino, M; Ito, H; Li, XK; Nishio, Y; Tanaka, T | 1 |
| Batlle, A; Buzaleh, AM; Gerez, E; Lavandera, J; Martínez, Mdel C; Meiss, R; Rodríguez, J; Ruspini, S; Zuccoli, JR | 1 |
| Chapman, MS; Davis, SC; de Souza, AL; Gunn, J; Hasan, T; Kanick, SC; Marra, K; Maytin, EV; Pogue, BW; Samkoe, KS | 1 |
| Cheng, X; Jin, H; Qi, Q; Wang, Q; Yu, X | 1 |
| Dailey, HA; Dailey, TA; Gerdes, S; Jahn, D; Jahn, M; O'Brian, MR; Warren, MJ | 1 |
| Ashino, T; Kobayashi, Y; Yoshida, T | 1 |
| Arenas, FA; Cornejo, FA; Luraschi, R; Morales, EH; Mori, H; Muñoz-Villagrán, CM; Myers, CL; Nelson, J; Pinto, CA; Piotrowski, JS; Simpkins, SW; Vásquez, CC | 1 |
| Oliinyk, OS; Shemetov, AA; Verkhusha, VV | 1 |
| Adachi, Y; Izawa, S; Kawazoe, A; Kitajima, S; Ohkawa, Y; Sagami, I; Sato, T; Taketani, S; Umeda, M | 1 |
| Chen, D; Ge, M; Qian, X; Zhu, L | 1 |
| Baker, TA; Brown, BL; Kardon, JR; Sauer, RT | 1 |
| Hasuike, Y; Kuragano, T; Nagasawa, Y; Nakanishi, T; Nanami, M | 1 |
| Hirono, I; Kondo, H; Pedrosa-Gerasmio, IR; Sumi, A; Tanaka, T | 1 |
| Geng, Y; Guo, F; Li, X; Wan, S; Wang, Q; Yan, J; Yang, F; Yang, S; Zhang, J; Zhao, L | 1 |
| Daher, R; Gouya, L; Karim, Z; Lefebvre, T; Mirmiran, A; Nicolas, G; Peoc'h, K; Puy, H; Schmitt, C | 1 |
| Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H | 1 |
| Banse, C; Grimm, B; Richter, AS | 1 |
| Dan, S; Ishii, T; Ishizuka, M; Kitajima, Y; Kohda, T; Nakajima, M; Nishimura, Y; Tanaka, T; Yamazaki, K | 1 |
| Fushimi, T; Ichimoto, K; Ishii, T; Kishita, Y; Matsunaga, A; Murayama, K; Nakajima, M; Nozawa, N; Ogawa-Tominaga, M; Ohtake, A; Okazaki, Y; Shimura, M; Tajika, M; Takahashi, K; Tanaka, T; Tsuruoka, T | 1 |
| Gleadle, JM; MacGregor, MN; McNicholas, K | 1 |
| Liu, L; Pace, BS; Ward, CM; Yu, A; Zhu, X | 1 |
| Chan, KM; Gleadle, J; MacGregor, M; Vasilev, K | 1 |
| Comentale, G; Manzo, R; Pilato, E | 1 |
| Chen, N; Li, Y; Li, Z; Lu, N; Xu, Q; Zhang, C; Zhu, F | 1 |
| Layer, G | 1 |
| Čunderlíková, B; Jerigová, M; Kalafutová, A; Teplický, T | 1 |
| Hosogaya, N; Kawakami, A; Koga, T; Sato, S; Shimizu, T; Sumiyoshi, R; Tashiro, S; Yamamoto, H | 1 |
| Imi, Y; Shibata, K | 1 |
| Feng, C; Pan, M; Tang, L | 1 |
| Chatziantonio, C; Negoro, H; Razzaque, MS | 1 |
| Brown, BL; Taylor, JL | 1 |
| Borkovec, M; Erhart, F; Hosmann, A; Kiesel, B; Lang, A; Makolli, J; Mischkulnig, M; Roetzer, T; Rössler, K; Sperl, V; Traxler, D; Wadiura, LI; Widhalm, G | 1 |
| Córdoba, KM; Fontanellas, A; Jericó, D; Parra-Guillen, ZP; Trocóniz, IF; Vera-Yunca, D | 1 |
| Go, Y; Hara, I; Harada, A; Ishishita, S; Iwasaki, S; Kaneko, Y; Kinoshita, K; Kitahara, S; Matsuda, Y; Ohkawa, Y; Ohmori, Y; Shigenobu, S; Suzuki, T; Takahashi, M; Tatsumoto, S; Yamaguchi, K | 1 |
| Cysewski, D; Fabisiewicz, A; Mossakowska, BJ; Shahmoradi Ghahe, S; Siedlecki, JA; Tudek, B | 1 |
| Cheng, H; Liu, J; Nie, W; Shi, J; Yang, X; Zhang, K; Zhang, Y; Zhao, X; Zhou, T | 1 |
| Lange, N; Sansaloni-Pastor, S; Varesio, E | 1 |
| Harada, Y; Murayama, Y; Otsuji, E; Takamatsu, T; Tanaka, H | 1 |
| Dawuda, MM; Li, J; Liao, W; Lyu, J; Meng, X; Tang, Z; Wang, J; Wu, Y; Xie, J; Yu, J; Yuan, H | 1 |
| Chen, B; Howley, R; Mansi, M; Restrepo, J; Shinde, J | 1 |
| Chan, KM; MacGregor, M; Vasilev, K | 1 |
| Kiening, M; Lange, N | 1 |
| Che, Q; Li, C; Lu, H; Wang, Q; Zeng, K | 1 |
| Igase, M; Iwatani, N; Mizukami, Y; Mizuno, T; Sakai, A; Watanabe, K | 1 |
| Dailey, HA; Medlock, AE | 1 |
| Fujii, T; Fujimoto, K; Hori, S; Iida, K; Miyake, M; Morizawa, Y; Nakai, Y; Oda, Y; Onishi, K; Onishi, S; Owari, T; Tanaka, N; Tatsumi, Y | 1 |
| Chen, T; Cui, Z; He, G; Jiang, M; Sun, X; Wang, Z | 1 |
| Bagnato, VS; da Silva, GR; Dos Santos, AL; Dos Santos, MC; Dos Santos, SC; Inada, NM; Rodrigues de Lima, V; Sanches, EA; Soares, AC; Ţălu, Ş | 1 |
| Fukushima, A; Fumoto, Y; Furihata, T; Hagiwara, H; Handa, H; Hata, S; Kakutani, N; Kang, D; Kinugawa, S; Maekawa, S; Masunaga, T; Nambu, H; Sabe, H; Setoyama, D; Takada, S; Ueda, K; Yokota, T | 1 |
| Barinka, C; Havlinova, B; Kasparek, P; Korandova, Z; Kutil, Z; Milosevic, M; Novakova, Z; Ondrakova, M; Rohlena, J; Sandoval-Acuña, C; Truksa, J; Vrbacky, M | 1 |
| Abe, K; Furusawa, S; Ide, T; Ikeda, M; Imai, H; Ishimaru, K; Koumura, T; Matsushima, S; Miyake, R; Miyamoto, HD; Tadokoro, T; Tsutsui, H; Tsutsui, Y; Watanabe, M; Yamada, KI | 1 |
| Gawecki, R; Mrozek-Wilczkiewicz, A; Polanski, J | 1 |
| Córdoba, KM; Ena, J; Enríquez de Salamanca, R; Fontanellas, A; Jericó, D; Morales-Conejo, M; Solares, I | 1 |
| Balwani, M; Bonkovsky, HL; Lim, JK; Wang, B | 1 |
| Berger, W; Bian, S; Dyczynski, M; Efferth, T; Elling, U; Gabler, L; Gojo, J; Hagelkruys, A; Hoepfner, D; Horn, M; Knoblich, JA; Krauditsch, C; Laemmerer, A; Lötsch, D; Orthofer, M; Penninger, JM; Peyrl, A; Rózsová, M; Spiegl-Kreinecker, S; Studer, C; Taubenschmid-Stowers, J; Widhalm, G | 1 |
| Adjei, MO; Du, J; Li, S; Li, X; Luan, A; Luo, J; Ma, J | 1 |
| Balwani, M; Keel, S; Yasuda, M | 1 |
| Fujita, T; Negoro, R; Watanabe, K | 1 |
| Ahmad, P; Alyemeni, MN; Ashraf, M; Kaya, C; Rinklebe, J | 1 |
| Fan, T; Grimm, B; Hedtke, B; Roling, L | 1 |
| Chen, S; Chen, X; Guo, M; Liu, H; Su, H | 1 |
| Fukuda, Y; Grace, CR; Kavdia, K; Li, Y; Lynch, J; Peng, J; Ranjit, S; Robinson, CG; Schuetz, JD; Wang, Y; Xia, Y | 1 |
| Abudukeyoumu, A; Hou, DY; Lai, ZZ; Li, MQ; Lu, JJ; Tao, X; Wu, JN; Xie, F; Zhang, X; Zhu, XY | 1 |
| Lange, N; Sansaloni-Pastor, S | 1 |
| Chen, B; Myers, KA; Palasuberniam, P; Wang, C; Yang, X | 1 |
| Cui, Z; Gong, K; Jiang, X; Jiang, Z; Liang, Q; Qi, Q; Wang, Q; Zhang, J; Zheng, H | 1 |
66 review(s) available for heme and aminolevulinic acid
| Article | Year |
|---|---|
The functions and regulation of tryptophan pyrrolase.
Topics: Allosteric Regulation; Aminolevulinic Acid; Animals; Dactinomycin; Feedback; Gluconeogenesis; Heme; Kinetics; Kynurenine; Liver; NAD; NADP; Rats; Tryptophan; Tryptophan Oxygenase | 1977 |
Enzymatic formation and cellular regulation of heme synthesis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Coenzyme A; Coproporphyrinogens; Enzyme Induction; Heme; Humans; Liver; Porphobilinogen; Porphobilinogen Synthase; Porphyrias; Protoporphyrins; Uroporphyrinogens | 1977 |
The neurological manifestations of porphyria: a review.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Heme; Humans; Liver; Liver Diseases; Nervous System; Neurologic Manifestations; Peripheral Nerves; Porphobilinogen; Porphyrias; Porphyrins | 1977 |
[Biochemical methods for the detection of lead poisoning (author's transl)].
Topics: Aminolevulinic Acid; Coproporphyrins; Economics; Erythrocytes; Heme; Humans; Lead; Lead Poisoning; Methods; Occupational Diseases; Porphobilinogen Synthase; Protoporphyrins; Suicide | 1977 |
[Pathobiochemistry of porphyrias].
Topics: Acute Disease; Aminolevulinic Acid; Catalase; Chronic Disease; Cytochrome P-450 Enzyme System; Heme; Humans; Liver; Liver Diseases; Porphobilinogen; Porphyrias; Porphyrins; Protoporphyrins | 1977 |
Heme metabolites in blood and urine in relation to lead toxicity and their determination.
Topics: Aminolevulinic Acid; Coproporphyrins; Dose-Response Relationship, Drug; Erythrocytes; Heme; Hemoglobins; Humans; Lead Poisoning; Mass Screening; Monitoring, Physiologic; Protoporphyrins; Risk | 1978 |
Some biochemical and clinical aspects of lead intoxication.
Topics: Aging; Aminolevulinic Acid; Anemia; Autonomic Nervous System; Central Nervous System; Cytochrome P-450 Enzyme System; Cytoplasm; DNA; Drug Interactions; Ethanol; Heme; Humans; Kidney; Lead Poisoning; Mitochondria; Nutrition Disorders; Pharmaceutical Preparations; Protoporphyrins; RNA | 1978 |
Hemes, chlorophylls, and related compounds: biosynthesis and metabolic regulation.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bacteria; Chlorophyll; Fungi; Heme; Hemin; Humans; Lead Poisoning; Liver; Methods; Oxygen; Plants; Porphyrias; Porphyrins; Protein Biosynthesis; Protoporphyrins; Uroporphyrinogens | 1978 |
[Chromosome studies in patients with intermittent porphyria].
Topics: Adult; Aminolevulinic Acid; Chromosome Aberrations; Female; Heme; Humans; Hydroxymethylbilane Synthase; Male; Middle Aged; Pedigree; Porphobilinogen; Porphyrias | 1979 |
Genetic control of chlorophyll biosynthesis in Chlamydomonas reinhardtii.
Topics: Aminolevulinic Acid; Chlamydomonas; Chlorophyll; Genetic Complementation Test; Heme; Light; Magnesium; Mitochondria; Mutation; Phenotype; Porphyrins | 1978 |
The lead problem in children: dictum and polemic.
Topics: Adolescent; Adult; Age Factors; Aminolevulinic Acid; Anemia; Animals; Child; Child, Preschool; Erythrocytes; Erythrocytes, Abnormal; Fanconi Syndrome; Female; Heme; Humans; Infant; Intellectual Disability; Lead; Lead Poisoning; Male; Porphobilinogen Synthase; Rats; Seasons | 1976 |
The laboratory investigation of the porphyrin disorders: a review.
Topics: Aminolevulinic Acid; Erythropoiesis; Feces; Heme; Humans; Lead Poisoning; Liver; Molecular Conformation; Porphyrias; Porphyrins; Protoporphyrins; Terminology as Topic | 1976 |
Endogenous protoporphyrin IX, a clinically useful photosensitizer for photodynamic therapy.
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Photochemotherapy; Prodrugs; Protoporphyrins | 1992 |
Glutamyl-transfer RNA: a precursor of heme and chlorophyll biosynthesis.
Topics: Aldehyde Oxidoreductases; Amino Acid Sequence; Amino Acyl-tRNA Synthetases; Aminolevulinic Acid; Animals; Bacteria; Chlorophyll; Heme; Intramolecular Transferases; Isomerases; Molecular Sequence Data; RNA, Transfer, Glu; Sequence Homology, Nucleic Acid | 1992 |
Transfer RNA and the formation of the heme and chlorophyll precursor, 5-aminolevulinic acid.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Base Sequence; Chlorophyll; Glutamate-tRNA Ligase; Heme; Molecular Sequence Data; Nucleic Acid Conformation; RNA, Transfer, Glu | 1990 |
Pathogenesis of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Heme; Humans; Nervous System; Porphobilinogen; Porphyrias | 1987 |
The biosynthesis of porphyrins, chlorophylls, and vitamin B12.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bile Pigments; Bilirubin; Biliverdine; Chlorophyll; Chlorophyllides; Cytochromes; Ferrochelatase; Heme; Hydroxymethylbilane Synthase; Metalloporphyrins; Metalloproteins; Nickel; Nucleotides; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Plants; Porphobilinogen Synthase; Porphyrins; Protoporphyrinogen Oxidase; Uroporphyrinogen Decarboxylase; Uroporphyrinogen III Synthetase; Vitamin B 12 | 1985 |
Recent progress in the studies of lead poisoning.
Topics: Air Pollution; Aminolevulinic Acid; Animals; Body Burden; Brain Diseases; Child; Environmental Exposure; Erythrocytes; Heme; Humans; Intellectual Disability; Kidney Diseases; Kidney Neoplasms; Lead; Lead Poisoning; Mice; Neuritis; Occupational Medicine; Porphobilinogen Synthase; Porphyrins; Vehicle Emissions; Water Pollution, Chemical | 1972 |
Intermittent acute porphyria: the enzymatic defect.
Topics: 5-Aminolevulinate Synthetase; Adenosine Triphosphatases; Alanine; Aminolevulinic Acid; Ammonia-Lyases; Dysautonomia, Familial; Heme; Humans; Liver; Porphobilinogen; Porphyrias; Porphyrins | 1974 |
Editorial: Inhibitors of erythropoiesis.
Topics: Aminolevulinic Acid; Anemia; Animals; Bone Marrow; Bone Marrow Cells; Depression, Chemical; Erythrocytes; Erythropoiesis; Erythropoietin; Estrogens; Feedback; Female; Heme; Hemoglobins; Humans; Hypoxia; Immunoglobulin G; In Vitro Techniques; Infant, Newborn; Iron; Male; Mice; Models, Biological; Nephritis; Polycythemia; Polycythemia Vera; Rats | 1974 |
Endocrine-gene interaction in the pathogenesis of acute intermittent porphyria.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Ammonia-Lyases; Androstenedione; Animals; Biotransformation; Carbon Radioisotopes; Chick Embryo; Heme; Humans; Liver; Molecular Biology; Oxidoreductases; Pedigree; Porphyrias; Porphyrins; Steroids; Testosterone | 1974 |
Heme metabolism in erythroid and hepatic cells.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrinogen Oxidase; Erythrocytes; Erythropoiesis; Ferrochelatase; Flavoproteins; Heme; Heme Oxygenase (Decyclizing); Humans; Liver; Liver Diseases; Mitochondrial Proteins; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Porphobilinogen; Porphobilinogen Synthase; Porphyrias; Protoporphyrinogen Oxidase; Skin Diseases; Uroporphyrinogen Decarboxylase; Uroporphyrinogen III Synthetase | 1983 |
Neurologic manifestations of acute porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Animals; Central Nervous System; Depression; Electrophysiology; gamma-Aminobutyric Acid; Glycine; Heme; Humans; Light; Liver Diseases; Muscle Hypotonia; Nerve Fibers; Nerve Fibers, Myelinated; Nervous System Diseases; Pain, Intractable; Peripheral Nerves; Porphobilinogen; Porphobilinogen Synthase; Porphyrias; Prognosis; Seizures; Vitamin B 6 Deficiency; Zinc | 1982 |
Haems and chlorophylls: comparison of function and formation.
Topics: Aminolevulinic Acid; Animals; Biological Evolution; Chlorophyll; Heme; Hemoglobins; Humans; Iron; Magnesium; Photosynthesis; Plant Physiological Phenomena; Porphyrins; Protoporphyrins; Structure-Activity Relationship | 1980 |
The hepatic porphyrias.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adolescent; Adult; Aminolevulinic Acid; Chemical Phenomena; Chemistry; Child; Child, Preschool; Female; Gene Expression Regulation; Heme; Humans; Infant; Liver; Liver Diseases; Male; Middle Aged; Photosensitivity Disorders; Porphobilinogen; Porphyria, Acute Intermittent; Porphyrias; Porphyrias, Hepatic; Porphyrins; Prenatal Diagnosis; Protoporphyria, Erythropoietic; Recurrence; Skin Diseases | 1980 |
Genetic, metabolic, and biochemical aspects of the porphyrias.
Topics: Aminolevulinic Acid; Animals; Cat Diseases; Cats; Cattle; Cattle Diseases; Erythrocytes; Heme; Humans; Liver; Porphobilinogen; Porphobilinogen Synthase; Porphyrias; Porphyrinogens; Porphyrins; Rodent Diseases; Sciuridae; Swine; Swine Diseases | 1981 |
The porphyrias--a review.
Topics: Acute Disease; Aged; Alcoholism; Aminolevulinic Acid; Feces; Female; Heme; Humans; Iron; Liver Diseases; Male; Porphobilinogen; Porphyrias; Skin Diseases; Time Factors | 1981 |
[The chemistry of porphyrins and their precursors on the heme biosynthetic chain].
Topics: Aminolevulinic Acid; Heme; Humans; Porphobilinogen; Porphyrins; Uroporphyrinogens | 1995 |
[Porphyrin biosynthetic pathway and its regulation].
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Erythrocytes; Heme; Liver; Porphyrins; Protoporphyrins | 1995 |
[Metabolic fate of porphyrin and its precursors in porphyria and porphyrinuria].
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Porphyrias; Porphyrins; Protoporphyrins | 1995 |
[Reviews on biochemical markers of lead exposure with special emphasis on heme and nucleotide metabolisms].
