helenalin has been researched along with sesquiterpenes in 109 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (26.61) | 18.7374 |
| 1990's | 13 (11.93) | 18.2507 |
| 2000's | 37 (33.94) | 29.6817 |
| 2010's | 30 (27.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ElGebaly, SA; HADGRAFT, RI; Hall, IH; Lee, KH; Mar, EC; Ruffner, CG; Starnes, CO; Waddell, TG; Weidner, I | 1 |
| Hall, IH; Haruna, M; Huang, HC; Lee, KH; Wu, BS | 1 |
| Eigebaly, SA; Hall, IH; Lee, KH | 1 |
| Hall, IH; Ibuka, T; Lee, KH; Mar, EC | 1 |
| Hall, IH; Lee, KH; Mar, EC; Okamoto, M | 1 |
| Hall, IH; Lee, KH; Mar, EC; Starnes, CO; Waddell, TG | 1 |
| Dollahite, JW; Ivie, W; Witzel, DA | 1 |
| Grippo, AA; Hall, IH; Kiyokawa, H; Lee, KH; Muraoka, O; Shen, YC | 1 |
| Chaney, SG; Chapman, DE; Hall, IH; Holbrook, DJ; Lee, KH | 2 |
| Leven, W; Lösche, W; Schröder, H; Schrör, K; Strobach, H; Till, U; Willuhn, G | 1 |
| Chaney, SG; Chang, JJ; Grippo, AA; Hall, IH; Holbrook, DJ; Lee, KH; Yang, LM | 1 |
| Furukawa, H; Ito, K; Itoigawa, M; Takeya, K | 1 |
| Gaspar, AR; Neitz, AW; Vermeulen, NM; Verschoor, JA | 1 |
| Grippo, AA; Hall, IH; Holbrook, DJ; Kim, HL; Lee, KH; Lin, HC; Roberts, G | 1 |
| Chaney, SG; Gilbert, CJ; Hall, IH; Holbrook, DJ; Kiyokawa, H; Lee, KH; Muraoka, O; Williams, WL | 1 |
| Chaney, SG; Grippo, AA; Hall, IH; Holbrook, DJ; Lee, KH; Oswald, CB; Williams, WL | 1 |
| Chaney, SG; Grippo, AA; Hall, IH; Holbrook, DJ; Lee, KH | 1 |
| Hayes, MA; Kim, HL; Merrill, JC; Murray, CA; Safe, S | 1 |
| Chaney, SG; Chang, J; Chapman, DE; Grippo, AA; Hall, IH; Holbrook, DJ; Lee, KH; Reynolds, DJ; Roberts, GB | 1 |
| Hall, IH; Lee, KH; Sykes, HC | 1 |
| Cohen, GM; d'Arcy Doherty, M; Jordan, J | 1 |
| Anderson, AC; Kim, HL | 1 |
| Kim, HL; Merrill, J; Safe, S | 1 |
| Elissalde, MH; Ivie, GW | 1 |
| Chaney, SG; Hall, IH; Lee, KH; Williams, WL | 1 |
| Elissalde, GS; Elissalde, MH; Ivie, GW; Rowe, LD | 1 |
| Furukawa, H; Itoigawa, M; Takeya, K | 1 |
| Donnelly, KC; Jones, DH; Kim, HL | 1 |
| Chaney, SG; Hall, IH; Lee, KH; Liou, YF; Williams, WL | 1 |
| Chaney, SG; Considine, RT; Hall, IH; Lee, KH; Williams, WL; Willingham, W | 1 |
| Hausen, BM | 1 |
| Hall, IH; Ibuka, T; Imakura, Y; Lee, KH; Liou, YF; Okano, M; Sims, D | 1 |
| Calzada, L; Salazar Esquivel, EL; Tellez, MC | 1 |
| Abraham, RT; Ashendel, CL; Bonjouklian, R; Gallegos, A; Grindey, GB; Powis, G; Zalkow, LH | 1 |
| Enriz, RD; Giordano, OS; Guzmán, J; Jáuregui, EA; Pestchanker, MJ; Rodriguez, AM | 1 |
| Schmidt, TJ | 2 |
| Schaffner, W | 1 |
| Lyss, G; Merfort, I; Pahl, HL; Schmidt, TJ | 2 |
| Knorre, A; Lyss, G; Merfort, I; Pahl, HL; Schmidt, TJ | 1 |
| Konwalinka, G; Stuppner, H; Tiefenthaler, M; Zidorn, C | 1 |
| Dirsch, VM; Stuppner, H; Vollmar, AM | 1 |
| Heilmann, J; Schmidt, TJ; Wasescha, MR | 1 |
| Ericsson, I; Näsman-Glaser, B; Schmidt, TJ; Tornhamre, S | 1 |
| Brun, R; Khalid, SA; Schmidt, TJ; Willuhn, G | 1 |
| Chiarugi, A | 1 |
| Huuskonen, J; Kyrylenko, S; Pihlaja, R; Salminen, A; Suuronen, T | 1 |
| Gertsch, J; Heilmann, J; Schmidt, T; Sticher, O | 1 |
| François, G; Passreiter, CM | 1 |
| Hsieh, HL; Jou, MJ; Yang, CM; Yen, MH | 1 |
| Chien, CS; Lin, CC; Lin, FS; Luo, SF; Yang, CM | 1 |
| Kim, SH; Kim, TS; Oh, SM | 1 |
| Brengio, SD; Burgos, MH; Giordano, O; Jimenez-Ortiz, V; Sánchez, M; Sosa, MA; Tonn, C | 1 |
| Hsieh, HL; Hwang, TL; Parker, P; Wu, CY; Yang, CM; Yen, MH | 1 |
| Chung, LW; Jin, F; Khuri, FR; Liu, X; Lotan, R; Sun, SY; Yue, P; Zhou, Z | 1 |
| Huang, PR; Wang, TC; Yeh, YM | 1 |
| Lee, CW; Lin, CC; Lin, WN; Luo, SF; Pouyssegur, J; Wang, JS; Yang, CM | 1 |
| Harder, J; Schröder, JM; Stange, EF; Voss, E; Wehkamp, J; Wehkamp, K | 1 |
| Andreadi, CK; Atherfold, PA; Howells, LM; Manson, MM | 1 |
| Bergonzi, MC; Bilia, AR; Mazzi, G; Vincieri, FF | 1 |
| Jiang, S; Kwong, JM; Lam, TT; Sadun, AA; Sanchez, RN; Wang, J | 1 |
| Grdina, DJ; Kataoka, Y; Murley, JS; Oberley, LW; Weydert, CJ | 1 |
| Kitaoka, Y; Kwong, JM; Lam, TT; Ross-Cisneros, FN; Sadun, AA; Tsai, RK; Wang, J | 1 |
| Doody, GM; Stephenson, S; Tooze, RM | 1 |
