haloperidol has been researched along with phencyclidine in 214 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 65 (30.37) | 18.7374 |
| 1990's | 69 (32.24) | 18.2507 |
| 2000's | 51 (23.83) | 29.6817 |
| 2010's | 27 (12.62) | 24.3611 |
| 2020's | 2 (0.93) | 2.80 |
| Authors | Studies |
|---|---|
| Campbell, BG; Kimes, AS; London, ED; Scheffel, U; Wilson, AA | 1 |
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Bauer, C; Caldwell, L; Kinnier, WJ; Lancaster, J; McMillan, B; Price, CH; Sweetnam, PM | 1 |
| Ehret, A; Jackisch, R; Maier, CA; Predoiu, U; Soukara, S; Wünsch, B | 1 |
| Weigl, M; Wünsch, B | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Bergander, K; Fabian, J; Köhler, J; Schepmann, D; Wünsch, B | 1 |
| Finnegan, KT; Kanner, MI; Meltzer, HY | 1 |
| Varipapa, RJ | 1 |
| Horita, A; Murray, TF | 1 |
| Fox, SM | 1 |
| Berman, MH; Krewsun, I; Martin, JR; Small, SF | 1 |
| Allen, RM; Young, SJ | 1 |
| Barrett, RP; Frye, FL; Schuchman, SM | 1 |
| Bickford, PC; Kim, M | 1 |
| Alberts, WM; Brooks, SM | 1 |
| Berger, P; Butman, M; Graham, SH; Koistinaho, J; Longo, FM; Noble, L; Sagar, SM; Sharp, FR; Wang, S | 1 |
| McCullough, LD; Salamone, JD | 1 |
| deCosta, BR; Hardwick, WC; McMillan, DE; Rice, KC | 1 |
| Cone, EJ; Dodge, AL; Gund, TM; Parish, DW; Shukla, K; Su, TP; Wu, XZ | 1 |
| Barbanel, G; Kamenka, JM; Maurice, T; Vignon, J | 1 |
| Pèzzola, A; Popoli, P; Sagratella, S; Scotti de Carolis, A | 1 |
| Brent, PJ | 1 |
| Dai, JL; Xu, SF | 1 |
| Geyer, MA; Keith, VA; Mansbach, RS | 1 |
| Casanova, MF; De Souza, EB; Kleinman, JE; Weissman, AD | 1 |
| Geyer, MA; Lehmann-Masten, VD | 1 |
| Lipton, P; Lobner, D | 1 |
| Cler, JA; Contreras, PC; Dilworth, VM; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Bowen, WD; de Costa, B; Jacobson, AE; Kim, CH; Monn, JA; Reid, AA; Rice, KC; Rothman, RB; Thurkauf, A | 1 |
| Choudhary, AK; Gurtu, S; Mukherjee, D; Seth, S; Sinha, JN | 1 |
| Ohno, Y; Warnick, JE | 1 |
| Fiorica-Howells, E; Spector, S | 1 |
| Costentin, J; Duterte-Boucher, D; Kamenka, JM | 1 |
| Ahlenius, S; Ericson, E | 1 |
| Connick, JH; Fox, PK; France, L; Hanlon, GM; Nicholson, CD | 1 |
| London, ED; Vu, TH; Weissman, AD | 1 |
| Katki, AG; Rodbard, D; Schwarz, S; Zhou, GZ | 1 |
| Marien, MR; Richard, JW | 1 |
| Crespi, F; Keane, PE | 1 |
| Carp, JS; Ohno, Y; Warnick, JE | 1 |
| Culp, SG; De Souza, EB; Wolfe, SA | 1 |
| Holtzman, SG | 1 |
| Alerhand, S; Itzhak, Y | 1 |
| Allikmets, LKh; Kharro, IaE; Lang, AE; Vasar, EE | 1 |
| Duffy, O; Junien, JL; Martin, B; Pascaud, X; Roman, FJ; Vauche, D | 1 |
| Colpaert, FC; Kamenka, JM; Koek, W; Woods, JH | 1 |
| Iversen, SD; Oles, RJ; Singh, L; Tricklebank, MD; Wong, EH | 1 |
| Gibbens, H; Headley, PM; Magnago, TS; Parsons, CG | 1 |
| Battaglia, G; De Souza, EB; Jaffe, JH; Kulsakdinun, C; Wolfe, SA | 1 |
| Egan, M; Freedman, R; Kirch, DG; Palmer, MR | 1 |
| Johnson, KM; Snell, LD | 1 |
| Downes, CP; Lewis, PE; Stone, MA | 1 |
| Itoh, Y; Nishibori, M; Oishi, R; Saeki, K | 1 |
| Itzhak, Y | 2 |
| Altar, CA; Marien, MR | 1 |
| Wessinger, WD | 1 |
| Kameyama, T; Nabeshima, T; Yamaguchi, K | 2 |
| Bagley, RB; Compton, DR; Katzen, JS; Martin, BR | 1 |
| Freedman, R; Hoffer, BJ; Johnson, SW | 1 |
| Arasteh, K; Trulson, ME | 1 |
| DiMarzio, LR; Giannini, AJ; Giannini, MC; Loiselle, RH | 1 |
| Dykstra, LA; Woods, JH | 1 |
| Adler, LE; Freedman, R; Rose, G | 1 |
| Kokkinidis, L | 1 |
| McMillan, DE; Rastogi, SK | 1 |
| Clark, RD; Katz, JL; Spealman, RD | 1 |
| Giannini, AJ; Loiselle, RH; Malone, DW; Price, WA | 1 |
| Amano, M; Furukawa, H; Kameyama, T; Nabeshima, T; Yamaguchi, K; Yoshida, S | 1 |
| McGill, DB; Motto, JD | 1 |
| Bass, WC; Brown, H | 1 |
| Gannon, RL; Johnson, KM; Mueller, ZL; Silverman, PB; Snell, LD | 1 |
| Bunney, BS; Freeman, AS | 1 |
| Johnson, KM | 1 |
| Conn, LM; Lion, JR | 1 |
| Peterson, MR; Robertson, HA | 1 |
| Johnson, KM; Leventer, SM | 1 |
| Masters, DB; Tomie, A; Wagner, GC | 1 |
| Forney, RB; Haggerty, GC; Richter, JA | 1 |
| Franko, CM; Tomie, A; Wagner, GC | 1 |
| Eighan, MS; Giannini, AJ; Giannini, MC; Loiselle, RH | 1 |
| Brocco, M; McMillan, DE | 1 |
| Freedman, R; Hoffer, B; Marwaha, J; Palmer, M | 2 |
| Ellison, G; Nelson, L; Potthoff, AD | 1 |
| Miczek, KA; Tyler, CB | 1 |
| Adams, PM; Boeringa, JA; Castellani, S; Giannini, AJ | 1 |
| Bayorh, MA; Kopin, IJ; Lozovsky, D; Saller, CF; Zerbe, RL | 1 |
| Garey, RE; Heath, RG; McQuitty, S; Tootle, D | 1 |
| Johnson, KM; Oeffinger, KC | 1 |
| Adams, PM; Castellani, S | 1 |
| Doherty, JD; Meltzer, HY; Simonovic, M; So, R | 1 |
| Furukawa, H; Hasegawa, T; Kitaichi, K; Nabeshima, T; Yamada, K | 1 |
| Furukawa, H; Hasegawa, T; Kitaichi, K; Nabeshima, T; Ogita, K; Yamada, K; Yoneda, Y | 1 |
| Jackson, DM; Johansson, C; Svensson, L | 1 |
| Liu, Y; Pultz, JA; Whitlock, BB; Wolfe, SA | 1 |
| Goldstein, M; Ogren, SO | 1 |
| Maurice, T; Nabeshima, T; Parish, DW; Privat, A; Su, TP | 1 |
| Kovács, KJ; Larson, AA | 1 |
| Dannals, RF; Mathews, WB; Musachio, JL; Ravert, HT; Scheffel, U; Stathis, M | 1 |
| Demers, PA; Demers, RY; Schade, WJ | 1 |
| Larson, AA; Sun, X | 1 |
| Chaki, S; Imagawa, Y; Muramatsu, M; Okuyama, S; Otomo, S; Tanaka, M | 1 |
| Papanikolaou, A; Salamone, JD; Sokolowski, JD; Steinpreis, RE | 1 |
| Shi, GG; Xu, SF | 1 |
| Berger, P; Butman, M; Graham, SH; Koistinaho, J; Longo, FM; Sagar, SM; Sharp, FR; Wang, S | 1 |
| Wiley, JL | 1 |
| Brum, JM; Estafanous, FG; Murray, PA; Schubert, A; Tsuchida, H | 1 |
| Chang, J; Nakki, R; Nickolenko, J; Sagar, SM; Sharp, FR | 1 |
| Hashimoto, K; Hirano, M; Hondo, H; Matsumoto, T; Nakamura, K; Nakane, H; Tsukashima, A; Tsutsumi, T; Uchimura, H; Yonezawa, Y | 1 |
| Chen, X; Hurlbert, M; Joseph, DB; Kumar, KN; Michaelis, EK; Michaelis, ML | 1 |
| Banks, DA; Flory, GS; Hooper, KC; Rebec, GV; Speciale, J; White, IM | 1 |
