Compounds > hapalosin
Page last updated: 2024-09-04

hapalosin and verapamil

hapalosin has been researched along with verapamil in 3 studies

*Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent. [MeSH]

*Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent. [MeSH]

Compound Research Comparison

Studies
(hapalosin)		Trials
(hapalosin)		Recent Studies (post-2010)
(hapalosin)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
100217,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomyhapalosin (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Armstrong, RW; Dinh, TQ; Du, X; Smith, CD1
Littlefield, BA; Meng, Z; O'Connell, CE; Salvato, KA; Schwartz, CE1
Kashihara, N; Nakamura, K; Nishiyama, S; To-e, S; Umezawa, K; Yamamura, S1

Other Studies

3 other study(ies) available for hapalosin and verapamil

ArticleYear
Design, synthesis, and evaluation of the multidrug resistance-reversing activity of D-glucose mimetics of hapalosin.
    Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Survival; Depsipeptides; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glucose; Humans; Lactams; Lactones; Molecular Mimicry; Multidrug Resistance-Associated Proteins; Tumor Cells, Cultured

1998
Synthesis and evaluation of hapalosin and analogs as MDR-reversing agents.
    Bioorganic & medicinal chemistry letters, 1999, Jun-07, Volume: 9, Issue:11

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Depsipeptides; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; Lactams; Lactones; Mice; Models, Chemical; Recombinant Proteins; Tumor Cells, Cultured

1999
Synthesis and biological activities of hapalosin derivatives with modification at the C12 position.
    Bioorganic & medicinal chemistry letters, 2000, Jan-17, Volume: 10, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Depsipeptides; Drug Resistance, Multiple; Lactams; Lactones; Models, Molecular; Molecular Conformation; Molecular Structure; Peptides, Cyclic; Protein Conformation; Tumor Cells, Cultured; Vincristine

2000