halothane has been researched along with caffeine in 360 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 130 (36.11) | 18.7374 |
| 1990's | 141 (39.17) | 18.2507 |
| 2000's | 56 (15.56) | 29.6817 |
| 2010's | 27 (7.50) | 24.3611 |
| 2020's | 6 (1.67) | 2.80 |
| Authors | Studies |
|---|---|
| Blake, JF; Curatolo, WJ; Lombardo, F | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Durbin, CG; Rosenberg, H | 1 |
| Lampo, P; Muylle, E; Oyaert, W; van Cauteren, H; van den Hende, C | 1 |
| Kalow, W | 1 |
| Britt, BA; Chan, FY; Kalow, W | 1 |
| Britt, BA | 2 |
| Rosenberg, H | 3 |
| Crocker, BD; Denborough, MA; Okumura, F | 2 |
| Britt, BA; Harrison, JE; McNeill, KG | 1 |
| Flewellen, EH; Nelson, TE | 5 |
| Kerrick, WG; Su, JY | 1 |
| Moulds, RF | 1 |
| Austin, KL; Denborough, MA; Nelson, TE | 1 |
| Britt, BA; Endrenyi, L; Kalow, W; Peters, PL | 1 |
| Bedell, DM; Jones, EW; Nelson, TE | 1 |
| Clarke, IM; Ellis, FR | 1 |
| Anderson, IL; Jones, EW | 1 |
| Hofmann, WW | 1 |
| Holland, M; Lee, JC; Williams, JH | 3 |
| Rooke, GA; Su, JY | 1 |
| Bendixen, D; Ording, H | 2 |
| Cosgrove, SB; Eisele, PH; Gronert, GA; Martucci, RW | 1 |
| Ellis, FR; Halsall, PJ; Hopkins, PM | 3 |
| Denborough, MA; Foster, PS; Hopkinson, KC | 2 |
| Couchman, KG; McKenzie, AJ; Pollock, N | 1 |
| Endo, M; Iino, M; Kawana, Y; Oyamada, H | 1 |
| Carrier, L; Dupont, Y; Villaz, M | 1 |
| Beech, J; Fletcher, JE; Rosenberg, H | 1 |
| Adamantidis, MM; Adnet, PJ; Cordonnier, C; Haudecoeur, G; Imbenotte, M; Krivosic-Horber, RM; Reyford, GH | 1 |
| Holland, M; Lee, JC; McGrath, CJ; Ward, CW; Williams, JH | 1 |
| Davy, KP; Holland, M; Lee, JC; Ward, CW; Williams, JH | 1 |
| Bunn, JS; Diaz, M; Landis, JR; Larach, MG | 1 |
| Adamantidis, MM; Adnet, PJ; Dupuis, BA; Haudecoeur, G; Krivosic-Horber, RM; Reyford, HG | 1 |
| Bossaert, LL; Heytens, L; Martin, JJ; Van de Kelft, E | 1 |
| Knight, PR; Sheth, N; Wilde, DW; Williams, BA | 1 |
| Kosay, S; Oyman, S; Tok, D; Ulker, S | 1 |
| Gutta, R; Haney, MF; Knight, PR; Wilde, DW | 1 |
| Katsuoka, M; Ohnishi, ST | 2 |
| Britt, BA; de Leon, S; Derdemezi, J; Duff, CL; Fujii, J; Gillard, EF; Khanna, VK; MacLennan, DH; Otsu, K; Worton, RG | 1 |
| Meinecke, CD; Olthoff, D | 1 |
| Engelhardt, W; Hartung, E; Krauspe, R; Preis, I | 1 |
| Eldar, I; Glauber, V; Goldberg, G; Perel, A | 1 |
| Benders, AA; Joosten, EM; Poels, PJ; Sengers, RC; Stadhouders, AM; Veerkamp, JH | 1 |
| Denborough, MA; Foster, PS; Hopkinson, KC; Payne, N | 1 |
| Gallagher, WJ; Iaizzo, PA; Wedel, DJ | 1 |
| Britt, B; Kalow, W; Sharer, S | 1 |
| Roewer, N; Rum, U; Schmitz, W; Scholz, H; Scholz, J; Schulte am Esch, J | 1 |
| Eichinger, HM; Iaizzo, PA; Lehmann-Horn, F; Seewald, MJ | 1 |
| Cardinet, GH; Elliott, TE; Gronert, GA; Jaffe, RS; Martucci, RW | 1 |
| Bonsett, C; Dierdorf, SF; Krishna, G; Patel, VK | 1 |
| Britt, BA; Duff, C; Frodis, W; Fujii, J; Korneluk, RG; MacLennan, DH; Phillips, M; Worton, RG; Zorzato, F | 1 |
| Allen, G; Chance, B; Olgin, J; Rosenberg, H; Seestedt, R | 1 |
| Bonk, KR; Brooks, RR; Carpenter, JF; Miller, KE | 1 |
| Nelson, TE | 3 |
| Censier, K; Drewe, J; Frei, F; Rothenbühler, JM; Seeberger, MD; Urwyler, A | 1 |
| Peracchia, C | 2 |
| Fletcher, JE; Levitt, RC; Meyers, D; Rosenberg, H | 1 |
| Allen, G; Crossan, ML; Korneluk, R; Lahey, D; MacKenzie, AE; MacLennan, DH; Mettler, G; Nolan, K; Worton, RG | 1 |
| Britt, BA; Elliott, ME; Klip, A; Mills, GB | 1 |
| Adamantidis, M; Adnet, P; Dupuis, B; Krivosic-Horber, R; Leys, D; Reyford, H | 1 |
| O'Brien, PJ | 1 |
| Mortier, W | 1 |
| Fletcher, JE; Huggins, FJ; Rosenberg, H | 1 |
| Stratton, M | 1 |
| Suarez-Kurtz, G; Sudo, RT; Zapata-Sudo, G | 1 |
| Iaizzo, PA; Lehmann-Horn, F | 2 |
| Allen, GC; Conner, GE; Fletcher, JE; Huggins, FJ; Rosenberg, H | 1 |
| Allen, GC; Conti, PA; Fletcher, JE; Huggins, FJ; Rosenberg, H | 1 |
| Deufel, T; Farrall, M; Healy, JM; Heffron, JJ; Johnson, K; Lehane, M; Lehmann-Horn, F; McCarthy, TV | 1 |
| Adamantidis, MM; Adnet, PJ; Dupuis, BA; Haudecoeur, G; Krivosic-Horber, RM; Reyfort, GH | 1 |
| Allen, GC; Fletcher, JE; Rosenberg, H | 1 |
| Dubrow, TJ; Dudley, JP; Reynolds, R | 1 |
| Arpin, D; Cardinet, G; Hildebrand, SV | 1 |
| Gericke, GS; Isaacs, H | 1 |
| Ording, H | 3 |
| Ali, N; Kalow, BI; Lassaline, LA; Lumsden, JH; O'Brien, PJ | 1 |
| Suarez-Kurtz, G; Sudo, RT; Trachez, MM | 1 |
| Fang, SR; Flick, JL; Horiuchi, K; Ohnishi, ST; Ohnishi, T; Sadanaga, KK; Waring, AJ | 1 |
| Ohnishi, ST | 1 |
| Palade, P | 1 |
| Krivosic, I; Krivosic-Horber, R | 1 |
| Fletcher, JE; Gong, QH; Rosenberg, H; Wieland, SJ | 1 |
| Adnet, P; Krivosic-Horber, R | 1 |
| Adamantidis, MM; Adnet, PJ; Adnet-Bonte, CA; Dupuis, BA; Haudecoeur, G; Krivosic-Horber, RM; Saulnier, F | 1 |
| Hackl, W; Mauritz, W; Steinbereithner, K; Winkler, M | 1 |
| Larach, MG | 1 |
| Iaizzo, PA; Lehmann-Horn, F; Oakes, SG; Seewald, M | 1 |
| Kumeta, H; Namiki, A; Narimatsu, E; Sumita, S; Tateishi, M; Watanabe, H | 1 |
| Denborough, MA; Foster, PS; Hopkinson, K | 1 |
| Fletcher, JE; Lizzo, FH; Rosenberg, H | 1 |
| Katsuoka, M; Kobayashi, K; Ohnishi, ST | 1 |
| Denborough, MA; Foster, PS | 2 |
| Krane, EJ; Su, JY | 1 |
| Su, JY; Zhang, CC | 1 |
| Gronert, GA; Kien, ND; Martucci, RW; Melton, AT | 1 |
| Burket, RC; Hodgin, JD | 1 |
| Gallant, EM; Jacobson, BA; Johnson, KM; Litterer, LA; Louis, CF; Mickelson, JR; Rempel, WE | 1 |
| Britt, BA; Elliott, ME; Frodis, W; Klip, A; Pegg, W; Scott, E | 1 |
| Endo, M; Morohoshi, Y; Nakano, T; Ohga, A; Ohta, T; Wanikawa, K | 1 |
| Gage, PW; Robertson, B | 1 |
| Gascard, JP; Kozak-Reiss, G; Laxenaire, MC; Moeller, R | 1 |
| Abdul-Rasool, IH; Dubrow, TJ; Lesavoy, MA; Wackym, PA | 1 |
| Hansford, RG; Lakatta, EG; Rice, RT; Wheeler, DM | 1 |
| Pagala, MK; Sahgal, V; Shah, AJ; Subramani, V; Venkatachari, SA | 1 |
| Collins, SP; Denborough, MA; White, MD | 1 |
| Hansen, U; Ording, H; Skovgaard, LT | 1 |
| Adamantidis, M; Adnet, P; Guévart, E; Krivosic, I; Krivosic-Horber, R; Theunynck, D | 1 |
| Fletcher, JE; Heiman-Patterson, TD; Rosenberg, H; Tahmoush, AJ | 1 |
| Iaizzo, PA; Klein, W; Lehmann-Horn, F | 1 |
| Graf, M; Hackl, W; Mauritz, W; Sluga, E; Sporn, P; Steinbereithner, K | 1 |
| Adnet, P; Guevart, E; Krivosic-Horber, R; Lestavel, P; Theunynck, D | 1 |
| Broennle, AM; Larach, DR; Larach, MG; Rosenberg, H | 1 |
| Henriksson, KG; Lennmarken, C; Rutberg, H | 1 |
| Fishbein, WN; Muldoon, SM; Nagarajan, K; Pezeshkpour, G | 1 |
| Ording, H; Skovgaard, LT | 2 |
| Fukumitsu, K; Hayashi, Y; Sumikawa, K; Yoshiya, I | 1 |
| Souza, MR; Suarez-Kurtz, G; Sudo, RT; Zapata, G | 1 |
| Blomquist, S; Fletcher, R; Ranklev, E | 1 |
| Amaha, K; Fudeta, H; Iwatsuki, N; Shiozawa, S; Shiratori, T | 1 |
| Anwyl, R; Bruton, JD; McLoughlin, JV | 1 |
| Fletcher, R; Ranklev, E | 1 |
| Gascard, JP; Kozak-Reiss, G; Redouane-Bénichou, K | 1 |
| Biscardi, HM; Condon, BF; Muldoon, SM | 1 |
| Fletcher, JE; Rosenberg, H | 2 |
| Britt, BA; Scott, EA | 1 |
| Suarez-Kurtz, G; Sudo, RT | 1 |
| Fletcher, TF; Gallant, EM; Goettl, VM; Rempel, WE | 1 |
| Biscardi, H; Bockman, EL; Deuster, PA; Muldoon, SM | 1 |
| Bell, JG; Su, JY | 1 |
| Brownell, AK; Littmann, V; Paasuke, RT; Walsh, MP | 1 |
| Bockman, EL; Deuster, PA; Muldoon, SM | 1 |
| Fishbein, WN | 1 |
| Fletcher, R; Krantz, P; Ranklev, E | 1 |
| Fletcher, R; Monti, M; Ranklev, E | 1 |
| Dozier, SE; Fulfer, RT; Ilias, WK; Williams, CH | 1 |
| Armbrustmacher, VW; Deuster, PA; Fishbein, WN; Muldoon, SM | 1 |
| Britt, BA; Haist, C; Kalow, W; Terreau, ME | 1 |
| Hall, GM; Lister, D | 1 |
| Vesell, ES | 1 |
| Denborough, MA; Moulds, RF | 3 |
| Ellis, FR; Harriman, DG; Keaney, NP | 1 |
| Bull, AB; Harrison, GG | 1 |
| Bianchi, CP; Strobel, GE | 1 |
| Tollefson, G | 1 |
| Caroff, S; Gerber, JC; Rosenberg, H | 1 |
| Fletcher, JE; Hilf, M; Rosenberg, H | 1 |
| Dhalla, NS; Ganguly, PK; Lamers, JM; Sulakhe, PV | 1 |
| Arnett, DW; Flewellen, EH; Nelson, TE | 1 |
| Fletcher, R; Ording, H; Ranklev, E | 1 |
| Becker, MJ; Eng, GD; Muldoon, SM | 1 |
| Kruse, H; Rössner, M; Siegemund, G | 1 |
| Reed, S; Rosenberg, H | 1 |
| Giger, U; Kaplan, RF | 1 |
| Flewellen, EH; Gloyna, DF; Nelson, TE | 1 |
| Ellis, FR; Halsall, PJ | 1 |
| Anderson, IL; Dunlop, DJ; Rawstron, RE | 1 |
| Sporn, P | 1 |
| Gallant, EM; Godt, RE; Gronert, GA | 1 |
| Brownell, AK; Szabo, M | 1 |
| Biesel, C; Mortier, W | 1 |
| Britt, BA; Clements, MJ; Endrenyi, L; Frodis, W; Scott, E | 1 |
| Kurebayashi, N; Ogawa, Y | 1 |
| Gronert, GA; Onofrio, BM; Thompson, RL | 1 |
| Su, JY | 1 |
| Chausmer, AB; Nelson, TE | 1 |
| Denborough, MA; Sullivan, JS | 1 |
| Britt, BA; Endrenyi, L; Frodis, W; Scott, E | 1 |
| Gronert, GA | 1 |
| Britt, BA; Huckell, VF; Mambo, NC; McEwan, PM; McLaughlin, PR; Morch, JE; Silver, MD | 1 |
| Coleman, AW; Coleman, JR | 1 |
| Hori, M; Kamada, T; Kimura, Y; Kuzuya, T; Nishida, K; Otsu, K; Tada, M | 1 |
| Lynch, C; Pancrazio, JJ | 1 |
| Fletcher, JE; Hubert, M; Levitt, RC; Rosenberg, H; Tripolitis, L; Vita, GM | 1 |
| Hofer, BO; Sivarajan, M; Su, JY | 1 |
| Becker, K; Köchling, A; Lenzen, C; Roewer, N; Scholz, J; Schulte am Esch, J; Singh, S; Steinfath, M; Wappler, F | 1 |
| Beech, J; Dawso, T; Fletcher, JE; Lindborg, S; Tripolitis, L | 1 |
| Fujita, S; Namba, H; Namiki, A; Notsuki, E; Tsuchida, H; Yamakage, M | 1 |
| Greim, C; Roewer, N; Rumberger, E; Schulte am Esch, J | 1 |
| Brum, JM; DeBoer, GE; Mitsumoto, H; Sato, N | 1 |
| Adnet, P; Adnet-Bonte, C; Bello, N; Etchrivi, T; Krivosic-Horber, R; Lestavel, P; Reyford, H; Saulnier, F; Tavernier, B | 1 |
| Britt, BA; Carr, AS; Cunliffe, M; Lerman, J; McLeod, ME | 1 |
| Boyle, WA; Maher, GM | 1 |
| Adnet, P; Ducart, A; Krivosic-Horber, R; Renaud, B; Riou, B | 1 |
| Dickinson, PJ; Sullivan, M | 1 |
| Davidson, BA; Knight, PR; Smith, MD | 1 |
| Anetseder, M; Hartung, E; Klepper, S; Reichmann, H | 1 |
| Fletcher, JE; O'Flynn, RP; Rosenberg, H; Shutack, JG | 1 |
| Censier, K; Drewe, J; Kaufmann, MA; Urwyler, A | 1 |
| Hatano, Y; Kakuyama, M; Mori, K; Nakamura, K; Nishiwada, M; Terasako, K; Toda, H | 1 |
| Adamantidis, MM; Adnet, PJ; Haudecoeur, G; Krivosic, I; Krivosic-Horber, RM; Medahoui, H; Reyford, HG | 1 |
| Nelson, TE; Wedel, DJ | 1 |
| Breucking, E; Mortier, W | 1 |
| Kaus, SJ; Rockoff, MA | 1 |
| Lenzen, C; Roewer, N; Rumberger, R; Scholz, J; Schulte am Esch, J; Steinfath, M; Wappler, F | 1 |
| Badenhorst, M; Isaacs, H | 1 |
| Beech, J; Braund, K; Fletcher, JE; Lindborg, S; Lizzo, F; Tripolitis, L | 1 |
| Benabid, AL; Bosson, JL; Bourdon, L; Jacquot, C; Le Bas, JF; Payen, JF; Stieglitz, P | 1 |
| Bourdon, L; Canini, F | 1 |
| Blackwell, KE; Wackym, PA | 1 |
| Bose, D; Greenberg, CR; MacLennan, DH; Patel, L; Phillips, MS; Serfas, KD; Wrogemann, K | 1 |
| Antognini, JF; Chun, K; Gronert, GA; Hwang, F | 1 |
| Fehr, DM; Larach, DR; Schuler, HG; Zangari, KA | 1 |
| Akata, T; Boyle, W | 1 |
| Camu, F; Christiaens, F; D'Haese, J; Gepts, E | 1 |
| Anetseder, M; Engelhardt, W; Hartung, E; Hogrefe, G; Koob, M; Krauspe, R; Schoemig, P | 1 |
