heme and allylisopropylacetamide
heme has been researched along with allylisopropylacetamide in 107 studies
Research
Studies (107)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 92 (85.98) | 18.7374 |
1990's | 10 (9.35) | 18.2507 |
2000's | 4 (3.74) | 29.6817 |
2010's | 1 (0.93) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Bradshaw, JJ; Ivanetich, KM; Ziman, MR | 1 |
Fischer, PW; Marks, GS; Morgan, RO; Stephens, JK | 1 |
Guzelian, PS; Swisher, RW | 1 |
Aden, D; Rovera, G; Surrey, S | 1 |
Kappas, A; Sassa, S | 1 |
Ferizovic, A; Fischer, PW; Marks, GS; Neilson, IR | 1 |
Liem, H; Muller-Eberhard, U; Smith, A | 1 |
Farrell, GC; Kunze, KL; Ortiz de Montellano, PR; Schmid, R | 1 |
De Matteis, F; Gibbs, AH; Unseld, A | 1 |
Kappas, A; Maines, MD | 2 |
Mico, BA; Ortiz de Montellano, PR; Yost, GS | 1 |
Capuano, A; Maestri, P; Pinelli, A | 1 |
de Matteis, F; Unseld, A | 2 |
Correia, MA; Farrell, GC; Mico, BA; Ortiz de Montellano, PR; Schmid, R; Yost, GS | 1 |
Janousĕk, V; Kappas, A; Maines, MD; Tomio, JM | 1 |
Bickers, DR; Harber, LC; Kappas, A; Keogh, L; Rifkind, AB | 1 |
Liem, HH; Miyai, K; Muller-Eberhard, U | 1 |
Bissell, DM; Hammaker, LE | 1 |
Ketterer, B; Singh Srai, K; Tipping, E | 1 |
McDonagh, AF; Meyer, UA; Pospisil, R | 1 |
Granick, S; Sinclair, PR | 1 |
Padmanaban, G; Rajamanickam, C; Rao, MR | 1 |
Deitrich, RA; Erwin, G; Troxell, PA | 1 |
Alcedo, JA; Bement, WJ; Hamilton, JW; Sinclair, JF; Sinclair, PR; Wetterhahn, KE | 1 |
Batlle, AM; Dinger, RM; Navone, NM; Polo, CF | 1 |
Atsmon, A; Bomstein, Y; Mamet, R; Mevasser, R; Schoenfeld, N | 1 |
Afonso, SG; Batlle, AM; Buzaleh, AM; Navone, NM; Polo, CF; Schoua, E; Vazquez, ES | 1 |
Atsmon, A; Bomstein, Y; Lahav, M; Mamet, R; Mevasser, R; Schoenfeld, N | 1 |
Ades, IZ; Lorber, BJ | 1 |
Bawden, MJ; Elliott, WH; Hansen, AJ; May, BK | 1 |
Datta, K; Prasad, AR | 1 |
Hansen, AJ; May, BK | 1 |
Bawden, MJ; Hansen, AJ; May, BK; Srivastava, G | 1 |
Drummond, GS; Smith, TJ | 1 |
Bonkovsky, HL; Healey, JF; Robinson, JM; Shedlofsky, SI; Sinclair, PR; Swim, AT | 1 |
Ades, IZ; Drew, PD; Stevens, TM | 1 |
Lindén, IB; Tenhunen, R; Tokola, O | 1 |
Bhat, GJ; Dwarki, VJ; Francis, VN; Padmanaban, G | 1 |
Britt, SG; Davies, HW; Pohl, LR | 2 |
Ades, IZ; Drew, PD | 1 |
Correia, MA; Farrell, GC; Gollan, JL; Settle, W; Wyman, JF | 1 |
Abraham, NG; Freedman, ML; Levere, RD | 1 |
Bornheim, LM; Correia, MA; Kotake, AN | 1 |
Atsmon, A; Epstein, O; Greenblat, Y; Schoenfeld, N | 2 |
Strik, JJ | 1 |
Gayathri, AK; Padmanaban, G | 1 |
Padmanaban, G; Rao, MR | 1 |
Kikuchi, G; Kim, HJ; Oashi, A; Tomita, Y; Watarai, K | 1 |
Agliati, A; Capuano, A; Pinelli, A | 1 |
Goldenberg, GJ; Israels, LG; Schacter, BA; Yoda, B | 1 |
De Matteis, F | 1 |
Beattie, DS; Patton, GM | 1 |
Lacroix, S; Rothwell, JD; Sweeney, GD | 1 |
Abbritti, G; De Matteis, F; Gibbs, AH | 1 |
Malathi, K; Padmanaban, G; Rao, MR | 1 |
Joubert, SM; Shanley, BC | 1 |
Cheng, LC; Orten, JM; Weissman, EB | 1 |
Badawy, AA; Evans, M | 1 |
Bonkowsky, HL; Elder, GH; Healey, JF; Shedlofsky, SI; Sinclair, JF; Sinclair, PR | 1 |
Cánepa, ET; Grinstein, M; Llambías, EB | 1 |
Schmid, R | 1 |
Badawy, AA; Morgan, CJ | 2 |
Bonkovsky, HL; Healey, JF; Sinclair, JF; Sinclair, PR; Smith, EL | 1 |
Burk, RF; Correia, MA | 1 |
Hayashi, N; Kikuchi, G; Yamamoto, M | 3 |
Alvares, AP; Eiseman, JL; Foidart, M; Muller-Eberhard, U | 1 |
Langry, KC; Ortiz de Montellano, PR; Stearns, RA | 1 |
Hayashi, N; Kikuchi, G | 1 |
Johnson, EF; Liem, HH; Muller-Eberhard, U | 1 |
Bloomer, JR; Morton, KO; Reuter, RJ; Wehner, JM | 1 |
Fagard, R; Guguen-Guillouzo, C | 1 |
Percy, VA; Shanley, BC | 1 |
Ibrahim, NG; Levere, RD; Nelson, JC | 1 |
Maines, MD | 2 |
Cantoni, L; De Matteis, F; Francis, J; Gibbs, AH | 1 |
Badawy, AA; Morgan, CJ; Welch, AN | 1 |
Beilan, HS; Correia, MA; Farrell, GC; Kunze, KL; Mico, BA; Olson, S; Ortiz de Montellano, PR; Schmid, R; Wong, JS | 1 |
