haloperidol has been researched along with prazosin in 111 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (29.73) | 18.7374 |
| 1990's | 37 (33.33) | 18.2507 |
| 2000's | 19 (17.12) | 29.6817 |
| 2010's | 21 (18.92) | 24.3611 |
| 2020's | 1 (0.90) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Audinot, V; Bervoets, K; Brocco, M; Canton, H; Gobert, A; Le Marouille-Girardon, S; Millan, MJ; Peglion, JL | 1 |
| Berardi, F; Colabufo, NA; Fiorentini, F; Ghiglieri, A; Govoni, S; Leopoldo, M; Olgiati, V; Perrone, R; Tortorella, V | 1 |
| Berardi, F; Caccia, C; Fornaretto, MG; Leopoldo, M; McArthur, RA; Perrone, R; Tortorella, V | 1 |
| Berardi, F; Caccia, C; Colabufo, NA; Fornaretto, MG; Leopoldo, M; McArthur, RA; Perrone, R; Tortorella, V | 1 |
| Brasili, L; Di Toro, R; Giannella, M; Melchiorre, C; Piergentili, A; Pigini, M; Quaglia, W; Rossetti, L; Spampinato, S | 1 |
| Kimura, T; Kontani, T; Mase, T; Naito, R; Nomura, T; Tsukamoto, S; Wanibuchi, F; Yamaguchi, T; Yamashita, H; Yasunaga, T | 1 |
| Akunne, HC; Belliotti, TR; Brink, WA; Corbin, AE; Georgic, LM; Heffner, TG; Pugsley, TA; Shih, YH; Whetzel, SZ; Wise, LD; Wustrow, DJ; Zoski, KT | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Beroza, P; Bradley, EK; Grootenhuis, PD; Miller, JL; Penzotti, JE; Spellmeyer, DC | 1 |
| Andersen, K; Balle, T; Larsen, AK; Liljefors, T; Perregaard, J; Ramirez, MT; Søby, KK | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Bariwal, JB; Chauhan, BS; Jain, KS; Kathiravan, MK; Phoujdar, MS; Sahne, RS; Shah, AK; Yadav, MR | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Ang, KK; Arkin, MR; Chen, S; Doyle, PS; Engel, JC; McKerrow, JH | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Bandyopadhyaya, A; Rajagopalan, DR; Rajagopalan, P; Rajagopalan, R | 1 |
| Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Chelly, J; Huchet, AM; Mouillé, P; Schmitt, H | 1 |
| Maj, J; Rogóz, Z; Skuza, G; Sowińska, H | 1 |
| Barker, EL; Burris, KD; Sanders-Bush, E | 1 |
| Nurminen, ML; Paakkari, I | 1 |
| Borowsky, B; Kuhn, CM | 1 |
| Ewing, FE; Furman, JS; Heym, JH; Howard, HR; Lowe, JA; Nagel, AA; Newman, ME; Schmidt, AW; Seeger, TF; Seymour, PA | 1 |
| Guenaneche, F; Lefebvre, RA; Schuurkes, JA | 1 |
| Li, BH; Li, Q | 1 |
| Maj, J; Rogóz, Z; Skuza, G | 1 |
| Backus, LI; Grahame-Smith, DG; Sharp, T | 1 |
| Defaux, JP; Junien, JL; Pascaud, X; Rozé, C | 1 |
| Boulat, O; Maitre, L; Waldmeier, P | 1 |
| Burki, HR | 1 |
| Broekkamp, CL; Jenck, F; Van Delft, AM | 1 |
| Broadley, KJ; Williamson, KL | 1 |
| Cichini, G; Kraupp, O; Singer, EA; Valenta, B | 1 |
| Cardinali, DP; Chuluyan, HE; Rosenstein, RE | 1 |
| Fujiwara, Y; Kazahaya, Y; Otsuki, S; Sandyk, R; Takeda, T | 1 |
| Blaha, CD; Lane, RF; Rivet, JM | 1 |
| Lewis, RA; Vonvoigtlander, PF | 1 |
| Ferrari, F | 1 |
| Bunney, BS; Chiodo, LA | 1 |
| Chihara, K; Fujita, T; Kaji, H; Kita, T; Kodama, H; Minamitani, N | 1 |
| Baggio, G; Ferrari, F; Martinelli, R | 1 |
| Gebhart, GF; Ossipov, MH | 1 |
