halothane and phenobarbital

halothane has been researched along with phenobarbital in 129 studies

Research

Studies (129)

Timeframe	Studies, this research(%)	All Research%
pre-1990	115 (89.15)	18.7374
1990's	11 (8.53)	18.2507
2000's	2 (1.55)	29.6817
2010's	1 (0.78)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abraham, MH; Acree, WE; Ibrahim, A	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Uehleke, H; Werner, T	1
Frimmer, M; Homann, J; Rufeger, U	1
Blitt, CD; Brown, BR; Gandolfi, AJ; Sipes, IG; Wright, BJ	1
Berman, MC; Ivanetich, KM; Kench, JE	1
Grumley, JO; Rao, GS	1
Appel, KE; Kunz, HW; Rickart, R; Schwarz, M	1
Cascorbi, HF; Gorsky, BH	1
Brown, BR; McLain, GE; Sipes, IG	1
Cardell, RR; Daggy, BP; Ross, WT	1
Huck, S	1
Biltz, H; Siegers, CP; Wächter, S	1
Brown, BR; Podolsky, TL; Sipes, IG	1
Hitt, BA; Mazze, RI	1
Hägerdal, M; Harp, JR; Keykhah, MM; Perez, E; Welsh, FA	1
Cohen, EN; Kendig, JJ; Schneider, TM	1
Rao, GS	1
Bielicki, L; Krieglstein, J	1
Furukawa, T; Hirokata, Y; Karashima, D; Shigematsu, A	1
Ford, EJ; Gopinath, G	1
Turnbull, MJ; Watkins, JW	1
Evans, DE	1
Moslen, MT; Reynolds, ES	2
Gandolfi, AJ; Van Dyke, RA; Widger, LA	1
Chopp, M; Li, Y; Marsh, HM; Mostafapour, S; Van Dyke, RA	1
Aeschlimann, D; Christen, U; Gut, J; Huwyler, J	1
Baker, MT; Chiang, CK; Vasquez, MT	1
Cazzaro, S; Manno, M; Rezzadore, M	1
Becker, GL	1
Johnson, JT; Olson, MJ; Reidy, CA	1
Bastian, C	1
Patial, RK; Patial, SB; Sarin, R	1
Klessen, C; Witt, M	1
Heger, B; Siegers, CP; Wilhelm, KP; Younes, M	1
Albrecht, RF; Baughman, VL; Hoffman, WE; Miletich, DJ	1
Cousins, MJ; Gourlay, GK; Knights, KM	1
Berman, LM; Harbison, RD; James, RC; Roberts, SM; Smith, AC	1
Cousins, MJ; Gibson, RA; Gourlay, GK; Knights, KM	1
Cmielewski, PL; Cousins, MJ; Hall, PD; Ilsley, AH; Jenner, MA; Plummer, JL	1
Costa, AK; Heffel, DF; Schieble, TM; Trudell, JR	1
Eger, EI; Johnson, BH; Koblin, DD; Konopka, K; Waskell, L	1
Gruenke, LD; Konopka, K; Koop, DR; Waskell, LA	1
Albrecht, RF; Becker, GL; Miletich, DJ	1
Eger, EI; Ferrell, LD; Johnson, BH; Strum, DP	1
Gelman, S	1
Brown, BR; Gandolfi, AJ; Lind, RC; Sipes, IG; Waters, SJ	1
Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ	1
Cornell, K; Erwin, VG; Zgombick, JM	1
Cahalan, MK; Eger, EI; Eger, RR; Fassoulaki, A; Ferrell, LD; Harper, MH; Johnson, BH; Smuckler, EA	2
Cousins, MJ; Hall, PM; Jenner, MA; Plummer, JL	1
Brown, BR; Gandolfi, AJ; Lind, RC; Sipes, IG	1
Abd el-Hady, SL; Atallah, MM; el-Serafy, AK; Mowafy, TK	2
Adam, SE; Ford, EJ; Gopinath, C	1
Van Dyke, RA; Wood, CL	1
Harrison, GG; Smith, JS	1
Halsey, MJ	1
Rösen, P; Stier, A	1
Mansuy, D; Nastainczyk, W; Ullrich, V	1
Clarke, KW; Hall, LW	1
Kunz, W; Schaude, G; Thomas, C	1
Fink, BR; Kenny, GE; Simpson, WE	1
Davis, DC; Gillette, JR; Gram, TE; Reagan, RL; Schroeder, DH	1
Brown, BR	1
Cascorbi, HF; Singh-Amaranath, AV	1
Brown, BR; Sagalyn, AM; Sipes, IG	1
Falcetti, JP; Greene, NM	1
Cohen, AB; Rosenthal, WS; Stenger, RJ	1
Van Dyke, RA	2
Greene, NM	1
Bianchi, L; Ohnacker, H	1
Takahashi, S	1
Barth, ML; Cornish, HH	1
Fiserova-Bergerova, V	1
MacMillan, V; Siesjö, BK	1
Faupel, RP; Kampf, SC; Seitz, HJ; Tarnowski, W	1
Korten, K; Van Dyke, RA	1
Bischoff, D; Dreyer, C; Göthert, M	1
Furukawa, T; Shigematsu, A; Takahashi, S	1
Abe, H; Okuda, K	1
Niessing, J; Schaude, G; Siess, M; Vogell, W	1
Brown, RE; DiFazio, C	1
Messeter, K; Pontén, U; Siesjö, BK	1
Johnson, EA; Stenger, RJ	1
Ahnefeld, FW; Beneke, G; Gostomzyk, JG; Paulini, K	1
Jessen, K; Rosendal, T	1
Almersjö, O	1
Clauberg, G	2
Karczewska, E	1
Schmiedeberg, W; Thiel, HJ; van Zwieten, PA	1
Goldman, V	1
Kudo, T; Matusmoto, F; Oyama, T; Shibata, S; Takiguchi, M	1
Dickerson, G	1
Ficor, F; Fujii, K; Ishihara, S; Kikuchi, H; Morio, M; Okida, M	1
Carlson, GP; White, JF	1
Frühling, A; Siegers, CP; Younes, M	2
Eger, EI; Johnson, BH; Lurz, FW; Shingu, K; Taber, V	1
Bishop, SP; Bradley, EL; Fowler, KC; Gelman, S; Rimerman, V	1
Duffy, SW; Monk, SJ; Ross, JA	1
Brown, BR; Gandolfi, AJ; Jee, RC; Sipes, IG	1
Fujii, K; Miki, N; Miyake, Y; Morio, M; Sugiyama, T; Yamano, T	1
Abbott, WM; Cambria, RP; L'Italien, G; Megerman, J; Strauss, HW; Warnock, D	1
Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M	1
Poppers, PJ	1
Biava, C; Collins, P; Eger, EI; Harper, MH; Johnson, B	1
Bösterling, B; Trevor, AJ; Trudell, JR	1
de Groot, H; Harnisch, U; Noll, T	1
Chang, KS; Shires, TK	1
Müller, R; Stier, A	1
Scholfield, CN	1
Daggy, BP; Ross, WT	1
Adams, JF; Cousins, MJ; Gourlay, GK; Hall, P	1
Gandolfi, AJ; Sipes, IG	1
Adams, JF; Cousins, MJ; Gourlay, GK; Sharp, JH	1
Anders, MW; Kubic, VL	1
Lin, WQ; Marsh, HM; Trudell, JR; Van Dyke, RA	1
Gut, J; Huwyler, J	1
Baker, MT; Olson, MJ; Wang, Y	1
Awad, JA; Franks, JJ; Horn, JL; Roberts, LJ	1
Chow, T; Funae, Y; Hiroi, T; Imaoka, S	1
BENTLEY, HB	1

Reviews

4 review(s) available for halothane and phenobarbital

Article	Year
Biotransformation of volatile anaesthetics with special emphasis on the role of metabolism in the toxicity of anaesthetics. Canadian Anaesthetists' Society journal, 1973, Volume: 20, Issue:1 Topics: Anesthesia, Inhalation; Anesthetics; Animals; Biotransformation; Chloroform; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethyl Ethers; Halothane; Humans; Kidney; Liver; Liver Circulation; Methoxyflurane; Oxalates; Phenobarbital; Rats	1973
Halothane anesthesia and hepatitis in a high-risk population. The New England journal of medicine, 1973, Aug-09, Volume: 289, Issue:6 Topics: Chemical and Drug Induced Liver Injury; Chlorpromazine; Diazepam; Enzyme Induction; Halothane; Humans; Liver; Microsomes, Liver; Phenobarbital; Phenytoin; Postoperative Complications; Reserpine; Thioridazine; Time Factors	1973
[Recent progress in the study of liver diseases]. Naika. Internal medicine, 1971, Volume: 27, Issue:1 Topics: Adrenal Cortex Hormones; Anesthesia, Inhalation; Bilirubin; Biological Transport; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; Hepatitis; Hepatitis B Antigens; Hepatitis B virus; Humans; Liver; Liver Diseases; Liver Neoplasms; Phenobarbital	1971
Hepatic drug metabolism and anesthesia. Der Anaesthesist, 1980, Volume: 29, Issue:2 Topics: Acute Kidney Injury; Anesthetics; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorides; Halothane; Humans; Liver; Methoxyflurane; Methylcholanthrene; Phenobarbital	1980

Other Studies

125 other study(ies) available for halothane and phenobarbital

