harmol has been researched along with harmine in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (47.95) | 18.7374 |
| 1990's | 16 (21.92) | 18.2507 |
| 2000's | 8 (10.96) | 29.6817 |
| 2010's | 10 (13.70) | 24.3611 |
| 2020's | 4 (5.48) | 2.80 |
| Authors | Studies |
|---|---|
| Guengerich, FP; Stöckigt, J; Strobl, GR; von Kruedener, S; Wolff, T | 1 |
| Bastow, KF; Hu, CQ; Ishida, J; Lee, KH; Wang, HK | 1 |
| Cosentino, ML; Hu, CQ; Ishida, J; Lee, KH; Oyama, M; Wang, HK | 1 |
| Deng, Y; Duan, J; Kesuma, D; Qi, RZ; Sim, MM; Song, Y; Teng, SF; Wang, J; Wang, JH | 1 |
| Auerbach, K; Cuny, GD; Glicksman, MA; Higgins, JM; Lin, X; Liu, JF; Patnaik, D; Ray, SS; Stein, RL; Ulyanova, NP; Xian, J | 1 |
| Gooyit, M; Janda, KD; Javor, S; Lustigman, S; Tricoche, N | 1 |
| Jarhad, DB; Jeong, LS; Kim, HR; Mashelkar, KK; Noh, M | 1 |
| Dai, JK; Dan, WJ; Wan, JB | 1 |
| Mulder, GJ; Scholtens, E | 2 |
| Koster, H; Mulder, GJ; Scholtens, E | 1 |
| Andersson, B; Jones, DP; Orrenius, S | 1 |
| Keulemans, K; Mulder, GJ | 1 |
| Mulder, GJ; Pilon, AH | 1 |
| Bleeker, B; Mulder, GJ | 1 |
| Moncrieff, J | 1 |
| Elliott, SL; Morgan, DJ; Smallwood, RA | 1 |
| Curtis, CG; Powell, GM; Roy, AB; Shali, NA | 1 |
| Ghabrial, H; Mihaly, GW; Morgan, DJ; Murdoch, RT; Smallwood, RA | 1 |
| Dickens, BF; Mak, IT; Tse, SY | 1 |
| Meerman, JH; Meijer, EA; Mulder, GJ; Noort, D; Van Boom, JH; Van der Marel, GA; Visser, TJ | 1 |
| Sit, KH; Tan, TM; Wong, KP | 2 |
| Balón, M; Carmona, C; Hidalgo, J; Muñoz, MA | 1 |
| Bourke, CA; Carrigan, MJ; Dixon, RJ | 1 |
| Mulder, GJ | 1 |
| Gregus, Z; Howell, S; Klaassen, CD; White, C | 1 |
| Angus, PW; Mihaly, GW; Morgan, DJ; Smallwood, RA | 2 |
| Cook, JA; Guzman, F; Hagen, TJ; Shannon, HE | 1 |
| Araya, H; Awazu, S; Hayashi, M; Horie, T; Mizuma, T | 2 |
| Anderson, JD; Angus, PW; Ching, MS; Mihaly, GW; Smallwood, RA | 1 |
| de Vries, MH; Groothuis, GM; Meijer, DK; Mulder, GJ; Nguyen, H | 1 |
| Dawson, JR; Mulder, GJ; Pang, KS; Stillwell, RN; Weitering, JG | 1 |
| Dawson, JR; Mulder, GJ; Pang, KS; Scholtens, E; Weitering, JG | 1 |
| Carpentier, RG | 1 |
| Brendel, K; Sundheimer, DW | 1 |
| Baranczyk-Kuzma, A; Glazenburg, EJ; Jekel-Halsema, IM; Krijgsheld, KR; Mulder, GJ | 1 |
| Wong, KP; Yeo, T | 1 |
| Halsema, IC; Koster, H; Mulder, GJ; Pang, KS; Scholtens, E; Stillwell, RN | 1 |
| Burke, MD; Tweedie, DJ | 1 |
| Meerman, JH; Mulder, GJ; Sterenborg, HM | 1 |
| Douglas, KT; Hider, RC; Sharma, RK; Walmsley, JF | 1 |
| Halsema, I; Knippers, M; Koster, H; Mulder, GJ; Scholtens, E | 1 |
| Koster, HJ; Krijgsheld, KR; Mulder, GJ; Scholtens, E | 1 |
| Berggren, M; Cha, YN; Dock, L; Jernström, B; Moldéus, P | 1 |
| Halsema, I; Koster, H; Meerman, JH; Mulder, GJ; Pang, KS; Scholtens, E | 1 |
| Koster, HJ; Mulder, GJ; Temmink, TJ | 1 |