Topics: 5'-Nucleotidase; Aminolevulinic Acid; Biomarkers; Coproporphyrins; Environmental Exposure; Environmental Monitoring; Female; Heme; Humans; Lead Poisoning; Male; Maximum Allowable Concentration; Nucleotides; Porphobilinogen Synthase; Protoporphyrins; Pyrimidine Nucleotides | 1995 |
Porphyrins, porphyrias, cancer and photodynamic therapy--a model for carcinogenesis.
Topics: Aminolevulinic Acid; Heme; Humans; Models, Biological; Neoplasms; Photochemotherapy; Porphyrias; Porphyrins | 1993 |
Glutamate transfer RNA: a cofactor for heme and chlorophyll biosynthesis.
Topics: Aminolevulinic Acid; Base Sequence; Chlorophyll; Heme; Molecular Sequence Data; Plants; RNA, Transfer, Glu | 1996 |
[Unusual pathways and environmentally regulated genes of bacterial heme biosynthesis].
Topics: Aminolevulinic Acid; Animals; Archaea; Bacteria; Gene Expression Regulation, Bacterial; Heme; Hydroxymethylbilane Synthase; Mammals; Plants; Pyrroles; Saccharomyces cerevisiae; Tetrapyrroles; Uroporphyrinogens | 1996 |
Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells.
Topics: Aminolevulinic Acid; Animals; Cytoplasm; Erythrocytes; Heme; Iron; Liver; Mammals; Mitochondria; Models, Biological; Organ Specificity; Receptors, Transferrin; Transcription, Genetic | 1997 |
Oxidative stress in acute intermittent porphyria and lead poisoning may be triggered by 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Calcium; DNA Damage; Heme; Humans; Iron; Lead Poisoning; Lipid Peroxidation; Mitochondria; Oxidative Stress; Porphyria, Acute Intermittent; Porphyrias; Proteins; Rats; Reactive Oxygen Species | 1996 |
5-Aminolevulinic acid-based photodynamic therapy. Clinical research and future challenges.
Topics: Aminolevulinic Acid; Forecasting; Heme; Humans; Neoplasms; Photochemotherapy; Protoporphyrins; Research; Skin Diseases; Skin Neoplasms | 1997 |
[Use of 5-aminolevulinic acid in photochemotherapy and fluorescence diagnostics].
Topics: Aminolevulinic Acid; Fluorescence; Heme; Humans; Photochemotherapy; Protoporphyrins; Skin Diseases; Skin Neoplasms | 1998 |
Fluorescence as a concept in colorectal lymph node diagnosis.
Topics: Aminolevulinic Acid; Colorectal Neoplasms; Dihematoporphyrin Ether; Fluorescent Dyes; Heme; Humans; Intraoperative Care; Lymph Node Excision; Lymphatic Metastasis; Pilot Projects; Sentinel Lymph Node Biopsy; Spectrometry, Fluorescence | 2000 |
The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties.
Topics: Aminolevulinic Acid; Animals; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Humans; Lipid Peroxidation; Mammals; Models, Chemical; Oxidants; Oxidation-Reduction; Oxidative Stress; Porphyrins; Reactive Oxygen Species | 2000 |
Regulatory network of tetrapyrrole biosynthesis--studies of intracellular signalling involved in metabolic and developmental control of plastids.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Chlorophyll; Chloroplasts; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Light; Lyases; Magnoliopsida; Molecular Structure; Oxidation-Reduction; Phytochrome; Plants; Pyrroles; Signal Transduction; Tetrapyrroles | 2001 |
Melatonin protects against oxidative stress caused by delta-aminolevulinic acid: implications for cancer reduction.
Topics: Aminolevulinic Acid; Animals; Anticarcinogenic Agents; Heme; Humans; Melatonin; Models, Biological; Neoplasms; Oxidative Stress; Rats | 2002 |
On the selectivity of 5-aminolevulinic acid-induced protoporphyrin IX formation.
Topics: Aminolevulinic Acid; Animals; Hematoporphyrin Photoradiation; Heme; Humans; Molecular Structure; Neoplasms; Photosensitizing Agents; Protoporphyrins | 2004 |
Acute intermittent porphyria.
Topics: Abdominal Pain; Adult; Aminolevulinic Acid; Cytochrome P-450 Enzyme System; Erythrocytes; Female; Heme; Humans; Porphobilinogen; Porphyria, Acute Intermittent | 2005 |
Regulation of tetrapyrrole biosynthesis in higher plants.
Topics: Aminolevulinic Acid; Biliverdine; Chlorophyll; Heme; Light; Plant Physiological Phenomena; Plants; Signal Transduction; Tetrapyrroles | 2005 |
Use of ALA and ALA derivatives for optimizing ALA-based photodynamic therapy: a review of our experience.
Topics: Aminolevulinic Acid; Animals; Esterases; Heme; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Prodrugs; Protoporphyrins | 2006 |
Fluorescence diagnosis using enzyme-related metabolic abnormalities of neoplasia.
Topics: Aminolevulinic Acid; Animals; Diagnostic Imaging; Drug Delivery Systems; Fluorescence; Glycolysis; Heme; Humans; Neoplasms; Peptide Hydrolases; Photochemotherapy; Photosensitizing Agents; Porphyrins | 2006 |
Aminolevulinic acid and photodynamic combination therapy in the treatment of actinic keratoses: caring for the patient.
Topics: Aminolevulinic Acid; Heme; Humans; Keratosis; Nurse's Role; Nursing Assessment; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Protoporphyrins; Skin Care; Skin Neoplasms; Ultraviolet Rays | 2007 |
The biochemistry of heme biosynthesis.
Topics: Aminolevulinic Acid; Archaea; Bacteria; Heme; Herbicides; Models, Molecular; Neoplasms; Photochemotherapy; Plants; Porphyrias; RNA, Transfer; Tetrapyrroles | 2008 |
5-aminolevulinate synthase: catalysis of the first step of heme biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Anemia, Sideroblastic; Heme; Humans; Kinetics; Models, Molecular; Mutation; Structure-Activity Relationship | 2009 |
Porphyrias at a glance: diagnosis and treatment.
Topics: Acute Disease; Aminolevulinic Acid; Chronic Disease; Genetic Testing; Heme; Humans; Porphobilinogen; Porphyrias; Porphyrins | 2010 |
Aminolevulinic Acid-Based Tumor Detection and Therapy: Molecular Mechanisms and Strategies for Enhancement.
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2015 |
5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction.
Topics: Aminolevulinic Acid; Heme; Heme Oxygenase-1; Histocompatibility; Humans; Immunity; Immunologic Factors; Inflammation; Macrophages; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Signal Transduction; Transplantation, Homologous | 2016 |
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product.
Topics: Aminolevulinic Acid; Archaea; Bacteria; Coproporphyrinogen Oxidase; Coproporphyrins; Heme; Iron; Protoporphyrins; Tetrapyrroles; Uroporphyrinogen Decarboxylase | 2017 |
Chemical-induced coordinated and reciprocal changes in heme metabolism, cytochrome P450 synthesis and others in the liver of humans and rodents.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Liver; Organic Chemicals; Rodentia; Toxicology; Transcription Factors | 2016 |
Misdistribution of iron and oxidative stress in chronic kidney disease.
Topics: Aminolevulinic Acid; Anemia; Hematinics; Heme; Hepcidins; Humans; Inflammation; Iron; Iron Overload; Leptin; Mitochondria; Oxidative Stress; Renal Insufficiency, Chronic | 2019 |
Regulation and tissue-specific expression of δ-aminolevulinic acid synthases in non-syndromic sideroblastic anemias and porphyrias.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Anemia, Sideroblastic; Animals; Binding Sites; GATA1 Transcription Factor; Gene Expression Regulation; Heme; Humans; Liver; Mice; Mutation, Missense; Porphyrias; Promoter Regions, Genetic | 2019 |
In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?
Topics: Amino Acid Transport Systems; Aminolevulinic Acid; Brain Neoplasms; Coproporphyrinogens; Ferrochelatase; Fluorescence; Glucose; Heme; Humans; Iron; MicroRNAs; Mitochondria; Mutation; NADP; Neoplasms; Oncogenes; Optical Imaging; Peptide Transporter 1; Photochemotherapy; Protoporphyrins; Skin Neoplasms; Symporters; Tumor Hypoxia; Tumor Microenvironment; Urinary Bladder Neoplasms | 2019 |
Heme biosynthesis in prokaryotes.
Topics: Aerobiosis; Aminolevulinic Acid; Anaerobiosis; Archaea; Bacteria; Heme; Photosynthesis; Prokaryotic Cells; Tetrapyrroles | 2021 |
Structural basis for dysregulation of aminolevulinic acid synthase in human disease.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Anemia, Sideroblastic; Animals; Genetic Diseases, X-Linked; Heme; Humans; Structure-Activity Relationship | 2022 |
5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence Imaging for Tumor Detection: Recent Advances and Challenges.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Glioma; Heme; Humans; Optical Imaging; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Radiopharmaceuticals | 2022 |
A Recap of Heme Metabolism towards Understanding Protoporphyrin IX Selectivity in Cancer Cells.
Topics: Aminolevulinic Acid; Animals; Heme; Iron; Mammals; Neoplasms; Porphyrins; Protoporphyrins | 2022 |
A primer on heme biosynthesis.
Topics: Aminolevulinic Acid; Heme; Iron | 2022 |
Understanding Carbohydrate Metabolism and Insulin Resistance in Acute Intermittent Porphyria.
Topics: Aminolevulinic Acid; Animals; Carbohydrate Metabolism; Glucose; Heme; Humans; Hydroxymethylbilane Synthase; Insulin; Insulin Resistance; Mice; Porphobilinogen; Porphyria, Acute Intermittent | 2022 |
AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Topics: Abdominal Pain; Aminolevulinic Acid; Antiemetics; Carcinoma, Hepatocellular; Creatinine; Female; Heme; Hemin; Humans; Hypertension; Liver Neoplasms; Middle Aged; Porphobilinogen; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Porphyrias, Hepatic; Quality of Life; Renal Insufficiency, Chronic; United States | 2023 |
Applications of the Whole-Cell System in the Efficient Biosynthesis of Heme.
Topics: Aminolevulinic Acid; Biosynthetic Pathways; Heme; Metabolic Engineering; Synthetic Biology | 2023 |
3 trial(s) available for heme and aminolevulinic acid
| Article | Year |
|---|---|
Hematin therapy for the neurologic crisis of tyrosinemia.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Aminolevulinic Acid; Heme; Hemin; Heptanoates; Humans; Infant; Liver Transplantation; Male; Tyrosine | 1991 |
Plasma porphobilinogen as a sensitive biomarker to monitor the clinical and therapeutic course of acute intermittent porphyria attacks.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Arginine; Biomarkers; Chromatography, Ion Exchange; Drug Monitoring; Female; Glucose; Heme; Humans; Male; Porphobilinogen; Porphyria, Acute Intermittent; Sensitivity and Specificity | 2009 |
Single-arm, open-label pilot intervention study to investigate an effect of oral 5-aminolevulinic acid plus sodium ferrous citrate on glucocorticoid reduction in patients with adult-onset Still disease: Study protocol for clinical trial (SPIRIT compliant)
Topics: Administration, Oral; Adult; Aminolevulinic Acid; Citric Acid; Drug Therapy, Combination; Female; Ferrous Compounds; Glucocorticoids; Heme; Heme Oxygenase-1; Humans; Japan; Male; Photosensitizing Agents; Pilot Projects; Safety; Still's Disease, Adult-Onset; Trace Elements; Treatment Outcome | 2020 |
367 other study(ies) available for heme and aminolevulinic acid
| Article | Year |
|---|---|
Prevention of acute porphyric attacks by intravenous haematin.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Blood Pressure; Circadian Rhythm; Drug Evaluation; Female; Heme; Hemin; Humans; Infusions, Parenteral; Menstruation; Porphobilinogen; Porphyrias; Pulse; Remission, Spontaneous | 1978 |
Haematin therapy and leucocyte delta-aminolevulinic-acid-synthase activity in prolonged attack of acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Adult; Aminolevulinic Acid; Drug Administration Schedule; Female; Heme; Hemin; Humans; Infusions, Parenteral; Leukocytes; Peak Expiratory Flow Rate; Porphyrias; Respiration; Time Factors | 1979 |
Role of heme in synthesis and membrane binding of succinic dehydrogenase in Bacillus subtilis.
Topics: Aminolevulinic Acid; Bacillus subtilis; Bacterial Proteins; Cell Membrane; Heme; Membrane Proteins; Mutation; Peptide Biosynthesis; Protein Binding; Succinate Dehydrogenase | 1979 |
Quantitation of 3-ethyl-5-hydroxy-4,5-dimethyl-delta 3-pyrrolin-2-one in the urine of patients with acute intermittent porphyria.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Chromatography, Gas; Female; Heme; Humans; Porphobilinogen; Porphyrias; Pyrroles | 1979 |
Studies on porphyrin-heme biosynthesis in organotypic cultures of chick dorsal root ganglia. II. The effect of lead.
Topics: Aminolevulinic Acid; Animals; Chick Embryo; Edetic Acid; Ganglia, Spinal; Heme; Lead Poisoning; Organ Culture Techniques; Porphyrins | 1979 |
Degradation of cytochrome P-450 heme in ascorbic acid-deficient guinea pigs.
Topics: Aminolevulinic Acid; Animals; Ascorbic Acid Deficiency; Biotransformation; Body Weight; Carbon Dioxide; Cytochrome P-450 Enzyme System; Cytochromes; Diet; Guinea Pigs; Heme; Male; Organ Size | 1979 |
Degradation of cytochrome P-450 haem by carbon tetrachloride and 2-allyl-2-isopropylacetamide in rat liver in vivo and in vitro. Involvement of non-carbon monoxide-forming mechanisms.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Kidney; Lipid Metabolism; Liver; Male; Microsomes, Liver; Rats | 1979 |
Synthesis and sideedness of membrane-bound respiratory nitrate reductase (EC1.7.99.4) in Escherichia coli lacking cytochromes.
Topics: Aminolevulinic Acid; Apoproteins; Binding Sites; Cell Membrane; Chloramphenicol; Cytochromes; Cytoplasm; Escherichia coli; Galactosidases; Heme; Membranes; NAD; NADH, NADPH Oxidoreductases; Nitrate Reductases; Nitrates; Oxygen Consumption | 1975 |
Genetic control of chlorophyll biosynthesis in chlamydomonas: analysis of a mutant affecting synthesis of delta-aminolevulinic acid.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Chlamydomonas; Chlorophyll; Chloroplasts; Electron Transport Complex IV; Genes; Heme; Levulinic Acids; Mutation; Porphobilinogen Synthase; Protoporphyrins | 1975 |
Heme regulation of cytochrome oxidase synthesis in fetal rat liver.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cobalt; Cycloheximide; Electron Transport Complex IV; Female; Fetus; Heme; In Vitro Techniques; Leucine; Mitochondria, Liver; Pregnancy; Rats; Time Factors | 1977 |
Changes in the activities of the protoheme-synthesizing system during the growth of yeast under different conditions.
Topics: 5-Aminolevulinate Synthetase; Aerobiosis; Aminolevulinic Acid; Cell Division; Electron Transport Complex IV; Ferrochelatase; Heme; Oxygen Consumption; Porphobilinogen Synthase; Porphyrins; Saccharomyces cerevisiae; Spectrophotometry; Succinate Cytochrome c Oxidoreductase; Succinate-CoA Ligases; Temperature; Time Factors | 1977 |
A carbon monoxide-binding hemoprotein formed by heme accumulation in Escherichia coli.
Topics: Aerobiosis; Aminolevulinic Acid; Carbon Monoxide; Escherichia coli; Heme; Hemeproteins; Molecular Weight; NAD; Oxidation-Reduction; Protein Binding; Spectrophotometry; Succinates | 1977 |
Synthesis of haem and cytochrome c prosthetic group from delta-aminolaevulinate by the cell sap from rat liver.
Topics: Aminolevulinic Acid; Animals; Cytochrome c Group; Cytochromes; Heme; Kinetics; Levulinic Acids; Liver; Male; Porphyrins; Rats | 1977 |
Mevalonic acid as a precursor of the alkyl sidechain of heme a of cytochrome c oxidase in yeast Saccharomyces cerevisiae.
Topics: Aminolevulinic Acid; Electron Transport Complex IV; Heme; Mevalonic Acid; Mitochondria; Saccharomyces cerevisiae; Subcellular Fractions | 1978 |
Negative control of hemoglobin production in somatic cell hybrids due to heme deficiency.
Topics: Aminolevulinic Acid; Bone Marrow; Cell Line; Dimethyl Sulfoxide; Female; Genetic Linkage; Heme; Hemin; Hemoglobins; Hybrid Cells; Leukemia, Erythroblastic, Acute; RNA, Messenger; X Chromosome | 1978 |
Regulation of hemoglobin synthesis, iron metabolism, and maturation of Friend leukemic cells by 5-amino levulinic acid and hemin.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Culture Media; Heme; Hemin; Hemoglobins; Iron; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Levulinic Acids; Mice | 1979 |
The manipulation of cellular cytochrome and lipid composition in a haem mutant of Saccharomyces cerevisiae.
Topics: Aminolevulinic Acid; Cytochromes; Heme; Lipid Metabolism; Mutation; Oxygen Consumption; Porphyrins; Saccharomyces cerevisiae; Spectrum Analysis; Sterols | 1977 |
The effects of altered membrane sterol composition on oxidative phosphorylation in a haem mutant of Saccharomyces cerevisiae.
Topics: Aminolevulinic Acid; Fatty Acids, Unsaturated; Heme; Membrane Lipids; Mitochondria; Mutation; Oxidative Phosphorylation; Permeability; Protons; Saccharomyces cerevisiae; Sterols | 1977 |
The use of heme-deficient mutants to investigate mitochondrial function and biogenesis in yeast.
Topics: Aminolevulinic Acid; Heme; Kinetics; Mitochondria; Mutation; Oxygen Consumption; Phenotype; Saccharomyces cerevisiae; Species Specificity; Sterols; Thermodynamics | 1979 |
Isolation of haemin-requiring mutants of Escherichia coli K12.
Topics: Aminolevulinic Acid; Chromosome Mapping; Escherichia coli; Heme; Hemin; Hydroxymethylbilane Synthase; Mutation; Porphobilinogen Synthase; Porphyrins | 1979 |
Mutants of Escherichia coli K12 permeable to haemin.
Topics: Aminolevulinic Acid; Catalase; Culture Media; Escherichia coli; Heme; Hemin; Mutation; Porphyrins | 1979 |
An evaluation of the use of haem-biosynthetic parameters in the detection of industrial and environmental lead exposure: delta-aminolaevulinic acid and coproporphyrin [proceedings].
Topics: Aminolevulinic Acid; Coproporphyrins; Heme; Humans; Lead; Lead Poisoning; Levulinic Acids; Occupational Diseases; Porphyrins | 1979 |
Formation of cobalt protoporphyrin in the liver of rats. A mechanism for the inhibition of liver haem biosynthesis by inorganic cobalt.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cobalt; Electrophoresis, Polyacrylamide Gel; Heme; Liver; Male; Metals; Porphyrins; Protoporphyrins; Rats; Spectrophotometry | 1979 |
[Effect of hematin in acute porphyric relapse].
