Page last updated: 2024-08-22

helenalin and cysteine

helenalin has been researched along with cysteine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's3 (33.33)18.2507
2000's1 (11.11)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
ElGebaly, SA; HADGRAFT, RI; Hall, IH; Lee, KH; Mar, EC; Ruffner, CG; Starnes, CO; Waddell, TG; Weidner, I1
Hall, IH; Lee, KH; Mar, EC; Starnes, CO; Waddell, TG1
Leven, W; Lösche, W; Schröder, H; Schrör, K; Strobach, H; Till, U; Willuhn, G1
Gaspar, AR; Neitz, AW; Vermeulen, NM; Verschoor, JA1
Schmidt, TJ1
Lyss, G; Merfort, I; Pahl, HL; Schmidt, TJ1
Heilmann, J; Schmidt, TJ; Wasescha, MR1
Cheung, HY; Xu, L; Zhang, Z1
Baur, JW; Brown, DA; Brown, TJ; Edwards, JT; Harki, DA; Kempema, AM; Meece, FA; Skopec, HM; Widen, JC1

Other Studies

9 other study(ies) available for helenalin and cysteine

ArticleYear
Sesquiterpene antitumor agents: inhibitors of cellular metabolism.
    Science (New York, N.Y.), 1977, Apr-29, Volume: 196, Issue:4289

    Topics: Alkylation; Animals; Antimetabolites, Antineoplastic; Carcinoma, Ehrlich Tumor; Cholesterol; Cyclic AMP; Cysteine; DNA, Neoplasm; Glycolysis; Lactones; Male; Nucleic Acid Synthesis Inhibitors; Oxygen Consumption; Rats; RNA, Neoplasm; Sesquiterpenes; Sesquiterpenes, Guaiane; Structure-Activity Relationship; Sulfhydryl Compounds

1977
Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Ascitic Fluid; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Chromatin; Cyclopentanes; Cysteine; DNA, Neoplasm; Glutathione; Histidine; Lactones; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mice; Mice, Inbred DBA; Neoplasm Proteins; Rats; Sesquiterpenes; Sesquiterpenes, Guaiane; Spectrophotometry, Ultraviolet; Time Factors

1977
Helenalin and 11 alpha,13-dihydrohelenalin, two constituents from Arnica montana L., inhibit human platelet function via thiol-dependent pathways.
    Thrombosis research, 1990, Mar-15, Volume: 57, Issue:6

    Topics: Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cysteine; Humans; Phospholipases A; Phospholipases A2; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfhydryl Reagents; Thromboxane B2

1990
The influence of the sesquiterpene lactones from Geigeria on mast cell degranulation.
    Biochemical pharmacology, 1987, Aug-01, Volume: 36, Issue:15

    Topics: Alkylation; Animals; Cysteine; Ethylmaleimide; Histamine Release; Lactones; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Plant Extracts; Rats; Rats, Inbred Strains; Sesquiterpenes; Sesquiterpenes, Guaiane; Thapsigargin

1987
Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomolecules.
    Bioorganic & medicinal chemistry, 1997, Volume: 5, Issue:4

    Topics: Antineoplastic Agents, Phytogenic; Binding, Competitive; Cysteine; Glutathione; Magnetic Resonance Spectroscopy; Models, Molecular; Sesquiterpenes; Sesquiterpenes, Guaiane; Stereoisomerism; Structure-Activity Relationship; Toxins, Biological

1997
Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions.
    Bioorganic & medicinal chemistry, 1999, Volume: 7, Issue:12

    Topics: Binding Sites; Cysteine; Glutathione; Hydrogen-Ion Concentration; Kinetics; Lactones; Magnetic Resonance Spectroscopy; Models, Chemical; NF-kappa B; Sesquiterpenes; Sesquiterpenes, Guaiane; Spectrophotometry, Ultraviolet

1999
The influence of glutathione and cysteine levels on the cytotoxicity of helenanolide type sesquiterpene lactones against KB cells.
    Bioorganic & medicinal chemistry, 2001, Volume: 9, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Survival; Cysteine; Drug Interactions; Glutathione; Humans; KB Cells; Lactones; Sesquiterpenes; Sesquiterpenes, Guaiane; Tumor Cells, Cultured

2001
The inhibitory effect of helenalin on telomerase activity is attributed to the alkylation of the CYS445 residue: evidence from QM/MM simulations.
    Journal of molecular graphics & modelling, 2014, Volume: 51

    Topics: Alkylation; Animals; Catalytic Domain; Computer Simulation; Cysteine; Enzyme Inhibitors; Insect Proteins; Kinetics; Models, Molecular; Protein Binding; Protein Structure, Secondary; Quantum Theory; Sesquiterpenes; Sesquiterpenes, Guaiane; Telomerase; Thermodynamics; Tribolium

2014
Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.
    ChemMedChem, 2018, 02-20, Volume: 13, Issue:4

    Topics: A549 Cells; Cysteine; Humans; Kinetics; Sesquiterpenes; Sesquiterpenes, Guaiane; Sulfhydryl Compounds; Transcription Factor RelA

2018