Compounds > harmaline

harmaline and harmine

harmaline has been researched along with harmine in 108 studies

Research

Studies (108)

TimeframeStudies, this research(%)All Research%
pre-199027 (25.00)18.7374
1990's13 (12.04)18.2507
2000's30 (27.78)29.6817
2010's30 (27.78)24.3611
2020's8 (7.41)2.80

Authors

AuthorsStudies
Deng, Y; Duan, J; Kesuma, D; Qi, RZ; Sim, MM; Song, Y; Teng, SF; Wang, J; Wang, JH1
Dukat, M; Glennon, RA; Grella, B; Herrick-Davis, K; Khorana, N; Purohit, A; Smith, C; Teitler, M1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Amado, Mdel R; Carrillo, AK; Galarreta, BC; Maruenda, H; Sanchez, L; Sifuentes, R1
Jiang, X; Liu, J; Peng, L; Peng, S; Zhang, X; Zhao, M; Zheng, M1
Li, C; Liu, J; Peng, S; Wang, Y; Wu, J; Zhang, X; Zhao, M; Zheng, M1
Changwichit, K; Ingkaninan, K; Khorana, N; Utsintong, M1
Bharate, SB; Jain, SK; Khan, IA; Khan, SI; Manda, S; Mohammed, S; Tekwani, BL; Vishwakarma, RA1
Ashok, P; Balaña-Fouce, R; Chander, S; García-Calvo, L; Murugesan, S; Tejería, A1
Bai, J; Bao, Y; Bin, W; Cao, F; Hua, HM; Jing, YK; Li, DH; Li, ZL; Lin, C; Pei, YH; Wang, KB; Wang, WJ; Yang, D1
Andrade, RB; Bougie, D; Boxer, MB; Brimacombe, KR; Brown, LE; Brown, MK; Burns, NZ; Cha, JK; Cheff, DM; Cheng, K; Clardy, J; Clement, JA; Coussens, NP; Crooks, PA; Cuny, GD; Dillon, C; Dorjsuren, D; Eastman, RT; Ganor, J; Garg, NK; Goess, BC; Grossman, RB; Guha, R; Hall, MD; Henderson, MJ; Huang, R; Hughes, CC; Iannotti, MJ; Inglese, J; Itkin, Z; Jadhav, A; Johnston, JN; Joullie, MM; Karavadhi, S; Kearney, SE; Kinghorn, AD; Kingston, DGI; Klumpp-Thomas, C; Krische, MJ; Kwon, O; Lee, TD; Lynch, C; Maimone, TJ; Majumdar, S; Maloney, KN; Mevers, EE; Michael, S; Mohamed, E; Moreno, J; Morrill, LA; Murphy, BT; Nagorny, P; Olson, DE; Overman, LE; Picazo, E; Porco, JA; Ren, T; Rivas, F; Rohde, JM; Ross, SA; Roth, JS; Sakamuru, S; Sarpong, R; Sharma, I; Shaw, JT; Shen, B; Shen, M; Shi, W; Shinn, P; Simeonov, A; Snyder, JK; Stephenson, CRJ; Sun, W; Susick, RB; Tan, DS; Tang, Y; Taylor, RE; Thomson, RJ; Titus, SA; Verano, AL; Vosburg, DA; Wan, KK; Wu, J; Wuest, WM; Xia, M; Xu, Z; Yasgar, A; Zahoránszky-Kőhalmi, G; Zakarian, A; Zhang, Y; Zhang, YQ; Zhao, J; Zhao, T; Zheng, W; Zuo, Z1
Dai, JK; Dan, WJ; Wan, JB1
Duggan, AW; Headley, PM; Lodge, D1
Bashford, CL; Charnock, JS; Ellory, JC1
Asano, Y; Marumo, F; Mishina, T; Tashima, Y1
Thiel, PG; van Rensburg, SJ; Wehner, FC1
Mulder, GJ; Scholtens, E1
Guha, SR; Mitra, C1
Aarons, DH; Orzechowski, RF; Rossi, GV1
Robinson, JW; Sepúlveda, FV1
Duportail, G; Lami, H1
Headley, PM; Lodge, D1
Issakainen, J; Liwszyc, GE; Rasanen, I; Vuori, E1
Ahmad, A; Begum, S; Faizi, S; Khan, KA; Siddiqui, BS; Siddiqui, S; Sultana, S1
Chemli, R; el Bahri, L1
Dickens, BF; Mak, IT; Tse, SY1
Balón, M; Carmona, C; Hidalgo, J; Muñoz, MA1
Al-Alaf, TA; Ayoub, MT; Rashan, LJ1
Bourke, CA; Carrigan, MJ; Dixon, RJ1
Moncrieff, J1
Longo, VG; Massotti, M1
Damm, H; Höfle, G; Rommelspacher, H; Susilo, R1
Cohen, ML; Wittenauer, LA1
Back, G; Iven, H; Zetler, G1
Airaksinen, MM; Saano, V1
Carpentier, RG2
Oderfeld-Nowak, B; Rommelspacher, H; Skup, M1
Douglas, KT; Hider, RC; Sharma, RK; Walmsley, JF1
Holmstedt, B1
Hider, RC; Smart, L; Suleiman, MS1
Smart, L1
Ono, M; Shimamine, M; Takahashi, K1
Lindemann, J; Rommelspacher, H; Strauss, S1
El-Saad El-Rifaie, M1
Begum, S; Faizi, S; Farnaz, S; Gilani, AH; Saeed, SA; Siddiqui, BS; Siddiqui, S; Simjee, RU; Zia, A1
Abdel-Fattah, AF; Gammaz, HA; Matsumoto, K; Watanabe, H1
Brito, GS; Callaway, JC; Grob, CS; Hearn, WL; Mash, DC; McKenna, DJ; Raymon, LP1
da Silva, KV; Erdtmann, B; Henriques, AT; Henriques, JA; Picada, JN1