Correia, MA; Farrell, GC; Gollan, JL; Schmid, R | 1 |
Gidari, AS; Yeung, TC | 1 |
Dinizo, SE; Kunze, KL; Marks, GS; Mico, BA; Ortiz de Montellano, PR; Zimmer, SB | 1 |
Bonkowsky, HL; Healey, JF; Pomeroy, JS; Sinclair, JF; Sinclair, PR | 1 |
Hayashi, N; Kikuchi, G; Yamauchi, K | 1 |
Bonkowsky, HL; Erny, R; Healey, JF; Mayer, YP; Sinclair, PR | 1 |
Baird, MB | 1 |
Klinger, W; Müller, D | 1 |
Correia, MA; Farrell, GC | 1 |
Hayashi, N; Kikuchi, G; Terasawa, M | 1 |
Brooker, JD; Elliott, WH; May, BK; Srivastava, G | 1 |
Brooker, JD; Elliott, WH; Lim, LK; May, BK; Srivastava, G | 1 |
Batlle, AM; Caballero, FA; Gerez, EN; Polo, CF; Vázquez, ES | 1 |
Bissbort, SH; Myburgh, S; Van Brummelen, R | 1 |
Golly, I; Hlavica, P | 1 |
Bonkovsky, HL; Cable, EE; Donohue, SE; Gildemeister, OS; Lambrecht, RW; Pepe, JA | 1 |
Batlle, A; Caballero, F; Gerez, E; Polo, C; Vazquez, E | 1 |
Buzaleh, AM; del Camen Martinez, M; del Carmen Batlle, AM | 1 |
Arison, B; Correia, MA; Gavrilovich Zgoda, V; Ingelman-Sundberg, M; Mkrtchian, S | 1 |
Lelli, SM; Mazzetti, MB; San Martín de Viale, LC | 1 |
Laftah, AH; Peters, TJ; Raja, KB; Simpson, RJ | 1 |
Faut, M; Mazzetti, MB; Paiz, A; San Martín de Viale, LC | 1 |
Reviews
4 review(s) available for heme and allylisopropylacetamide
Article | Year |
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Hormonal effects on the regulation of hepatic heme biosynthesis.
Topics: 1-Methyl-3-isobutylxanthine; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Androstanes; Animals; Bucladesine; Chick Embryo; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucose; Heme; Hormones; Humans; Hydrocortisone; Insulin; Ketosteroids; Liver; Porphyrias; Porphyrins; Pregnanes; Structure-Activity Relationship; Thyroid Hormones | 1979 |
Increased liver haem degradation caused by foreign chemicals: a comparison of the effects of 2-allyl-2-isopropylacetamide and cobaltous chloride.
Topics: Acetamides; Allylisopropylacetamide; Animals; Bile Ducts; Bilirubin; Cobalt; Heme; Liver; Male; Mixed Function Oxygenases; Pigments, Biological; Rats; Time Factors | 1976 |
Hepatic heme metabolism: new aspects and speculations.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Microsomes, Liver; Phenobarbital; Rats | 1983 |
Regulation by heme of synthesis and intracellular translocation of delta-aminolevulinate synthase in the liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biological Transport; Cell-Free System; Cobalt; Cytosol; Dicarbethoxydihydrocollidine; Heme; Hemin; Immunodiffusion; Leucine; Liver; Mitochondria, Liver; Molecular Weight; Protoporphyrins; Rabbits; Rats; Tryptophan Oxygenase | 1981 |
Other Studies
103 other study(ies) available for heme and allylisopropylacetamide
Article | Year |
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The degradation of different forms of cytochrome P-450 in vivo by fluroxene and allyl-iso-propylacetamide.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Ethers; Heme; Male; Methylcholanthrene; Microsomes, Liver; Pentobarbital; Proteins; Rats | 1978 |
Degradation of cytochrome P-450 haem by carbon tetrachloride and 2-allyl-2-isopropylacetamide in rat liver in vivo and in vitro. Involvement of non-carbon monoxide-forming mechanisms.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Kidney; Lipid Metabolism; Liver; Male; Microsomes, Liver; Rats | 1979 |
Allylisopropylacetamide restricts expression of beta minor globin gene in Friend cells.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cell Line; Dimethyl Sulfoxide; Erythropoiesis; Friend murine leukemia virus; Genes; Globins; Heme; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Macromolecular Substances | 1978 |
Induction of aminolevulinate synthase and porphyrins in cultured liver cells maintained in chemically defined medium. Permissive effects of hormones on induction process.