| Estlander, T; Henriks-Eckerman, ML; Jolanki, R; Kanerva, L; Mustakallio, KK; Tarvainen, K; Tatar, T | 1 |
| Baba, A; Goji, K; Kawai, N; Moroji, T; Yamamoto, H; Yamamoto, T; Yang, X | 1 |
| Bakshi, V; Geyer, MA; Swerdlow, NR | 1 |
| Cordon, JJ; Coughenour, LL | 1 |
| Gleason, SD; Shannon, HE | 1 |
| McAllister, KH | 1 |
| Furuya, Y; Kagaya, T; Nishizawa, Y; Ogura, H | 1 |
| Sams-Dodd, F | 1 |
| Curzon, P; Decker, MW | 1 |
| Ossowska, K; Pietraszek, M | 1 |
| Liang, X; Wang, RY | 1 |
| Jentsch, JD; Roth, RH; Taylor, JR | 1 |
| Nishikawa, T; Takahashi, K; Umino, A | 1 |
| Campbell, IG; Feinberg, I | 1 |
| Hashimoto, T; Kajii, Y; Nishikawa, T | 1 |
| Elsworth, JD; Jentsch, JD; Redmond, DE; Roth, RH; Taylor, JR; Youngren, KD | 1 |
| Arvanov, VL; Wang, RY | 1 |
| Ahmed, MS; Enna, SJ; Mather, A | 1 |
| Freeman, S; Kumar, A | 1 |
| Caron, MG; Gainetdinov, RR; Koller, BH; Mohn, AR | 1 |
| Horikomi, K; Iizuka, K; Mita, N; Miwa, T; Nagase, H; Sakai, K; Sonehara, K; Takagi, K; Takahashi, S | 1 |
| Fukuda, K; Hondo, H; Kuroki, T; Nakahara, T; Tsutsumi, T; Uchimura, H; Yao, H | 1 |
| Mitsushio, H; Nishikawa, T; Shirayama, Y; Takahashi, K | 1 |
| Hashimoto, K; Hirano, M; Hondo, H; Kuroki, T; Motomura, K; Nakahara, T; Tsutsumi, T; Uchimura, H; Ueki, H | 1 |
| Sabel, BA; Schroeder, H; Schroeder, U; Schwegler, H | 1 |
| Ellison, GD; Geyer, MA; Martinez, ZA; Oostwegel, J; Swerdlow, NR | 1 |
| Furukawa, H; Kamei, H; Kayukawa, Y; Miura, H; Nabeshima, T; Nagai, T; Noda, Y; Ohta, T; Qiao, H | 1 |
| Dai, J; Guan, HJ; Zhu, XZ | 1 |
| Kanazir, S; Rakic, L; Ruzdijic, S; Veskov, R; Vukosavic, S | 1 |
| Adams, BW; Moghaddam, B | 1 |
| Breese, GR; Moy, SS | 1 |
| Breese, GR; Knapp, DJ; Moy, SS | 1 |
| Dean, B; Parkin, FM; Pavey, G; Scarr, E | 1 |
| Herman, ZS; Obuchowicz, E | 1 |
| Jardemark, KE; Ninan, I; Wang, RY | 1 |
| Abdul-Monim, Z; Neill, JC; Reynolds, GP | 1 |
| Coyle, JT; Flores, C | 1 |
| Gerum, SV; Javitt, DC; Linn, GS; Negi, SS | 1 |
| Abekawa, T; Honda, M; Ito, K; Koyama, T | 1 |
| JOYNER, RE; PEGUES, WL | 1 |
| CLARKE, HL; GOOL, RY | 1 |
| Engel, JA; Klamer, D; Pålsson, E; Revesz, A; Svensson, L | 1 |
| Araki, H; Choshi, T; Gomita, Y; Hibino, S; Shibata, K; Suemaru, K; Umeda, K; Yasuda, K | 1 |
| Idris, NF; Large, CH; Neill, JC; Repeto, P | 1 |
| Chartoff, EH; Heusner, CL; Palmiter, RD | 1 |
| Barnouin, MC; Chabot, C; Depoortere, R; Griebel, G; Perrault, G; Scatton, B; Terranova, JP | 1 |
| Bruins Slot, LA; Kleven, MS; Newman-Tancredi, A | 1 |
| Fujita, Y; Hashimoto, K; Iyo, M; Shimizu, E | 1 |
| Adell, A; Amargós-Bosch, M; Artigas, F; López-Gil, X | 1 |
| Morris, BJ; Ohashi, Y; Paterson, GJ; Pratt, JA; Reynolds, GP | 1 |
| Chambers, L; Chapin, DS; Harms, JF; Lebel, LA; McCarthy, SA; Menniti, FS; Schmidt, CJ; Shrikhande, A; Siuciak, JA; Wong, S | 1 |
| Dunn, MJ; Killcross, S | 2 |
| Abekawa, T; Ito, K; Koyama, T | 1 |
| Engel, JA; Fejgin, K; Klamer, D; Pålsson, E; Safonov, S; Svensson, L; Wass, C | 1 |
| Hulick, VC; Turgeon, SM | 1 |
| Arnt, J; Didriksen, M; Skarsfeldt, T | 1 |
| Amitai, N; Markou, A; Semenova, S | 1 |
| Artigas, F; Celada, P; Kargieman, L; Mengod, G; Santana, N | 2 |
| Neill, JC; Snigdha, S | 1 |
| Beraki, S; Kuzmin, A; Ogren, SO; Tai, F | 1 |
| Beck, JP; McLean, SL; Neill, JC; Woolley, ML | 1 |
| Dias, R; Goetghebeur, P | 1 |
| Furukawa, H; Kamei, H; Matsui, K; Murai, R; Nabeshima, T; Nagai, T; Noda, Y | 1 |
| Barlow, KB; Kapur, S; Natesan, S; Nobrega, JN; Reckless, GE | 1 |
| Hu, G; Li, M; Sun, T | 1 |
| Abou-Jamra, R; Beck, H; Benzel, I; Bilkei-Gorzó, A; Filiou, MD; Holst, MI; Kunz, WS; Otte, DM; Schilling, K; Schumacher, J; Turck, CW; Yilmaz, O; Zimmer, A | 1 |
| Nishikawa, T; Takebayashi, H; Umino, A; Yamamoto, N | 1 |
| Caselli, G; Chiusaroli, R; Espinoza, S; Garofalo, P; Lanza, M; Neri, E | 1 |
| Arrang, JM; Burban, A; Dumoulin, D; Frances, H; Le Pen, G; Rose, C; Sadakhom, C | 1 |
| Dias, R; Goetghebeur, PJ; Lerdrup, L; Sylvest, A | 1 |
| He, E; Li, M; Volf, N | 1 |
| Farrell, MS; Kroeze, WK; Roth, BL; Yadav, PN | 1 |
| Li, M; Zhang, C | 1 |
| Li, M; Sun, T; Zhao, C | 1 |
| Bradaia, A; Bruns, A; Buchy, D; Chaboz, S; Galley, G; Groebke Zbinden, K; Hoener, MC; Kilduff, TS; Metzler, V; Morairty, SR; Moreau, JL; Mory, R; Norcross, RD; Pouzet, B; Revel, FG; Risterucci, C; Tuerck, D; Wallace, TL; Wettstein, JG | 1 |
| Adelekun, AE; Hannaway, KE; Horiguchi, M; Jayathilake, K; Meltzer, HY | 1 |
| Fuchs, T; Geier, J; Krautheim, A | 1 |
| Cone, DC; MacNeal, JJ; Sinha, V; Tomassoni, AJ | 1 |
| Aoyama, Y; Ikawa, N; Koseki, T; Mamiya, T; Mouri, A; Nabeshima, T; Nagai, T; Narusawa, S; Toriumi, K; Yamada, K | 1 |
| Li, M; Liu, X; Sun, T | 1 |
| Horiguchi, M; Meltzer, HY; Miyauchi, M; Oyamada, Y; Rajagopal, L | 1 |
| Habata, Y; Imaichi, S; Komatsu, H; Maruyama, M; Mori, M; Sakuma, K | 1 |
| Amato, D; Carey, RJ; de Souza Silva, MA; Groos, D; Huston, JP; Lauber, AC; Müller, CP; Pum, ME | 1 |
| Campos, MM; Costa, KM; Leite, CE; Pail, PB | 1 |
| Huang, M; Kwon, S; Meltzer, HY; Miyauchi, M; Oyamada, Y; Rajagopal, L | 1 |
| Carlson, S; Chen, F; Huang, H; Jianhong, W; Ren, H; Tian, C; Wen, C; Wu, Z; Ya, J; Yu, H; Zheng, S | 1 |
| Jang, CG; Jeong, JH; Kim, HC; Lee, JW; Lee, Y; Lei, XG; Nabeshima, T; Nah, SY; Shin, EJ; Toriumi, K; Tran, TV; Yamada, K | 1 |
| Ding, X; Hu, G; Li, M; Li, X; Shu, Q; Wu, R | 1 |
| Aksić, M; Jevtić Dožudić, G; Nikolić, T; Petronijević, M; Petronijević, N; Radonjić, NV; Sopta, J; Stojković, T; Velimirović, M | 1 |
| Borrelli, E; Caron, MG; Pack, TF; Payne, K; Peterson, SM; Rose, SJ | 1 |
| Cao, T; Chen, J; Jiang, Y; Waddington, JL; Wang, C; Wang, P; Zhen, X | 1 |
| Delgado-Sallent, C; Fath, AB; Gener, T; Nebot, P; Puig, MV; Timplalexi, M | 1 |
| Artigas, F; Celada, P; Didriksen, M; Paz, V; Riga, MS | 1 |
4 review(s) available for haloperidol and phencyclidine
| Article | Year |
|---|---|
The role of receptor binding in drug discovery.