Dukat, M; Gauthier, CB; Glennon, RA; Grella, B; Herrick-Davis, K; Teitler, M; Young, R1
Cassels, BK; Morello, A; Repetto, Y; Rivas, P1
Chen, CF; Liao, JF; Shi, CC2
Pineda, J; Ruiz-Durántez, E; Ugedo, L1
Xie, J; Xu, X; Zhu, L1
Bais, HP; Halligan, KM; Park, SW; Stermitz, FR; Vivanco, JM1
Altun, ML; Kartal, M; Kurucu, S1
Gonzalez, FJ; Idle, JR; Krausz, KW; Küpfer, A; Yu, AM1
Ferreira, D; Herath, W; Khan, IA; Mikell, JR1
GIAJA, J; MARKOVIC, L1
Beach, JW; Collins, MA; Gearhart, DA; Hwang, YI; Neafsey, EJ; Schwarz, J; Storch, A1
Bingmann, D; Bonnet, U; Büsselberg, D; Splettstoesser, F; Wiemann, M1
Callaway, JC2
Angenot, L; Azas, N; Balansard, G; Fiot, J; Jansen, O; Mahiou, V; Ollivier, E; Sanon, S1
Fukushima, S; Gohda, A; Inoue, H; Iwata, Y; Kishi, T; Kuwayama, K; Miyaguchi, H; Mohri, H; Tsujikawa, K1
Berrougui, H; Ettaib, A; Herrera, MD; Hmamouchi, M; Khalil, A; Marhuenda, E; Martín-Cordero, C1
Berrougui, H; Cloutier, M; Hmamouchi, M; Isabelle, M; Khalil, A1
Boeira, JM; Henriques, JA; Moura, DJ; Roesler, R; Rorig, C; Saffi, J; Vieira, DL1
Cruz, AP; Landeira-Fernandez, J; Motta, V; Santos, RG; Strassman, RJ1
Arjmand, A; Oody, A; Zaker, F1
Abdullaev, F; Espinosa-Aguirre, J; Jiménez, J; Riverón-Negrete, L; Rodríguez-Arnaiz, R1
Astulla, A; Ekasari, W; Hirasawa, Y; Matsuno, Y; Morita, H; Widyawaruyanti, A; Zaima, K; Zaini, NC1
Arshad, N; Hasnain, S; Hess, M; Zitterl-Eglseer, K1
Geng, Y; Liu, J; Shi, X; Wang, D; Wang, X1
Frecska, E1
Abedini, M; Aliasgharpour, M; Fathiazad, F; Movafeghi, A; Omidi, Y1
Abe, A; Yamada, H1
Ancín-Azpilicueta, C; Arán, VJ; González, D; Guillén, H; Herraiz, T1
Chaurasiya, ND; Joshi, VC; Khan, IA; Khan, SI; Miller, LS; Muhammad, I; Rahman, MM; Samoylenko, V; Tekwani, BL; Tripathi, LM; Wang, YH; Wigger, FT1
Bonsaii, M; Khalilzadeh, MA; Maali, P; Manouchehri, F; Nafisi, S1
Khalilzadeh, MA; Malekabady, ZM; Nafisi, S1
Ishii, H; Nakae, D; Nakagawa, Y; Ogata, A; Suzuki, T1
Adhami, HR; Farsam, H; Krenn, L1
Benedict, C; Crandall, I; Macmullin, G; Pillai, DR; Shahinas, D1
Bligh, SW; Li, YY; Wang, CH; Wang, ZT; Zhang, BF; Zhao, T; Zheng, SS1
Huang, X; Shao, H; Zhang, C; Zhang, Y1
El Gendy, MA; El-Kadi, AO1
Cheng, X; Deng, Z; Gong, C; Gu, S; Liu, W; Teng, L; Wang, C; Wang, Z; Zhang, L1
Benavente, F; Gagliardi, LG; Sanz-Nebot, VM; Tascon, M1
Benarous, K; Bombarda, I; Gaetan, H; Iriepa, I; Linani, A; Moraleda, I; Sebaa, M; Tahri, D; Yousfi, M1
Crippa, JA; Dos Santos, RG; Hallak, JE; Osório, FL1
Benavente, F; Gagliardi, LG; Tascón, M; Vizioli, NM1
Cheng, X; Jiang, B; Li, S; Liu, W; Teng, L; Wang, C; Wang, Z1
Badshah, S; Halimi, SA; Idrees, F; Idrees, J; Pervaiz, S; Salman, S; Shah, FH; Usman, M1
Guo, X; Li, B; Miao, X; Pan, H; Shang, X; Zhang, J; Zhang, Y1
Moghadamnia, AA; Tabari, MA; Youssefi, MR1
Alonso-Gil, S; de la Fuente Revenga, M; Feilding, A; Morales-García, JA; Perez-Castillo, A; Riba, J; Rodríguez-Franco, MI1
Chen, W; Cheng, X; Huang, L; Jiang, B; Li, S; Meng, L; Wang, C; Wang, H; Wang, Z; Zou, N1
Freitas, DP; Souza, RCZ; Sussulini, A; Tófoli, LFF; Zandonadi, FS1
Cabrerizo, FM; Denofrio, MP; Erra-Balsells, R; García Einschlag, FS; Rasse-Suriani, FAO; Schmidt De León, T; Villarruel, F1
Abouzeid, S; Hänsch, R; Hijazin, T; Lewerenz, L; Selmar, D1
Birk, L; Borges, GR; Eller, S; Grossi, P; Merib, JO; Oliveira, TF; Ossanes, DS; Scheid, C; Yonamine, M1
Banerjee, R; Chhabra, M; Das, R; Gaurav, I; Karak, S; Kumar, M; Singh, K; Thakur, A; Thakur, S1
Benarous, K; Bou-Salah, L; Linani, A; Yousfi, M1
Deng, S; Lv, X; Ma, XC; Sun, CP; Wei, F; Yi, J; Zhang, BJ; Zhao, WY1
Cao, N; Cheng, XM; Guan, HD; Wang, CH; Wang, YX1
Abdelazim, AH; Algarni, MA; Almalki, AH1