Topics: 5-Aminolevulinate Synthetase; Aged; Allylisopropylacetamide; Cells, Cultured; Culture Media; Enzyme Induction; Heme; Humans; Hydrocortisone; Insulin; Kinetics; Liver; Microscopy, Phase-Contrast; Perfusion; Porphyrins; Spectrometry, Fluorescence; Spectrophotometry; Triiodothyronine | 1977 |
Porphyrin-inducing activity of alfaxolone and alfadolone acetate in chick embryo liver cells.
Topics: Alfaxalone Alfadolone Mixture; Allylisopropylacetamide; Animals; Chick Embryo; Heme; Liver; Porphyrins; Pregnanediones; Thiopental | 1979 |
Effect of desferrioxamine and chronic iron deficiency of heme metabolism--comparison with the porphyrogens 2-allyl-2-isopropylacetamide and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Cytochromes; Deferoxamine; Dicarbethoxydihydrocollidine; Heme; Iron Deficiencies; Liver; Male; Mitochondria, Liver; Porphyrins; Pyridines; Rats; Time Factors | 1979 |
Exogenous heme restores in vivo functional capacity of hepatic cytochrome P-450 destroyed by allylisopropylacetamide.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats | 1979 |
Loss of haem from cytochrome P-450 caused by lipid peroxidation and 2-allyl-2-isoprophylacetamide. An abnormal pathway not involving production of carbon monoxide.
Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Metabolism; Male; Microsomes, Liver; Peroxides; Rats | 1977 |
Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Animals, Newborn; Enzyme Induction; Erythrocytes; Ferrochelatase; Guinea Pigs; Heme; Hydroxymethylbilane Synthase; Kidney; Liver; Oxygenases; Rats; Species Specificity | 1978 |
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct.
Topics: Acetamides; Allylisopropylacetamide; Animals; Binding Sites; Cytochrome P-450 Enzyme Inhibitors; Heme; Liver; Phenobarbital; Protein Binding; Rats; Spectrophotometry | 1978 |
Antiporphyric activity of theophylline in normal and allylisopropylacetaminde-treated rats.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Female; Heme; Liver; Microsomes, Liver; Organ Size; Porphyrins; Rats; Theophylline | 1978 |
Destruction of endogenous and exogenous haem by 2-allyl-2-isopropylacetamide: role of the liver cytochrome P-450 which is inducible by phenobarbitone.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Heme; Hexobarbital; Male; Methylcholanthrene; Microsomes, Liver; Paralysis; Phenobarbital; Rats; Sleep; Zoxazolamine | 1978 |
Incorporation of exogenous heme into hepatic cytochrome P-450 in vivo.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Subcellular Fractions | 1979 |
Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Enzyme Induction; Heme; Hydroxymethylbilane Synthase; Liver; Lyases; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Porphyrins; Rats | 1976 |
Studies in porphyria. VI. Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Heme; Humans; Hydroxymethylbilane Synthase; Levulinic Acids; Liver; Male; Mice; Organ Culture Techniques; Porphyrias; Porphyrins; Rats; Skin | 1977 |
Effect of porphyrinogenic agents on protein synthesis and bilirubin formation by the isolated perfused rat liver.
Topics: Acetamides; Adenine Nucleotides; Allylisopropylacetamide; Animals; Bilirubin; Blood Proteins; Chelating Agents; Dicarbethoxydihydrocollidine; Heme; Iron; Liver; Male; Perfusion; Pyridines; Rats | 1977 |
Cytochrome p-450 heme and the regulation of delta-aminolevulinic acid synthetase in the liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Carbon Dioxide; Cytochrome P-450 Enzyme System; Endotoxins; Enzyme Induction; Heme; Kinetics; Liver; Male; Oxygenases; Protoporphyrins; Rats | 1976 |
Binding by proteins of the rat liver cytosol of compounds derived in vivo from the haem precursor 5-aminolaevulinic acid.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Carrier Proteins; Cytosol; Heme; Levulinic Acids; Liver; Mixed Function Oxygenases; Rats | 1976 |
Degradation of hepatic haem to porphyrins and oxophlorins in rats treated with 2-allyl-2-isopropylacetamide.
Topics: Acetamides; Allylisopropylacetamide; Animals; Chromatography, Thin Layer; Heme; Liver; Male; Pigments, Biological; Porphyrins; Rats | 1976 |
Heme control on the synthesis of delta-aminolevulinic acid synthetase in cultured chick embryo liver cells.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Deferoxamine; Enzyme Induction; Heme; Hemin; Kinetics; Lead; Levulinic Acids; Liver; Phenobarbital; Protein Biosynthesis; Transcription, Genetic | 1975 |
On the sequence of reactions leading to cytochrome P-450 synthesis-effect of drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Apoproteins; Cycloheximide; Cytochrome P-450 Enzyme System; Dactinomycin; Endoplasmic Reticulum; Glycine; Heme; Iron; Liver; Male; Microsomes, Liver; Phenobarbital; Rats | 1975 |
Characteristics of the induction of aldehyde dehydrogenase in rat liver.