Topics: Animals; Drug Design; Humans; Receptors, Drug | 1993 |
Advances in occupational asthma.
Topics: Allergens; Asthma; Cyanates; Disability Evaluation; Dust; Epoxy Resins; Humans; Occupational Diseases; Prevalence; Prognosis; Resins, Plant; Respiration Disorders; Salts; Tars; Wood; Workers' Compensation | 1992 |
Pharmacologic approaches to violence.
Topics: Aggression; Anticonvulsants; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzodiazepines; Cognition Disorders; Crisis Intervention; Dystonia; Emergency Services, Psychiatric; Haloperidol; Humans; Mood Disorders; Neurocognitive Disorders; Personality Disorders; Phencyclidine; Violence | 1984 |
Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness.
Topics: Animals; Antipsychotic Agents; Behavior; Behavior, Animal; Brain; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Haloperidol; Humans; Phencyclidine; Psychoses, Substance-Induced; Receptors, Dopamine; Receptors, Glutamate; Receptors, Serotonin; Schizophrenia | 2002 |
2 trial(s) available for haloperidol and phencyclidine
| Article | Year |
|---|---|
Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication.
Topics: Adult; Ascorbic Acid; Drug Synergism; Drug Therapy, Combination; Haloperidol; Humans; Male; Phencyclidine; Phencyclidine Abuse; Psychiatric Status Rating Scales; Psychoses, Substance-Induced | 1987 |
Treatment of phenylcyclohexylpyrrolidine (PHP) psychosis with haloperidol.
Topics: Haloperidol; Humans; Male; Phencyclidine; Psychoses, Substance-Induced | 1985 |
208 other study(ies) available for haloperidol and phencyclidine
| Article | Year |
|---|---|
Radiosynthesis, cerebral distribution, and binding of [125I]-1-(p-iodophenyl)-3-(1-adamantyl)guanidine, a ligand for sigma binding sites.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Brain; Guanidines; Guinea Pigs; Iodobenzenes; Male; Mice; Receptors, sigma; Tissue Distribution | 1992 |
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functio
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Animals; Binding Sites; Brain; Electric Stimulation; Guinea Pigs; Hippocampus; In Vitro Techniques; Piperazines; Pyrrolidines; Rabbits; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship | 2001 |
Synthesis of bridged piperazines with sigma receptor affinity.
Topics: Cross-Linking Reagents; Molecular Structure; Piperazine; Piperazines; Receptors, sigma | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Enantiomerically pure 1,3-dioxanes as highly selective NMDA and σ₁ receptor ligands.
Topics: Animals; Benzylamines; Binding Sites; Binding, Competitive; Cerebral Cortex; Dioxanes; Ethylamines; Guinea Pigs; Ligands; Phencyclidine; Radioligand Assay; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stereoisomerism; Swine | 2012 |
Phencyclidine-induced rotational behavior in rats with nigrostriatal lesions and its modulation by dopaminergic and cholinergic agents.
Topics: Animals; Arecoline; Behavior; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Humans; Male; Methyltyrosines; Parasympathomimetics; Phencyclidine; Pimozide; Rats; Receptors, Dopamine; Stereotaxic Techniques; Stereotyped Behavior; Substantia Nigra; Time Factors; Trihexyphenidyl; Tyrosine 3-Monooxygenase | 1976 |
PCP treatment.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Haloperidol; Humans; Phencyclidine; Phenothiazines; Physostigmine | 1977 |
Phencyclidine-induced stereotyped behavior in rats: dose response effects and antagonism by neuroleptics.
Topics: Animals; Antipsychotic Agents; Behavior; Chlorpromazine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Motor Activity; Phencyclidine; Pimozide; Rats; Stereotyped Behavior; Time Factors | 1979 |
Haloperidol in the treatment of phencyclidine intoxication.
Topics: Haloperidol; Humans; Phencyclidine; Psychoses, Substance-Induced | 1979 |
Phencyclidine-induced stereotyped behavior and serotonergic syndrome in rat.
Topics: Animals; Behavior; Cinanserin; Cyproheptadine; Drug Interactions; Haloperidol; Humans; Male; Motor Activity; Phencyclidine; Rats; Serotonin; Stereotyped Behavior | 1979 |
Phencyclidine-induced psychosis.
Topics: Adolescent; Adult; Female; Haloperidol; Humans; Male; Military Medicine; Phencyclidine; Psychoses, Substance-Induced; Substance-Related Disorders; Texas | 1978 |
Toxicities and harzards for clinicians in small animal practice.
Topics: Aerosols; Dust; Environmental Exposure; Epoxy Resins; Female; Halothane; Humans; Insecticides; Male; Methacrylates; Occupational Diseases; Organophosphorus Compounds; Osmium; Physical Examination; Poisoning; Pregnancy; Radiation Injuries; Radiography; Veterinary Medicine | 1975 |
Electrophysiological effects of phencyclidine and the sigma agonist ditolylguanidine in the cerebellum of the rat.
Topics: Animals; Cerebellum; Electrophysiology; Guanidines; Haloperidol; Male; Norepinephrine; Oxidopamine; Phencyclidine; Purkinje Fibers; Rats; Rats, Inbred Strains; Synaptic Transmission | 1992 |
Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine.
Topics: Amygdala; Animals; Base Sequence; Carbazoles; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Gene Expression; Haloperidol; Heat-Shock Proteins; Humans; Immunohistochemistry; Ketamine; Kinetics; Microscopy, Electron; Molecular Sequence Data; Neurons; Oligodeoxyribonucleotides; Oligonucleotides, Antisense; Phencyclidine; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reference Values; Restriction Mapping; RNA, Messenger | 1992 |
Increases in extracellular dopamine levels and locomotor activity after direct infusion of phencyclidine into the nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catheters, Indwelling; Dialysis; Dopamine; Haloperidol; Homovanillic Acid; Infusions, Parenteral; Injections; Male; Motor Activity; Nucleus Accumbens; Perfusion; Phencyclidine; Rats; Rats, Inbred Strains | 1992 |
Effects of drugs that bind to PCP and sigma receptors on punished responding.
Topics: Animals; Buspirone; Dizocilpine Maleate; Haloperidol; Learning; Male; Pentobarbital; Phenazocine; Phencyclidine; Punishment; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1991 |
Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand.
Topics: Animals; Guinea Pigs; Haloperidol; Male; Molecular Conformation; Morpholines; Phencyclidine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Structure-Activity Relationship | 1991 |
Modulation by dopamine of [3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP, a phencyclidine derivative) binding to the dopamine uptake complex.
Topics: alpha-Methyltyrosine; Animals; Benserazide; Cocaine; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Haloperidol; In Vitro Techniques; Levodopa; Male; Membrane Proteins; Methyltyrosines; Mice; Nerve Tissue Proteins; Phencyclidine; Piperazines; Rats; Reserpine | 1991 |
Behavioural and electoencephalographic interactions between haloperidol and PCP/sigma ligands in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Catalepsy; Electroencephalography; Haloperidol; Isoquinolines; Kinetics; Male; Phenazocine; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma; Spiperone | 1991 |
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Dizocilpine Maleate; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; Guanidines; Guinea Pigs; Haloperidol; Ketamine; Male; Motor Activity; N-Methylaspartate; Pentazocine; Phenazocine; Phencyclidine; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride | 1991 |
Effects of phencyclidine on contractile forces of isolated rabbit papillary muscles.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Dextrorphan; Female; Haloperidol; Male; Myocardial Contraction; Papillary Muscles; Phencyclidine; Rabbits; Stimulation, Chemical; Sulpiride | 1991 |
Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle.
Topics: Animals; Arousal; Attention; Brain; Dizocilpine Maleate; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Loudness Perception; Male; Neural Inhibition; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Touch | 1991 |
PCP and sigma receptors in brain are not altered after repeated exposure to PCP in humans.