Reviews

3 review(s) available for harmaline and harmine

ArticleYear
Natural and synthetic β-carboline as a privileged antifungal scaffolds.
    European journal of medicinal chemistry, 2022, Feb-05, Volume: 229

    Topics: Animals; Antifungal Agents; Biological Products; Carbolines; Drug Discovery; Female; Humans; Male; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mycoses; Protein Binding; Signal Transduction; Structure-Activity Relationship

2022
Effect of tremorigenic agents on the cerebellum: a review of biochemical and electrophysiological data.
    International review of neurobiology, 1985, Volume: 26

    Topics: Alkaloids; Animals; Cats; Cerebellar Nuclei; Cerebellum; Cyclic GMP; Diazepam; Dopamine; Electroencephalography; gamma-Aminobutyric Acid; Harmaline; Harmine; Levodopa; Medulla Oblongata; Neural Pathways; Olivary Nucleus; Rabbits; Spinal Cord; Synaptic Transmission; Tremor

1985
Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies.
    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2016, Volume: 38, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Banisteriopsis; Depressive Disorder; Harmaline; Harmine; Humans; Mice; N,N-Dimethyltryptamine; Rats

2016

Trials

2 trial(s) available for harmaline and harmine

ArticleYear
Fast and slow metabolizers of Hoasca.
    Journal of psychoactive drugs, 2005, Volume: 37, Issue:2

    Topics: Area Under Curve; Banisteriopsis; Cytochrome P-450 CYP2D6; Harmaline; Harmine; Humans; N,N-Dimethyltryptamine; Phenotype; Plant Extracts; Plants; Time Factors

2005
Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members.
    Journal of ethnopharmacology, 2007, Jul-25, Volume: 112, Issue:3

    Topics: Adult; Anxiety; Banisteriopsis; Beverages; Brazil; Depressive Disorder; Double-Blind Method; Female; Fruit; Harmaline; Harmine; Humans; Male; Middle Aged; Molecular Structure; N,N-Dimethyltryptamine; Panic; Plant Extracts; Plant Leaves; Psychometrics; Religion; Surveys and Questionnaires; Treatment Outcome

2007

Other Studies

103 other study(ies) available for harmaline and harmine

ArticleYear
Beta-carbolines as specific inhibitors of cyclin-dependent kinases.
    Bioorganic & medicinal chemistry letters, 2002, Apr-08, Volume: 12, Issue:7

    Topics: Carbolines; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Protein Serine-Threonine Kinases

2002
Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.
    Journal of medicinal chemistry, 2003, Aug-28, Volume: 46, Issue:18

    Topics: Animals; Binding, Competitive; Carbolines; Cell Line; Humans; Mice; Radioligand Assay; Rats; Receptors, Serotonin; Structure-Activity Relationship

2003
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.
    Bioorganic & medicinal chemistry, 2008, Jul-15, Volume: 16, Issue:14

    Topics: Animals; Biological Products; Enzyme Inhibitors; Flavins; Harmaline; Indole Alkaloids; Leishmania; NADH, NADPH Oxidoreductases; Quinolines; Trypanocidal Agents; Trypanosoma cruzi

2008
A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency.
    Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8

    Topics: Amino Acids; Animals; Carbolines; Fibrinolytic Agents; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Stereoisomerism; Structure-Activity Relationship; Swine

2010
A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:11

    Topics: Animals; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Drug Design; Fibrinolytic Agents; Hydrazines; Male; Models, Molecular; Molecular Conformation; Platelet Aggregation; Platelet Aggregation Inhibitors; Quantitative Structure-Activity Relationship; Rats; Swine; Thrombosis

2011
Prospective acetylcholinesterase inhibitory activity of indole and its analogs.
    Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8

    Topics: Acetylcholinesterase; Binding Sites; Carbolines; Cholinesterase Inhibitors; Enzyme Activation; Humans; Indoles; Molecular Conformation; Quinolines

2012
Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines.
    Bioorganic & medicinal chemistry letters, 2014, Aug-01, Volume: 24, Issue:15

    Topics: Animals; Antiprotozoal Agents; Carbolines; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Leishmania donovani; Macrophages; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Swine; Trypanosoma brucei brucei; Vero Cells

2014
Synthesis and anti-leishmanial evaluation of 1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline derivatives against Leishmania infantum.
    European journal of medicinal chemistry, 2016, Nov-10, Volume: 123

    Topics: Animals; Antiprotozoal Agents; Carbolines; Chemistry Techniques, Synthetic; Female; Inhibitory Concentration 50; Leishmania infantum; Mice

2016
Structurally Diverse Alkaloids from the Seeds of Peganum harmala.
    Journal of natural products, 2017, 02-24, Volume: 80, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Carbolines; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; HL-60 Cells; Humans; Indole Alkaloids; Inhibitory Concentration 50; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peganum; Seeds

2017
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
    ACS central science, 2018, Dec-26, Volume: 4, Issue:12

    Topics:

2018
Drug-induced rhythmical activity in the inferior olivary complex of the rat.
    Brain research, 1976, Jan-23, Volume: 101, Issue:3

    Topics: Acetylcholine; Action Potentials; Animals; Atropine; Bicuculline; Dopamine; Fenclonine; Gallamine Triethiodide; gamma-Aminobutyric Acid; Glutamates; Glycine; Harmaline; Harmine; Male; Neurons; Norepinephrine; Olivary Nucleus; Pentobarbital; Rats; Serotonin; Strychnine; Tryptamines; Tubocurarine

1976
Effects of ATP and magnesium ions on the fluorescence of harmala alkaloids. Restrictions for the use of harmala alkaloids as fluorescent probes for (Na+ + K+)-ATPase.
    Biochimica et biophysica acta, 1976, Jun-17, Volume: 436, Issue:2

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alkaloids; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Enzyme Activation; Harmaline; Harmine; Kidney Cortex; Kidney Medulla; Kinetics; Magnesium; Mathematics; Ouabain; Protein Binding; Spectrometry, Fluorescence; Swine

1976
The inhibitory effect of reserpine on the active sodium transport across the frog bladder.
    Pflugers Archiv : European journal of physiology, 1976, Sep-03, Volume: 365, Issue:1

    Topics: Adenosine Triphosphatases; Animals; Biological Transport, Active; Chemical Phenomena; Chemistry; Depression, Chemical; Harmaline; Harmine; Rana catesbeiana; Reserpine; Sodium; Urinary Bladder

1976
Mutagenicity of alkaloids in the Salmonella/microsome system.
    Mutation research, 1979, Volume: 66, Issue:2

    Topics: Alkaloids; Animals; Cycasin; Drug Evaluation, Preclinical; Harmaline; Harmine; Microsomes, Liver; Mutagens; Pyrrolizidine Alkaloids; Rats; Salmonella typhimurium

1979
Phenol sulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and vitro. 2,6-Dichloro-4-nitrophenol as selective inhibitor of sulphation.
    The Biochemical journal, 1977, Sep-01, Volume: 165, Issue:3

    Topics: Animals; Bile; Glucuronosyltransferase; Harmaline; Harmine; In Vitro Techniques; Liver; Male; Nitrophenols; Pentachlorophenol; Rats; Sulfurtransferases; Time Factors