| Auld, CA; Fernandes, KM; Hopkins, RG; Morrison, RF | 2 |
| Söder, O; Supornsilchai, V; Svechnikov, K | 1 |
| Merfort, I; Wagner, S | 1 |
| Boulanger, D; Brouillette, E; Bureau, F; Jaspar, F; Lekeux, P; Mainil, J; Malouin, F | 1 |
| Faurschou, A; Gniadecki, R; Lisby, S | 1 |
| Bergamante, V; Ceschel, GC; Fini, A; Marazzita, S; Ronchi, C | 1 |
| Barrera, PA; Galanti, N; Giordano, O; Jimenez-Ortiz, V; Sosa, MA; Tonn, C | 1 |
| Burgess, EJ; Joyce, NI; Littlejohn, RP; López Mosquera, E; Perry, NB; Rodríguez Guitián, MA; Romero Franco, R; Smallfield, BM | 1 |
| Cheng, SE; Hsieh, HL; Jou, MJ; Kou, YR; Lee, IT; Lin, CC; Luo, SF; Yang, CM | 1 |
| Hughes, JM; Merfort, I; Oliver, BG; Roth, M; Seidel, P; Tamm, M | 1 |
| Kamiya, T; Kunimatsu, R; Nakatani, Y; Tanaka, E; Tanaka, N; Tanimoto, K; Tanne, K; Tanne, Y | 1 |
| Berges, C; Daniel, V; Fuchs, D; Naujokat, C; Opelz, G | 1 |
| Büchele, B; Lunov, O; Merfort, I; Simmet, T; Syrovets, T; Zugmaier, W | 1 |
| Denkova, P; Evstatieva, L; Staneva, J; Todorova, M | 1 |
| Cho, BJ; Kim, CJ; Kim, SJ; Lee, JY; Park, BE; Park, TW; Sim, SS | 1 |
| Lee, CW; Lee, HC; Lee, IT; Lin, CC; Yang, CM | 1 |
| Dholakia, S; Elkington, PT; Friedland, JS; Fry, J; Green, JA; Janczar, K; Moores, R; Ong, CW; Roncaroli, F | 1 |
| Dirsch, VM; Hoffmann, R; López-Antón, N; Rudy, A; Vollmar, AM; von Schwarzenberg, K; Wanner, G | 1 |
| Chung, HY; Jiang, RW; Li, J; Li, YL; Su, MX; Wang, GC; Wang, Y; Wu, P; Ye, WC | 1 |
| Feng, X; Fu, PY; Hamza, MS; Ky, N; Li, J; Lim, CB; Srinivasan, KG; Zhao, Y; Zhu, HS | 1 |
| Al-Alwan, L; Baglole, CJ; Chang, Y; Eidelman, DH; Halayko, AJ; Hamid, Q; Martin, JG; Risse, PA | 1 |
| Iqbal, T; Jang, JH; Kim, S; Kwon, TK; Lee, TJ; Min, KJ; Park, JW; Son, EI | 1 |
| Gorbacheva, L; Ishiwata, S; Pinelis, V; Reiser, G; Stricker, R; Strukova, S | 1 |
| Chen, S; Huang, L; Huang, S; Peng, J; Xu, A; Yuan, S; Zhang, J; Zhang, L | 1 |
| Abdul, Y; Akhter, N; Husain, S; Nix, M; Singh, S | 1 |
| Shin, HJ; Youn, HS | 1 |
| Abbasi, M; Akbarzadeh, A; Alizadeh, E; Barkhordari, A; Ghasemali, S; Kordi, S; Nejati-Koshki, K; Rahmati-Yamchi, M; Tafsiri, E; Tozihi, M; Zarghami, N | 1 |
| Cho, KM; Hwang, SY; Kim, HJ; Kim, SH; Kim, TS; Song, JH | 1 |
| Huang, Q; Huang, R; Liang, S; Lin, X; Lu, Z; Tan, S; Tian, Y; Wei, L; Wu, X; Zhang, S | 1 |
| Cheung, HY; Xu, L; Zhang, Z | 1 |
| Galanti, N; Jimenez, V; Kemmerling, U; Maya, JD; Paredes, R; Sosa, MA | 1 |
| Duan, M; Fan, J; Gao, Q; Liu, LZ; Shi, JY; Song, FN; Wang, XY; Wang, ZC; Yang, LX; Zhou, J | 1 |
| Akbarzadeh, A; Barkhordari, A; Ghasemali, S; Kordi, S; Rahmati, YM; Tozihi, M; Zarghami, N | 1 |
| Berdel, WE; Coulibaly, A; Jakobs, A; Klempnauer, KH; Müller-Tidow, C; Schlenke, P; Schmidt, TJ; Schomburg, C; Steinmann, S; Uttarkar, S | 1 |
| Hu, H; Li, Y; Li, Z; Yang, B; Zhang, S | 1 |
| Henrich, SM; Jakobs, A; Klempnauer, KH; Schmidt, TJ; Steinmann, S | 1 |
| Albrecht, D; Haertel, B; Lalk, M; Lindequist, U; Methling, K; Niehs, S; Schultze, N; Wachlin, G; Wurster, M; Zwicker, P | 1 |
| Harki, DA; Kempema, AM; Villalta, PW; Widen, JC | 1 |
| Borborema, SET; Costa-Silva, TA; Da Costa, FB; Galuppo, MK; Lima, ML; Mesquita, JT; Schmidt, TJ; Taniwaki, NN; Tempone, AG; Wulsten, IF | 1 |
| Baur, JW; Brown, DA; Brown, TJ; Edwards, JT; Harki, DA; Kempema, AM; Meece, FA; Skopec, HM; Widen, JC | 1 |
| Chen, CJ; Chen, LK; Hong, YR; Jan, RH; Lin, YL | 1 |
| Beer, MF; Bivona, AE; Cerny, N; Donadel, OJ; Malchiodi, EL; Martín, VS; Padrón, JM; Reta, GF; Sánchez Alberti, A; Sülsen, VP | 1 |
1 review(s) available for helenalin and sesquiterpenes
| Article | Year |
|---|---|
[Arnica allergy].
Topics: Adult; Aged; Animals; Chemical Phenomena; Chemistry; Child; Cross Reactions; Dermatitis, Contact; Female; Guinea Pigs; Humans; Lactones; Methacrylates; Middle Aged; Plant Extracts; Plants, Medicinal; Self Medication; Sesquiterpenes; Sesquiterpenes, Guaiane | 1980 |
1 trial(s) available for helenalin and sesquiterpenes
| Article | Year |
|---|---|
Development and stability of semisolid preparations based on a supercritical CO2 Arnica extract.