| Braune, H; Köchling, A; Reissinger, T; Roewer, N; Schulte am Esch, J; Wappler, F | 1 |
| Sessler, DI | 1 |
| Herland, J; Julian, FJ; Stephenson, DG | 1 |
| Badenhorst, M; Brooksbank, R; Isaacs, H; Savage, N | 1 |
| duBell, WH; Rice, RT; Spurgeon, HA; Wheeler, DM | 1 |
| Bendahan, D; Confort-Gouny, S; Cozzone, PJ; Kozak-Ribbens, G | 1 |
| Lamb, GD; Owen, VJ; Taske, NL | 1 |
| Ellis, FR; Halsall, PJ; Hopkins, PM; Stewart, AD | 1 |
| Hatano, Y; Kakuyama, M; Maeda, H; Mori, K; Nakamura, K; Tachibana, T; Yamamoto, M | 1 |
| Engel, AG; Wedel, DJ; Weglinski, MR | 1 |
| Berg, K; Fagerlund, TH; Islander, G; Ranklev-Twetman, E | 1 |
| Antognini, JF; Gronert, GA | 1 |
| Bittner, RE; Fricker, R; Gilly, H; Kress, HG; Musat, I; Steinbereithner, K | 1 |
| Bachand, M; Boisvert, M; Chartrand, D; Mayer, FM; Vachon, N | 1 |
| Berg, K; Fagerlund, TH; Islander, G; Ranklev Twetman, E | 1 |
| Adnet, PJ; Ben-Abraham, R; Haudcoeur, G; Krivosic-Horber, RM; Perel, A | 1 |
| Bittner, RE; Gilly, H; Mader, N | 1 |
| Brancadoro, V; Cozzolino, S; Ellis, FR; Glauber, V; Gonano, EF; Halsall, PJ; Hartung, E; Heffron, JJ; Heytens, L; Kozak-Ribbens, G; Kress, H; Krivosic-Horber, R; Lehmann-Horn, F; Mortier, W; Nivoche, Y; Ording, H; Ranklev-Twetman, E; Sigurdsson, S; Snoeck, M; Stieglitz, P; Tegazzin, V; Urwyler, A; Wappler, F | 1 |
| Bendixen, D; Fagerlund, T; Gardi, T; Glahn, K; Ording, H | 1 |
| Demaurex, N; Grinstein, S; MacLennan, DH; McCarthy, TV; Oyamada, H; Tong, J | 1 |
| Dulhunty, AF; Junankar, PR; Lamb, GD; Laver, DR; Owen, VJ; Taske, NL | 1 |
| Ben Abraham, R; Glauber, V; Perel, A; Zweig, A | 1 |
| Kern, C; Moser, N; Roesslein, R; Sutter, PM; Ummenhofer, W; Urwyler, A | 1 |
| Collins, SP; Mendes, LS | 1 |
| Bendixen, D; Berg, K; Fagerlund, TH; Islander, G; Ording, H; Ranklev Twetman, E | 1 |
| Allen, GC; Kunselman, AR; Larach, MG | 1 |
| Adnet, P; Ben Abraham, R; Glauber, V; Perel, A | 1 |
| Ashida, K; Azukari, K; Kasamatsu, Y; Ohsawa, A; Osada, M; Yoshioka, K | 1 |
| Su, JY; Tang, LJ | 1 |
| Köchling, A; Schulte am Esch, JS; Wappler, F; Winkler, G | 1 |
| Barone, V; Bracco, A; Cozzolino, S; Di Martino, A; Intravaia, E; Massa, O; Sorrentino, V; Tegazzin, V | 1 |
| Giblin, L; Heffron, JJ; Lehane, M; Lynch, PJ; MacLennan, DH; Mallet, A; McCarthy, TV; Tong, J; Vaughan, P; Zafra, G | 1 |
| Montes, A; Puig, MM; Ramos, R; Silva, T; Trillo, L | 1 |
| Adnet, PJ; Fletcher, JE; Reyford, H; Rosenberg, H; Stewart, SL; Wieland, SJ | 1 |
| Islander, G; Twetman, ER | 1 |
| Adnet, PJ; Diallo, A; Etchrivi, TS; Haudecoeur, G; Krivosic-Horber, RM; Tavernier, B | 1 |
| Balog, EM; Gallant, EM; Lentz, LR; Mickelson, JR; Valberg, SJ | 1 |
| Antognini, JF; Gronert, GA; Melton, AT | 1 |
| Fiege, M; Richter, A; Scholz, J; Schulte am Esch, J; Steinfath, M; Wappler, F; Weisshorn, R | 1 |
| Adnet, P; Krivosic-Horber, R; Reyford, H; Tavernier, B | 1 |
| Dériaz, O; Frascarolo, P; Freymond, D; Jéquier, E; Reiz, S; Urwyler, A | 1 |
| Bendixen, D; Islander, G; Ording, H; Ranklev-Twetman, E | 1 |
| am Esch, JS; Krause, T; Martens, U; Scholz, J; Steinrücke, K; Wappler, F | 1 |
| Bahia, VS; Marchiori, PE; Oliveira, RA; Scaff, M; Silva, HC; Tsanaclis, AM | 1 |
| Fardeau, M; Lerale, J; Lunardi, J; MacLennan, DH; Monnier, N; Nivoche, Y; Qi, D; Romero, NB | 1 |
| Baur, CP; Froeba, G; Georgieff, M; Jurkat-Rott, K; Klingler, W; Lehmann-Horn, F; Marx, T; Schoch, E | 1 |
| Deutrich, C; Froster, UG; Olthoff, D; Rueffert, H; Thamm, B | 1 |
| Aubert, M; Bendahan, D; Confort-Gouny, S; Cozzone, PJ; Figarella-Branger, D; Ghattas, B; Kozak-Ribbens, G | 1 |
| Bina, S; Karan, SM; Lojeski, EW; Mongan, PD; Muldoon, SM | 1 |
| Hurtevent, JF; Krivosic-Horber, R; Maurage, CA; Moerman, A; Pellissier, JF; Stojkovic, T; Vermersch, P | 1 |
| Deutrich, C; Froster, UG; Olthoff, D; Rueffert, H | 1 |
| Censier, K; Girard, T; Mueller, CR; Treves, S; Urwyler, A; Zorzato, F | 1 |
| Antognini, JF; Muldoon, S; Rosenberg, H | 1 |
| Deutrich, C; Froster, UG; Meinecke, CD; Olthoff, D; Rueffert, H | 1 |
| Brooks, C; Brown, SL; Ellis, FR; Halsall, PJ; Hopkins, PM; Quinnell, RJ; Robinson, RL; Shaw, MA | 1 |
| Fiege, M; Schulte Am Esch, J; Steinfath, M; Ulrich Gerbershagen, M; Wappler, F; Weisshorn, R | 1 |
| Bendixen, D; Islander, G; Ording, H; Ranklev Twetman, E | 1 |
| Allen, PD; López, JR | 1 |
| Bina, S; Brandom, BW; Daly, JW; Gallagher, KL; Holman, SJ; Hosoi, E; Muldoon, S; Pudimat, PA; Sei, Y; Venzon, DJ; Wyre, HW | 1 |
| Asai, T; Ikeda, H; Kusudo, K; Murase, K; Takenoshita, M | 1 |
| Bina, S; Holman, S; Muldoon, SM | 1 |
| Du, G; Kraev, A; Kraev, N; Loke, JC; MacLennan, DH; Patel, L; Sharma, P | 1 |
| Anetseder, M; Baur, CP; Censier, K; Doetsch, S; Felleiter, P; Fiege, M; Fricker, R; Halsall, PJ; Hartung, E; Heffron, JJ; Heytens, L; Hopkins, PM; Klingler, W; Lehmann-Horn, F; Nivoche, Y; Schulte am Esch, J; Tegazzin, V; Tzanova, I; Urwyler, A; Wappler, F; Weisshorn, R | 1 |
| Duke, AM; Hopkins, PM; Steele, DS | 1 |
| Koenig, F; Olthoff, D; Rueffert, H; Wehner, M | 2 |
| Deutrich, C; Froster, UG; Olthoff, D; Rueffert, H; Schober, R | 1 |
| Muldoon, SM; Nelson, TE; Rosenberg, H | 1 |
| Censier, K; Ginz, HF; Girard, T; Urwyler, A | 1 |
| Gillmeister, I; Hommann, M; Schummer, C; Schummer, W | 1 |
| Bendahan, D; Cozzone, PJ; Ghattas, B; Guis, S; Kozak-Ribbens, G; Lunardi, J; Mattei, JP; Monnier, N | 1 |
| Duke, AM; Halsal, JP; Hopkins, PM; Steele, DS | 1 |
| Litman, RS; Rosenberg, H | 1 |
| De La Corte, FD; Dranchak, PK; Ekenstedt, K; Gallant, EM; MacLeay, JM; McKenzie, EC; Mickelson, JR; Onan, GW; Valberg, SJ | 1 |
| Bina, S; Bünger, R; Cowan, G; Karaian, J; Mongan, P; Muldoon, S | 1 |
| Anetseder, M; Hager, M; Müller, R; Roewer, N; Schöll, H; Schuster, F | 1 |
| Gerbershagen, MU; Wappler, F | 1 |
| Duke, AM; Steele, DS | 1 |
| Anetseder, M; Müller, R; Roewer, N; Schuster, F; Tas, P | 1 |
| Guo, XY; Huang, YG; Luo, AL; Ren, HZ; Wang, YL; Xu, ZH; Ye, TH; Zhang, X | 1 |
| Bodelsson, M; Islander, G; Ranklev, E; Rydenfelt, K | 1 |
| Bina, S; Bünger, R; Muldoon, S | 1 |
| Bross, T; Steinmann, D | 1 |
| Ortiz Gómez, JR | 1 |
| Guo, XY; Huang, YG; Luo, AL; Wang, YL; Xu, ZH | 1 |
| Anetseder, M; Hager, M; Metterlein, T; Muellenbach, RM; Roewer, N; Schuster, F; Wunder, C; Wurmb, T | 1 |
| Anetseder, M; Kranke, P; Metterlein, T; Muellenbach, RM; Negele, S; Roewer, N; Schuster, F; Schwemmer, U | 1 |
| Kaufmann, A; Kraft, B; Michalek-Sauberer, A; Weigl, LG | 1 |
| Parness, J | 1 |
| Canato, M; Dainese, M; Dirksen, RT; Lyfenko, AD; Paolini, C; Protasi, F; Quarta, M; Reggiani, C | 1 |
| Booms, P; Carpenter, D; Casson, F; Halsall, PJ; Hogg, M; Hopkins, PM; Iles, DE; Quinnell, RJ; Ringrose, C; Robinson, RL; Shaw, MA; Steele, DS | 1 |
| Finsterer, J; Höftberger, R; Michalek-Sauberer, A | 1 |
| Anetseder, M; Kranke, P; Metterlein, T; Roewer, N; Schuster, F | 1 |
| Carpenter, D; Halsall, PJ; Hopkins, PM; Leo, V; Morris, A; Ringrose, C; Robinson, RL; Shaw, MA | 1 |
| Amoedo, ND; Cunha, LB; Matos, AR; Rumjanek, FD; Sambuughin, N; Sudo, RT; Zapata-Sudo, G | 1 |
| Hirayama, H; Iwami, M; Kuramoto, H; Masuda, K; Shiina, T; Shima, T; Shimizu, Y; Takewaki, T | 1 |
| Abreu, AV; Aguiar, MI; Cardoso, LA; Carmo, PL; Cunha, LB; Matos, AR; Sudo, RT; Trachez, MM; Zapata-Sudo, G | 1 |
| Cui, XL; Guo, XY; Luo, AL; Tan, G; Wang, YL | 1 |
| Hamada, H; Kawamoto, M; Kobayashi, M; Migita, T; Mukaida, K; Yuge, O | 1 |
| Anetseder, M; Hartung, E; Metterlein, T; Roewer, N; Schuster, F | 1 |
| Kaufmann, A; Kraft, B; Kress, HG; Michalek-Sauberer, A; Steinboeck, F; Weigl, LG; Weindlmayr, M | 1 |
| Fusi, F; Höller, C; Kraft, B; Kress, HG; Lacava, C; Michalek-Sauberer, A; Sgaragli, G; Sipos, E; Weigl, LG | 1 |
| Hawryluck, LA; Kraeva, N; Riazi, S; Russell, T; Steel, AC | 1 |
| Islander, G; Melberg, A; Rücker, F; Smits, A; Sundblom, J | 1 |
| Adolph, O; Chaiklieng, S; Hoppe, K; Jurkat-Rott, K; Klingler, W; Lehmann-Horn, F | 1 |
| Hu, C; Kraeva, N; Larach, MG; Massey, C; Riazi, S; Wijeysundera, D | 1 |
| Croul, S; Keith, J; Kraeva, N; Orlov, D; Riazi, S; Rosen, D | 1 |
| Stowell, KM | 1 |
| Hoppe, K; Jäger, H; Klingler, W; Lehmann-Horn, F; Schleip, R | 1 |
| Kraeva, N; Larach, MG; Riazi, S; Rosenberg, H; Sterling, C; Timmins, MA | 1 |
| Abriat, A; Bendahan, D; Brégigeon, M; Brosset, C; Canini, F; Duron-Martinaud, S; Figarella-Branger, D; Jouvion, A; Montigon, C; Sagui, E; Zagnoli, F | 1 |
| Andria, B; Attanasio, C; Bucci, M; Calderone, V; Cantalupo, A; Cirino, G; Di Martino, A; Ianaro, A; Mancini, A; Panza, E; Savoia, G; Vellecco, V | 1 |
| Johannsen, S; Mögele, S; Müller, CR; Roewer, N; Schneiderbanger, D; Schuster, F; Treves, S | 1 |
| Alsina, E; Del Blanco, B; Domínguez, A; García, A; Guerrero, JL; Kollmann-Camaiora, A; Yepes, MJ | 1 |
| Cifra, B; Kraeva, N; Noseworthy, MD; Rayner, TE; Riazi, S; Schneiderman, JE; Thompson, SJ; Wells, GD | 1 |
| Johannsen, S; Roewer, N; Schick, M; Schuster, F | 1 |
| Isbary, S; Johannsen, S; Roewer, N; Schuster, F; Türkmeneli, I | 1 |
| Allen, PD; Diggle, CP; Hopkins, PM; Kaura, V; Lopez, JR | 1 |
| Figueroa, L; Kraeva, N; Manno, C; Riazi, S; Ríos, E; Toro, S | 1 |
| Allen, PD; Dirksen, RT; Lopez, JR | 1 |
| Biesecker, L; Figueroa, L; Hopkins, PM; Ibarra Moreno, CA; Kraeva, N; Riazi, S; Rios, E; Van Petegem, F; Zvaritch, E | 1 |
| Bin, X; Tang, Z; Wang, B | 1 |
| Carlson, KJ; Derkay, CS; Koenig, M; Sun, SA; Swan, C | 1 |
| Figueroa, L; Ibarra-Moreno, CA; Kraeva, N; Manno, C; Riazi, S; Rios, E; Tammineni, ER | 1 |
| Hopkins, PM | 1 |
14 review(s) available for halothane and caffeine
| Article | Year |
|---|---|
Epidemiology and inheritance of malignant hyperthermia.
Topics: Adenosine Triphosphate; Caffeine; Creatine Kinase; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Pedigree | 1979 |
Preanesthetic diagnosis of malignant hyperthermia.
Topics: Adenosine Triphosphate; Caffeine; Cardiac Catheterization; Creatine Kinase; Halothane; Heart; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Radionuclide Imaging; Time Factors | 1979 |
Malignant hyperthermia: relation to other diseases.
Topics: Caffeine; Calcium Channels; Diagnosis, Differential; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Neuroleptic Malignant Syndrome; Neuromuscular Diseases | 1990 |
[Screening tests for malignant hyperthermia susceptibility].
Topics: Animals; Caffeine; Calcium; Cholinesterases; Contracture; Creatine Kinase; Cyclic AMP; Disease Susceptibility; Electrophysiology; Erythrocytes; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscles; Platelet Aggregation; Succinylcholine | 1989 |
Standardization of the caffeine halothane muscle contracture test. North American Malignant Hyperthermia Group.
Topics: Biopsy; Caffeine; Clinical Laboratory Techniques; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; North America; Societies, Medical | 1989 |
Diagnosis of susceptibility to malignant hyperthermia in man.
Topics: Caffeine; Chemistry, Clinical; Disease Susceptibility; Halothane; Hematologic Tests; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles | 1988 |
Polygenic factors controlling drug response.