1977
Inhibition patterns of monoamine oxidase in sub-fractions of rat brain mitochondria in presence of some selective inhibitors.
    Biochemical pharmacology, 1979, Apr-01, Volume: 28, Issue:7

    Topics: Animals; Brain; Harmaline; Harmine; In Vitro Techniques; Male; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Selegiline; Serotonin; Substrate Specificity; Tyramine

1979
Cardiovascular actions of three harmala alkaloids: harmine, harmaline, and harmalol.
    Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:9

    Topics: Alkaloids; Animals; Atropine; Blood Pressure; Dogs; Female; Harmaline; Harmine; Heart Rate; Hemodynamics; Hindlimb; In Vitro Techniques; Male; Myocardial Contraction; Rats; Vagotomy; Vascular Resistance

1977
New characteristics of harmaline inhibition of intestinal transport systems.
    Naunyn-Schmiedeberg's archives of pharmacology, 1975, Volume: 291, Issue:2

    Topics: Alkaloids; Animals; Biological Transport; Chlorides; Dogs; Guinea Pigs; Hallucinogens; Harmaline; Harmine; Intestinal Absorption; Intestine, Small; Methylglucosides; N,N-Dimethyltryptamine; Phenylalanine; Potassium; Serotonin; Sodium; Water

1975
Studies of the interaction of the fluorophores harmine and harmaline with calf thymus DNA.
    Biochimica et biophysica acta, 1975, Aug-06, Volume: 402, Issue:1

    Topics: Alkaloids; Animals; Binding Sites; Cattle; DNA; Harmaline; Harmine; Nucleic Acid Denaturation; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Viscosity

1975
The effects of beta-carbolines on responses to acetylcholine, noradrenaline, 5-hydroxytryptamine and amino acids in the rat spinal cord.
    Brain research, 1976, Jan-23, Volume: 101, Issue:3

    Topics: Acetylcholine; Action Potentials; Animals; Carbolines; Drug Interactions; gamma-Aminobutyric Acid; Glycine; Harmaline; Harmine; Homocysteine; Indoles; Lysergic Acid Diethylamide; Male; Norepinephrine; Rats; Serotonin; Spinal Cord

1976
Daime--a ritual herbal potion.
    Journal of ethnopharmacology, 1992, Volume: 36, Issue:1

    Topics: Alkaloids; Gas Chromatography-Mass Spectrometry; Harmaline; Harmine; Indians, South American; N,N-Dimethyltryptamine; Plant Extracts; Plants, Medicinal; South America

1992
Study of the in vitro antimicrobial activity of harmine, harmaline and their derivatives.
    Journal of ethnopharmacology, 1992, Volume: 35, Issue:3

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Arthrodermataceae; Gram-Negative Bacteria; Gram-Positive Bacteria; Harmaline; Harmine; Microbial Sensitivity Tests

1992
Peganum harmala L: a poisonous plant of North Africa.
    Veterinary and human toxicology, 1991, Volume: 33, Issue:3

    Topics: Animals; Camelus; Harmaline; Harmine; Plant Poisoning; Plants, Toxic

1991
Antioxidative properties of harmane and beta-carboline alkaloids.
    Biochemical pharmacology, 1991, Jul-15, Volume: 42, Issue:3

    Topics: Animals; Antioxidants; Carbolines; Dose-Response Relationship, Drug; Free Radicals; Harmaline; Harmine; Lipid Peroxidation; Male; Microsomes, Liver; Models, Chemical; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiobarbiturates; Tryptamines

1991
Fluorescence of harmol, harmalol and 2-hydroxycarbazole in concentrated hydroxide solutions.
    Pharmaceutisch weekblad. Scientific edition, 1990, Aug-24, Volume: 12, Issue:4

    Topics: Carbazoles; Harmaline; Harmine; Hydrogen-Ion Concentration; Hydroxides; Potassium; Potassium Compounds; Solutions; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

1990
Synthesis and characterization of novel biologically active platinum(II) and palladium(II) complexes of some beta-carboline alkaloids.
    Journal of inorganic biochemistry, 1990, Volume: 38, Issue:1

    Topics: Alkaloids; Antineoplastic Agents; Antiviral Agents; Carbolines; Harmaline; Harmine; Magnetic Resonance Spectroscopy; Molecular Structure; Organometallic Compounds; Organoplatinum Compounds; Palladium; Spectrophotometry, Infrared; Spectrum Analysis, Raman; Tumor Cells, Cultured

1990
Upper motor neurone effects in sheep of some beta-carboline alkaloids identified in zygophyllaceous plants.
    Australian veterinary journal, 1990, Volume: 67, Issue:7

    Topics: Alkaloids; Animals; Carbolines; Female; Harmaline; Harmine; Locomotion; Motor Neurons; Plants, Toxic; Sheep

1990
Determination of pharmacological levels of harmane, harmine and harmaline in mammalian brain tissue, cerebrospinal fluid and plasma by high-performance liquid chromatography with fluorimetric detection.
    Journal of chromatography, 1989, Nov-24, Volume: 496, Issue:2

    Topics: Alkaloids; Animals; Brain; Chromatography, High Pressure Liquid; Harmaline; Harmine; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence

1989
Biotransformation of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-1-carboxylic acid to harmalan, tetrahydroharman and harman in rats.
    Neuroscience letters, 1987, Oct-29, Volume: 81, Issue:3

    Topics: Animals; Brain; Carbolines; Chromatography, High Pressure Liquid; Female; Harmaline; Harmine; Injections, Intraperitoneal; Rats; Rats, Inbred Strains; Viscera

1987
Relationship between serotonin and tryptamine receptors in the rat stomach fundus.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 233, Issue:1

    Topics: Animals; Gastric Fundus; Harmaline; Harmine; Male; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Stomach; Structure-Activity Relationship; Tryptamines

1985
PHARMACOKINETICS In the rat of the hallucinogenic alkaloids harmine and harmaline.
    Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 285, Issue:3

    Topics: Alkaloids; Animals; Blood Proteins; Chromatography, Thin Layer; Erythrocytes; Half-Life; Harmaline; Harmine; Heart Rate; Kinetics; Male; Organ Specificity; Protein Binding; Rats; Structure-Activity Relationship; Time Factors; Tremor

1974
Binding of beta-carbolines and caffeine on benzodiazepine receptors: correlations to convulsions and tremor.
    Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:4

