harmine and quinoline

harmine has been researched along with quinoline* in 2 studies

Other Studies

2 other study(ies) available for harmine and quinoline

Article	Year
Ultrasound mediated catalyst free synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-ones leading to novel quinoline derivatives: their evaluation as potential anti-cancer agents. Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2 A facile and catalyst free synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-ones has been accomplished via the reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with various aromatic amines in the presence of ultrasound. Some of these compounds were converted to the corresponding 2-(3-(hydroxymethyl)quinolin-2-yl)phenols and further structure elaboration of a representative quinoline derivative is presented. Molecular structure of two representative compounds was confirmed by single crystal X-ray diffraction study. Many of these compounds were evaluated for their anti-proliferative properties in vitro against four cancer cell lines and several compounds were found to be active. Further in vitro studies indicated that inhibition of sirtuins could be the possible mechanism of action of these molecules. Topics: Antineoplastic Agents; Benzopyrans; Binding Sites; Catalysis; Catalytic Domain; Cell Line, Tumor; Computer Simulation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Quinolines; Sirtuin 1; Sonication	2012
A spectroscopic study of the hydrogen bonding and pi-pi stacking interactions of harmane with quinoline. Biospectroscopy, 1998, Volume: 4, Issue:3 A spectroscopic (UV-vis, Fourier transform IR, steady state, and time-resolved fluorescence) study of the interactions of the ground and excited singlet states of harmane (1-methyl-9H-pyrido/3,4-b/indole) with quinoline has been carried out in cyclohexane, toluene, and buffered pH=8.7 aqueous solutions. To analyze how the number of rings in the substrate influences these interactions, pyridine and phenanthridine have also been included in this study. In cyclohexane and toluene 1:1 stoichiometric hydrogen-bonded complexes are formed in both the ground and the excited singlet states. As the number of rings of the benzopyridines and the solvent polarity increase hydrogen-bonding interactions weaken and pi-pi van der Waals interactions become apparent. Topics: Buffers; Cyclohexanes; Harmine; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Structure; Quinolines; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Toluene	1998

Article

Year

Ultrasound mediated catalyst free synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-ones leading to novel quinoline derivatives: their evaluation as potential anti-cancer agents.

Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2

A facile and catalyst free synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-ones has been accomplished via the reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with various aromatic amines in the presence of ultrasound. Some of these compounds were converted to the corresponding 2-(3-(hydroxymethyl)quinolin-2-yl)phenols and further structure elaboration of a representative quinoline derivative is presented. Molecular structure of two representative compounds was confirmed by single crystal X-ray diffraction study. Many of these compounds were evaluated for their anti-proliferative properties in vitro against four cancer cell lines and several compounds were found to be active. Further in vitro studies indicated that inhibition of sirtuins could be the possible mechanism of action of these molecules.

Topics: Antineoplastic Agents; Benzopyrans; Binding Sites; Catalysis; Catalytic Domain; Cell Line, Tumor; Computer Simulation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Quinolines; Sirtuin 1; Sonication

2012

A spectroscopic study of the hydrogen bonding and pi-pi stacking interactions of harmane with quinoline.

Biospectroscopy, 1998, Volume: 4, Issue:3

A spectroscopic (UV-vis, Fourier transform IR, steady state, and time-resolved fluorescence) study of the interactions of the ground and excited singlet states of harmane (1-methyl-9H-pyrido/3,4-b/indole) with quinoline has been carried out in cyclohexane, toluene, and buffered pH=8.7 aqueous solutions. To analyze how the number of rings in the substrate influences these interactions, pyridine and phenanthridine have also been included in this study. In cyclohexane and toluene 1:1 stoichiometric hydrogen-bonded complexes are formed in both the ground and the excited singlet states. As the number of rings of the benzopyridines and the solvent polarity increase hydrogen-bonding interactions weaken and pi-pi van der Waals interactions become apparent.

Topics: Buffers; Cyclohexanes; Harmine; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Structure; Quinolines; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Toluene

1998