Topics: Adult; Animals; Antipyrine; Caffeine; Dicumarol; Environment; Ethanol; Female; Genetic Variation; Half-Life; Halothane; Humans; Isoniazid; Male; Metabolic Clearance Rate; Mice; Middle Aged; Nortriptyline; Pharmaceutical Preparations; Phenylbutazone; Pregnancy; Smoking; Twins | 1974 |
Malignant hyperthermia.
Topics: Adolescent; Adult; Anesthesia; Biopsy; Caffeine; Child; Child, Preschool; Clinical Protocols; Counseling; Halothane; Humans; Male; Malignant Hyperthermia; Patient Education as Topic; Risk Factors | 1994 |
Malignant hyperthermia.
Topics: Anesthesia; Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Dantrolene; Halothane; Humans; Malignant Hyperthermia; Muscle Relaxants, Central | 1998 |
Defective Mg2+ regulation of RyR1 as a causal factor in malignant hyperthermia.
Topics: Caffeine; Calcium; Cytosol; Halothane; Humans; Magnesium; Malignant Hyperthermia; Muscle, Skeletal; Ryanodine Receptor Calcium Release Channel | 2007 |
[Anesthesia in malignant hyperthermia].
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Calcium Signaling; Child; Child, Preschool; Diagnosis, Differential; Genetic Heterogeneity; Genetic Predisposition to Disease; Halothane; Humans; Incidence; Infant; Information Centers; Malignant Hyperthermia; Middle Aged; Monitoring, Intraoperative; Muscle Contraction; Neuromuscular Depolarizing Agents; Preoperative Care; Ryanodine Receptor Calcium Release Channel; Spain | 2008 |
DNA testing for malignant hyperthermia: the reality and the dream.
Topics: Biopsy; Caffeine; Calcium Channels; Calcium Channels, L-Type; Computational Biology; Genetic Predisposition to Disease; Genetic Variation; Halothane; Humans; Malignant Hyperthermia; Muscle, Skeletal; Point Mutation; Polymerase Chain Reaction; Ryanodine Receptor Calcium Release Channel; Sequence Analysis, DNA | 2014 |
Clinical protocol for the management of malignant hyperthermia.
Topics: Adolescent; Adult; Caffeine; Calcium Signaling; Child; Child, Preschool; Clinical Protocols; Critical Care; Dantrolene; Diagnosis, Differential; Disease Management; Female; Halothane; Humans; Infant; Infant, Newborn; Male; Malignant Hyperthermia; Muscle Contraction; Muscle Fibers, Skeletal; Neuroleptic Malignant Syndrome; Ryanodine Receptor Calcium Release Channel; Serotonin Syndrome | 2017 |
Anesthetics and Cell-Cell Communication: Potential Ca
Topics: Anesthetics; Anesthetics, Inhalation; Caffeine; Calcium; Calmodulin; Cell Communication; Connexins; Gap Junctions; Halothane; Heptanol; Ion Channels; Isoflurane; Theophylline | 2022 |
5 trial(s) available for halothane and caffeine
| Article | Year |
|---|---|
Prediction of malignant hyperthermia susceptibility in low-risk subjects. An epidemiologic investigation of caffeine halothane contracture responses. The North American Malignant Hyperthermia Registry.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Child; Contracture; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Prognosis; Prospective Studies; Registries; Sensitivity and Specificity | 1992 |
A blinded comparison of noninvasive, in vivo phosphorus nuclear magnetic resonance spectroscopy and the in vitro halothane/caffeine contracture test in the evaluation of malignant hyperthermia susceptibility.
Topics: Adolescent; Adult; Caffeine; Child; Child, Preschool; Disease Susceptibility; Female; Halothane; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Single-Blind Method | 1991 |
Identification of susceptibility to malignant hyperpyrexia.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Creatine Kinase; Drug Hypersensitivity; Electrocardiography; Electromyography; Female; Halothane; Humans; Male; Malignant Hyperthermia; Microscopy, Electron; Middle Aged; Muscles; Pedigree; Potassium Chloride; Sarcoplasmic Reticulum; Succinylcholine; Temperature | 1974 |
Genotype-phenotype comparison of the Swiss malignant hyperthermia population.
Topics: Caffeine; DNA Mutational Analysis; Gene Frequency; Genetic Heterogeneity; Genetic Predisposition to Disease; Genetic Testing; Genotype; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Mutation; Phenotype; Polymorphism, Single-Stranded Conformational; Ryanodine Receptor Calcium Release Channel; Switzerland | 2001 |
Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility.
Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Sensitivity and Specificity | 2003 |
341 other study(ies) available for halothane and caffeine
| Article | Year |
|---|---|
Computation of brain-blood partitioning of organic solutes via free energy calculations.
Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics | 1996 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A laboratory animal model for malignant hyperpyrexia.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Caffeine; Disease Models, Animal; Drug Interactions; Halothane; Hydrogen-Ion Concentration; Male; Malignant Hyperthermia; Pentobarbital; Rabbits; Time Factors | 1979 |
Isometric contraction of skeletal muscle of malignant hyperthermia (MH) susceptible and resistant Belgian landrace pigs under the influence of several drugs.
Topics: Animals; Caffeine; Halothane; Hypothermia; Hypothermia, Induced; In Vitro Techniques; Muscle Contraction; Swine; Swine Diseases | 1978 |
Malignant hyperthermia.
Topics: Alleles; Anesthesia, General; Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscles | 1978 |
Sites and mechanisms of action of halothane on skeletal muscle function in vitro.
Topics: Animals; Caffeine; Diaphragm; Dose-Response Relationship, Drug; Glycerol; Halothane; Male; Muscle Contraction; Muscles; Potassium Chloride; Rats | 1979 |
Identification of susceptibility to malignant hyperpyrexia in swine.
Topics: Animals; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Succinylcholine; Swine; Thymol | 1979 |
In vivo neutron activation analysis for bone calcium (INVAA) in malignant hyperthermia susceptible patients.
Topics: Adult; Age Factors; Bone and Bones; Caffeine; Calcium; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscles; Neutron Activation Analysis; Sex Factors | 1979 |
Does prior dantrolene affect the in vitro diagnosis of malignant hyperthermia susceptibility?
Topics: Animals; Biopsy; Caffeine; Dantrolene; Drug Interactions; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Swine; Time Factors | 1979 |
Malignant hyperthermia: diagnosis, treatment and investigations of a skeletal muscle lesion.
Topics: Anesthetics; Animals; Caffeine; Diagnosis, Differential; Disease Models, Animal; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Masseter Muscle; Muscle Contraction; Muscles; Spasm; Succinylcholine; Swine | 1979 |
Effects of halothane on caffeine-induced tension transients in functionally skinned myocardial fibers.
Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Myocardium; Rabbits; Sarcoplasmic Reticulum | 1979 |
Is malignant hyperpyrexia muscle denervated?
Topics: Animals; Caffeine; Calcium; Evoked Potentials; Female; Halothane; Humans; In Vitro Techniques; Membrane Potentials; Mice; Models, Neurological; Muscle Contraction; Muscle Denervation; Muscles; Muscular Dystrophies; Succinylcholine | 1977 |
Screening for malignant hyperpyrexia.
Topics: Caffeine; Dose-Response Relationship, Drug; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Mass Screening; Muscle Contraction | 1977 |
The adenosine triphosphate (ATP) depletion test: comparison with the caffeine contracture test as a method of diagnosing malignant hyperthermia susceptibility.
Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Biopsy; Caffeine; Carbon Dioxide; Child; Dose-Response Relationship, Drug; Halothane; Humans; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle Tonus; Muscles; Oxygen | 1976 |
Porcine malignant hyperthermia: effects of temperature and extracellular calcium concentration on halothane-induced contracture of susceptible skeletal muscle.
Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Swine; Temperature; Time Factors; Transducers | 1975 |
An evaluation of procaine in the treatment of malignant hyperpyrexia.
Topics: Anesthesia, General; Animals; Caffeine; Contracture; Dose-Response Relationship, Drug; Drug Evaluation; Halothane; Humans; In Vitro Techniques; Lidocaine; Male; Malignant Hyperthermia; Muscle Contraction; Perfusion; Procaine; Rats | 1975 |
Porcine malignant hyperthermia: effect of dantrolene sodium on in-vitro halothane-induced contraction of susceptible muscle.
Topics: Animals; Caffeine; Calcium; Contracture; Dantrolene; Halothane; Hydantoins; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Sarcoplasmic Reticulum; Swine | 1976 |
Oxygen consumption by human and rodent striated muscle in vitro.
Topics: Animals; Biological Transport, Active; Caffeine; Diaphragm; Halothane; Humans; In Vitro Techniques; Insulin; Muscles; Osmolar Concentration; Ouabain; Oxygen Consumption; Potassium; Rats; Sodium | 1976 |
W-7, a calmodulin antagonist, and contracture of malignant hyperthermia susceptible skeletal muscle.
Topics: Animals; Caffeine; Calcium; Calmodulin; Dantrolene; Drug Synergism; Halothane; Intercellular Signaling Peptides and Proteins; Malignant Hyperthermia; Muscle Contraction; Peptides; Sulfonamides; Swine; Wasp Venoms | 1992 |
Left ventricular hypertrophy in rabbits does not exaggerate the effects of halothane on the intracellular components of cardiac contraction.
Topics: Animals; Body Weight; Caffeine; Calcium; Cardiomegaly; Halothane; Male; Myocardial Contraction; Organ Size; Rabbits; Sarcoplasmic Reticulum | 1992 |
Sources of variability in halothane and caffeine contracture tests for susceptibility to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Caffeine; Child; Contracture; Dose-Response Relationship, Drug; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscles; Sensitivity and Specificity; Time Factors | 1992 |
Na(+)-Ca2+ exchange influences halothane and caffeine contractures of malignant hyperthermic skeletal muscle.
Topics: Animals; Caffeine; Calcium; Carrier Proteins; Culture Media; Halothane; Kinetics; Malignant Hyperthermia; Membrane Proteins; Muscle Contraction; Muscles; Sodium; Sodium-Calcium Exchanger; Swine | 1992 |
Evaluation of greyhound susceptibility to malignant hyperthermia using halothane-succinylcholine anesthesia and caffeine-halothane muscle contractures.
Topics: Anesthesia, Inhalation; Animals; Caffeine; Disease Susceptibility; Dog Diseases; Dogs; Genetic Predisposition to Disease; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Species Specificity; Succinylcholine | 1992 |
Is the "K-type" caffeine-halothane responder susceptible to malignant hyperthermia?
Topics: Caffeine; Culture Techniques; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Phenotype | 1992 |
Propofol anaesthesia in malignant hyperpyrexia susceptible swine.
Topics: Anesthesia; Animals; Caffeine; Female; Halothane; Injections, Intravenous; Male; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Propofol; Swine | 1992 |
Propofol is a 'safe' anaesthetic agent in malignant hyperthermia susceptible patients.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Caffeine; Contracture; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscles; Propofol | 1992 |
[Effects of halothane, caffeine and ryanodine on the intracellular calcium store in blood mononuclear cells].
Topics: Animals; Caffeine; Calcium; Disease Susceptibility; Halothane; Humans; Leukocytes, Mononuclear; Malignant Hyperthermia; Models, Biological; Ryanodine | 1992 |
Abnormal rapid Ca2+ release from sarcoplasmic reticulum of malignant hyperthermia susceptible pigs.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Caffeine; Calcium; Calcium Channels; Filtration; Halothane; Kinetics; Magnesium; Malignant Hyperthermia; Ryanodine; Sarcoplasmic Reticulum; Swine | 1991 |
Interactions of fatty acids with the calcium release channel in malignant hyperthermia.
Topics: Animals; Caffeine; Calcium Channels; Fatty Acids; Halothane; Horses; Humans; Isoproterenol; Lipase; Malignant Hyperthermia; Muscle Proteins; Phenytoin; Ryanodine; Succinylcholine; Swine; Triglycerides | 1991 |
Evidence for related myopathies in exertional heat stroke and malignant hyperthermia.
Topics: Adult; Biopsy; Caffeine; Disease Susceptibility; Family Health; Female; Halothane; Heat Exhaustion; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Military Personnel; Muscle Contraction; Muscles; Muscular Diseases; Physical Exertion; Ryanodine | 1991 |
Use of the calcium agonist BAY K 8644 for in vitro diagnosis of susceptibility to malignant hyperthermia.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Caffeine; Disease Susceptibility; Drug Synergism; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction | 1990 |
BAY K 8644 and nifedipine alter halothane but not caffeine contractures of malignant hyperthermic muscle fibers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Caffeine; Calcium; Halothane; Malignant Hyperthermia; Muscle Contraction; Muscles; Nifedipine; Swine | 1991 |
Effects of BAY K 8644, nifedipine, and low Ca2+ on halothane and caffeine potentiation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Caffeine; Calcium; Drug Synergism; Halothane; In Vitro Techniques; Muscle Contraction; Muscles; Nifedipine; Swine | 1991 |
Is resting membrane potential a possible indicator of viability of muscle bundles used in the in vitro caffeine contracture test?
Topics: Caffeine; Electric Stimulation; Halothane; Humans; Malignant Hyperthermia; Membrane Potentials; Muscle Contraction; Muscles | 1992 |
In vitro contracture tests in patients with various neuromuscular diseases.
Topics: Adolescent; Adult; Aged; Caffeine; Child; Child, Preschool; Disease Susceptibility; Drug Hypersensitivity; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Neuromuscular Diseases; Sensory Thresholds | 1992 |
Halothane alters control of intracellular Ca2+ mobilization in single rat ventricular myocytes.
Topics: Animals; Caffeine; Calcium; Electric Stimulation; Female; Halothane; Heart Ventricles; Myocardial Contraction; Myocardium; Potassium; Rats; Rats, Inbred Strains | 1991 |
Effects of ketamine, thiopental sodium and propofol on muscle contractures in rat diaphragm in vitro.
Topics: Animals; Caffeine; Diaphragm; Drug Synergism; Female; Halothane; In Vitro Techniques; Ketamine; Male; Muscle Contraction; Propofol; Rats; Thiopental | 1991 |
Effects of volatile anesthetics on the intracellular Ca2+ concentration in cardiac muscle cells.
Topics: Anesthetics; Animals; Caffeine; Calcium; Cytosol; Electric Stimulation; Enflurane; Female; Fura-2; Halothane; Heart; In Vitro Techniques; Isoflurane; Membranes; Myocardium; Potassium; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1991 |
Why does halothane relax cardiac muscle but contract malignant hyperthermic skeletal muscle?
Topics: Animals; Caffeine; Calcium; Depression, Chemical; Fura-2; Halothane; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Muscles; Myocardial Contraction; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Swine | 1991 |
A substitution of cysteine for arginine 614 in the ryanodine receptor is potentially causative of human malignant hyperthermia.
Topics: Adolescent; Amino Acid Sequence; Arginine; Base Sequence; Caffeine; Cloning, Molecular; Cysteine; Exons; Female; Halothane; Humans; Male; Malignant Hyperthermia; Molecular Sequence Data; Muscle Proteins; Mutation; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Receptors, Cholinergic; Restriction Mapping; Ryanodine Receptor Calcium Release Channel; White People | 1991 |
[A new emphasis on the diagnosis of malignant hyperthermia using the in vitro contracture test?].
Topics: Adolescent; Adult; Caffeine; Child; Child, Preschool; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Infant; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Retrospective Studies | 1991 |
[Diagnosis of malignant hyperthermia. The platelet test versus the in vitro contracture test].
Topics: Blood Platelets; Caffeine; Child; Disease Susceptibility; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction | 1991 |
[In vitro diagnosis of malignant hyperpyrexia syndrome].
Topics: Adult; Caffeine; Dantrolene; Female; Halothane; Hernia, Inguinal; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Muscles | 1991 |
In vitro contraction test for malignant hyperthermia in patients with unexplained recurrent rhabdomyolysis.
Topics: Adult; Caffeine; Calcium; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscles; Pedigree; Rhabdomyolysis | 1991 |
The effect of azumolene on hypercontractility and sarcoplasmic reticulum Ca(2+)-dependent ATPase activity of malignant hyperpyrexia-susceptible porcine skeletal muscle.
Topics: Animals; Caffeine; Calcium-Transporting ATPases; Dantrolene; Halothane; Imidazoles; Malignant Hyperthermia; Muscle Contraction; Muscle Relaxants, Central; Muscles; Oxazoles; Potassium Chloride; Sarcoplasmic Reticulum | 1991 |
In vitro contracture testing for determination of susceptibility to malignant hyperthermia: a methodologic update.
Topics: Caffeine; Chromatography, Gas; Contracture; Diffusion Chambers, Culture; Disease Susceptibility; Electric Stimulation; Equipment Design; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscles; Rheology; Spectrophotometry; Time Factors; Transducers | 1991 |
Pharmacogenetics of caffeine and caffeine-halothane contractures in biopsies of human skeletal muscle.
Topics: Adolescent; Adult; Aged; Aging; Caffeine; Child; Child, Preschool; Female; Genetic Variation; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Sex Characteristics | 1991 |
Effects of caffeine, halothane, succinylcholine, phenylephrine and isoproterenol on myocardial force of contraction of malignant hyperthermia susceptible swine.