| Andorn, AC | 1 |
| Cohen, BM; Lipinski, JF | 1 |
| Bradshaw, CM; Sheridan, RD; Szabadi, E | 1 |
| Forler, C; Fozard, JR; Middlemiss, DN; Tricklebank, MD | 1 |
| De Robertis, E; De Stein, ML; Medina, JH; Pazo, JH; Tumilasci, OR | 1 |
| Baran, H; Hornykiewicz, O; Hörtnagl, H; Sapetschnig, G; Sperk, G | 1 |
| Böhmer, G; Gouzoulis, E; Löffelholz, K; Raach, M; Schmid, K | 1 |
| Engel, JA; Goldstein, M; Johannessen, K; Liljequist, S | 1 |
| Fowler, CJ; Thorell, G | 1 |
| Herr, DW; Tilson, HA | 1 |
| Clark, D; Elam, M; Svensson, TH | 1 |
| Costall, B; Eniojukan, JF; Naylor, RJ | 1 |
| Russell, RD; Stripling, JS | 1 |
| Hall, N; Liebman, JM; Prowse, J | 1 |
| Bischoff, S; Ortmann, R; Waldmeier, PC | 1 |
| Borsini, F; Nowakowska, E; Samanin, R | 1 |
| Fenton, HM; Liebman, JM | 1 |
| Deutch, AY; Duman, RS; Ongür, D | 1 |
| Arnt, J | 1 |
| Chen, YH; Tsai, MC | 1 |
| Gupta, SK; Husain, M; Tangri, KK; Vrat, S | 1 |
| Andersson, JL; Marcus, M; Nomikos, GG; Svensson, TH | 1 |
| Kulkarni, SK; Sharma, A | 1 |
| Hirobe, M; Nagao, T; Ohta, S; Ono, H; Tateyama, M | 1 |
| Batrak, GN; Degtiar, VY; Hawryluk, BR; Luik, AI; Mogilevich, SE; Naydyenova, IY; Prokopenko, RA | 1 |
| Chopde, CT; Hote, MS; Mandhane, SN; Muthal, AV | 1 |
| Obuchowicz, E | 2 |
| Chang, TK; Cheng, JT; Niu, CS | 1 |
| Kleven, MS; Koek, W; Prinssen, EP | 1 |
| Duman, RS; Morinobu, S; Strausbaugh, H; Terwilliger, R | 1 |
| Costela, C; Gibert-Rahola, J; Tejedor-Real, P | 1 |
| Gioanni, Y; Glowinski, J; Tassin, JP; Thierry, AM | 1 |
| Depoortere, R; Perrault, G; Sanger, DJ | 1 |
| Fox, K; Lam, P; Ling, V; Shapiro, AB | 1 |
| Chen, YH; Chuang, YC; Huang, SS; Tsai, MC | 1 |
| Lai, WS; Liao, RM; Lin, JY | 1 |
| Cahir, M; King, DJ; Mawhinney, T | 1 |
| Akimoto, Y; Horinouchi, T; Koike, K; Tanaka, Y | 1 |
| Hashimoto, K; Hattori, K; Iyo, M; Yanahashi, S; Yuasa, S | 1 |
| Kristensen, T; Mulvany, MJ; Nielsen, KB; Nourian, Z; Pickering, DS | 1 |
| Bagosi, Z; Jászberényi, M; Palotai, M; Tanaka, M; Telegdy, G | 1 |
2 review(s) available for haloperidol and prazosin
| Article | Year |
|---|---|
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Humans; Hypertension; Molecular Structure; Receptors, Adrenergic, alpha-1; Risk Factors; Stereoisomerism; Structure-Activity Relationship | 2008 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
109 other study(ies) available for haloperidol and prazosin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Male; Piperazines; Rats; Rats, Wistar; Serotonin Antagonists; Structure-Activity Relationship | 1995 |
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Guinea Pigs; Isomerism; Kinetics; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1995 |
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
Topics: Animals; Buspirone; Mass Spectrometry; Molecular Structure; Piperazines; Protein Binding; Rats; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists | 1996 |
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.