Topics: Administration, Cutaneous; Adult; Arnica; Cetomacrogol; Chromatography, Supercritical Fluid; Drug Stability; Emulsions; Excipients; Female; Humans; Permeability; Plant Extracts; Polysorbates; Sesquiterpenes; Sesquiterpenes, Guaiane; Skin Absorption; Surface-Active Agents | 2006 |
107 other study(ies) available for helenalin and sesquiterpenes
| Article | Year |
|---|---|
Sesquiterpene antitumor agents: inhibitors of cellular metabolism.
Topics: Alkylation; Animals; Antimetabolites, Antineoplastic; Carcinoma, Ehrlich Tumor; Cholesterol; Cyclic AMP; Cysteine; DNA, Neoplasm; Glycolysis; Lactones; Male; Nucleic Acid Synthesis Inhibitors; Oxygen Consumption; Rats; RNA, Neoplasm; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship; Sulfhydryl Compounds | 1977 |
Antitumor agents XXIII: Helenalin, and antitumor principle from Anaphalis morrisonicola HAY.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chemical Phenomena; Chemistry; Leukemia, Experimental; Phytotherapy; Plants, Medicinal; Sesquiterpenes; Sesquiterpenes, Guaiane | 1977 |
Antitumor agents XXVII: Effects of helenalin on anaerobic and aerobic metabolism of Ehrlich ascites cells.
Topics: Aerobiosis; Anaerobiosis; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Ehrlich Tumor; In Vitro Techniques; Male; Mice; Oxygen Consumption; Sesquiterpenes; Sesquiterpenes, Guaiane | 1978 |
Antitumor agents. 31. Helenalin sym-dimethylethylenediamine reaction products and related derivatives.
Topics: Alkylating Agents; Animals; Carcinoma 256, Walker; Cells, Cultured; Chemical Phenomena; Chemistry; Ethylenediamines; Lactams; Leukemia, Experimental; Male; Mice; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane | 1978 |
Antitumor agents 32. Synthesis and antitumor activity of cyclopentenone derivatives related to helenalin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma 256, Walker; Cells, Cultured; Cyclopentanes; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mice; Mice, Inbred DBA; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane | 1978 |
Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones.
Topics: Animals; Antineoplastic Agents, Phytogenic; Ascitic Fluid; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chromatin; Cyclopentanes; Cysteine; DNA, Neoplasm; Glutathione; Histidine; Lactones; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mice; Mice, Inbred DBA; Neoplasm Proteins; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane; Spectrophotometry, Ultraviolet; Time Factors | 1977 |
Mammalian toxicity of helenalin, the toxic principle of Helenium microcephalum CD (smallhead sneezeweed).
Topics: Animals; Cricetinae; Lactones; Mice; Plant Extracts; Plants, Toxic; Rabbits; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane; Sheep; Sheep Diseases | 1976 |
The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones in murine and human tumor cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Deoxyribonucleotides; DNA-Directed DNA Polymerase; Esters; Humans; Lactones; Leukemia L1210; Mice; Ribonucleotides; Sesquiterpenes; Sesquiterpenes, Guaiane; Tumor Cells, Cultured | 1992 |
In vivo and in vitro effects of helenalin on mouse hepatic microsomal cytochrome P450.
Topics: Animals; Cytochrome P-450 Enzyme System; Heme; Lipid Peroxidation; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxygen Consumption; Sesquiterpenes; Sesquiterpenes, Guaiane | 1991 |
Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways.
Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cysteine; Humans; Phospholipases A; Phospholipases A2; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfhydryl Reagents; Thromboxane B2 | 1990 |
Renal, hepatic, cardiac and thymic acute toxicity afforded by bis(helenalinyl)malonate in BDF1 mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Body Weight; Dose-Response Relationship, Drug; Heart; Injections, Intraperitoneal; Kidney; Lethal Dose 50; Liver; Male; Mice; Organ Size; Sesquiterpenes; Sesquiterpenes, Guaiane; Terpenes; Thymus Gland | 1990 |
Mode of cardiotonic action of helenalin, a sesquiterpene lactone, on guinea pig ventricular myocardium.
Topics: Action Potentials; Animals; Cardiotonic Agents; Cyclic AMP; Drug Interactions; Female; Guinea Pigs; Male; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Sesquiterpenes; Sesquiterpenes, Guaiane | 1987 |
The influence of the sesquiterpene lactones from Geigeria on mast cell degranulation.
Topics: Alkylation; Animals; Cysteine; Ethylmaleimide; Histamine Release; Lactones; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Plant Extracts; Rats; Rats, Inbred Strains; Sesquiterpenes; Sesquiterpenes, Guaiane; Thapsigargin | 1987 |
In vitro inhibition of mouse hepatic mixed-function oxidase enzymes by helenalin and alantolactone.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethylmaleimide; Glutathione; Lactones; Liver; Male; Mice; NADP; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Sesquiterpenes; Sesquiterpenes, Eudesmane; Sesquiterpenes, Guaiane; Toxins, Biological | 1989 |
Role of thiol agents in protecting against the toxicity of helenalin in tumor-bearing mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Free Radicals; Glutathione; Hydrogen-Ion Concentration; Leukemia P388; Male; Mice; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfhydryl Compounds | 1989 |
Antitumor agents 68: effects of a series of helenalin derivatives on P-388 lymphocytic leukemia nucleic acid and protein synthesis.
Topics: Animals; Antineoplastic Agents, Phytogenic; DNA, Neoplasm; IMP Dehydrogenase; Leukemia P388; Leukemia, Experimental; Mice; Neoplasm Proteins; Nucleic Acid Synthesis Inhibitors; Purines; RNA, Neoplasm; Sesquiterpenes; Sesquiterpenes, Guaiane; Time Factors | 1985 |
Inhibition of nucleic acid synthesis in P-388 lymphocytic leukemia tumor cells by helenalin and bis(helenalinyl)malonate in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; DNA, Neoplasm; IMP Dehydrogenase; In Vitro Techniques; Leukemia P388; Leukemia, Experimental; Male; Mice; Neoplasm Proteins; RNA, Neoplasm; Sesquiterpenes; Sesquiterpenes, Guaiane; Terpenes; Thioredoxins | 1988 |
Effect of helenalin and bis(helenalinyl)malonate on nucleic acid and protein synthesis in human KB carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; DNA, Neoplasm; Glutaredoxins; Humans; IMP Dehydrogenase; KB Cells; Neoplasm Proteins; Oxidoreductases; Proteins; Purines; Ribonucleoside Diphosphate Reductase; RNA, Neoplasm; Sesquiterpenes; Sesquiterpenes, Guaiane; Terpenes; Thioredoxins; Thymidylate Synthase | 1987 |
Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin.