    Topics: Animals; Brain; Caffeine; Carbolines; Flunitrazepam; Harmaline; Harmine; Indoles; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Seizures; Tremor

1982
Effects of betacarbolines on the automaticity of the guinea pig sinus node.
    Substance and alcohol actions/misuse, 1984, Volume: 5, Issue:3

    Topics: Alkaloids; Animals; Depression, Chemical; Dose-Response Relationship, Drug; Guinea Pigs; Harmaline; Harmine; Sinoatrial Node; Structure-Activity Relationship

1984
In vitro studies on the effect of beta-carbolines on the activities of acetylcholinesterase and choline acetyltransferase and on the muscarinic receptor binding of the rat brain.
    Journal of neurochemistry, 1983, Volume: 41, Issue:1

    Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Carbolines; Cattle; Choline O-Acetyltransferase; Erythrocytes; Harmaline; Harmine; Indoles; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Structure-Activity Relationship

1983
Ionization processes of some harmala alkaloids.
    Molecular pharmacology, 1983, Volume: 23, Issue:3

    Topics: Alkaloids; Harmaline; Harmine; Hydrogen-Ion Concentration; Ions; Kinetics; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

1983
Betacarbolines and tetrahydroisoquinolines: historical and ethnopharmacological background.
    Progress in clinical and biological research, 1982, Volume: 90

    Topics: Carbolines; Harmaline; Harmine; Indoles; Isoquinolines; Plants; Species Specificity; Structure-Activity Relationship; Tetrahydroisoquinolines

1982
The effect of harmaline and related harmala alkaloids on ouabain-stimulated contractions of the guinea-pig ileum.
    European journal of pharmacology, 1981, Apr-24, Volume: 71, Issue:1

    Topics: Alkaloids; Animals; Calcium; Dose-Response Relationship, Drug; Female; Guinea Pigs; Harmaline; Harmine; Ileum; Muscle Contraction; Muscle, Smooth; Ouabain

1981
Competitive inhibition of sodium-dependent high affinity choline uptake by harmala alkaloids.
    European journal of pharmacology, 1981, Nov-05, Volume: 75, Issue:4

    Topics: Alkaloids; Animals; Binding Sites; Choline; Corpus Striatum; Harmaline; Harmine; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Sodium; Synaptosomes

1981
[Identification of psychotropic drugs. Analysis of beta-carboline derivatives (author's transl)].
    Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, 1981, Volume: 99

    Topics: Alkaloids; Carbolines; Chromatography; Colorimetry; Hallucinogens; Harmaline; Harmine; Indoles; Microchemistry; Spectrophotometry, Ultraviolet

1981
Excretion of tetrahydroharmane and harmane into the urine of man and rat after a load with ethanol.
    FEBS letters, 1980, Jan-14, Volume: 109, Issue:2

    Topics: Adult; Alkaloids; Animals; Ethanol; Female; Harmaline; Harmine; Humans; Male; Mass Spectrometry; Rats; Spectrophotometry, Ultraviolet

1980
Peganum harmala: its use in certain dermatoses.
    International journal of dermatology, 1980, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Alkaloids; Child; Female; Harmaline; Harmine; Humans; Male; Middle Aged; Plant Extracts; Skin Diseases

1980
Effects of harmine on transmembrane potentials of guinea-pig atrial muscle.
    British journal of pharmacology, 1980, Volume: 69, Issue:4

    Topics: Action Potentials; Alkaloids; Animals; Guinea Pigs; Harmaline; Harmine; Heart; Heart Atria; Membrane Potentials; Norepinephrine

1980
Inhibition of platelet aggregation and arachidonic acid metabolism by B-carboline alkaloids.
    Biochemical Society transactions, 1993, Volume: 21, Issue:4

    Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Arachidonic Acid; Blood Platelets; Harmaline; Harmine; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2

1993
Hypothermic effect of harmala alkaloid in rats: involvement of serotonergic mechanism.
    Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:2

    Topics: Adrenergic beta-Antagonists; Alkaloids; Animals; Body Temperature; Dopamine Antagonists; Dose-Response Relationship, Drug; Harmaline; Harmine; Male; Monoamine Oxidase Inhibitors; Plant Extracts; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists

1995
Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca.
    Journal of analytical toxicology, 1996, Volume: 20, Issue:6

    Topics: Administration, Oral; Beverages; Brazil; Calibration; Chromatography, Gas; Chromatography, High Pressure Liquid; Diphenhydramine; Harmaline; Harmine; Humans; Male; N,N-Dimethyltryptamine; Nitrogen; Phosphorus; Reference Standards; Reproducibility of Results

1996
Genotoxic effects of structurally related beta-carboline alkaloids.
    Mutation research, 1997, Oct-06, Volume: 379, Issue:2

    Topics: Animals; Biotransformation; Carbolines; Escherichia coli; Female; Harmaline; Harmine; Liver; Male; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Rats; Rats, Sprague-Dawley; Salmonella typhimurium

1997
Investigation of hallucinogenic and related beta-carbolines.
    Drug and alcohol dependence, 1998, Apr-01, Volume: 50, Issue:2

    Topics: Animals; Carbolines; Conditioning, Operant; Confidence Intervals; Cues; Discrimination Learning; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Generalization, Stimulus; Hallucinogens; Harmaline; Harmine; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship; Time Factors

1998
Effects of some beta-carboline alkaloids on intact Trypanosoma cruzi epimastigotes.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1999, Volume: 122, Issue:1

    Topics: Animals; Carbolines; Harmaline; Harmine; Kinetics; Nifurtimox; Oxygen Consumption; Species Specificity; Trypanocidal Agents; Trypanosoma cruzi

1999
Comparative study on the vasorelaxant effects of three harmala alkaloids in vitro.
    Japanese journal of pharmacology, 2001, Volume: 85, Issue:3

    Topics: Animals; Aorta, Thoracic; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Endothelium, Vascular; Harmaline; Harmine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Vasodilator Agents

2001
Stimulatory effect of harmane and other beta-carbolines on locus coeruleus neurons in anaesthetized rats.
    Neuroscience letters, 2001, Aug-10, Volume: 308, Issue:3

    Topics: Anesthesia; Animals; Carbolines; Electrophysiology; Harmaline; Harmine; Imidazoline Receptors; Locus Coeruleus; Male; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Drug; Vagotomy

2001
Spasmolytic effects of three harmala alkaloids on guinea-pig isolated trachea.
    Pharmacology & toxicology, 2001, Volume: 89, Issue:5

