Page last updated: 2024-08-23

heme and allylisopropylacetamide

heme has been researched along with allylisopropylacetamide in 107 studies

Research

Studies (107)

TimeframeStudies, this research(%)All Research%
pre-199092 (85.98)18.7374
1990's10 (9.35)18.2507
2000's4 (3.74)29.6817
2010's1 (0.93)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bradshaw, JJ; Ivanetich, KM; Ziman, MR1
Fischer, PW; Marks, GS; Morgan, RO; Stephens, JK1
Guzelian, PS; Swisher, RW1
Aden, D; Rovera, G; Surrey, S1
Kappas, A; Sassa, S1
Ferizovic, A; Fischer, PW; Marks, GS; Neilson, IR1
Liem, H; Muller-Eberhard, U; Smith, A1
Farrell, GC; Kunze, KL; Ortiz de Montellano, PR; Schmid, R1
De Matteis, F; Gibbs, AH; Unseld, A1
Kappas, A; Maines, MD2
Mico, BA; Ortiz de Montellano, PR; Yost, GS1
Capuano, A; Maestri, P; Pinelli, A1
de Matteis, F; Unseld, A2
Correia, MA; Farrell, GC; Mico, BA; Ortiz de Montellano, PR; Schmid, R; Yost, GS1
Janousĕk, V; Kappas, A; Maines, MD; Tomio, JM1
Bickers, DR; Harber, LC; Kappas, A; Keogh, L; Rifkind, AB1
Liem, HH; Miyai, K; Muller-Eberhard, U1
Bissell, DM; Hammaker, LE1
Ketterer, B; Singh Srai, K; Tipping, E1
McDonagh, AF; Meyer, UA; Pospisil, R1
Granick, S; Sinclair, PR1
Padmanaban, G; Rajamanickam, C; Rao, MR1
Deitrich, RA; Erwin, G; Troxell, PA1
Alcedo, JA; Bement, WJ; Hamilton, JW; Sinclair, JF; Sinclair, PR; Wetterhahn, KE1
Batlle, AM; Dinger, RM; Navone, NM; Polo, CF1
Atsmon, A; Bomstein, Y; Mamet, R; Mevasser, R; Schoenfeld, N1
Afonso, SG; Batlle, AM; Buzaleh, AM; Navone, NM; Polo, CF; Schoua, E; Vazquez, ES1
Atsmon, A; Bomstein, Y; Lahav, M; Mamet, R; Mevasser, R; Schoenfeld, N1
Ades, IZ; Lorber, BJ1
Bawden, MJ; Elliott, WH; Hansen, AJ; May, BK1
Datta, K; Prasad, AR1
Hansen, AJ; May, BK1
Bawden, MJ; Hansen, AJ; May, BK; Srivastava, G1
Drummond, GS; Smith, TJ1
Bonkovsky, HL; Healey, JF; Robinson, JM; Shedlofsky, SI; Sinclair, PR; Swim, AT1
Ades, IZ; Drew, PD; Stevens, TM1
Lindén, IB; Tenhunen, R; Tokola, O1
Bhat, GJ; Dwarki, VJ; Francis, VN; Padmanaban, G1
Britt, SG; Davies, HW; Pohl, LR2
Ades, IZ; Drew, PD1
Correia, MA; Farrell, GC; Gollan, JL; Settle, W; Wyman, JF1
Abraham, NG; Freedman, ML; Levere, RD1
Bornheim, LM; Correia, MA; Kotake, AN1
Atsmon, A; Epstein, O; Greenblat, Y; Schoenfeld, N2
Strik, JJ1
Gayathri, AK; Padmanaban, G1
Padmanaban, G; Rao, MR1
Kikuchi, G; Kim, HJ; Oashi, A; Tomita, Y; Watarai, K1
Agliati, A; Capuano, A; Pinelli, A1
Goldenberg, GJ; Israels, LG; Schacter, BA; Yoda, B1
De Matteis, F1
Beattie, DS; Patton, GM1
Lacroix, S; Rothwell, JD; Sweeney, GD1
Abbritti, G; De Matteis, F; Gibbs, AH1
Malathi, K; Padmanaban, G; Rao, MR1
Joubert, SM; Shanley, BC1
Cheng, LC; Orten, JM; Weissman, EB1
Badawy, AA; Evans, M1
Bonkowsky, HL; Elder, GH; Healey, JF; Shedlofsky, SI; Sinclair, JF; Sinclair, PR1
Cánepa, ET; Grinstein, M; Llambías, EB1
Schmid, R1
Badawy, AA; Morgan, CJ2
Bonkovsky, HL; Healey, JF; Sinclair, JF; Sinclair, PR; Smith, EL1
Burk, RF; Correia, MA1
Hayashi, N; Kikuchi, G; Yamamoto, M3
Alvares, AP; Eiseman, JL; Foidart, M; Muller-Eberhard, U1
Langry, KC; Ortiz de Montellano, PR; Stearns, RA1
Hayashi, N; Kikuchi, G1
Johnson, EF; Liem, HH; Muller-Eberhard, U1
Bloomer, JR; Morton, KO; Reuter, RJ; Wehner, JM1
Fagard, R; Guguen-Guillouzo, C1
Percy, VA; Shanley, BC1
Ibrahim, NG; Levere, RD; Nelson, JC1
Maines, MD2
Cantoni, L; De Matteis, F; Francis, J; Gibbs, AH1
Badawy, AA; Morgan, CJ; Welch, AN1
Beilan, HS; Correia, MA; Farrell, GC; Kunze, KL; Mico, BA; Olson, S; Ortiz de Montellano, PR; Schmid, R; Wong, JS1
Correia, MA; Farrell, GC; Gollan, JL; Schmid, R1
Gidari, AS; Yeung, TC1
Dinizo, SE; Kunze, KL; Marks, GS; Mico, BA; Ortiz de Montellano, PR; Zimmer, SB1
Bonkowsky, HL; Healey, JF; Pomeroy, JS; Sinclair, JF; Sinclair, PR1
Hayashi, N; Kikuchi, G; Yamauchi, K1
Bonkowsky, HL; Erny, R; Healey, JF; Mayer, YP; Sinclair, PR1
Baird, MB1
Klinger, W; Müller, D1
Correia, MA; Farrell, GC1
Hayashi, N; Kikuchi, G; Terasawa, M1
Brooker, JD; Elliott, WH; May, BK; Srivastava, G1
Brooker, JD; Elliott, WH; Lim, LK; May, BK; Srivastava, G1
Batlle, AM; Caballero, FA; Gerez, EN; Polo, CF; Vázquez, ES1
Bissbort, SH; Myburgh, S; Van Brummelen, R1
Golly, I; Hlavica, P1
Bonkovsky, HL; Cable, EE; Donohue, SE; Gildemeister, OS; Lambrecht, RW; Pepe, JA1
Batlle, A; Caballero, F; Gerez, E; Polo, C; Vazquez, E1
Buzaleh, AM; del Camen Martinez, M; del Carmen Batlle, AM1
Arison, B; Correia, MA; Gavrilovich Zgoda, V; Ingelman-Sundberg, M; Mkrtchian, S1
Lelli, SM; Mazzetti, MB; San Martín de Viale, LC1
Laftah, AH; Peters, TJ; Raja, KB; Simpson, RJ1
Faut, M; Mazzetti, MB; Paiz, A; San Martín de Viale, LC1