Topics: Adolescent; Adult; Brain; Brain Chemistry; Female; Haloperidol; Humans; Male; Middle Aged; Phencyclidine; Radioligand Assay; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1991 |
Spatial and temporal patterning distinguishes the locomotor activating effects of dizocilpine and phencyclidine in rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Exploratory Behavior; Haloperidol; Male; Motor Activity; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains | 1991 |
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate; Glutamates; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Ketamine; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Pyramidal Tracts; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1990 |
Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Ligands; Male; Mice; Opipramol; Organ Specificity; Phencyclidine; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1990 |
Wash-resistant inhibition of phencyclidine- and haloperidol-sensitive sigma receptor sites in guinea pig brain by putative affinity ligands: determination of selectivity.
Topics: Affinity Labels; Animals; Brain; Cerebellum; Dizocilpine Maleate; Guinea Pigs; Haloperidol; Kinetics; Ligands; Membranes; Phencyclidine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1990 |
Opioid and non-opioid central cardiovascular effects of ketamine.
Topics: Animals; Blood Pressure; Cats; Cisterna Magna; Dose-Response Relationship, Drug; Haloperidol; Heart Rate; Hemodynamics; Injections; Ketamine; Naloxone; Phencyclidine; Pimozide; Receptors, Opioid; Receptors, sigma | 1990 |
Selective depression of the segmental polysynaptic reflex by phencyclidine and its analogs in the rat in vitro: interaction with N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Binding Sites; Haloperidol; In Vitro Techniques; Magnesium; Male; Methiothepin; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Spinal Cord | 1990 |
Selectivity of some "specific" opioid ligands?
Topics: Animals; Benzomorphans; Binding, Competitive; Brain; Dynorphins; Female; Haloperidol; In Vitro Techniques; Mice; Morphinans; Peptide Fragments; Phencyclidine; Piperidines; Receptors, Opioid | 1990 |
Comparison of the effects of three indirect dopamine agonists, GK 13, GBR 12783 and dexamphetamine on behavioural tests involving central catecholaminergic transmissions.
Topics: Animals; Behavior, Animal; Blepharoptosis; Body Temperature; Brain Chemistry; Catecholamines; Dextroamphetamine; Dopamine Agents; Drinking; Eating; Haloperidol; Male; Mice; Phencyclidine; Piperazines; Postural Balance; Rats; Rats, Inbred Strains; Reflex; Stereotyped Behavior; Synaptic Transmission | 1990 |
Phencyclidine-induced disruption of an aversely motivated two-choice successive discrimination in the rat.
Topics: Amphetamine; Animals; Antipsychotic Agents; Avoidance Learning; Benzamides; Discrimination Learning; Discrimination, Psychological; Drug Interactions; Haloperidol; Male; Phencyclidine; Rats; Rats, Inbred Strains; Remoxipride | 1990 |
The lack of utility of the rat vas deferens as a functional bioassay for sigma ligands.
Topics: Animals; Binding Sites; Biological Assay; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; Male; Muscle Contraction; Pentazocine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
Pharmacological characteristics and distributions of sigma- and phencyclidine receptors in the animal kingdom.
Topics: Animals; Binding Sites; Chickens; Fishes; Guinea Pigs; Haloperidol; Male; Phencyclidine; Phylogeny; Ranidae; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Saimiri; Sea Anemones; Turtles | 1990 |
Differential modulation by cations of sigma and phencyclidine binding sites in rat brain.
Topics: Animals; Binding Sites; Brain; Cations; Dose-Response Relationship, Drug; Haloperidol; Ligands; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Sigma Factor; Tritium | 1990 |
Drug effects on the release of endogenous acetylcholine in vivo: measurement by intracerebral dialysis and gas chromatography-mass spectrometry.
Topics: Acetylcholine; Animals; Atropine; Chromatography, Gas; Consciousness; Corpus Striatum; Dialysis; Haloperidol; Magnesium; Male; Mass Spectrometry; Phencyclidine; Physostigmine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Tetrodotoxin | 1990 |
Analysis of extracellular DOPAC, HVA and 5-HIAA in rat striatum in vivo by differential pulse voltammetry: effect of phencyclidine, haloperidol and their coadministration.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Corpus Striatum; Drug Interactions; Electric Stimulation; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Phencyclidine; Phenylacetates; Rats; Rats, Inbred Strains | 1987 |
Prevention of phencyclidine-induced depression of the segmental reflex by L-3,4-dihydroxyphenylalanine in the rat spinal cord in vitro.
Topics: Animals; Chlorpromazine; Dihydroxyphenylalanine; Electric Stimulation; Female; Haloperidol; Hydroxydopamines; In Vitro Techniques; Male; Oxidopamine; Phencyclidine; Phentolamine; Rats; Rats, Inbred Strains; Reflex; Spinal Cord | 1989 |
Sigma-receptors in endocrine organs: identification, characterization, and autoradiographic localization in rat pituitary, adrenal, testis, and ovary.
Topics: Adrenal Glands; Animals; Autoradiography; Brain Chemistry; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Haloperidol; Hypophysectomy; Male; Ovary; Phencyclidine; Piperidines; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Testis; Tissue Distribution | 1989 |
Opioid- and phencyclidine-like discriminative effects of ditolylguanidine, a selective sigma ligand.
Topics: Animals; Benzomorphans; Cyclazocine; Discrimination Learning; Ethylketocyclazocine; Generalization, Psychological; Guanidines; Haloperidol; Levorphanol; Male; Naltrexone; Narcotics; Phencyclidine; Rats; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1989 |
Differential regulation of sigma and PCP receptors after chronic administration of haloperidol and phencyclidine in mice.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Hallucinogens; Haloperidol; Male; Mice; Mice, Inbred Strains; Phenazocine; Phencyclidine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Time Factors | 1989 |
[Adaptive changes in sigma and phencyclidine receptors during the long-term use of haloperidol and raclopride in rats].
Topics: Adaptation, Physiological; Animals; Apomorphine; Behavior, Animal; Drug Interactions; Haloperidol; Ketamine; Phenazocine; Phencyclidine; Raclopride; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Salicylamides; Time Factors; Tritium | 1989 |
Neuropeptide Y and peptide YY interact with rat brain sigma and PCP binding sites.
Topics: Animals; Brain Chemistry; Haloperidol; In Vitro Techniques; Male; Neuropeptide Y; Pentazocine; Peptide YY; Peptides; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1989 |
The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801.
Topics: Animals; Behavior, Animal; Cocaine; Columbidae; Dextroamphetamine; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Haloperidol; Ketamine; Methylphenidate; Mice; Phencyclidine; Rats; Seizures; Structure-Activity Relationship | 1989 |
A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine.
Topics: Animals; Discrimination, Psychological; Generalization, Stimulus; Haloperidol; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
At which 'sigma' site are the spinal actions of ketamine mediated?
Topics: Action Potentials; Animals; Binding, Competitive; Dibenzocycloheptenes; Dizocilpine Maleate; Haloperidol; Ketamine; Male; Motor Neurons; Nociceptors; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Spinal Cord | 1988 |
Initial identification and characterization of sigma receptors on human peripheral blood leukocytes.
Topics: Animals; Guanidines; Haloperidol; Leukocytes; Lymphocyte Activation; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia | 1988 |
Electrophysiological interactions between haloperidol and reduced haloperidol, and dopamine, norepinephrine and phencyclidine in rat brain.
Topics: Animals; Antipsychotic Agents; Brain; Catecholamines; Dopamine Antagonists; Haloperidol; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Synaptic Transmission | 1985 |
Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.
Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Aspartic Acid; Benzomorphans; Chlorpromazine; Clozapine; Corpus Striatum; Cyclazocine; Dioxolanes; Dopamine; Haloperidol; Ketamine; Male; Mathematics; Motor Activity; N-Methylaspartate; Phencyclidine; Posture; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
A comparison of the binding of sigma opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Corpus Striatum; Endorphins; Haloperidol; In Vitro Techniques; Male; Membranes; Phenazocine; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Involvement of opioid receptors in phencyclidine-induced enhancement of brain histamine turnover in mice.
Topics: Analgesics, Opioid; Animals; Brain; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Haloperidol; Histamine; Histidine Decarboxylase; Ketamine; Male; Methylhistidines; Mice; Naloxone; Pargyline; Phenazocine; Phencyclidine; Receptors, Opioid | 1987 |
Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Haloperidol; In Vitro Techniques; Male; Phenazocine; Phencyclidine; Piperidines; Psychotropic Drugs; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1988 |
[3H]vesamicol binding in brain: autoradiographic distribution, pharmacology, and effects of cholinergic lesions.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Autoradiography; Brain; Cholinergic Fibers; Frontal Lobe; Haloperidol; Hippocampus; Image Processing, Computer-Assisted; Ketanserin; Male; Neural Pathways; Neurotransmitter Uptake Inhibitors; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains | 1988 |
Approaches to the study of drug interactions in behavioral pharmacology.