Topics: Aldehyde Oxidoreductases; Allylisopropylacetamide; Animals; Cycloheximide; Cytosol; Enzyme Induction; Heme; Liver; Phenobarbital; Rats; Species Specificity; Time Factors | 1975 |
Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Bilirubin; Cobalt; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dactinomycin; Ethylmorphine-N-Demethylase; Heme; Iodides; Liver; Microsomes, Liver; Oxygen Consumption; Porphyrins; Puromycin; Rats; Thiocyanates; Time Factors; Triazoles; Urea | 1975 |
Heme regulates hepatic 5-aminolevulinate synthase mRNA expression by decreasing mRNA half-life and not by altering its rate of transcription.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Deferoxamine; Gene Expression Regulation, Enzymologic; Half-Life; Heme; Liver; Models, Biological; RNA, Messenger; Transcription, Genetic | 1991 |
Heme regulation in mouse mammary carcinoma and liver of tumor bearing mice--I. Effect of allyl-isopropylacetamide and veronal on delta-aminolevulinate synthetase, cytochrome P-450 and cytochrome oxidase.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Barbital; Cytochrome P-450 Enzyme System; Electron Transport Complex IV; Enzyme Induction; Heme; Liver; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C | 1990 |
L-Alanine: 4,5-dioxovalerate transaminase does not regulate heme synthesis in rat liver.
Topics: Alanine; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Chick Embryo; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Liver; Male; Phenobarbital; Porphyrins; Rats; Rats, Inbred Strains; Transaminases; Valerates | 1990 |
In vivo prevention and reversal by the antimitotic colchicine and other related compounds of some porphyrinogenic drug action on heme pathway.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Colchicine; Enzyme Induction; Griseofulvin; Heme; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Mice; Porphyrins; Vincristine | 1990 |
Regulation of heme synthesis in the regenerating rat liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarbethoxydihydrocollidine; Heme; Liver Regeneration; Male; Rats; Rats, Inbred Strains | 1990 |
Regulation of biogenesis of liver delta-aminolevulinate synthase: effects of structural modifications of heme on the enzyme's RNA.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Enzyme Induction; Heme; Hemin; Liver; Metalloporphyrins; RNA; Structure-Activity Relationship | 1989 |
Regulation of genes associated with drug metabolism.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Amino Acid Sequence; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Activation; Gene Expression Regulation; Heme; Humans; Inactivation, Metabolic; Liver; Molecular Sequence Data; Phenobarbital; Rats; RNA, Messenger; Transcription, Genetic; Transcriptional Activation | 1989 |
Synergistic effect of allyl isopropyl acetamide with cadmium on hepatic heme synthesis in chick embryo.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cadmium; Chick Embryo; Dose-Response Relationship, Drug; Drug Synergism; Heme; Liver; Porphobilinogen Synthase | 1989 |
Effect of haem on cytochrome P-450 synthesis.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation; Heme; Heptanoates; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; RNA, Messenger; Steroid 11-beta-Hydroxylase | 1989 |
Heme may not be a positive regulator of cytochrome-P450 gene expression.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Benzoflavones; beta-Naphthoflavone; Clofibrate; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Gene Expression Regulation; Genes; Heme; Humans; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Transcription, Genetic | 1989 |
Thyroid hormone regulation of heme synthesis in rat liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Heme; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Thyroidectomy; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse | 1988 |
Haem synthesis from exogenous 5-aminolaevulinate in cultured chick-embryo hepatocytes. Effects of inducers of cytochromes P-450.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Enzyme Induction; Heme; Levulinic Acids; Liver; Methylcholanthrene; Porphobilinogen; Porphyrins | 1987 |
Biogenesis of embryonic chick liver delta-aminolevulinate synthase: regulation of the level of mRNA by hemin.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; DNA; Heme; Hemin; Liver; Nucleic Acid Hybridization; Polyribosomes; Protein Biosynthesis; RNA, Messenger | 1987 |
The effects of haem arginate and haematin upon the allylisopropylacetamide induced experimental porphyria in rats.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Arginine; Heme; Hemin; Liver; Male; Porphobilinogen; Porphyrias; Rats; Rats, Inbred Strains | 1987 |
Regulation of cytochrome P-450 messenger RNA and apoprotein levels by heme.
Topics: Allylisopropylacetamide; Amitrole; Animals; Apoproteins; Cobalt; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Heme; Hemin; Male; Phenobarbital; Rats; RNA, Messenger | 1987 |
Inactivation of cytochrome P-450 by 2-isopropyl-4-pentenamide and other xenobiotics leads to heme-derived protein adducts.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme Inhibitors; Heme; Male; Microsomes, Liver; NADP; Porphyrins; Protein Binding; Proteins; Rats; Rats, Inbred Strains | 1986 |
Regulation of production of embryonic chick liver delta-aminolevulinate synthase: effects of testosterone and of hemin on the mRNA of the enzyme.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Dicarbethoxydihydrocollidine; Heme; Hemin; Liver; RNA, Messenger; Testosterone | 1986 |
Incorporation of haemoglobin haem into the rat hepatic haemoproteins tryptophan pyrrolase and cytochrome P-450.
Topics: Allylisopropylacetamide; Animals; Bile; Cytochrome P-450 Enzyme System; Heme; Hemoglobins; Liver; Male; Methemoglobin; Perfusion; Porphyrins; Rats; Rats, Inbred Strains; Tryptophan Oxygenase | 1986 |
Effect of age on rat liver heme and drug metabolism.