| Halsema, I; Koster, H; Mulder, GJ; Pang, KS; Scholtens, E | 1 |
| Rane, A; Steiner, E; von Bahr, C | 1 |
| Halsema, IC; Koster, H; Mulder, GJ; Pang, KS; Scholtens, E | 1 |
| Begum, S; Faizi, S; Farnaz, S; Gilani, AH; Saeed, SA; Siddiqui, BS; Siddiqui, S; Simjee, RU; Zia, A | 1 |
| Seah, VM; Wong, KP | 1 |
| Elliott, SL; Ghabrial, H; Guttmann, A; Morgan, DJ; Smallwood, RA; Watson, RG | 1 |
| Boles, JW; Klaassen, CD | 1 |
| Altun, ML; Kartal, M; Kurucu, S | 1 |
| Brouwer, KL; Kalvass, JC; Nezasa, K; Patel, NJ; Raub, TJ; Tian, X; Zamek-Gliszczynski, MJ | 1 |
| Belinsky, MG; Bridges, AS; Brouwer, KL; Kruh, GD; Lee, K; Nezasa, K; Tian, X; Zamek-Gliszczynski, MJ | 1 |
| Cruz, AP; Landeira-Fernandez, J; Motta, V; Santos, RG; Strassman, RJ | 1 |
| Abe, A; Yamada, H | 1 |
| Bolton, EC; Diamond, MI; Feau, C; Guy, RK; Hann, B; Huang, Y; Jones, JO; Yamamoto, KR | 1 |
| Abe, A; Miyazawa, K; Moriya, S; Yamada, H | 1 |
| Denison, MS; El Gendy, MA; El-Kadi, AO; Soshilov, AA | 1 |
| Abe, A; Kokuba, H | 1 |
| Cheng, X; Deng, Z; Gong, C; Gu, S; Liu, W; Teng, L; Wang, C; Wang, Z; Zhang, L | 1 |
| Benavente, F; Gagliardi, LG; Tascón, M; Vizioli, NM | 1 |
| Castilla, V; Damonte, EB; Panozzo Zénere, JD; Piccini, LE; Ponce, MA; Quintana, VM | 1 |
| Cabrerizo, FM; Cerioni, L; González, MM; Olmedo, GM; Rapisarda, VA; Volentini, SI | 1 |
| Ashfeld, BL; Bacher, EP; Banerjee, M; Eckert, KE; Gulotty, EM; Hill, HM; Huizar, FJ; Liu, H; Rodriguez, KX; Tucker, ZD; Wiest, O; Zartman, J | 1 |
| Dai, J; Duan, L; Han, Y; Hou, Q; Hu, R; Li, N; Liu, H; Ren, S; Wang, C; Wang, J; Wang, T; Wang, W; Wang, X; Xiao, S; Yang, Z | 1 |
| Ballesteros-Gonzalez, Á; Costa-Machado, LF; Del Pino, I; Duerr, JS; Eisenberg, T; Fabregat-Safont, D; Fernandez-Marcos, PJ; Fornari, T; Galindo, MI; Garcia-Dominguez, E; Gomez, J; Gomez-Cabrera, MC; Herradon, G; Hofer, SJ; Houtkooper, RH; Lopez-Aceituno, JL; Loza, MI; Madeo, F; Magnes, C; McIntyre, RL; Megias, D; Perez, M; Plaza, A; Pozo, OJ; Sierra-Ramirez, A; Tapia-Gonzalez, A; Villanueva-Bermejo, D; Viña, J | 1 |
2 review(s) available for harmol and harmine
| Article | Year |
|---|---|
Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics.
Topics: Animals; Biological Products; Disease; Dyrk Kinases; Enzyme Activation; Humans; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases | 2018 |
Natural and synthetic β-carboline as a privileged antifungal scaffolds.
Topics: Animals; Antifungal Agents; Biological Products; Carbolines; Drug Discovery; Female; Humans; Male; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycoses; Protein Binding; Signal Transduction; Structure-Activity Relationship | 2022 |
1 trial(s) available for harmol and harmine
| Article | Year |
|---|---|
Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members.