Reviews

4 review(s) available for heme and allylisopropylacetamide

ArticleYear
Hormonal effects on the regulation of hepatic heme biosynthesis.
    Molecular and cellular biochemistry, 1979, May-21, Volume: 25, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Androstanes; Animals; Bucladesine; Chick Embryo; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucose; Heme; Hormones; Humans; Hydrocortisone; Insulin; Ketosteroids; Liver; Porphyrias; Porphyrins; Pregnanes; Structure-Activity Relationship; Thyroid Hormones

1979
Increased liver haem degradation caused by foreign chemicals: a comparison of the effects of 2-allyl-2-isopropylacetamide and cobaltous chloride.
    Biochemical Society transactions, 1976, Volume: 4, Issue:2

    Topics: Acetamides; Allylisopropylacetamide; Animals; Bile Ducts; Bilirubin; Cobalt; Heme; Liver; Male; Mixed Function Oxygenases; Pigments, Biological; Rats; Time Factors

1976
Hepatic heme metabolism: new aspects and speculations.
    Seminars in liver disease, 1983, Volume: 3, Issue:1

    Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Microsomes, Liver; Phenobarbital; Rats

1983
Regulation by heme of synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver.
    Molecular and cellular biochemistry, 1981, Jun-09, Volume: 37, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biological Transport; Cell-Free System; Cobalt; Cytosol; Dicarbethoxydihydrocollidine; Heme; Hemin; Immunodiffusion; Leucine; Liver; Mitochondria, Liver; Molecular Weight; Protoporphyrins; Rabbits; Rats; Tryptophan Oxygenase

1981

Other Studies

103 other study(ies) available for heme and allylisopropylacetamide

ArticleYear
The degradation of different forms of cytochrome P-450 in vivo by fluroxene and allyl-iso-propylacetamide.
    Biochemical and biophysical research communications, 1978, Dec-14, Volume: 85, Issue:3

    Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Ethers; Heme; Male; Methylcholanthrene; Microsomes, Liver; Pentobarbital; Proteins; Rats

1978
Degradation of cytochrome P-450 haem by carbon tetrachloride and 2-allyl-2-isopropylacetamide in rat liver in vivo and in vitro. Involvement of non-carbon monoxide-forming mechanisms.
    The Biochemical journal, 1979, Dec-15, Volume: 184, Issue:3

    Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Kidney; Lipid Metabolism; Liver; Male; Microsomes, Liver; Rats

1979
Allylisopropylacetamide restricts expression of beta minor globin gene in Friend cells.
    Nature, 1978, Mar-09, Volume: 272, Issue:5649

    Topics: Acetamides; Allylisopropylacetamide; Animals; Cell Line; Dimethyl Sulfoxide; Erythropoiesis; Friend murine leukemia virus; Genes; Globins; Heme; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Macromolecular Substances

1978
Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process.
    The Journal of biological chemistry, 1977, Apr-10, Volume: 252, Issue:7

    Topics: 5-Aminolevulinate Synthetase; Aged; Allylisopropylacetamide; Cells, Cultured; Culture Media; Enzyme Induction; Heme; Humans; Hydrocortisone; Insulin; Kinetics; Liver; Microscopy, Phase-Contrast; Perfusion; Porphyrins; Spectrometry, Fluorescence; Spectrophotometry; Triiodothyronine

1977
Porphyrin-inducing activity of alfaxolone and alfadolone acetate in chick embryo liver cells.
    Anesthesiology, 1979, Volume: 50, Issue:4

    Topics: Alfaxalone Alfadolone Mixture; Allylisopropylacetamide; Animals; Chick Embryo; Heme; Liver; Porphyrins; Pregnanediones; Thiopental

1979
Effect of desferrioxamine and chronic iron deficiency of heme metabolism--comparison with the porphyrogens 2-allyl-2-isopropylacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
    Biochemical pharmacology, 1979, Jun-01, Volume: 28, Issue:11

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Deferoxamine; Dicarbethoxydihydrocollidine; Heme; Iron Deficiencies; Liver; Male; Mitochondria, Liver; Porphyrins; Pyridines; Rats; Time Factors