Topics: Acetylcysteine; Animals; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Sesquiterpenes; Sesquiterpenes, Guaiane; Thiazoles; Thiazolidines; Toxins, Biological | 1988 |
Acute toxicity of helenalin in BDF1 mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Enzymes; Lethal Dose 50; Male; Maleates; Mice; Mice, Inbred Strains; Microsomes, Liver; Organ Size; Sesquiterpenes; Sesquiterpenes, Guaiane | 1988 |
Anti-inflammatory agents; IV. Structure activity relationships of sesquiterpene lactone esters derived from helenalin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Esters; Lactones; Male; Mice; Rats; Rats, Inbred Strains; Sesquiterpenes; Sesquiterpenes, Guaiane | 1987 |
Effects of glutathione depletion on the cytotoxicity of agents toward a human colonic tumour cell line.
Topics: Antimetabolites; Antineoplastic Agents, Phytogenic; Buthionine Sulfoximine; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Glutathione; Humans; Melphalan; Methionine Sulfoximine; Naphthols; Naphthoquinones; Sesquiterpenes; Sesquiterpenes, Guaiane; Vitamin K | 1987 |
Depletion and resynthesis of tissue thiols by helenalin and tenulin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Female; Glutathione; Mice; Mice, Inbred ICR; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfhydryl Compounds; Time Factors | 1986 |
Helenalin: mechanism of toxic action.
Topics: Animals; Drug Interactions; Glutathione; Liver; Male; Mice; Mice, Inbred ICR; Pyrrolidonecarboxylic Acid; Sesquiterpenes; Sesquiterpenes, Guaiane; Thiazoles; Thiazolidines; Toxins, Biological | 1986 |
Inhibition of macrophage adenylate cyclase by the alpha-methylene-gamma-lactone moiety of sesquiterpene lactones from forage plants.
Topics: Adenylyl Cyclase Inhibitors; Animal Feed; Animals; In Vitro Techniques; Lactones; Macrophages; Plants, Toxic; Sesquiterpenes; Sesquiterpenes, Guaiane | 1987 |
Indirect inactivation of rabbit reticulocyte initiation factor eIF-2 by helenalin and bis(helenalinyl) malonate.
Topics: Animals; Cyclic AMP; eIF-2 Kinase; Enzyme Activation; Eukaryotic Initiation Factor-2; Kinetics; Peptide Biosynthesis; Peptide Chain Initiation, Translational; Peptide Initiation Factors; Peptides; Protein Biosynthesis; Protein Kinases; Proteins; Rabbits; Reticulocytes; Sesquiterpenes; Sesquiterpenes, Guaiane; Terpenes | 1984 |
Considerations of the structure of sesquiterpene lactones on biological activity: influence of the alpha-methylene-gamma-lactone moiety on mast cell degranulation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Ascitic Fluid; Calcium; Cells, Cultured; Chemical Phenomena; Chemistry; Cyclic AMP; Cytoplasmic Granules; Histamine Release; Lactones; Mast Cells; Mutagens; Rats; Rats, Inbred Strains; Sesquiterpenes; Sesquiterpenes, Guaiane; Toxins, Biological | 1983 |
Positive inotropic effect of helenalin, a sesquiterpene lactone, on guinea-pig myocardium.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Myocardial Contraction; Sesquiterpenes; Sesquiterpenes, Guaiane | 1983 |
DNA damaging effects of three sesquiterpene lactones in repair-deficient mutants of Bacillus subtilis.
Topics: Bacillus subtilis; DNA Repair; DNA, Bacterial; Mutation; Sesquiterpenes; Sesquiterpenes, Guaiane | 1981 |
Investigation of sesquiterpene lactones as protein synthesis inhibitors of P-388 lymphocytic leukemia cells.
Topics: Animals; Antineoplastic Agents; Kinetics; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred DBA; Neoplasm Proteins; Poly U; Protein Biosynthesis; Sesquiterpenes; Sesquiterpenes, Guaiane; Terpenes | 1983 |
Selective inactivation of rabbit reticulocyte initiation factor eIF-3 by helenalin.
Topics: Animals; Ethylmaleimide; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-3; Eukaryotic Initiation Factors; Glutathione; Peptide Initiation Factors; Proteins; Rabbits; Reticulocytes; Sesquiterpenes; Sesquiterpenes, Guaiane | 1983 |
Antitumor agents XLII: Comparison of antileukemic activity of helenalin, brusatol, and bruceantin and their esters on different strains of P-388 lymphocytic leukemic cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cells, Cultured; DNA, Neoplasm; Glaucarubin; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Neoplasm Proteins; Phenanthrenes; Quassins; Sesquiterpenes; Sesquiterpenes, Guaiane; Thymidine | 1981 |
[Reductive effect of the sesquiterpenic lactone "Helenalin " and its metallic derivatives in the formation of the estradiol receptor complex in breast tumor tissue].
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Carcinoma, Ductal, Breast; Humans; Organometallic Compounds; Receptors, Estradiol; Sesquiterpenes; Sesquiterpenes, Guaiane; Tumor Cells, Cultured | 1995 |
Increased intracellular Ca2+ signaling caused by the antitumor agent helenalin and its analogues.
Topics: 3T3 Cells; Animals; Antineoplastic Agents, Phytogenic; Calcium; Mice; Protein Kinase C; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction | 1994 |
Structure-activity relationship in the cytoprotective effect of helenalin and related compounds.
Topics: Cardiotonic Agents; Gastric Mucosa; Lactones; Molecular Conformation; Platelet Aggregation Inhibitors; Sesquiterpenes; Sesquiterpenes, Guaiane; Stereoisomerism; Structure-Activity Relationship | 1994 |
Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules.
Topics: Antineoplastic Agents, Phytogenic; Binding, Competitive; Cysteine; Glutathione; Magnetic Resonance Spectroscopy; Models, Molecular; Sesquiterpenes; Sesquiterpenes, Guaiane; Stereoisomerism; Structure-Activity Relationship; Toxins, Biological | 1997 |
Granny's remedy explained at the molecular level: helenalin inhibits NF-kappaB.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arnica; Cardiotonic Agents; Digitalis; Humans; Medicine, Traditional; NF-kappa B; Phytotherapy; Plant Extracts; Plants, Medicinal; Plants, Toxic; Sesquiterpenes; Sesquiterpenes, Guaiane | 1997 |
Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Arnica; B-Lymphocytes; Blotting, Western; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; HeLa Cells; Humans; I-kappa B Proteins; Jurkat Cells; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Plant Extracts; Plants, Medicinal; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship; T-Lymphocytes; Transfection | 1997 |
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Nucleus; Dimerization; Humans; Jurkat Cells; NF-kappa B; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship; Transcription Factor RelA | 1998 |
Cytotoxic activities of hypocretenolides from Leontodon hispidus.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Bone Marrow Cells; Colony-Forming Units Assay; Coloring Agents; Drug Screening Assays, Antitumor; Erythropoiesis; Female; Humans; Male; Plants, Medicinal; Sesquiterpenes; Sesquiterpenes, Guaiane; Stem Cells; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1999 |
Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions.