Topics: Magnetic Resonance Spectroscopy; Piperazines; Radioligand Assay; Receptors, Serotonin; Structure-Activity Relationship | 1996 |
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.
Topics: Animals; Guinea Pigs; Ligands; Piperidines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Opioid; Receptors, Serotonin; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Structure-Activity Relationship | 1998 |
Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Behavior, Animal; CHO Cells; Chromones; Colforsin; Cricetinae; Dioxoles; Drug Evaluation, Preclinical; Electrophysiology; Humans; In Vitro Techniques; Male; Neurons; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship | 1998 |
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; CHO Cells; Corpus Striatum; Cricetinae; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Hippocampus; Magnetic Resonance Spectroscopy; Oxazines; Rats; Receptors, Dopamine D4 | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
A rapid computational method for lead evolution: description and application to alpha(1)-adrenergic antagonists.
Topics: Adrenergic alpha-Antagonists; Databases, Factual; Drug Design; Glycine; Heterocyclic Compounds; Ligands; Models, Molecular; Molecular Conformation; Receptors, Adrenergic, alpha-1 | 2000 |
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Azoles; Brain; Cell Line; Cricetinae; Humans; Imidazoles; In Vitro Techniques; Indoles; Pyridines; Pyrimidines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship; Triazoles | 2003 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
Topics: Animals; Cattle; Cell Line; Cell Line, Tumor; Chagas Disease; Drug Evaluation, Preclinical; Hepatocytes; High-Throughput Screening Assays; Humans; Image Processing, Computer-Assisted; Muscle, Skeletal; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma cruzi | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Topics: Benzodiazepinones; Isomerism; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface | 2014 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
[Action of N-butylnorsympathone on the effects of cardioaccelerator nerve stimulation in the dog].
Topics: Animals; Blood Pressure; Dogs; Electric Stimulation; Ethanolamines; Female; Haloperidol; Heart Conduction System; Heart Rate; Male; Phentolamine; Prazosin; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Neurotransmitter; Secologanin Tryptamine Alkaloids | 1979 |
Effects of MK-801 and antidepressant drugs in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents; Citalopram; Depression; Dizocilpine Maleate; Haloperidol; Imipramine; Male; Mianserin; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Swimming | 1992 |
Phosphoinositide hydrolysis linked 5-HT2 receptors in fibroblasts from choroid plexus.
Topics: Animals; Cells, Cultured; Choroid Plexus; DOM 2,5-Dimethoxy-4-Methylamphetamine; Fibroblasts; Haloperidol; Hydrolysis; Inositol Phosphates; Ketanserin; Lysergic Acid Diethylamide; Male; Mianserin; Phosphatidylinositols; Prazosin; Rabbits; Receptors, Serotonin; Serotonin; Spiperone | 1991 |
Role of peripheral and central catecholaminergic and cholinergic mechanisms in the cardiovascular effects of thyrotropin-releasing hormone.
Topics: Animals; Atenolol; Atropine Derivatives; Blood Pressure; Brain; Butoxamine; Cerebral Ventricles; Fenclonine; Haloperidol; Heart Rate; Injections, Intraperitoneal; Injections, Intraventricular; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Thyrotropin-Releasing Hormone; Reserpine; Thyrotropin-Releasing Hormone; Vagotomy; Yohimbine | 1991 |
Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation.
Topics: Adrenocorticotropic Hormone; Animals; Biogenic Monoamines; Cocaine; Corticosterone; Dopamine; Dopamine Antagonists; Haloperidol; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Ketanserin; Male; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Piperazines; Pituitary-Adrenal System; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stimulation, Chemical; Time Factors | 1991 |
1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Behavior, Animal; Dopamine Antagonists; Haloperidol; Ketanserin; Locomotion; Male; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
Influence of fenoldopam and quinpirole in the guinea-pig stomach.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clonidine; Dopamine; Dopamine Agents; Electric Stimulation; Ergolines; Female; Fenoldopam; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Methysergide; Muscle Contraction; Muscle Relaxation; Prazosin; Quinpirole; Stomach; Yohimbine | 1991 |
[Comparison of central stimulating effects between ephedrine and apomorphine].