Topics: Animals; Caffeine; Disease Susceptibility; Halothane; Isoproterenol; Malignant Hyperthermia; Myocardial Contraction; Phenylephrine; Stimulation, Chemical; Succinylcholine; Swine | 1991 |
Characterization of swine susceptible to malignant hyperthermia by in vivo, in vitro and post-mortem techniques.
Topics: Administration, Inhalation; Animals; Caffeine; Creatine Kinase; Disease Susceptibility; Genotype; Halothane; Heterozygote; Homozygote; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Swine | 1991 |
Malignant hyperthermia: normal muscle calcium uptake and abnormal caffeine and halothane contractures.
Topics: Adult; Biopsy; Caffeine; Calcium; Disease Susceptibility; False Negative Reactions; Female; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscles | 1991 |
Negative halothane-caffeine contracture test in mdx (dystrophin-deficient) mice.
Topics: Abdomen; Animals; Caffeine; Contracture; Drug Combinations; Dystrophin; Halothane; Mice; Mice, Mutant Strains; Osmolar Concentration | 1991 |
Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia.
Topics: Animals; Caffeine; Chromosomes, Human, Pair 19; Female; Genetic Linkage; Halothane; Heterozygote; Homozygote; Humans; Lod Score; Male; Malignant Hyperthermia; Muscle Contraction; Mutation; Pedigree; Polymorphism, Restriction Fragment Length; Receptors, Cholinergic; Ryanodine Receptor Calcium Release Channel; Swine | 1990 |
Calcium handling by platelets from normal and malignant hyperthermia-susceptible pigs.
Topics: Animals; Biological Transport; Blood Platelets; Caffeine; Calcium; Halothane; Malignant Hyperthermia; Swine | 1991 |
Malignant hyperthermia in dogs.
Topics: Animals; Biopsy; Caffeine; Crosses, Genetic; Dantrolene; Dog Diseases; Dogs; Female; Halothane; Heart Rate; Male; Malignant Hyperthermia; Muscle Contraction; Pedigree | 1991 |
[Diagnosis of susceptibility for malignant hyperthermia using in-vitro muscle contraction testing in Switzerland].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Caffeine; Child; Female; Genetic Predisposition to Disease; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscles | 1991 |
Effects of the anesthetics heptanol, halothane and isoflurane on gap junction conductance in crayfish septate axons: a calcium- and hydrogen-independent phenomenon potentiated by caffeine and theophylline, and inhibited by 4-aminopyridine.
Topics: 4-Aminopyridine; Alcohols; Anesthetics; Animals; Astacoidea; Axons; Caffeine; Calcium; Electric Conductivity; Halothane; Heptanol; Hydrogen-Ion Concentration; Intercellular Junctions; Isoflurane; Kinetics; Membrane Potentials; Theophylline | 1991 |
Molecular genetics and malignant hyperthermia.
Topics: Caffeine; Genetic Markers; Halothane; Humans; Malignant Hyperthermia; Molecular Biology | 1991 |
A comparison of the caffeine halothane muscle contracture test with the molecular genetic diagnosis of malignant hyperthermia.
Topics: Alleles; Caffeine; Child; Female; Genetic Linkage; Genetic Markers; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Polymorphism, Genetic; Receptors, Cholinergic; Ryanodine Receptor Calcium Release Channel | 1991 |
Halothane-dependent release of intracellular Ca2+ in blood cells in malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Cytosol; Disease Susceptibility; Egtazic Acid; Halothane; Humans; Malignant Hyperthermia; Monocytes; Muscle Contraction; Muscles; Swine; Swine Diseases | 1990 |
[Do neuroleptic malignant syndrome and malignant hyperthermia of anesthesia share a common mechanism?].
Topics: Caffeine; Halothane; Humans; Malignant Hyperthermia; Neuroleptic Malignant Syndrome | 1990 |
Microassay for malignant hyperthermia susceptibility: hypersensitive ligand-gating of the Ca channel in muscle sarcoplasmic reticulum causes increased amounts and rates of Ca-release.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels; Halothane; Ion Channel Gating; Kinetics; Ligands; Malignant Hyperthermia; Sarcoplasmic Reticulum; Swine | 1990 |
The importance of calcium ions for in vitro malignant hyperthermia testing.
Topics: Caffeine; Calcium; Contracture; Drug Interactions; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Nifedipine; Quinacrine; Strontium; Succinylcholine; Verapamil | 1990 |
Inappropriate use of the t-test.
Topics: Animals; Caffeine; Halothane; Malignant Hyperthermia; Statistics as Topic; Swine | 1990 |
Halothane cooling contractures of skinned mammalian muscle fibers.
Topics: Action Potentials; Animals; Caffeine; Calcium; Cold Temperature; Halothane; In Vitro Techniques; Lidocaine; Muscle Contraction; Muscles; Procaine; Rabbits; Sarcoplasmic Reticulum | 1990 |
Are myotonias and periodic paralyses associated with susceptibility to malignant hyperthermia?
Topics: Biopsy; Caffeine; Calcium; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Myotonia; Paralyses, Familial Periodic | 1990 |
Importance of fasting in the lymphocyte calcium test for malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Caffeine; Calcium; Contracture; Cytoplasm; Fasting; Female; Halothane; Humans; Lymphocytes; Male; Malignant Hyperthermia; Middle Aged; Muscles | 1990 |
Influence of salbutamol on the in vitro muscle response to caffeine and halothane in malignant hyperthermia.
Topics: Adult; Albuterol; Caffeine; Contracture; Dose-Response Relationship, Drug; Drug Interactions; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscles | 1990 |
Caffeine and halothane contracture testing in swine using the recommendations of the North American Malignant Hyperthermia Group.
Topics: Animals; Caffeine; Disease Susceptibility; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Swine | 1990 |
Localization of the malignant hyperthermia susceptibility locus to human chromosome 19q12-13.2.
Topics: Animals; Caffeine; Chromosome Mapping; Chromosomes, Human, Pair 19; Female; Genetic Linkage; Halothane; Humans; Lod Score; Male; Malignant Hyperthermia; Muscle Contraction; Pedigree; Receptors, Cholinergic; Recombination, Genetic; Ryanodine Receptor Calcium Release Channel; Swine | 1990 |
Clinical concentrations of verapamil affect the in vitro diagnosis of susceptibility to malignant hyperpyrexia.
Topics: Caffeine; Disease Susceptibility; False Negative Reactions; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Sensory Thresholds; Verapamil | 1990 |
Safety of general anesthesia in patients previously tested negative for malignant hyperthermia susceptibility.
Topics: Anesthesia, General; Caffeine; Contracture; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia | 1990 |
Malignant hyperthermia in the otolaryngologic patient: prospective anesthetic and surgical management of eight children.
Topics: Adenoidectomy; Anesthesia, General; Anxiety; Caffeine; Child; Child, Preschool; Contracture; Female; Halothane; Humans; Infant; Male; Malignant Hyperthermia; Middle Ear Ventilation; Nitrous Oxide; Preanesthetic Medication; Prospective Studies; Tonsillectomy | 1990 |
Contracture test and histologic and histochemical analyses of muscle biopsy specimens from horses with exertional rhabdomyolysis.
Topics: Anesthesia; Animals; Biopsy, Needle; Caffeine; Contracture; Female; Fever; Halothane; Horse Diseases; Horses; Male; Physical Exertion; Rhabdomyolysis | 1990 |
An association between certain congenital abnormalities and the malignant hyperthermia trait.
Topics: Adolescent; Adult; Caffeine; Child; Child, Preschool; Congenital Abnormalities; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscles | 1990 |
Current diagnostic methods of malignant hyperthermia: an evaluation.
Topics: Caffeine; Chromosomes, Human, Pair 19; Disease Susceptibility; Halothane; Humans; Magnetic Resonance Spectroscopy; Malignant Hyperthermia; Muscle Contraction | 1990 |
Effects of the calcium antagonist, TMB-8 on halothane and on caffeine contractures of malignant hyperthermia susceptible skeletal muscle.
Topics: Animals; Caffeine; Calcium Channel Blockers; Gallic Acid; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Swine | 1990 |
Compensatory increase in calcium extrusion activity of untreated lymphocytes from swine susceptible to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Disease Susceptibility; Halothane; Lymphocytes; Malignant Hyperthermia; Muscle Contraction; Swine; Swine Diseases | 1990 |
Alterations in the functional properties of skinned fibers from denervated rabbit skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Halothane; In Vitro Techniques; Muscle Contraction; Muscle Denervation; Muscles; Rabbits; Sarcoplasmic Reticulum | 1990 |
Abnormal membrane properties of the sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia: modes of action of halothane, caffeine, dantrolene, and two other drugs.
Topics: Animals; Caffeine; Calcium; Dantrolene; Electron Spin Resonance Spectroscopy; Halothane; Intracellular Membranes; Malignant Hyperthermia; Microsomes; Permeability; Ruthenium Red; Sarcoplasmic Reticulum; Swine; Tetracaine | 1986 |
Effects of halothane, caffeine, dantrolene and tetracaine on the calcium permeability of skeletal sarcoplasmic reticulum of malignant hyperthermic pigs.
Topics: Animals; Caffeine; Calcium; Cell Membrane Permeability; Dantrolene; Halothane; Kinetics; Malignant Hyperthermia; Ruthenium Red; Sarcoplasmic Reticulum; Swine; Tetracaine | 1987 |
Drug-induced Ca2+ release from isolated sarcoplasmic reticulum. II. Releases involving a Ca2+-induced Ca2+ release channel.
Topics: Animals; Caffeine; Calcium; Halothane; Ion Channels; Miconazole; Rabbits; Ruthenium Red; Ryanodine; Sarcoplasmic Reticulum; Sulfonamides; Tetracaine; Thymol | 1987 |
[Central core disease associated with malignant hyperthermia sensitivity].
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Child; Child, Preschool; Creatine Kinase; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Neuromuscular Diseases; Pedigree | 1989 |
Malignant hyperthermia: slow sodium current in cultured human muscle cells.
Topics: Caffeine; Cells, Cultured; Disease Susceptibility; Electric Conductivity; Halothane; Humans; Malignant Hyperthermia; Membrane Potentials; Muscle Contraction; Muscles; Sodium Channels | 1989 |
The association between the neuroleptic malignant syndrome and malignant hyperthermia.
Topics: Adult; Caffeine; Chlorpromazine; Contracture; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Neuroleptic Malignant Syndrome | 1989 |
Effect of diltiazem, verapamil and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible human skeletal muscle.
Topics: Caffeine; Dantrolene; Diltiazem; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Verapamil | 1989 |
[The action of ketamine on muscle contractile behavior. In vitro studies on the musculature of subjects susceptible to malignant hyperthermia].
Topics: Caffeine; Disease Susceptibility; Halothane; In Vitro Techniques; Ketamine; Malignant Hyperthermia; Muscle Contraction | 1989 |
The use of Fura-2 to estimate myoplasmic [Ca2+] in human skeletal muscle.
Topics: Benzofurans; Caffeine; Calcium; Chromatography, High Pressure Liquid; Fura-2; Halothane; Humans; In Vitro Techniques; Muscles; Muscular Diseases; Spectrometry, Fluorescence | 1989 |
[Malignant hyperthermia; two cases of MH in the presence of general anesthesia and performing caffeine contracture test].
Topics: Adult; Caffeine; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction | 1989 |
The in vitro determination of susceptibility to malignant hyperthermia.
Topics: Animals; Caffeine; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Swine | 1989 |
31P-NMR spectroscopy: the metabolic profile of malignant hyperpyrexic porcine skeletal muscle.
Topics: Animals; Caffeine; Halothane; Magnetic Resonance Imaging; Malignant Hyperthermia; Muscles; Phosphorus; Swine | 1989 |
Effects of droperidol, haloperidol and ketamine on halothane, succinylcholine and caffeine contractures: implications for malignant hyperthermia.
Topics: Animals; Caffeine; Contracture; Droperidol; Haloperidol; Halothane; Humans; Ketamine; Male; Malignant Hyperthermia; Rats; Rats, Inbred Strains; Succinylcholine | 1989 |
Volatile anesthetics decrease calcium content of isolated myocytes.
Topics: Animals; Caffeine; Calcium; Depression, Chemical; Enflurane; Halothane; In Vitro Techniques; Isoflurane; Male; Myocardium; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum | 1989 |
Effect of diltiazem and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible porcine skeletal muscle.
Topics: Animals; Caffeine; Dantrolene; Diltiazem; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Swine | 1989 |
Comparison of the effects of halothane on skinned myocardial fibers from newborn and adult rabbit: II. Effects on sarcoplasmic reticulum.
Topics: Aging; Animals; Animals, Newborn; Caffeine; Calcium; Halothane; Heart; In Vitro Techniques; Male; Myocardium; Rabbits; Sarcoplasmic Reticulum | 1989 |
Inhalation anaesthetics decrease calcium content of cardiac sarcoplasmic reticulum.
Topics: Anesthetics; Animals; Caffeine; Calcium; Enflurane; Halothane; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum | 1989 |
Intracellular mechanisms of halothane's effect on isolated aortic strips of the rabbit.
Topics: Acetylcholine; Animals; Aorta; Caffeine; Calcium; Endothelium, Vascular; Halothane; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Perfusion; Potassium Chloride; Rabbits; Sarcoplasmic Reticulum; Vasodilation | 1989 |
Standards for halothane/caffeine contracture test.
Topics: Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction | 1989 |
Malignant hyperthermia in humans--standardization of contracture testing protocol.
Topics: Biopsy; Caffeine; Clinical Laboratory Techniques; Drug Combinations; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction | 1989 |
Fluoxetine treatment of a depressed patient susceptible to malignant hyperthermia.
Topics: Adolescent; Caffeine; Depressive Disorder; Disease Susceptibility; Female; Fluoxetine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction | 1989 |
Influence of propranolol on the in vitro response to caffeine and halothane in malignant hyperthermia-susceptible muscle.
Topics: Anesthesia; Caffeine; Disease Susceptibility; Dose-Response Relationship, Drug; Drug Interactions; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscles; Propranolol | 1989 |
Effects of the halothane-sensitivity gene on sarcoplasmic reticulum function.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Genes; Halothane; Kinetics; Malignant Hyperthermia; Muscles; Receptors, Cholinergic; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Species Specificity; Swine; Swine Diseases | 1989 |
Anaesthetic-induced increase in ionised calcium in blood mononuclear cells from malignant hyperthermia patients.
Topics: Aminoquinolines; Anesthetics; Caffeine; Calcium; Drug Evaluation; Halothane; Humans; In Vitro Techniques; Ions; Malignant Hyperthermia; Muscle Contraction | 1987 |
Ca-induced Ca release in malignant hyperthermia-susceptible pig skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Halothane; In Vitro Techniques; Kinetics; Malignant Hyperthermia; Muscles; Reference Values; Sarcoplasmic Reticulum; Swine; Swine Diseases | 1989 |
Prolongation of inhibitory postsynaptic currents by pentobarbitone, halothane and ketamine in CA1 pyramidal cells in rat hippocampus.
Topics: Animals; Caffeine; Electrophysiology; Ethanol; Halothane; Hippocampus; In Vitro Techniques; Ketamine; Nitrous Oxide; Pentobarbital; Rats; Synapses; Synaptic Transmission | 1985 |
[Contracture test with ionophore A 23187 for the diagnosis of malignant hyperthermia].
Topics: Adolescent; Adult; Caffeine; Calcimycin; Contracture; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscles | 1986 |
Malignant hyperthermia in plastic surgery.
Topics: Adult; Caffeine; Child; Child, Preschool; Dermoid Cyst; Disease Susceptibility; Facial Neoplasms; Female; Halothane; Humans; Male; Malignant Hyperthermia; Prospective Studies; Succinylcholine; Surgery, Plastic; Tendon Transfer | 1988 |
The effect of halothane on the free intracellular calcium concentration of isolated rat heart cells.
Topics: Aminoquinolines; Animals; Caffeine; Calcium; Cytoplasm; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Intracellular Membranes; Male; Myocardium; Osmolar Concentration; Rats; Rats, Inbred Strains | 1988 |
Effect of fiber types, fascicle size and halothane on caffeine contractures in rat muscles.
Topics: Animals; Caffeine; Halothane; In Vitro Techniques; Muscle Contraction; Muscles; Rats; Rats, Inbred Strains | 1988 |
Calmodulin-antagonist drugs and porcine malignant hyperpyrexia.
Topics: Animals; Caffeine; Calmodulin; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Phenothiazines; Potassium Chloride; Swine | 1988 |
Age, fiber type composition and in vitro contracture responses in human malignant hyperthermia.
Topics: Adolescent; Adult; Aging; Caffeine; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscles; Myofibrils | 1988 |
[Tests of contracture and sensitivity to malignant hyperthermia in 27 patients].
Topics: Adolescent; Adult; Anesthesia, General; Biopsy; Caffeine; Child; Child, Preschool; Contracture; Creatine Kinase; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscles; Risk Factors | 1988 |
Halothane-caffeine contracture testing in neuromuscular diseases.
Topics: Biopsy; Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscles; Neuromuscular Diseases; Risk Factors | 1988 |
Fura-2 detected myoplasmic calcium and its correlation with contracture force in skeletal muscle from normal and malignant hyperthermia susceptible pigs.