Article	Year
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
A comparative study on the irreversible binding of labeled halothane trichlorofluoromethane, chloroform, and carbon tetrachloride to hepatic protein and lipids in vitro and in vivo. Archives of toxicology, 1975, Dec-18, Volume: 34, Issue:4 Topics: 1-Propanol; Aerobiosis; Age Factors; Anaerobiosis; Animals; Carbon Tetrachloride; Chloroform; Cobalt; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Halothane; Humans; In Vitro Techniques; Lipid Metabolism; Liver; Methylcholanthrene; Mice; Microsomes, Liver; Mitochondria, Liver; NADP; Phenobarbital; Protein Binding; Rabbits; Rats; Species Specificity	1975
[Inhibition by diethyldithiocarbamate (DEDTC) of acute hepatotoxic effects induced by polyhalogenated hydrocarbons (PHHC)]. Der Anaesthesist, 1976, Volume: 25, Issue:3 Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Ditiocarb; Glutathione; Halothane; Hydrocarbons, Halogenated; Liver Diseases; Male; Microcirculation; Perfusion; Phenobarbital; Rats; Thiocarbamates; Trichloroethylene	1976
Pulmonary biotransformation of methoxyflurane: an in-vitro study in the rabbit. Anesthesiology, 1979, Volume: 51, Issue:6 Topics: Animals; Biotransformation; Cytochrome c Group; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Female; Halothane; Lung; Male; Methoxyflurane; Microsomes; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Rabbits	1979
The effects of halothane on hepatic microsomal electron transfer. The Biochemical journal, 1975, Volume: 148, Issue:2 Topics: Animals; Carbon Monoxide; Cyanides; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Electron Transport; Electron Transport Complex IV; Halothane; Male; Microsomes, Liver; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Phenobarbital; Rats; Stearoyl-CoA Desaturase	1975
Extrahepatic tissue distribution, covalent binding, and toxicity of halothane in control and phenobarbital-pretreated rats. Pharmacology and therapeutics in dentistry, 1978, Volume: 3, Issue:2-4 Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Kidney; Liver; Lung; Male; Necrosis; Phenobarbital; Protein Binding; Rats	1978
Effect of DMN, phenobarbital and halothane on the sedimentation characteristics of rat liver DNA. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1979, Issue:2 Topics: Animals; Centrifugation, Density Gradient; Dimethylnitrosamine; DNA; Halothane; Hepatectomy; Liver; Male; Nitrosamines; Phenobarbital; Rats	1979
Halothane hepatotoxicity and fluoride production in mice and rats. Anesthesiology, 1979, Volume: 50, Issue:2 Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fluorides; Halothane; Hypoxia; Male; Mice; Oxygen; Phenobarbital; Rats; Species Specificity; Thiopental	1979
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. Anesthesiology, 1979, Volume: 51, Issue:4 Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Fluorides; Glutathione; Halothane; Hypoxia; Injections, Intraperitoneal; Lipid Metabolism; Liver; Liver Circulation; Male; Microsomes, Liver; Necrosis; Phenobarbital; Rats	1979
Hepatic necrosis caused by halothane and hypoxia in phenobarbital-treated rats. Anesthesiology, 1979, Volume: 51, Issue:4 Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorides; Glutathione; Halothane; Hypoxia; Liver; Male; Microsomes, Liver; Necrosis; Phenobarbital; Rats	1979
The estimation of the survival rate of tetanus-intoxicated mice. A model for screening anti-tetanus drugs. Naunyn-Schmiedeberg's archives of pharmacology, 1979, Volume: 308, Issue:1 Topics: Animals; Chlorpromazine; Diazepam; Drug Evaluation, Preclinical; Halothane; Male; Mice; Phenobarbital; Seizures; Tetanus; Tetanus Antitoxin; Tetanus Toxin; Time Factors	1979
[The influence of ethanol, dithiocarb, diethylmaleate and phenobarbital on the metabolic elimination of halothane in rats (author's transl)]. Der Anaesthesist, 1979, Volume: 28, Issue:8 Topics: Animals; Ethanol; Halothane; Maleates; Metabolic Clearance Rate; Phenobarbital; Rats; Thiocarbamates	1979
Bioactivation and covalent binding of halothane to liver macromolecules. Environmental health perspectives, 1977, Volume: 21 Topics: Animals; Aroclors; DNA; Halothane; Liver; Microsomes, Liver; Phenobarbital; Phospholipids; Protein Binding; Proteins; Rats	1977
Effect of enzyme induction on nephrotoxicity of halothane-related compounds. Environmental health perspectives, 1977, Volume: 21 Topics: Anesthetics; Animals; Biotransformation; Enflurane; Environmental Exposure; Enzyme Induction; Fluorides; Halothane; Humans; Isoflurane; Kidney Diseases; Methoxyflurane; Phenobarbital; Rats	1977
Protective effects of combinations of hypothermia and barbiturates in cerebral hypoxia in the rat. Anesthesiology, 1978, Volume: 49, Issue:3 Topics: Animals; Brain; Carotid Arteries; Glucose; Halothane; Hypothermia, Induced; Hypoxia; Lactates; Ligation; Male; Phenobarbital; Rats	1978
Anesthetics inhibit pressure-induced repetitive impulse generation. Journal of applied physiology: respiratory, environmental and exercise physiology, 1978, Volume: 45, Issue:5 Topics: Action Potentials; Animals; Astacoidea; Atmospheric Pressure; Axons; Ethanol; Halothane; In Vitro Techniques; Phenobarbital	1978
A study of the mechanism of halothane-induced liver necrosis. Role of covalent binding of halothane metabolites to liver proteins in the rat. Journal of medicinal chemistry, 1977, Volume: 20, Issue:2 Topics: Alanine Transaminase; Animals; DNA; Drug Interactions; Halothane; In Vitro Techniques; Lipid Metabolism; Liver; Male; Necrosis; Phenobarbital; Protein Binding; Proteins; Rats; Time Factors	1977
The effect of anesthesia on brain mitochondrial hexokinase. Naunyn-Schmiedeberg's archives of pharmacology, 1977, Volume: 298, Issue:3 Topics: Anesthesia; Animals; Brain; Halothane; Hexokinase; In Vitro Techniques; Male; Mitochondria; Pentylenetetrazole; Phenobarbital; Rats; Solubility	1977
The in vitro metabolism of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by hepatic microsomal cytochrome P-450. The Journal of pharmacology and experimental therapeutics, 1977, Volume: 203, Issue:2 Topics: Animals; Chromatography, Gas; Cytochrome P-450 Enzyme System; Halothane; In Vitro Techniques; Male; Microsomes, Liver; Phenobarbital; Rabbits; Trifluoroacetic Acid	1977