Topics: Alkaloids; Animals; Behavior, Animal; Brain; Chloral Hydrate; Cocaine; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Haloperidol; Humans; Phencyclidine; Phenobarbital; Synaptic Transmission | 1986 |
Role of dopaminergic and GABAergic mechanisms in discrete brain areas in phencyclidine-induced locomotor stimulation and turning behavior.
Topics: Animals; Behavior, Animal; Brain; Catalepsy; Caudate Nucleus; Dopamine; Globus Pallidus; Haloperidol; Male; Methamphetamine; Motor Activity; Nucleus Accumbens; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, GABA-A; Reserpine; Stereotyped Behavior | 1986 |
(+)- and (-)-N-allylnormetazocine binding sites in mouse brain: in vitro and in vivo characterization and regional distribution.
Topics: Animals; Binding, Competitive; Brain; Cyclazocine; Ethylketocyclazocine; Haloperidol; In Vitro Techniques; Mice; Naloxone; Phenazocine; Phencyclidine; Receptors, Opioid; Receptors, sigma; Stereoisomerism | 1987 |
[3H]PCP-3-OH and (+)[3H]SKF 10047 binding sites in rat brain membranes: evidence of multiplicity.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Haloperidol; In Vitro Techniques; Phenazocine; Phencyclidine; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Investigation of the failure of parenterally administered haloperidol to antagonize dopamine released from micropipettes in the caudate.
Topics: Amphetamine; Animals; Apomorphine; Caudate Nucleus; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Hydroxydopamines; Infusions, Parenteral; Male; Oxidopamine; Phencyclidine; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Phencyclidine suppresses the activity of midbrain dopamine-containing neurons recorded from mouse brain slices in vitro.
Topics: alpha-Methyltyrosine; Animals; Depression, Chemical; Dopamine; Drug Interactions; Haloperidol; In Vitro Techniques; Male; Methyltyrosines; Mice; Phencyclidine; Substantia Nigra; Tegmentum Mesencephali | 1987 |
Role of dopaminergic and serotonergic neuronal systems in the prefrontal cortex of rats in phencyclidine-induced behaviors.
Topics: Animals; Apomorphine; Caudate Nucleus; Cyclazocine; Dopamine; Frontal Lobe; Haloperidol; Male; Motor Activity; Nucleus Accumbens; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Stereotyped Behavior | 1986 |
A tail withdrawal procedure for assessing analgesic activity in rhesus monkeys.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Female; Haloperidol; Hot Temperature; Male; Morphine; Pain; Pentobarbital; Phencyclidine; Reaction Time | 1986 |
Neurophysiological studies of sensory gating in rats: effects of amphetamine, phencyclidine, and haloperidol.
Topics: Animals; Auditory Pathways; Auditory Perception; Brain; Conditioning, Psychological; Dextroamphetamine; Drug Interactions; Evoked Potentials, Auditory; Haloperidol; Male; Phencyclidine; Rats; Rats, Inbred Strains | 1986 |
Sensitization to amphetamine and tolerance to cocaine and phencyclidine stimulation in mice.
Topics: Animals; Cocaine; Dextroamphetamine; Drug Resistance; Drug Tolerance; Habituation, Psychophysiologic; Haloperidol; Mice; Phencyclidine; Reflex, Startle | 1986 |
Effects of drugs on schedule-controlled behavior in rats during chronic haloperidol administration.
Topics: Animals; Cimetidine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Meperidine; Morphine; Phencyclidine; Rats; Rats, Inbred Strains; Reinforcement Schedule; Time Factors | 1985 |
Stereoselective behavioral effects of N-allylnormetazocine in pigeons and squirrel monkeys.
Topics: Animals; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Morphine; Naloxone; Phenazocine; Phencyclidine; Reinforcement Schedule; Saimiri; Stereoisomerism | 1985 |
Phencyclidine-induced dopamine-dependent behaviors in chronic haloperidol-treated rats.
Topics: Animals; Apomorphine; Behavior, Animal; Biogenic Amines; Brain Chemistry; Dopamine; Haloperidol; Male; Methamphetamine; Phencyclidine; Rats; Rats, Inbred F344; Stereotyped Behavior | 1985 |
An industrial outbreak of toxic hepatitis due to methylenedianiline.
Topics: Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Disease Outbreaks; Dust; Environmental Exposure; Epoxy Resins; Hand; Humans; Liver; Male; Occupational Diseases; Protective Clothing; Retrospective Studies; Skin Absorption; Time Factors | 1974 |
Effect of drugs on visually controlled avoidance behavior in rhesus monkeys: a psychophysical analysis.
Topics: Anesthetics; Animals; Avoidance Learning; Caffeine; Chlorpromazine; Dextroamphetamine; Escape Reaction; Hallucinogens; Haloperidol; Haplorhini; Lysergic Acid Diethylamide; Male; Morphine; Parasympatholytics; Pentobarbital; Phencyclidine; Piperidines; Psychopharmacology; Size Perception; Strychnine; Visual Perception | 1967 |
A comparison between classes of drugs having phencyclidine-like behavioral properties on dopamine efflux in vitro and dopamine metabolism in vivo.
Topics: Animals; Corpus Striatum; Dopamine; Haloperidol; In Vitro Techniques; Ketamine; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Receptors, Phencyclidine; Structure-Activity Relationship | 1984 |
The effects of phencyclidine and N-allylnormetazocine on midbrain dopamine neuronal activity.
Topics: Animals; Haloperidol; Iontophoresis; Male; Mesencephalon; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Receptors, Phencyclidine; Stereoisomerism | 1984 |
Phencyclidine: behavioral and biochemical evidence supporting a role for dopamine.
Topics: Animals; Behavior, Animal; Brain; Corpus Striatum; Dextroamphetamine; Dopamine; Haloperidol; Humans; Male; Mice; Monoamine Oxidase; Motor Activity; Phencyclidine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1983 |
Effect of dopaminergic agents on levels of dynorphin1-8 in rat striatum.
Topics: Animals; Corpus Striatum; Dextroamphetamine; Dynorphins; Haloperidol; Male; Phencyclidine; Radioimmunoassay; Rats; Rats, Inbred Strains | 1984 |
Phencyclidine-induced inhibition of striatal acetylcholine release: comparisons with mu, kappa, and sigma opiate agonists.
Topics: Acetylcholine; Animals; Corpus Striatum; Cyclazocine; Ethylketocyclazocine; Haloperidol; Male; Morphine; Naloxone; Narcotic Antagonists; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains | 1984 |
Effects of phencyclidine, haloperidol, and naloxone on fixed-interval performance in rats.
Topics: Animals; Conditioning, Operant; Haloperidol; Male; Naloxone; Phencyclidine; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1984 |
The effects of an in vivo administration of phencyclidine on sodium-dependent high affinity choline uptake in rat hippocampus and striatum in vitro.
Topics: Amphetamine; Animals; Behavior, Animal; Choline; Corpus Striatum; Drug Interactions; Haloperidol; Hippocampus; In Vitro Techniques; Male; Phencyclidine; Rats; Rats, Inbred Strains; Sodium; Synaptosomes | 1983 |
Interactions of naloxone and haloperidol with phencyclidine: effects on milk intake.
Topics: Animals; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Haloperidol; Male; Milk; Naloxone; Phencyclidine; Rats; Rats, Inbred Strains | 1984 |
Comparison of haloperidol and chlorpromazine in the treatment of phencyclidine psychosis.
Topics: Adult; Chlorpromazine; Haloperidol; Humans; Injections, Intramuscular; Male; Phencyclidine; Psychiatric Status Rating Scales; Psychoses, Substance-Induced | 1984 |
Modification of drug effects by l-alpha-acetylmethadol.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Methadone; Methadyl Acetate; Morphine; Pentobarbital; Phencyclidine; Rats; Rats, Inbred Strains | 1984 |
Phencyclidine inhibition of cerebellar Purkinje neurons.
Topics: Animals; Flupenthixol; gamma-Aminobutyric Acid; Haloperidol; Hydroxydopamines; Male; Norepinephrine; Phencyclidine; Purkinje Cells; Rats | 1981 |
Ethanol intake increases during continuous administration of amphetamine and nicotine, but not several other drugs.
Topics: Alcohol Drinking; Amphetamine; Animals; Caffeine; Drinking Behavior; Drug Implants; Female; Haloperidol; Lysergic Acid Diethylamide; Mescaline; Nicotine; Phencyclidine; Rats; Secobarbital | 1983 |
Effects of phencyclidine on aggressive behavior in mice.
Topics: Aggression; Animals; Dose-Response Relationship, Drug; Drug Interactions; Female; Haloperidol; Humans; Male; Methysergide; Mice; Motor Activity; Phencyclidine; Social Behavior | 1982 |
Phencyclidine intoxication: assessment of possible antidotes.
Topics: Antidotes; Haloperidol; Humans; Meperidine; Phencyclidine; Physostigmine | 1982 |
Phencyclidine suppresses plasma prolactin levels.
Topics: Animals; Haloperidol; Male; Phencyclidine; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Time Factors | 1982 |
The effects of apomorphine and haldol on PCP induced behavioral and motor abnormalities in the rat.