1979
Exogenous heme restores in vivo functional capacity of hepatic cytochrome P-450 destroyed by allylisopropylacetamide.
    Biochemical and biophysical research communications, 1979, Jul-27, Volume: 89, Issue:2

    Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats

1979
Loss of haem from cytochrome P-450 caused by lipid peroxidation and 2-allyl-2-isoprophylacetamide. An abnormal pathway not involving production of carbon monoxide.
    The Biochemical journal, 1977, Dec-15, Volume: 168, Issue:3

    Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Metabolism; Male; Microsomes, Liver; Peroxides; Rats

1977
Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation.
    The Journal of biological chemistry, 1978, Apr-10, Volume: 253, Issue:7

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Animals, Newborn; Enzyme Induction; Erythrocytes; Ferrochelatase; Guinea Pigs; Heme; Hydroxymethylbilane Synthase; Kidney; Liver; Oxygenases; Rats; Species Specificity

1978
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct.
    Biochemical and biophysical research communications, 1978, Jul-14, Volume: 83, Issue:1

    Topics: Acetamides; Allylisopropylacetamide; Animals; Binding Sites; Cytochrome P-450 Enzyme Inhibitors; Heme; Liver; Phenobarbital; Protein Binding; Rats; Spectrophotometry

1978
Antiporphyric activity of theophylline in normal and allylisopropylacetaminde-treated rats.
    Biochemical pharmacology, 1978, Volume: 27, Issue:13

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Female; Heme; Liver; Microsomes, Liver; Organ Size; Porphyrins; Rats; Theophylline

1978
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.
    The International journal of biochemistry, 1978, Volume: 9, Issue:12

    Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Paralysis; Phenobarbital; Rats; Sleep; Zoxazolamine

1978
Incorporation of exogenous heme into hepatic cytochrome P-450 in vivo.
    The Journal of biological chemistry, 1979, Jan-10, Volume: 254, Issue:1

    Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Subcellular Fractions

1979
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.
    Proceedings of the National Academy of Sciences of the United States of America, 1976, Volume: 73, Issue:5

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Enzyme Induction; Heme; Hydroxymethylbilane Synthase; Liver; Lyases; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Porphyrins; Rats

1976
Studies in porphyria. VI. Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients.
    The Journal of investigative dermatology, 1977, Volume: 68, Issue:1

    Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Heme; Humans; Hydroxymethylbilane Synthase; Levulinic Acids; Liver; Male; Mice; Organ Culture Techniques; Porphyrias; Porphyrins; Rats; Skin

1977
Effect of porphyrinogenic agents on protein synthesis and bilirubin formation by the isolated perfused rat liver.
    Biochimica et biophysica acta, 1977, Jan-24, Volume: 496, Issue:1

    Topics: Acetamides; Adenine Nucleotides; Allylisopropylacetamide; Animals; Bilirubin; Blood Proteins; Chelating Agents; Dicarbethoxydihydrocollidine; Heme; Iron; Liver; Male; Perfusion; Pyridines; Rats

1977
Cytochrome p-450 heme and the regulation of delta-aminolevulinic acid synthetase in the liver.
    Archives of biochemistry and biophysics, 1976, Volume: 176, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Endotoxins; Enzyme Induction; Heme; Kinetics; Liver; Male; Oxygenases; Protoporphyrins; Rats

1976
Binding by proteins of the rat liver cytosol of compounds derived in vivo from the haem precursor 5-aminolaevulinic acid.
    Biochemical Society transactions, 1976, Volume: 4, Issue:2

    Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Carrier Proteins; Cytosol; Heme; Levulinic Acids; Liver; Mixed Function Oxygenases; Rats

1976
Degradation of hepatic haem to porphyrins and oxophlorins in rats treated with 2-allyl-2-isopropylacetamide.
    Biochemical Society transactions, 1976, Volume: 4, Issue:2

    Topics: Acetamides; Allylisopropylacetamide; Animals; Chromatography, Thin Layer; Heme; Liver; Male; Pigments, Biological; Porphyrins; Rats

1976
Heme control on the synthesis of delta-aminolevulinic acid synthetase in cultured chick embryo liver cells.
    Annals of the New York Academy of Sciences, 1975, Apr-15, Volume: 244

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Deferoxamine; Enzyme Induction; Heme; Hemin; Kinetics; Lead; Levulinic Acids; Liver; Phenobarbital; Protein Biosynthesis; Transcription, Genetic

1975
On the sequence of reactions leading to cytochrome P-450 synthesis-effect of drugs.
    The Journal of biological chemistry, 1975, Mar-25, Volume: 250, Issue:6

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Apoproteins; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Endoplasmic Reticulum; Glycine; Heme; Iron; Liver; Male; Microsomes, Liver; Phenobarbital; Rats

1975
Characteristics of the induction of aldehyde dehydrogenase in rat liver.
    Archives of biochemistry and biophysics, 1975, Volume: 166, Issue:2

    Topics: Aldehyde Oxidoreductases; Allylisopropylacetamide; Animals; Cycloheximide; Cytosol; Enzyme Induction; Heme; Liver; Phenobarbital; Rats; Species Specificity; Time Factors

1975
Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450.
    The Journal of biological chemistry, 1975, Jun-10, Volume: 250, Issue:11

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Bilirubin; Cobalt; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dactinomycin; Ethylmorphine-N-Demethylase; Heme; Iodides; Liver; Microsomes, Liver; Oxygen Consumption; Porphyrins; Puromycin; Rats; Thiocyanates; Time Factors; Triazoles; Urea

1975
Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription.
    Archives of biochemistry and biophysics, 1991, Volume: 289, Issue:2