Topics: Animals; Apomorphine; Blepharoptosis; Catalepsy; Ephedrine; Haloperidol; Male; Mice; Motor Activity; Prazosin; Rats; Rats, Inbred Strains; Stereotyped Behavior; Sulpiride; Vomiting | 1991 |
Antidepressant drugs increase the locomotor hyperactivity induced by MK-801 in rats.
Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Dizocilpine Maleate; Drug Interactions; Haloperidol; Imipramine; Male; Mianserin; Motor Activity; Prazosin; Rats; Rats, Inbred Strains | 1991 |
Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Haloperidol; Ketanserin; Male; Methoxydimethyltryptamines; Piperidines; Prazosin; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Stereotyped Behavior; Tetrahydronaphthalenes | 1990 |
Effect of selective sigma ligands on duodenal alkaline secretion in the rat.
Topics: Animals; Atropine; Bicarbonates; Dose-Response Relationship, Drug; Duodenum; Guanidines; Haloperidol; Injections, Intravenous; Intestinal Mucosa; Intestinal Secretions; Male; Naloxone; Phenazocine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Yohimbine | 1990 |
3,4-Dihydroxyphenylacetic acid (DOPAC) as an index of noradrenaline turnover: effects of Hydergine and vincamine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Cerebellum; Dihydroergotoxine; Dioxanes; Dopamine; Dopamine beta-Hydroxylase; Drug Interactions; Female; Haloperidol; Hippocampus; Idazoxan; Locus Coeruleus; Norepinephrine; Prazosin; Rats; Vincamine | 1990 |
Binding of psychoactive drugs to rat brain amine receptors, measured ex vivo, and their effects on the metabolism of biogenic amines.
Topics: Animals; Biogenic Amines; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Prazosin; Psychotropic Drugs; Rats; Rats, Inbred Strains; Receptors, Drug; Spiperone | 1986 |
Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5HT1, 5HT2 and 5HT3 receptors.
Topics: Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes; Haloperidol; Male; Periaqueductal Gray; Prazosin; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists | 1989 |
Do both adrenaline and noradrenaline stimulate cardiac alpha-adrenoceptors to induce positive inotropy of rat atria?
Topics: Animals; Cocaine; Desipramine; Dibenzylchlorethamine; Epinephrine; Haloperidol; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Norepinephrine; Pindolol; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical; Timolol | 1989 |
Effects of urapidil on catecholamine turnover and release in the central nervous system of the rat.
Topics: Animals; Blood Pressure; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Dioxanes; Dopamine; Electric Stimulation; Haloperidol; Idazoxan; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Piperazines; Prazosin; Rats; Rats, Inbred Strains | 1989 |
Serotonin release mechanisms in bovine pineal gland: stimulation by norepinephrine and dopamine.
Topics: Animals; Benzazepines; Calcium; Cattle; Clonidine; Dopamine; Dopamine Antagonists; Haloperidol; Isoproterenol; Kinetics; Norepinephrine; Phentolamine; Phenylephrine; Pineal Gland; Prazosin; Propranolol; Serotonin; Sulpiride | 1989 |
Inhibitory effects of carbamazepine on clonidine-induced aggressive behavior in mice.
Topics: Adenosine; Aggression; Animals; Behavior, Animal; Caffeine; Carbamazepine; Clonidine; Haloperidol; Male; Mice; Prazosin; Receptors, Cell Surface; Yohimbine | 1988 |
Selective inhibition of mesolimbic dopamine release following chronic administration of clozapine: involvement of alpha 1-noradrenergic receptors demonstrated by in vivo voltammetry.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Limbic System; Male; Nucleus Accumbens; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reference Values; Septal Nuclei | 1988 |
Evidence for the combined involvement of serotonergic and alpha 2 adrenergic mechanisms in the analgesic activity of tazadolene succinate.
Topics: Analgesia; Analgesics; Animals; Azetidines; Azetines; Benzazepines; Dopamine Antagonists; Female; Fenclonine; Haloperidol; Male; Mice; Mice, Inbred Strains; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Reserpine; Yohimbine | 1987 |
Sexual excitement and stretching and yawning induced by B-HT 920.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Behavior, Animal; Haloperidol; Humans; Male; Penis; Prazosin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal; Stereotyped Behavior; Sulpiride; Yohimbine | 1985 |
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons.