Topics: Animals; Apomorphine; Behavior, Animal; Haloperidol; Humans; Male; Motor Activity; Phencyclidine; Psychoses, Substance-Induced; Rats; Receptors, Dopamine | 1980 |
The effect of phencyclidine on dopamine metabolism in the mouse brain.
Topics: 4-Butyrolactone; Animals; Brain; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Homovanillic Acid; Humans; Locomotion; Male; Methyltyrosines; Mice; Phencyclidine; Stereotyped Behavior; Tyrosine | 1981 |
Effects of dopaminergic drugs on phencyclidine-induced behavior in the rat.
Topics: Analysis of Variance; Animals; Apomorphine; Ataxia; Behavior, Animal; Corpus Striatum; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Motor Activity; Phencyclidine; Rats; Receptors, Dopamine; Stereotyped Behavior | 1981 |
Phencyclidine-induced depressions of cerebellar Purkinje neurons.
Topics: Animals; Electric Conductivity; Haloperidol; Ketamine; Male; Neurons; Phencyclidine; Purkinje Cells; Rats | 1980 |
The effect of phencyclidine on dopamine synthesis and metabolic in rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; 4-Butyrolactone; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Homovanillic Acid; Male; Phencyclidine; Rats | 1980 |
Effects of risperidone on phencyclidine-induced behaviors: comparison with haloperidol and ritanserin.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Frontal Lobe; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Isoxazoles; Locomotion; Male; Phencyclidine; Piperidines; Random Allocation; Rats; Rats, Wistar; Risperidone; Ritanserin; Schizophrenia; Serotonin; Stereotyped Behavior | 1994 |
Risperidone prevents the development of supersensitivity, but not tolerance, to phencyclidine in rats treated with subacute phencyclidine.
Topics: Animals; Antipsychotic Agents; Dizocilpine Maleate; Drug Tolerance; Haloperidol; Isoxazoles; Male; Methamphetamine; Motor Activity; Phencyclidine; Piperidines; Rats; Rats, Wistar; Receptors, Phencyclidine; Receptors, Serotonin; Risperidone; Ritanserin | 1995 |
The atypical antipsychotic, remoxipride, blocks phencyclidine-induced disruption of prepulse inhibition in the rat.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Phencyclidine; Raclopride; Rats; Rats, Sprague-Dawley; Reflex, Startle; Remoxipride; Salicylamides | 1994 |
Sigma-1 receptors modulate functional activity of rat splenocytes.
Topics: Animals; Concanavalin A; Haloperidol; Immune Tolerance; Lymphocyte Activation; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, sigma; Spleen | 1995 |
Phencyclidine- and dizocilpine-induced hyperlocomotion are differentially mediated.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Ergolines; Haloperidol; Male; Motor Activity; Phencyclidine; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Remoxipride; Salicylamides | 1994 |
PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Avoidance Learning; Cholinergic Agents; Dizocilpine Maleate; Dose-Response Relationship, Drug; Haloperidol; Learning; Male; Maze Learning; Memory; Memory, Short-Term; Mice; Morpholines; Phencyclidine; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma | 1994 |
Density of NMDA-coupled and uncoupled 1-[1-(2-[3H]thienyl) cyclohexyl]piperidine recognition sites in the brain and spinal cord: differential effects of NMDA agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; Haloperidol; Male; Mice; N-Methylaspartate; Phencyclidine; Spinal Cord; Tritium | 1994 |
(+)-[C-11]-cis-N-benzyl-normetazocine: a selective ligand for sigma receptors in vivo.
Topics: Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Cyclazocine; Haloperidol; Kinetics; Ligands; Male; Mice; Organ Specificity; Pentazocine; Phencyclidine; Piperidines; Receptors, sigma; Spiperone; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed | 1994 |
Lymphocytopenia and occupational exposures among pattern and model makers.
Topics: Adult; Automobiles; Case-Control Studies; Confidence Intervals; Dust; Epoxy Resins; Humans; Industry; Leukocyte Count; Lymphopenia; Male; Mass Screening; Middle Aged; Occupational Diseases; Occupational Exposure; Odds Ratio; Plastics; Prevalence; Risk Factors; Wood | 1994 |
MK-801 and phencyclidine act at phencyclidine sites that are not linked to N-methyl-D-aspartate activity to inhibit behavioral sensitization to kainate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Capsaicin; Dizocilpine Maleate; Haloperidol; Kainic Acid; Male; Mice; N-Methylaspartate; Nociceptors; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1993 |
FH-510, a potent and selective ligand for rat brain sigma recognition sites.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Carbazoles; Dopamine; Haloperidol; Male; Mice; Phenazocine; Phencyclidine; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma; Stereotyped Behavior | 1993 |
The effects of haloperidol and clozapine on PCP- and amphetamine-induced suppression of social behavior in the rat.
Topics: Aggression; Amphetamine; Animals; Clozapine; Haloperidol; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Social Behavior | 1994 |
Effect of phencyclidine on contraction of porcine coronary vessel strips.
Topics: Animals; Biological Assay; Coronary Vessels; Dextromethorphan; Dizocilpine Maleate; Haloperidol; In Vitro Techniques; Muscle, Smooth, Vascular; Myocardial Contraction; Phenazocine; Phencyclidine; Receptors, Phencyclidine; Receptors, sigma; Swine | 1993 |
Heat shock proteins used to show that haloperidol prevents neuronal injury produced by ketamine, MK801, and phencyclidine.
Topics: Animals; Biomarkers; Cell Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Gyrus Cinguli; Haloperidol; Heat-Shock Proteins; Ketamine; Neurons; Neurotoxins; Phencyclidine; Rats | 1993 |
Effect of repeated haloperidol administration on phencyclidine discrimination in rats.
Topics: Animals; Discrimination Learning; Discrimination, Psychological; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1995 |
Sigma receptor activation does not mediate fentanyl-induced attenuation of muscarinic coronary contraction.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Coronary Vessels; Cyclazocine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fentanyl; Guanidines; Haloperidol; Muscarine; Muscarinic Agonists; Narcotic Antagonists; Narcotics; Pentazocine; Phencyclidine; Piperidines; Potassium Channel Blockers; Receptors, Dopamine; Receptors, sigma; Signal Transduction; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Haloperidol prevents ketamine- and phencyclidine-induced HSP70 protein expression but not microglial activation.
Topics: Animals; Female; Gene Expression; Haloperidol; HSP70 Heat-Shock Proteins; Immunohistochemistry; Ketamine; Microglia; Phencyclidine; Rats; Rats, Sprague-Dawley | 1996 |
Involvement of dopamine D1 receptors in phencyclidine-induced behavioral stimulation in rats.
Topics: Animals; Behavior, Animal; Benzazepines; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Ketanserin; Locomotion; Male; Phencyclidine; Rats; Rats, Wistar; Receptors, Dopamine D1 | 1995 |
Ethanol-induced inhibition of [3H]thienylcyclohexylpiperidine (TCP) binding to NMDA receptors in brain synaptic membranes and to a purified protein complex.
Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine Antagonists; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Haloperidol; Illicit Drugs; Kinetics; Male; Membrane Proteins; N-Methylaspartate; Phencyclidine; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Spermidine; Synaptic Membranes; Tritium | 1996 |
Phencyclidine-induced increases in striatal neuron firing in behaving rats: reversal by haloperidol and clozapine.
Topics: Animals; Behavior, Animal; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Haloperidol; Locomotion; Male; Membrane Potentials; Neurons; Phencyclidine; Rats; Rats, Sprague-Dawley | 1995 |
Occupational dermatoses from exposure to epoxy resin compounds in a ski factory.
Topics: Adhesives; Cobalt; Dermatitis, Allergic Contact; Dermatitis, Irritant; Dermatitis, Occupational; Dust; Epoxy Resins; Ethylene Glycols; Female; Finland; Formaldehyde; Glass; Humans; Lacquer; Male; Methyl Ethers; Occupational Exposure; Patch Tests; Skiing | 1996 |
Non-aminergic effects of amphetamine on the NMDA receptor in primary cultured cortical cells.
Topics: Amphetamines; Animals; Calcium; Cell Membrane; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Haloperidol; Phencyclidine; Protein Kinases; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1996 |
Seroquel restores sensorimotor gating in phencyclidine-treated rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiazepines; Haloperidol; Male; Phencyclidine; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone | 1996 |
Characterization of haloperidol and trifluperidol as subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonists using [3H]TCP and [3H]ifenprodil binding in rat brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Female; Haloperidol; Illicit Drugs; Kinetics; Oocytes; Phencyclidine; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Trifluperidol; Xenopus | 1997 |
Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice.
Topics: Animals; Benzodiazepines; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Motor Activity; Olanzapine; Phencyclidine; Pirenzepine; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT3; Serotonin Antagonists | 1997 |
A time-activity baseline to measure pharmacological and non-pharmacological manipulations of PCP-induced activity in mice.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Modulators; Haloperidol; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentobarbital; Phencyclidine; Time Factors | 1997 |
Differential effects of the strychnine-insensitive glycine site antagonist (+)-HA-966 on the hyperactivity and the disruption of prepulse inhibition induced by phencyclidine in rats.