    Topics: Adrenergic beta-Antagonists; Alkaloids; Animals; Binding, Competitive; Calcium Channels; Carbachol; Dose-Response Relationship, Drug; Guinea Pigs; Harmaline; Harmine; Histamine; Histamine Antagonists; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Potassium Chloride; Propranolol; Receptors, Adrenergic, beta-2; Receptors, Histamine H1; Receptors, Muscarinic; Trachea

2001
Affinitive separation and on-line identification of antitumor components from Peganum nigellastrum by coupling a chromatographic column of target analogue imprinted polymer with mass spectrometry.
    Analytical chemistry, 2002, May-15, Volume: 74, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Biosensing Techniques; Chromatography, High Pressure Liquid; Harmaline; Harmine; Mass Spectrometry; Peganum; Plant Extracts; Polymers; Seeds

2002
Exudation of fluorescent beta-carbolines from Oxalis tuberosa L roots.
    Phytochemistry, 2002, Volume: 61, Issue:5

    Topics: Arabidopsis; Carbolines; Fluorescence; Harmaline; Harmine; Magnetic Resonance Spectroscopy; Magnoliopsida; Phytolacca; Plant Roots

2002
HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.
    Journal of pharmaceutical and biomedical analysis, 2003, Feb-26, Volume: 31, Issue:2

    Topics: Chromatography, High Pressure Liquid; Harmaline; Harmine; Peganum; Reproducibility of Results; Seeds; Sensitivity and Specificity; Spectrophotometry, Ultraviolet

2003
Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; DNA, Complementary; Harmaline; Harmine; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Male; Mass Spectrometry; Methylation; Mice; Mice, Transgenic; Microsomes, Liver; Psychotropic Drugs

2003
Microbial metabolites of harman alkaloids.
    Chemical & pharmaceutical bulletin, 2003, Volume: 51, Issue:6

    Topics: Biotransformation; Cunninghamella; Harmaline; Harmine; Magnetic Resonance Spectroscopy; Molecular Structure; Rhodotorula

2003
[Harmine, thermoregulation and hypoxic lethargy].
    Journal de physiologie, 1951, Volume: 43, Issue:1

    Topics: Body Temperature Regulation; Harmaline; Harmine; Hypoxia; Lethargy; Sleep Stages

1951
Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake.
    Journal of neurochemistry, 2004, Volume: 89, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Carbolines; Cell Line; Cell Survival; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Harmaline; Harmine; Humans; Inhibitory Concentration 50; Kidney; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Methylation; Nerve Tissue Proteins; Parkinson Disease, Secondary; Piperazines

2004
Modulation of voltage-gated channel currents by harmaline and harmane.
    British journal of pharmacology, 2005, Volume: 144, Issue:1

    Topics: Animals; Calcium Channels; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Ganglia, Spinal; Harmaline; Harmine; Inhibitory Concentration 50; Ion Channel Gating; Neurons, Afferent; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Sodium Channels; Time Factors

2005
Various alkaloid profiles in decoctions of Banisteriopsis caapi.
    Journal of psychoactive drugs, 2005, Volume: 37, Issue:2

    Topics: Alkaloids; Banisteriopsis; Harmaline; Harmine; Hydrogen-Ion Concentration; N,N-Dimethyltryptamine; Pharmaceutical Preparations; Plant Extracts; Plants; Time Factors

2005
Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae).
    Journal of ethnopharmacology, 2006, Jun-30, Volume: 106, Issue:2

    Topics: Alkaloids; Animals; Antimalarials; Butanones; Carbolines; Cell Survival; Combretaceae; Drug Synergism; Harmaline; Harmine; HeLa Cells; Humans; Inhibitory Concentration 50; Monocytes; Naphthalenes; Oxindoles; Parasitic Sensitivity Tests; Plant Extracts; Plant Leaves; Plant Roots; Plasmodium falciparum; Rubiaceae

2006
Analysis of hallucinogenic constituents in Amanita mushrooms circulated in Japan.
    Forensic science international, 2006, Dec-20, Volume: 164, Issue:2-3

    Topics: Amanita; Atropine; Excitatory Amino Acid Agonists; Forensic Toxicology; GABA Agonists; Gas Chromatography-Mass Spectrometry; Harmaline; Harmine; Ibotenic Acid; Japan; Molecular Structure; Monoamine Oxidase Inhibitors; Muscarinic Antagonists; Muscimol; Scopolamine; Tryptamines

2006
Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seeds in isolated rat aorta.
    Pharmacological research, 2006, Volume: 54, Issue:2

    Topics: Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Harmaline; Harmine; In Vitro Techniques; Molecular Structure; Muscle, Smooth, Vascular; Peganum; Plant Extracts; Rats; Rats, Wistar; Seeds; Vasodilation; Vasodilator Agents

2006
Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:7

    Topics: Adult; Antioxidants; Cholesterol, LDL; Dose-Response Relationship, Drug; Harmaline; Harmine; Humans; In Vitro Techniques; Kinetics; Lipid Peroxides; Oxidation-Reduction; Peganum; Plant Extracts; Seeds

2006
Effects of beta-carboline alkaloids on the object recognition task in mice.
    Life sciences, 2006, Oct-26, Volume: 79, Issue:22

    Topics: Alkaloids; Animals; Carbolines; Harmaline; Harmine; Injections, Intraperitoneal; Male; Mice; Models, Animal; Recognition, Psychology

2006
A study on the antitumoral and differentiation effects of peganum harmala derivatives in combination with ATRA on leukaemic cells.
    Archives of pharmacal research, 2007, Volume: 30, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Cell Differentiation; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Granulocyte Colony-Stimulating Factor; Harmaline; Harmine; HL-60 Cells; Humans; Peganum; Recombinant Proteins; Tretinoin

2007
Cytotoxicity of the beta-carboline alkaloids harmine and harmaline in human cell assays in vitro.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2008, Volume: 60, Issue:4-5

    Topics: Adult; Cell Death; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Central Nervous System Stimulants; Female; Harmaline; Harmine; Humans; In Vitro Techniques; Male; Micronucleus Tests

2008
Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities.
    Journal of natural medicines, 2008, Volume: 62, Issue:4

    Topics: Alkaloids; Animals; Antimalarials; Harmaline; Harmine; Peganum; Phenylephrine; Plant Extracts; Plasmodium falciparum; Quinazolines; Rats; Seeds; Vasodilation; Vasodilator Agents