Topics: Acute Disease; Adult; Aminolevulinic Acid; Coproporphyrins; Heme; Hemin; Humans; Male; Porphobilinogen; Porphyrias; Uroporphyrins | 1979 |
Haem biosynthesis in cutaneous hepatic porphyria: comparison with alcoholism and liver disease.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrins; Erythrocytes; Ferrochelatase; Heme; Humans; Hydroxymethylbilane Synthase; Leukocytes; Liver Diseases, Alcoholic; Male; Porphobilinogen; Porphobilinogen Synthase; Porphyrias; Uroporphyrinogen Decarboxylase | 1979 |
Metabolic fate of exogenous delta-aminolevulinic acid in Dubin-Johnson syndrome.
Topics: Aminolevulinic Acid; Bile; Bilirubin; Coproporphyrinogens; Coproporphyrins; Heme; Humans; Jaundice, Chronic Idiopathic; Levulinic Acids; Liver; Protoporphyrins | 1979 |
The role of hemin in the regulation of heme synthesis by fetal mouse liver erythroblasts in culture.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Erythroblasts; Erythrocytes; Glycine; Heme; Hemin; Hemoglobins; Iron; Liver; Mice; Porphyrins; Protoporphyrins | 1979 |
Effect of anaerobiosis and glucose on the content of haem and its precursors in intact yeast cells.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Anaerobiosis; Culture Media; Glucose; Heme; Porphobilinogen Synthase; Yeasts | 1979 |
[Hematin treatment of acute intermittent porphyria. A case report (author's transl)].
Topics: Adolescent; Aminolevulinic Acid; Antihypertensive Agents; Electromyography; Female; Heme; Hemin; Humans; Infusions, Parenteral; Lung; Porphobilinogen; Porphyrias | 1979 |
Secretion of haem by hepatic parenchymal cells.
Topics: Albumins; Aminolevulinic Acid; Animals; Cells, Cultured; Cycloheximide; Extracellular Space; Heme; Hemopexin; In Vitro Techniques; Liver; Male; Perfusion; Rats; Secretory Rate | 1979 |
[Acute intermittent porphyria--a clinical review].
Topics: Acute Disease; Aminolevulinic Acid; Diagnosis, Differential; Heme; Humans; Porphobilinogen; Porphyrias | 1979 |
Studies on porphyrin-heme biosynthesis in organotypic cultures of chick dorsal root ganglion. I. Observations on neuronal and non-neuronal elements.
Topics: Aminolevulinic Acid; Animals; Autoradiography; Chick Embryo; Ganglia, Spinal; Heme; Levulinic Acids; Neurons; Organ Culture Techniques; Organ Specificity; Porphyrins; Spectrometry, Fluorescence | 1978 |
Heat inhibition of reticulocyte protein synthesis. Evidence for a mechanism independent of the hemin-controlled repressor.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Blood Proteins; Cell-Free System; Glycine; Heme; Hemin; Hot Temperature; Polyribosomes; Rabbits; Reticulocytes; Ribosomes | 1978 |
Lead and cadmium absorption among children near a nonferrous metal plant: a follow-up study of a test case.
Topics: Absorption; Adolescent; Air Pollution; Aminolevulinic Acid; Cadmium; Child; Environmental Exposure; Female; Follow-Up Studies; Heme; Humans; Lead; Male; Metallurgy; Population Surveillance; Porphobilinogen Synthase; Porphyrins | 1978 |
Evidence for a rapidly turned over pool of haem in isolated hepatocytes.
Topics: Aminolevulinic Acid; Animals; Biological Transport; Carrier Proteins; Cell Survival; Female; Heme; Iron; Kinetics; Levulinic Acids; Liver; Rats | 1978 |
Early labeled heme synthesis from delta-aminolevulinic acid-4-[14C] in rats: comparison with glycine-2-[14C].
Topics: Aminolevulinic Acid; Animals; Erythrocytes; Glycine; Heme; In Vitro Techniques; Levulinic Acids; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Rats; Time Factors | 1978 |
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Paralysis; Phenobarbital; Rats; Sleep; Zoxazolamine | 1978 |
Genetic and biochemical analysis of haemin dependent mutants of Bacillus subtilis.
Topics: Aminohydrolases; Aminolevulinic Acid; Bacillus subtilis; Carboxy-Lyases; Cell-Free System; Chromatography; Culture Media; Genes; Heme; Hemin; Lyases; Mutation; Oxidoreductases; Phenotype; Porphobilinogen Synthase; Porphyrins; Recombination, Genetic; Spectrophotometry; Streptomycin; Transduction, Genetic | 1975 |
The effect of cobalt on haemoglobin synthesis in primate reticulocytes.
Topics: Aminolevulinic Acid; Animals; Callitrichinae; Cobalt; Dose-Response Relationship, Drug; Globins; Haplorhini; Heme; Hemoglobins; Iron; Isoniazid; Reticulocytes | 1975 |
Heme biosynthesis in bacterium-protozoon symbioses: enzymic defects in host hemoflagellates and complemental role of their intracellular symbiotes.
Topics: Aminolevulinic Acid; Animals; Eukaryota; Glycine; Heme; Hydroxymethylbilane Synthase; Porphyrins; Rickettsiaceae; Species Specificity | 1975 |
Stimulation of bilirubin formation in liver of newborn rats by fasting and glucagon.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Bilirubin; Body Weight; Fasting; Glucagon; Heme; Liver; Mixed Function Oxygenases; Organ Size; Rats; Stimulation, Chemical | 1977 |
Studies in porphyria. VI. Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Heme; Humans; Hydroxymethylbilane Synthase; Levulinic Acids; Liver; Male; Mice; Organ Culture Techniques; Porphyrias; Porphyrins; Rats; Skin | 1977 |
Inhibition of haem synthesis caused by cobalt in rat liver. Evidence for two different sites of action.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Cobalt; Heme; Liver | 1977 |
Reversal of ineffective erythropoiesis in pernicious anaemia following vitamin B12 therapy.
Topics: Aged; Aminolevulinic Acid; Anemia, Pernicious; Bilirubin; Erythropoiesis; Female; Glycine; Heme; Humans; Male; Middle Aged; Vitamin B 12 | 1977 |
Pathogenesis of neural manifestations in acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Anura; Brain; Heme; Humans; In Vitro Techniques; Mice; Neurologic Manifestations; Porphobilinogen; Porphyrias; Rats | 1977 |
Role of haem in the synthesis and assembly of cytochrome P-450.
Topics: Aminolevulinic Acid; Animals; Apoenzymes; Binding Sites; Cytochrome P-450 Enzyme System; Heme; Hemin; Male; Microsomes, Liver; Phenobarbital; Rats; Triazoles | 1977 |
Effect of cobalt on the synthesis of liver microsomal cytochromes.
Topics: Aminolevulinic Acid; Animals; Cobalt; Cytochrome P-450 Enzyme System; Cytochromes; Heme; Leucine; Male; Microsomes, Liver; Protein Biosynthesis; Rats; Trypsin | 1977 |
Plumbism from airborne lead in a firing range. An unusual exposure to a toxic heavy metal.
Topics: Adolescent; Air Pollution; Aminolevulinic Acid; Coproporphyrins; Diagnosis, Differential; Erythrocytes; Heme; Humans; Lead; Lead Poisoning; Liver Diseases; Male; Occupational Diseases; Porphobilinogen Synthase; Porphyrias; Protoporphyrins | 1977 |
Effect of cobalt on synthesis of heme and cytochrome P-450 in the liver. Studies of adult rat hepatocytes in primary monolayer culture and in vivo.
Topics: Aminolevulinic Acid; Aniline Hydroxylase; Animals; Carbon Monoxide; Cells, Cultured; Cobalt; Cytochrome P-450 Enzyme System; Cytochromes; Heme; Liver; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry | 1976 |
Effect of lead on some parameters of the heme biosynthetic pathway in rat tissues in vivo.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Erythrocytes; Female; Hematocrit; Heme; Hemoglobins; Lead; Male; Porphobilinogen Synthase; Porphyrins; Pregnancy; Rats; Time Factors | 1976 |
Hematin treatment of acute porphyria. Early remission of an almost fatal relapse.
Topics: Acute Disease; Adult; Aminolevulinic Acid; Female; Follow-Up Studies; Heme; Hemin; Humans; Infusions, Parenteral; Porphobilinogen; Porphyrias; Remission, Spontaneous | 1976 |
Quantitation of ineffective erythropoiesis from the incorporation of [15N] delta-aminolaevulinic acid and [15N] glycine into early labelled bilirubin. I. Normal subjects.
Topics: Aged; Aminolevulinic Acid; Bilirubin; Erythropoiesis; Female; Glycine; Heme; Humans; Levulinic Acids; Male; Methods; Middle Aged | 1976 |
Quantitation of ineffective erythropoiesis from the incorporation of [15N] delta-aminolaevulinic acid and [15N] glycin into early labelled bilirubin. II. Anaemic patients.
Topics: Adolescent; Aged; Aminolevulinic Acid; Anemia; Anemia, Aplastic; Anemia, Hypochromic; Anemia, Sideroblastic; Bilirubin; Child; Erythropoiesis; Female; Glycine; Heme; Humans; Lesch-Nyhan Syndrome; Levulinic Acids; Male; Middle Aged | 1976 |
Induction of globin mRNA accumulation by hemin in cultured erythroleukemic cells.
Topics: Aminolevulinic Acid; Biliverdine; Cell Line; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Erythropoiesis; Globins; Heme; Hemin; Hemoglobins; Kinetics; Porphobilinogen; RNA, Messenger; RNA, Neoplasm | 1976 |
Cytochrome P-450 heme and the regulation of hepatic heme oxygenase activity.
Topics: Aminolevulinic Acid; Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Endotoxins; Heme; Kinetics; Liver; Male; Microsomes, Liver; Oxygenases; Rats | 1976 |
Binding by proteins of the rat liver cytosol of compounds derived in vivo from the haem precursor 5-aminolaevulinic acid.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Carrier Proteins; Cytosol; Heme; Levulinic Acids; Liver; Mixed Function Oxygenases; Rats | 1976 |
Formation and structures of bile pigments from non-mammalian sources.
Topics: Aminolevulinic Acid; Animals; Bile Pigments; Binding Sites; Eukaryota; Glycine; Heme; Iron; Lepidoptera; Light; Protoporphyrins | 1976 |
The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase.
Topics: Aminolevulinic Acid; Animals; Cobalt; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Kidney; Male; Metals; Microsomes, Liver; Mitochondria, Liver; Myocardium; Oxygenases; Rats | 1976 |
Hepatic heme metabolism in selenium-deficient rats: effect of phenobarbital.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Selenium; Spleen | 1976 |
Assay in situ of yeast enzymes involved in protohaem synthesis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Candida; Cold Temperature; Digitonin; Heme; Lyases; Permeability; Porphobilinogen Synthase; Porphyrins; Protoporphyrins; Saccharomyces cerevisiae; Spectrophotometry; Toluene; Ultrafiltration | 1975 |
The degradative effects of porphyrins and heme compounds on components of the microsomal mixed function oxidase system.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Darkness; Deuterium; Heme; Hemeproteins; Male; Metalloproteins; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Porphyrins; Rats | 1975 |
Neurochemical aspects of porphyria. Studies on the possible neurotoxicity of delta-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Behavior, Animal; Brain; Carbon Radioisotopes; Cerebral Ventricles; Female; Heme; Injections; Levulinic Acids; Liver; Lysine; Methionine; Nephrectomy; Nerve Tissue Proteins; Rats; Sulfur Radioisotopes | 1975 |
Effects of hematin in hepatic porphyria. Further studies.
Topics: Adult; Aminolevulinic Acid; Female; Heme; Hemin; Humans; Infusions, Parenteral; Liver; Male; Middle Aged; Porphobilinogen; Porphyrias; Porphyrins; Recurrence | 1975 |
Some observations on chlorophyll(ide) synthesis by isolated etioplasts.
Topics: Aminolevulinic Acid; Chlorophyll; Heme; Light; Photosynthesis; Plants; Porphyrins; Spectrophotometry | 1975 |
Indicators of internal dose of lead in relation to derangement in heme synthesis.
Topics: Aminolevulinic Acid; Chelating Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Erythrocytes; Heme; Humans; Indicators and Reagents; Infant; Lead; Protoporphyrins | 1975 |
Anesthesia and the porphyrias.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Ammonia-Lyases; Anesthesia; Anesthetics; Child; Chlordiazepoxide; Cytochrome P-450 Enzyme System; Demyelinating Diseases; Diazepam; Heme; Humans; Neostigmine; Pentazocine; Porphobilinogen; Porphyrias; Thiopental | 1975 |
Regulation of rat liver tryptophan pyrrolase by its cofactor haem: Experiments with haematin and 5-aminolaevulinate and comparison with the substrate and hormonal mechanisms.
Topics: Aminolevulinic Acid; Apoenzymes; Cycloheximide; Dactinomycin; Hematinics; Heme; Hydrocortisone; Liver; Porphyrias; Porphyrinogens; Puromycin; Tryptophan; Tryptophan Oxygenase | 1975 |
Incorporation of ALA-14C in circulating bilirubin and hemoglobin heme of hepatectomized dogs.
Topics: Aminolevulinic Acid; Animals; Bilirubin; Dogs; Heme; Hemin; Hemoglobins; Hepatectomy; Liver | 1975 |
Effects by heme, insulin, and serum albumin on heme and protein synthesis in chick embryo liver cells cultured in a chemically defined medium, and a spectrofluorometric assay for porphyrin composition.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cattle; Cells, Cultured; Chick Embryo; Enzyme Induction; Fetus; Heme; Humans; Insulin; Liver; Porphyrins; Protoporphyrins; Serum Albumin; Serum Albumin, Bovine; Spectrometry, Fluorescence | 1975 |
Mechanism and stereochemistry of vinyl-group formation in haem biosynthesis.
Topics: Aminolevulinic Acid; Anemia; Animals; Chickens; Heme; Ketoglutaric Acids; Stereoisomerism; Succinates; Vinyl Compounds | 1976 |
Lowered levels of colicin Ia membrane receptors in an Escherichia coli mutant defective in heme biosynthesis.
Topics: Aminolevulinic Acid; Binding Sites; Cell Membrane; Colicins; Heme; Mutation; Protein Binding; Viral Proteins | 1976 |
Nitrate reductase activity in heme-deficient mutants of Staphylococcus aureus.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Cell Membrane; Cytoplasm; Dithiothreitol; Glucose; Glycerol; Heme; Hemin; Mutation; Nitrate Reductases; Nitrates; Oxygen Consumption; Staphylococcus aureus | 1976 |
Haem-binding proteins of the rat liver cytosol.
Topics: Aminolevulinic Acid; Animals; Binding Sites; Carrier Proteins; Cytosol; Glutathione Transferase; Heme; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Protein Binding; Proteins; Rats | 1976 |
Protective effect of zinc on heme biosynthesis disturbances in rabbits after administration per os of tin.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Coproporphyrins; Drug Interactions; Female; Heme; Porphobilinogen Synthase; Rabbits; Tin; Tin Compounds; Zinc | 1992 |
The genes required for heme synthesis in Salmonella typhimurium include those encoding alternative functions for aerobic and anaerobic coproporphyrinogen oxidation.
Topics: Aerobiosis; Aminolevulinic Acid; Anaerobiosis; Chromatography, High Pressure Liquid; Coproporphyrinogen Oxidase; Coproporphyrinogens; DNA Transposable Elements; Genes, Bacterial; Heme; Mutagenesis, Insertional; Oxidation-Reduction; Salmonella typhimurium | 1992 |
delta-Aminolevulinate couples cycA transcription to changes in heme availability in Rhodobacter sphaeroides.
Topics: Aminolevulinic Acid; Cytochrome c Group; Cytochromes c2; Escherichia coli; Gene Expression Regulation, Bacterial; Heme; Mutation; Plasmids; Recombinant Fusion Proteins; Rhodobacter sphaeroides; Transcription, Genetic | 1992 |
de novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Glutamates; Glutamic Acid; Heme; Heptanoates; Isoleucine; Plasmodium falciparum; Porphobilinogen Synthase; Protein Biosynthesis | 1992 |
Gene-dose-dependent expression of soluble mammalian cytochrome b5 in Escherichia coli.
Topics: Aminolevulinic Acid; Apoproteins; Codon; Cytochromes b5; Escherichia coli; Gene Amplification; Gene Expression Regulation, Bacterial; Genes, Synthetic; Heme; Recombinant Fusion Proteins | 1992 |
Disturbances in heme biosynthesis in rabbits after administration per os of low doses of tin or lead.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Coproporphyrins; Female; Heme; Lead; Porphobilinogen Synthase; Rabbits; Tin | 1992 |
Bilirubin production and conjugation from newly formed heme in isolated rat hepatocytes.
Topics: Aminolevulinic Acid; Animals; Bile Pigments; Bilirubin; Cells, Cultured; Cobalt; Heme; Hemin; Kinetics; Liver; Male; Metalloporphyrins; Protoporphyrins; Rats; Rats, Sprague-Dawley | 1992 |
Porphyrin metabolism in some malignant diseases.
Topics: Adult; Aminolevulinic Acid; Child; Coproporphyrins; Erythrocytes; Female; Ferrochelatase; Heme; Hodgkin Disease; Humans; Hydroxymethylbilane Synthase; Lymphoma, Non-Hodgkin; Male; Porphobilinogen; Porphobilinogen Synthase; Porphyrins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Uroporphyrins | 1992 |
[Evaluation of the effects of reduced glutathione in subjects with acquired and congenital changes in heme biosynthesis].
Topics: Aminolevulinic Acid; Coproporphyrins; Glutathione; Heme; Humans; Lead Poisoning; Porphyrias; Porphyrins; Skin Diseases; Time Factors; Uroporphyrins | 1992 |
Stimulation by heme of steryl ester synthase and aerobic sterol exclusion in the yeast Saccharomyces cerevisiae.
Topics: Acyltransferases; Aerobiosis; Aminolevulinic Acid; Esterification; Fatty Acids, Unsaturated; Heme; Lovastatin; Methionine; Saccharomyces cerevisiae; Sterol O-Acyltransferase; Sterols | 1992 |
Levels of trace elements in the serum and erythrocytes and some parameters of erythrocyte heme metabolism (FEP, ALA-D, ALA-U) in copper foundry workers.
Topics: Adult; Aminolevulinic Acid; Copper; Dust; Erythrocytes; Heme; Humans; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Occupational Exposure; Porphobilinogen Synthase; Protoporphyrins; Trace Elements | 1991 |
Aerobic growth and respiration of a delta-aminolevulinic acid synthase (hemA) mutant of Bradyrhizobium japonicum.
Topics: 5-Aminolevulinate Synthetase; Aerobiosis; Aminolevulinic Acid; Cytochromes; Heme; Kinetics; Mutation; Oxygen Consumption; Peroxidase; Rhizobiaceae; Spectrum Analysis | 1991 |
Biosynthesis of delta-aminolevulinic acid and the regulation of heme formation by immature erythroid cells in man.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Blotting, Northern; Feedback; Hematologic Diseases; Heme; Humans; Kinetics; Protein Synthesis Inhibitors; Protoporphyrins; Reticulocytes; RNA, Messenger | 1991 |
Studies on the decrease of liver cytochrome P-450 content by triiodothyronine.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Heme; Humans; Hydroxymethylbilane Synthase; Male; Microsomes, Liver; Porphobilinogen Synthase; Proteins; Rats; Rats, Inbred Strains; Serum Albumin; Triiodothyronine | 1991 |
Tin(Sn+4)-diiododeuteroporphyrin; an in vitro and in vivo inhibitor of heme oxygenase with substantially reduced photoactive properties.