The influence of hepatic microsomal amidopyrine demethylase activity on halothane hepatotoxicity in the horse. The Journal of pathology, 1976, Volume: 119, Issue:2 Topics: Aminopyrine N-Demethylase; Animals; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Chlorpromazine; DDT; Halothane; Horses; Liver; Microsomes, Liver; Necrosis; Phenobarbital	1976
Determination of halothane-induced sleeping time in the rat: effect of prior administration of centrally active drugs. British journal of pharmacology, 1976, Volume: 58, Issue:1 Topics: Animals; Bemegride; Brain Chemistry; Circadian Rhythm; Drug Interactions; Female; Halothane; Injections, Intraventricular; Liver; Pentobarbital; Phenobarbital; Proadifen; Rats; Seizures; Sleep; Time Factors	1976
Anaesthesia and the epileptic pateint. A review. Anaesthesia, 1975, Volume: 30, Issue:1 Topics: Adult; Anesthesia, General; Anticonvulsants; Barbiturates; Central Nervous System; Child, Preschool; Drug Interactions; Electroencephalography; Enzyme Induction; Epilepsy; Female; Halothane; Humans; Inactivation, Metabolic; Ketamine; Male; Methohexital; Nitrous Oxide; Phenobarbital; Phenytoin; Protein Binding	1975
Metabolism of (14C-1)-halothane in vivo--effects of multiple halothane anesthesia, phenobarbital and carbon tetrachloride pretreatment. Biochemical pharmacology, 1975, Nov-15, Volume: 24, Issue:22 Topics: Anesthesia; Animals; Carbon Tetrachloride; Halothane; Liver; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Respiration; Time Factors	1975
Hypoxia and halothane metabolism in vivo: release of inorganic fluoride and halothane metabolite binding to cellular constituents. Anesthesiology, 1976, Volume: 44, Issue:3 Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Halothane; Hypoxia; Lipid Metabolism; Liver; Male; Microsomes, Liver; Oxygen; Partial Pressure; Phenobarbital; Protein Binding; Rats	1976
Immunocytochemical detection of the 72-kDa heat shock protein in halothane--induced hepatotoxicity in rats. Life sciences, 1992, Volume: 50, Issue:7 Topics: Animals; Antibodies, Monoclonal; Chemical and Drug Induced Liver Injury; Halothane; Heat-Shock Proteins; Immunoenzyme Techniques; Liver; Liver Diseases; Male; Phenobarbital; Rats; Rats, Inbred Strains	1992
The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane. European journal of biochemistry, 1992, Jul-01, Volume: 207, Issue:1 Topics: Animals; Cell Fractionation; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Chlorofluorocarbons, Methane; Halothane; Hydrocarbons, Halogenated; Kidney; Liver; Male; Microsomes; Microsomes, Liver; Phenobarbital; Protein Binding; Proteins; Rats; Rats, Inbred Strains	1992
Evidence for the stability and cytochrome P450 specificity of the phenobarbital-induced reductive halothane-cytochrome P450 complex formed in rat hepatic microsomes. Biochemical pharmacology, 1991, Jun-01, Volume: 41, Issue:11 Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Halothane; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Warfarin	1991
The mechanism of the suicidal reductive inactivation of microsomal cytochrome P-450 by halothane. Archives of toxicology, 1991, Volume: 65, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Halothane; Kinetics; Male; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Spectrum Analysis	1991
Fatty acid lessens halothane's inhibition of energy metabolism in isolated hepatocytes. Anesthesia and analgesia, 1990, Volume: 70, Issue:1 Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Energy Metabolism; Halothane; In Vitro Techniques; Liver; Male; Oleic Acid; Oleic Acids; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred F344	1990
Defluorination of 1,1,1,2-tetrafluoroethane (R-134a) by rat hepatocytes. Biochemical and biophysical research communications, 1990, Feb-14, Volume: 166, Issue:3 Topics: Animals; Biotransformation; Cells, Cultured; Halothane; Hydrocarbons, Fluorinated; Kinetics; Liver; Male; Oxidation-Reduction; Phenobarbital; Potentiometry; Rats; Rats, Inbred F344	1990
The effect of halothane, enflurane, and isoflurane on RNA synthesis in isolated rat liver cell nuclei. Anesthesia and analgesia, 1988, Volume: 67, Issue:6 Topics: Administration, Inhalation; Animals; Cell Nucleus; Enflurane; Female; Halothane; Isoflurane; Liver; Phenobarbital; Rats; Rats, Inbred Strains; RNA; RNA Polymerase I; RNA Polymerase II; Transcription, Genetic	1988
Halothane associated hepatitis and phenobarbitone. The Journal of the Association of Physicians of India, 1989, Volume: 37, Issue:7 Topics: Adult; Anesthesia, Obstetrical; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Halothane; Hepatic Encephalopathy; Humans; Obesity; Phenobarbital	1989
Lectin binding sites in normal and phenobarbitale/halothane treated rat liver. A histochemical study. Histochemistry, 1989, Volume: 90, Issue:5 Topics: Animals; Bile Canaliculi; Binding Sites; Glycoconjugates; Halothane; Histocytochemistry; Kupffer Cells; Lectins; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1989
Enhanced in vivo-lipid peroxidation associated with halothane hepatotoxicity in rats. Pharmacology & toxicology, 1988, Volume: 63, Issue:1 Topics: Animals; Catechin; Deferoxamine; Ditiocarb; Glutathione; Halothane; Lipid Peroxides; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1988
Effects of phenobarbital on cerebral blood flow and metabolism in young and aged rats. Anesthesiology, 1986, Volume: 65, Issue:5 Topics: Aging; Anesthesia, Inhalation; Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Depression, Chemical; Dose-Response Relationship, Drug; Electroencephalography; Halothane; Injections, Intraperitoneal; Nitrous Oxide; Oxygen; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred Strains	1986
Changes in rat hepatic microsomal mixed function oxidase activity following exposure to halothane under various oxygen concentrations. Biochemical pharmacology, 1987, Mar-15, Volume: 36, Issue:6 Topics: Alanine Transaminase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Halothane; Hypoxia; Kinetics; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Ornithine Carbamoyltransferase; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Rats, Inbred F344	1987
Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats. Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:8 Topics: Animals; Chemical and Drug Induced Liver Injury; Glutathione; Halothane; Hyperthyroidism; Lipid Metabolism; Male; Microsomes, Liver; NADP; Phenobarbital; Proteins; Pyridines; Rats; Rats, Inbred Strains; Triiodothyronine	1988
Halothane induced hepatic necrosis in rats: the role of in vivo lipid peroxidation. Pharmacology & toxicology, 1988, Volume: 63, Issue:5 Topics: Alanine Transaminase; Animals; Fatty Acids; Halothane; Lipid Metabolism; Lipid Peroxidation; Liver; Male; Microsomes, Liver; Necrosis; Phenobarbital; Rats; Rats, Inbred F344	1988
Effects of treatment with phenobarbitone or isoniazid on hepatotoxicity due to prolonged subanaesthetic halothane inhalation. Pharmacology & toxicology, 1988, Volume: 62, Issue:2 Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Halothane; Isoniazid; Liver; Male; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; Time Factors	1988
Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes. Anesthesiology, 1988, Volume: 68, Issue:4 Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Halothane; Hypoxia; In Vitro Techniques; Isoflurane; Liver; Male; Phenobarbital; Rats	1988
I-653 resists degradation in rats. Anesthesia and analgesia, 1988, Volume: 67, Issue:6 Topics: Anesthetics; Animals; Biotransformation; Desflurane; Drug Interactions; Ethanol; Fluorides; Halothane; Isoflurane; Methoxyflurane; Phenobarbital; Rats; Rats, Inbred Strains	1988
Characterization of halothane oxidation by hepatic microsomes and purified cytochromes P-450 using a gas chromatographic mass spectrometric assay. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:2 Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Fluoroacetates; Gas Chromatography-Mass Spectrometry; Halothane; Humans; Imidazoles; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rabbits; Trifluoroacetic Acid	1988
Halogenated anesthetics increase oxygen consumption in isolated hepatocytes from phenobarbital-treated rats. Anesthesiology, 1987, Volume: 67, Issue:2 Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Energy Metabolism; Enflurane; Halothane; Isoflurane; Liver; Liver Diseases; Male; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred F344	1987
Studies of the toxicity of I-653, halothane, and isoflurane in enzyme-induced, hypoxic rats. Anesthesia and analgesia, 1987, Volume: 66, Issue:12 Topics: Anesthetics; Animals; Desflurane; Enzyme Induction; Halothane; Hypoxia; Isoflurane; Kidney; Liver; Lung; Male; Phenobarbital; Rats	1987
Halothane hepatotoxicity--again? Anesthesia and analgesia, 1986, Volume: 65, Issue:8 Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; Humans; Hypoxia; Microsomes, Liver; Oxygen Consumption; Phenobarbital; Rats; Triiodothyronine	1986
Oxygen concentrations required for reductive defluorination of halothane by rat hepatic microsomes. Anesthesia and analgesia, 1986, Volume: 65, Issue:8 Topics: Animals; Aroclors; Biotransformation; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Fluorine; Halothane; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains	1986
Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. Anesthesiology, 1986, Volume: 65, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Analysis of Variance; Animals; Energy Metabolism; Fasting; Halothane; Hypoxia; In Vitro Techniques; Lactates; Lactic Acid; Liver; Male; Phenobarbital; Rats; Rats, Inbred F344	1986
Ethanol-induced adrenomedullary catecholamine secretion in LS/Ibg and SS/Ibg mice. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:3 Topics: Adrenal Medulla; Animals; Blood Glucose; Body Temperature; Brain; Catecholamines; Chlorisondamine; Dose-Response Relationship, Drug; Ethanol; Halothane; Male; Mice; Phenobarbital; Respiration	1986
Nitrous oxide does not hinder the repair of halothane-induced hepatic injury in the rat. Anesthesia and analgesia, 1985, Volume: 64, Issue:5 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Bretylium Compounds; Chemical and Drug Induced Liver Injury; DNA; Halothane; Isoflurane; Liver Diseases; Liver Regeneration; Male; Nitrous Oxide; Phenobarbital; Rats; Rats, Inbred Strains	1985
Sex differences in halothane metabolism and hepatotoxicity in a rat model. Anesthesia and analgesia, 1985, Volume: 64, Issue:6 Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Biotransformation; Breath Tests; Chemical and Drug Induced Liver Injury; Drug Interactions; Female; Fluorides; Halothane; Hypoxia; Liver Diseases; Male; Oxygen Consumption; Phenobarbital; Rats; Rats, Inbred F344; Sex Factors	1985
Comparison of the requirements for hepatic injury with halothane and enflurane in rats. Anesthesia and analgesia, 1985, Volume: 64, Issue:10 Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Enflurane; Fluorides; Halothane; Hot Temperature; Hypoxia; Liver; Male; Models, Biological; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Trifluoroacetic Acid	1985
Histopathological changes in pregnant rat's liver following repeated halothane exposure. Middle East journal of anaesthesiology, 1985, Volume: 8, Issue:3 Topics: Animals; Female; Fetus; Halothane; Lipids; Liver; Male; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats	1985
Histochemical changes in pregnant rat's liver following repeated halothane exposure. Middle East journal of anaesthesiology, 1985, Volume: 8, Issue:3 Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Female; Halothane; Histocytochemistry; Liver; Male; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Succinate Dehydrogenase	1985
Hepatic amidopyrine N-demethylase activity in the calf. Journal of comparative pathology, 1972, Volume: 82, Issue:3 Topics: Aminopyrine; Animals; Arginase; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Cattle; Centrifugation; Deoxyribonucleases; Female; Halothane; Liver; Naphthalenes; Oxidoreductases; Phenobarbital; Staining and Labeling; Time Factors	1972
Binding of radioactivity from 14 C-labeled halothane in isolated perfused rat livers. Anesthesiology, 1973, Volume: 38, Issue:4 Topics: Animals; Bile; Carbon Dioxide; Carbon Isotopes; Cytosol; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; NADP; Oxygen Consumption; Perfusion; Phenobarbital; Proadifen; Proteins; Rats	1973