Topics: Binding Sites; Cysteine; Glutathione; Hydrogen-Ion Concentration; Kinetics; Lactones; Magnetic Resonance Spectroscopy; Models, Chemical; NF-kappa B; Sesquiterpenes; Sesquiterpenes, Guaiane; Spectrophotometry, Ultraviolet | 1999 |
Glutathione adducts of helenalin and 11 alpha,13-dihydrohelenalin acetate inhibit glutathione S-transferase from horse liver.
Topics: Animals; Enzyme Inhibitors; Glutathione; Glutathione Transferase; Horses; Liver; Sesquiterpenes; Sesquiterpenes, Guaiane | 2000 |
Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x(L) or Bcl-2.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-X Protein; Caspase 3; Caspase 8; Caspase 9; Caspases; Enzyme Activation; Enzyme Induction; Fas Ligand Protein; fas Receptor; Humans; Jurkat Cells; Matrix Metalloproteinases; Membrane Glycoproteins; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Sesquiterpenes, Guaiane | 2001 |
The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Survival; Cysteine; Drug Interactions; Glutathione; Humans; KB Cells; Lactones; Sesquiterpenes; Sesquiterpenes, Guaiane; Tumor Cells, Cultured | 2001 |
Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C(4) synthase in human blood cells.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Blood Platelets; Calcimycin; Drug Interactions; Glutathione Transferase; Granulocytes; Humans; Ionophores; Leukotriene A4; Leukotriene C4; Lipoxygenase Inhibitors; Platelet Aggregation Inhibitors; Sesquiterpenes; Sesquiterpenes, Guaiane | 2001 |
Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones.
Topics: Animals; Arnica; Inhibitory Concentration 50; Lactones; Molecular Structure; Plants, Medicinal; Sesquiterpenes; Sesquiterpenes, Guaiane; Trypanocidal Agents; Trypanosoma cruzi | 2002 |
Characterization of the molecular events following impairment of NF-kappaB-driven transcription in neurons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Caspases; Cells, Cultured; Cerebral Cortex; Cytochrome c Group; DNA; DNA-Binding Proteins; Homeostasis; Mitochondria; Neurons; NF-kappa B; Nitriles; Organic Chemicals; Peptides; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Precursors; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Replication Protein C; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfones; Transcription, Genetic | 2002 |
Regulation of microglial inflammatory response by histone deacetylase inhibitors.
Topics: Animals; Caffeic Acids; Cells, Cultured; Coculture Techniques; DNA; Drug Synergism; Enzyme Inhibitors; Hippocampus; Histone Deacetylase Inhibitors; Inflammation; Interleukin-6; Lipopolysaccharides; Mice; Microglia; Neurons; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenylethyl Alcohol; Rats; Rats, Wistar; RNA, Messenger; Sesquiterpenes; Sesquiterpenes, Guaiane | 2003 |
Influence of helenanolide-type sesquiterpene lactones on gene transcription profiles in Jurkat T cells and human peripheral blood cells: anti-inflammatory and cytotoxic effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Survival; Down-Regulation; Gliotoxin; Humans; Jurkat Cells; Leukocytes, Mononuclear; NF-kappa B; RNA, Messenger; Sesquiterpenes; Sesquiterpenes, Guaiane; Transcription, Genetic | 2003 |
Pseudoguaianolide sesquiterpene lactones with high activities against the human malaria parasite Plasmodium falciparum.
Topics: Animals; Antimalarials; Arnica; Flowers; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Phytotherapy; Plasmodium falciparum; Sesquiterpenes; Sesquiterpenes, Guaiane | 2004 |
Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1.
Topics: Active Transport, Cell Nucleus; Animals; Astrocytes; Bradykinin; Cells, Cultured; Chromones; Flavonoids; Gene Expression Regulation; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Morpholines; NF-kappaB-Inducing Kinase; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction | 2004 |
Involvement of p42/p44 MAPK, JNK, and NF-kappaB in IL-1beta-induced ICAM-1 expression in human pulmonary epithelial cells.
Topics: Cell Line, Tumor; Drug Synergism; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Intercellular Adhesion Molecule-1; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Pulmonary Alveoli; RNA, Messenger; Sesquiterpenes; Sesquiterpenes, Guaiane | 2005 |
Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Androstadienes; Antineoplastic Agents, Phytogenic; Benzophenanthridines; Cell Differentiation; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HL-60 Cells; Humans; Indoles; Lactones; Maleimides; Models, Biological; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Wortmannin | 2005 |
The trypanocidal effect of sesquiterpene lactones helenalin and mexicanin on cultured epimastigotes.
Topics: Animals; Asteraceae; Lactones; Microscopy, Electron; Nitroimidazoles; Plant Extracts; Plant Leaves; Sesquiterpenes; Sesquiterpenes, Guaiane; Trypanocidal Agents; Trypanosoma cruzi | 2005 |
BK-induced cytosolic phospholipase A2 expression via sequential PKC-delta, p42/p44 MAPK, and NF-kappaB activation in rat brain astrocytes.
Topics: Acetophenones; Animals; Astrocytes; Benzopyrans; Bradykinin; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Phospholipases A; Phospholipases A2; Phosphorylation; Protein Kinase C-delta; Rats; Receptors, Bradykinin; RNA, Messenger; Sesquiterpenes; Sesquiterpenes, Guaiane | 2006 |
Activation of nuclear factor-kappaB contributes to induction of death receptors and apoptosis by the synthetic retinoid CD437 in DU145 human prostate cancer cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 8; Caspases; Cell Line, Tumor; Humans; I-kappa B Proteins; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Prostatic Neoplasms; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Retinoids; Sesquiterpenes; Sesquiterpenes, Guaiane; Up-Regulation | 2005 |
Potent inhibition of human telomerase by helenalin.
Topics: Antineoplastic Agents, Phytogenic; DNA-Binding Proteins; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; HL-60 Cells; Humans; In Vitro Techniques; Jurkat Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Sesquiterpenes, Guaiane; Telomerase; Toxins, Biological | 2005 |
Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation.