Topics: Aminolevulinic Acid; Animals; Animals, Newborn; Biliary Tract; Bilirubin; Heme; Heme Oxygenase (Decyclizing); Hyperbilirubinemia; In Vitro Techniques; Kinetics; Male; Metalloporphyrins; Photochemistry; Rats; Rats, Inbred Strains; Spectrophotometry | 1991 |
Elevation of hormone-binding globulins in acute intermittent porphyria.
Topics: Adolescent; Adult; Aminolevulinic Acid; Arginine; Carrier Proteins; Heme; Humans; Hydrocortisone; Liver Diseases; Porphobilinogen; Porphyrias; Prospective Studies; Sex Hormone-Binding Globulin; Testosterone; Thyroxine-Binding Proteins | 1990 |
On rat renal aminolevulinate transport and metabolism in experimental Fanconi syndrome.
Topics: Amino Acid Metabolism, Inborn Errors; Aminolevulinic Acid; Animals; Biological Transport, Active; Fanconi Syndrome; Heme; Heptanoates; In Vitro Techniques; Kidney Tubules; Male; Maleates; Microvilli; Porphobilinogen Synthase; Rats; Rats, Inbred Strains; Tyrosine | 1990 |
Protein-mediated efflux of heme from isolated rat liver mitochondria.
Topics: Aminolevulinic Acid; Animals; Glutathione Transferase; Heme; Hemeproteins; Liposomes; Mitochondria, Liver; Protein Binding; Rats; Serum Albumin | 1990 |
Pharmacological activities of delta-aminolaevulinic acid, protoporphyrin IX and haemin in isolated preparations of rabbit gastric fundus and jejunum.
Topics: Aminolevulinic Acid; Animals; Female; Gastric Fundus; Heme; Hemin; In Vitro Techniques; Jejunum; Levulinic Acids; Male; Muscle Contraction; Muscle, Smooth; Porphyrins; Prazosin; Protoporphyrins; Rabbits | 1990 |
L-Alanine: 4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver.
Topics: Alanine; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Chick Embryo; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Liver; Male; Phenobarbital; Porphyrins; Rats; Rats, Inbred Strains; Transaminases; Valerates | 1990 |
[Evaluation of porphyrinogenic effect of lindane in rats].
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Heme; Hexachlorocyclohexane; Levulinic Acids; Liver; Male; Porphobilinogen; Porphyrias; Porphyrins; Rats; Rats, Inbred Strains | 1986 |
Inhibition of cellular iron uptake by haem in mouse erythroleukaemia cells.
Topics: Acetamides; Aminolevulinic Acid; Animals; Cell Differentiation; Cells, Cultured; Glycine; Heme; Hemin; Iron; Iron Radioisotopes; Leukemia, Erythroblastic, Acute; Mice; Time Factors; Transferrin | 1989 |
Cytosine arabinoside plus hemin treatment of a human erythroid cell line, KMOE, strongly induces embryonic, fetal, and adult beta-like globin genes.
Topics: Aminolevulinic Acid; Cytarabine; Dimethyl Sulfoxide; Drug Synergism; Erythroid Precursor Cells; Erythropoietin; Gene Expression Regulation; Globins; Heme; Hemin; Humans; Leukemia, Erythroblastic, Acute; RNA, Messenger; Stimulation, Chemical; Tumor Cells, Cultured | 1989 |
Pharmacological effects of haem biosynthetic intermediates: actions of delta-aminolaevulinic acid in the rat jejunum.
Topics: Aminolevulinic Acid; Animals; Bicuculline; Heme; In Vitro Techniques; Jejunum; Levulinic Acids; Muscle, Smooth; Rats | 1989 |
Heme-deficient mutants of Salmonella typhimurium: two genes required for ALA synthesis.
Topics: Aminolevulinic Acid; Chromosome Mapping; Cysteine; Cytochromes; Genes, Bacterial; Genetic Complementation Test; Heme; Mutation; Salmonella typhimurium; Transcription, Genetic; Vitamin B 12 | 1989 |
Haem biosynthesis in the unconjugated hyperbilirubinaemias: observations in the Gunn rat model.
Topics: Aminolevulinic Acid; Animals; Bilirubin; Chromatography; Chromatography, High Pressure Liquid; Feces; Heme; Hyperbilirubinemia, Hereditary; Porphyrins; Protoporphyrins; Rats; Rats, Gunn; Rats, Inbred Strains | 1989 |
Kinetics of the intracellular availability of heme after supplementing a heme-deficient yeast mutant with 5-aminolevulinate.
Topics: Aminolevulinic Acid; Cytochrome c Group; Cytochromes; Cytochromes c; Cytoplasm; Gene Expression Regulation; Heme; Levulinic Acids; Oxygen Consumption; Protein Processing, Post-Translational; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Transcription, Genetic | 1986 |
Effect of mitochondrial cytochromes and haem content on cytochrome P450 in Saccharomyces cerevisiae.
Topics: Aminolevulinic Acid; Cytochrome P-450 Enzyme System; Cytochromes; Electron Transport Complex IV; Heme; Microsomes; Mitochondria; Mutation; Saccharomyces cerevisiae | 1986 |
Myeloperoxidase precursors incorporate heme.
Topics: Aminolevulinic Acid; Cell Line; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Granulocytes; Heme; Humans; Immunosorbent Techniques; Leucine; Levulinic Acids; Molecular Weight; Peptide Fragments; Peroxidase; Protein Precursors; Serine Endopeptidases | 1987 |
A haemoprotein is not involved in the control by oxygen of enteric nitrogenase synthesis.
Topics: Aminolevulinic Acid; Bacterial Proteins; Escherichia coli; Heme; Mutation; Nitrogenase; Oxygen; Plasmids | 1988 |
The effects of chronic carbamazepine treatment of haem biosynthesis in man and rat.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Aged; Aminolevulinic Acid; Ammonia-Lyases; Animals; Carbamazepine; Female; Heme; Humans; Hydroxymethylbilane Synthase; Leukocytes; Male; Middle Aged; Porphobilinogen; Porphobilinogen Synthase; Porphyrins; Rats; Rats, Inbred Strains | 1988 |
Regulation of ergosterol biosynthesis and sterol uptake in a sterol-auxotrophic yeast.
Topics: Aminolevulinic Acid; Biological Transport; Cholesterol; Ergosterol; Heme; Hydroxymethylglutaryl CoA Reductases; Lipids; Mutation; Saccharomyces cerevisiae; Squalene; Sterols | 1987 |
Haem synthesis during cytochrome P-450 induction in higher plants. 5-Aminolaevulinic acid synthesis through a five-carbon pathway in Helianthus tuberosus tuber tissues aged in the dark.
Topics: Allylglycine; Aminolevulinic Acid; Chlorophyll; Cyclohexanecarboxylic Acids; Cytochrome P-450 Enzyme System; Darkness; Electron Transport; Enzyme Induction; Helianthus; Heme; Levulinic Acids; Light; Peroxidases; Plant Proteins; Pyridoxal Phosphate | 1988 |
Treatment of acute hepatic porphyria with hematin.
Topics: Acute Disease; Adult; Aged; Aminolevulinic Acid; Female; Heme; Hemin; Humans; Liver Diseases; Male; Middle Aged; Porphobilinogen; Porphyrias | 1988 |
Biosynthesis of heme in immature erythroid cells. The regulatory step for heme formation in the human erythron.
Topics: Adolescent; Adult; Aminolevulinic Acid; Anemia, Sickle Cell; Animals; Bone Marrow; Child; Cycloheximide; Feedback; Female; Globins; Glycine; Heme; Humans; Iron Radioisotopes; Kinetics; Male; Methionine; Middle Aged; Protein Biosynthesis; Rabbits; Reticulocytes; Transferrin | 1988 |
Haem synthesis from exogenous 5-aminolaevulinate in cultured chick-embryo hepatocytes. Effects of inducers of cytochromes P-450.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Induction; Heme; Levulinic Acids; Liver; Methylcholanthrene; Porphobilinogen; Porphyrins | 1987 |
Lead effects on the heme biosynthetic pathway. Relationship to toxicity.
Topics: Aminolevulinic Acid; Antipyrine; Cytochromes; Heme; Humans; Lead Poisoning; Models, Biological; Porphyrias; Porphyrins | 1987 |
Enhancement by hemin of the sensitivity of K562 human leukemic cells to 1-beta-D-arabinofuranosylcytosine.
Topics: Aminolevulinic Acid; Butyrates; Cell Differentiation; Cell Line; Cytarabine; Daunorubicin; Deoxyguanosine; Doxorubicin; Drug Synergism; Erythropoiesis; Heme; Hemin; Humans; Hydroxyurea; Leukemia, Myeloid; Methotrexate; Thymidine; Vincristine | 1986 |
Control of heme synthesis during Friend cell differentiation: role of iron and transferrin.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Friend murine leukemia virus; Glycine; Heme; Humans; Iron; Leukemia, Erythroblastic, Acute; Mice; Transferrin | 1986 |
Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources.
Topics: Aminolevulinic Acid; Animals; Carbon Monoxide; Heme; Hemin; Metalloporphyrins; Oxidation-Reduction; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains | 1987 |
Influence of chronic alcohol consumption on hepatic heme and porphyrin metabolism.
Topics: 5-Aminolevulinate Synthetase; Alcohol Dehydrogenase; Alcoholism; Aminolevulinic Acid; Animals; Catalase; Cytosol; Ethanol; Female; Heme; Liver; Microsomes, Liver; Porphyrins; Proteins; Rats; Rats, Inbred Strains | 1987 |
Pharmacological effects of haem biosynthetic intermediates in isolated intestinal preparations.
Topics: Aminolevulinic Acid; Animals; Colon; Coproporphyrins; Female; Glycine; Heme; Hemin; In Vitro Techniques; Intestinal Mucosa; Intestines; Jejunum; Male; Muscle Contraction; Porphobilinogen; Protoporphyrins; Rabbits; Succinates | 1987 |
Interaction of tin and zinc in some processes of heme biosynthesis in rabbits.
Topics: Aminolevulinic Acid; Animals; Coproporphyrins; Drug Interactions; Female; Heme; Lead; Porphobilinogen Synthase; Rabbits; Tin; Zinc | 1986 |
Myoglobin expression in L6 muscle cells. Role of differentiation and heme.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Cell Line; Cytarabine; DNA; Ferric Compounds; Heme; Hemin; Heptanoates; Muscles; Myoglobin; Porphobilinogen Synthase; Rats | 1986 |
Involvement of heme biosynthesis in control of sterol uptake by Saccharomyces cerevisiae.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Biological Transport; Heme; Hemeproteins; Intramolecular Transferases; Isomerases; Mutation; Saccharomyces cerevisiae; Sterols | 1985 |
Heme synthesis in Crithidia deanei: influence of the endosymbiote.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Crithidia; Heme; Porphyrins; Rickettsiaceae; Succinate-CoA Ligases; Symbiosis | 1985 |
Detection of delta-aminolevulinic acid, porphobilinogen and porphyrins related to heme biosynthesis by high-performance liquid chromatography.
Topics: Aminolevulinic Acid; Chromatography, High Pressure Liquid; Heme; Hydrogen-Ion Concentration; Indicators and Reagents; Levulinic Acids; o-Phthalaldehyde; Porphobilinogen; Porphyrins | 1986 |
Inhibition of the biosynthesis of uroporphyrinogen and heme in rat liver during obstructive jaundice produced by bile duct ligation.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cholestasis, Extrahepatic; Common Bile Duct; Cytochrome P-450 Enzyme System; Heme; Hydroxymethylbilane Synthase; Hyperbilirubinemia; Liver; Male; Microsomes, Liver; Porphyrinogens; Rats; Rats, Inbred Strains; Uroporphyrinogens | 1986 |
Enzymatic conversion of glutamate to delta-aminolevulinate in soluble extracts of the unicellular green alga, Chlorella vulgaris.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Binding Sites; Catalysis; Chlorella; Glutamates; Heme; Levulinic Acids; NADP; Nucleotides; Solutions; Temperature | 1985 |
Alterations in hepatic heme metabolism in fish exposed to sublethal cadmium levels.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cadmium; Fishes; Heme; Liver; Time Factors | 1985 |
Conversion of 5-aminolaevulinate into haem by homogenates of human liver. Comparison with rat and chick-embryo liver homogenates.
Topics: Aminolevulinic Acid; Animals; Chick Embryo; Deferoxamine; Dithiothreitol; Ferrous Compounds; Heme; Humans; Kinetics; Levulinic Acids; Liver; Models, Biological; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Inbred Strains | 1985 |
Hepatic heme metabolism and cytochrome P450 in cirrhotic rat liver.
Topics: Aminolevulinic Acid; Animals; Biological Availability; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Heme; Liver; Liver Cirrhosis; Male; Rats; Rats, Inbred Strains; Tryptophan Oxygenase | 1985 |
Stimulation of 5-aminolevulinic acid metabolism by uroporphyrinogen I in rat liver homogenate.
Topics: Aminolevulinic Acid; Animals; Cell-Free System; Heme; In Vitro Techniques; Levulinic Acids; Liver; Male; Porphobilinogen; Porphyrinogens; Porphyrins; Rats; Rats, Inbred Strains; Uroporphyrinogens | 1985 |
Acquisition of iron from transferrin regulates reticulocyte heme synthesis.
Topics: Aminolevulinic Acid; Animals; Carbon Radioisotopes; Glycine; Heme; Iron; Iron Chelating Agents; Isoniazid; Kinetics; Rabbits; Reticulocytes; Transferrin | 1985 |
"Glucose effect" and rate limiting function of uroporphyrinogen synthase on porphyrin metabolism in hepatocyte culture: relationship with human acute hepatic porphyrias.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Ammonia-Lyases; Animals; Cells, Cultured; Chick Embryo; Glucose; Heme; Humans; Hydroxymethylbilane Synthase; Kinetics; Liver; Liver Diseases; Meprobamate; Porphobilinogen; Porphyrias; Porphyrins | 1985 |
Incorporation of heme to microsomal cytochrome P-450 in the absence of protein biosynthesis.
Topics: Aminolevulinic Acid; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Cytosol; Heme; In Vitro Techniques; Leucine; Male; Microsomes, Liver; Phenobarbital; Precipitin Tests; Rats; Rats, Inbred Strains | 1985 |
Studies on rat catalase. VII. Double-labeling of catalase by 14C-leucine and 3H-delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Antigen-Antibody Reactions; Carbon Radioisotopes; Catalase; Cell-Free System; Chromatography, DEAE-Cellulose; Cytoplasmic Granules; Cytosol; Heme; Isotope Labeling; Kinetics; Leucine; Levulinic Acids; Liver; Microsomes; Rabbits; Rats; Ribosomes; Spectrophotometry, Ultraviolet; Time Factors; Tritium | 1974 |
Ethanol inhibition of haemoglobin synthesis: in vitro evidence for a haem correctable defect in normal subjects and in alcoholics.
Topics: Alcoholism; Aminolevulinic Acid; Bone Marrow; Bone Marrow Cells; Chromatography; Ethanol; Globins; Heme; Hemoglobins; Humans; In Vitro Techniques; Leucine; Pyridoxine; Reticulocytes; Tritium | 1974 |
Effect of cobalt on the synthesis and degradation of hepatic catalase in vivo.
Topics: Aminolevulinic Acid; Animals; Catalase; Cobalt; Cytosol; Glycine; Heme; Kinetics; Leucine; Liver; Male; Mitochondria, Liver; Rats | 1974 |
Comparative aspects of porphyria in man and animals.
Topics: Adult; Aminolevulinic Acid; Animals; Cattle; Drug Stability; Female; Genes, Recessive; Heme; Heterozygote; Hot Temperature; Humans; Isomerases; Kinetics; Male; Pedigree; Porphobilinogen; Porphyrias; Porphyrins; Reticulocytes; Sciuridae | 1974 |
Isotopic studies of porphyrin and heme metabolism: bonanzas and pitfalls.
Topics: Aminolevulinic Acid; Anemia, Hemolytic; Antimetabolites; Bilirubin; Carbon Radioisotopes; Erythrocytes; Feces; Glycine; Hematocrit; Heme; Hemoglobins; Humans; Iron; Iron Radioisotopes; Isotope Labeling; Jaundice; Methods; Nitrogen Isotopes; Phagocytosis; Phenylhydrazines; Porphyrias; Porphyrins; Reticulocytes; Time Factors; Tritium | 1974 |
Delta-aminolevulinic acid transport and synthesis, porphyrin synthesis and heme catabolism in chick embryo liver and heart cells.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Biological Transport; Carbon Radioisotopes; Chick Embryo; Chromatography, Ion Exchange; Coenzyme A Ligases; Dicarboxylic Acids; Enzyme Induction; Heart; Heme; Kinetics; Levulinic Acids; Liver; Myocardium; Organ Specificity; Oxygenases; Porphyrins; Pyridines; Regression Analysis; Rhodobacter sphaeroides; Succinates; Time Factors | 1974 |
Heme regulation of HeLa cell transferrin receptor number.
Topics: Aminolevulinic Acid; Enzyme Induction; HeLa Cells; Heme; Heme Oxygenase (Decyclizing); Humans; Iron; Kinetics; Receptors, Cell Surface; Receptors, Transferrin; Transferrin | 1984 |
Role of altered heme synthesis in lead neurotoxicity.
Topics: Aminolevulinic Acid; gamma-Aminobutyric Acid; Heme; Humans; Lead Poisoning; Nervous System Diseases; Neurotransmitter Agents | 1980 |
Iron and the liver: acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Dextrans; Drug Synergism; Heme; Iron; Liver; Male; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Inbred Strains; Uroporphyrinogen Decarboxylase | 1983 |
Identification of porphyrin present in apo-cytochrome C oxidase of copper-deficient yeast cells.
Topics: Aminolevulinic Acid; Apoenzymes; Apoproteins; Chromatography, Thin Layer; Copper; Electron Transport Complex IV; Electrophoresis, Polyacrylamide Gel; Heme; Mitochondria; Molecular Weight; Porphyrins; Saccharomyces cerevisiae; Spectrophotometry | 1980 |
7-Ethoxycoumarin deethylase activity as a convenient measure of liver drug metabolizing enzymes: regulation in cultured rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aminolevulinic Acid; Animals; Bucladesine; Cells, Cultured; Dexamethasone; Enzyme Induction; Glucagon; Heme; Insulin; Liver; Methylcholanthrene; Niacinamide; Oxygenases; Phenobarbital; Pyridines; Rats; Rats, Inbred Strains | 1984 |
The biochemical basis of the acute porphyrias.
Topics: Acute Disease; Aminolevulinic Acid; Heme; Humans; Nervous System Diseases; Porphyrias; Porphyrins | 1983 |
Effect of ovulation on haem metabolism in rabbits.
Topics: Aminolevulinic Acid; Animals; Carbon Monoxide; Estrus; Female; Glycine; Heme; Ovulation; Pregnancy; Rabbits | 1984 |
An experimental model of postnatal jaundice in the suckling rat. Suppression of induced hyperbilirubinemia by Sn-protoporphyrin.
Topics: Aging; Aminolevulinic Acid; Animals; Bilirubin; Disease Models, Animal; Female; Heme; Heme Oxygenase (Decyclizing); Humans; Infant, Newborn; Jaundice, Neonatal; Liver; Male; Rats; Rats, Inbred Strains | 1984 |
Effects of 1,2-dibromo-3-chloropropane on hepatic heme synthesis.
Topics: Aminolevulinic Acid; Animals; Antinematodal Agents; Carbon Radioisotopes; Catalase; Cytochrome P-450 Enzyme System; Glutathione; Heme; Heme Oxygenase (Decyclizing); Hydroxymethylbilane Synthase; In Vitro Techniques; Liver; Male; Propane; Rats; Rats, Inbred Strains | 1984 |
[Chronic lead exposure. Its repercussion on indicators of heme synthesis and iron metabolism].