Topics: Adult; Anxiety; Banisteriopsis; Beverages; Brazil; Depressive Disorder; Double-Blind Method; Female; Fruit; Harmaline; Harmine; Humans; Male; Middle Aged; Molecular Structure; N,N-Dimethyltryptamine; Panic; Plant Extracts; Plant Leaves; Psychometrics; Religion; Surveys and Questionnaires; Treatment Outcome | 2007 |
70 other study(ies) available for harmol and harmine
| Article | Year |
|---|---|
Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies.
Topics: Alkaloids; Computer Simulation; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Ethanolamines; Humans; Indoles; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Molecular Conformation; Molecular Structure; Quinidine; Quinolines; Secologanin Tryptamine Alkaloids; Yohimbine | 1993 |
Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
Topics: Antineoplastic Agents; Carbolines; Drug Screening Assays, Antitumor; Harmine; Humans; Tumor Cells, Cultured | 1999 |
Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Furans; Harmine; Humans; Lignans; Lymphocytes; Molecular Structure; Plants, Medicinal; Structure-Activity Relationship | 2001 |
Beta-carbolines as specific inhibitors of cyclin-dependent kinases.
Topics: Carbolines; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Protein Serine-Threonine Kinases | 2002 |
Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.
Topics: Animals; Carbolines; Dyrk Kinases; Humans; Intracellular Signaling Peptides and Proteins; Mice; Microsomes, Liver; Models, Molecular; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship | 2012 |
Exploiting the Polypharmacology of ß-Carbolines to Disrupt O. volvulus Molting.
Topics: | 2015 |
Phenol sulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and vitro. 2,6-Dichloro-4-nitrophenol as selective inhibitor of sulphation.
Topics: Animals; Bile; Glucuronosyltransferase; Harmaline; Harmine; In Vitro Techniques; Liver; Male; Nitrophenols; Pentachlorophenol; Rats; Sulfurtransferases; Time Factors | 1977 |
Inhibition of sulfation of phenols in vivo by 2,6-dichloro-4-nitrophenol: selectivity of its action in relation to other conjugations in the rat in vivo.
Topics: Animals; Bile; Dose-Response Relationship, Drug; Ethacrynic Acid; Glucuronates; Harmine; Male; Nitrophenols; Phenolphthaleins; Phenols; Procainamide; Rats; Sulfates | 1979 |
Effect of calcium ions on ethanol oxidation and drug glucuronidation in isolated hepatocytes.
Topics: Alkaloids; Animals; Calcium; Ethanol; Harmine; In Vitro Techniques; Liver; Male; Oxidation-Reduction; Rats; Stimulation, Chemical | 1979 |
The availability of inorganic sulphate in blood for sulphate conjugation of drugs in rat liver in vivo. (35S)Sulphate incorporation into harmol sulphate.
Topics: Alkaloids; Animals; Bile; Harmine; Kinetics; Liver; Male; Rats; Sulfates | 1978 |
Metabolism of inorganic sulphate in the isolated perfused rat liver. Effect of sulphate concentration on the rate of sulphation by phenol sulphotransferase.
Topics: Animals; Bile; Glucuronates; Harmine; In Vitro Techniques; Kinetics; Liver; Male; Phenols; Phosphoadenosine Phosphosulfate; Rats; Sulfates; Sulfurtransferases | 1978 |
UDP glucuronyltransferase and phenolsulfotransferase from rat liver in vivo and in vitro. III. The effect of phenolphthalein and its sulfate and glucuronide conjugate on conjugation and biliary excretion of harmol.
Topics: Adenosine Monophosphate; Alkaloids; Animals; Bile; Depression, Chemical; Glucuronates; Glucuronosyltransferase; Harmine; Hexosyltransferases; In Vitro Techniques; Indoles; Liver; Male; Organophosphorus Compounds; Phenolphthaleins; Phenols; Pyridines; Rats; Sulfates; Sulfuric Acids; Sulfurtransferases | 1975 |
UDP glucuronyltransferase and phenolsulfotransferase from rat liver in vivo and in vitro--IV. Species differences in harmol conjugation and elimination in bile and urine in vivo.
Topics: Adenosine Monophosphate; Alkaloids; Animals; Bile; Cats; Glucuronates; Glucuronosyltransferase; Guinea Pigs; Harmine; Hexosyltransferases; In Vitro Techniques; Indoles; Liver; Male; Mice; Phenols; Rabbits; Rats; Species Specificity; Sulfates; Sulfurtransferases; Time Factors | 1975 |
Extractionless determination of diclofenac sodium in serum using reversed-phase high-performance liquid chromatography with fluorimetric detection.