Topics: Anesthetics; Animals; Antipsychotic Agents; Biomechanical Phenomena; Chloral Hydrate; Clozapine; Dibenzazepines; Dioxanes; Dopamine; Drug Combinations; Haloperidol; Idazoxan; Male; Mesencephalon; Neurons; Prazosin; Rats; Rats, Inbred Strains; Trihexyphenidyl | 1985 |
Effect of various catecholamine antagonists on prolactin secretion in conscious male rabbits.
Topics: Animals; Antipsychotic Agents; Benzamides; Catecholamines; Chlorpromazine; Consciousness; Haloperidol; Male; Metoprolol; Pimozide; Prazosin; Prolactin; Propranolol; Rabbits; Radioimmunoassay; Yohimbine | 1985 |
Imidazole has similar behavioural effects to yohimbine.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Azepines; Behavior, Animal; Body Temperature; Chickens; Clonidine; Haloperidol; Hypnotics and Sedatives; Imidazoles; Male; Penile Erection; Prazosin; Rats; Sexual Behavior, Animal; Sleep; Time Factors; Yohimbine | 1986 |
Characterization of inhibition of the spinal nociceptive tail-flick reflex in the rat from the medullary lateral reticular nucleus.
Topics: Animals; Atropine; Blood Pressure; Electric Stimulation; Glutamates; Glutamic Acid; Haloperidol; Injections, Spinal; Male; Methysergide; Microinjections; Naloxone; Nociceptors; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Reflex; Reticular Formation; Spinal Cord; Yohimbine | 1986 |
Do antipsychotic drugs and serotonin down regulate [3H]-spiroperidol binding sites in human cortex?
Topics: Adolescent; Adult; Antipsychotic Agents; Binding Sites; Butyrophenones; Cerebral Cortex; Chlorpromazine; Haloperidol; Humans; Kinetics; Middle Aged; Prazosin; Serotonin; Spiperone | 1986 |
In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: implications for drug mechanisms of action.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; Clozapine; Fluphenazine; Haloperidol; Kinetics; Male; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Thioridazine | 1986 |
Excitatory neuronal responses to dopamine in the cerebral cortex: involvement of D2 but not D1 dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Appetite Depressants; Benzazepines; Cerebral Cortex; Dopamine; Ergolines; Haloperidol; In Vitro Techniques; Male; Neurons; Phenylephrine; Prazosin; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1985 |
Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Betaxolol; Haloperidol; Ketanserin; Male; Pindolol; Piperidines; Prazosin; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reserpine; Spiperone | 1985 |
Chronic haloperidol causes increase in salivary response and alpha 1-adrenoceptors in submandibular gland of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Haloperidol; Male; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Salivation; Submandibular Gland | 1985 |
Alpha 2-adrenoceptors modulate kainic acid-induced limbic seizures.
Topics: Animals; Brain Chemistry; Clonidine; Diazepam; Haloperidol; Kainic Acid; Male; Metergoline; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Seizures | 1985 |
Dopaminergic control of respiration as shown by effects of 4-aminopyridine.
Topics: 4-Aminopyridine; Aminopyridines; Anesthesia; Animals; Atropine; Domperidone; Dopamine; Haloperidol; Hemodynamics; Neuromuscular Depolarizing Agents; Phrenic Nerve; Prazosin; Rabbits; Respiration; Salivation; Vagotomy | 1986 |
Activation of alpha 2-adrenoreceptors enhances haloperidol-induced suppression of operant behavior.
Topics: Animals; Behavior, Animal; Brain Chemistry; Clonidine; Conditioning, Operant; Dihydroxyphenylalanine; Dioxanes; Drug Interactions; Haloperidol; Idazoxan; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1986 |
Antagonist effects of the enantiomers of 3-PPP towards alpha 1-adrenoceptors coupled to inositol phospholipid breakdown in the rat cerebral cortex.