Topics: Adolescent; Adult; Aminolevulinic Acid; Child; Child, Preschool; Female; Food Handling; Heme; Humans; Iron; Lead; Lead Poisoning; Male; Middle Aged; Occupational Diseases; Protoporphyrins | 1983 |
Regulation of heme metabolism and cytochrome P-450 levels in primary culture of rat hepatocytes in a defined medium.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cells, Cultured; Culture Media; Cytochrome P-450 Enzyme System; Female; Heme; Liver; Male; Rats; Rats, Inbred Strains | 1984 |
Porphyrin-heme biosynthesis in organotypic cultures of mouse dorsal root ganglia. Effects of heme and lead on porphyrin synthesis and peripheral myelin.
Topics: Aminolevulinic Acid; Animals; Axons; Fetus; Ganglia, Spinal; Heme; Lead; Lead Poisoning; Mice; Myelin Sheath; Neurons; Organ Culture Techniques; Porphyrins | 1984 |
Studies on patients with polychlorinated biphenyl poisoning. 2. Determination of urinary coproporphyrin, uroporphyrin, delta-aminolevulinic acid and porphobilinogen.
Topics: Aminolevulinic Acid; Coproporphyrins; Heme; Humans; Polychlorinated Biphenyls; Porphobilinogen; Uroporphyrins | 1980 |
Metabolism of heme and bilirubin in rat and human small intestinal mucosa.
Topics: Aminolevulinic Acid; Animals; Bilirubin; Epithelial Cells; Epithelium; Glucuronates; Glucuronosyltransferase; Heme; Humans; Intestinal Mucosa; Jejunum; Liver; Male; Rats; Rats, Inbred Strains; Uridine Diphosphate Glucuronic Acid | 1982 |
Biosynthesis of 5-aminolevulinic acid and heme from 4,5-dioxovalerate in the rat.
Topics: Aminolevulinic Acid; Anemia, Hemolytic; Animals; Glycine; Heme; Levulinic Acids; Liver; Male; Phenylhydrazines; Rats; Rats, Inbred Strains; Valerates | 1983 |
Pathogenesis and treatment of acute intermittent porphyria: discussion paper.
Topics: Acute Disease; Aminolevulinic Acid; Blood-Brain Barrier; Heme; Humans; Liver Diseases; Porphobilinogen; Porphyrias | 1983 |
Factors affecting haem degradation in rat brain.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Biotransformation; Brain; Female; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Lead; Liver; Phenobarbital; Rats | 1980 |
Porphyrogenic effects and induction of heme oxygenase in vivo by delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Brain; Chick Embryo; Enzyme Induction; Female; Heme; Heme Oxygenase (Decyclizing); Levulinic Acids; Liver; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; Porphyrins; Rats; Sex Factors; Species Specificity | 1981 |
The role of haem biosynthetic and degradative enzymes in erythroid colony development: the effect of haemin.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Colony-Forming Units Assay; Cycloheximide; Enzyme Activation; Erythropoiesis; Heme; Heme Oxygenase (Decyclizing); Hemin; Mice; Mice, Inbred BALB C; Porphobilinogen Synthase; Time Factors | 1982 |
Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Heme; Hemeproteins; Liver; Male; Microsomes, Liver; Mitochondria; Mixed Function Oxygenases; Phenobarbital; Rats | 1980 |
Biosynthesis of porphyrins and heme from gamma, delta-dioxovalerate by intact hepatocytes.
Topics: Alanine; Aminolevulinic Acid; Animals; Cells, Cultured; Glycine; Heme; Keto Acids; Levulinic Acids; Liver; Male; Porphyrins; Rats; Succinates; Succinic Acid; Valerates | 1981 |
Environmental and drug factors in hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Allyl Compounds; Aminolevulinic Acid; Barbiturates; Chemical and Drug Induced Liver Injury; Dicarbethoxydihydrocollidine; Drug-Related Side Effects and Adverse Reactions; Environmental Exposure; Enzyme Activation; Estrogens; Ethanol; Griseofulvin; Heme; Humans; Hydrocarbons, Chlorinated; Iron; Liver; Porphyrias; Porphyrinogens | 1982 |
The effect of delta-aminolevulinate on catalase T-messenger RNA levels in delta-aminolevulinate synthase-defective mutants of Saccharomyces cerevisiae.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Catalase; Heme; Levulinic Acids; Mutation; Plants; Protein Biosynthesis; RNA, Messenger; Saccharomyces cerevisiae; Triticum | 1980 |
Isolation and characterization of hemin-permeable, envelope-defective mutants of Salmonella typhimurium.
Topics: Aminolevulinic Acid; Anti-Bacterial Agents; Bacterial Proteins; Cell Membrane; Cell Wall; Drug Resistance, Microbial; Electrophoresis, Polyacrylamide Gel; Heme; Hemin; Membrane Proteins; Mutation; Salmonella typhimurium; Transduction, Genetic | 1981 |
Assembly of functional b-type cytochromes in membranes from a 5-aminolaevulinic acid-requiring mutant of Escherichia coli.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Cell Membrane; Cytochrome b Group; Cytochromes; Escherichia coli; Heme; Hemin; Levulinic Acids; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Spectrophotometry | 1981 |
Alterations in haem biosynthesis during the human menstrual cycle: studies in normal subjects and patients with latent and active acute intermittent porphyria.
Topics: 5-Aminolevulinate Synthetase; Adrenal Cortex Hormones; Adult; Aminolevulinic Acid; Erythrocytes; Female; Heme; Humans; Hydroxymethylbilane Synthase; Leukocytes; Liver Diseases; Male; Menstruation; Middle Aged; Porphobilinogen; Porphyrias | 1982 |
The effect of inorganic lead on heptic biochemical and ultrastructural changes produced by phenobarbital.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Heme; Lead; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1982 |
The role of cytosolic proteins in the intracellular transport of haem in rat liver. A dual-label approach.
Topics: Aminolevulinic Acid; Animals; Carbon Radioisotopes; Carrier Proteins; Cytosol; Heme; Intracellular Fluid; Liver; Male; Rats; Rats, Inbred Strains; Subcellular Fractions; Tritium | 1982 |
Heme biosynthesis in the heart.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Glycine; Heme; In Vitro Techniques; Male; Myocardium; Perfusion; Rats; Rats, Inbred Strains | 1982 |
Studied on cerebellar haem metabolism in the rat in vivo.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cerebellum; Feedback; Heme; Heptanoates; Kinetics; Male; Porphobilinogen Synthase; Porphyrins; Rats; Rats, Inbred Strains; Tissue Distribution | 1982 |
Some aspects of porphyrin neurotoxicity in vitro.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Heme; Male; Mice; Nerve Growth Factors; Neurons, Afferent; Porphyrins | 1982 |
Erythroblast iron metabolism in sideroblastic marrows.
Topics: Adult; Aged; Aminolevulinic Acid; Anemia, Sideroblastic; Bone Marrow; Cytoplasm; Erythroblasts; Erythrocyte Indices; Erythrocytes; Erythropoietin; Female; Ferritins; Heme; Humans; Iron; Male; Middle Aged; Mitochondria; Pyridoxal Phosphate | 1982 |
[Hemin treatment in a case of porphyria variegata].
Topics: Adult; Aminolevulinic Acid; Coproporphyrins; Female; Heme; Hemin; Humans; Liver Diseases; Porphobilinogen; Porphyrias; Uroporphyrins | 1982 |
2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated depression of rat testicular heme synthesis and microsomal cytochrome P-450.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Dioxins; Heme; Male; Microsomes; Mitochondria; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Testis | 1982 |
Mechanism of thiamine-induced respiratory deficiency in Saccharomyces carlsbergensis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Coproporphyrins; Cytochromes; Heme; Protoporphyrins; Pyridoxine; Saccharomyces; Thiamine | 1981 |
Formation and disposition of newly synthesized heme in adult rat hepatocytes in primary culture.
Topics: Aminolevulinic Acid; Animals; Bile Pigments; Cells, Cultured; Cycloheximide; Heme; Kinetics; Liver; Male; Models, Biological; Rats; Rats, Inbred Strains | 1981 |
Mitogenic and co-mitogenic properties of hemin.
Topics: Adult; Aminolevulinic Acid; Animals; Biliverdine; Cattle; Concanavalin A; Heme; Hemin; Horses; Humans; Immunity, Cellular; Lymphocyte Activation; Middle Aged; Mitogens; Protoporphyrins; Thymidine | 1981 |
Bile pigment synthesis in plants. Incorporation of haem into phycocyanobilin and phycobiliproteins in Cyanidium caldarium.
Topics: Aminolevulinic Acid; Bile Pigments; Chemical Phenomena; Chemistry; Darkness; Heme; Light; Light-Harvesting Protein Complexes; Phycobilins; Phycocyanin; Plant Proteins; Pyrroles; Rhodophyta; Spectrophotometry; Tetrapyrroles | 1981 |
Conversion of 5-aminolaevulinate into haem by liver homogenates. Comparison of rat and chick embryo.
Topics: Aminolevulinic Acid; Animals; Chick Embryo; Ferrous Compounds; Heme; In Vitro Techniques; Kinetics; Levulinic Acids; Liver; Male; Porphobilinogen; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains | 1981 |
Increased release of delta-aminolevulinic acid from protein during inhibition of protein synthesis in heart: evidence for the extensive reutilization of heme in cardiac protein metabolism.
Topics: Aminolevulinic Acid; Animals; Cycloheximide; Heart; Heme; Levulinic Acids; Mice; Myocardium; Organ Culture Techniques; Phenylalanine; Proteins; Puromycin | 1980 |
Metabolism of hepatic haem and 'green pigments' in rats given 2-allyl-2-isopropylacetamide and ferric citrate. A new model for hepatic haem turnover.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Female; Ferric Compounds; Heme; Iron; Kinetics; Liver; Models, Biological; Organ Size; Pigments, Biological; Rats | 1980 |
Synthesis of cytochrome P-450 heme in ascorbic acid-deficient guinea pigs.
Topics: Aminolevulinic Acid; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Cytochrome P-450 Enzyme System; Cytochromes; Diet; Guinea Pigs; Heme; In Vitro Techniques; Male; Microsomes, Liver; Pharmaceutical Preparations; Porphyrins; Proteins | 1980 |
Drugs and the hepatic porphyrias.
Topics: Acetamides; Aminolevulinic Acid; Animals; Barbiturates; Cats; Dicarbethoxydihydrocollidine; Dogs; Griseofulvin; Heme; Humans; Hydrocarbons, Halogenated; Hypnotics and Sedatives; Iron; Liver; Liver Diseases; Porphyrias | 1980 |
[Effect of cigarette smoking on various links in heme biosynthesis].
Topics: Adult; Aminolevulinic Acid; Coproporphyrins; Heme; Hemoglobins; Humans; Male; Middle Aged; Porphobilinogen Synthase; Protoporphyrins; Smoking | 1980 |
Biosynthetic preparation of isotopically labeled heme.
Topics: Aminolevulinic Acid; Animals; Carbon Isotopes; Cytochromes b5; Glutamic Acid; Heme; Isotope Labeling; Magnetic Resonance Spectroscopy; Rats | 1995 |
The effect of aluminum chloride on some steps of heme biosynthesis in rats after oral exposure.
Topics: 5-Aminolevulinate Synthetase; Administration, Oral; Aluminum Chloride; Aluminum Compounds; Aminolevulinic Acid; Animals; Chlorides; Female; Hematocrit; Heme; Heme Oxygenase (Decyclizing); Kidney; Liver; Porphobilinogen Synthase; Rats; Rats, Wistar | 1994 |
Heme requirement for production of active endothelial nitric oxide synthase in baculovirus-infected insect cells.
Topics: Amino Acid Oxidoreductases; Aminolevulinic Acid; Animals; Base Sequence; Cell Line; Cloning, Molecular; DNA; DNA Primers; Endothelium, Vascular; Flavins; Gene Expression; Heme; Humans; Isoniazid; Kinetics; Molecular Sequence Data; Nitric Oxide Synthase; Nitrites; Penicillamine; Polymerase Chain Reaction; Recombinant Proteins; Spodoptera; Transfection | 1995 |
Alterations in the heme biosynthetic pathway from the III-V semiconductor metal, indium arsenide (InAs).
Topics: Aminolevulinic Acid; Animals; Arsenic; Arsenicals; Cricetinae; Erythrocytes; Heme; Indium; Kidney; Liver; Male; Mesocricetus; Porphobilinogen Synthase; Porphyrins; Time Factors | 1995 |
The effect of ALA and radiation on porphyrin/heme biosynthesis in endothelial cells.
Topics: Aminolevulinic Acid; Cell Line, Transformed; Endothelium, Vascular; Heme; Humans; Porphyrins | 1995 |
High delta-aminolevulinic acid uptake in rat cerebral cortex: effect on porphyrin biosynthesis.
Topics: Aminolevulinic Acid; Animals; Cerebral Cortex; Chromatography, High Pressure Liquid; Glucose; Heme; In Vitro Techniques; Male; Porphyrins; Rats; Spectrometry, Fluorescence | 1995 |
The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA).
Topics: Aminolevulinic Acid; Cells, Cultured; Heme; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Photochemotherapy; Protoporphyrins; Receptors, Transferrin; Reference Values; Sezary Syndrome; Skin Neoplasms | 1995 |
Regulation of heme biosynthesis in Escherichia coli.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Coproporphyrinogen Oxidase; Escherichia coli; Feedback; Ferrochelatase; Gene Expression Regulation, Enzymologic; Glutamic Acid; Heme; Hydroxymethylbilane Synthase; Mice; Porphyrins; Pyrroles; Rats; Recombinant Proteins; Tetrapyrroles | 1995 |
Delta-aminolevulinate increases heme saturation and yield of human cystathionine beta-synthase expressed in Escherichia coli.
Topics: Aminolevulinic Acid; beta-Galactosidase; Cystathionine beta-Synthase; Escherichia coli; Heme; Hemeproteins; Humans; Recombinant Fusion Proteins; Spectrophotometry | 1995 |
Protoporphyrinogen accumulation in cultured hepatocytes treated with the diphenyl ether herbicide, acifluorfen.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Heme; Herbicides; Liver; Nitrobenzoates; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Phenyl Ethers; Protoporphyrinogen Oxidase; Protoporphyrins; Rats | 1994 |
A cellular stress model for the sequestration of redox-active glial iron in the aging and degenerating nervous system.
Topics: Aging; Aminolevulinic Acid; Animals; Astrocytes; Cysteamine; Glycine; Heme; Heme Oxygenase (Decyclizing); Iron; Mitochondria; Nerve Degeneration; Nervous System; Oxidation-Reduction; Porphyrins; Rats; Rats, Sprague-Dawley; Stress, Physiological | 1995 |
Cloning, sequencing, and expression of the structural genes for the cytochrome and flavoprotein subunits of p-cresol methylhydroxylase from two strains of Pseudomonas putida.
Topics: Amino Acid Sequence; Aminolevulinic Acid; Base Sequence; Cloning, Molecular; Cytochromes; Escherichia coli; Flavoproteins; Genes, Bacterial; Heme; Mixed Function Oxygenases; Molecular Sequence Data; Plasmids; Protein Conformation; Protein Sorting Signals; Pseudomonas putida; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid; Species Specificity | 1994 |
Photodynamic therapy using 5-aminolaevulinic acid for experimental pancreatic cancer--prolonged animal survival.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Cricetinae; Disease Models, Animal; Female; Heme; Injections, Intravenous; Lasers; Mesocricetus; Microscopy, Fluorescence; Neoplasm Transplantation; Pancreatic Neoplasms; Photochemotherapy; Protoporphyrins; Sensitivity and Specificity; Time Factors | 1994 |
Regulation of transferrin receptor mRNA expression. Distinct regulatory features in erythroid cells.
Topics: Aminolevulinic Acid; Animals; Cell Differentiation; Cell Line; Dimethyl Sulfoxide; Erythroid Precursor Cells; Gene Expression Regulation; Heme; Heptanoates; Iron; Iron-Regulatory Proteins; Isoniazid; Mice; Receptors, Transferrin; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic | 1994 |
Effect of porphyrin and irradiation on heme biosynthetic pathway in endothelial cells.
Topics: Aminolevulinic Acid; Edetic Acid; Endothelium, Vascular; Ferrochelatase; Heme; Humans; In Vitro Techniques; Porphyrins; Ultraviolet Rays; Umbilical Veins | 1994 |
Impaired erythroid-specific gene expression in cAMP-dependent protein kinase-deficient murine erythroleukemia cells.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Aminolevulinic Acid; Animals; Blotting, Northern; Cell Differentiation; Cell Nucleus; Ferritins; Gene Expression; Genes, myc; Globins; Hematinics; Heme; Hemin; Hemoglobins; Hydroxymethylbilane Synthase; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Oncogenes; Protein Kinases; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Increased delta aminolevulinic acid and decreased pineal melatonin production. A common event in acute porphyria studies in the rat.
Topics: Acetylserotonin O-Methyltransferase; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aminolevulinic Acid; Animals; Arylamine N-Acetyltransferase; Cells, Cultured; Enzyme Inhibitors; gamma-Aminobutyric Acid; Heme; Heptanoates; In Vitro Techniques; Isoproterenol; Male; Melatonin; Norepinephrine; Photoperiod; Pineal Gland; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Rats; Rats, Wistar; Tryptophan | 1996 |
Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability.
Topics: Aminolevulinic Acid; Animals; Arginine; Biopterins; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Heme; Homeostasis; Interferon-gamma; Iron; Isoenzymes; Kinetics; Lipopolysaccharides; Macromolecular Substances; Macrophage Activation; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Time Factors | 1996 |
Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution.
Topics: Acetamides; Aminolevulinic Acid; Animals; Base Sequence; Cell Compartmentation; Cell Differentiation; Cells, Cultured; Erythroid Precursor Cells; Ferritins; Gene Expression Regulation; Globins; Heme; Hemin; Hemoglobins; Intracellular Fluid; Iron; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Leukemia, Erythroblastic, Acute; Mice; Molecular Sequence Data; Protein Conformation; Recombinant Fusion Proteins; RNA; RNA-Binding Proteins; Transfection; Tumor Cells, Cultured | 1996 |
Inhibition of hemoglobin expression by heterologous production of nitric oxide synthase in the K562 erythroleukemic cell line.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Base Sequence; Butyrates; Butyric Acid; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Leukemic; Globins; Heme; Hemin; Hemoglobins; Humans; Iron-Sulfur Proteins; Leukemia, Erythroblastic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Sequence Data; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase; Protein Biosynthesis; Recombinant Proteins; Transfection; Tumor Cells, Cultured | 1996 |
The prooxidant effect of 5-aminolevulinic acid in the brain tissue of rats: implications in neuropsychiatric manifestations in porphyrias.
Topics: Aminolevulinic Acid; Animals; Biological Transport; Brain; Calcium; Catalase; Cerebral Cortex; Ferritins; Glutathione Peroxidase; Heme; Kinetics; Male; Nerve Tissue Proteins; Oxidants; Porphyrias; Rats; Rats, Wistar; Receptors, Cell Surface; Sulfhydryl Compounds; Synaptic Membranes; Synaptosomes | 1996 |
Expression of catalytically active barley glutamyl tRNAGlu reductase in Escherichia coli as a fusion protein with glutathione S-transferase.