The effects of multiple anaesthetics on the livers of rats subjected to microsomal enzyme induction. A preliminary report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, May-12, Volume: 47, Issue:18 Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; Ethyl Ethers; Halothane; Liver; Liver Diseases; Liver Function Tests; Microsomes, Liver; Necrosis; Phenobarbital; Rats; Sulfobromophthalein	1973
The metabolic breakdown of inhalation anaesthetics and their clinical implications. Acta anaesthesiologica Belgica, 1973, Volume: 24, Issue:2 Topics: Anesthesia, Inhalation; Anesthetics; Animals; Disulfiram; Dogs; Ethers; Halothane; Humans; Kidney; Liver; Methoxyflurane; Phenobarbital; Time Factors	1973
Proceedings: Kinetics of the binding of carbon monoxide and oxygen to microsomal cytochrome P450 and the influence of substrates. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 282, Issue:Suppl Topics: Animals; Binding Sites; Carbon Monoxide; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Halothane; Hexobarbital; In Vitro Techniques; Kinetics; Ligands; Metyrapone; Microsomes, Liver; Oxygen Consumption; Phenobarbital; Photolysis; Rats; Spectrophotometry; Temperature; Tetrachloroethylene; Trichloroethylene	1974
The mechanism of halothane binding to microsomal cytochrome P450. Naunyn-Schmiedeberg's archives of pharmacology, 1974, Volume: 285, Issue:4 Topics: Animals; Azo Compounds; Benzopyrenes; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dithionite; Ethylamines; Halothane; Hydrazines; Ligands; Male; Microsomes, Liver; Phenobarbital; Protein Binding; Rats; Spectrophotometry	1974
Spectral analysis as a method of quantitative interpretation of Doppler-shift signals. Cardiovascular research, 1974, Volume: 8, Issue:6 Topics: Angiography; Animals; Benzene Derivatives; Blood Flow Velocity; Cardiac Output; Doppler Effect; Dye Dilution Technique; Halothane; Hexamethonium Compounds; Horses; Methoxyflurane; Phenobarbital; Physical Phenomena; Physics; Pulmonary Artery; Rheology; Sheep; Spectrum Analysis; Transducers; Ultrasonics; Ultrasonography	1974
[The effect of phenobarbital and halogenated hydrocarbons on nitrosamine carcinogenesis]. Zeitschrift fur Krebsforschung, 1969, Volume: 72, Issue:3 Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Drug Synergism; Halothane; Hemangioendothelioma; Hydrocarbons, Halogenated; Kidney; Liver; Liver Neoplasms; Lung; Methoxyflurane; Mice; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Spleen; Stomach	1969
Anesthetic potency compared with intensity of effect on oxygen consumption in monolayer cultures. Proceedings of the Western Pharmacology Society, 1968, Volume: 11 Topics: Amobarbital; Anesthetics; Anesthetics, Local; Animals; Barbiturates; Chloroform; Culture Techniques; Dibucaine; Ethers; Ethyl Ethers; Halothane; Lidocaine; Methohexital; Methoxyflurane; Mice; Oxygen Consumption; Phenobarbital; Prilocaine; Procaine; Secobarbital; Tetracaine; Thiamylal; Thiopental	1968
A comparison of the effects of halothane and CCl 4 on the hepatic drug metabolizing system. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 177, Issue:3 Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochromes; Dealkylation; Halothane; Liver; Male; Microscopy, Electron; Microsomes, Liver; Mixed Function Oxygenases; Morphinans; NADP; Organ Size; Oxidoreductases; Phenobarbital; Rats	1971
Hepatic microsomal lipoperoxidation and inhalation anesthetics: a biochemical and morphologic study in the rat. Anesthesiology, 1972, Volume: 36, Issue:5 Topics: Animals; Chloroform; Ethers; Ethyl Ethers; Female; Halothane; In Vitro Techniques; Lipid Metabolism; Liver; Male; Microsomes, Liver; NADP; Phenobarbital; Rats	1972
Fluroxene toxicity in mice. Anesthesiology, 1972, Volume: 37, Issue:5 Topics: Animals; Biotransformation; Carbon Tetrachloride; Drug Interactions; Enzyme Induction; Ethanol; Ethers; Fluorine; Halothane; Male; Mice; Mice, Inbred Strains; Phenobarbital; Time Factors	1972
Mechanisms of acute hepatic toxicity: chloroform, halothane, and glutathione. Anesthesiology, 1974, Volume: 41, Issue:6 Topics: Acute Disease; Anesthesia, Inhalation; Aniline Compounds; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chloroform; Chromatography, Gas; Cytochrome Reductases; Enzyme Induction; Glutathione; Halothane; Hexobarbital; Liver; Male; Maleates; Microsomes, Liver; Phenobarbital; Rats	1974
A program of general anesthesia for dental care of mentally retarded patients. Oral surgery, oral medicine, and oral pathology, 1974, Volume: 37, Issue:3 Topics: Adolescent; Adult; Anesthesia, General; Child; Dental Care; Evaluation Studies as Topic; Halothane; Hepatitis; Humans; Intellectual Disability; Methods; Middle Aged; Phenobarbital; Postoperative Complications	1974
Biochemical effects of halothane. Acta anaesthesiologica Scandinavica. Supplementum, 1972, Volume: 49 Topics: Adult; Animals; Autoantibodies; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Drug Hypersensitivity; Drug Interactions; Female; Fluorescent Antibody Technique; Halothane; Humans; Liver; Liver Circulation; Lymphocytes; Male; Middle Aged; Phenobarbital; Rats	1972
Autoimmune response in experimental halothan-induced liver injury. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 142, Issue:3 Topics: Animals; Antibody Formation; Autoantibodies; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Halothane; Injections, Intraperitoneal; Liver Diseases; Male; Mitochondria; Phenobarbital; Rats	1973
[Drugs and the liver]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1972, Jun-20, Volume: 61, Issue:25 Topics: Biopsy; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; Humans; Liver; Liver Diseases; Microscopy, Electron; Pharmaceutical Preparations; Pharmacology; Phenobarbital	1972
[Effect of inhalational anesthetics on hepatic microsomal enzymes (oxidative drug metabolizing enzymes)]. Masui. The Japanese journal of anesthesiology, 1972, Volume: 21, Issue:13 Topics: Anesthesia, Inhalation; Anesthetics; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Halothane; Male; Methoxyflurane; Microsomes, Liver; Phenobarbital; Rats	1972
The absence of effect of phenobarbital on halothane toxicity. Research communications in chemical pathology and pharmacology, 1973, Volume: 5, Issue:1 Topics: Aerosols; Animals; Aspartate Aminotransferases; Body Weight; Halothane; Kidney; L-Lactate Dehydrogenase; Liver; Male; Necrosis; Organ Size; Phenobarbital; Rats	1973