Topics: Animals; Antiparkinson Agents; Atropine; Carbachol; Cerebral Cortex; Haloperidol; In Vitro Techniques; Inositol Phosphates; Male; Norepinephrine; Phenoxybenzamine; Piperidines; Prazosin; Raclopride; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Salicylamides; Stereoisomerism; Sugar Phosphates | 1987 |
Modulation of p,p'-DDT-induced tremor by catecholaminergic agents.
Topics: Animals; Apomorphine; Clonidine; DDT; Dopamine; Haloperidol; Male; Norepinephrine; Phenoxybenzamine; Prazosin; Propranolol; Rats; Rats, Inbred F344; Tremor; Yohimbine | 1987 |
Electrophysiological effects of the enantiomers of 3-PPP on neurons in the locus coeruleus of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Injections, Intravenous; Iontophoresis; Locus Coeruleus; Male; Neurons; Piperidines; Prazosin; Rats; Rats, Inbred Strains; Stereoisomerism; Yohimbine | 1986 |
Dopamine agonist action in mesolimbic, cortical and extrapyramidal areas to modify spontaneous climbing behaviour of the mouse.
Topics: Animals; Apomorphine; Cerebral Cortex; Dopamine; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Female; Haloperidol; Limbic System; Mice; Motor Activity; Prazosin; Sulpiride; Yohimbine | 1985 |
Monoaminergic and local anesthetic components of cocaine's effects on kindled seizure expression.
Topics: Amphetamine; Anesthetics, Local; Animals; Biogenic Amines; Cocaine; Drug Interactions; Haloperidol; Kindling, Neurologic; Lidocaine; Male; Metergoline; Prazosin; Propranolol; Rats; Seizures; Yohimbine | 1985 |
Effects of various catecholamine receptor antagonists, muscle relaxation and physical hindrance on shuttlebox self-stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clozapine; Haloperidol; Male; Methocarbamol; Metoclopramide; Muscle Relaxants, Central; Prazosin; Rats; Rats, Inbred F344; Reaction Time; Receptors, Dopamine; Self Stimulation | 1982 |
Modulation of dopaminergic transmission by alpha-noradrenergic agonists and antagonists: evidence for antidopaminergic properties of some alpha antagonists.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Dopamine; Female; Haloperidol; Homovanillic Acid; Male; Prazosin; Rats; Spiperone; Synaptic Transmission; Yohimbine | 1982 |
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidine; Clozapine; Depressive Disorder; Desipramine; Dibenzazepines; Haloperidol; Humans; Male; Metoclopramide; Phentolamine; Prazosin; Propranolol; Rats; Sulpiride | 1984 |
Self-stimulation response decrement patterns differentiate clonidine, baclofen and dopamine antagonists from drugs causing performance deficit.
Topics: Animals; Baclofen; Clonidine; Conditioning, Operant; Dopamine Antagonists; Extinction, Psychological; Haloperidol; Male; Methocarbamol; Metoclopramide; Prazosin; Rats; Rats, Inbred F344; Receptors, Dopamine; Self Stimulation | 1982 |
Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Clozapine; Haloperidol; Immunohistochemistry; Male; Muscarinic Antagonists; Prazosin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Ritanserin; Scopolamine; Serotonin Antagonists; Sulpiride; Thalamic Nuclei | 1995 |
Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imidazoles; Indoles; Locomotion; Male; Motor Activity; Prazosin; Rats; Rats, Wistar; Ritanserin | 1995 |
Bursting firing of action potentials in central snail neurons elicited by d-amphetamine: role of the electrogenic sodium pump.
Topics: Action Potentials; Animals; Atropine; Dextroamphetamine; Dose-Response Relationship, Drug; Edetic Acid; Esophagus; Haloperidol; Hexamethonium; Magnesium; Neurons; Ouabain; Patch-Clamp Techniques; Phenobarbital; Potassium; Prazosin; Propranolol; Snails; Sodium; Sodium-Potassium-Exchanging ATPase; Temperature; Tubocurarine; Verapamil | 1995 |
A study of effects of putative neurotransmitters injected into the lateral cerebral ventricle of man.
Topics: Adult; Blood Pressure; Body Temperature; Carbachol; Dopamine; Epinephrine; Haloperidol; Heart Rate; Humans; Injections, Intraventricular; Isoproterenol; Methysergide; Neurotransmitter Agents; Norepinephrine; Prazosin; Propranolol; Serotonin | 1993 |
Prazosin modulates the changes in firing pattern and transmitter release induced by raclopride in the mesolimbic, but not in the nigrostriatal dopaminergic system.