Topics: Aldehyde Oxidoreductases; Amino Acid Sequence; Aminolevulinic Acid; Base Sequence; Cytochromes; Escherichia coli; Glutamates; Glutamic Acid; Glutathione Transferase; Heme; Hemin; Hordeum; Molecular Sequence Data; Oxidation-Reduction; Recombinant Fusion Proteins; Spectrophotometry | 1996 |
Stimulation of tetrapyrrole synthesis in mammalian epithelial cells in culture by exposure to aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Arginine; Biological Transport; Carbon Radioisotopes; Cattle; Cell Division; Cell Line; Cycloheximide; Dactinomycin; Epithelium; gamma-Aminobutyric Acid; Glutamic Acid; Heme; Kinetics; Leucine; Mammals; Pyrroles; Radioisotope Dilution Technique; Tetrapyrroles | 1997 |
Requirement of heme to replace the sparking sterol function in the yeast Saccharomyces cerevisiae.
Topics: Aminolevulinic Acid; Ergosterol; Heme; Saccharomyces cerevisiae; Sterols | 1997 |
The effect of L-cysteine and N-acetylcysteine on porphyrin/heme biosynthetic pathway in cells treated with 5-aminolevulinic acid and exposed to radiation.
Topics: Acetylcysteine; Aminolevulinic Acid; Cells, Cultured; Cysteine; Endothelium, Vascular; Ferrochelatase; Heme; Humans; Porphyrins; Ultraviolet Rays | 1996 |
Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Anesthetics, Inhalation; Animals; Cytochrome P-450 Enzyme System; Enflurane; Heme; Hypnotics and Sedatives; Isoflurane; Liver; Male; Mice; Phenobarbital; Porphobilinogen; Porphyrins | 1997 |
Comparison of delta-aminolaevulinic acid and its methyl ester as an inducer of porphyrin synthesis in cultured cells.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Extracellular Space; Heme; Liver; Photosensitizing Agents; Protoporphyrins; Rats; Stimulation, Chemical | 1997 |
Inhibitory effect of selenium on enzymes involved in heme biosynthetic pathway in chick embryos.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Chick Embryo; Dactinomycin; Enzyme Inhibitors; Heme; Liver; Porphobilinogen Synthase; Porphyrins; Protein Synthesis Inhibitors; Selenium; Sulfhydryl Compounds; Time Factors | 1996 |
Role of the hemA gene product and delta-aminolevulinic acid in regulation of Escherichia coli heme synthesis.
Topics: 5-Aminolevulinate Synthetase; Aldehyde Oxidoreductases; Aminolevulinic Acid; Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Heme; Molecular Chaperones; Promoter Regions, Genetic | 1997 |
Irgasan DP 300 (5-chloro-2-(2,4-dichlorophenoxy)-phenol) induces cytochrome P450s and inhibits haem biosynthesis in rat hepatocytes cultured on Matrigel.
Topics: Aminolevulinic Acid; Animals; Anti-Infective Agents, Local; Carbanilides; Cells, Cultured; Chromatography, High Pressure Liquid; Collagen; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Combinations; Enzyme Induction; Extracellular Matrix; Heme; Laminin; Liver; Male; Proteoglycans; Rats; Rats, Wistar; Uroporphyrinogen III Synthetase; Uroporphyrinogens; Uroporphyrins | 1997 |
Effects of starvation for heme on the synthesis of porphyrins in Escherichia coli.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Butanols; Escherichia coli; Gene Expression Regulation, Bacterial; Guanosine Tetraphosphate; Heme; Porphyrins; Protoporphyria, Erythropoietic | 1997 |
Haem precursor delta-aminolaevulinic acid induces activation of the cytosolic iron regulatory protein 1.
Topics: Acetylcysteine; Aminolevulinic Acid; Animals; Cell Line; Cricetinae; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Ferritins; Heme; Homeostasis; Iron; Iron Regulatory Protein 1; Iron-Regulatory Proteins; Iron-Sulfur Proteins; Lung; Oxidation-Reduction; Porphobilinogen Synthase; Reactive Oxygen Species; RNA-Binding Proteins; RNA, Messenger | 1997 |
An Escherichia coli ccm (cytochrome c maturation) deletion strain substantially expresses Hydrogenobacter thermophilus cytochrome c552 in the cytoplasm: availability of haem influences cytochrome c552 maturation.
Topics: Aminolevulinic Acid; Bacteria; Cytochrome c Group; Cytoplasm; Escherichia coli; Heme | 1998 |
Formation of zinc protoporphyrin in cultured hepatocytes: effects of ferrochelatase inhibition, iron chelation or lead.
Topics: Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Ferrochelatase; Heme; Iron Chelating Agents; Lead; Liver; Male; Protoporphyrins; Rats; Rats, Inbred F344 | 1998 |
Differentiation-specific increase in ALA-induced protoporphyrin IX accumulation in primary mouse keratinocytes.
Topics: Aminolevulinic Acid; Animals; Calcium; Cell Differentiation; Heme; Keratinocytes; Mice; Photochemotherapy; Porphobilinogen Synthase; Protoporphyrins; Rats; RNA, Messenger | 1998 |
Regulatory role of ALA-S and ALA-D in a haem-deficient mutant of Saccharomyces cerevisiae.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Ammonia-Lyases; Cell Division; Heme; Mutation; Porphobilinogen Synthase; Porphyrins; Saccharomyces cerevisiae | 1998 |
On the carcinogenic risk evaluation of diesel exhaust: benzene in airborne particles and alterations of heme metabolism in lymphocytes as markers of exposure.
Topics: Adult; Air Pollutants; Aminolevulinic Acid; Benzene; Biomarkers; Heme; Humans; Inhalation Exposure; Lymphocytes; Male; Mutagenicity Tests; Neoplasms; Occupational Exposure; Risk Assessment; Transportation; Vehicle Emissions | 1998 |
5-Aminolevulinic acid dehydratase deficiency porphyria: a twenty-year clinical and biochemical follow-up.
Topics: Adolescent; Aminolevulinic Acid; Arginine; Biomarkers; Erythrocytes; Follow-Up Studies; Glucose; Heme; Humans; Male; Mutation; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Porphyrins | 1998 |
Expression of a soybean gene encoding the tetrapyrrole-synthesis enzyme glutamyl-tRNA reductase in symbiotic root nodules.
Topics: Aldehyde Oxidoreductases; Amino Acid Sequence; Aminolevulinic Acid; Base Sequence; Chlorophyll; DNA, Complementary; DNA, Plant; Escherichia coli; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Genes, Plant; Genetic Complementation Test; Glycine max; Heme; Molecular Sequence Data; Plant Roots; Pyrroles; RNA, Messenger; RNA, Plant; Symbiosis | 1999 |
Role of heme in intracellular trafficking of thyroperoxidase and involvement of H2O2 generated at the apical surface of thyroid cells in autocatalytic covalent heme binding.
Topics: Aminolevulinic Acid; Animals; Biological Transport; Catalase; Catalysis; Cell Compartmentation; CHO Cells; Cricetinae; Heme; Humans; Hydrogen Peroxide; Iodide Peroxidase; Sodium-Potassium-Exchanging ATPase; Surface Properties; Swine; Thyroid Gland; Transferrin | 1999 |
Nonsynergic effect of ethanol and lead on heme metabolism in rats.
Topics: Aminolevulinic Acid; Animals; Central Nervous System Depressants; Drug Synergism; Erythrocytes; Ethanol; Hematocrit; Heme; Lead; Lead Poisoning; Liver; Male; Porphobilinogen Synthase; Porphyrins; Rats; Rats, Wistar | 1999 |
A missing metabolic pathway in the cattle tick Boophilus microplus.
Topics: Aminolevulinic Acid; Animals; Cattle; Chromatography, High Pressure Liquid; Female; Heme; Ovary; Rhodnius; Species Specificity; Ticks | 1999 |
Arsenite alters heme synthesis in long-term cultures of adult rat hepatocytes.
Topics: Aminolevulinic Acid; Animals; Arsenites; Cell Survival; Cells, Cultured; Cytoplasm; Enzyme Induction; Heme; Liver; Male; Rats; Rats, Wistar; Teratogens; Time Factors; Uroporphyrins | 1999 |
The diagnosis of porphyria.
Topics: Aminolevulinic Acid; Female; Genetic Techniques; Genetic Testing; Heme; Humans; Mutation; Porphobilinogen; Porphyrias; Porphyrins | 1999 |
Complete isomer-specific 1H and 13C NMR assignments of the heme resonances of rat liver outer mitochondrial membrane cytochrome b5.
Topics: Aminolevulinic Acid; Animals; Carbon Isotopes; Cytochromes b5; Heme; Intracellular Membranes; Isomerism; Isotope Labeling; Magnetic Resonance Spectroscopy; Mitochondria, Liver; Protons; Rats | 1999 |
Novel inhibitors of glutamyl-tRNA(Glu) reductase identified through cell-based screening of the heme/chlorophyll biosynthetic pathway.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Arabidopsis; Chlorophyll; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Enzyme Inhibitors; Escherichia coli; Glutamates; Heme; Hordeum; Inhibitory Concentration 50; Intramolecular Transferases; Kinetics; Mutation; Recombinant Fusion Proteins; Reproducibility of Results; RNA, Transfer, Gln; Sequence Homology, Amino Acid; Spinacia oleracea; Substrate Specificity | 1999 |
Fur-independent regulation of iron metabolism by Irr in Bradyrhizobium japonicum.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Bacterial Proteins; Base Sequence; Bradyrhizobium; Gene Expression Regulation, Bacterial; Heme; Hydro-Lyases; Iron; Molecular Sequence Data; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Repressor Proteins; RNA, Bacterial; RNA, Messenger; Signal Transduction; Transcription Factors; Transcription, Genetic | 2000 |
A study of aminolevulinic acid-induced protoporphyrin IX fluorescence kinetics in the canine oral cavity.
Topics: Aminolevulinic Acid; Animals; Dogs; Dose-Response Relationship, Drug; Face; Female; Fiber Optic Technology; Fluorescence; Gingiva; Heme; Image Processing, Computer-Assisted; Mouth; Mouth Mucosa; Photosensitizing Agents; Protoporphyrins; Random Allocation; Skin; Spectrometry, Fluorescence; Time Factors; Tongue | 2000 |
Porphyrin biosynthesis in human Barrett's oesophagus and adenocarcinoma after ingestion of 5-aminolaevulinic acid.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Barrett Esophagus; Esophageal Neoplasms; Female; Ferrochelatase; Heme; Humans; Hydroxymethylbilane Synthase; Male; Middle Aged; Photochemotherapy; Photosensitizing Agents; Porphobilinogen; Porphyrins; Protoporphyrins | 2000 |
Escherichia coli is able to produce heterologous tetraheme cytochrome c(3) when the ccm genes are co-expressed.
Topics: Aminolevulinic Acid; Binding Sites; Cytochrome c Group; Desulfovibrio vulgaris; Escherichia coli; Gene Expression Regulation, Enzymologic; Heme; Mutagenesis, Site-Directed; Mutation; Periplasm; Plasmids | 2000 |
A key role for the mitochondrial benzodiazepine receptor in cellular photosensitisation with delta-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fluorescence; Heme; Humans; Mitochondria; Photosensitizing Agents; Protoporphyrins; Rats; Receptors, GABA-A; Tumor Cells, Cultured | 2000 |
Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: studies on the haem pathway.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Ammonia-Lyases; Anesthetics, Inhalation; Animals; Cytochrome P-450 Enzyme System; Enflurane; Heme; Heme Oxygenase (Decyclizing); Hydroxymethylbilane Synthase; Imidazoles; Isoflurane; Liver; Mice; Microsomes, Liver | 2000 |
Hepatotoxicity of monobromobenzene and hexabromobenzene: effects of repeated dosage in rats.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Coproporphyrins; Female; Glutathione; Heme; Kinetics; Liver; Liver Diseases; Porphobilinogen Synthase; Rats; Uroporphyrins | 2000 |
Hereditary coproporphyria in Germany: clinical-biochemical studies in 53 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Arginine; Child; Chromatography, High Pressure Liquid; Coproporphyrinogen Oxidase; Coproporphyrins; Feces; Female; Germany; Heme; Heterozygote; Humans; Isomerism; Male; Middle Aged; Porphobilinogen; Porphyrias, Hepatic; Uroporphyrins | 2000 |
Is delta-aminolevulinic acid dehydratase rate limiting in heme biosynthesis following exposure of cells to delta-aminolevulinic acid?
Topics: Aminolevulinic Acid; Animals; Heme; Humans; Kinetics; Mice; Photosensitizing Agents; Porphobilinogen Synthase; Rats; Tumor Cells, Cultured | 2001 |
Zinc mesoporphyrin represses induced hepatic 5-aminolevulinic acid synthase and reduces heme oxygenase activity in a mouse model of acute hepatic porphyria.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Aminolevulinic Acid; Animals; Arginine; Cytosol; Drug Combinations; Female; Heme; Heme Oxygenase (Decyclizing); Injections, Intraperitoneal; Liver; Metalloporphyrins; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Phenobarbital; Porphyria, Acute Intermittent; Porphyrias, Hepatic; Reference Values; RNA, Messenger | 2001 |
Multiple regulatory steps in erythroid heme biosynthesis.
Topics: Aminolevulinic Acid; Animals; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Heme; Heptanoates; Iron; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Porphyrins; Tumor Cells, Cultured | 2000 |
Reductive and non-reductive mechanisms of iron assimilation by the yeast Saccharomyces cerevisiae.
Topics: Aminolevulinic Acid; Culture Media; Deferoxamine; Ferric Compounds; FMN Reductase; Heme; Iron; Iron Chelating Agents; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Saccharomyces cerevisiae | 1989 |
Mitochondrial ferredoxin is required for heme A synthesis in Saccharomyces cerevisiae.
Topics: Adrenodoxin; Aminolevulinic Acid; Electron Transport Complex IV; Ferredoxins; Fungal Proteins; Heme; Hydroxylation; Membrane Proteins; Mitochondria; Mutation; Plasmids; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature; Time Factors | 2002 |
Isolation and characterization of a cDNA from soybean and its homolog from Escherichia coli, which both complement the light sensitivity of Escherichia coli hemH mutant strain VS101.
Topics: Aminolevulinic Acid; Bacteriophages; DNA, Bacterial; DNA, Complementary; Escherichia coli; Ferrochelatase; Gene Deletion; Genetic Complementation Test; Glycine max; Heme; Light; Lysogeny; Mutation; Open Reading Frames; Protoporphyrins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transformation, Genetic | 2001 |
dpp genes of Rhizobium leguminosarum specify uptake of delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Antigens, Bacterial; Bacterial Proteins; Base Sequence; Biological Transport; Carrier Proteins; Dipeptides; Escherichia coli Proteins; Genes, Bacterial; Genotype; Heme; Molecular Sequence Data; Mutagenesis; Operon; Periplasmic Binding Proteins; Phylogeny; Restriction Mapping; Rhizobium leguminosarum; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Transcription, Genetic | 2002 |
Alterations of heme metabolism in lymphocytes and metal content in blood plasma as markers of diesel fuels effects on human organism.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Biomarkers; DNA; Female; Ferrochelatase; Heme; Humans; Inhalation Exposure; Lymphocytes; Male; Middle Aged; Neoplasms; Occupational Exposure; Risk Assessment; Vehicle Emissions; Volatilization; Zinc | 2002 |
Small Cab-like proteins regulating tetrapyrrole biosynthesis in the cyanobacterium Synechocystis sp. PCC 6803.
Topics: Algal Proteins; Aminolevulinic Acid; Chlorophyll; Cyanobacteria; Heme; Kinetics; Mutation; Oxygen; Photosynthesis; Protochlorophyllide; Pyrroles; Tetrapyrroles | 2002 |
A molecular, enzymatic and clinical study in a family with hereditary coproporphyria.
Topics: Adult; Aminolevulinic Acid; Arginine; Coproporphyrinogen Oxidase; DNA Mutational Analysis; Feces; Female; Heme; Humans; Porphyrias; Protein Denaturation | 2002 |
Regulation of CO production in cerebral microvessels of newborn pigs.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminolevulinic Acid; Animals; Animals, Newborn; Calcium; Calcium Signaling; Capillaries; Carbon Monoxide; Catalysis; Cerebrovascular Circulation; Cytosol; Enzyme Inhibitors; Genistein; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Ionomycin; Ionophores; Phosphorylation; Photosensitizing Agents; Swine; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 2003 |
5-Aminolevulinic acid synthesis in epimastigotes of Trypanosoma cruzi.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Ammonia-Lyases; Animals; Heme; Porphobilinogen; Rhodobacter sphaeroides; Succinate-CoA Ligases; Transaminases; Trypanosoma cruzi | 2003 |
Either soluble or plastidic expression of recombinant protoporphyrinogen oxidase modulates tetrapyrrole biosynthesis and photosynthetic efficiency in transgenic rice.
Topics: Aminolevulinic Acid; Bacillus subtilis; Blotting, Western; Carbon Dioxide; Chlorophyll; Gene Expression; Genetic Vectors; Heme; Oryza; Oxidoreductases Acting on CH-CH Group Donors; Photosynthesis; Plants, Genetically Modified; Plastids; Protoporphyrinogen Oxidase; Recombinant Proteins; RNA, Messenger; Solubility; Tetrapyrroles | 2003 |
Export of a heterologous cytochrome P450 (CYP105D1) in Escherichia coli is associated with periplasmic accumulation of uroporphyrin.
Topics: Aminolevulinic Acid; Cytochrome P-450 Enzyme System; Cytochromes b5; Cytoplasm; DNA; Dose-Response Relationship, Drug; Escherichia coli; Heme; Humans; Hydrogen-Ion Concentration; Models, Biological; Oxygen; Periplasm; Porphyrins; Spectrophotometry; Streptomyces griseus; Uroporphyrins | 2003 |
Correction of the biochemical defect in porphobilinogen deaminase deficient cells by non-viral gene delivery.
Topics: Aminolevulinic Acid; Animals; Chromatography, High Pressure Liquid; Fibroblasts; Gene Transfer Techniques; Genetic Techniques; Genetic Vectors; Heme; Humans; Hydroxymethylbilane Synthase; Mice; Photosensitizing Agents; Plasmids; Porphyria, Acute Intermittent; Protoporphyrins; Time Factors; Transfection | 2003 |
Significance of mitochondria for porphyrin and heme biosynthesis.
Topics: Aminolevulinic Acid; Glycine; Heme; Hemoglobins; Iron; Mitochondria; Porphyrins; Succinic Acid | 1959 |
[Metabolism of aminolevulinic acid and the biosynthesis of heme].
Topics: Amino Acids; Aminolevulinic Acid; Heme; Hemoglobins | 1958 |
[The influence of ionizing radiation on incorporation of 5-aminolevulinic acid and porphobilinogen into heme in vitro].
Topics: Amino Acids; Aminolevulinic Acid; Heme; In Vitro Techniques; Levulinic Acids; Porphobilinogen; Porphyrins; Proteins; Radiation Effects; Radiation, Ionizing | 1962 |
The effects of inhibition of haem biosynthesis by griseofulvin on intestinal iron absorption.
Topics: Administration, Oral; Aminolevulinic Acid; Animals; Biological Transport; Body Weight; Cation Transport Proteins; Drug Interactions; Duodenum; Gene Expression; Griseofulvin; Heme; In Vitro Techniques; Intestinal Absorption; Iron-Binding Proteins; Iron, Dietary; Liver; Male; Mice; Organ Size; Porphobilinogen | 2004 |
The source of heme for vascular heme oxygenase II: de novo heme biosynthesis in rat aorta.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Aorta; Canada; Carbon Radioisotopes; Glycine; Heme; Heme Oxygenase (Decyclizing); Male; Muscle, Smooth, Vascular; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine | 2004 |
Inactivation of Plasmodium falciparum by photodynamic excitation of heme-cycle intermediates derived from delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Animals; Culture Media; Erythrocytes; Heme; Humans; Light; Microscopy, Fluorescence; Parasitology; Photosensitizing Agents; Plasmodium falciparum | 2004 |
Functional characterization of the purified holo form of hemoglobin I from Lucina pectinata overexpressed in Escherichia coli.