Topics: Animals; Benzofurans; Caffeine; Calcium; Disease Susceptibility; Fura-2; Halothane; Malignant Hyperthermia; Muscle Contraction; Muscles; Physical Exertion; Swine | 1988 |
[Malignant hyperthermia in Austria. II. A comparison of the results of diagnostic test procedures].
Topics: Adult; Caffeine; Creatine Kinase; Disease Susceptibility; Electromyography; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscles | 1988 |
Neuroleptic malignant syndrome and malignant hyperthermia. In vitro comparison with halothane and caffeine contracture tests.
Topics: Adult; Aged; Caffeine; Disease Susceptibility; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Neuroleptic Malignant Syndrome | 1987 |
Prediction of malignant hyperthermia susceptibility by clinical signs.
Topics: Adolescent; Anesthesia, General; Biopsy; Caffeine; Child; Halothane; Humans; Infant; Malignant Hyperthermia; Muscle Contraction; Muscles; Retrospective Studies; Succinylcholine; Sudden Infant Death | 1987 |
Abnormal relaxation rates in subjects susceptible to malignant hyperthermia.
Topics: Adolescent; Adult; Caffeine; Electromyography; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle Relaxation; Skin Temperature | 1987 |
Calcium uptake in frozen muscle biopsy sections compared with other predictors of malignant hyperthermia susceptibility.
Topics: Animals; Biopsy; Caffeine; Calcium; Cats; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscles | 1987 |
In vitro diagnosis of susceptibility to malignant hyperthermia: comparison between dynamic and static halothane and caffeine tests.
Topics: Caffeine; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles | 1987 |
In vitro diagnosis of susceptibility to malignant hyperthermia: evaluation of tests with halothane-caffeine, potassium chloride, suxamethonium and caffeine-suxamethonium.
Topics: Caffeine; Disease Susceptibility; Evaluation Studies as Topic; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Potassium Chloride; Succinylcholine | 1987 |
Selective inhibition by dantrolene of caffeine-induced catecholamine release from perfused dog adrenals.
Topics: Adrenal Glands; Animals; Caffeine; Catecholamines; Dantrolene; Dogs; Female; Halothane; In Vitro Techniques; Male; Perfusion | 1987 |
Halothane-cooling contractures of mammalian muscles.
Topics: Anesthetics, Local; Animals; Caffeine; Calcium; Cold Temperature; Dantrolene; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Malignant Hyperthermia; Mice; Muscle Contraction; Temperature | 1986 |
Static v. dynamic tests in the in vitro diagnosis of malignant hyperthermia susceptibility.
Topics: Caffeine; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction | 1986 |
[Contracture response to isoflurane and pentazocine in muscles of a patient with malignant hyperthermia].
Topics: Caffeine; Child; Halothane; Humans; In Vitro Techniques; Isoflurane; Male; Malignant Hyperthermia; Methyl Ethers; Muscle Contraction; Pentazocine | 1986 |
Action of halothane on rat soleus muscle: temperature dependent induction of contractures and modification of caffeine and potassium contractures.
Topics: Animals; Caffeine; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Female; Halothane; In Vitro Techniques; Muscle Contraction; Potassium; Rats; Rats, Inbred Strains; Temperature | 1986 |
Investigation of malignant hyperthermia in Sweden.
Topics: Adolescent; Adult; Aged; Caffeine; Child; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscles; Sweden | 1986 |
[Detection of peranesthetic malignant hyperthermia by muscle contracture tests and NMR spectroscopy].
Topics: Biopsy; Caffeine; Halothane; Humans; In Vitro Techniques; Magnetic Resonance Spectroscopy; Malignant Hyperthermia; Muscle Contraction; Muscles | 1986 |
Diagnosis of malignant hyperthermia: implications for the military.
Topics: Adolescent; Adult; Caffeine; Halothane; Humans; Male; Malignant Hyperthermia; Military Medicine; Muscle Contraction; Referral and Consultation | 1985 |
Malignant hyperthermia.
Topics: Adult; Anesthesia; Animals; Caffeine; Child; Creatine Kinase; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscles; Risk; Swine | 1985 |
Masseter muscle rigidity and malignant hyperthermia susceptibility.
Topics: Caffeine; Child; Creatine Kinase; Female; Halothane; Humans; Male; Malignant Hyperthermia; Masseter Muscle; Masticatory Muscles; Muscle Contraction; Muscle Rigidity; Succinylcholine | 1986 |
Failure of the platelet-halothane nucleotide depletion test as a diagnostic or screening test for malignant hyperthermia.
Topics: Blood Platelets; Caffeine; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Nucleotides | 1986 |
The temperature dependence of halothane-induced contractures of skeletal muscle.
Topics: Anesthetics, Local; Animals; Anura; Caffeine; Calcium; Disease Models, Animal; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Temperature | 1986 |
Porcine malignant hyperthermia: cell injury enhances halothane sensitivity of biopsies.
Topics: Animals; Caffeine; Disease Susceptibility; Halothane; Hybridization, Genetic; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Sarcoplasmic Reticulum; Swine | 1986 |
Verapamil and zero Ca2+ alter responses of cat muscle to halothane and caffeine.
Topics: Animals; Caffeine; Calcium; Cats; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Space; Halothane; Muscle Contraction; Muscles; Verapamil | 1986 |
Intracellular mechanism of action of isoflurane and halothane on striated muscle of the rabbit.
Topics: Animals; Caffeine; Calcium; Drug Interactions; Halothane; In Vitro Techniques; Isoflurane; Methyl Ethers; Muscle Contraction; Muscle, Smooth; Rabbits; Sarcoplasmic Reticulum | 1986 |
Electrophoresis of muscle proteins is not a method for diagnosis of malignant hyperthermia susceptibility.
Topics: Caffeine; Electrophoresis, Polyacrylamide Gel; Halothane; Humans; Malignant Hyperthermia; Molecular Weight; Muscle Contraction; Muscle Proteins; Sarcoplasmic Reticulum | 1986 |
In vitro responses of cat skeletal muscle to halothane and caffeine.
Topics: Animals; Caffeine; Cats; Dantrolene; Dose-Response Relationship, Drug; Electric Stimulation; Halothane; Hypertension, Malignant; Muscle Contraction; Muscles | 1985 |
Myoadenylate deaminase deficiency: inherited and acquired forms.
Topics: Adenylate Kinase; Ammonia; AMP Deaminase; Biopsy; Caffeine; Creatine Kinase; Female; Genetic Carrier Screening; Halothane; Homozygote; Humans; Isoenzymes; Lactates; Lactic Acid; Male; Muscle Contraction; Muscle Cramp; Muscles; Nucleotide Deaminases; Physical Exertion | 1985 |
Malignant hyperpyrexia and sudden death.
Topics: Adolescent; Adult; Caffeine; Death, Sudden; Disease Susceptibility; Halothane; Humans; Male; Malignant Hyperthermia; Muscles | 1985 |
In vitro interaction between halothane and succinylcholine in human skeletal muscle: implications for malignant hyperthermia and masseter muscle rigidity.
Topics: Caffeine; Disease Susceptibility; Drug Interactions; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Masseter Muscle; Masticatory Muscles; Muscle Contraction; Muscle Rigidity; Succinylcholine | 1985 |
Laboratory diagnosis of malignant hyperpyrexia susceptibility (MHS). European MH Group.
Topics: Caffeine; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia | 1985 |
Microcalorimetric studies in malignant hyperpyrexia susceptible individuals.
Topics: Blood Platelets; Body Temperature Regulation; Caffeine; Calorimetry; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscles | 1985 |
Diltiazem inhibits halothane-induced contractions in malignant hyperthermia-susceptible muscles in vitro.
Topics: Animals; Benzazepines; Caffeine; Depression, Chemical; Diltiazem; Disease Susceptibility; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Swine; Time Factors | 1985 |
Myoadenylate deaminase deficiency and malignant hyperthermia susceptibility: is there a relationship?
Topics: Adenylate Kinase; Adult; AMP Deaminase; Caffeine; Creatine Kinase; Disease Susceptibility; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Muscles; Nucleotide Deaminases | 1985 |
Metabolic error of muscle metabolism after recovery from malignant hyperthermia.
Topics: Adolescent; Adult; Anesthesia, General; Caffeine; Calcium; Contracture; Female; Fever; Halothane; Humans; In Vitro Techniques; Male; Metabolism, Inborn Errors; Muscle Contraction; Muscles | 1970 |
Letter: Procaine and malignant hyperthermia.
Topics: Animals; Caffeine; Drug Interactions; Guinea Pigs; Halothane; Malignant Hyperthermia; Muscle Rigidity; Muscles; Procaine | 1974 |
Malignant hyperthermia--an investigation of three patients.
Topics: Adenosine Triphosphatases; Anesthesia, General; Aspartate Aminotransferases; Body Temperature; Caffeine; Calcium; Electron Transport; Endoplasmic Reticulum; Fever; Genes, Dominant; Halothane; Humans; Mitochondria, Muscle; Muscle Contraction; Muscle Proteins; Muscles; Myoglobin; Oxidative Phosphorylation; Phosphates; Potassium; Spasm; Succinylcholine | 1971 |
Procaine in malignant hyperpyrexia.
Topics: Aged; Caffeine; Female; Halothane; Humans; In Vitro Techniques; Lidocaine; Malignant Hyperthermia; Muscle Contraction; Procaine; Relaxation | 1972 |
Histopathological and neuropharmacological aspects of malignant hyperpyrexia.
Topics: Adult; Anesthesia, General; Caffeine; Child; Child, Preschool; Creatine Kinase; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscular Diseases; Procaine | 1973 |
Recent advances in the understanding of anaesthetic-induced malignant hyperpyrexia.
Topics: Acidosis; Anesthetics; Animals; Anura; Bicarbonates; Caffeine; Calcium; Cold Temperature; Disease Models, Animal; Electrolytes; Enzymes; Halothane; Malignant Hyperthermia; Mannitol; Muscles; Procaine; Rats; Sarcoplasmic Reticulum; Succinylcholine; Swine; Tromethamine | 1973 |
Biochemical basis of malignant hyperpyrexia.
Topics: Biopsy; Caffeine; Calcium; Cell Membrane; Creatine Kinase; Extracellular Space; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Models, Biological; Muscle Contraction; Muscles; Potassium Chloride; Procaine; Sarcolemma; Sarcoplasmic Reticulum; Succinylcholine; Temperature | 1974 |
An in-vitro model of anesthetic hypertonic hyperpyrexia, halothane--caffeine-induced muscle contractures: prevention of contracture by procainamide.
Topics: Anesthesia, Inhalation; Animals; Anura; Caffeine; Culture Techniques; Drug Synergism; Fever; Halothane; Lidocaine; Models, Biological; Muscle Contraction; Procainamide; Rana pipiens; Sarcoplasmic Reticulum; Time Factors | 1971 |
A case of neuroleptic malignant syndrome: in vitro muscle comparison with malignant hyperthermia.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Caffeine; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscles | 1982 |
Neuroleptic malignant syndrome and malignant hyperthermia.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Caffeine; Fever; Fluphenazine; Halothane; Humans; Muscle Contraction; Syndrome | 1983 |
Effects of midazolam on directly stimulated muscle biopsies from control and malignant hyperthermia positive patients.
Topics: Anti-Anxiety Agents; Benzodiazepines; Caffeine; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Midazolam; Muscle Contraction; Muscles; Preanesthetic Medication | 1984 |
Characterization of Ca2+ release from the cardiac sarcoplasmic reticulum.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Radioisotopes; Dogs; Ether; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Myocardium; Peptide Hydrolases; Phospholipases; Sarcoplasmic Reticulum; Temperature | 1983 |
Prolonged electromechanical coupling time intervals in skeletal muscle of pigs susceptible to malignant hyperthermia.
Topics: Animals; Caffeine; Disease Models, Animal; Electric Stimulation; Halothane; Kinetics; Malignant Hyperthermia; Muscle Contraction; Muscles; Swine; Synaptic Transmission | 1983 |
Dantrolene does not block calcium pulse-induced calcium release from a putative calcium channel in sarcoplasmic reticulum from malignant hyperthermia and normal pig muscle.
Topics: Animals; Caffeine; Calcium; Dantrolene; Halothane; Ion Channels; Malignant Hyperthermia; Muscle Contraction; Sarcoplasmic Reticulum; Swine | 1984 |
Investigation of malignant hyperthermia in Denmark and Sweden.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Child; Creatine Kinase; Disease Susceptibility; Female; Genetic Testing; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscles; Surgical Procedures, Operative | 1984 |
A protocol for the investigation of malignant hyperpyrexia (MH) susceptibility. The European Malignant Hyperpyrexia Group.
Topics: Biopsy; Caffeine; Disease Susceptibility; Genetic Testing; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Methods; Muscle Contraction; Muscles | 1984 |
Electrodiagnostic tests in the detection of malignant hyperthermia.
Topics: Adolescent; Adult; Caffeine; Electric Stimulation; Electromyography; Evoked Potentials; Female; Halothane; Humans; Injections, Intramuscular; Male; Malignant Hyperthermia; Muscles; Succinylcholine | 1984 |
Halothane-succinylcholine induced masseter spasm: indicative of malignant hyperthermia susceptibility?
Topics: Caffeine; Child; Child, Preschool; Creatine Kinase; Female; Halothane; Humans; Male; Malignant Hyperthermia; Masseter Muscle; Masticatory Muscles; Muscle Contraction; Phenotype; Risk; Spasm; Succinylcholine | 1984 |
Thyroliberin (thyrotropin releasing hormone): antagonism of halothane and hexobarbital narcosis in mice. Comparison with pentetrazol, caffeine, d-amphetamine and adrenaline.
Topics: Animals; Caffeine; Dextroamphetamine; Dose-Response Relationship, Drug; Epinephrine; Halothane; Hexobarbital; Male; Mice; Mice, Inbred Strains; Pentylenetetrazole; Thyrotropin-Releasing Hormone | 1982 |
In vitro contracture tests for susceptibility to malignant hyperthermia.
Topics: Caffeine; Disease Susceptibility; Drug Interactions; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscle Rigidity; Muscles | 1983 |
Halothane-induced ATP depletion in platelets from patients susceptible to malignant hyperthermia and from controls.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adolescent; Adult; Blood Platelets; Caffeine; Child; Chromatography, High Pressure Liquid; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Potassium Chloride | 1983 |
Spectrum of susceptibility to malignant hyperthermia--diagnostic dilemma.
Topics: Animals; Body Temperature; Caffeine; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Lactates; Lactic Acid; Malignant Hyperthermia; Muscle Contraction; Phenotype; Preoperative Care; Swine; Swine, Miniature; Thiopental | 1983 |
Is theophylline, aminophylline, or caffeine (methylxanthines) contraindicated in malignant hyperthermia susceptible patients?
Topics: Adolescent; Adult; Aminophylline; Caffeine; Child; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Theophylline; Xanthines | 1983 |
The control of muscle contracture by the action of dantrolene on the sarcolemma.
Topics: Animals; Caffeine; Dantrolene; Diaphragm; Dinitrophenols; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Rats; Sarcolemma | 1983 |
Screening for malignant hyperthermia susceptibility.
Topics: Caffeine; Dantrolene; Halothane; Humans; Malignant Hyperthermia; Mass Screening; Muscle Contraction; Muscles | 1980 |
[Malignant hyperthermia-results of familial investigations in Austria (author's transl)].
Topics: Adenosine Triphosphate; Austria; Caffeine; Calcium; Chlorpromazine; Creatine Kinase; Halothane; Humans; In Vitro Techniques; Isoenzymes; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride | 1981 |
Mechanical properties of normal and malignant hyperthemia susceptible porcine muscle: effects of halothane and other drugs.
Topics: Animals; Anura; Caffeine; Drug Interactions; Epinephrine; Halothane; In Vitro Techniques; Male; Malignant Hyperthermia; Mice; Muscle Contraction; Norepinephrine; Rana pipiens; Succinylcholine; Swine | 1980 |
Masseter spasm induced by succinylcholine in children: contracture testing for malignant hyperthermia: report of six cases.
Topics: Anesthesia; Caffeine; Child; Child, Preschool; Halothane; Humans; Male; Malignant Hyperthermia; Masseter Muscle; Masticatory Muscles; Muscle Contraction; Muscles; Spasm; Succinylcholine | 1982 |
The in-vitro caffeine contracture test: influence of the muscle histochemical profile on test results.
Topics: Animals; Caffeine; Halothane; Histocytochemistry; Male; Malignant Hyperthermia; Muscle Contraction; Muscles; Rats | 1982 |
Pharmacological in-vitro studies in malignant hyperthermia in childhood.
Topics: Adolescent; Biopsy; Caffeine; Child; Child, Preschool; Dose-Response Relationship, Drug; Halothane; Humans; Infant; Malignant Hyperthermia; Muscle Contraction; Muscles; Neuromuscular Diseases | 1982 |
Comparison of the caffeine skinned fibre tension (CSFT) test with the caffeine-halothane contracture (CHC) test in the diagnosis of malignant hyperthermia.
Topics: Anesthesia; Caffeine; Calcium; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Sarcoplasmic Reticulum | 1982 |
The Ca-releasing action of halothane on fragmented sarcoplasmic reticulum.