Topics: Chromatography, High Pressure Liquid; Diclofenac; Drug Stability; Harmine; Humans; Spectrometry, Fluorescence | 1992 |
Fasting increases the sensitivity of hepatic harmol glucuronidation to hypoxia.
Topics: Animals; Body Weight; Fasting; Glucuronates; Harmine; Humans; Hypoxia; Liver; Male; Oxygen; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 1992 |
Sulphation of the flavonoids quercetin and catechin by rat liver.
Topics: Animals; Bile; Catechin; Chromatography, Thin Layer; Glucuronidase; Harmine; Hydrolysis; In Vitro Techniques; Liver; Nitrophenols; Perfusion; Quercetin; Rats; Sulfates; Sulfur Radioisotopes | 1991 |
Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver.
Topics: Albuterol; Animals; Bile; Erythrocytes; Glucuronates; Harmine; Liver; Malaria; Male; Metabolic Clearance Rate; Oxidation-Reduction; Pharmaceutical Preparations; Plasmodium berghei; Propranolol; Rats; Rats, Inbred Strains; Taurocholic Acid | 1991 |
Antioxidative properties of harmane and beta-carboline alkaloids.
Topics: Animals; Antioxidants; Carbolines; Dose-Response Relationship, Drug; Free Radicals; Harmaline; Harmine; Lipid Peroxidation; Male; Microsomes, Liver; Models, Chemical; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiobarbiturates; Tryptamines | 1991 |
Selective inhibition of glucuronidation by 2,2,2-triphenylethyl-UDP in isolated rat hepatocytes: conjugation of harmol, 3,3',5-triiodothyronine, and N-hydroxy-2-acetylaminofluorene.
Topics: Animals; Cells, Cultured; Fluorenes; Glucuronates; Glucuronosyltransferase; Harmine; Liver; Male; Rats; Rats, Inbred Strains; Sulfates; Triiodothyronine; Uridine Diphosphate | 1991 |
Expression of a high-affinity form of UDP-glucuronosyltransferase in human foetal liver cells in culture on exposure to mercuric chloride.
Topics: Cells, Cultured; Cycloheximide; Glucuronosyltransferase; Harmine; Humans; Kinetics; Liver; Mercuric Chloride; Naphthols | 1991 |
UDP-glucuronyltransferase activity toward harmol in human liver and human fetal liver cells in culture.
Topics: Alkaloids; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Fetus; Fluorometry; Glucuronates; Glucuronosyltransferase; Harmine; Humans; Kinetics; Liver; Methods; Microsomes, Liver | 1990 |
Fluorescence of harmol, harmalol and 2-hydroxycarbazole in concentrated hydroxide solutions.
Topics: Carbazoles; Harmaline; Harmine; Hydrogen-Ion Concentration; Hydroxides; Potassium; Potassium Compounds; Solutions; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1990 |
Upper motor neurone effects in sheep of some beta-carboline alkaloids identified in zygophyllaceous plants.
Topics: Alkaloids; Animals; Carbolines; Female; Harmaline; Harmine; Locomotion; Motor Neurons; Plants, Toxic; Sheep | 1990 |
Kinetics of sulfation in the rat in vivo and in the perfused rat liver.
Topics: Alkaloids; Animals; Dogs; Glucuronosyltransferase; Harmine; Hymecromone; Kinetics; Liver; Liver Circulation; Nitrophenols; Pentachlorophenol; Perfusion; Phosphoadenosine Phosphosulfate; Rats; Sulfates; Sulfobromophthalein; Sulfurtransferases | 1986 |
Effect of glutathione depletion on sulfate activation and sulfate ester formation in rats.
Topics: Animals; Dichloroethylenes; Glutathione; Harmine; Ketones; Liver; Male; Maleates; Phosphoadenosine Phosphosulfate; Rats; Rats, Inbred Strains; Sulfates | 1988 |
Synergistic effects of hypoxia and fasting on harmol elimination in the isolated perfused rat liver.
Topics: Alkaloids; Animals; Fasting; Glucose; Harmine; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Oxygen Consumption; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Uridine Diphosphate Glucuronic Acid | 1988 |
Beta-carbolines as antagonists of the discriminative stimulus effects of diazepam in rats.