Changes of fluoride content in bone: an index of drug defluorination in vivo. Anesthesiology, 1973, Volume: 38, Issue:4 Topics: Anesthetics; Animals; Biotransformation; Body Weight; Bone and Bones; Chlorine; Drug Interactions; Ethanol; Ethers; Female; Fluoridation; Fluorides; Fluorine; Furans; Halothane; Hydrocarbons, Halogenated; Lethal Dose 50; Male; Methoxyflurane; Methyl Ethers; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Pregnancy; Proadifen; Rats; Time Factors	1973
The effect of phenobarbitone anaesthesia upon some organic phosphates, glycolytic metabolites and citric acid cycle-associated intermediates of the rat brain. Journal of neurochemistry, 1973, Volume: 20, Issue:6 Topics: Adenine Nucleotides; Anesthesia, General; Animals; Brain; Carbon Dioxide; Citric Acid Cycle; Depression, Chemical; Glycolysis; Halothane; Hydrogen-Ion Concentration; Hypercapnia; Hyperventilation; Lactates; Male; Nitrous Oxide; Organophosphorus Compounds; Phenobarbital; Phosphocreatine; Pyruvates; Rats; Stimulation, Chemical	1973
Influence of different types of narcosis and of neck fracture on the concentration of glycolytic intermediates and related compounds in rat liver. Archives of biochemistry and biophysics, 1973, Volume: 158, Issue:1 Topics: Adenosine Monophosphate; Adenosine Triphosphate; Anesthetics; Animals; Citrates; Ethyl Ethers; Fractures, Bone; Glycerophosphates; Glycolysis; Halothane; Hexobarbital; Hexosephosphates; Lactates; Liver; Malates; Male; Neck; Oxaloacetates; Pentobarbital; Phenobarbital; Pyruvates; Rats; Time Factors; Urethane	1973
Acute interaction of drugs. I. The effect of volatile anesthetics on the kinetics of aniline hydroxylase and aminopyrine demethylase in rat hepatic microsomes. Biochemical pharmacology, 1973, Sep-01, Volume: 22, Issue:17 Topics: Aminopyrine N-Demethylase; Anesthetics; Aniline Compounds; Animals; Chloroform; Enzyme Induction; Ethyl Ethers; Halothane; In Vitro Techniques; Kinetics; Male; Methoxyflurane; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases, N-Demethylating; Phenobarbital; Rats	1973
Liver injury following halothane anesthesia in phenobarbital-pretreated rats. Biochemical pharmacology, 1974, Jan-15, Volume: 23, Issue:2 Topics: Alkadienes; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Glycine; Halothane; Liver; Male; Microsomes, Liver; Phenobarbital; Protein Biosynthesis; Rats; Sodium Chloride; Time Factors	1974
Effects of methoxyflurane anesthesia on adrenal medullary catecholamine secretion: inhibition of spontaneous secretion and secretion evoked by splanchnic-nerve stimulation. Anesthesiology, 1974, Volume: 41, Issue:1 Topics: Acid-Base Equilibrium; Adrenal Medulla; Anesthesia, Inhalation; Animals; Blood Pressure; Catecholamines; Electric Stimulation; Epinephrine; Halothane; Hemodynamics; Methoxyflurane; Norepinephrine; Oxygen; Phenobarbital; Splanchnic Nerves	1974
[Mixed function oxidation and lipid peroxidation in the liver microsomes--in relationship with metabolism of anesthetics]. Masui. The Japanese journal of anesthesiology, 1974, Volume: 23, Issue:1 Topics: Animals; Halothane; In Vitro Techniques; Lipid Metabolism; Methoxyflurane; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats	1974
[Histological, histochemical and electron microscopical findings in foreign substance induced liver hypertrophy in white mice]. Acta histochemica, 1967, Volume: 26, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Endoplasmic Reticulum; Halothane; Hypertrophy; Liver Diseases; Liver Glycogen; Male; Mice; Microscopy, Electron; Mitochondria, Liver; Phenobarbital; Thiopental	1967
Lidocaine metabolism in normal and phenobarbital-pretreated dogs. Anesthesiology, 1972, Volume: 36, Issue:3 Topics: Acetanilides; Amines; Anesthesia, General; Animals; Biotransformation; Chromatography, Gas; Dogs; Enzyme Induction; Ethylamines; Halothane; Lidocaine; Liver; Phenobarbital; Preanesthetic Medication; Xylenes	1972
The influence of deep barbiturate anesthesia upon the regulation of extra- and intracellular pH in the rat brain during hypercapnia. Acta physiologica Scandinavica, 1972, Volume: 85, Issue:2 Topics: Acid-Base Equilibrium; Anesthesia, General; Animals; Brain; Cerebrospinal Fluid; Halothane; Hydrogen-Ion Concentration; Hypercapnia; Male; Phenobarbital; Rats; Time Factors	1972
Effects of phenobarbital pretreatment on the response of rat liver to halothane administration. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 140, Issue:4 Topics: Anesthesia, General; Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Enzyme Induction; Halothane; Liver; Male; Microsomes, Liver; Necrosis; Paralysis; Phenobarbital; Preanesthetic Medication; Rats; Rats, Inbred Strains; Zoxazolamine	1972
[Gaschromatopraphic, biochemical and ultramicroscopy studies in rats following repeated single- and combined doses of phenobarbital and halothane]. Der Anaesthesist, 1972, Volume: 21, Issue:8 Topics: Anesthesia; Animals; Bicarbonates; Carbon Dioxide; Chromatography, Gas; Drug Synergism; Endoplasmic Reticulum; Halothane; Liver; Male; Microscopy, Electron; Mitochondria; Organ Size; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains	1972
[Hyperthermia during anesthesia]. Nordisk medicin, 1971, Aug-26, Volume: 86, Issue:34 Topics: Anesthesia, General; Body Temperature; Child; Chlorpromazine; Fever; Halothane; Humans; Male; Phenobarbital; Respiration, Artificial; Steroids; Succinylcholine	1971
[Viewpoints on halothanes toxic effects on the liver]. Nordisk medicin, 1970, Nov-05, Volume: 84, Issue:45 Topics: Halothane; Humans; Liver; Phenobarbital	1970
[Studies on the influence of inhalation anesthesia and surgery on liver function with special reference to halothane]. Der Anaesthesist, 1970, Volume: 19, Issue:10 Topics: Anesthesia, Inhalation; Anesthetics; Animals; Chloroform; Enzyme Activation; Enzyme Induction; Halothane; Humans; Liver; Liver Diseases; Liver Function Tests; Phenobarbital; Rats; Sulfobromophthalein; Trichloroethylene	1970
[Studies on the effect of an inhalation anesthesia and surgery on the liver function with special reference to halothane. 2]. Der Anaesthesist, 1970, Volume: 19, Issue:9 Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Aspartate Aminotransferases; Bilirubin; Bromides; Enzyme Induction; Female; Glutamate Dehydrogenase; Halothane; Hexobarbital; L-Lactate Dehydrogenase; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Sleep; Stimulation, Chemical	1970