Topics: 5-Aminolevulinate Synthetase; Aging; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Heme Oxygenase (Decyclizing); Hemin; Liver; Microsomes, Liver; Oxygenases; Porphobilinogen Synthase; Rats; Rats, Inbred Strains | 1985 |
Carbon tetrachloride and 2-isopropyl-4-pentenamide-induced inactivation of cytochrome P-450 leads to heme-derived protein adducts.
Topics: Acetamides; Allylisopropylacetamide; Animals; Binding Sites; Carbon Tetrachloride; Cytochrome P-450 Enzyme Inhibitors; Electrophoresis; Heme; Immunochemistry; In Vitro Techniques; Male; Microsomes, Liver; Protein Binding; Proteins; Rats | 1986 |
Differential haemin-mediated restoration of cytochrome P-450 N-demethylases after inactivation by allylisopropylacetamide.
Topics: Acetamides; Allylisopropylacetamide; Animals; Chromatography, DEAE-Cellulose; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; Heme; Hemin; In Vitro Techniques; Isoenzymes; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Proteins; Rats; Rats, Inbred Strains | 1985 |
The influence of carbamazepine on the heme biosynthetic pathway.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Carbamazepine; Cells, Cultured; Chick Embryo; Drug Synergism; Heme; Hydroxymethylbilane Synthase; Liver; Porphobilinogen Synthase; Porphyrins; Proteins; Time Factors; Uroporphyrinogen Decarboxylase | 1985 |
Chemical porphyria in Japanese quail (Coturnix c. Japonica).
Topics: Allylisopropylacetamide; Animals; Bile; Biphenyl Compounds; Bromine; Coturnix; Dicarboxylic Acids; Environmental Pollution; Feedback; Female; Glutamate Dehydrogenase; Heme; Hexachlorocyclohexane; Kidney; Liver; Male; Mitochondria, Liver; Polychlorinated Biphenyls; Porphyrias; Porphyrins; Pyridines; Spectrometry, Fluorescence; Time Factors | 1973 |
Biochemical effects of 3,5-diethoxycarbonyl-1,4-dihydrocollidine in mouse liver.
Topics: Allylisopropylacetamide; Aniline Compounds; Animals; Carbon Radioisotopes; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Dicarboxylic Acids; Female; Heme; Iron Radioisotopes; Kinetics; Leucine; Lipid Metabolism; Liver; Mice; Microsomes, Liver; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Organ Size; Phenobarbital; Phospholipids; Protein Biosynthesis; Pyridines; Ribonucleases; RNA | 1974 |
Biochemical effects of the porphyrinogenic drug allylisopropylacetamide. A comparative study with phenobarbital.
Topics: Acetamides; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Female; Heme; Liver; Microsomes, Liver; Organ Size; Phenobarbital; Phospholipids; Proteins; Rats; Ribonucleases; RNA | 1973 |
Comparative study on induction of hepatic delta-aminolevulinate synthetase by different drugs.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Bucladesine; Cells, Cultured; Chick Embryo; Cycloheximide; Cytosol; Dicarboxylic Acids; Enzyme Induction; Heme; Liver; Mitochondria, Liver; Phenobarbital; Pyridines; Rats; Species Specificity; Time Factors | 1973 |
Antiporphyric effect exerted by caffeine administration in allylisopropylacetamide-treated rats.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Caffeine; Cytochrome P-450 Enzyme System; Female; Heme; Liver; Microsomes, Liver; Organ Size; Porphyrins; Proteins; Rats | 1974 |
Delta-aminolevulinic acid transport and synthesis, porphyrin synthesis and heme catabolism in chick embryo liver and heart cells.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Biological Transport; Carbon Radioisotopes; Chick Embryo; Chromatography, Ion Exchange; Coenzyme A Ligases; Dicarboxylic Acids; Enzyme Induction; Heart; Heme; Kinetics; Levulinic Acids; Liver; Myocardium; Organ Specificity; Oxygenases; Porphyrins; Pyridines; Regression Analysis; Rhodobacter sphaeroides; Succinates; Time Factors | 1974 |
The effects of drugs on the activities of 5-aminolaevulinate synthetase and other enzymes in the pathway of haem biosynthesis.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Dicarboxylic Acids; Esters; Griseofulvin; Heme; Liver; Mice; Phenobarbital; Phenylbutazone; Porphyrias; Pyridines; Rats | 1972 |
Studies on hepatic -aminolevulinic acid synthetase.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Carbon Isotopes; Citrates; Coenzyme A; Enzyme Induction; Freezing; Heme; Ketoglutaric Acids; Male; Membranes; Microsomes, Liver; Mitochondria, Liver; Picolines; Porphyrias; Rats; Subcellular Fractions; Succinates; Vibration | 1973 |
Evidence against a regulatory role for heme oxygenase in hepatic heme synthesis.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Microsomes, Liver; Oxygenases; Phenobarbital; Rats; Spleen; Starvation | 1973 |
Decreased liver activity of porphyrin-metal chelatase in hepatic porphyria caused by 3,5-diethoxycarbonyl-1,4-dihydrocollidine. Studies in rats and mice.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chemical and Drug Induced Liver Injury; Cycloheximide; Dicarboxylic Acids; Heme; Iron; Iron Radioisotopes; Levulinic Acids; Liver Diseases; Lyases; Male; Mice; Mitochondria, Liver; Porphyrias; Porphyrins; Proadifen; Pyridines; Rats; Species Specificity | 1973 |
A model for the regulation of delta-aminolaevulinate synthetase induction in rat liver.