Topics: Amino Acid Sequence; Amino Acid Substitution; Aminolevulinic Acid; Animals; Bivalvia; Cloning, Molecular; Escherichia coli; Heme; Hemoglobins; Hydrogen Sulfide; Molecular Sequence Data; Protein Binding; Recombinant Proteins; Sequence Alignment | 2004 |
Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase.
Topics: Aminolevulinic Acid; Biochemistry; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Histidine; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Iron; Isopropyl Thiogalactoside; Kynurenine; Plasmids; Protoporphyrins; Recombinant Proteins; Temperature; Time Factors; Tryptophan; Tryptophan Oxygenase | 2004 |
Effect of altered iron metabolism on markers of haem biosynthesis and intestinal iron absorption in mice.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Biomarkers; Duodenum; Heme; Hypoxia; Intestinal Absorption; Iron; Iron Metabolism Disorders; Liver; Male; Mice; Mice, Inbred Strains; Models, Animal; Porphobilinogen Synthase | 2005 |
Concurrent interactions of heme and FLU with Glu tRNA reductase (HEMA1), the target of metabolic feedback inhibition of tetrapyrrole biosynthesis, in dark- and light-grown Arabidopsis plants.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Arabidopsis; Arabidopsis Proteins; Darkness; Feedback, Physiological; Gene Expression Regulation, Plant; Genetic Complementation Test; Heme; Light; Mutagenesis; Photosynthesis; Recombinant Fusion Proteins; Tetrapyrroles | 2004 |
Heme-reversible impairment of CYP2B1/2 induction in heme-depleted rat hepatocytes in primary culture: translational control by a hepatic alpha-subunit of the eukaryotic initiation factor kinase?
Topics: Aminolevulinic Acid; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cytochrome P-450 CYP2B1; eIF-2 Kinase; Enzyme Induction; Heat-Shock Proteins; Heme; Hepatocytes; Molecular Chaperones; Peptide Elongation Factor 2; Phenobarbital; Phosphorylation; Proteins; Protoporphyrins; Pyrimethamine; Rats; Steroid Hydroxylases; Transcriptional Activation | 2005 |
Glutamyl-tRNA reductase of Chlorobium vibrioforme is a dissociable homodimer that contains one tightly bound heme per subunit.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Chlorobium; Dimerization; Glycerol; Heme; Molecular Sequence Data; Molecular Weight; RNA, Transfer, Amino Acyl | 2005 |
The Chlamydomonas reinhardtii gtr gene encoding the tetrapyrrole biosynthetic enzyme glutamyl-trna reductase: structure of the gene and properties of the expressed enzyme.
Topics: Absorption; Aldehyde Oxidoreductases; Algal Proteins; Amino Acid Sequence; Aminolevulinic Acid; Animals; Base Sequence; Catalysis; Chlamydomonas reinhardtii; DNA, Algal; DNA, Complementary; Enzyme Inhibitors; Escherichia coli; Esterases; Genetic Complementation Test; Heme; Hemin; Molecular Sequence Data; Molecular Weight; Mutation; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Spectrophotometry; Tetrapyrroles | 2005 |
Enzymes of the heme biosynthetic pathway in the nonphotosynthetic alga Polytomella sp.
Topics: Amino Acid Sequence; Aminolevulinic Acid; Animals; Antibodies; Base Sequence; Cell Culture Techniques; Chlamydomonas reinhardtii; DNA, Algal; DNA, Complementary; Escherichia coli; Eukaryota; Evolution, Molecular; Ferrochelatase; Gene Library; Genetic Complementation Test; Heme; Intramolecular Transferases; Molecular Sequence Data; Mutation; Oxidoreductases Acting on CH-CH Group Donors; Proteins; Sequence Analysis, DNA; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Subcellular Fractions | 2005 |
Regulation of soluble guanylyl cyclase: looking beyond NO.
Topics: Aminolevulinic Acid; Animals; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heme; Humans; Nitric Oxide; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2006 |
Phototherapy and malignancy: possible enhancement by iron administration and hyperbaric oxygen.
Topics: Aminolevulinic Acid; Combined Modality Therapy; Heme; Heme Oxygenase-1; Humans; Hyperbaric Oxygenation; Iron; Mitochondria; Neoplasms; Oxidation-Reduction; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species | 2006 |
Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation.
Topics: Aminolevulinic Acid; Animals; Cattle; Deferoxamine; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heme; Iron; Models, Biological; Organ Culture Techniques; Oxidation-Reduction; Photosensitizing Agents; Protoporphyrins; Pulmonary Artery; Receptors, Cytoplasmic and Nuclear; Serotonin; Soluble Guanylyl Cyclase; Vasodilation | 2006 |
The housekeeping dipeptide permease is the Escherichia coli heme transporter and functions with two optional peptide binding proteins.
Topics: Aminolevulinic Acid; Bacterial Proteins; Biological Transport; DNA Transposable Elements; Escherichia coli; Escherichia coli Proteins; Heme; Iron; Membrane Transport Proteins; Mutation; Peptides; Protein Binding | 2006 |
Impact of two novel mutations on the structure and function of human myeloperoxidase.
Topics: Aminolevulinic Acid; Arginine; Calnexin; Calreticulin; Endoplasmic Reticulum; Glycine; Heme; Humans; K562 Cells; Kidney; Models, Molecular; Mutation, Missense; Oxygen; Peroxidase; Peroxidases | 2007 |
Silencing of human ferrochelatase causes abundant protoporphyrin-IX accumulation in colon cancer.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Colonic Neoplasms; Ferrochelatase; Gene Expression Regulation, Enzymologic; Heme; Heme Oxygenase (Decyclizing); Humans; Protoporphyrins; RNA, Messenger; RNA, Small Interfering; Stomach Neoplasms | 2008 |
Intermittent unexplained abdominal pain: is it porphyria?
Topics: Abdominal Pain; Acute Disease; Adult; Aminolevulinic Acid; Anti-Infective Agents; Cimetidine; Contraceptives, Oral; Diet, Reducing; Enzyme Inhibitors; Female; Heme; Hemin; Humans; Liver; Liver Transplantation; Porphobilinogen; Porphyrias, Hepatic; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections | 2007 |
Essential role of the AH receptor in the dysfunction of heme metabolism induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A2; Disease Models, Animal; Environmental Pollutants; Female; Gene Expression; Gene Expression Profiling; Gene Silencing; Heme; Iron Overload; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Oxidative Stress; Polychlorinated Dibenzodioxins; Porphyria Cutanea Tarda; Receptors, Aryl Hydrocarbon; Up-Regulation; Uroporphyrins | 2008 |
Leishmania spp.: delta-aminolevulinate-inducible neogenesis of porphyria by genetic complementation of incomplete heme biosynthesis pathway.
Topics: Aminolevulinic Acid; Animals; Blotting, Western; Chromatography, Thin Layer; DNA, Complementary; Heme; Hydroxymethylbilane Synthase; Leishmania; Porphobilinogen Synthase; Porphyrins; Spectrometry, Fluorescence; Transfection; Transgenes; Uroporphyrins | 2008 |
Functional differences between heme permeases: Serratia marcescens HemTUV permease exhibits a narrower substrate specificity (restricted to heme) than the Escherichia coli DppABCDF peptide-heme permease.
Topics: Aminolevulinic Acid; Bacterial Proteins; Biological Transport; Dipeptides; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Heme; Iron; Luminescence; Membrane Transport Proteins; Protein Binding; Serratia marcescens; Substrate Specificity | 2008 |
Functional characterization of human duodenal cytochrome b (Cybrd1): Redox properties in relation to iron and ascorbate metabolism.
Topics: Aminolevulinic Acid; Animals; Ascorbic Acid; Baculoviridae; Cell Line; Cloning, Molecular; Cytochrome b Group; Duodenum; Electron Spin Resonance Spectroscopy; Ferricyanides; Genetic Vectors; Heme; Histidine; Humans; Iron; Ligands; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases; Potentiometry; Recombinant Proteins; Transduction, Genetic | 2008 |
The effect of haem biosynthesis inhibitors and inducers on intestinal iron absorption and liver haem biosynthetic enzyme activities.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Antimicrobial Cationic Peptides; Duodenum; Enzyme Inhibitors; Heme; Hepcidins; Heptanoates; Intestinal Absorption; Iron Compounds; Male; Mice; Porphobilinogen; Porphobilinogen Synthase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Lead poisoning from the beauty case: neurologic manifestations in an elderly woman.
Topics: Aged; Aminolevulinic Acid; Anemia, Macrocytic; Causality; Diagnostic Errors; Erythrocytes; Female; Heme; Humans; Lead Poisoning, Nervous System, Adult; Peripheral Nerves; Peripheral Nervous System Diseases; Porphyrins; Protoporphyria, Erythropoietic; Protoporphyrins | 2008 |
The heme precursor delta-aminolevulinate blocks peripheral myelin formation.
Topics: Aminolevulinic Acid; Animals; Axons; Cells, Cultured; Coculture Techniques; Dichloroacetic Acid; Dose-Response Relationship, Drug; Free Radicals; Ganglia, Spinal; Heme; Mice; Myelin Proteins; Myelin Sheath; Nerve Fibers, Myelinated; Neurons, Afferent; Neurotoxins; Oxidative Stress; Peripheral Nerves; Peripheral Nervous System Diseases; Rats; Schwann Cells | 2008 |
Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation.
Topics: Aminolevulinic Acid; Antineoplastic Agents; Apoptosis; Butyric Acid; Cell Proliferation; Drug Screening Assays, Antitumor; Heme; Histones; HL-60 Cells; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Phosphorylation; Photochemistry; Porphyrins; Prodrugs; Proteasome Inhibitors; Proto-Oncogene Proteins c-myc; Reactive Oxygen Species; Stereoisomerism; Tumor Cells, Cultured | 2008 |
High-level production of recombinant Arenicola marina globin chains in Escherichia coli: a new generation of blood substitute.
Topics: Adult; Amino Acid Sequence; Aminolevulinic Acid; Animals; Blood Substitutes; Escherichia coli; Genetic Engineering; Globins; Heme; Hemoglobins; Humans; Mass Spectrometry; Molecular Sequence Data; Oxidation-Reduction; Polychaeta; Recombinant Fusion Proteins; Solubility; Spectrophotometry, Ultraviolet | 2009 |
Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats.
Topics: Aminolevulinic Acid; Animals; Brain; Brain Chemistry; Catalase; Flavonoids; Glutathione; Glutathione Disulfide; Heme; Lead; Lead Poisoning; Male; Oxidative Stress; Porphobilinogen Synthase; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2010 |
Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target.
Topics: Aminolevulinic Acid; Anti-Infective Agents; Antineoplastic Agents; Artemisinins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Evaluation, Preclinical; Heme; Humans; Iron; Models, Chemical; Protoporphyrins; Spectrophotometry; Transferrin | 2009 |
Lack of hemodynamic effects after extended heme synthesis inhibition by succinylacetone in rats.
Topics: Aminolevulinic Acid; Animals; Blood Pressure; Guanylate Cyclase; Heme; Hemodynamics; Heptanoates; Hypertension; Kidney; Male; Nitric Oxide Synthase; Organ Specificity; Porphobilinogen Synthase; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sodium; Soluble Guanylyl Cyclase | 2010 |
Light-induced cytotoxicity after aminolevulinic acid treatment is mediated by heme and not by iron.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Deferoxamine; Heme; Heme Oxygenase-1; Humans; Iron; Iron Chelating Agents; Light; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species | 2010 |
Rapid dark repression of 5-aminolevulinic acid synthesis in green barley leaves.
Topics: Aminolevulinic Acid; Darkness; Heme; Hordeum; Lipid Peroxidation; Nitrobenzoates; Oxidoreductases Acting on CH-CH Group Donors; Photosynthesis; Plant Leaves; Protochlorophyllide; Protoporphyrinogen Oxidase; RNA, Plant | 2010 |
Measurements of heme levels and respiration rate in Salmonella enterica serovar typhimurium.
Topics: Aminolevulinic Acid; Drug Resistance, Bacterial; Heme; Salmonella typhimurium | 2010 |
Ferritin does not donate its iron for haem synthesis in macrophages.
Topics: Aminolevulinic Acid; Animals; Blotting, Western; Cell Line; Female; Ferritins; Heme; Heme Oxygenase (Decyclizing); Homeostasis; Immunoprecipitation; Iron; Macrophages; Mice | 2010 |
Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry.
Topics: Aminolevulinic Acid; Deuterium; Erythrocytes; Heme; Humans; Kinetics; Porphobilinogen; Porphobilinogen Synthase; Porphyrias; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy.
Topics: Aminolevulinic Acid; Heme; Humans; Molecular Structure; Neoplasms; Photochemotherapy; Photosensitizing Agents | 2011 |
Co-administration of meso 2,3-dimercaptosuccinic acid monoesters reduces arsenic concentration and oxidative stress in gallium arsenide exposed rats.
Topics: Aminolevulinic Acid; Animals; Arsenic; Arsenic Poisoning; Arsenicals; Catalase; Copper; Gallium; Glutathione; Heme; Kidney; Lipid Peroxidation; Liver; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Succimer; Superoxide Dismutase; Transaminases; Zinc | 2011 |
Isotopic labeling of the heme cofactor in cytochrome P450 and other heme proteins.
Topics: Aminolevulinic Acid; Animals; Carbon Isotopes; Cytochrome P-450 Enzyme System; Escherichia coli; Heme; Isotope Labeling; Nitrogen Isotopes; Protein Isoforms; Rats; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cattle; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Space; Ferrochelatase; Gene Expression Regulation; Gene Knockdown Techniques; Heme; Humans; Indoles; Neoplasm Proteins; Nitroso Compounds; Protoporphyrins; Serum; Serum Albumin, Bovine | 2011 |
Methods for analysis of photosynthetic pigments and steady-state levels of intermediates of tetrapyrrole biosynthesis.
Topics: Aminolevulinic Acid; Apoenzymes; Arabidopsis; Calibration; Carotenoids; Chemistry Techniques, Analytical; Chlorophyllides; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Heme; Horseradish Peroxidase; Photosynthesis; Pigments, Biological; Porphobilinogen; Protochlorophyllide; Spectrometry, Fluorescence; Tetrapyrroles | 2011 |
An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts.
Topics: Agrobacterium tumefaciens; Aldehyde Oxidoreductases; Amino Acid Sequence; Aminolevulinic Acid; Arabidopsis; Arabidopsis Proteins; Carrier Proteins; Chlorophyll; Chloroplasts; Escherichia coli; Gene Expression Regulation, Plant; Genes, Plant; Heme; Molecular Sequence Data; Nicotiana; Plants, Genetically Modified; Plasmids; Protein Interaction Mapping; Recombinant Proteins; RNA Interference; RNA, Plant; Thylakoid Membrane Proteins; Transcription, Genetic; Two-Hybrid System Techniques | 2011 |
Renal failure affects the enzymatic activities of the three first steps in hepatic heme biosynthesis in the acute intermittent porphyria mouse.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Enzyme Activation; Female; Heme; Hydroxymethylbilane Synthase; Kidney Function Tests; Liver; Male; Mice; Mice, Inbred C57BL; Nephrectomy; Porphyria, Acute Intermittent; Porphyrinogens; Porphyrins; Renal Insufficiency; Sex Factors | 2012 |
Evaluation of unbound free heme in plant cells by differential acetone extraction.
Topics: Acetone; Acids; Aminolevulinic Acid; Animals; Arabidopsis; Arabidopsis Proteins; Cell Nucleus; Chemical Fractionation; Chloroplasts; Heme; Hemeproteins; Hemoglobins; Myoglobin; Oxidation-Reduction; Plant Cells; Pyridazines; Sensitivity and Specificity; Serum Albumin, Bovine; Solubility | 2012 |
A multifunctional 5-aminolevulinic acid derivative induces erythroid differentiation of K562 human erythroleukemic cells.
Topics: alpha-Globins; Aminolevulinic Acid; Butyric Acid; Cell Differentiation; Cell Proliferation; Erythroid Cells; Erythropoiesis; Erythropoietin; Ferrochelatase; Glycophorins; Heme; Hemoglobins; Humans; Hydrolysis; Hydroxymethylbilane Synthase; K562 Cells; Leukemia, Erythroblastic, Acute; Levulinic Acids; Prodrugs; RNA, Messenger | 2012 |
[The laboratory diagnostics of disorders of porphyrin metabolism: a lecture].
Topics: Aminolevulinic Acid; Heme; Humans; Porphyrias; Porphyrins | 2012 |
Low-dose arsenic trioxide enhances 5-aminolevulinic acid-induced PpIX accumulation and efficacy of photodynamic therapy in human glioma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Glioma; Heme; Humans; Intracellular Space; Oxides; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Rats; Rats, Wistar | 2013 |
Constitutive expression of RyhB regulates the heme biosynthesis pathway and increases the 5-aminolevulinic acid accumulation in Escherichia coli.
Topics: 2,2'-Dipyridyl; Aminolevulinic Acid; Escherichia coli; Heme; Iron; Ribosome Subunits, Small, Bacterial; Transcription, Genetic | 2014 |
Effect of hypoxia on porphyrin metabolism in bone marrow mesenchymal stem cells.
Topics: Aminolevulinic Acid; Animals; Animals, Outbred Strains; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bone Marrow Cells; Cell Hypoxia; Cells, Cultured; Gene Expression; Heme; Indoles; Ion Transport; Iron; Mesenchymal Stem Cells; Oxygen; Porphyrins; Rats; Receptors, Transferrin | 2014 |
Dietary iron controls circadian hepatic glucose metabolism through heme synthesis.
Topics: Acetylcysteine; Aminolevulinic Acid; Animals; Antioxidants; Circadian Rhythm; Gluconeogenesis; Glucose; Heme; Hep G2 Cells; Humans; Iron, Dietary; Liver; Male; Mice; Mice, Inbred C57BL; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Reactive Oxygen Species; Transcription Factors | 2015 |
Reduced heme levels underlie the exponential growth defect of the Shewanella oneidensis hfq mutant.
Topics: Aminolevulinic Acid; Heme; Host Factor 1 Protein; Mutation; Shewanella | 2014 |
Cutaneous mitochondrial respirometry: non-invasive monitoring of mitochondrial function.
Topics: Aminolevulinic Acid; Animals; Blood Gas Monitoring, Transcutaneous; Endotoxemia; Equipment Design; Healthy Volunteers; Heme; Humans; Lipopolysaccharides; Male; Mitochondria; Monitoring, Physiologic; Oxygen; Oxygen Consumption; Protoporphyrins; Rats; Rats, Wistar; Skin | 2015 |
Role of delta-aminolevulinic acid in the symptoms of acute porphyria.
Topics: Abdominal Pain; Adult; Aminolevulinic Acid; Chelation Therapy; Diagnosis, Differential; Female; Heme; Humans; Lead Poisoning; Medicine, Ayurvedic; Neuralgia; Porphyria, Acute Intermittent; Treatment Outcome; Tyrosinemias | 2015 |
Effect of 5-aminolevulinic acid on erythropoiesis: a preclinical in vitro characterization for the treatment of congenital sideroblastic anemia.