Topics: Animals; Brain; Corpus Striatum; Dopamine D2 Receptor Antagonists; Haloperidol; Injections, Intravenous; Limbic System; Male; Neurotransmitter Agents; Prazosin; Raclopride; Rats; Rats, Sprague-Dawley; Salicylamides; Substantia Nigra | 1994 |
On the characterization of dopamine-induced contractile response of rat anococcygeus muscle preparation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Azepines; Benzazepines; Desipramine; Dioxanes; Dopamine; Female; Haloperidol; Idazoxan; Male; Muscle Contraction; Prazosin; Rats; Receptors, Adrenergic; Receptors, Dopamine; Reserpine; Sulpiride; Yohimbine | 1994 |
Effect of 4-phenyl-1,2,3,4-tetrahydroisoquinoline on ambulation induced by injection of methamphetamine into the nucleus accumbens in rats.
Topics: Animals; Corpus Striatum; Haloperidol; Injections; Injections, Subcutaneous; Isoquinolines; Male; Methamphetamine; Motor Activity; Nucleus Accumbens; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Synaptic Membranes; Tetrahydroisoquinolines | 1993 |
Effects of haloperidol and chlorpromazine on smooth muscle contractility, platelet aggregation and neuronal calcium current.
Topics: Animals; Antipsychotic Agents; Butyrophenones; Calcium Channel Blockers; Calcium Channels; Calmodulin; Chlorpromazine; Droperidol; Electric Stimulation; Guinea Pigs; Haloperidol; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Neurons; Phenothiazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prazosin; Rats; Rats, Wistar; Snails; Sulpiride; Thrombin; Ureter; Verapamil | 1995 |
Glucocorticoids attenuate haloperidol-induced catalepsy through adrenal catecholamines.
Topics: Adrenalectomy; Animals; Catalepsy; Catecholamines; Glucocorticoids; Haloperidol; Male; Parkinson Disease; Prazosin; Rats; Time Factors | 1995 |
Long-term treatment with chlorpromazine and haloperidol but not with sulpiride and clozapine markedly elevates neuropeptide Y-like immunoreactivity in the rat hypothalamus.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Benzazepines; Chlorpromazine; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Haloperidol; Hypothalamus; Male; Neuropeptide Y; Prazosin; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D1; Sulpiride | 1996 |
Activation of alpha 1-adrenoceptors to lower cerebrocortical neuropeptide Y (NPY)-like immunoreactivity in rats receiving pargyline treatment.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antibody Specificity; Cerebral Cortex; Dopamine Antagonists; Haloperidol; Injections, Intraventricular; Male; Methoxamine; Monoamine Oxidase Inhibitors; Neuropeptide Y; Pargyline; Prazosin; Propranolol; Radioimmunoassay; Rats; Rats, Wistar | 1996 |
Effects of dopamine antagonists in a two-way active avoidance procedure in rats: interactions with 8-OH-DPAT, ritanserin, and prazosin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Prazosin; Raclopride; Rats; Rats, Sprague-Dawley; Ritanserin; Salicylamides; Serotonin Agents | 1996 |
Regulation of c-Fos and NGF1-A by antidepressant treatments.
Topics: Adrenergic Antagonists; Animals; Antidepressive Agents; Benzazepines; Blotting, Western; Dizocilpine Maleate; DNA-Binding Proteins; Dopamine Antagonists; Early Growth Response Protein 1; Electroshock; Excitatory Amino Acid Antagonists; Frontal Lobe; Genes, fos; Genes, Immediate-Early; Haloperidol; Imipramine; Immediate-Early Proteins; Ketanserin; Male; Prazosin; Propranolol; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Transcription Factors; Transcription, Genetic; Tranylcypromine | 1997 |
Neonatal handling reduces emotional reactivity and susceptibility to learned helplessness. Involvement of catecholaminergic systems.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Avoidance Learning; Behavior, Animal; Dopamine Antagonists; Escape Reaction; Female; Haloperidol; Helplessness, Learned; Male; Neurotransmitter Agents; Physical Stimulation; Prazosin; Propranolol; Rats; Rats, Wistar; Receptors, Catecholamine | 1998 |
Alpha1-adrenergic, D1, and D2 receptors interactions in the prefrontal cortex: implications for the modality of action of different types of neuroleptics.