Topics: 5-Aminolevulinate Synthetase; Adrenalectomy; Allylisopropylacetamide; Animals; Carbon Radioisotopes; Castration; Citrates; Cytochrome P-450 Enzyme System; Dactinomycin; Enzyme Induction; Female; Heme; Hydrocortisone; Iron Radioisotopes; Liver; Male; Microsomes, Liver; Models, Biological; Phenobarbital; Protein Binding; Rats | 1973 |
Transfer of hydrogen via tricarboxylic acid cycle activity to liver aspartate and glutamate in normal rats and to liver haem in normal and in allylisopropylacetamide-treated rats.
Topics: Acetamides; Allylisopropylacetamide; Animals; Aspartic Acid; Citric Acid Cycle; Ethanol; Female; Glutamates; Glycine; Heme; Hydrogen; Liver; Malates; Propionates; Rats; Succinates; Tritium | 1973 |
The role of certain 5beta-H-steroids in the regulation of porphyrin-heme formation.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cholesterol; Cyclohexanes; Female; Heme; Hypercholesterolemia; Mice; Mitochondria, Liver; Porphyrins; Pregnanes; Pyridines; Spectrophotometry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 1973 |
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.
Topics: Acetamides; Allylisopropylacetamide; Animals; Apoproteins; Cytochrome P-450 Enzyme System; Dicarboxylic Acids; Griseofulvin; Heme; Humans; Hydrocortisone; Levulinic Acids; Liver; Male; Mental Disorders; Microsomes; Phenobarbital; Phenylbutazone; Porphyrias; Proadifen; Protein Precursors; Pyridines; Rats; Starvation; Time Factors; Tryptophan; Tryptophan Oxygenase | 1973 |
Iron and the liver: acute effects of iron-loading on hepatic heme synthesis of rats. Role of decreased activity of 5-aminolevulinate dehydrase.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Dextrans; Drug Synergism; Heme; Iron; Liver; Male; Porphobilinogen Synthase; Protoporphyrins; Rats; Rats, Inbred Strains; Uroporphyrinogen Decarboxylase | 1983 |
Effect of glucose on the induction of delta-aminolevulinic acid synthase and ferrochelatase in isolated rat hepatocytes by allylisopropylacetamide.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Bucladesine; Carbohydrates; Cycloheximide; Enzyme Induction; Ferrochelatase; Gene Expression Regulation; Glucose; Heme; Liver; Lyases; Male; Rats | 1984 |
Tryptophan pyrrolase in haem regulation. The relationship between the depletion of rat liver tryptophan pyrrolase haem and the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Heme; Hexobarbital; Kinetics; Liver; Male; Methylphenazonium Methosulfate; Niacinamide; Rats; Tryptophan Oxygenase | 1980 |
Formation of cytochrome P-450 containing haem or cobalt-protoporphyrin in liver homogenates of rats treated with phenobarbital and allylisopropylacetamide.
Topics: Acetamides; Allylisopropylacetamide; Animals; Apoenzymes; Cytochrome P-450 Enzyme System; Heme; Immunoelectrophoresis; In Vitro Techniques; Liver; Male; Phenobarbital; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Spectrophotometry | 1984 |
Defective utilization of haem in selenium-deficient rat liver.
Topics: Allylisopropylacetamide; Animals; Heme; Liver; Male; Microsomes, Liver; Rats; Selenium; Tryptophan; Tryptophan Oxygenase | 1983 |
Translational inhibition by heme of the synthesis of hepatic delta-aminolevulinate synthase in a cell-free system.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cell-Free System; Heme; Kinetics; Liver; Male; Polyribosomes; Protein Biosynthesis; Rats; Rats, Inbred Strains | 1983 |
Effect of heme on allylisopropylacetamide-induced changes in heme and drug metabolism in the rhesus monkey (Macaca mulatta).
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Enzyme Activation; Ethylmorphine-N-Demethylase; Female; Heme; Heme Oxygenase (Decyclizing); Macaca mulatta; Microsomes, Liver; Porphyrias; Porphyrins | 1983 |
The allylisopropylacetamide and novonal prosthetic heme adducts.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Magnetic Resonance Spectroscopy; Phenobarbital; Rats; Structure-Activity Relationship | 1984 |
The effect in vivo and in vitro of allylisopropylacetamide on the content of hepatic microsomal cytochrome P-450 2 of phenobarbital treated rabbits.
Topics: Acetamides; Allylisopropylacetamide; Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Microsomes, Liver; NADP; Phenobarbital; Rabbits | 1983 |
Enzymatic formation of zinc-protoporphyrin by rat liver and its potential effect on hepatic heme metabolism.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Depression, Chemical; Enzyme Induction; Feedback; Ferrochelatase; Heme; Liver; Lyases; Male; Mitochondria, Liver; Porphyrins; Protoporphyrins; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1983 |
The effect of hemin and of allyl isopropyl acetamide on protein synthesis in rat hepatocytes.