[Anesthesia in diagnostic stereoelectroencephalography]. Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:1 Topics: Age Factors; Anesthesia, General; Anesthetics; Consciousness; Electroencephalography; Halothane; Humans; Injections, Intramuscular; Methods; Nitrous Oxide; Phenobarbital; Premedication; Time Factors	1971
[Comparative animal experiments on the influence of muscle relaxants and narcotics on intraocular pressure]. Klinische Monatsblatter fur Augenheilkunde, 1971, Volume: 158, Issue:6 Topics: Anesthesia, General; Anesthetics; Animals; Barbiturates; Chloralose; Female; Fentanyl; Gallamine Triethiodide; Halothane; Hexobarbital; Injections, Intravenous; Intraocular Pressure; Male; Narcotics; Nitrous Oxide; Phenobarbital; Propanidid; Rabbits; Succinylcholine; Urethane	1971
Intravenous anaesthesia for the ambulant patient. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1968, Jan-27, Volume: 42, Issue:4 Topics: Adolescent; Adult; Aged; Ambulatory Care; Anesthesia, Conduction; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Barbiturates; Blood Pressure; Female; Guinea Pigs; Halothane; Hexobarbital; Humans; Methohexital; Mice; Middle Aged; Phenobarbital; Secobarbital; Succinylcholine; Thiopental	1968
Effects of halothane anaesthesia and surgery on adrenocortical function in man. Canadian Anaesthetists' Society journal, 1968, Volume: 15, Issue:3 Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenal Glands; Adult; Aged; Atropine; Halothane; Humans; Meperidine; Middle Aged; Phenobarbital; Preanesthetic Medication; Surgical Procedures, Operative	1968
Effect of anaesthetics on mature infections of Schistosoma mansoni in the white mouse. Nature, 1965, May-29, Volume: 206, Issue:987 Topics: Amobarbital; Animals; Barbiturates; Chloroform; Ethyl Ethers; Halothane; Hexobarbital; In Vitro Techniques; Liver Circulation; Mesenteric Arteries; Mesenteric Veins; Mice; Pentobarbital; Phenobarbital; Schistosoma; Schistosomiasis; Secobarbital	1965
Metabolism of volatile anesthetics. 3. Induction of microsomal dechlorinating and ether-cleaving enzymes. The Journal of pharmacology and experimental therapeutics, 1966, Volume: 154, Issue:2 Topics: Animals; Carbon Dioxide; Enzyme Induction; Halothane; In Vitro Techniques; Liver; Methoxyflurane; Methylcholanthrene; Microsomes; Phenobarbital; Rats	1966
In vivo spin-trap study on anaerobic dehalogenation of halothane. Life sciences, 1984, Jul-30, Volume: 35, Issue:5 Topics: Anaerobiosis; Animals; Electron Spin Resonance Spectroscopy; Free Radicals; Halothane; Humans; Kinetics; Liver; Methylcholanthrene; Phenobarbital; Rats; Rats, Inbred Strains	1984
Cardiac arrhythmogenic action of benzo(a)pyrene in the rabbit. Toxicology letters, 1983, Volume: 15, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Benzo(a)pyrene; Benzopyrenes; Epinephrine; Ethylene Chlorohydrin; Halothane; Male; Methylcholanthrene; Phenobarbital; Rabbits; Time Factors; Trichloroacetic Acid; Trichloroethylene	1983
Influence of dithiocarb, (+)-catechin and silybine on halothane hepatotoxicity in the hypoxic rat model. Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:2 Topics: Animals; Benzopyrans; Catechin; Chemical and Drug Induced Liver Injury; Ditiocarb; Flavonoids; Fluorides; Glutathione; Halothane; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains; Silymarin; Thiocarbamates	1983
Effects of halothane, isoflurane, enflurane, thiopental, and fentanyl on blood gas values in rats exposed to hypoxia. Anesthesia and analgesia, 1983, Volume: 62, Issue:2 Topics: Anesthetics; Animals; Carbon Dioxide; Chemical and Drug Induced Liver Injury; Enflurane; Fentanyl; Halothane; Hydrogen-Ion Concentration; Isoflurane; Male; Oxygen; Phenobarbital; Rats; Respiration; Thiopental	1983
Isoflurane does not prevent hepatic injury produced by halothane in rats. Anesthesia and analgesia, 1984, Volume: 63, Issue:10 Topics: Animals; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; Isoflurane; Male; Methyl Ethers; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains; Respiration	1984
The effect of halothane, isoflurane, and blood loss on hepatotoxicity and hepatic oxygen availability in phenobarbital-pretreated hypoxic rats. Anesthesia and analgesia, 1984, Volume: 63, Issue:11 Topics: Animals; Chemical and Drug Induced Liver Injury; Halothane; Hemorrhage; Isoflurane; Liver; Liver Circulation; Male; Methyl Ethers; Oxygen; Phenobarbital; Preanesthetic Medication; Rats; Rats, Inbred Strains; Respiration	1984
Effect of nitrous oxide on halothane-induced hepatotoxicity in hypoxic, enzyme-induced rats. British journal of anaesthesia, 1984, Volume: 56, Issue:5 Topics: Animals; Disease Models, Animal; Drug Synergism; Halothane; Liver; Male; Nitrous Oxide; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains	1984
Factors influencing halothane hepatotoxicity in the rat hypoxic model. Toxicology and applied pharmacology, 1980, Volume: 52, Issue:2 Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Halothane; Male; Microsomes, Liver; Oxygen; Phenobarbital; Rats; Time Factors	1980
Anaerobic dehalogenation of halothane by reconstituted liver microsomal cytochrome P-450 enzyme system. Biochemical and biophysical research communications, 1981, Sep-16, Volume: 102, Issue:1 Topics: Anaerobiosis; Animals; Cytochrome P-450 Enzyme System; Halothane; Kinetics; Microsomes, Liver; NADP; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Rabbits	1981
The effect of halothane anesthesia on platelet aggregation in vivo: decreased deposition on polytetrafluoroethylene arterial grafts in dogs. Surgery, 1983, Volume: 93, Issue:6 Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Blood Vessel Prosthesis; Dogs; Evaluation Studies as Topic; Femoral Artery; Halothane; Phenobarbital; Platelet Aggregation; Polytetrafluoroethylene	1983
Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. Toxicology and applied pharmacology, 1983, Jun-30, Volume: 69, Issue:2 Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Glutathione; Halothane; Hyperthyroidism; Hypoxia; Liver; Male; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred Strains	1983
Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. Anesthesiology, 1983, Volume: 59, Issue:3 Topics: Animals; Chemical and Drug Induced Liver Injury; Fasting; Fluorides; Halothane; Hypoxia; Liver Diseases; Male; Phenobarbital; Rats; Rats, Inbred Strains; Starvation; Triiodothyronine	1983