Topics: Animals; Antipsychotic Agents; Apomorphine; Dopamine Agonists; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Hyperkinesis; Male; Motor Activity; Phencyclidine; Pyrrolidinones; Rats; Rats, Wistar; Reflex, Startle; Strychnine | 1998 |
A test of the predictive validity of animal models of schizophrenia based on phencyclidine and D-amphetamine.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dextroamphetamine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Male; Motor Activity; Phencyclidine; Predictive Value of Tests; Rats; Rats, Wistar; Schizophrenia; Social Behavior; Stereotyped Behavior | 1998 |
Effects of phencyclidine (PCP) and (+)MK-801 on sensorimotor gating in CD-1 mice.
Topics: Acoustic Stimulation; Animals; Apomorphine; Clozapine; Dextroamphetamine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Rats; Receptors, sigma; Reflex, Startle; Species Specificity | 1998 |
Chronic treatment with haloperidol diminishes the phencyclidine-induced sensorimotor gating deficit in rats.
Topics: Animals; Antipsychotic Agents; Drug Antagonism; Excitatory Amino Acid Antagonists; Haloperidol; Male; Phencyclidine; Rats; Rats, Wistar; Reflex, Startle; Time Factors | 1998 |
M100907 and clozapine, but not haloperidol or raclopride, prevent phencyclidine-induced blockade of NMDA responses in pyramidal neurons of the rat medial prefrontal cortical slice.
Topics: Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Antagonists; Fluorobenzenes; Haloperidol; In Vitro Techniques; Male; Patch-Clamp Techniques; Phencyclidine; Piperidines; Prefrontal Cortex; Pyramidal Cells; Raclopride; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Salicylamides; Serotonin Antagonists | 1998 |
Subchronic phencyclidine administration increases mesolimbic dopaminergic system responsivity and augments stress- and psychostimulant-induced hyperlocomotion.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Brain; Dextroamphetamine; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Drug Administration Schedule; Haloperidol; Limbic System; Male; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Stress, Psychological; Time Factors | 1998 |
Characterization of the phencyclidine-induced increase in prefrontal cortical dopamine metabolism in the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alanine; Animals; Corpus Striatum; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Hallucinogens; Haloperidol; Injections, Intraventricular; Male; N-Methylaspartate; Neurons, Afferent; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar | 1998 |
Haloperidol potentiates the EEG slowing of MK-801 despite blocking its motor effects: implications for the PCP model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Electromyography; Excitatory Amino Acid Antagonists; Hallucinogens; Haloperidol; Male; Motor Activity; Phencyclidine; Rats; Rats, Sprague-Dawley; Schizophrenia; Sleep, REM | 1998 |
Psychotomimetic-induction of tissue plasminogen activator mRNA in corticostriatal neurons in rat brain.
Topics: Animals; Benzazepines; Central Nervous System Agents; Cocaine; Corpus Striatum; Dopamine Antagonists; Haloperidol; In Situ Hybridization; Male; Methamphetamine; Neurons; Nomifensine; Phencyclidine; Rats; Rats, Wistar; RNA Probes; RNA, Messenger; Tissue Plasminogen Activator | 1998 |
Dopamine D4 receptor antagonist reversal of subchronic phencyclidine-induced object retrieval/detour deficits in monkeys.
Topics: Animals; Chlorocebus aethiops; Cognition Disorders; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Female; Hallucinogens; Haloperidol; Imidazoles; Male; Phencyclidine; Prefrontal Cortex; Pyrimidines; Receptors, Dopamine D4 | 1999 |
Clozapine, but not haloperidol, prevents the functional hyperactivity of N-methyl-D-aspartate receptors in rat cortical neurons induced by subchronic administration of phencyclidine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Binding of [3H]desglycinyl remacemide to rat brain membranes: association with the benzomorphan attachment site of the N-methyl-D-aspartic acid receptor channel.
Topics: Animals; Antipsychotic Agents; Benzomorphans; Binding Sites; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Haloperidol; Male; Membrane Proteins; Neurons; Phenazocine; Phencyclidine; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions; Tritium | 1999 |
Leukoderma following occupational allergic contact dermatitis.
Topics: Adult; Benzocaine; Dermatitis, Allergic Contact; Dermatitis, Occupational; Dust; Epoxy Resins; Humans; Hypopigmentation; Male; Middle Aged; Patch Tests; Resins, Plant; Wood | 1999 |
Mice with reduced NMDA receptor expression display behaviors related to schizophrenia.
Topics: Animals; Antipsychotic Agents; Antisocial Personality Disorder; Behavior, Animal; Calcium Signaling; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Haloperidol; Male; Mice; Mice, Knockout; Motor Activity; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenic Psychology; Serotonin Antagonists; Sexual Behavior, Animal; Social Behavior; Stereotyped Behavior | 1999 |
Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for sigma receptors.
Topics: Amisulpride; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Dopamine Agonists; Free Radical Scavengers; Guinea Pigs; Haloperidol; Head Movements; Male; Mice; Phenazocine; Phencyclidine; Piperazines; Pyrrolidines; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, sigma; Risperidone; Serotonin; Serotonin Antagonists; Stereotyped Behavior; Sulpiride; Tartrates | 1999 |
Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Corpus Striatum; Gene Expression Regulation; Gyrus Cinguli; Haloperidol; HSP70 Heat-Shock Proteins; Male; Nucleus Accumbens; Olanzapine; Phencyclidine; Pirenzepine; Prefrontal Cortex; Rats; Rats, Wistar; Risperidone; RNA, Messenger | 1999 |
Differential effects of haloperidol on phencyclidine-induced reduction in substance P contents in rat brain regions.
Topics: Animals; Brain; Corpus Striatum; Drug Interactions; Haloperidol; Limbic System; Male; Phencyclidine; Prefrontal Cortex; Prosencephalon; Rats; Rats, Wistar; Substance P; Substantia Nigra; Ventral Tegmental Area | 2000 |
Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Cytoskeletal Proteins; Gene Expression; Haloperidol; Male; Nerve Tissue Proteins; Olanzapine; Phencyclidine; Pirenzepine; Rats; Rats, Wistar; Risperidone; RNA, Messenger; Tissue Distribution | 2000 |
Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory.
Topics: Animals; Antipsychotic Agents; Benzazepines; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Interneurons; Male; Memory Disorders; Memory, Short-Term; Phencyclidine; Rats; Risperidone; Schizophrenia; Spiperone | 2000 |
"Early" and "late" effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits.
Topics: Animals; Antipsychotic Agents; Apomorphine; Dopamine Agonists; Drug Implants; Excitatory Amino Acid Antagonists; Haloperidol; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Reflex, Startle | 2000 |
Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Hallucinogens; Haloperidol; Male; Mice; Models, Animal; Phencyclidine; Schizophrenia; Social Behavior; Substance Withdrawal Syndrome | 2001 |
Atypical antipsychotic effects of quetiapine fumarate in animal models.
Topics: Amphetamine; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Disease Models, Animal; Female; Haloperidol; Immobilization; Male; Mice; Phencyclidine; Rats; Rats, Wistar; Schizophrenia; Schizophrenia, Paranoid | 2000 |
Differential effects of amphetamine and phencyclidine on the expression of growth-associated protein GAP-43.
Topics: Amphetamine; Animals; Biomarkers; Brain; Disease Models, Animal; Dopamine Agents; Dopamine Antagonists; Drug Administration Schedule; Excitatory Amino Acid Antagonists; GAP-43 Protein; Haloperidol; Male; Neostriatum; Neurons; Phencyclidine; Psychoses, Substance-Induced; Psychotic Disorders; Rats; Rats, Inbred Strains; RNA, Messenger | 2001 |
Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex.
Topics: Animals; Clozapine; Fluorobenzenes; Glutamic Acid; Haloperidol; Male; Microdialysis; Phencyclidine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 2001 |
Phencyclidine supersensitivity in rats with neonatal dopamine loss.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Animals, Newborn; Antipsychotic Agents; Benzazepines; Benzodiazepines; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Haloperidol; Ketamine; Male; Motor Activity; Olanzapine; Oxidopamine; Phencyclidine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Sex Factors | 2002 |
Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chlorpromazine; Clozapine; Haloperidol; Ion Channels; Male; Olanzapine; Phencyclidine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2002 |
Effects of haloperidol and clozapine on neuropeptide Y-like immunoreactivity in the nucleus accumbens and striatum of rats pretreated with psychostimulants.