Topics: Acetylation; Butadienes; Cell Adhesion; Cells, Cultured; Chromatin Immunoprecipitation; Curcumin; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Histones; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; Myocytes, Smooth Muscle; Neutrophils; NF-kappa B; Nitriles; p300-CBP Transcription Factors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Time Factors; Trachea; Transcription, Genetic; Transfection; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2006 |
NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.
Topics: Anti-Infective Agents; Antimicrobial Cationic Peptides; beta-Defensins; Binding Sites; Biotinylation; Cell Line; Crohn Disease; DNA, Complementary; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Frameshift Mutation; Genes, Reporter; Humans; Intracellular Signaling Peptides and Proteins; Keratinocytes; Ligands; Luciferases; Mutagenesis, Site-Directed; Mutation; NF-kappa B; Nod2 Signaling Adaptor Protein; Peptides; Peptidoglycan; Plasmids; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Small Interfering; Sesquiterpenes; Sesquiterpenes, Guaiane; Transcription Factor AP-1; Transfection | 2006 |
Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols.
Topics: Animals; Apoptosis; B-Lymphocytes; Breast; Catechin; Cell Nucleus; Cells, Cultured; Curcumin; Diet; Fibroblasts; Flavonoids; Heme Oxygenase-1; Humans; Mice; Mice, Knockout; NF-E2-Related Factor 2; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphatidylinositol 3-Kinases; Polyphenols; Sesquiterpenes; Sesquiterpenes, Guaiane | 2006 |
Nuclear factor-kappaB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cysteine Proteinase Inhibitors; Drug Interactions; Gene Expression Regulation; Immunohistochemistry; Interleukin-6; Leupeptins; Male; NF-kappa B; Rats; Rats, Inbred Lew; Reperfusion Injury; Retina; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sesquiterpenes; Sesquiterpenes, Guaiane; Time Factors | 2006 |
Delayed radioprotection by nuclear transcription factor kappaB -mediated induction of manganese superoxide dismutase in human microvascular endothelial cells after exposure to the free radical scavenger WR1065.
Topics: Blotting, Western; Cells, Cultured; Endothelium, Vascular; Enzyme Induction; Free Radical Scavengers; Humans; Mercaptoethylamines; NF-kappa B; Radiation-Protective Agents; Sesquiterpenes; Sesquiterpenes, Guaiane; Superoxide Dismutase; X-Rays | 2006 |
TNF-alpha-induced optic nerve degeneration and nuclear factor-kappaB p65.
Topics: Animals; Axons; Blotting, Western; Immunohistochemistry; In Situ Nick-End Labeling; Injections; Male; Myelin Basic Protein; Nerve Degeneration; Oligodeoxyribonucleotides, Antisense; Optic Nerve; Rats; Rats, Inbred Lew; Retina; Sesquiterpenes; Sesquiterpenes, Guaiane; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Vitreous Body | 2006 |
BLIMP-1 is a target of cellular stress and downstream of the unfolded protein response.
Topics: Animals; B-Lymphocytes; Cycloheximide; Dithiothreitol; DNA-Binding Proteins; eIF-2 Kinase; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; HeLa Cells; HL-60 Cells; Humans; Macrophages; Mice; Mice, Inbred C57BL; Nuclear Proteins; Positive Regulatory Domain I-Binding Factor 1; Protein Folding; Protein Synthesis Inhibitors; Regulatory Factor X Transcription Factors; Repressor Proteins; RNA, Messenger; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Thapsigargin; Transcription Factors | 2006 |
Novel effect of helenalin on Akt signaling and Skp2 expression in 3T3-L1 preadipocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3T3-L1 Cells; Animals; Cell Cycle; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p27; Dexamethasone; Gene Expression Regulation; Insulin; MAP Kinase Signaling System; Mice; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; S-Phase Kinase-Associated Proteins; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction | 2006 |
Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Blotting, Western; Bucladesine; Cell Survival; Cells, Cultured; Chorionic Gonadotropin; Corticosterone; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Hydroxycholesterols; Leydig Cells; Male; Phosphoproteins; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Sesquiterpenes, Guaiane; Testosterone; Tetrazolium Salts; Time Factors | 2006 |
Skin penetration behaviour of sesquiterpene lactones from different Arnica preparations using a validated GC-MSD method.
Topics: Algorithms; Animals; Arnica; Drug Stability; Ear, External; Gas Chromatography-Mass Spectrometry; Gels; In Vitro Techniques; Lactones; Ointments; Plant Extracts; Reproducibility of Results; Sesquiterpenes; Sesquiterpenes, Guaiane; Skin Absorption; Swine | 2007 |
Helenalin reduces Staphylococcus aureus infection in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cell Line; Cells, Cultured; Colony Count, Microbial; Disease Models, Animal; Female; Injections, Intraperitoneal; Mammary Glands, Animal; Mastitis, Bovine; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Sesquiterpenes; Sesquiterpenes, Guaiane; Staphylococcal Infections; Staphylococcus aureus; Tumor Necrosis Factor-alpha | 2007 |
The autocrine TNFalpha signalling loop in keratinocytes requires atypical PKC species and NF-kappaB activation but is independent of cholesterol-enriched membrane microdomains.
Topics: Antibodies, Monoclonal; Autocrine Communication; beta-Cyclodextrins; Carbazoles; Cell Line; Cholesterol; Dose-Response Relationship, Drug; Humans; Indoles; Infliximab; Keratinocytes; Membrane Microdomains; NF-kappa B; Protein Kinase C; Receptors, Tumor Necrosis Factor, Type I; RNA, Messenger; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Tumor Necrosis Factor-alpha | 2007 |
Effect of vehicles on topical application of aloe vera and arnica montana components.
Topics: Administration, Cutaneous; Aloe; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Arnica; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Diffusion; Emodin; Emulsions; Excipients; Gels; Humans; Permeability; Pharmaceutical Vehicles; Plant Extracts; Sesquiterpenes; Sesquiterpenes, Guaiane; Skin Absorption; Swine | 2007 |
Natural sesquiterpene lactones are active against Leishmania mexicana.
Topics: Animals; Antiprotozoal Agents; Artemisia; Asteraceae; Chlorocebus aethiops; DNA Fragmentation; DNA, Protozoan; In Situ Nick-End Labeling; Lactones; Leishmania mexicana; Microscopy, Electron, Transmission; Sesquiterpenes; Sesquiterpenes, Guaiane; Vero Cells | 2008 |
Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyte proliferation.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; Cell Differentiation; Cell Nucleus; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; G1 Phase; Gene Expression Regulation; Mice; Sesquiterpenes; Sesquiterpenes, Guaiane; Stem Cells; Ubiquitination | 2008 |
Sesquiterpene lactones in Arnica montana: helenalin and dihydrohelenalin chemotypes in Spain.
