heme has been researched along with acetylene in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| White, IN | 1 |
| Komives, EA; Ortiz de Montellano, PR | 1 |
| Correia, MA; Oritz de Montellano, PR | 1 |
| Beilan, HS; Kunze, KL; Mangold, BL; Ortiz de Montellano, PR; Wheeler, C | 1 |
| Alayrac, C; Durst, F; Helvig, C; Koop, D; Mioskowski, C; Poullain, D; Salaün, JP | 1 |
| Alworth, WL; Blobaum, AL; Hollenberg, PF; Kent, UM | 1 |
| Hollenberg, PF; Lin, HL; Noon, KR; Zhang, H | 1 |
| Hollenberg, PF; Jushchyshyn, M; Lin, HL; Zhang, H | 1 |
1 review(s) available for heme and acetylene
| Article | Year |
|---|---|
Suicidal destruction of cytochrome P-450 during oxidative drug metabolism.
Topics: Acetylene; Alkenes; Alkylation; Animals; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Heme; Humans; Isoenzymes; Liver; Oxidation-Reduction; Substrate Specificity | 1983 |
7 other study(ies) available for heme and acetylene
| Article | Year |
|---|---|
Metabolic activation of acetylenic substituents to derivatives in the rat causing the loss of hepatic cytochrome P-450 and haem.
Topics: Acetamides; Acetylene; Alkynes; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Danazol; Heme; Liver; Male; Microsomes, Liver; Pigments, Biological; Protein Binding; Rats | 1978 |
Branchpoint for heme alkylation and metabolite formation in the oxidation of arylacetylenes by cytochrome P-450.
Topics: Acetylene; Animals; Chemical Phenomena; Chemistry; Cytochrome P-450 Enzyme System; Heme; Kinetics; Microsomes, Liver; Oxygen; Phenobarbital; Phenylacetates; Rats | 1985 |
The cytochrome P-450 active site. Regiospecificity of prosthetic heme alkylation by olefins and acetylenes.
Topics: Acetylene; Alkenes; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Heme; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Structure-Activity Relationship | 1983 |
Suicide inactivation of cytochrome P450 by midchain and terminal acetylenes. A mechanistic study of inactivation of a plant lauric acid omega-hydroxylase.
Topics: Acetylene; Animals; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Heme; Lauric Acids; Microsomes; Mixed Function Oxygenases; Plant Proteins; Plants; Rabbits; Structure-Activity Relationship | 1997 |
Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.
Topics: Acetylene; Alkylation; Amino Acid Substitution; Animals; Apoproteins; Carbon Monoxide; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heme; Hydroxylation; Kinetics; NADP; Rabbits; Recombinant Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Substrate Specificity | 2002 |
Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein.
Topics: Acetylene; Alkynes; Amino Acid Substitution; Apoproteins; Catalytic Domain; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2B1; Enzyme Inhibitors; Ethers; Glutathione; Heme; Humans; Kinetics; Mass Spectrometry; Models, Molecular; Mutation; Oxygen; Protein Conformation; Solubility; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2009 |
Covalent modification of Thr302 in cytochrome P450 2B1 by the mechanism-based inactivator 4-tert-butylphenylacetylene.
Topics: Acetylene; Amino Acid Sequence; Capillary Electrochromatography; Catalytic Domain; Cytochrome P-450 CYP2B1; Databases, Protein; Escherichia coli; Heme; Hydrolysis; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Conformation; Recombinant Proteins; Spectrum Analysis; Threonine; Trypsin | 2010 |