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Deferoxamine; Gene Expression Regulation, Enzymologic; Half-Life; Heme; Liver; Models, Biological; RNA, Messenger; Transcription, Genetic

1991
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice--I. Effect of allyl-isopropylacetamide and veronal on delta-aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase.
    The International journal of biochemistry, 1990, Volume: 22, Issue:9

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Barbital; Cytochrome P-450 Enzyme System; Electron Transport Complex IV; Enzyme Induction; Heme; Liver; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C

1990
L-Alanine: 4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver.
    Biochimica et biophysica acta, 1990, May-16, Volume: 1034, Issue:2

    Topics: Alanine; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Chick Embryo; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Liver; Male; Phenobarbital; Porphyrins; Rats; Rats, Inbred Strains; Transaminases; Valerates

1990
In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway.
    General pharmacology, 1990, Volume: 21, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Colchicine; Enzyme Induction; Griseofulvin; Heme; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Porphyrins; Vincristine

1990
Regulation of heme synthesis in the regenerating rat liver.
    Biochemical medicine and metabolic biology, 1990, Volume: 43, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarbethoxydihydrocollidine; Heme; Liver Regeneration; Male; Rats; Rats, Inbred Strains

1990
Regulation of biogenesis of liver delta-aminolevulinate synthase: effects of structural modifications of heme on the enzyme's RNA.
    The International journal of biochemistry, 1989, Volume: 21, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Enzyme Induction; Heme; Hemin; Liver; Metalloporphyrins; RNA; Structure-Activity Relationship

1989
Regulation of genes associated with drug metabolism.
    Biochemical Society symposium, 1989, Volume: 55

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Amino Acid Sequence; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Activation; Gene Expression Regulation; Heme; Humans; Inactivation, Metabolic; Liver; Molecular Sequence Data; Phenobarbital; Rats; RNA, Messenger; Transcription, Genetic; Transcriptional Activation

1989
Synergistic effect of allyl isopropyl acetamide with cadmium on hepatic heme synthesis in chick embryo.
    The Indian journal of medical research, 1989, Volume: 90

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cadmium; Chick Embryo; Dose-Response Relationship, Drug; Drug Synergism; Heme; Liver; Porphobilinogen Synthase

1989
Effect of haem on cytochrome P-450 synthesis.
    Clinical and experimental pharmacology & physiology, 1989, Volume: 16, Issue:6

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation; Heme; Heptanoates; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; RNA, Messenger; Steroid 11-beta-Hydroxylase

1989
Heme may not be a positive regulator of cytochrome-P450 gene expression.
    European journal of biochemistry, 1989, Jan-02, Volume: 178, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Gene Expression Regulation; Genes; Heme; Humans; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Transcription, Genetic

1989
Thyroid hormone regulation of heme synthesis in rat liver.
    Endocrinology, 1988, Volume: 122, Issue:5

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Heme; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Thyroidectomy; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse

1988
Haem synthesis from exogenous 5-aminolaevulinate in cultured chick-embryo hepatocytes. Effects of inducers of cytochromes P-450.
    The Biochemical journal, 1987, Nov-15, Volume: 248, Issue:1

    Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Induction; Heme; Levulinic Acids; Liver; Methylcholanthrene; Porphobilinogen; Porphyrins

1987
Biogenesis of embryonic chick liver delta-aminolevulinate synthase: regulation of the level of mRNA by hemin.
    Archives of biochemistry and biophysics, 1987, Volume: 253, Issue:2

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; DNA; Heme; Hemin; Liver; Nucleic Acid Hybridization; Polyribosomes; Protein Biosynthesis; RNA, Messenger

1987
The effects of haem arginate and haematin upon the allylisopropylacetamide induced experimental porphyria in rats.
    Pharmacology & toxicology, 1987, Volume: 61, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Arginine; Heme; Hemin; Liver; Male; Porphobilinogen; Porphyrias; Rats; Rats, Inbred Strains

1987
Regulation of cytochrome P-450 messenger RNA and apoprotein levels by heme.
    The Journal of biological chemistry, 1987, Dec-15, Volume: 262, Issue:35

    Topics: Allylisopropylacetamide; Amitrole; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Hemin; Male; Phenobarbital; Rats; RNA, Messenger

1987
Inactivation of cytochrome P-450 by 2-isopropyl-4-pentenamide and other xenobiotics leads to heme-derived protein adducts.
    Chemico-biological interactions, 1986, Volume: 58, Issue:3

    Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme Inhibitors; Heme; Male; Microsomes, Liver; NADP; Porphyrins; Protein Binding; Proteins; Rats; Rats, Inbred Strains

1986
Regulation of production of embryonic chick liver delta-aminolevulinate synthase: effects of testosterone and of hemin on the mRNA of the enzyme.
    Biochemical and biophysical research communications, 1986, Oct-15, Volume: 140, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Dicarbethoxydihydrocollidine; Heme; Hemin; Liver; RNA, Messenger; Testosterone

1986
Incorporation of haemoglobin haem into the rat hepatic haemoproteins tryptophan pyrrolase and cytochrome P-450.
    The Biochemical journal, 1986, Sep-15, Volume: 238, Issue:3

    Topics: Allylisopropylacetamide; Animals; Bile; Cytochrome P-450 Enzyme System; Heme; Hemoglobins; Liver; Male; Methemoglobin; Perfusion; Porphyrins; Rats; Rats, Inbred Strains; Tryptophan Oxygenase

1986
Effect of age on rat liver heme and drug metabolism.
    Experimental gerontology, 1985, Volume: 20, Issue:5

    Topics: 5-Aminolevulinate Synthetase; Aging; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Heme Oxygenase (Decyclizing); Hemin; Liver; Microsomes, Liver; Oxygenases; Porphobilinogen Synthase; Rats; Rats, Inbred Strains

