heme has been researched along with 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole in 14 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (21.43) | 18.2507 |
2000's | 8 (57.14) | 29.6817 |
2010's | 3 (21.43) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Friebe, A; Koesling, D | 1 |
Behrends, S; Harteneck, C; Koesling, D; Russwurm, M | 1 |
Apeler, H; Becker, EM; Gerzer, R; Hoenicka, M; Schröder, H; Sirichoke, T; Stasch, JP | 1 |
Alonso-Alija, C; Apeler, H; Becker, EM; Dembowsky, K; Feurer, A; Gerzer, R; Minuth, T; Perzborn, E; Pleiss, U; Schramm, M; Schröder, H; Schroeder, W; Stahl, E; Stasch, JP; Steinke, W; Straub, A | 1 |
Lee, YC; Martin, E; Murad, F | 1 |
Counts Gerber, N; Kosarikov, DN; Lee, JM; Uversky, VN | 1 |
Behrends, S; Koglin, M | 1 |
Schmidt, P; Schramm, M; Schröder, H; Stasch, JP | 1 |
Kitagawa, T; Li, Z; Ohta, T; Pal, B; Takenaka, S; Tsuyama, S | 1 |
Czarnecki, K; Jayaraman, V; Kincaid, J; Martin, E; Murad, F | 1 |
Derbyshire, ER; Marletta, MA; Martin, NI | 1 |
Derbyshire, ER; Ibrahim, M; Marletta, MA; Spiro, TG | 1 |
Baskaran, P; Beuve, A; Heckler, EJ; van den Akker, F | 1 |
Campbell, E; David, CL; Fritz, BG; Gage, MJ; Garcin, ED; Hausrath, AC; Issaian, A; Montfort, WR; Purohit, R; Rassouli-Taylor, L; The, J; Weichsel, A | 1 |
14 other study(ies) available for heme and 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole
Article | Year |
---|---|
Mechanism of YC-1-induced activation of soluble guanylyl cyclase.
Topics: Animals; Binding Sites; Carbon Monoxide; Cattle; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Nitrogen Oxides; Photosensitizing Agents; Platelet Aggregation Inhibitors; Protoporphyrins; Solubility | 1998 |
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera | 1998 |
Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide.
Topics: Animals; Baculoviridae; Carbon Monoxide; Cell Line; Copper; Enzyme Activation; Guanylate Cyclase; Heme; Hydrazines; Indazoles; Mass Spectrometry; Nitric Oxide; Nitrogen Oxides; Recombinant Proteins; Spodoptera | 1999 |
NO-independent regulatory site on soluble guanylate cyclase.
Topics: Amino Acid Sequence; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cyclic N-Oxides; Cysteine; Disease Models, Animal; Enzyme Activation; Female; Guanylate Cyclase; Heme; Humans; Imidazoles; In Vitro Techniques; Indazoles; Molecular Sequence Data; Nitric Oxide; Photoaffinity Labels; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Rats; Solubility | 2001 |
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility | 2001 |
Role of conformational changes in the heme-dependent regulation of human soluble guanylate cyclase.
Topics: Acrylamide; Circular Dichroism; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Indazoles; Models, Chemical; Models, Molecular; Nitric Oxide; Nitric Oxide Donors; Protein Conformation; Protein Structure, Secondary; Spectrometry, Fluorescence; Tryptophan | 2001 |
A functional domain of the alpha1 subunit of soluble guanylyl cyclase is necessary for activation of the enzyme by nitric oxide and YC-1 but is not involved in heme binding.
Topics: Animals; Cattle; Cell Line; Cloning, Molecular; Enzyme Activation; Enzyme Activators; Gene Deletion; Guanylate Cyclase; Heme; Humans; Indazoles; Nitric Oxide; Protein Binding; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Spodoptera | 2003 |
Preparation of heme-free soluble guanylate cyclase.
Topics: Benzoates; Chromatography, Ion Exchange; Cyclic GMP; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Indazoles; Nitroprusside; Polysorbates; Proteins; Protoporphyrins; Spectrophotometry; Zinc | 2003 |
Resonance Raman study on synergistic activation of soluble guanylate cyclase by imidazole, YC-1 and GTP.
Topics: Animals; Cattle; Drug Synergism; Enzyme Activation; Guanosine Triphosphate; Guanylate Cyclase; Heme; Imidazoles; In Vitro Techniques; Indazoles; Solubility; Spectrum Analysis, Raman | 2004 |
Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase.
Topics: Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Protein Conformation; Pyrazoles; Pyridines; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Structure-Activity Relationship | 2005 |
Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1.
Topics: Alcohols; Chemistry, Pharmaceutical; Drug Design; Electrons; Enzyme Activation; Enzyme Activators; Guanosine Triphosphate; Guanylate Cyclase; Heme; Indazoles; Kinetics; Models, Chemical; Nitric Oxide; Organophosphonates; Phosphorylation; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Temperature | 2007 |
Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy.
Topics: Animals; Binding Sites; Carbon Monoxide; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Kinetics; Protein Binding; Protein Structure, Tertiary; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spectrum Analysis, Raman | 2010 |
Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.
Topics: Alanine; Animals; Aspartic Acid; Chlorocebus aethiops; COS Cells; Enzyme Activation; Guanylate Cyclase; Heme; Indazoles; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Nitric Oxide; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Soluble Guanylyl Cyclase | 2011 |
YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit.
Topics: Allosteric Regulation; Animals; Carbon Monoxide; Cattle; Guanylate Cyclase; Heme; Indazoles; Manduca; Models, Molecular; Nitric Oxide; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Subunits; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Surface Plasmon Resonance | 2014 |