haloperidol and u-50488

Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Binding Sites; Brain; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Piperazines; Pyrrolidines; Rabbits; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship

Topics: Cross-Linking Reagents; Molecular Structure; Piperazine; Piperazines; Receptors, sigma

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship

Topics: Animals; Azabicyclo Compounds; Cell Line; Guinea Pigs; Humans; In Vitro Techniques; Molecular Conformation; Radioligand Assay; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship

Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship

Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship

Topics: Analgesics, Opioid; Animals; Binding, Competitive; Blood-Brain Barrier; Brain; Endothelial Cells; Guinea Pigs; HEK293 Cells; Humans; Liver; Male; Mice; Models, Molecular; Pain Measurement; Permeability; Pyrrolidines; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship

Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine

Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship

Topics: Animals; Guinea Pigs; Hydrogen; Hydrogen Sulfide; Ligands; Male; Morpholines; Pain; Piperazines; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor

Topics: Molecular Conformation; Pyrrolidines; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship

Topics: Haloperidol; Ligands; Piperidines; Quinolines; Receptors, sigma; Structure-Activity Relationship

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 3,4-Dihydroxyphenylacetic Acid; Analgesics; Animals; Dialysis; Dopamine; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraventricular; Male; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Wistar

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Cortex; Electroencephalography; Haloperidol; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Autoradiography; Behavior, Animal; Binding Sites; Female; Guinea Pigs; Haloperidol; Hippocampus; Male; Pyrrolidines; Sodium Chloride; Time Factors

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Drug Synergism; Haloperidol; Morphine; Naloxone; Narcotics; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sulpiride

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamine; Animals; Appetite Depressants; Central Nervous System Stimulants; Diuresis; Dizocilpine Maleate; Dopamine; Drinking; Drug Synergism; Eating; Endorphins; Haloperidol; Male; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Urodynamics

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Coronary Vessels; Fentanyl; Haloperidol; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Pyrrolidines; Receptors, Opioid; Swine

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Haloperidol; Male; Mice; Morphine; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, sigma; Species Specificity

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Brain; Brain Stem; Cerebral Cortex; Corpus Striatum; Dopamine; Haloperidol; Levodopa; Male; Methamphetamine; Mice; Morphine; Motor Activity; Pyrrolidines

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Apomorphine; Dopamine Agents; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Haloperidol; Ileum; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Pyrrolidines; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Benzamides; Binding, Competitive; Brain; Cattle; Cerebellum; Cerebral Cortex; Corpus Striatum; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Guanidines; Haloperidol; In Vitro Techniques; Isotope Labeling; Narcotic Antagonists; Pentazocine; Piperidines; Propylamines; Pyrrolidines; Receptors, Dopamine D2; Receptors, sigma; Sulpiride; Tritium

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Autoradiography; Baclofen; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Haloperidol; Immunohistochemistry; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Propranolol; Receptors, Opioid; Somatostatin; Spinal Cord; Sulfur Radioisotopes; Yohimbine

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Haloperidol; Male; Methamphetamine; Mice; Morphine; Motor Activity

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Inhibition, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa; Reflex, Startle