1985
Carbon tetrachloride and 2-isopropyl-4-pentenamide-induced inactivation of cytochrome P-450 leads to heme-derived protein adducts.
    Archives of biochemistry and biophysics, 1986, Volume: 244, Issue:1

    Topics: Acetamides; Allylisopropylacetamide; Animals; Binding Sites; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Electrophoresis; Heme; Immunochemistry; In Vitro Techniques; Male; Microsomes, Liver; Protein Binding; Proteins; Rats

1986
Differential haemin-mediated restoration of cytochrome P-450 N-demethylases after inactivation by allylisopropylacetamide.
    The Biochemical journal, 1985, Apr-01, Volume: 227, Issue:1

    Topics: Acetamides; Allylisopropylacetamide; Animals; Chromatography, DEAE-Cellulose; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; Heme; Hemin; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Proteins; Rats; Rats, Inbred Strains

1985
The influence of carbamazepine on the heme biosynthetic pathway.
    Biochemical medicine, 1985, Volume: 34, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Carbamazepine; Cells, Cultured; Chick Embryo; Drug Synergism; Heme; Hydroxymethylbilane Synthase; Liver; Porphobilinogen Synthase; Porphyrins; Proteins; Time Factors; Uroporphyrinogen Decarboxylase

1985
Chemical porphyria in Japanese quail (Coturnix c. Japonica).
    Enzyme, 1973, Volume: 16, Issue:1

    Topics: Allylisopropylacetamide; Animals; Bile; Biphenyl Compounds; Bromine; Coturnix; Dicarboxylic Acids; Environmental Pollution; Feedback; Female; Glutamate Dehydrogenase; Heme; Hexachlorocyclohexane; Kidney; Liver; Male; Mitochondria, Liver; Polychlorinated Biphenyls; Porphyrias; Porphyrins; Pyridines; Spectrometry, Fluorescence; Time Factors

1973
Biochemical effects of 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mouse liver.
    Biochemical pharmacology, 1974, Oct-01, Volume: 23, Issue:19

    Topics: Allylisopropylacetamide; Aniline Compounds; Animals; Carbon Radioisotopes; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dicarboxylic Acids; Female; Heme; Iron Radioisotopes; Kinetics; Leucine; Lipid Metabolism; Liver; Mice; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Organ Size; Phenobarbital; Phospholipids; Protein Biosynthesis; Pyridines; Ribonucleases; RNA

1974
Biochemical effects of the porphyrinogenic drug allylisopropylacetamide. A comparative study with phenobarbital.
    The Biochemical journal, 1973, Volume: 134, Issue:4

    Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Female; Heme; Liver; Microsomes, Liver; Organ Size; Phenobarbital; Phospholipids; Proteins; Rats; Ribonucleases; RNA

1973
Comparative study on induction of hepatic delta-aminolevulinate synthetase by different drugs.
    Enzyme, 1973, Volume: 16, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Bucladesine; Cells, Cultured; Chick Embryo; Cycloheximide; Cytosol; Dicarboxylic Acids; Enzyme Induction; Heme; Liver; Mitochondria, Liver; Phenobarbital; Pyridines; Rats; Species Specificity; Time Factors

1973
Antiporphyric effect exerted by caffeine administration in allylisopropylacetamide-treated rats.
    Pharmacological research communications, 1974, Volume: 6, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Caffeine; Cytochrome P-450 Enzyme System; Female; Heme; Liver; Microsomes, Liver; Organ Size; Porphyrins; Proteins; Rats

1974
Delta-aminolevulinic acid transport and synthesis, porphyrin synthesis and heme catabolism in chick embryo liver and heart cells.
    Biochimica et biophysica acta, 1974, Nov-04, Volume: 372, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Biological Transport; Carbon Radioisotopes; Chick Embryo; Chromatography, Ion Exchange; Coenzyme A Ligases; Dicarboxylic Acids; Enzyme Induction; Heart; Heme; Kinetics; Levulinic Acids; Liver; Myocardium; Organ Specificity; Oxygenases; Porphyrins; Pyridines; Regression Analysis; Rhodobacter sphaeroides; Succinates; Time Factors

1974
The effects of drugs on the activities of 5-aminolaevulinate synthetase and other enzymes in the pathway of haem biosynthesis.
    The Biochemical journal, 1972, Volume: 130, Issue:2

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarboxylic Acids; Esters; Griseofulvin; Heme; Liver; Mice; Phenobarbital; Phenylbutazone; Porphyrias; Pyridines; Rats

1972
Studies on hepatic -aminolevulinic acid synthetase.
    The Journal of biological chemistry, 1973, Jun-25, Volume: 248, Issue:12

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Carbon Isotopes; Citrates; Coenzyme A; Enzyme Induction; Freezing; Heme; Ketoglutaric Acids; Male; Membranes; Microsomes, Liver; Mitochondria, Liver; Picolines; Porphyrias; Rats; Subcellular Fractions; Succinates; Vibration

1973
Evidence against a regulatory role for heme oxygenase in hepatic heme synthesis.
    Biochimica et biophysica acta, 1973, May-28, Volume: 304, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Spleen; Starvation

1973
Decreased liver activity of porphyrin-metal chelatase in hepatic porphyria caused by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Studies in rats and mice.
    The Biochemical journal, 1973, Volume: 134, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chemical and Drug Induced Liver Injury; Cycloheximide; Dicarboxylic Acids; Heme; Iron; Iron Radioisotopes; Levulinic Acids; Liver Diseases; Lyases; Male; Mice; Mitochondria, Liver; Porphyrias; Porphyrins; Proadifen; Pyridines; Rats; Species Specificity