2008
Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:11

    Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Bacteria; Carbolines; Chickens; Drug Resistance; Eukaryota; Harmaline; Harmine; Microbial Sensitivity Tests; Parasitic Sensitivity Tests; Peganum; Phytotherapy; Plant Extracts; Plants, Medicinal

2008
Separation and purification of harmine and harmaline from Peganum harmala using pH-zone-refining counter-current chromatography.
    Journal of separation science, 2008, Volume: 31, Issue:20

    Topics: Countercurrent Distribution; Harmaline; Harmine; Hydrogen-Ion Concentration; Molecular Structure; Monoamine Oxidase Inhibitors; Peganum; Solvents

2008
Ayahuasca versus violence--a case report.
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2008, Volume: 10, Issue:2

    Topics: Administration, Oral; Adult; Antisocial Personality Disorder; Banisteriopsis; Catharsis; Crisis Intervention; Drug Users; Harmaline; Harmine; Homicide; Humans; Impulsive Behavior; Male; Monoamine Oxidase Inhibitors; Morals; N,N-Dimethyltryptamine; Phytotherapy; Plant Preparations; Selective Serotonin Reuptake Inhibitors; Violence

2008
Floral nectar composition of Peganum harmala L.
    Natural product research, 2009, Volume: 23, Issue:3

    Topics: Chromatography, High Pressure Liquid; Flowers; Fructose; Glucose; Harmaline; Harmine; Peganum; Sucrose

2009
Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas ligand interaction in human lung carcinoma H596 cells.
    Anti-cancer drugs, 2009, Volume: 20, Issue:5

    Topics: Adenocarcinoma; Apoptosis; Carcinoma, Adenosquamous; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Enzyme Activation; Fas Ligand Protein; fas Receptor; Harmaline; Harmine; Humans; Lung Neoplasms; Neoplasm Proteins

2009
beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO).
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:3

    Topics: Carbolines; Chromatography, High Pressure Liquid; Harmaline; Harmine; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peganum; Plant Extracts; Plant Roots; Seeds; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet

2010
Composition, standardization and chemical profiling of Banisteriopsis caapi, a plant for the treatment of neurodegenerative disorders relevant to Parkinson's disease.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Alkaloids; Animals; Banisteriopsis; Beverages; Biflavonoids; Catechin; Ethnopharmacology; Harmaline; Harmine; Humans; Monoamine Oxidase; Neurodegenerative Diseases; Parkinson Disease; Plant Leaves; Plant Stems; Plants; Proanthocyanidins; Reference Standards; Superoxide Dismutase

2010
Beta-carboline alkaloids bind DNA.
    Journal of photochemistry and photobiology. B, Biology, 2010, Aug-02, Volume: 100, Issue:2

    Topics: Animals; Antineoplastic Agents; Binding Sites; Carbolines; Cattle; DNA; Harmaline; Harmine; Intercalating Agents; Nucleic Acid Conformation; Peganum; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared

2010
Interaction of β-carboline alkaloids with RNA.
    DNA and cell biology, 2010, Volume: 29, Issue:12

    Topics: Carbolines; Harmaline; Harmine; Nucleic Acid Conformation; Peganum; Plants, Medicinal; RNA, Fungal

2010
Mitochondrial dysfunction and biotransformation of β-carboline alkaloids, harmine and harmaline, on isolated rat hepatocytes.
    Chemico-biological interactions, 2010, Dec-05, Volume: 188, Issue:3

    Topics: Animals; Biotransformation; Cell Respiration; Glutathione; Glutathione Disulfide; Hallucinogens; Harmaline; Harmine; Hepatocytes; Male; Malondialdehyde; Mitochondria; Mitochondrial Membranes; Nitrophenols; Permeability; Rats; Sulfhydryl Compounds

2010
Screening of medicinal plants from Iranian traditional medicine for acetylcholinesterase inhibition.
    Phytotherapy research : PTR, 2011, Volume: 25, Issue:8

    Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Drug Evaluation, Preclinical; Harmaline; Harmine; Iran; Medicine, Traditional; Peganum; Plant Extracts; Plants, Medicinal; Seeds

2011
Harmine is a potent antimalarial targeting Hsp90 and synergizes with chloroquine and artemisinin.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:8

    Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Synergism; Harmaline; Harmine; HSP90 Heat-Shock Proteins; Malaria; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Plasmodium berghei; Plasmodium falciparum; Protein Structure, Quaternary; Protein Structure, Tertiary; Surface Plasmon Resonance

2012
Metabolic pathways of the psychotropic-carboline alkaloids, harmaline and harmine, by liquid chromatography/mass spectrometry and NMR spectroscopy.
    Food chemistry, 2012, Sep-15, Volume: 134, Issue:2

    Topics: Animals; Banisteriopsis; Carbolines; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Harmaline; Harmine; Humans; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Peganum; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Urine

2012
Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops.
    Molecules (Basel, Switzerland), 2013, Feb-27, Volume: 18, Issue:3

    Topics: Alkaloids; Crops, Agricultural; Harmaline; Harmine; Herbicides; Peganum; Pheromones; Plant Extracts; Seeds

2013
Harmine and harmaline downregulate TCDD-induced Cyp1a1 in the livers and lungs of C57BL/6 mice.
    BioMed research international, 2013, Volume: 2013

    Topics: Animals; Cytochrome P-450 CYP1A1; Environmental Pollutants; Gene Expression Regulation, Enzymologic; Harmaline; Harmine; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Microsomes; Polychlorinated Dibenzodioxins

2013
Simultaneous determination of harmine, harmaline and their metabolites harmol and harmalol in beagle dog plasma by UPLC-ESI-MS/MS and its application to a pharmacokinetic study.
    Journal of pharmaceutical and biomedical analysis, 2013, Volume: 85

    Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Female; Harmaline; Harmine; Male; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2013
Fast determination of harmala alkaloids in edible algae by capillary electrophoresis mass spectrometry.
    Analytical and bioanalytical chemistry, 2015, Volume: 407, Issue:13

    Topics: Electrophoresis, Capillary; Food Analysis; Harmaline; Harmine; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Undaria

2015
Harmaline and hispidin from Peganum harmala and Inonotus hispidus with binding affinity to Candida rugosa lipase: In silico and in vitro studies.
    Bioorganic chemistry, 2015, Volume: 62