Topics: Animals; Carbolines; Diazepam; Discrimination Learning; Harmine; Male; Picrotoxin; Rats; Rats, Inbred F344 | 1988 |
Hypoxia impairs conjugation and elimination of harmol in the isolated perfused rat liver.
Topics: Alkaloids; Anaerobiosis; Animals; Cells, Cultured; Harmine; Hypoxia; Kinetics; Liver; Male; Oxygen Consumption; Rats; Rats, Inbred Strains | 1987 |
Heterogeneous distribution of the conjugation activity of acetaminophen and p-nitrophenol in isolated rat liver cells.
Topics: Acetaminophen; Animals; Cell Fractionation; Glucuronates; Harmine; In Vitro Techniques; Liver; Male; Nitrophenols; Rats; Rats, Inbred Strains; Sulfates | 1986 |
High-performance liquid chromatographic analysis of harmol and its conjugated metabolites after enzyme hydrolysis in biological fluids.
Topics: Alkaloids; Body Fluids; Chromatography, High Pressure Liquid; Half-Life; Harmine; Humans; Hydrolysis; Liver; Perfusion | 1986 |
Secretion of the organic anion harmol sulfate from liver into blood. Evidence for a carrier-mediated mechanism.
Topics: Alkaloids; Animals; Bile; Biological Transport; Harmine; Kinetics; Liver; Male; Protein Binding; Rats; Rats, Inbred Strains; Serum Albumin; Sulfobromophthalein; Sulfuric Acids | 1985 |
Alteration of transit time and direction of flow to probe the heterogeneous distribution of conjugating activities for harmol in the perfused rat liver preparation.
Topics: Alkaloids; Animals; Glucuronates; Harmine; In Vitro Techniques; Kinetics; Liver; Liver Circulation; Male; Models, Biological; Perfusion; Rats; Rats, Inbred Strains; Sulfates | 1985 |
Heterogeneous distribution of conjugation activities of harmol in isolated rat liver cells.
Topics: 5'-Nucleotidase; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Alkaloids; Animals; Cell Fractionation; Cell Separation; Cytochrome P-450 Enzyme System; Glucuronates; Harmine; In Vitro Techniques; Kinetics; Liver; Male; Nucleotidases; Perfusion; Portal Vein; Rats; Rats, Inbred Strains; Sulfates | 1984 |
Extrahepatic sulfation and glucuronidation in the rat in vivo. Determination of the hepatic extraction ratio of harmol and the extrahepatic contribution to harmol conjugation.
Topics: Alkaloids; Animals; Glucuronates; Harmine; Infusions, Parenteral; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains; Sulfuric Acids | 1984 |
Effects of betacarbolines on the automaticity of the guinea pig sinus node.
Topics: Alkaloids; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Guinea Pigs; Harmaline; Harmine; Sinoatrial Node; Structure-Activity Relationship | 1984 |
Factors influencing sulfation in isolated rat hepatocytes.
Topics: Animals; Cysteine; Ethanol; Glucuronates; Harmine; Lithium; Liver; Male; Rats; Rats, Inbred Strains; Sulfates | 1984 |
D-cysteine as a selective precursor for inorganic sulfate in the rat in vivo. Effect of D-cysteine on the sulfation of harmol.
Topics: Alkaloids; Animals; Cysteine; Dietary Proteins; Harmine; Kidney; Male; Rats; Rats, Inbred Strains; Stereoisomerism; Sulfates | 1984 |
Importance of extrahepatic sulphate conjugation.
Topics: Animals; Female; Guinea Pigs; Haplorhini; Harmine; Intestine, Small; Isoproterenol; Kidney; Liver; Lung; Male; Mice; Rabbits; Rats; Species Specificity; Sulfates; Sulfurtransferases | 1982 |
Normal and retrograde perfusion to probe the zonal distribution of sulfation and glucuronidation activities of harmol in the perfused rat liver preparation.
Topics: Alkaloids; Animals; Biotransformation; Computers; Glucuronates; Harmine; Liver; Liver Circulation; Male; Models, Biological; Perfusion; Rats; Rats, Inbred Strains; Sulfates | 1983 |
Differential effects of phenobarbitone and 3-methylcholanthrene induction on the hepatic microsomal metabolism of the beta-carbolines harmine and harmol.