Topics: Arnica; Chromatography, Liquid; Flowers; Isomerism; Lactones; Phenols; Plant Extracts; Sesquiterpenes; Sesquiterpenes, Guaiane; Spain | 2009 |
Cigarette smoke extract induces cytosolic phospholipase A2 expression via NADPH oxidase, MAPKs, AP-1, and NF-kappaB in human tracheal smooth muscle cells.
Topics: Acetophenones; Acetylcysteine; Butadienes; Cells, Cultured; Curcumin; Cytoplasm; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Kinase Kinases; Myocytes, Smooth Muscle; NADPH Oxidases; NF-kappa B; Nitriles; Onium Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A2; RNA, Small Interfering; Sesquiterpenes; Sesquiterpenes, Guaiane; Smoking; Trachea; Transcription Factor AP-1; Transcriptional Activation | 2009 |
Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Becaplermin; Bronchi; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chronic Disease; Cyclic AMP Response Element-Binding Protein; Cytokines; Dexamethasone; Dimethyl Fumarate; Enzyme Inhibitors; Fumarates; Glucocorticoids; Humans; I-kappa B Proteins; Immunosuppressive Agents; Interleukin-6; Isoquinolines; Myocytes, Smooth Muscle; NF-KappaB Inhibitor alpha; Platelet-Derived Growth Factor; Pneumonia; Proto-Oncogene Proteins c-sis; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Small Interfering; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfonamides; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2009 |
Effects of hyaluronan oligosaccharide on the expression of MMP-1 in periodontal ligament cells.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Hyaluronic Acid; Imidazoles; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Oligosaccharides; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Pyridines; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2 | 2009 |
Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms.
Topics: Antigens, CD; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; CD4-Positive T-Lymphocytes; Cell Cycle Proteins; Cell Proliferation; Humans; Interferon-gamma; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Membrane Potential, Mitochondrial; NF-kappa B; NFATC Transcription Factors; Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sesquiterpenes; Sesquiterpenes, Guaiane; Tumor Suppressor Protein p53 | 2009 |
Surface plasmon resonance analysis of nuclear factor-kappaB protein interactions with the sesquiterpene lactone helenalin.
Topics: Binding Sites; Biosensing Techniques; Glutathione; Hydrogen-Ion Concentration; I-kappa B Kinase; Immobilized Proteins; Protein Binding; Recombinant Proteins; Sesquiterpenes; Sesquiterpenes, Guaiane; Surface Plasmon Resonance; Transcription Factor RelA | 2010 |
Quantitative analysis of sesquiterpene lactones in extract of Arnica montana L. by 1H NMR spectroscopy.
Topics: Arnica; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Drug Design; Flowers; Lactones; Magnetic Resonance Spectroscopy; Models, Chemical; Plant Extracts; Sesquiterpenes; Sesquiterpenes, Guaiane | 2011 |
Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κb and mitogen-activated protein kinase in RAW264.7 ce
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Dinoprostone; DNA; Forsythia; Fruit; I-kappa B Kinase; Lignans; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Plant Extracts; Sesquiterpenes; Sesquiterpenes, Guaiane | 2010 |
Activation and induction of cytosolic phospholipase A2 by TNF-α mediated through Nox2, MAPKs, NF-κB, and p300 in human tracheal smooth muscle cells.
Topics: Acetophenones; Acetylation; Acetylcysteine; Cell Line; Curcumin; Dinoprostone; E1A-Associated p300 Protein; Enzyme Inhibitors; Free Radical Scavengers; Histones; Humans; Membrane Glycoproteins; Metabolic Networks and Pathways; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; NADPH Oxidase 2; NADPH Oxidases; NF-kappa B; Onium Compounds; Phospholipases A2; Phosphorylation; Sesquiterpenes; Sesquiterpenes, Guaiane; Trachea; Tumor Necrosis Factor-alpha | 2011 |
Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Caspase 8; Culture Media, Conditioned; Extracellular Signal-Regulated MAP Kinases; Humans; Matrix Metalloproteinase 2; Microglia; Monocytes; Mycobacterium tuberculosis; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Tuberculosis, Central Nervous System; Tumor Necrosis Factor-alpha | 2011 |
Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-κB and promoting reactive oxygen species generation.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cells, Cultured; Cytoprotection; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Humans; Membrane Potential, Mitochondrial; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Sesquiterpenes; Sesquiterpenes, Guaiane | 2011 |
Supercritical fluid extraction assisted isolation of sesquiterpene lactones with antiproliferative effects from Centipeda minima.
Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Cell Cycle Checkpoints; Cell Line, Tumor; Chromatography, Supercritical Fluid; Cisplatin; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Lactones; Magnetic Resonance Spectroscopy; Sesquiterpenes; Sesquiterpenes, Germacrane; Sesquiterpenes, Guaiane; Stereoisomerism; X-Ray Diffraction | 2012 |
NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Arnica; Autophagy; Autophagy-Related Protein 12; Caspases; Cell Line, Tumor; Dose-Response Relationship, Drug; G1 Phase; Humans; Microtubule-Associated Proteins; Neoplasms; Phytotherapy; Plant Extracts; Receptors, NK Cell Lectin-Like; RNA, Small Interfering; Sesquiterpenes; Sesquiterpenes, Guaiane; Small Ubiquitin-Related Modifier Proteins | 2012 |
Th17-associated cytokines promote human airway smooth muscle cell proliferation.
Topics: Apoptosis; Asthma; Benzamides; Bronchi; Cell Proliferation; Cell Survival; Cells, Cultured; Cytokines; Humans; Immunohistochemistry; Interleukin-17; Interleukin-22; Interleukins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; NF-kappa B; Phosphorylation; Receptors, Interleukin; Receptors, Interleukin-17; RNA Interference; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Th17 Cells | 2012 |
Helenalin-induced apoptosis is dependent on production of reactive oxygen species and independent of induction of endoplasmic reticulum stress in renal cell carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; DNA Fragmentation; Endoplasmic Reticulum Stress; Humans; Kidney Neoplasms; Reactive Oxygen Species; Sesquiterpenes; Sesquiterpenes, Guaiane | 2013 |
NF-κB-dependent and -independent pathways in the protective effects of activated protein C in hippocampal and cortical neurons at excitotoxicity.