1973
A model for the regulation of delta-aminolaevulinate synthetase induction in rat liver.
    The Biochemical journal, 1973, Volume: 134, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Adrenalectomy; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Castration; Citrates; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Female; Heme; Hydrocortisone; Iron Radioisotopes; Liver; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Protein Binding; Rats

1973
Transfer of hydrogen via tricarboxylic acid cycle activity to liver aspartate and glutamate in normal rats and to liver haem in normal and in allylisopropylacetamide-treated rats.
    Enzyme, 1973, Volume: 16, Issue:1

    Topics: Acetamides; Allylisopropylacetamide; Animals; Aspartic Acid; Citric Acid Cycle; Ethanol; Female; Glutamates; Glycine; Heme; Hydrogen; Liver; Malates; Propionates; Rats; Succinates; Tritium

1973
The role of certain 5beta-H-steroids in the regulation of porphyrin-heme formation.
    Enzyme, 1973, Volume: 16, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cholesterol; Cyclohexanes; Female; Heme; Hypercholesterolemia; Mice; Mitochondria, Liver; Porphyrins; Pregnanes; Pyridines; Spectrophotometry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

1973
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.
    The Biochemical journal, 1973, Volume: 136, Issue:4

    Topics: Acetamides; Allylisopropylacetamide; Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dicarboxylic Acids; Griseofulvin; Heme; Humans; Hydrocortisone; Levulinic Acids; Liver; Male; Mental Disorders; Microsomes; Phenobarbital; Phenylbutazone; Porphyrias; Proadifen; Protein Precursors; Pyridines; Rats; Starvation; Time Factors; Tryptophan; Tryptophan Oxygenase

1973
Iron and the liver: acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase.
    The Journal of clinical investigation, 1983, Volume: 71, Issue:5

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Dextrans; Drug Synergism; Heme; Iron; Liver; Male; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Inbred Strains; Uroporphyrinogen Decarboxylase

1983
Effect of glucose on the induction of delta-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide.
    Biochimica et biophysica acta, 1984, May-22, Volume: 804, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Bucladesine; Carbohydrates; Cycloheximide; Enzyme Induction; Ferrochelatase; Gene Expression Regulation; Glucose; Heme; Liver; Lyases; Male; Rats

1984
Tryptophan pyrrolase in haem regulation. The relationship between the depletion of rat liver tryptophan pyrrolase haem and the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide.
    The Biochemical journal, 1980, Mar-15, Volume: 186, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Heme; Hexobarbital; Kinetics; Liver; Male; Methylphenazonium Methosulfate; Niacinamide; Rats; Tryptophan Oxygenase

1980
Formation of cytochrome P-450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide.
    The Biochemical journal, 1984, Sep-01, Volume: 222, Issue:2

    Topics: Acetamides; Allylisopropylacetamide; Animals; Apoenzymes; Cytochrome P-450 Enzyme System; Heme; Immunoelectrophoresis; In Vitro Techniques; Liver; Male; Phenobarbital; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Spectrophotometry

1984
Defective utilization of haem in selenium-deficient rat liver.
    The Biochemical journal, 1983, Jul-15, Volume: 214, Issue:1

    Topics: Allylisopropylacetamide; Animals; Heme; Liver; Male; Microsomes, Liver; Rats; Selenium; Tryptophan; Tryptophan Oxygenase

1983
Translational inhibition by heme of the synthesis of hepatic delta-aminolevulinate synthase in a cell-free system.
    Biochemical and biophysical research communications, 1983, Aug-30, Volume: 115, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cell-Free System; Heme; Kinetics; Liver; Male; Polyribosomes; Protein Biosynthesis; Rats; Rats, Inbred Strains

1983
Effect of heme on allylisopropylacetamide-induced changes in heme and drug metabolism in the rhesus monkey (Macaca mulatta).
    Biochemical pharmacology, 1983, Dec-15, Volume: 32, Issue:24

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Enzyme Activation; Ethylmorphine-N-Demethylase; Female; Heme; Heme Oxygenase (Decyclizing); Macaca mulatta; Microsomes, Liver; Porphyrias; Porphyrins

1983
The allylisopropylacetamide and novonal prosthetic heme adducts.
    Molecular pharmacology, 1984, Volume: 25, Issue:2

    Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Magnetic Resonance Spectroscopy; Phenobarbital; Rats; Structure-Activity Relationship

1984
The effect in vivo and in vitro of allylisopropylacetamide on the content of hepatic microsomal cytochrome P-450 2 of phenobarbital treated rabbits.
    Biochemical and biophysical research communications, 1983, Mar-29, Volume: 111, Issue:3

    Topics: Acetamides; Allylisopropylacetamide; Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Microsomes, Liver; NADP; Phenobarbital; Rabbits

1983
Enzymatic formation of zinc-protoporphyrin by rat liver and its potential effect on hepatic heme metabolism.
    Gastroenterology, 1983, Volume: 85, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Depression, Chemical; Enzyme Induction; Feedback; Ferrochelatase; Heme; Liver; Lyases; Male; Mitochondria, Liver; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Stimulation, Chemical

1983
The effect of hemin and of allyl isopropyl acetamide on protein synthesis in rat hepatocytes.
    Biochemical and biophysical research communications, 1983, Jul-29, Volume: 114, Issue:2

    Topics: Acetamides; Allylisopropylacetamide; Animals; Eukaryotic Initiation Factor-2; Heme; Liver; Male; Molecular Weight; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Polyribosomes; Protein Biosynthesis; Proteins; Rabbits; Rats; Rats, Inbred Strains; Reticulocytes; Tryptophan Oxygenase

1983
Factors affecting haem degradation in rat brain.
    Biochemical pharmacology, 1980, Jun-01, Volume: 29, Issue:11

    Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Biotransformation; Brain; Female; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Lead; Liver; Phenobarbital; Rats