Topics: Alkaloids; Animals; Carbolines; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Induction; Harmine; Indoles; Kinetics; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital | 1983 |
Use of pentachlorophenol as long-term inhibitor of sulfation of phenols and hydroxamic acids in the rat in vivo.
Topics: Animals; Chlorophenols; Harmine; Hydroxamic Acids; Kinetics; Male; Pentachlorophenol; Phenols; Rats; Rats, Inbred Strains; Species Specificity | 1983 |
Ionization processes of some harmala alkaloids.
Topics: Alkaloids; Harmaline; Harmine; Hydrogen-Ion Concentration; Ions; Kinetics; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1983 |
Dose-dependent shifts in the sulfation and glucuronidation of phenolic compounds in the rat in vivo and in isolated hepatocytes. The role of saturation of phenolsulfotransferase.
Topics: Animals; Arylsulfotransferase; Glucuronates; Harmine; Kinetics; Liver; Male; Phenols; Rats; Rats, Inbred Strains; Sulfates; Sulfurtransferases | 1981 |
Cholestatic effect of harmol glucuronide in the rat. Prevention of harmol-induced cholestasis by increased formation of harmol sulfate.
Topics: Alkaloids; Animals; Cholestasis; Diet; Glucuronates; Harmine; Liver; Male; Rats; Rats, Inbred Strains; Sulfates; Time Factors | 1982 |
Elevation of conjugation capacity in isolated hepatocytes from BHA-treated mice.
Topics: Acetaminophen; Animals; Anisoles; Biotransformation; Butylated Hydroxyanisole; Female; Glutathione; Harmine; In Vitro Techniques; Inactivation, Metabolic; Liver; Mice | 1982 |
Selective inhibition of sulfate conjugation in the rat: pharmacokinetics and characterization of the inhibitory effect of 2,6-dichloro-4-nitrophenol.
Topics: Animals; Harmine; In Vitro Techniques; Kinetics; Liver; Male; Nitrophenols; Perfusion; Protein Binding; Rats; Sulfates | 1982 |
The effect of fasting on sulfation and glucuronidation in the rat in vivo.
Topics: Animals; Bile; Biotransformation; Fasting; Glucuronates; Harmine; Liver; Rats; Sulfates | 1982 |
Kinetics of sulfation and glucuronidation of harmol in the perfused rat liver preparation. Disappearance of aberrances in glucuronidation kinetics by inhibition of sulfation.
Topics: Alkaloids; Animals; Cholestasis; Glucuronates; Harmine; Kinetics; Liver; Male; Metabolic Clearance Rate; Nitrophenols; Rats; Rats, Inbred Strains; Sulfates | 1982 |
Sulphate and glucuronic acid conjugation of harmol in human fetal and adult liver tissue.
Topics: Adult; Aged; Alkaloids; Female; Fetus; Glucuronates; Harmine; Humans; Liver; Male; Middle Aged; Pregnancy; Sulfates; Time Factors | 1982 |
Aberrant Pharmacokinetics of harmol in the perfused rat liver preparation: sulfate and glucuronide conjugations.
Topics: Alkaloids; Animals; Blood Proteins; Glucuronates; Harmine; Kinetics; Liver; Male; Models, Biological; Protein Binding; Rats; Rats, Inbred Strains; Sulfates | 1981 |
Inhibition of platelet aggregation and arachidonic acid metabolism by B-carboline alkaloids.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Blood Platelets; Harmaline; Harmine; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 1993 |
2,6-Dichloro-4-nitrophenol (DCNP), an alternate-substrate inhibitor of phenolsulfotransferase.
Topics: Animals; Arylsulfotransferase; Cytosol; Dopamine; Harmine; Kinetics; Liver; Nitrophenols; Rats; Sulfates | 1994 |
Effect of erythrocyte binding on elimination of harmol by the isolated perfused rat liver.
Topics: Animals; Cells, Cultured; Erythrocytes; Harmine; Liver; Male; Oxygen; Perfusion; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine | 1996 |
Effects of molybdate on the sulfation of harmol and alpha-naphthol.
Topics: Administration, Oral; Animals; Biotransformation; Chromatography, High Pressure Liquid; Harmine; Infusions, Intravenous; Injections, Intraperitoneal; Male; Molybdenum; Naphthols; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence; Sulfotransferases; Sulfuric Acid Esters | 1998 |
HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.