Hepatic Injury following halothane, enflurane, and isoflurane anesthesia in rats. Anesthesiology, 1982, Volume: 56, Issue:1 Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Enflurane; Enzyme Induction; Halothane; Isoflurane; Male; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains	1982
Reductive metabolism of halothane by human and rabbit cytochrome P-450. Binding of 1-chloro-2,2,2-trifluoroethyl radical to phospholipids. Molecular pharmacology, 1982, Volume: 21, Issue:3 Topics: Animals; Chlorofluorocarbons; Cytochrome P-450 Enzyme System; Fatty Acids; Free Radicals; Halothane; Humans; Hydrocarbons, Halogenated; In Vitro Techniques; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Phospholipids; Rabbits	1982
Suicidal inactivation of microsomal cytochrome P-450 by halothane under hypoxic conditions. Biochemical and biophysical research communications, 1982, Volume: 107, Issue:3 Topics: Aerobiosis; Anaerobiosis; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Halothane; Kinetics; Male; Microsomes, Liver; Oxygen; Partial Pressure; Phenobarbital; Protein Binding; Rats	1982
Unscheduled DNA synthesis in rat liver after gastric administration of halothane. Journal of toxicology and environmental health, 1982, Volume: 10, Issue:2 Topics: Animals; Cell Nucleus; DNA; Halothane; Hydroxyurea; Intubation, Gastrointestinal; Liver; Male; Phenobarbital; Rats; Thymidine	1982
Modification of liver microsomal lipids by halothane metabolites; a multi nuclear NMR spectroscopic study. Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 321, Issue:3 Topics: Animals; Biotransformation; Halothane; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Membrane Lipids; Microsomes, Liver; Phenobarbital; Phosphatidylcholines; Phosphatidylethanolamines; Rabbits	1982
Potentiation of inhibition by general anaesthetics in neurones of the olfactory cortex in vitro. Pflugers Archiv : European journal of physiology, 1980, Volume: 383, Issue:3 Topics: Anesthetics; Animals; Central Nervous System; Chloralose; Guinea Pigs; Halothane; In Vitro Techniques; Ketamine; Membrane Potentials; Methohexital; Neural Conduction; Neurons; Olfactory Pathways; Pentobarbital; Phenobarbital; Urethane	1980
Hepatic blood flow in phenobarbital-pretreated rats during halothane anesthesia and hypoxia. Anesthesia and analgesia, 1981, Volume: 60, Issue:5 Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Cardiac Output; Halothane; Hypoxia; Liver Circulation; Male; Phenobarbital; Rats	1981
Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains. Anesthesiology, 1981, Volume: 55, Issue:2 Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Enzyme Induction; Ethylenes; Genetic Variation; Halothane; Hydrocarbons, Halogenated; Hypoxia; Liver; Male; Phenobarbital; Rats; Rats, Inbred Strains	1981
Role of reactive intermediates in halothane associated liver injury. Advances in experimental medicine and biology, 1981, Volume: 136 Pt A Topics: Animals; Biotransformation; Cytochrome P-450 Enzyme System; Halothane; Kinetics; Liver; Microsomes, Liver; Phenobarbital; Rats	1981
Time-course of formation of volatile reductive metabolites of halothane in humans and an animal model. British journal of anaesthesia, 1980, Volume: 52, Issue:3 Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Disease Models, Animal; Enzyme Induction; Ethylenes; Female; Halothane; Humans; Hydrocarbons, Halogenated; Kinetics; Male; Middle Aged; Phenobarbital; Rats; Rats, Inbred F344	1980
Mechanism of the microsomal reduction of carbon tetrachloride and halothane. Chemico-biological interactions, 1981, Mar-01, Volume: 34, Issue:2 Topics: Animals; Benzopyrenes; Biotransformation; Carbon Tetrachloride; Chloroform; Deuterium; Gas Chromatography-Mass Spectrometry; Halothane; Hydrogen; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats	1981
Nuclear translocation of heat shock protein 72 in liver cells of halothane-exposed rats. Biochemical and biophysical research communications, 1994, Mar-15, Volume: 199, Issue:2 Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Cell Nucleolus; Cell Nucleus; Halothane; Heat-Shock Proteins; Immunohistochemistry; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley	1994
Leukotriene B4 formation upon halothane-induced lipid peroxidation in liver membrane fractions under low O2 concentrations in vitro. European journal of biochemistry, 1994, Jan-15, Volume: 219, Issue:1-2 Topics: Aerobiosis; Anaerobiosis; Animals; Biotransformation; Cell Membrane; Halothane; Leukotriene B4; Lipid Peroxidation; Lipoxygenase Inhibitors; Liver; Male; Models, Biological; NADP; Oxidation-Reduction; Oxygen; Phenobarbital; Rats; Rats, Sprague-Dawley	1994
Interaction of fluoroethane chlorofluorocarbon (CFC) substitutes with microsomal cytochrome P450. Stimulation of P450 activity and chlorodifluoroethene metabolism. Biochemical pharmacology, 1993, Jul-06, Volume: 46, Issue:1 Topics: Animals; Chlorofluorocarbons; Chlorofluorocarbons, Ethane; Cytochrome P-450 Enzyme System; Halothane; Hydrocarbons, Fluorinated; Male; Microsomes, Liver; NADP; Oxygen Consumption; Phenobarbital; Rabbits; Solubility	1993
Demonstration of halothane-induced hepatic lipid peroxidation in rats by quantification of F2-isoprostanes. Anesthesiology, 1996, Volume: 84, Issue:4 Topics: Anesthetics, Inhalation; Animals; Dinoprost; Halothane; Isoniazid; Lipid Peroxidation; Liver; Male; Phenobarbital; Rats; Rats, Sprague-Dawley	1996
Reductive metabolism of halothane by cytochrome P450 isoforms in rats and humans. Research communications in molecular pathology and pharmacology, 1996, Volume: 93, Issue:3 Topics: Anaerobiosis; Anesthetics, Inhalation; Animals; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Halothane; Humans; Isoenzymes; Male; Microsomes, Liver; Oxidation-Reduction; Phenobarbital; Rats; Rats, Sprague-Dawley; Spectrophotometry	1996
THE RADIOGRAPHER AND THE ANAESTHETIST. Radiography, 1964, Volume: 30 Topics: Amobarbital; Anesthesia; Anesthesia, Endotracheal; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics; Anesthetics, Local; Angiography; Cerebral Angiography; Equipment and Supplies; Halothane; Humans; Phenobarbital; Preanesthetic Medication; Radiography; Trichloroethylene	1964