Topics: 5-Aminolevulinate Synthetase; Amino Acid Transport Systems; Aminolevulinic Acid; Anemia, Sideroblastic; Animals; Drug Evaluation, Preclinical; Erythroblasts; Erythropoiesis; gamma-Aminobutyric Acid; Gene Knockdown Techniques; Genetic Diseases, X-Linked; Heme; Heme Oxygenase-1; Hemoglobin A; Hemoglobins, Abnormal; Humans; Induced Pluripotent Stem Cells; K562 Cells; Mice; Symporters; Up-Regulation | 2014 |
Heme biosynthesis modulation via δ-aminolevulinic acid administration attenuates chronic hypoxia-induced pulmonary hypertension.
Topics: Aminolevulinic Acid; Animals; Endothelin-1; Ferrochelatase; Heme; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Male; Mice, Inbred C57BL; MicroRNAs; Mitochondria; Pulmonary Artery; Superoxide Dismutase; Superoxides | 2015 |
Optimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli.
Topics: Aminolevulinic Acid; Biosynthetic Pathways; Cloning, Molecular; Enzyme Repression; Escherichia coli; Escherichia coli Proteins; Ferrochelatase; Gene Expression Regulation, Bacterial; Heme; Porphobilinogen Synthase; Protoporphyrinogen Oxidase; Protoporphyrins; Up-Regulation | 2015 |
The effect of iron ion on the specificity of photodynamic therapy with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Cation Transport Proteins; Cell Line, Tumor; Heme; Humans; Iron; MCF-7 Cells; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Sensitivity and Specificity | 2015 |
Heme precursor injection is effective for Arthromyces ramosus peroxidase fusion protein production by a silkworm expression system.
Topics: Agaricales; Aminolevulinic Acid; Animals; Biocatalysis; Bombyx; Gene Expression; Heme; Larva; Peroxidases; Protein Structure, Tertiary; Recombinant Fusion Proteins | 2015 |
Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis.
Topics: 5-Aminolevulinate Synthetase; Amino Acid Sequence; Aminolevulinic Acid; Animals; Biological Evolution; Endopeptidase Clp; Erythropoiesis; Eukaryota; Heme; Humans; Mitochondria; Mitochondrial Proteins; Molecular Chaperones; Molecular Sequence Data; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Zebrafish | 2015 |
Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy.
Topics: Aminolevulinic Acid; Caco-2 Cells; Cell Line, Tumor; Heme; Humans; K562 Cells; Kinetics; MCF-7 Cells; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; U937 Cells | 2015 |
Liver Transplantation for Acute Intermittent Porphyria: Biochemical and Pathologic Studies of the Explanted Liver.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Female; Heme; Humans; Hydroxymethylbilane Synthase; Liver; Liver Transplantation; Porphobilinogen; Porphyria, Acute Intermittent; RNA, Messenger; Uroporphyrins | 2015 |
Deconvoluting heme biosynthesis to target blood-stage malaria parasites.
Topics: Aminolevulinic Acid; Artemisinins; Biosynthetic Pathways; Erythrocytes; Heme; Humans; Lactones; Photosensitizing Agents; Plasmodium falciparum; Protoporphyrins; Reactive Oxygen Species | 2015 |
The Effect of 5-Aminolevulinic Acid on Cytochrome P450-Mediated Prodrug Activation.
Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cholic Acid; Cytochrome P-450 CYP2A6; Heme; Humans; Neoplasm Proteins; Prodrugs; Tegafur | 2015 |
Measurement of Heme Synthesis Levels in Mammalian Cells.
Topics: Aminolevulinic Acid; Animals; Carbon Radioisotopes; Cell Line; Cell Line, Tumor; HeLa Cells; Heme; Humans; Lung; Lung Neoplasms | 2015 |
Mitochondrial Translocator Protein (TSPO) Function Is Not Essential for Heme Biosynthesis.
Topics: Aminolevulinic Acid; Animals; Cell Death; Heme; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Mitochondria; Protoporphyrins; Receptors, GABA | 2016 |
Integrated Optimization of the In Vivo Heme Biosynthesis Pathway and the In Vitro Iron Concentration for 5-Aminolevulinate Production.
Topics: Aminolevulinic Acid; Fermentation; Heme; In Vitro Techniques; Spectrophotometry, Ultraviolet | 2016 |
Pleiotropic effects of 5-aminolevulinic acid in mouse brain.
Topics: Acetylcholinesterase; Aminolevulinic Acid; Animals; Antioxidants; Brain; Heme; Male; Mice; Nitric Oxide Synthase; Oxidative Stress; Photosensitizing Agents | 2016 |
Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Deferoxamine; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Female; Heme; Humans; Lasers, Semiconductor; Lighting; Mice; Mice, Nude; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Random Allocation; Siderophores; Skin Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Transcriptomic analysis for elucidating the physiological effects of 5-aminolevulinic acid accumulation on Corynebacterium glutamicum.
Topics: Aminolevulinic Acid; Corynebacterium glutamicum; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Glucose; Heme; Metabolic Networks and Pathways; Transcriptome | 2016 |
Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite.
Topics: Aminolevulinic Acid; Anti-Bacterial Agents; Biosynthetic Pathways; Drug Resistance, Bacterial; Escherichia coli; Genome, Bacterial; Heme; Iron Deficiencies; Metalloids; Microbial Sensitivity Tests; Models, Biological; Mutation; Protoporphyrins; Superoxides; Tellurium | 2017 |
How to Increase Brightness of Near-Infrared Fluorescent Proteins in Mammalian Cells.
Topics: Aminolevulinic Acid; Animals; Cell Line; Heme; Heme Oxygenase-1; Humans; Infrared Rays; Luminescence; Luminescent Proteins | 2017 |
The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms.
Topics: Aminolevulinic Acid; Animals; Cell Proliferation; Circadian Rhythm; Circadian Rhythm Signaling Peptides and Proteins; CLOCK Proteins; Gene Expression Regulation; Gene Knockout Techniques; Heme; Mice; NIH 3T3 Cells; RNA, Messenger | 2017 |
Role of two 5-aminolevulinic acid biosynthetic pathways in heme and secondary metabolite biosynthesis in Amycolatopsis orientalis.
Topics: 5-Aminolevulinate Synthetase; Actinobacteria; Aldehyde Oxidoreductases; Aminolevulinic Acid; Biosynthetic Pathways; Gene Knockout Techniques; Genetic Complementation Test; Heme | 2018 |
Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme.
Topics: 5-Aminolevulinate Synthetase; Amino Acid Motifs; Amino Acid Substitution; Aminolevulinic Acid; Catalytic Domain; Cloning, Molecular; Coenzymes; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Heme; Kinetics; Mitochondria; Models, Molecular; Mutation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protein Multimerization; Protein Subunits; Pyridoxal Phosphate; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity | 2018 |
Effects of 5-Aminolevulinic Acid on Gene Expression, Immunity, and ATP Levels in Pacific White Shrimp, Litopenaeus vannamei.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Animals; Catalase; Ferrochelatase; Heme; Heme Oxygenase-1; Immunity; Penaeidae; Porphobilinogen Synthase | 2018 |
Peanut genes encoding tetrapyrrole biosynthetic enzymes, AhHEMA1 and AhFC1, alleviating the salt stress in transgenic tobacco.
Topics: Aminolevulinic Acid; Arachis; Cell Membrane; Chlorophyll; Chloroplasts; Enzymes; Gene Expression Regulation, Plant; Germination; Heme; Nicotiana; Plant Proteins; Plants, Genetically Modified; Reactive Oxygen Species; Salt Stress; Seedlings; Tetrapyrroles | 2019 |
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Oxygen; Photosensitivity Disorders; Photosensitizing Agents; Porphyrias; Porphyrins; Protein Aggregates; Protein Conformation; Protoporphyrins | 2019 |
The GluTR-binding protein is the heme-binding factor for feedback control of glutamyl-tRNA reductase.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Arabidopsis; Arabidopsis Proteins; Carrier Proteins; Enzyme Stability; Feedback, Physiological; Heme; Metabolome; Mutation; Protein Binding; Proteolysis | 2019 |
Mechanistic study of PpIX accumulation using the JFCR39 cell panel revealed a role for dynamin 2-mediated exocytosis.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Dynamin II; Exocytosis; Heme; Humans; Microscopy, Fluorescence; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Trimethyl Ammonium Compounds; Ultraviolet Rays | 2019 |
Effects of 5-aminolevulinic acid and sodium ferrous citrate on fibroblasts from individuals with mitochondrial diseases.
Topics: Adenosine Triphosphate; Aminolevulinic Acid; Biosynthetic Pathways; Case-Control Studies; Citric Acid; DNA Copy Number Variations; DNA, Mitochondrial; Female; Ferrous Compounds; Fibroblasts; Heme; Heme Oxygenase-1; Humans; In Vitro Techniques; Infant; Infant, Newborn; Male; Mitochondrial Diseases; Oxidative Phosphorylation; Oxygen Consumption; RNA, Messenger; Sodium Citrate; Up-Regulation | 2019 |
δ-Aminolevulinate induces fetal hemoglobin expression by enhancing cellular heme biosynthesis.
Topics: Aminolevulinic Acid; Biosynthetic Pathways; Cell Line; Erythroid Precursor Cells; Fetal Hemoglobin; gamma-Globins; Gene Expression Regulation; Heme; Humans; Models, Biological; NF-E2-Related Factor 2; Promoter Regions, Genetic; Protein Binding; Reactive Oxygen Species | 2019 |
Probing Hexaminolevulinate Mediated PpIX Fluorescence in Cancer Cell Suspensions in the Presence of Chemical Adjuvants.
Topics: Aminolevulinic Acid; Biosynthetic Pathways; Cell Line, Tumor; Fluorescence; Heme; Humans; Molecular Imaging; Photosensitizing Agents; Protoporphyrins | 2020 |
Sars-Cov-2 interference in HEME production: is it the time for an early predictive biomarker?
Topics: Aminolevulinic Acid; Betacoronavirus; Biomarkers; Coronavirus Infections; COVID-19; Heme; Host-Pathogen Interactions; Humans; Interleukin-6; Pandemics; Pneumonia, Viral; Porphobilinogen; SARS-CoV-2; Thrombosis; Viral Proteins | 2020 |
Metabolic engineering of an auto-regulated Corynebacterium glutamicum chassis for biosynthesis of 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Corynebacterium glutamicum; Heme; Metabolic Engineering; Plasmids | 2020 |
Modulation of aminolevulinic acid-based photoinactivation efficacy by iron in vitro is cell type dependent.
Topics: Aminolevulinic Acid; Cell Line; Culture Media; Heme; Humans; Iron; Mitochondria; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Spectrometry, Fluorescence | 2020 |
Nutritional Factors That Affect the Formation of 5-Aminolevulinic Acid, a Key Intermediate of Heme Biosynthesis.
Topics: Amino Acids; Aminolevulinic Acid; Animals; Glycine; Heme; Mice; Porphyrins; Rats | 2021 |
5-Aminolevulinic acid level and dye-decolorizing peroxidase expression regulate heme synthesis in Escherichia coli.
Topics: Aldehyde Oxidoreductases; Aminolevulinic Acid; Bacterial Outer Membrane Proteins; Escherichia coli; Escherichia coli Proteins; Heme; Peroxidases | 2022 |
Therapeutic potential of 5-aminolevulinic acid and sodium-ferrous citrate for viral insults: relevance to the COVID-19 crisis.
Topics: Aminolevulinic Acid; Animals; Citric Acid; COVID-19 Drug Treatment; Ferrous Compounds; Heme; Heme Oxygenase-1; Humans; SARS-CoV-2; Sodium; Zika Virus; Zika Virus Infection | 2022 |
Analysis of corticosteroid and antiepileptic drug treatment effects on heme biosynthesis mRNA expression in lower-grade gliomas: Potential implications for 5-ALA metabolization.
Topics: Adrenal Cortex Hormones; Aminolevulinic Acid; Anticonvulsants; Brain Neoplasms; Flavoproteins; Glioma; Heme; Humans; Mitochondrial Proteins; Photochemotherapy; Protoporphyrinogen Oxidase; RNA, Messenger | 2022 |
Mechanistic modelling of enzyme-restoration effects of new recombinant liver-targeted proteins in acute intermittent porphyria.
Topics: Aminolevulinic Acid; Animals; Disease Models, Animal; Heme; Mice; Mice, Inbred C57BL; Porphyria, Acute Intermittent; Recombinant Proteins | 2022 |
Uterus-specific transcriptional regulation underlies eggshell pigment production in Japanese quail.
Topics: Aminolevulinic Acid; Animals; Coturnix; Egg Shell; Eggs; Female; Heme; Quail; Rabbits; Uterus | 2022 |
Mechanisms of Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer.
Topics: Aminolevulinic Acid; Female; Heme; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Vulvar Neoplasms | 2022 |
An Intracellular Self-Assembly-Driven Uninterrupted ROS Generator Augments 5-Aminolevulinic-Acid-Based Tumor Therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Heme; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Reactive Oxygen Species | 2022 |
Modulation and proteomic changes on the heme pathway following treatment with 5-aminolevulinic acid.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Heme; Humans; Photochemotherapy; Photosensitizing Agents; Proteomics; Protoporphyrins | 2022 |
Heme is involved in the exogenous ALA-promoted growth and antioxidant defense system of cucumber seedlings under salt stress.
Topics: Aminolevulinic Acid; Antioxidants; Cucumis sativus; Heme; Plant Leaves; Salt Stress; Salt Tolerance; Seedlings; Sodium Chloride; Stress, Physiological | 2022 |
Analysis of Renal Cell Carcinoma Cell Response to the Enhancement of 5-aminolevulinic Acid-mediated Protoporphyrin IX Fluorescence by Iron Chelator Deferoxamine
Topics: Aminolevulinic Acid; Carcinoma, Renal Cell; Cell Line, Tumor; Deferoxamine; Fluorescence; Heme; Humans; Iron; Iron Chelating Agents; Kidney Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2023 |
Effects of Supplemental Drugs on Hexaminolevulinate (HAL)-Induced PpIX Fluorescence in Bladder Cancer Cell Suspensions.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Fluorescence; Heme; Humans; Pharmaceutical Preparations; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; RNA, Messenger; Urinary Bladder Neoplasms | 2022 |
Enhancement of the cytotoxic effect of dihydroartemisinin in high-risk human papillomavirus-infected cells by aminolevulinic acid via the Bax/Bcl-2-caspase pathway.
Topics: Aminolevulinic Acid; Apoptosis; Caspases; Cell Line, Tumor; HeLa Cells; Heme; Human Papillomavirus Viruses; Humans; Papillomavirus Infections; Photochemotherapy; Reactive Oxygen Species | 2022 |
The effect of 5-aminolevulinic acid on canine peripheral blood mononuclear cells.
Topics: Aminolevulinic Acid; Animals; Dog Diseases; Dogs; Heme; Humans; Inflammation; Leukocytes, Mononuclear; Signal Transduction | 2022 |
5‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis.
Topics: Aminolevulinic Acid; Animals; Cell Proliferation; Ferritins; Ferrochelatase; Heme; Iron; Mice; Proliferating Cell Nuclear Antigen; RNA, Small Interfering; Urinary Bladder; Urinary Bladder Neoplasms | 2022 |
Construction of 5-aminolevulinic acid synthase variants by cysteine-targeted mutation to release heme inhibition.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; COVID-19; Cysteine; Heme; Hemin; Humans; Mutation | 2022 |
PLGA-PVA-PEG Single Emulsion Method as a Candidate for Aminolevulinic Acid (5-ALA) Encapsulation: Laboratory Scaling Up and Stability Evaluation.
Topics: Aminolevulinic Acid; Chlorophyll; Emulsions; Heme; Lactic Acid; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polyvinyl Alcohol; Surface-Active Agents; Tetrapyrroles | 2022 |
Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure.
Topics: Acyl Coenzyme A; Adenosine Diphosphate; Aminolevulinic Acid; Energy Metabolism; Glutamates; Heart Failure; Heme; Humans; Ketoglutaric Acids; Myocardial Infarction; Oxidative Phosphorylation | 2022 |
Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene.
Topics: Aminolevulinic Acid; Cell Line; CRISPR-Cas Systems; Heme; Humans; Oxidoreductases; Porphyria, Variegate; Protoporphyrinogen Oxidase; Protoporphyrins | 2022 |
Doxorubicin causes ferroptosis and cardiotoxicity by intercalating into mitochondrial DNA and disrupting Alas1-dependent heme synthesis.
Topics: Aminolevulinic Acid; Animals; Cardiotoxicity; DNA, Mitochondrial; Doxorubicin; Ferroptosis; Heme; Iron; Iron Overload; Mice; Mitochondria; Myocytes, Cardiac | 2022 |
A Thiosemicarbazone Derivative as a Booster in Photodynamic Therapy-A Way to Improve the Therapeutic Effect.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Heme; Humans; Iron; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Thiosemicarbazones | 2022 |
A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors.
Topics: Aminolevulinic Acid; Antimalarials; Artemisinins; Brain Neoplasms; Heme; Humans | 2023 |
Function of ALA Content in Porphyrin Metabolism Regulation of
Topics: Aminolevulinic Acid; Ananas; Chlorophyll; Heme; Porphyrins | 2023 |
RNA interference therapy in acute hepatic porphyrias.
Topics: Aminolevulinic Acid; Heme; Humans; Pain; Porphyrias; Porphyrias, Hepatic; Quality of Life; RNA Interference | 2023 |
5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells.
Topics: Aminolevulinic Acid; Caco-2 Cells; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Heme; Humans | 2023 |
Alleviation of arsenic toxicity in pepper plants by aminolevulinic acid and heme through modulating its sequestration and distribution within cell organelles.
Topics: Aminolevulinic Acid; Antioxidants; Arsenic; Chlorophyll; Glutathione; Heme; Hydrogen Peroxide; Organelles; Oxidative Stress; Phytochelatins; Seedlings | 2023 |
FC2 stabilizes POR and suppresses ALA formation in the tetrapyrrole biosynthesis pathway.
Topics: Aminolevulinic Acid; Arabidopsis; Arabidopsis Proteins; Chlorophyll; Ferrochelatase; Heme; Protochlorophyllide; Tetrapyrroles | 2023 |
A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin.
Topics: Aminolevulinic Acid; Animals; Cell Death; Heme; Mammals; Peroxiredoxins; Proteomics | 2023 |
Active Estrogen-Succinate Metabolism Promotes Heme Accumulation and Increases the Proliferative and Invasive Potential of Endometrial Cancer Cells.
Topics: Aminolevulinic Acid; Endometrial Neoplasms; Estrogens; Female; Heme; Humans; Receptors, Estrogen; Succinic Acid | 2023 |
Unleashing the potential of 5-Aminolevulinic acid: Unveiling a promising target for cancer diagnosis and treatment beyond photodynamic therapy.
Topics: Aminolevulinic Acid; Cell Line, Tumor; Heme; Humans; Male; Neoplasms; Photochemotherapy; Photosensitizing Agents; Protoporphyrins | 2023 |
Her2 oncogene transformation enhances 5-aminolevulinic acid-mediated protoporphyrin IX production and photodynamic therapy response.
Topics: Aminolevulinic Acid; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cell Transformation, Neoplastic; Epithelial-Mesenchymal Transition; Female; Heme; Humans; Levulinic Acids; Microscopy, Confocal; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Receptor, ErbB-2; Signal Transduction | 2016 |
Stable and Efficient Biosynthesis of 5-Aminolevulinic Acid Using Plasmid-Free Escherichia coli.
Topics: Aminolevulinic Acid; Biosynthetic Pathways; Escherichia coli; Heme; Levulinic Acids; Metabolic Engineering; Plasmids | 2019 |