Topics: Adenosine Triphosphate; Animals; Caffeine; Calcium; Halothane; Hydrogen-Ion Concentration; In Vitro Techniques; Magnesium; Procaine; Rabbits; Sarcoplasmic Reticulum; Temperature | 1982 |
Human malignant hyperthermia: awake episodes and correction by dantrolene.
Topics: Adenosine Triphosphate; Adult; Caffeine; Dantrolene; Fatigue; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Muscles; Stress, Physiological; Wakefulness | 1980 |
Effects of halothane on functionally skinned rabbit soleus muscle fibers: a correlation between tension transient and 45Ca release.
Topics: Animals; Caffeine; Calcium; Calcium Radioisotopes; Halothane; Muscle Contraction; Muscle Proteins; Muscles; Rabbits | 1980 |
Calcium content and contracture in isolated muscle of malignant hyperthermia in pigs.
Topics: Animals; Caffeine; Calcium; Halothane; In Vitro Techniques; Magnesium; Malignant Hyperthermia; Muscles; Osmolar Concentration; Swine | 1981 |
Temperature dependence of muscle function in malignant hyperpyrexia-susceptible swine.
Topics: Animals; Caffeine; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Succinylcholine; Swine; Temperature | 1981 |
Effect of temperature, time and fascicle size on the caffeine contracture test.
Topics: Caffeine; Dose-Response Relationship, Drug; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Temperature; Time | 1980 |
Contracture responses and energy stores in quadriceps muscle from humans age 7-82 years.
Topics: Adolescent; Adult; Aged; Aging; Caffeine; Child; Energy Metabolism; Halothane; Humans; Middle Aged; Muscle Contraction | 1980 |
Site of the muscle cell abnormality in swine susceptible to malignant hyperpyrexia.
Topics: Acetylcholine; Animals; Caffeine; Dantrolene; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Potassium Chloride; Swine; Thymol; Tubocurarine | 1980 |
Malignant hyperthermia susceptibility. A light and electron microscopic study of endomyocardial biopsy specimens from nine patients.
Topics: Adolescent; Adult; Caffeine; Cardiomyopathies; Female; Halothane; Heart Diseases; Humans; Male; Malignant Hyperthermia; Microscopy, Electron; Middle Aged; Myocardial Contraction; Myocardium | 1980 |
Characterization of the methylxanthine-induced propagated wave phenomenon in striated muscle.
Topics: Animals; Caffeine; Chick Embryo; Halothane; Histocytochemistry; Muscle Contraction; Muscles; Quinine; Theobromine; Theophylline | 1980 |
The point mutation Arg615-->Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia.
Topics: Amino Acid Sequence; Animals; Arginine; Blotting, Western; Caffeine; Calcium; Calcium Channels; Cell Line; Cysteine; Drug Hypersensitivity; Gene Library; Halothane; Intracellular Membranes; Malignant Hyperthermia; Mice; Microsomes; Muscle Proteins; Muscles; Point Mutation; Poly A; Rabbits; RNA; RNA, Messenger; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Transfection | 1994 |
Differential anesthetic-induced opening of calcium-dependent large conductance channels in isolated ventricular myocytes.
Topics: Anesthetics; Animals; Caffeine; Calcium; Guinea Pigs; Halothane; Heart Ventricles; In Vitro Techniques; Ion Channels; Isoflurane; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Ryanodine; Sarcoplasmic Reticulum | 1994 |
Genotype and phenotype relationships for mutations in the ryanodine receptor in patients referred for diagnosis of malignant hyperthermia.
Topics: Anesthetics, Inhalation; Caffeine; Calcium Channels; Central Nervous System Stimulants; DNA Mutational Analysis; Dose-Response Relationship, Drug; Genotype; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscle Proteins; Mutation; Phenotype; Ryanodine Receptor Calcium Release Channel | 1995 |
Effects of halothane on calcium(2+)-activated tension of the contractile proteins and calcium(2+) uptake and release by the sarcoplasmic reticulum in skinned human myocardial fibers.
Topics: Animals; Buffers; Caffeine; Calcium; Contractile Proteins; Dose-Response Relationship, Drug; Egtazic Acid; Halothane; Heart Ventricles; Humans; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nitrogen; Rabbits; Sarcoplasmic Reticulum | 1995 |
C1840-T mutation in the human skeletal muscle ryanodine receptor gene: frequency in northern German families susceptible to malignant hyperthermia and the relationship to in vitro contracture response.
Topics: Adolescent; Adult; Aged; Base Sequence; Caffeine; Calcium Channels; Child; Child, Preschool; Chromosomes, Human, Pair 19; Disease Susceptibility; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Point Mutation; Polymorphism, Genetic; Ryanodine; Ryanodine Receptor Calcium Release Channel | 1995 |
Effect of phenytoin on skeletal muscle from quarter horses with hyperkalaemic periodic paralysis.
Topics: Animals; Caffeine; Calcium; Halothane; Horse Diseases; Horses; Hyperkalemia; Muscle Contraction; Muscle, Skeletal; Paralysis; Phenytoin; Potassium | 1995 |
Effects of halothane and isoflurane on cytosolic calcium ion concentrations and contraction in the vascular smooth muscle of the rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Caffeine; Calcium; Calcium Channels; Cytosol; Dose-Response Relationship, Drug; Halothane; Isoflurane; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Rats; Rats, Sprague-Dawley; Ryanodine; Sarcoplasmic Reticulum | 1993 |
The effect of calcium channel antagonists and BAY K 8644 on calcium fluxes of malignant hyperpyrexia-susceptible muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Halothane; Malignant Hyperthermia; Muscle Contraction; Muscles; Nifedipine; Potassium Chloride; Sarcoplasmic Reticulum; Swine; Verapamil | 1993 |
Abnormal action potential responses to halothane in heart muscle isolated from malignant hyperthermia-susceptible pigs.
Topics: Action Potentials; Animals; Caffeine; Dose-Response Relationship, Drug; Electric Stimulation; Halothane; Heart; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle, Skeletal; Swine | 1995 |
Effect of cocaine on the contracture response to 1% halothane in patients undergoing diagnostic muscle biopsy for malignant hyperthermia.
Topics: Adult; Biopsy; Caffeine; Cocaine; Contracture; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal | 1995 |
[Lack of sensitivity to per-anesthetic malignant hyperthermia in 32 patients who developed neuroleptic malignant syndrome].
Topics: Adolescent; Adult; Aged; Anesthesia, General; Caffeine; Contracture; Creatine Kinase; Dantrolene; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Neuroleptic Malignant Syndrome | 1994 |
Incidence of malignant hyperthermia reactions in 2,214 patients undergoing muscle biopsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Conduction; Anesthesia, General; Biopsy; Caffeine; Child; Child, Preschool; Contracture; Dantrolene; Disease Susceptibility; Halothane; Humans; Incidence; Infant; Intraoperative Complications; Malignant Hyperthermia; Middle Aged; Muscle, Skeletal; Nerve Block; Retrospective Studies | 1995 |
Endothelium-independent vasoconstricting and vasodilating actions of halothane on rat mesenteric resistance blood vessels.
Topics: Animals; Caffeine; Drug Interactions; Endothelium, Vascular; Halothane; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Rats; Ryanodine; Vascular Resistance; Vasoconstriction; Vasodilation | 1995 |
Malignant hyperthermia during sevoflurane administration.
Topics: Adult; Anesthetics; Caffeine; Disease Susceptibility; Ethers; Female; Halothane; Humans; Malignant Hyperthermia; Methyl Ethers; Sevoflurane | 1995 |
Exercise induced hyperthermia in a racing greyhound.
Topics: Animals; Caffeine; Dog Diseases; Dogs; Exercise Test; Halothane; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Physical Exertion | 1994 |
Effects hypoxia/reoxygenation on intracellular calcium ion homeostasis in ventricular myocytes during halothane exposure.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cell Hypoxia; Female; Halothane; Heart Ventricles; Homeostasis; Myocardium; Rats; Rats, Sprague-Dawley | 1994 |
Gasoline vapors induce severe rhabdomyolysis.
Topics: Adult; Alcohol Drinking; Automobile Driving; Caffeine; Creatine Kinase; Gasoline; Halothane; Humans; Male; Muscle Contraction; Muscles; Rhabdomyolysis | 1994 |
Masseter muscle rigidity and malignant hyperthermia susceptibility in pediatric patients. An update on management and diagnosis.
Topics: Adolescent; Biopsy; Caffeine; Child; Child, Preschool; Creatine Kinase; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Masseter Muscle; Muscle Rigidity; Retrospective Studies | 1994 |
Genetic effects on the variability of the halothane and caffeine muscle contracture tests.
Topics: Adult; Biopsy; Caffeine; Child; Disease Susceptibility; Family; Fatal Outcome; Female; Halothane; Humans; Infant; Male; Malignant Hyperthermia; Muscle Contraction; Muscles; Pedigree | 1994 |
Halothane and enflurane constrict canine mesenteric arteries by releasing Ca2+ from intracellular Ca2+ stores.
Topics: Animals; Arginine; Caffeine; Calcium; Dogs; Enflurane; Fluorescent Dyes; Fura-2; Halothane; In Vitro Techniques; Indomethacin; Isometric Contraction; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Nitroarginine; Ryanodine; Spectrometry, Fluorescence; Vasoconstriction | 1994 |
Viability criterion of muscle bundles used in the in vitro contracture test in patients with neuromuscular diseases.
Topics: Caffeine; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Membrane Potentials; Muscle Contraction; Muscles; Neuromuscular Diseases | 1994 |
Malignant hyperthermia--diagnostic dilemma: false-negative contracture responses with halothane and caffeine alone.
Topics: Caffeine; Child; False Negative Reactions; Female; Halothane; Humans; Male; Malignant Hyperthermia | 1994 |
[Diagnosis of malignant hyperthermia susceptibility. 1. The significance of in vitro susceptibility tests].
Topics: Adult; Caffeine; Child; Child, Preschool; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Infant; Male; Malignant Hyperthermia; Retrospective Studies | 1993 |
[High purity ryanodine for in vitro diagnosis of malignant hyperthermia].
Topics: Adolescent; Adult; Caffeine; Child; Culture Techniques; Dose-Response Relationship, Drug; Female; Halothane; Humans; Isometric Contraction; Male; Malignant Hyperthermia; Middle Aged; Ryanodine | 1993 |
Combined caffeine-halothane test for malignant hyperthermia.
Topics: Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction | 1993 |
False-negative results with muscle caffeine halothane contracture testing for malignant hyperthermia.
Topics: Adolescent; Adult; Biopsy; Caffeine; Child, Preschool; False Negative Reactions; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscles | 1993 |
Caffeine contractures, twitch characteristics and the threshold for Ca(2+)-induced Ca2+ release in skeletal muscle from horses with chronic intermittent rhabdomyolysis.
Topics: Animals; Caffeine; Calcium; Female; Halothane; Horse Diseases; Horses; In Vitro Techniques; Male; Muscle Contraction; Muscles; Rhabdomyolysis | 1993 |
Improved noninvasive diagnostic testing for malignant hyperthermia susceptibility from a combination of metabolites determined in vivo with 31P-magnetic resonance spectroscopy.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Disease Susceptibility; Female; Halothane; Humans; Magnetic Resonance Imaging; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscles; Phosphorus | 1993 |
Comparison of in vitro contracture testing with ryanodine, halothane and caffeine in malignant hyperthermia and other neuromuscular disorders.
Topics: Caffeine; Disease Susceptibility; Dose-Response Relationship, Drug; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Neuromuscular Diseases; Ryanodine | 1993 |
On the nature of the link between malignant hyperthermia and exertional heatstroke.
Topics: Animals; Body Temperature Regulation; Caffeine; Calcium Channels; Disease Models, Animal; Disease Susceptibility; Energy Metabolism; France; Halothane; Heat Stroke; Humans; Malignant Hyperthermia; Military Personnel; Models, Biological; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Physical Exertion; Ryanodine Receptor Calcium Release Channel; Swine | 1995 |
Malignant hyperthermia in the otology patient: the UCLA experience.
Topics: Administration, Inhalation; Adult; Anesthetics; Caffeine; Child; Child, Preschool; Dantrolene; Female; Halothane; Humans; Infant; Male; Malignant Hyperthermia; Middle Ear Ventilation; Muscle Relaxants, Central; Otolaryngology; Otorhinolaryngologic Diseases; Oxygen Consumption | 1994 |
Comparison of the segregation of the RYR1 C1840T mutation with segregation of the caffeine/halothane contracture test results for malignant hyperthermia susceptibility in a large Manitoba Mennonite family.
Topics: Anesthetics, Inhalation; Caffeine; Disease Susceptibility; Female; Halothane; Heterozygote; Humans; Male; Malignant Hyperthermia; Manitoba; Middle Aged; Muscle Contraction; Muscle, Skeletal; Mutation; Pedigree | 1996 |
Caffeine-halothane accuracy in MH testing.
Topics: Caffeine; Drug Stability; Drug Storage; Halothane; Humans; Malignant Hyperthermia | 1995 |
Halothane constricts bovine pulmonary arteries by release of intracellular calcium.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium; Calcium Channel Blockers; Cattle; Halothane; In Vitro Techniques; Potassium; Pulmonary Artery; Vasoconstriction | 1996 |
Dual actions of halothane on intracellular calcium stores of vascular smooth muscle.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium; Halothane; Muscle, Smooth, Vascular; Procaine; Rats; Rats, Sprague-Dawley; Ryanodine; Sarcoplasmic Reticulum | 1996 |
Malignant hyperthermia suggestive hypermetabolic syndrome at emergence from anesthesia.
Topics: Caffeine; Child; Creatine Kinase; Diagnosis, Differential; Female; Halothane; Humans; Malignant Hyperthermia; Muscles; Myoglobin; Rhabdomyolysis | 1995 |
Malignant hyperthermia (MH) diagnostics: a comparison between the halothane-caffeine- and the ryanodine-contracture-test results in MH susceptible, normal and control muscle.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Child; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Ryanodine | 1996 |
Fulminant malignant hyperthermia associated with ketoacidotic diabetic coma.
Topics: Adult; Caffeine; Cresols; Dantrolene; Diabetic Coma; Diabetic Ketoacidosis; Fever; Halothane; Humans; Male; Muscle Relaxants, Central | 1996 |
Malignant hyperthermia.
Topics: Anesthesia, General; Caffeine; Counseling; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Masseter Muscle; Muscle Contraction; Muscle Rigidity; Safety | 1996 |
Rapid cooling contractures in rat skinned myocardium: effects of isoflurane and halothane.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium-Transporting ATPases; Cold Temperature; Halothane; Histological Techniques; Isoflurane; Male; Myocardial Contraction; Papillary Muscles; Rats; Rats, Inbred Strains; Saponins; Sarcolemma; Sarcoplasmic Reticulum; Time Factors | 1996 |
HSP72 expression in malignant hyperthermia and normal muscle following exposure to caffeine and halothane.
Topics: Animals; Caffeine; Fever; Halothane; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Muscle, Skeletal | 1997 |
Initial contractile response of isolated rat heart cells to halothane, enflurane, and isoflurane.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium; Cells, Cultured; Electric Conductivity; Enflurane; Halothane; Heart; Isoflurane; Male; Membrane Potentials; Myocardial Contraction; Patch-Clamp Techniques; Rats; Rats, Wistar | 1997 |
[Definition of a diagnostic score of malignant hyperthermia using P-31 magnetic resonance spectroscopy].
Topics: Caffeine; Contracture; Disease Susceptibility; Halothane; Humans; Magnetic Resonance Spectroscopy; Malignant Hyperthermia; Phosphorus Isotopes; Retrospective Studies | 1996 |
Reduced Mg2+ inhibition of Ca2+ release in muscle fibers of pigs susceptible to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Dantrolene; Genetic Predisposition to Disease; Genotype; Halothane; Magnesium; Malignant Hyperthermia; Muscle Contraction; Muscle Fibers, Skeletal; Osmolar Concentration; Swine | 1997 |
An analysis of the predictive probability of the in vitro contracture test for determining susceptibility to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Biopsy; Caffeine; Child; Contracture; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Middle Aged; Probability; Regression Analysis; Ryanodine | 1997 |
Different effects of halothane, isoflurane and sevoflurane on sarcoplasmic reticulum of vascular smooth muscle in dog mesenteric artery.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium; Dogs; Drug Synergism; Ethers; Halothane; In Vitro Techniques; Isoflurane; Mesenteric Arteries; Methyl Ethers; Muscle, Smooth, Vascular; Sarcoplasmic Reticulum; Sevoflurane; Vasoconstriction | 1997 |
Malignant hyperthermia testing in patients with persistently increased serum creatine kinase levels.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Biopsy, Needle; Caffeine; Child; Child, Preschool; Clinical Enzyme Tests; Creatine Kinase; Disease Susceptibility; Female; Halothane; Humans; In Vitro Techniques; Infant; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle, Skeletal | 1997 |
Recombination between the postulated CCD/MHE/MHS locus and RYR1 gene markers.
Topics: Alleles; Caffeine; Calcium Channels; Child, Preschool; Chromosomes, Human, Pair 19; Female; Genetic Linkage; Genetic Markers; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle Proteins; Myopathies, Nemaline; Pedigree; Recombination, Genetic; Ryanodine Receptor Calcium Release Channel | 1996 |
Effect of temperature variation (22 degrees C-44 degrees C) on halothane and caffeine contracture testing in normal humans.