    Topics: Antioxidants; Basidiomycota; Candida; Enzyme Inhibitors; Fungal Proteins; Harmaline; Harmine; Lactones; Lipase; Molecular Docking Simulation; Orlistat; Peganum; Pyrones

2015
A rapid and simple method for the determination of psychoactive alkaloids by CE-UV: application to Peganum Harmala seed infusions.
    Drug testing and analysis, 2017, Volume: 9, Issue:4

    Topics: Alkaloids; Carbolines; Electrophoresis, Capillary; Harmaline; Harmine; Limit of Detection; Monoamine Oxidase Inhibitors; Peganum; Plant Extracts; Psychotropic Drugs; Seeds; Time Factors

2017
Interspecies metabolic diversity of harmaline and harmine in in vitro 11 mammalian liver microsomes.
    Drug testing and analysis, 2017, Volume: 9, Issue:5

    Topics: Animals; Camelus; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dogs; Hallucinogens; Harmaline; Harmine; Humans; Metabolome; Mice; Microsomes, Liver; Rabbits; Rats; Sheep; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Swine; Tandem Mass Spectrometry

2017
Short Communication: Evaluation of antimicrobial activities of Harmine, Harmaline, Nicotine and their complexes.
    Pakistan journal of pharmaceutical sciences, 2016, Volume: 29, Issue:4

    Topics: Anti-Infective Agents; Harmaline; Harmine; Nicotine

2016
Microwave-assisted extraction of three bioactive alkaloids from Peganum harmala L. and their acaricidal activity against Psoroptes cuniculi in vitro.
    Journal of ethnopharmacology, 2016, Nov-04, Volume: 192

    Topics: Acaricides; Alkaloids; Animals; Chemical Fractionation; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Dose-Response Relationship, Drug; Harmaline; Harmine; Hot Temperature; Microwaves; Parasitic Sensitivity Tests; Peganum; Phytotherapy; Plant Extracts; Plants, Medicinal; Psoroptidae; Quinazolines; Seeds; Time Factors; Ultrasonics

2016
Antitrichomonal activity of Peganum harmala alkaloid extract against trichomoniasis in pigeon (Columba livia domestica).
    British poultry science, 2017, Volume: 58, Issue:3

    Topics: Animals; Antitrichomonal Agents; Bird Diseases; Columbidae; Harmaline; Harmine; Metronidazole; Peganum; Plant Extracts; Trichomonas; Trichomonas Infections

2017
The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro.
    Scientific reports, 2017, 07-13, Volume: 7, Issue:1

    Topics: Alkaloids; Animals; Banisteriopsis; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Harmaline; Harmine; Mice; Neural Stem Cells; Neurogenesis; Neuroprotective Agents

2017
Mechanism-based pharmacokinetics-pharmacodynamics studies of harmine and harmaline on neurotransmitters regulatory effects in healthy rats: Challenge on monoamine oxidase and acetylcholinesterase inhibition.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 62

    Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain; Carbolines; Cholinesterase Inhibitors; Chromatography, Liquid; Endothelial Cells; Harmaline; Harmine; Humans; Male; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rats; Tandem Mass Spectrometry

2019
Validation of an analytical method for the determination of the main ayahuasca active compounds and application to real ayahuasca samples from Brazil.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2019, Aug-15, Volume: 1124

    Topics: Banisteriopsis; Beverages; Brazil; Chromatography, High Pressure Liquid; Harmaline; Harmine; Mass Spectrometry; N,N-Dimethyltryptamine; Plant Preparations

2019
Light-induced full aromatization and hydroxylation of 7-methoxy-1-methyl-3,4-dihydro-2H-pyrido[3,4-b]indole alkaloid: Oxygen partial pressure as a key modulator of the photoproducts distribution.
    Journal of photochemistry and photobiology. B, Biology, 2019, Volume: 199

    Topics: Alkaloids; Carbolines; Harmaline; Harmine; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxylation; Indoles; Light; Multivariate Analysis; Oxygen; Partial Pressure; Photochemical Processes; Reactive Oxygen Species; Singlet Oxygen; Structure-Activity Relationship

2019
Pilot study on the uptake and modification of harmaline in acceptor plants: An innovative approach to visualize the interspecific transfer of natural products.
    Phytochemistry, 2020, Volume: 174

    Topics: Biological Products; Harmaline; Harmine; Peganum; Pilot Projects

2020
A rapid analytical strategy for the determination of ayahuasca alkaloids in non-ritualistic approaches by UHPLC-MS/MS.
    Forensic science international, 2020, Volume: 312

    Topics: Banisteriopsis; Beverages; Chromatography, High Pressure Liquid; Drug Trafficking; Hallucinogens; Harmaline; Harmine; Humans; Illicit Drugs; N,N-Dimethyltryptamine; Tandem Mass Spectrometry

2020
In-silico Prediction of the Beta-carboline Alkaloids Harmine and Harmaline as Potent Drug Candidates for the Treatment of Parkinson's disease.
    Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2021, Volume: 20, Issue:3

    Topics: Alkaloids; Carbolines; Harmaline; Harmine; Humans; Molecular Docking Simulation; Neurodegenerative Diseases; Parkinson Disease

2021
Hispidin, Harmaline, and Harmine as potent inhibitors of bovine xanthine oxidase: Gout treatment, in vitro, ADMET prediction, and SAR studies.
    Bioorganic chemistry, 2021, Volume: 112

    Topics: Animals; Cattle; Dose-Response Relationship, Drug; Enzyme Inhibitors; Harmaline; Harmine; Molecular Docking Simulation; Molecular Structure; Pyrones; Structure-Activity Relationship; Xanthine Oxidase

2021
UV-light-driven photooxidation of harmaline catalyzed by riboflavin: Product characterization and mechanisms.
    Fitoterapia, 2021, Volume: 155

    Topics: Carbolines; Cell Line, Tumor; Harmaline; Harmine; Humans; Molecular Structure; Neuroprotective Agents; Oxidation-Reduction; Riboflavin; Ultraviolet Rays

2021
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine.
    Chinese journal of natural medicines, 2022, Volume: 20, Issue:3

    Topics: Animals; Harmaline; Harmine; Heme; Hydrogen Peroxide; Rats; Tandem Mass Spectrometry

2022
Innovative spectrofluorometric method for determination of harmaline and harmine in different matrices.
    Scientific reports, 2023, Nov-15, Volume: 13, Issue:1

    Topics: Alkaloids; Harmaline; Harmine; Humans; Peganum; Plant Extracts

2023