Topics: Animals; Apoptosis Inducing Factor; Caspase 3; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Hippocampus; Neurons; NF-kappa B; Protein C; Rats; Rats, Wistar; Sesquiterpenes; Sesquiterpenes, Guaiane | 2013 |
The archaic roles of the amphioxus NF-κB/IκB complex in innate immune responses.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Nucleus; Chordata, Nonvertebrate; HEK293 Cells; HeLa Cells; Humans; I-kappa B Proteins; Immunity, Innate; Molecular Sequence Data; NF-kappa B; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Transcriptional Activation | 2013 |
Delta-opioid receptors attenuate TNF-α-induced MMP-2 secretion from human ONH astrocytes.
Topics: Analysis of Variance; Astrocytes; Benzamides; Blotting, Western; Cells, Cultured; Enzyme Inhibitors; Humans; Immunohistochemistry; Matrix Metalloproteinase 2; NF-kappa B; Optic Disk; p38 Mitogen-Activated Protein Kinases; Piperazines; Receptors, Opioid, delta; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Tumor Necrosis Factor-alpha | 2013 |
TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by helenalin.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Cell Line; Chemokine CXCL10; Cyclooxygenase 2; Humans; Interferon Regulatory Factor-3; Lipopeptides; Mice; Myeloid Differentiation Factor 88; NF-kappa B; Nitric Oxide Synthase Type II; Protein Serine-Threonine Kinases; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Toll-Like Receptors | 2013 |
Inhibitory effects of β-cyclodextrin-helenalin complexes on H-TERT gene expression in the T47D breast cancer cell line - results of real time quantitative PCR.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; beta-Cyclodextrins; Breast Neoplasms; Cell Proliferation; Female; Humans; Nanoparticles; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequestering Agents; Sesquiterpenes; Sesquiterpenes, Guaiane; Spectroscopy, Fourier Transform Infrared; Telomerase; Tumor Cells, Cultured | 2013 |
Analysis of gene profiles involved in the enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by sesquiterpene lactones identifies asparagine synthetase as a novel target for differentiation-inducing therapy.
Topics: Asparagine; Aspartate-Ammonia Ligase; Cell Differentiation; Culture Media; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Oligonucleotide Array Sequence Analysis; Receptors, Retinoic Acid; Sesquiterpenes; Sesquiterpenes, Guaiane; Tretinoin | 2014 |
Helenalin attenuates alcohol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and suppressing HSC activation.
Topics: Animals; Asteraceae; Cytokines; Disease Models, Animal; Ethanol; Gene Expression Regulation; Lipid Peroxidation; Liver Cirrhosis, Experimental; Male; NF-kappa B; Oxidative Stress; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Sesquiterpenes; Sesquiterpenes, Guaiane; Specific Pathogen-Free Organisms | 2014 |
The inhibitory effect of helenalin on telomerase activity is attributed to the alkylation of the CYS445 residue: evidence from QM/MM simulations.
Topics: Alkylation; Animals; Catalytic Domain; Computer Simulation; Cysteine; Enzyme Inhibitors; Insect Proteins; Kinetics; Models, Molecular; Protein Binding; Protein Structure, Secondary; Quantum Theory; Sesquiterpenes; Sesquiterpenes, Guaiane; Telomerase; Thermodynamics; Tribolium | 2014 |
Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?
Topics: Animals; Apoptosis; Artemisia; Chlorocebus aethiops; Lactones; Molecular Structure; Nifurtimox; Nitroimidazoles; Sesquiterpenes; Sesquiterpenes, Guaiane; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2014 |
RANKL promotes migration and invasion of hepatocellular carcinoma cells via NF-κB-mediated epithelial-mesenchymal transition.
Topics: Antigens, CD; Antineoplastic Agents, Phytogenic; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Collagenases; Diffusion Chambers, Culture; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Neoplasm Invasiveness; NF-kappa B; Nuclear Proteins; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Twist-Related Protein 1; Vimentin | 2014 |
A comparison of the inhibitory effect of nano-encapsulated helenalin and free helenalin on telomerase gene expression in the breast cancer cell line, by real-time PCR.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Carriers; Gene Expression Regulation, Neoplastic; Humans; Lactic Acid; Nanocapsules; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Real-Time Polymerase Chain Reaction; Safety; Sesquiterpenes; Sesquiterpenes, Guaiane; Telomerase | 2016 |
An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Cell Proliferation; Humans; Leukemia, Myeloid, Acute; Mice; Molecular Targeted Therapy; Protein Isoforms; Sesquiterpenes; Sesquiterpenes, Guaiane | 2016 |
Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis.
Topics: Animals; Biomarkers; Cartilage, Articular; Cytokines; Dinoprostone; Disease Models, Animal; Gene Expression; Knee Joint; Male; Matrix Metalloproteinase 13; NF-kappa B; Osteoarthritis; Purinergic P2X Receptor Antagonists; Rats; Receptors, Purinergic P2X7; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction | 2016 |
Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300.
Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; CCAAT-Enhancer-Binding Protein-beta; Mice; NF-kappa B; p300-CBP Transcription Factors; Protein Isoforms; Sesquiterpenes; Sesquiterpenes, Guaiane | 2016 |
Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types.
Topics: Anti-Inflammatory Agents; Apoptosis; Carbohydrate Metabolism; Cell Line, Tumor; Cell Survival; Cytokines; Humans; Leukocytes, Mononuclear; Metabolome; Oxidative Stress; Proteome; Reactive Oxygen Species; Sesquiterpenes; Sesquiterpenes, Guaiane | 2017 |
Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.
Topics: A549 Cells; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Design; HeLa Cells; Humans; Mice; Molecular Docking Simulation; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; Transcription Factor RelA | 2017 |
Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones.
Topics: Animals; Antiprotozoal Agents; Bridged-Ring Compounds; Cells, Cultured; Drug Evaluation, Preclinical; Furans; Inhibitory Concentration 50; Lactones; Leishmania infantum; Leishmaniasis, Visceral; Macrophages, Peritoneal; Mice, Inbred BALB C; Nitric Oxide; Sesquiterpenes; Sesquiterpenes, Germacrane; Sesquiterpenes, Guaiane; Sesterterpenes | 2017 |
Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.
Topics: A549 Cells; Cysteine; Humans; Kinetics; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfhydryl Compounds; Transcription Factor RelA | 2018 |
A surface antigen of
Topics: Antigens, Surface; Cell Proliferation; Dendritic Cells; Humans; Imidazoles; Monocytes; NF-kappa B; Orientia tsutsugamushi; p38 Mitogen-Activated Protein Kinases; Pyridines; Scrub Typhus; Sesquiterpenes; Sesquiterpenes, Guaiane; Signal Transduction; T-Lymphocytes; Toll-Like Receptor 4 | 2018 |
Preparation of Sesquiterpene Lactone Derivatives: Cytotoxic Activity and Selectivity of Action.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Humans; Lactones; Sesquiterpenes; Sesquiterpenes, Guaiane | 2019 |