Topics: Aged; Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Halothane; Humans; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle, Skeletal; Temperature | 1997 |
Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Cresols; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle, Skeletal; Sensitivity and Specificity | 1997 |
Clinical reassessment of malignant hyperthermia in Abitibi-Témiscamingue.
Topics: Adolescent; Adult; Caffeine; Child; Disease Susceptibility; Family Characteristics; Female; Halothane; Humans; Male; Malignant Hyperthermia; Pedigree; Quebec; Risk Assessment | 1997 |
Malignant hyperthermia susceptibility, an autosomal dominant disorder?
Topics: Adolescent; Adult; Caffeine; Calcium Channels; Child; Child, Preschool; Female; Genes, Dominant; Genetic Predisposition to Disease; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle Proteins; Muscle, Skeletal; Mutation; Ryanodine Receptor Calcium Release Channel | 1997 |
[Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients].
Topics: Adolescent; Adult; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Phenotype | 1997 |
Dystrophin deficient mdx muscle is not prone to MH susceptibility: an in vitro study.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Disease Susceptibility; Dystrophin; Halothane; Male; Malignant Hyperthermia; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle, Skeletal; Muscular Dystrophy, Animal | 1997 |
In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: results of testing patients surviving fulminant MH and unrelated low-risk subjects. The European Malignant Hyperthermia Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Biopsy; Caffeine; Child; Child, Preschool; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Risk Factors; Sensitivity and Specificity | 1997 |
4-Chloro-m-cresol test--a possible supplementary test for diagnosis of malignant hyperthermia susceptibility.
Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Dose-Response Relationship, Drug; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Ryanodine | 1997 |
Caffeine and halothane sensitivity of intracellular Ca2+ release is altered by 15 calcium release channel (ryanodine receptor) mutations associated with malignant hyperthermia and/or central core disease.
Topics: Animals; Caffeine; Calcium; Cell Line; DNA, Complementary; Halothane; Humans; Malignant Hyperthermia; Mutagenesis, Site-Directed; Myopathies, Nemaline; Rabbits; Recombinant Proteins; Ryanodine Receptor Calcium Release Channel | 1997 |
Reduced inhibitory effect of Mg2+ on ryanodine receptor-Ca2+ release channels in malignant hyperthermia.
Topics: Animals; Binding Sites; Biophysical Phenomena; Biophysics; Caffeine; Calcium; Halothane; Humans; In Vitro Techniques; Kinetics; Magnesium; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Osmolar Concentration; Point Mutation; Ryanodine Receptor Calcium Release Channel; Swine; Swine Diseases | 1997 |
The Israeli Diagnostic Center for Malignant Hyperthermia: 7-years' accumulated experience.
Topics: Academies and Institutes; Adult; Aged; Biopsy; Caffeine; Child; Electromyography; Female; Genetic Predisposition to Disease; Halothane; Humans; Israel; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle, Skeletal; Patient Selection; Referral and Consultation; Sensitivity and Specificity | 1997 |
Muscle biopsy for malignant hyperthermia screening in children.
Topics: Adolescent; Anesthetics, Inhalation; Biopsy; Caffeine; Central Nervous System Stimulants; Child; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle, Skeletal | 1997 |
The effects of the atypical antipsychotics clozapine, remoxipride and risperidone on the contractile characteristics of rat skeletal muscle in vitro.
Topics: Animals; Antipsychotic Agents; Caffeine; Clozapine; Dantrolene; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Halothane; In Vitro Techniques; Muscle Contraction; Muscle Relaxants, Central; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Remoxipride; Risperidone; Trifluoperazine | 1997 |
Discordance between malignant hyperthermia susceptibility and RYR1 mutation C1840T in two Scandinavian MH families exhibiting this mutation.
Topics: Anesthesia; Caffeine; Denmark; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Mutation; Pedigree; Phenotype; Ryanodine Receptor Calcium Release Channel; Sensitivity and Specificity; Sweden | 1997 |
The sensitivity and specificity of the caffeine-halothane contracture test: a report from the North American Malignant Hyperthermia Registry. The North American Malignant Hyperthermia Registry of MHAUS.
Topics: Adult; Caffeine; Contracture; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscles; Registries | 1998 |
Rhabdomyolysis after infection and taking a cold medicine in a patient who was susceptible to malignant hyperthermia.
Topics: Adult; Caffeine; Chlorpheniramine; Common Cold; Dantrolene; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Nonprescription Drugs; Phenylephrine; Phenylpropanolamine; Rhabdomyolysis; Virus Diseases | 1998 |
Effects of halothane on the sarcoplasmic reticulum Ca2+ stores and contractile proteins in rabbit pulmonary arteries.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium; Central Nervous System Stimulants; Contractile Proteins; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Dyes; Fura-2; Halothane; Male; Myosin Light Chains; Pulmonary Artery; Rabbits; Sarcoplasmic Reticulum | 1998 |
Rhabdomyolysis following severe physical exercise in a patient with predisposition to malignant hyperthermia.
Topics: Adult; Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Disease Susceptibility; Exercise; Halothane; Heat Stroke; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Rhabdomyolysis; Risk Factors | 1998 |
Mutation screening of the RYR1 gene and identification of two novel mutations in Italian malignant hyperthermia families.
Topics: Caffeine; DNA Primers; Female; Halothane; Humans; Italy; Male; Malignant Hyperthermia; Muscles; Myopathies, Nemaline; Pedigree; Point Mutation; Polymorphism, Genetic; Polymorphism, Single-Stranded Conformational; Ryanodine Receptor Calcium Release Channel | 1999 |
A mutation in the transmembrane/luminal domain of the ryanodine receptor is associated with abnormal Ca2+ release channel function and severe central core disease.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Caffeine; Calcium; Cell Line; Chromosome Mapping; Cloning, Organism; DNA, Complementary; Female; Genetic Markers; Genotype; Halothane; Humans; Male; Mexico; Mutagenesis, Site-Directed; Myopathies, Nemaline; Pedigree; Point Mutation; Polymorphism, Genetic; Rabbits; Recombinant Proteins; Ryanodine Receptor Calcium Release Channel; Transfection | 1999 |
[Malignant hyperthermia: difficulty in diagnosing susceptibility in Spain].
Topics: Anesthetics, Inhalation; Caffeine; Europe; Genetic Predisposition to Disease; Halothane; Humans; Infant; Intraoperative Complications; Male; Malignant Hyperthermia; Osteomyelitis; Registries; Societies, Medical; Spain | 1999 |
ATX II, a sodium channel toxin, sensitizes skeletal muscle to halothane, caffeine, and ryanodine.
Topics: Animals; Caffeine; Cnidarian Venoms; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Ryanodine; Sodium Channels | 1999 |
Comparison between the European and North American protocols for diagnosis of malignant hyperthermia susceptibility in humans.
Topics: Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Sensitivity and Specificity | 1999 |
Effects of halothane on mechanical response of skeletal muscle from malignant hyperthermia susceptible patients.
Topics: Anesthetics, Inhalation; Biopsy; Caffeine; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Membrane Potentials; Muscle Contraction; Muscle, Skeletal | 1998 |
Abnormal regulation of muscle contraction in horses with recurrent exertional rhabdomyolysis.
Topics: Anesthetics, Inhalation; Animals; Biopsy; Caffeine; Central Nervous System Stimulants; Female; Halothane; Horse Diseases; Horses; Male; Malignant Hyperthermia; Membrane Potentials; Muscle Contraction; Muscle, Skeletal; Pedigree; Physical Exertion; Potassium; Recurrence; Regression Analysis; Rhabdomyolysis | 1999 |
Caffeine- or halothane-induced contractures of masseter muscle are similar to those of vastus muscle in normal humans.
Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Contracture; Dose-Response Relationship, Drug; Female; Halothane; Humans; Male; Malignant Hyperthermia; Masseter Muscle; Middle Aged; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Sarcolemma | 1999 |
5-HT2 receptor antagonist-mediated inhibition of halothane-induced contractures in skeletal muscle specimens from malignant hyperthermia susceptible patients.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Caffeine; Child; Dose-Response Relationship, Drug; Drug Interactions; Halothane; Humans; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle, Skeletal; Ritanserin; Serotonin Antagonists; Time Factors | 1999 |
The effect of halothane on calcium release from human skinned masseter fiber is not an artifact.
Topics: Anesthetics, Inhalation; Artifacts; Caffeine; Calcium; Central Nervous System Stimulants; Halothane; Humans; Masseter Muscle; Muscle Fibers, Skeletal | 2000 |
In vivo whole-body resting energy expenditure and insulin action in human malignant hyperthermia.
Topics: Adult; Anesthetics, Inhalation; Basal Metabolism; Body Composition; Caffeine; Calorimetry, Indirect; Central Nervous System Stimulants; Fasting; Female; Glucose; Halothane; Humans; Insulin; Linear Models; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Patch-Clamp Techniques | 2000 |
Between-center variability of results of the in vitro contracture test for malignant hyperthermia susceptibility.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Biopsy; Caffeine; Female; Genetic Predisposition to Disease; Halothane; Humans; In Vitro Techniques; Leg; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle, Skeletal; Risk Factors | 2000 |
Inositol 1,4,5-trisphosphate synthesis in mononuclear white blood cells of malignant hyperthermia-susceptible and normal human beings, following in vitro exposure to halothane, caffeine and ryanodine.
Topics: Anesthetics, Inhalation; Caffeine; Cell Separation; Halothane; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Malignant Hyperthermia; Muscle Contraction; Neutrophils; Phosphodiesterase Inhibitors; Respiratory Muscles; Ryanodine | 2000 |
[Malignant hyperthermia susceptibility in 3 patients with malignant neuroleptic syndrome].
Topics: Adult; Caffeine; Contracture; Disease Susceptibility; Female; Halothane; Humans; Male; Malignant Hyperthermia; Neuroleptic Malignant Syndrome | 2000 |
An autosomal dominant congenital myopathy with cores and rods is associated with a neomutation in the RYR1 gene encoding the skeletal muscle ryanodine receptor.
Topics: Amino Acid Substitution; Caffeine; Calcium; Cell Line; DNA Mutational Analysis; Female; France; Genes, Dominant; Genetic Heterogeneity; Genetic Predisposition to Disease; Genetic Testing; Genotype; Halothane; Haplotypes; Humans; Lod Score; Male; Malignant Hyperthermia; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; Myopathies, Nemaline; Myopathy, Central Core; Pedigree; Polymorphism, Genetic; Ryanodine Receptor Calcium Release Channel | 2000 |
Xenon does not induce contracture in human malignant hyperthermia muscle.
Topics: Anesthetics, Inhalation; Caffeine; Culture Techniques; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genetic Predisposition to Disease; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Phosphodiesterase Inhibitors; Xenon | 2000 |
Homozygous and heterozygous Arg614Cys mutations (1840C-->T) in the ryanodine receptor gene co-segregate with malignant hyperthermia susceptibility in a German family.
Topics: Adult; Anesthetics, Inhalation; Caffeine; DNA Mutational Analysis; Female; Genetic Predisposition to Disease; Genotype; Halothane; Heterozygote; Homozygote; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Pedigree; Phenotype; Point Mutation; Ryanodine Receptor Calcium Release Channel | 2001 |
A noninvasive investigation of muscle energetics supports similarities between exertional heat stroke and malignant hyperthermia.
Topics: Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Energy Metabolism; Halothane; Heat Stroke; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Magnetic Resonance Spectroscopy; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Phosphates; Phosphocreatine | 2001 |
Prolonging viability of swine muscle biopsy specimens in malignant hyperthermia testing.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Central Nervous System Stimulants; Cold Temperature; Electric Stimulation; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Swine; Tissue Preservation | 2001 |
Congenital myopathy with central cores and fingerprint bodies in association with malignant hyperthermia susceptibility.
Topics: Adult; Anesthetics, Inhalation; Biopsy; Caffeine; Central Nervous System Stimulants; Halothane; Humans; In Vitro Techniques; Inclusion Bodies; Male; Malignant Hyperthermia; Microscopy, Electron; Muscle Contraction; Muscle Fibers, Skeletal; Myopathy, Central Core; Nuclear Family | 2001 |
Determination of a positive malignant hyperthermia (MH) disposition without the in vitro contracture test in families carrying the RYR1 Arg614Cys mutation.
Topics: Caffeine; DNA; DNA Mutational Analysis; Family Health; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Mutation, Missense; Pedigree; Phenotype; Ryanodine Receptor Calcium Release Channel | 2001 |
Testing for malignant hyperthermia.
Topics: Anesthesia; Biopsy; Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Sensitivity and Specificity | 2002 |
Mutation screening in the ryanodine receptor 1 gene (RYR1) in patients susceptible to malignant hyperthermia who show definite IVCT results: identification of three novel mutations.
Topics: Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Genetic Testing; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscles; Mutation; Ryanodine Receptor Calcium Release Channel | 2002 |
RYR1 mutations causing central core disease are associated with more severe malignant hyperthermia in vitro contracture test phenotypes.
Topics: Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Exons; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle, Skeletal; Mutation; Myopathy, Central Core; Phenotype; Prevalence; Retrospective Studies; Ryanodine; Ryanodine Receptor Calcium Release Channel; United Kingdom | 2002 |
Results of contracture tests with halothane, caffeine, and ryanodine depend on different malignant hyperthermia-associated ryanodine receptor gene mutations.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Child; Child, Preschool; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Mutation; Prospective Studies; Ryanodine Receptor Calcium Release Channel | 2002 |
Reproducibility of in vitro contracture test results in patients tested for malignant hyperthermia susceptibility.
Topics: Adult; Anesthetics, Inhalation; Biopsy; Caffeine; Disease Susceptibility; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity | 2002 |
"Noninvasive" testing for malignant hyperthermia susceptibility.
Topics: Caffeine; Calcium; Cresols; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction | 2002 |
Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes.
Topics: Adolescent; Adult; B-Lymphocytes; Caffeine; Calcium; Child; Cresols; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Mutation; Ryanodine Receptor Calcium Release Channel | 2002 |
Inhibitory effect of caffeine on C-fibre-evoked excitation in the rat spinal dorsal horn recorded under Ca2+-free condition: an interaction with halothane.
Topics: Action Potentials; Afferent Pathways; Analysis of Variance; Anesthetics, Inhalation; Animals; Caffeine; Calcium; Calcium Signaling; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Halothane; In Vitro Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 2003 |
Extending the skeletal muscle viability period in the malignant hyperthermia test.
Topics: Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Electric Stimulation; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Temperature | 2003 |
Detection of a novel ryanodine receptor subtype 1 mutation (R328W) in a malignant hyperthermia family by sequencing of a leukocyte transcript.
Topics: Amino Acid Substitution; Anesthetics, Inhalation; Caffeine; Cell Line; DNA, Complementary; Halothane; Humans; Leukocytes; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Mutation; Pedigree; Phosphodiesterase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA; Ryanodine Receptor Calcium Release Channel; Transcription, Genetic | 2003 |
Mg2+ dependence of halothane-induced Ca2+ release from the sarcoplasmic reticulum in rat skeletal muscle.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium; Cytosol; Halothane; In Vitro Techniques; Magnesium; Muscle, Skeletal; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2003 |
Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.
Topics: Adult; Aged; Caffeine; Calcium; Child; Child, Preschool; Cresols; Female; Genetic Predisposition to Disease; Halothane; Heterozygote; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle Fibers, Skeletal; Point Mutation; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2003 |
A new mutation in the skeletal ryanodine receptor gene (RYR1) is potentially causative of malignant hyperthermia, central core disease, and severe skeletal malformation.
Topics: Adolescent; Base Sequence; Caffeine; DNA; DNA Mutational Analysis; Dysostoses; Family Health; Female; Genotype; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Musculoskeletal Abnormalities; Mutation; Myopathy, Central Core; Pedigree; Phenotype; Point Mutation; Ryanodine Receptor Calcium Release Channel | 2004 |
Genetic testing for malignant hyperthermia in North America.
Topics: Anesthetics, Inhalation; Caffeine; Genetic Testing; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; North America; Ryanodine Receptor Calcium Release Channel | 2004 |
Similar susceptibility to halothane, caffeine and ryanodine in vitro reflects pharmacogenetic variability of malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Biopsy; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Female; Genetic Predisposition to Disease; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle, Skeletal; Retrospective Studies; Ryanodine; Time Factors | 2004 |
[Delayed onset of malignant hyperthermia crisis during a living donor liver transplantation caused by sevoflurane].
Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Gas Analysis; Caffeine; Central Nervous System Stimulants; Halothane; Humans; Liver Transplantation; Living Donors; Male; Malignant Hyperthermia; Methyl Ethers; Sevoflurane | 2004 |
Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model.
Topics: Adolescent; Adult; Aged; Anesthetics; Biopsy; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimulants; Child; Child, Preschool; Cresols; Dose-Response Relationship, Drug; Exons; Family Health; Fungicides, Industrial; Fura-2; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Molecular Biology; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; Ryanodine Receptor Calcium Release Channel | 2004 |
Comparative analysis of in vitro contracture tests with ryanodine and a combination of ryanodine with either halothane or caffeine: a comparative investigation in malignant hyperthermia.