Topics: Acetamides; Allylisopropylacetamide; Animals; Eukaryotic Initiation Factor-2; Heme; Liver; Male; Molecular Weight; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Polyribosomes; Protein Biosynthesis; Proteins; Rabbits; Rats; Rats, Inbred Strains; Reticulocytes; Tryptophan Oxygenase | 1983 |
Factors affecting haem degradation in rat brain.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Biotransformation; Brain; Female; Heme; Heme Oxygenase (Decyclizing); In Vitro Techniques; Lead; Liver; Phenobarbital; Rats | 1980 |
Control of delta-aminolaevulinate synthase and haem oxygenase in chronic-iron-overloaded rats.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cobalt; Heme; Heme Oxygenase (Decyclizing); Iron; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
Enhancement and inhibition of enzymes of heme metabolism by diethyl maleate in the rat kidney.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Ammonia-Lyases; Animals; Heme; Heme Oxygenase (Decyclizing); Hydroxymethylbilane Synthase; Kidney; Kinetics; Male; Maleates; Mixed Function Oxygenases; Porphobilinogen Synthase; Porphyrins; Rats; Rats, Inbred Strains | 1982 |
Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins.
Topics: Acetamides; Allylisopropylacetamide; Animals; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Heme; Liver; Pigments, Biological; Porphyrins; Rats; Secobarbital; Spectrophotometry | 1980 |
Evidence for the transcriptional inhibition by heme of the synthesis of delta-aminolevulinate synthase in rat liver.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Heme; Kinetics; Liver; Male; Polyribosomes; Rabbits; Rats; Rats, Inbred Strains; Reticulocytes; RNA, Messenger; Transcription, Genetic | 1982 |
Tryptophan pyrrolase in haem regulation. The mechanisms of enhancement of rat liver 5-aminolaevulinate synthase activity by starvation and of the glucose effect on induction of the enzyme by 2-allyl-2-isopropylacetamide.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Enzyme Induction; Fructose; Glucose; Heme; Hydrocortisone; Liver; Male; Rats; Rats, Inbred Strains; Starvation; Sucrose; Tryptophan Oxygenase | 1982 |
The effects of succinylacetone (4,6-dioxoheptanoic acid) on delta-aminolevulinate synthase activity and the content of heme in monolayers of chick embryo liver cells.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Drug Synergism; Enzyme Induction; Heme; Heptanoates; Heptanoic Acids; Levulinic Acids; Liver; Porphobilinogen Synthase | 1982 |
Cytochrome P-450 heme moiety. The specific target in drug-induced heme alkylation.
Topics: Alkylation; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Liver; Male; Norethindrone; Rats; Tryptophan Oxygenase | 1981 |
Heme enhances hexobarbital metabolism in perfused rat liver after drug-mediated destruction of cytochrome P-450.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; Hemeproteins; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats | 1981 |
Effects of porphyrinogenic (porphyria-producing) agents on avian embryonic hepatic glutathione S-transferase activity.
Topics: Acetamides; Allylisopropylacetamide; Animals; Chick Embryo; Cyproterone; Cytochrome P-450 Enzyme System; Cytosol; Glutathione Transferase; Heme; Liver; Phenobarbital; Porphyrias | 1981 |
Studies of the porphyrin-inducing activity of ethynyl compounds and conformationally restricted and unrestricted analogues of allylisopropylacetamide in chick embryo liver cell culture.
Topics: Acetamides; Alkynes; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Cytochrome P-450 Enzyme System; Heme; Liver; Molecular Conformation; Porphyrins | 1981 |
Regulation of synthesis and intracellular translocation of delta-aminolevulinate synthase by heme and its relation to the heme saturation of tryptophan pyrrolase in rat liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytosol; Heme; Hemin; Liver; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains; Tryptophan Oxygenase | 1981 |
Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Heme; Iron; Iron-Dextran Complex; Liver; Male; Rats; Time Factors | 1981 |
Translocation of delta-aminolevulinate synthase from the cytosol to the mitochondria and its regulation by hemin in the rat liver.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biological Transport; Cytosol; Enzyme Induction; Female; Heme; Kinetics; Liver; Mitochondria, Liver; Rats | 1980 |
Tryptophan pyrrolase in haem regulation. The mechanism of the permissive effect of cortisol on the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide in the adrenalectomized-rat liver.
Topics: 5-Aminolevulinate Synthetase; Adrenalectomy; Allopurinol; Allylisopropylacetamide; Animals; Heme; Hydrocortisone; Liver; Male; Rats; Tryptophan Oxygenase | 1980 |
Metabolism of hepatic haem and 'green pigments' in rats given 2-allyl-2-isopropylacetamide and ferric citrate. A new model for hepatic haem turnover.
Topics: Acetamides; Allylisopropylacetamide; Aminolevulinic Acid; Animals; Female; Ferric Compounds; Heme; Iron; Kinetics; Liver; Models, Biological; Organ Size; Pigments, Biological; Rats | 1980 |
Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
The influence of allyl isopropyl acetamide on d-aminolevulinic acid synthetase and cytochrome P-450.
Topics: 5-Aminolevulinate Synthetase; Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Heme; Liver; Male; Microsomes, Liver; Rats | 1980 |
Structural and functional reconstitution of hepatic cytochrome P-450 in vivo. Reversal of allylisopropylacetamide-mediated destruction of the hemoprotein by exogenous heme.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Ethylmorphine-N-Demethylase; Heme; Kinetics; Male; Microsomes, Liver; Phenobarbital; Rats | 1980 |
Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver.