Topics: Chromatography, High Pressure Liquid; Harmaline; Harmine; Peganum; Reproducibility of Results; Seeds; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2003 |
[On 2 pharmacological properties, not yet known, of harmol].
Topics: Alkaloids; Blood Pressure; Blood Pressure Determination; Epinephrine; Harmine; Humans | 1963 |
The important role of Bcrp (Abcg2) in the biliary excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in mice.
Topics: Acetaminophen; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Bile; Glucuronides; Harmine; Hymecromone; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Sulfates | 2006 |
Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Glucuronides; Harmine; Hymecromone; In Vitro Techniques; Liver; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Sulfates | 2006 |
Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas ligand interaction in human lung carcinoma H596 cells.
Topics: Adenocarcinoma; Apoptosis; Carcinoma, Adenosquamous; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Enzyme Activation; Fas Ligand Protein; fas Receptor; Harmaline; Harmine; Humans; Lung Neoplasms; Neoplasm Proteins | 2009 |
Non-competitive androgen receptor inhibition in vitro and in vivo.
Topics: Androgen Receptor Antagonists; Animals; Cell Line; Cell Proliferation; Harmine; Humans; Male; Mice; Molecular Structure; Pyrvinium Compounds; Receptors, Androgen | 2009 |
The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Harmine; Humans; Microscopy, Electron; Nitriles; Phytotherapy; Plant Extracts; RNA, Small Interfering | 2011 |
Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol.
Topics: Animals; Carcinogens; Cytochrome P-450 CYP1A1; Dioxins; Gene Expression; Guinea Pigs; Harmine; Hep G2 Cells; Humans; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Protein Biosynthesis; Transcription, Genetic | 2012 |
Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation of survivin.
Topics: Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation, Neoplastic; Glioma; Harmine; Humans; Inhibitor of Apoptosis Proteins; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Survivin; TOR Serine-Threonine Kinases | 2013 |
Simultaneous determination of harmine, harmaline and their metabolites harmol and harmalol in beagle dog plasma by UPLC-ESI-MS/MS and its application to a pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Female; Harmaline; Harmine; Male; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
A rapid and simple method for the determination of psychoactive alkaloids by CE-UV: application to Peganum Harmala seed infusions.
Topics: Alkaloids; Carbolines; Electrophoresis, Capillary; Harmaline; Harmine; Limit of Detection; Monoamine Oxidase Inhibitors; Peganum; Plant Extracts; Psychotropic Drugs; Seeds; Time Factors | 2017 |
Antiviral activity of natural and synthetic β-carbolines against dengue virus.
Topics: Animals; Antiviral Agents; Carbolines; Chlorocebus aethiops; Dengue Virus; Drug Discovery; Genome, Viral; Harmine; Humans; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Viral; Vero Cells; Virus Replication | 2016 |
Antifungal activity of β-carbolines on Penicillium digitatum and Botrytis cinerea.
Topics: Botrytis; Carbolines; Citrus; Fruit; Fungicides, Industrial; Germination; Harmine; Microbial Sensitivity Tests; Mycelium; Penicillium; Spores, Fungal | 2017 |
Rational Design and Identification of Harmine-Inspired, N-Heterocyclic DYRK1A Inhibitors Employing a Functional Genomic In Vivo Drosophila Model System.
Topics: Animals; Dose-Response Relationship, Drug; Drosophila; Drosophila Proteins; Drug Design; Dyrk Kinases; Harmine; Heterocyclic Compounds; Humans; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship | 2022 |
9-Butyl-Harmol Exerts Antiviral Activity against Newcastle Disease Virus through Targeting GSK-3β and HSP90β.
Topics: Animals; Antiviral Agents; beta Catenin; Glycogen Synthase Kinase 3 beta; Harmine; HSP90 Heat-Shock Proteins; Humans; Newcastle Disease; Newcastle disease virus | 2023 |
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models.
Topics: Adipose Tissue, Brown; Aging; AMP-Activated Protein Kinase Kinases; Animals; Antidepressive Agents; Caenorhabditis elegans; Drosophila melanogaster; Fatty Liver; Female; Frailty; Glucose Intolerance; Harmine; Insulin Resistance; Liver; Longevity; Male; Mice; Mitochondria; Mitophagy; Models, Animal; Monoamine Oxidase; Muscle Fibers, Skeletal; Muscle, Skeletal; Physical Conditioning, Animal; Prediabetic State; Receptors, GABA-A | 2023 |