1980
Control of delta-aminolaevulinate synthase and haem oxygenase in chronic-iron-overloaded rats.
    The Biochemical journal, 1981, Oct-15, Volume: 200, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Heme; Heme Oxygenase (Decyclizing); Iron; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains

1981
Enhancement and inhibition of enzymes of heme metabolism by diethyl maleate in the rat kidney.
    Archives of biochemistry and biophysics, 1982, Volume: 216, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Ammonia-Lyases; Animals; Heme; Heme Oxygenase (Decyclizing); Hydroxymethylbilane Synthase; Kidney; Kinetics; Male; Maleates; Mixed Function Oxygenases; Porphobilinogen Synthase; Porphyrins; Rats; Rats, Inbred Strains

1982
Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins.
    Ciba Foundation symposium, 1980, Volume: 76

    Topics: Acetamides; Allylisopropylacetamide; Animals; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Heme; Liver; Pigments, Biological; Porphyrins; Rats; Secobarbital; Spectrophotometry

1980
Evidence for the transcriptional inhibition by heme of the synthesis of delta-aminolevulinate synthase in rat liver.
    Biochemical and biophysical research communications, 1982, Apr-14, Volume: 105, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Heme; Kinetics; Liver; Male; Polyribosomes; Rabbits; Rats; Rats, Inbred Strains; Reticulocytes; RNA, Messenger; Transcription, Genetic

1982
Tryptophan pyrrolase in haem regulation. The mechanisms of enhancement of rat liver 5-aminolaevulinate synthase activity by starvation and of the glucose effect on induction of the enzyme by 2-allyl-2-isopropylacetamide.
    The Biochemical journal, 1982, Sep-15, Volume: 206, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Enzyme Induction; Fructose; Glucose; Heme; Hydrocortisone; Liver; Male; Rats; Rats, Inbred Strains; Starvation; Sucrose; Tryptophan Oxygenase

1982
The effects of succinylacetone (4,6-dioxoheptanoic acid) on delta-aminolevulinate synthase activity and the content of heme in monolayers of chick embryo liver cells.
    Biochimica et biophysica acta, 1982, Dec-30, Volume: 721, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Drug Synergism; Enzyme Induction; Heme; Heptanoates; Heptanoic Acids; Levulinic Acids; Liver; Porphobilinogen Synthase

1982
Cytochrome P-450 heme moiety. The specific target in drug-induced heme alkylation.
    The Journal of biological chemistry, 1981, Jun-10, Volume: 256, Issue:11

    Topics: Alkylation; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Norethindrone; Rats; Tryptophan Oxygenase

1981
Heme enhances hexobarbital metabolism in perfused rat liver after drug-mediated destruction of cytochrome P-450.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:2

    Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Hemeproteins; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats

1981
Effects of porphyrinogenic (porphyria-producing) agents on avian embryonic hepatic glutathione S-transferase activity.
    Biochemical and biophysical research communications, 1981, May-15, Volume: 100, Issue:1

    Topics: Acetamides; Allylisopropylacetamide; Animals; Chick Embryo; Cyproterone; Cytochrome P-450 Enzyme System; Cytosol; Glutathione Transferase; Heme; Liver; Phenobarbital; Porphyrias

1981
Studies of the porphyrin-inducing activity of ethynyl compounds and conformationally restricted and unrestricted analogues of allylisopropylacetamide in chick embryo liver cell culture.
    Molecular pharmacology, 1981, Volume: 20, Issue:1

    Topics: Acetamides; Alkynes; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Heme; Liver; Molecular Conformation; Porphyrins

1981
Regulation of synthesis and intracellular translocation of delta-aminolevulinate synthase by heme and its relation to the heme saturation of tryptophan pyrrolase in rat liver.
    Archives of biochemistry and biophysics, 1981, Volume: 209, Issue:2

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytosol; Heme; Hemin; Liver; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains; Tryptophan Oxygenase

1981
Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism.
    The Biochemical journal, 1981, Apr-15, Volume: 196, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Heme; Iron; Iron-Dextran Complex; Liver; Male; Rats; Time Factors

1981
Translocation of delta-aminolevulinate synthase from the cytosol to the mitochondria and its regulation by hemin in the rat liver.
    The Journal of biological chemistry, 1980, Feb-25, Volume: 255, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biological Transport; Cytosol; Enzyme Induction; Female; Heme; Kinetics; Liver; Mitochondria, Liver; Rats

1980
Tryptophan pyrrolase in haem regulation. The mechanism of the permissive effect of cortisol on the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide in the adrenalectomized-rat liver.
    The Biochemical journal, 1980, Mar-15, Volume: 186, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Adrenalectomy; Allopurinol; Allylisopropylacetamide; Animals; Heme; Hydrocortisone; Liver; Male; Rats; Tryptophan Oxygenase

1980
Metabolism of hepatic haem and 'green pigments' in rats given 2-allyl-2-isopropylacetamide and ferric citrate. A new model for hepatic haem turnover.
    The Biochemical journal, 1980, May-15, Volume: 188, Issue:2

    Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Female; Ferric Compounds; Heme; Iron; Kinetics; Liver; Models, Biological; Organ Size; Pigments, Biological; Rats

1980
Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450.
    Biochemical and biophysical research communications, 1980, Aug-29, Volume: 95, Issue:4

    Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pregnenolone Carbonitrile; Rats

1980
The influence of allyl isopropyl acetamide on d-aminolevulinic acid synthetase and cytochrome P-450.
    Acta biologica et medica Germanica, 1980, Volume: 39, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Heme; Liver; Male; Microsomes, Liver; Rats

1980
Structural and functional reconstitution of hepatic cytochrome P-450 in vivo. Reversal of allylisopropylacetamide-mediated destruction of the hemoprotein by exogenous heme.
    The Journal of biological chemistry, 1980, Nov-10, Volume: 255, Issue:21

