harman and 4-amino-3-phenylbutyric-acid

In conditions in which rats had a free choice between dark and light chambers, microinjections of glutamic acid, serotonin, and campiron into the globus pallidus showed that these agents have antiaversive properties in a threatening situation test but not in an illuminated area test. Dopamine, apomorphine, GABA, chlordiazepoxide, phenibut, and indoter injected locally into this formation of the basal ganglia had no effect on the mechanisms of voluntary movement but counteracted anxiety states in both behavioral models. These results provide evidence that the monoaminergic and aminoacidergic systems of the dorsal pallidum have different functional roles in the operative regulation of behavior for aversive stimuli of different modalities. Prior intraperitoneal administration of functional antagonists of these synaptotropic substances and subsequent microinjection of transmitter monoamines and amino acids and their agonists into the globus pallidus demonstrated the selective involvement of the neurotransmitter systems of the dorsal pallidum in the antiaversive effects of anxiosedative and anxioselective substances.

Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Biogenic Amines; Chlordiazepoxide; Fear; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Harmine; Male; Microinjections; Neurotransmitter Agents; Piperazines; Pyrimidines; Rats; Statistics, Nonparametric

Neurochemical analysis using anxiosedative and anxioselective agents injected into the hypothalamus revealed that antiaversive action of camprione is only realised under conditions of domineering fear motivation whereas that of chlordiazepoxide, phenibut, indoter may also be realised under conditions of negative stressful zoo-social impacts mediated by serotonin.

Topics: Adrenergic alpha-Antagonists; Amino Acids; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Biogenic Monoamines; Chlordiazepoxide; Dopamine D2 Receptor Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Harmine; Hypothalamus, Middle; Microinjections; Piperazines; Pyrimidines; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Serotonin Agents

Topics: Alkaloids; Allosteric Regulation; Animals; gamma-Aminobutyric Acid; Ganglia, Spinal; Harmine; In Vitro Techniques; Membrane Potentials; Neurons; Rats; Receptors, Serotonin; Serotonin