Topics: Anesthetics, Inhalation; Caffeine; DNA; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Mutation; Phosphodiesterase Inhibitors; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; ROC Curve; Ryanodine | 2004 |
Mg2+ dependence of halothane-induced Ca2+ release from the sarcoplasmic reticulum in skeletal muscle from humans susceptible to malignant hyperthermia.
Topics: Anesthetics, Inhalation; Caffeine; Calcium; Central Nervous System Stimulants; Cytosol; Halothane; Humans; In Vitro Techniques; Magnesium; Malignant Hyperthermia; Muscle Fibers, Skeletal; Muscle, Skeletal; Ryanodine; Sarcoplasmic Reticulum | 2004 |
Malignant hyperthermia: update on susceptibility testing.
Topics: Algorithms; B-Lymphocytes; Biopsy; Caffeine; Disease Susceptibility; DNA Mutational Analysis; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Musculoskeletal Diseases; Ryanodine Receptor Calcium Release Channel | 2005 |
Inheritance of recurrent exertional rhabdomyolysis in thoroughbreds.
Topics: Anesthetics, Inhalation; Animals; Biopsy; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Female; Genes, Dominant; Halothane; Horse Diseases; Horses; Male; Muscle Contraction; Muscle, Skeletal; Pedigree; Physical Conditioning, Animal; Recurrence; Rhabdomyolysis | 2005 |
Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis.
Topics: Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Caffeine; Central Nervous System Stimulants; Creatine Kinase; Cresols; Dose-Response Relationship, Drug; Electrolytes; Glucose; Halothane; Ketamine; Lactic Acid; Malignant Hyperthermia; Microdialysis; Muscle, Skeletal; Propofol; Pyruvic Acid; Ryanodine Receptor Calcium Release Channel; Swine | 2006 |
The dose-response relationship and regional distribution of lactate after intramuscular injection of halothane and caffeine in malignant hyperthermia-susceptible pigs.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Carbon Dioxide; Disease Susceptibility; Dose-Response Relationship, Drug; Halothane; Injections, Intramuscular; Lactic Acid; Malignant Hyperthermia; Microdialysis; Swine | 2006 |
Validity and new malignant hyperthermia diagnostic procedures.
Topics: Caffeine; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Reproducibility of Results; Ryanodine | 2006 |
Pharmacologic modulation of skeletal muscle metabolism: a microdialysis study.
Topics: Animals; Caffeine; Calcium; Dantrolene; Halothane; In Vitro Techniques; Lactic Acid; Male; Microdialysis; Muscle, Skeletal; Rats; Rats, Sprague-Dawley | 2006 |
Malignant hyperthermia in China.
Topics: Anesthesia, General; Caffeine; China; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction | 2006 |
Male preponderance of patients testing positive for malignant hyperthermia susceptibility.
Topics: Caffeine; Family; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Mutation; Registries; Research Design; Sex Factors; Statistics, Nonparametric; Sweden | 2007 |
Effects of ryanodine on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis.
Topics: Animals; Caffeine; Disease Susceptibility; Halothane; Kinetics; Lactates; Malignant Hyperthermia; Microdialysis; Muscle, Skeletal; Pyruvates; Reference Values; Ryanodine; Ryanodine Receptor Calcium Release Channel; Swine; Swine Diseases | 2008 |
Fulminant malignant hyperthermia.
Topics: Adult; Anesthetics, General; Caffeine; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Neuromuscular Nondepolarizing Agents; Oral Surgical Procedures; Pedigree; Vecuronium Bromide | 2008 |
[Application of caffeine-halothane contracture test in the diagnosis of malignant hyperthermia].
Topics: Anesthetics, Inhalation; Caffeine; Creatine Kinase; Enzyme-Linked Immunosorbent Assay; Halothane; Humans; Isoflurane; Malignant Hyperthermia; Muscle, Skeletal; Myoglobin; Ryanodine Receptor Calcium Release Channel | 2008 |
[In-vivo diagnosis of malignant hyperthermia susceptibility: a microdialysis study].
Topics: Adolescent; Adult; Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Creatine; Dialysis Solutions; Female; Halothane; Hemodynamics; Humans; Injections, Intramuscular; Lactic Acid; Male; Malignant Hyperthermia; Microdialysis; Middle Aged; Muscle, Skeletal; Myoglobin; Psychometrics; Young Adult | 2008 |
An in-vivo metabolic test for detecting malignant hyperthermia susceptibility in humans: a pilot study.
Topics: Adult; Biopsy; Caffeine; Case-Control Studies; Disease Susceptibility; Female; Halothane; Humans; Lactates; Male; Malignant Hyperthermia; Middle Aged; Muscles; Pilot Projects; Quadriceps Muscle | 2008 |
Novel ryanodine receptor mutation that may cause malignant hyperthermia.
Topics: Amino Acid Substitution; Anesthetics, Inhalation; Austria; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimulants; Child; Cresols; Dose-Response Relationship, Drug; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; Patch-Clamp Techniques; Polymerase Chain Reaction; RNA, Messenger; Ryanodine Receptor Calcium Release Channel | 2008 |
You're "hot" from pumping iron?
Topics: Anesthesia; Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Creatine; Dietary Supplements; Environment; Gene Expression; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Weight Lifting; Young Adult | 2009 |
Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice.
Topics: Anesthetics; Animals; Caffeine; Calcium; Calcium-Binding Proteins; Calsequestrin; Central Nervous System Stimulants; Dantrolene; Death, Sudden; Female; Halothane; Hot Temperature; Humans; Male; Malignant Hyperthermia; Mice; Mice, Knockout; Muscle Relaxants, Central; Muscle, Skeletal; Rhabdomyolysis; Ryanodine Receptor Calcium Release Channel; Survival Rate | 2009 |
Genetic variation in RYR1 and malignant hyperthermia phenotypes.
Topics: Anesthetics, Inhalation; Caffeine; Creatine Kinase; DNA Mutational Analysis; DNA, Complementary; Female; Genetic Predisposition to Disease; Genotype; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Mutation; Phenotype; Phosphodiesterase Inhibitors; Ryanodine Receptor Calcium Release Channel; Tissue Culture Techniques | 2009 |
Malignant hyperthermia susceptibility in a patient with mitochondrial disorder.
Topics: Abnormalities, Multiple; Aged; Anesthesia; Anesthetics, Inhalation; Caffeine; Halothane; Humans; Male; Malignant Hyperthermia; Mitochondrial Diseases; Muscle, Skeletal; Phosphodiesterase Inhibitors | 2009 |
Intramuscular injection of malignant hyperthermia trigger agents induces hypermetabolism in susceptible and nonsusceptible individuals.
Topics: Adolescent; Adult; Aged; Caffeine; Carbon Dioxide; Female; Halothane; Humans; Injections, Intramuscular; Lactates; Male; Malignant Hyperthermia; Middle Aged; Muscle, Skeletal; Oxygen; Soybean Oil | 2010 |
The role of CACNA1S in predisposition to malignant hyperthermia.
Topics: Adolescent; Adult; Aged; Amino Acid Sequence; Caffeine; Calcium Channels; Calcium Channels, L-Type; Child; Cohort Studies; Female; Genetic Predisposition to Disease; Halothane; Haplotypes; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Middle Aged; Muscle Contraction; Muscle, Skeletal; Mutation; Polymorphism, Single Nucleotide; Young Adult | 2009 |
Multigenerational Brazilian family with malignant hyperthermia and a novel mutation in the RYR1 gene.
Topics: Brazil; Caffeine; Contracture; Family; Female; Genetic Testing; Halothane; Humans; Male; Malignant Hyperthermia; Mutation, Missense; Pedigree; Ryanodine Receptor Calcium Release Channel | 2009 |
Contractile properties of esophageal striated muscle: comparison with cardiac and skeletal muscles in rats.
Topics: Animals; Caffeine; Electric Stimulation; Esophagus; Gap Junctions; Halothane; In Vitro Techniques; Male; Muscle Contraction; Muscle, Skeletal; Myocardium; Potassium; Rats; Rats, Wistar | 2010 |
Use of the caffeine-halothane contracture test for the diagnosis of malignant hyperthermia in Brazil.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Biopsy; Caffeine; Child; Child, Preschool; Contracture; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Sensitivity and Specificity; Severity of Illness Index; Young Adult | 2010 |
Clinical features and diagnosis for Chinese cases with malignant hyperthermia: a case cluster from 2005 to 2007.
Topics: Adolescent; Adult; Caffeine; Child; China; Female; Halothane; Humans; In Vitro Techniques; Male; Malignant Hyperthermia; Muscle Contraction; Young Adult | 2010 |
Analysis of human cultured myotubes responses mediated by ryanodine receptor 1.
Topics: Adolescent; Adult; Aged; Caffeine; Calcium; Cells, Cultured; Child; Child, Preschool; Cresols; Dose-Response Relationship, Drug; Female; Genetic Predisposition to Disease; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Muscle Fibers, Skeletal; ROC Curve; Ryanodine Receptor Calcium Release Channel; Young Adult | 2011 |
Sevoflurane as a potential replacement for halothane in diagnostic testing for malignant hyperthermia susceptibility: results of a preliminary study.
Topics: Anesthetics, Inhalation; Caffeine; Central Nervous System Stimulants; Disease Susceptibility; Dose-Response Relationship, Drug; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Methyl Ethers; Muscle Contraction; Respiratory Muscles; Sevoflurane | 2011 |
Novel double and single ryanodine receptor 1 variants in two Austrian malignant hyperthermia families.
Topics: Amino Acid Substitution; Anesthesia, General; Anesthetics, Inhalation; Caffeine; Calcium; Cells, Cultured; Central Nervous System Stimulants; Child; Cytoplasm; DNA, Complementary; Dose-Response Relationship, Drug; Genetic Variation; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Fibers, Skeletal; Muscle, Skeletal; Pedigree; Polymerase Chain Reaction; Ryanodine Receptor Calcium Release Channel; Tonsillectomy | 2012 |
3,5-Di-t-butyl catechol is a potent human ryanodine receptor 1 activator, not suitable for the diagnosis of malignant hyperthermia susceptibility.
Topics: Caffeine; Calcium; Calcium Channel Agonists; Catechols; Cells, Cultured; Dose-Response Relationship, Drug; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscle Fibers, Skeletal; Predictive Value of Tests; Risk Assessment; Risk Factors; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Time Factors | 2012 |
Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene.
Topics: Anesthetics, Inhalation; Antipsychotic Agents; Body Temperature; Caffeine; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Creatine Kinase; Dantrolene; Disseminated Intravascular Coagulation; Female; Genetic Variation; Hallucinogens; Haloperidol; Halothane; Humans; Multiple Organ Failure; N-Methyl-3,4-methylenedioxyamphetamine; Neuroleptic Malignant Syndrome; Recurrence; Rhabdomyolysis; Ryanodine Receptor Calcium Release Channel; Spectrum Analysis; Young Adult | 2012 |
A family with discordance between malignant hyperthermia susceptibility and rippling muscle disease.
Topics: Anesthesia; Anesthesia, General; Anesthetics, Inhalation; Caffeine; Caveolin 3; Creatine Kinase; Family; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscular Diseases; Mutation; Pedigree; Phenotype; Phosphodiesterase Inhibitors; Treatment Outcome | 2013 |
In vitro muscle contracture investigations on the malignant hyperthermia like episodes in myotonia congenita.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Malignant Hyperthermia; Membrane Potentials; Mice; Mice, Neurologic Mutants; Muscle Contraction; Muscle, Skeletal; Myotonia Congenita; Ryanodine Receptor Calcium Release Channel | 2013 |
Malignant hyperthermia in Canada: characteristics of index anesthetics in 129 malignant hyperthermia susceptible probands.
Topics: Adolescent; Adult; Aged; Anesthetics; Caffeine; Canada; Child; Child, Preschool; Dantrolene; Female; Fever; Halothane; Humans; Hypercapnia; Incidence; Infant; Male; Malignant Hyperthermia; Middle Aged; Mutation; Registries; Retrospective Studies; Ryanodine Receptor Calcium Release Channel; Succinylcholine; Tachycardia; Young Adult | 2014 |
Analysis of histomorphology in malignant hyperthermia-susceptible patients.
Topics: Adult; Caffeine; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Mutation; Phenotype; Retrospective Studies | 2013 |
Contractile elements in muscular fascial tissue - implications for in-vitro contracture testing for malignant hyperthermia.
Topics: Anesthesia, General; Anesthetics, General; Animals; Biopsy; Caffeine; Central Nervous System Stimulants; Electric Stimulation; Facial Muscles; Fluorescent Antibody Technique; Halothane; Histamine H1 Antagonists; Immunohistochemistry; In Vitro Techniques; Malignant Hyperthermia; Mice; Mice, Inbred BALB C; Muscle Contraction; Pyrilamine; Rats; Rats, Wistar | 2014 |
Malignant hyperthermia testing in probands without adverse anesthetic reaction.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Dantrolene; Drug-Related Side Effects and Adverse Reactions; Female; Halothane; Humans; Male; Malignant Hyperthermia; Middle Aged; Retrospective Studies; Young Adult | 2015 |
Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia?
Topics: Adult; Anesthetics, Inhalation; Caffeine; Contracture; Disease Susceptibility; Female; Halothane; Heat Stroke; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Retrospective Studies; Risk Factors | 2015 |
Cystathionine β-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.
Topics: Biopsy; Caffeine; Case-Control Studies; Cystathionine beta-Synthase; Dose-Response Relationship, Drug; Gasotransmitters; Gene Expression Regulation, Enzymologic; Glyburide; Halothane; Humans; Hydrogen Sulfide; In Vitro Techniques; KATP Channels; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Potassium Channel Blockers; RNA, Messenger; Signal Transduction; Sulfides; Up-Regulation | 2016 |
Functional characterization of the RYR1 mutation p.Arg4737Trp associated with susceptibility to malignant hyperthermia.
Topics: Anesthetics; Arginine; B-Lymphocytes; Caffeine; Cell Line, Transformed; Cresols; Family Health; Female; Fungicides, Industrial; Genetic Predisposition to Disease; Germany; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Phosphodiesterase Inhibitors; Polymorphism, Single Nucleotide; Ryanodine Receptor Calcium Release Channel; Tryptophan | 2016 |
Skeletal Muscle Metabolic Dysfunction in Patients With Malignant Hyperthermia Susceptibility.
Topics: Adult; Anesthetics; Anthropometry; Caffeine; Case-Control Studies; Disease Susceptibility; Exercise Test; Female; Halothane; Humans; Magnetic Resonance Imaging; Male; Malignant Hyperthermia; Metabolic Diseases; Middle Aged; Muscle Contraction; Muscle, Skeletal; Muscular Diseases; Oxygen; Surveys and Questionnaires | 2017 |
Microdialysis and ultrasound elastography for monitoring of localized muscular reaction after pharmacological stimulation in rats.
Topics: Animals; Caffeine; Elasticity Imaging Techniques; Halothane; Malignant Hyperthermia; Microdialysis; Muscle Contraction; Muscle, Skeletal; Rats | 2018 |
Ultrasound Elastography for Rapid, Real-time Detection of Localized Muscular Reaction in Malignant Hyperthermia-susceptible Pigs.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Elasticity Imaging Techniques; Halothane; Malignant Hyperthermia; Muscle Contraction; Muscle, Skeletal; Pilot Projects; Swine | 2018 |
Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1.
Topics: Anesthetics, Inhalation; Animals; Caffeine; Calcium; Calcium Signaling; Dose-Response Relationship, Drug; Gene Knock-In Techniques; Halothane; Heat Stress Disorders; Male; Malignant Hyperthermia; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle, Skeletal; Mutation; Phenotype; Potassium Chloride; Ryanodine Receptor Calcium Release Channel | 2018 |
Abnormal calcium signalling and the caffeine-halothane contracture test.
Topics: Adult; Anesthetics, Inhalation; Caffeine; Calcium; Cells, Cultured; Disease Susceptibility; Dose-Response Relationship, Drug; Female; Halothane; Humans; Male; Malignant Hyperthermia; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Signal Transduction | 2019 |
Understanding malignant hyperthermia: each move forward opens our eyes to the distance left to travel.
Topics: Caffeine; Calcium; Contracture; Halothane; Humans; Malignant Hyperthermia | 2019 |
A multi-dimensional analysis of genotype-phenotype discordance in malignant hyperthermia susceptibility.
Topics: Adult; Anesthetics, Inhalation; Caffeine; Female; Genotype; Halothane; Humans; Malignant Hyperthermia; Mutation; Phenotype; Reproducibility of Results; Ryanodine Receptor Calcium Release Channel | 2020 |
Malignant Hyperthermia: A Killer If Ignored.
Topics: Adolescent; Caffeine; China; Halothane; Humans; Malignant Hyperthermia; Mutation | 2022 |
Management of patients susceptible to malignant hyperthermia: A surgeon's perspective.
Topics: Caffeine; Child; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Retrospective Studies; Surgeons | 2022 |
Distinct pathophysiological characteristics in developing muscle from patients susceptible to malignant hyperthermia.
Topics: Caffeine; Calcium; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Muscle Contraction; Muscle Fibers, Skeletal | 2023 |
What is malignant hyperthermia susceptibility?
Topics: Anesthesia; Biopsy; Caffeine; Halothane; Humans; Malignant Hyperthermia | 2023 |