    Topics: Acetamides; Allylisopropylacetamide; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Ethylmorphine-N-Demethylase; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats

1980
Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver.
    The International journal of biochemistry, 1980, Volume: 12, Issue:5-6

    Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Deferoxamine; Glutathione; Heme; Iron; Kinetics; Lipid Peroxides; Liver; Male; Microsomes, Liver; Porphyrins; Rats

1980
Immunochemical studies of the turnover of delta-aminolevulinate synthase in rat liver mitochondria and the effect of hemin on it.
    Journal of biochemistry, 1980, Volume: 88, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cycloheximide; Cytosol; Heme; Immune Sera; Immunoassay; Kinetics; Liver; Mitochondria, Liver; Rats

1980
Haem control in experimental porphyria. The effect of haemin on the induction of delta-aminolaevulinate synthase in isolated chick-embryo liver cells.
    The Biochemical journal, 1980, Jun-15, Volume: 188, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Enzyme Induction; Heme; Hemin; In Vitro Techniques; Liver; Porphyrias

1980
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.
    The Biochemical journal, 1980, Sep-15, Volume: 190, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Microsomes, Liver; Phenobarbital; Porphyrias; Proadifen

1980
STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and alpha-tocopherol.
    Chemico-biological interactions, 1995, Apr-14, Volume: 95, Issue:3

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Heme; Male; Mice; Nucleoside Deaminases; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Streptozocin; Thiosulfate Sulfurtransferase; Vitamin E

1995
The influence of porphyrogenic drugs on the glyoxalase enzymes.
    Research communications in chemical pathology and pharmacology, 1993, Volume: 82, Issue:3

    Topics: Allylisopropylacetamide; Barbiturates; Chloramphenicol; Diazepam; Erythrocytes; Heme; Hemoglobins; Humans; Kinetics; Lactoylglutathione Lyase; Oxytetracycline; Porphyrias; Protoporphyrins; Spectrophotometry, Ultraviolet; Sulfamethazine; Thiolester Hydrolases

1993
Inactivation of phenobarbital-inducible rabbit-liver microsomal cytochrome P-450 by allylisopropylacetamide: impact on electron transfer.
    Biochimica et biophysica acta, 1993, Apr-05, Volume: 1142, Issue:1-2

    Topics: Allylisopropylacetamide; Amino Acids; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Electron Transport; Enzyme Induction; Heme; Microsomes, Liver; NAD; NADP; Phenobarbital; Proteins; Rabbits

1993
Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins.
    European journal of biochemistry, 1996, Aug-15, Volume: 240, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Dactinomycin; Deferoxamine; Enzyme Inhibitors; Glutethimide; Heme; Heptanoates; Kinetics; Liver; Metalloporphyrins; Porphobilinogen Synthase; Regression Analysis; RNA, Messenger

1996
Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis.
    Cancer biochemistry biophysics, 1999, Volume: 17, Issue:1-2

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Enzyme Induction; Enzyme Inhibitors; Glucuronidase; Glutathione Transferase; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Liver Neoplasms, Experimental; Male; Mice; Microsomes, Liver; Models, Biological; Oxidation-Reduction; p-Dimethylaminoazobenzene; Precancerous Conditions; Prodrugs; Sulfatases; Tryptophan Oxygenase

1999
Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: studies on the haem pathway.
    Clinical and experimental pharmacology & physiology, 2000, Volume: 27, Issue:10

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Ammonia-Lyases; Anesthetics, Inhalation; Animals; Cytochrome P-450 Enzyme System; Enflurane; Heme; Heme Oxygenase (Decyclizing); Hydroxymethylbilane Synthase; Imidazoles; Isoflurane; Liver; Mice; Microsomes, Liver

2000
Hemin-mediated restoration of allylisopropylacetamide-inactivated CYP2B1: a role for glutathione and GRP94 in the heme-protein assembly.
    Archives of biochemistry and biophysics, 2002, Dec-01, Volume: 408, Issue:1

    Topics: Allylisopropylacetamide; Animals; Antibodies; Benzoquinones; Cytochrome P-450 CYP2B1; Enzyme Inhibitors; Glutathione; Heme; Hemeproteins; HSP70 Heat-Shock Proteins; Kinetics; Lactams, Macrocyclic; Male; Membrane Proteins; Microsomes, Liver; Molecular Chaperones; Quinones; Rats; Rats, Sprague-Dawley

2002
Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species.
    Toxicology, 2005, Volume: 216, Issue:1

    Topics: Allylisopropylacetamide; Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Female; Glucose; Heme; Lipid Peroxidation; Liver; Luminescent Measurements; Porphyria, Acute Intermittent; Rats; Rats, Wistar; Reactive Oxygen Species; Urine

2005
The effect of haem biosynthesis inhibitors and inducers on intestinal iron absorption and liver haem biosynthetic enzyme activities.
    Toxicology and applied pharmacology, 2008, Jun-15, Volume: 229, Issue:3

    Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Antimicrobial Cationic Peptides; Duodenum; Enzyme Inhibitors; Heme; Hepcidins; Heptanoates; Intestinal Absorption; Iron Compounds; Male; Mice; Porphobilinogen; Porphobilinogen Synthase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2008
Alterations of the redox state, pentose pathway and glutathione metabolism in an acute porphyria model. Their impact on heme pathway.
    Experimental biology and medicine (Maywood, N.J.), 2013, Volume: 238, Issue:2

    Topics: Allylisopropylacetamide; Animals; Disease Models, Animal; Glucose; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Heme; Liver; NADP; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Porphyria, Acute Intermittent; Pyridines; Rats; Reactive Oxygen Species

2013
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