Topics: Animals; Antipsychotic Agents; Benzazepines; Cerebral Cortex; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electric Stimulation; Electrophysiology; Haloperidol; Injections, Intravenous; Iontophoresis; Neural Inhibition; Prazosin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 1998 |
Some, but not all, antipsychotic drugs potentiate a low level of prepulse inhibition shown by rats of the Wistar strain.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Benzodiazepines; Clozapine; Haloperidol; Imidazoles; Indoles; Injections, Intraperitoneal; Male; Neural Inhibition; Olanzapine; Pirenzepine; Prazosin; Rats; Rats, Wistar; Reflex, Startle; Remoxipride; Risperidone; Ritanserin; Serotonin Antagonists | 1997 |
Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.
Topics: Allosteric Site; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Binding Sites; Biological Transport; Cell Membrane; CHO Cells; Cricetinae; Fluorescent Dyes; Flupenthixol; Haloperidol; Molecular Structure; Prazosin; Progesterone; Propranolol; Protein Binding; Rhodamine 123; Spiperone | 1999 |
Effects of l-amphetamine on the central neurons of the snail.
Topics: Action Potentials; Amphetamine; Animals; Anti-Arrhythmia Agents; Atropine; Calcium; Central Nervous System; Central Nervous System Stimulants; Dextroamphetamine; Dopamine; Drug Interactions; Haloperidol; Hexamethonium; Lithium; Magnesium; Methamphetamine; Neurons; Norepinephrine; Ouabain; Potassium; Prazosin; Propranolol; Snails; Sodium; Tubocurarine | 1999 |
Differential behavioural effect of quinpirole in neuroleptic-pretreated rats - role of alpha(1)-adrenoceptor.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Behavior, Animal; Chlorpromazine; Dopamine Agonists; Drug Synergism; Haloperidol; Injections, Intraperitoneal; Male; Motor Activity; Prazosin; Quinpirole; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Sodium Chloride; Sulpiride | 1999 |
The role of catecholamines in retention performance of a partially baited radial eight-arm maze for rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Benzazepines; Dopamine; Dopamine Antagonists; Haloperidol; Male; Maze Learning; Memory; Norepinephrine; Prazosin; Propranolol; Rats; Rats, Wistar; Space Perception; Spiperone; Yohimbine | 2002 |
Differential region-specific regulation of central alpha 1-adrenoceptor binding following chronic haloperidol and clozapine administration in the rat.
Topics: Animals; Brain; Clozapine; Haloperidol; Male; Prazosin; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 2004 |
The beta3-adrenoceptor-mediated relaxation induced by dopamine in guinea pig taenia caecum.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Benzazepines; Butoxamine; Cecum; Dopamine; Dopamine Antagonists; Guinea Pigs; Haloperidol; Male; Muscle Relaxation; Phentolamine; Prazosin; Propranolol; Receptors, Adrenergic, beta-3; Yohimbine | 2003 |
Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Catalepsy; Cell Count; Corpus Striatum; Dizocilpine Maleate; Dopamine Antagonists; Drug Interactions; Ethylenediamines; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Haloperidol; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Piperidines; Prazosin; Prosencephalon; Proto-Oncogene Proteins c-fos; Reaction Time; Receptors, N-Methyl-D-Aspartate; Time Factors | 2004 |
The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human alpha1A1-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Antipsychotic Agents; Arteries; Binding, Competitive; Calcium; Cell Line; Haloperidol; Humans; Imidazoles; Indoles; Phenylephrine; Prazosin; Protein Isoforms; Radioligand Assay; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Risperidone; Skin; Tritium; Vascular Resistance | 2008 |
Neuropeptide AF induces anxiety-like and antidepressant-like behavior in mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Anxiety; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Immobility Response, Tonic; Male; Maze Learning; Mice; Oligopeptides; Phenoxybenzamine; Prazosin; Serotonin Agents; Swimming | 2014 |