Topics: Acetamides; Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Deferoxamine; Glutathione; Heme; Iron; Kinetics; Lipid Peroxides; Liver; Male; Microsomes, Liver; Porphyrins; Rats | 1980 |
Immunochemical studies of the turnover of delta-aminolevulinate synthase in rat liver mitochondria and the effect of hemin on it.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cycloheximide; Cytosol; Heme; Immune Sera; Immunoassay; Kinetics; Liver; Mitochondria, Liver; Rats | 1980 |
Haem control in experimental porphyria. The effect of haemin on the induction of delta-aminolaevulinate synthase in isolated chick-embryo liver cells.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Enzyme Induction; Heme; Hemin; In Vitro Techniques; Liver; Porphyrias | 1980 |
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Cytochrome P-450 Enzyme System; Deferoxamine; Dicarbethoxydihydrocollidine; Enzyme Induction; Heme; Hemin; Microsomes, Liver; Phenobarbital; Porphyrias; Proadifen | 1980 |
STZ-induced diabetes in mice and heme pathway enzymes. Effect of allylisopropylacetamide and alpha-tocopherol.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Heme; Male; Mice; Nucleoside Deaminases; Porphobilinogen Synthase; Porphyria, Acute Intermittent; Streptozocin; Thiosulfate Sulfurtransferase; Vitamin E | 1995 |
The influence of porphyrogenic drugs on the glyoxalase enzymes.
Topics: Allylisopropylacetamide; Barbiturates; Chloramphenicol; Diazepam; Erythrocytes; Heme; Hemoglobins; Humans; Kinetics; Lactoylglutathione Lyase; Oxytetracycline; Porphyrias; Protoporphyrins; Spectrophotometry, Ultraviolet; Sulfamethazine; Thiolester Hydrolases | 1993 |
Inactivation of phenobarbital-inducible rabbit-liver microsomal cytochrome P-450 by allylisopropylacetamide: impact on electron transfer.
Topics: Allylisopropylacetamide; Amino Acids; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes b5; Electron Transport; Enzyme Induction; Heme; Microsomes, Liver; NAD; NADP; Phenobarbital; Proteins; Rabbits | 1993 |
Hepatic 5-aminolevulinic acid synthase mRNA stability is modulated by inhibitors of heme biosynthesis and by metalloporphyrins.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Cells, Cultured; Chick Embryo; Dactinomycin; Deferoxamine; Enzyme Inhibitors; Glutethimide; Heme; Heptanoates; Kinetics; Liver; Metalloporphyrins; Porphobilinogen Synthase; Regression Analysis; RNA, Messenger | 1996 |
Drug metabolizing enzyme system and heme pathway in hepatocarcinogenesis.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Biotransformation; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Enzyme Induction; Enzyme Inhibitors; Glucuronidase; Glutathione Transferase; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Liver Neoplasms, Experimental; Male; Mice; Microsomes, Liver; Models, Biological; Oxidation-Reduction; p-Dimethylaminoazobenzene; Precancerous Conditions; Prodrugs; Sulfatases; Tryptophan Oxygenase | 1999 |
Relevance of cytochrome P450 levels in the actions of enflurane and isoflurane in mice: studies on the haem pathway.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Aminolevulinic Acid; Ammonia-Lyases; Anesthetics, Inhalation; Animals; Cytochrome P-450 Enzyme System; Enflurane; Heme; Heme Oxygenase (Decyclizing); Hydroxymethylbilane Synthase; Imidazoles; Isoflurane; Liver; Mice; Microsomes, Liver | 2000 |
Hemin-mediated restoration of allylisopropylacetamide-inactivated CYP2B1: a role for glutathione and GRP94 in the heme-protein assembly.
Topics: Allylisopropylacetamide; Animals; Antibodies; Benzoquinones; Cytochrome P-450 CYP2B1; Enzyme Inhibitors; Glutathione; Heme; Hemeproteins; HSP70 Heat-Shock Proteins; Kinetics; Lactams, Macrocyclic; Male; Membrane Proteins; Microsomes, Liver; Molecular Chaperones; Quinones; Rats; Rats, Sprague-Dawley | 2002 |
Response of glucose metabolism enzymes in an acute porphyria model. Role of reactive oxygen species.
Topics: Allylisopropylacetamide; Animals; Dicarbethoxydihydrocollidine; Disease Models, Animal; Female; Glucose; Heme; Lipid Peroxidation; Liver; Luminescent Measurements; Porphyria, Acute Intermittent; Rats; Rats, Wistar; Reactive Oxygen Species; Urine | 2005 |
The effect of haem biosynthesis inhibitors and inducers on intestinal iron absorption and liver haem biosynthetic enzyme activities.
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Antimicrobial Cationic Peptides; Duodenum; Enzyme Inhibitors; Heme; Hepcidins; Heptanoates; Intestinal Absorption; Iron Compounds; Male; Mice; Porphobilinogen; Porphobilinogen Synthase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
Alterations of the redox state, pentose pathway and glutathione metabolism in an acute porphyria model. Their impact on heme pathway.
Topics: Allylisopropylacetamide; Animals; Disease Models, Animal; Glucose; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Heme; Liver; NADP; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Porphyria, Acute Intermittent; Pyridines; Rats; Reactive Oxygen Species | 2013 |