Topics: Amphetamine; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Hallucinogens; Haloperidol; Immunohistochemistry; Male; Motor Activity; Neostriatum; Neuropeptide Y; Nucleus Accumbens; Phencyclidine; Rats; Rats, Wistar; Stereotyped Behavior | 2003 |
Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Olanzapine; Patch-Clamp Techniques; Phencyclidine; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2003 |
The atypical antipsychotic ziprasidone, but not haloperidol, improves phencyclidine-induced cognitive deficits in a reversal learning task in the rat.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Cognition Disorders; Excitatory Amino Acid Antagonists; Female; Haloperidol; Injections, Intraperitoneal; Phencyclidine; Piperazines; Rats; Reversal Learning; Social Isolation; Thiazoles | 2003 |
Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine.
Topics: Animals; Blotting, Western; Carboxypeptidases; Clozapine; Dopamine Antagonists; Drug Administration Schedule; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Haloperidol; Hippocampus; Male; Phencyclidine; Prefrontal Cortex; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 2003 |
Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Behavior, Animal; Cebus; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesias; Excitatory Amino Acid Antagonists; Female; Haloperidol; Neural Inhibition; Phencyclidine; Reflex, Startle; Schizophrenia | 2003 |
Effects of NRA0045, a novel potent antagonist at dopamine D4, 5-HT2A, and alpha1 adrenaline receptors, and NRA0160, a selective D4 receptor antagonist, on phencyclidine-induced behavior and glutamate release in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Chromatography, High Pressure Liquid; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Haloperidol; Male; Microdialysis; Motor Activity; Phencyclidine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Stereotyped Behavior; Thiazoles; Time Factors | 2003 |
A health hazard associated with epoxy resin-concrete dust.
Topics: Disease; Dura Mater; Dust; Epoxy Resins; Hazardous Substances; Resins, Synthetic; Respiration Disorders; Respiratory System; Respiratory Tract Diseases; Xylenes | 1961 |
ANAESTHESIA FOR UNDER-DOCTORED AREAS. A TRIAL OF PHENCYCLIDINE IN NIGERIA.
Topics: Anesthesia; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics; Atropine; Child; Chlorpromazine; Female; Haloperidol; Humans; Meperidine; Nigeria; Obstetrics; Phencyclidine; Preanesthetic Medication; Pregnancy; Rural Health | 1964 |
Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms.
Topics: Animals; Antipsychotic Agents; Central Nervous System Stimulants; Dextroamphetamine; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Habituation, Psychophysiologic; Hallucinogens; Haloperidol; Male; Mice; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Phencyclidine; Reflex, Startle | 2004 |
Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic alpha7 receptors.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apomorphine; Central Nervous System; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Rats; Rats, Wistar; Receptors, Nicotinic; Reflex, Startle | 2004 |
Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat.
Topics: Animals; Antimanic Agents; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Hallucinogens; Haloperidol; Lamotrigine; Learning Disabilities; Phencyclidine; Rats; Reversal Learning; Triazines | 2005 |
Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists.
Topics: Animals; Benzazepines; Cell Count; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Gene Expression; Genes, fos; Haloperidol; In Situ Hybridization; Mice; Mice, Knockout; Motor Activity; Phencyclidine; RNA, Messenger; Time Factors; Tyrosine 3-Monooxygenase | 2005 |
SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Clozapine; Dextroamphetamine; Dioxanes; Discrimination, Psychological; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Imipramine; Injections, Intraperitoneal; Male; Phencyclidine; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Recognition, Psychology; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Social Behavior; Tacrine; Tropanes | 2005 |
Effects of novel antipsychotics with mixed D(2) antagonist/5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Dioxanes; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Interpersonal Relations; Male; Phencyclidine; Piperazines; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Remoxipride; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Tropanes | 2005 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition Disorders; Exploratory Behavior; Hallucinogens; Haloperidol; Male; Mice; Mice, Inbred ICR; Phencyclidine; Time Factors | 2005 |
Clozapine and olanzapine, but not haloperidol, suppress serotonin efflux in the medial prefrontal cortex elicited by phencyclidine and ketamine.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzodiazepines; Brain Chemistry; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Ketamine; Male; Microdialysis; Olanzapine; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin; Time Factors | 2006 |
Selective increases in the cytokine, TNFalpha, in the prefrontal cortex of PCP-treated rats and human schizophrenic subjects: influence of antipsychotic drugs.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Clozapine; Cytokines; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Gene Expression; Haloperidol; Humans; Immunohistochemistry; Male; Middle Aged; Phencyclidine; Prefrontal Cortex; Rats; Rats, Long-Evans; Reverse Transcriptase Polymerase Chain Reaction; RNA; Schizophrenia; Tumor Necrosis Factor-alpha | 2006 |
Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Central Nervous System Stimulants; Corpus Striatum; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Dendritic Spines; Dextroamphetamine; Drug Synergism; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Haloperidol; Mice; Mice, Knockout; Motor Activity; Papaverine; Phencyclidine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Rats | 2006 |
Clozapine but not haloperidol treatment reverses sub-chronic phencyclidine-induced disruption of conditional discrimination performance.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Cognition Disorders; Conditioning, Operant; Discrimination Learning; Dopamine; Excitatory Amino Acid Antagonists; Goals; Haloperidol; Male; Phencyclidine; Prefrontal Cortex; Rats | 2006 |
Role of the simultaneous enhancement of NMDA and dopamine D1 receptor-mediated neurotransmission in the effects of clozapine on phencyclidine-induced acute increases in glutamate levels in the rat medial prefrontal cortex.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Haloperidol; Humans; Male; Microdialysis; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2006 |
The atypical antipsychotic, aripiprazole, blocks phencyclidine-induced disruption of prepulse inhibition in mice.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Mice; Neural Inhibition; Olanzapine; Phencyclidine; Piperazines; Quinolones; Receptors, Dopamine D2; Reflex, Startle; Schizophrenia | 2007 |
Clozapine, SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Clozapine; Cognition; Cognition Disorders; Conditioning, Classical; Conditioning, Operant; Discrimination Learning; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Flupenthixol; Haloperidol; Male; Phencyclidine; Predictive Value of Tests; Rats; Reproducibility of Results; Serotonin Antagonists | 2007 |
Differential effects of acute and subchronic clozapine and haloperidol on phencyclidine-induced decreases in voluntary sucrose consumption in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Eating; Hallucinogens; Haloperidol; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Reward; Schizophrenia; Sucrose | 2007 |
Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Male; Maze Learning; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenic Psychology | 2007 |
Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats.
Topics: Animals; Antipsychotic Agents; Attention; Benzodiazepines; Clozapine; Cognition Disorders; Dibenzothiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Impulsive Behavior; Male; Olanzapine; Phencyclidine; Quetiapine Fumarate; Rats; Rats, Wistar; Reaction Time; Risperidone; Schizophrenia | 2007 |
Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine.
Topics: Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Antagonists; Haloperidol; Histocytochemistry; In Situ Hybridization; Male; Patch-Clamp Techniques; Phencyclidine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2007 |
Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Haloperidol; Matched-Pair Analysis; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Schizophrenia; Schizophrenic Psychology; Social Behavior; Social Behavior Disorders; Thiazoles | 2008 |
Repeated low dose of phencyclidine administration impairs spatial learning in mice: blockade by clozapine but not by haloperidol.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Haloperidol; Learning Disabilities; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Phencyclidine; Retention, Psychology; Rotarod Performance Test; Spatial Behavior; Time Factors | 2008 |
A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats.
Topics: Animals; Antipsychotic Agents; Attention; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Habituation, Psychophysiologic; Haloperidol; Phencyclidine; Pilot Projects; Rats; Rats, Inbred Strains; Risperidone; Set, Psychology; Sex Factors; Statistics, Nonparametric | 2008 |
Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat--a back translational study.
Topics: Animals; Antipsychotic Agents; Attention; Benzhydryl Compounds; Central Nervous System Stimulants; Cognition Disorders; Conditioning, Operant; Discrimination, Psychological; Excitatory Amino Acid Antagonists; Haloperidol; Imidazoles; Indoles; Male; Modafinil; Phencyclidine; Psychomotor Performance; Rats; Risperidone; Schizophrenic Psychology | 2009 |
Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Exploratory Behavior; Haloperidol; Male; Memory Disorders; Mice; Mice, Inbred ICR; Motor Activity; Phencyclidine; Piperazines; Quinolones; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D1; Recognition, Psychology | 2009 |
Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine.
Topics: Amisulpride; Amphetamine; Animals; Antipsychotic Agents; Basal Ganglia; Behavior, Animal; Blood-Brain Barrier; Brain; Clozapine; Conditioning, Psychological; Haloperidol; Male; Models, Animal; Motor Activity; Phencyclidine; Prefrontal Cortex; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Risperidone; Sulpiride | 2008 |
Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibition on amphetamine-induced hyperlocomotion: relevance to animal models of antipsychotic drugs.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Clozapine; Disease Models, Animal; Haloperidol; Hyperkinesis; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
NMDA antagonist and antipsychotic actions in cortico-subcortical circuits.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Clozapine; Haloperidol; Male; Neural Pathways; Phencyclidine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Thalamic Nuclei | 2008 |
Behavioral changes in G72/G30 transgenic mice.
Topics: Animals; Behavior, Animal; Brain; Carrier Proteins; Compulsive Behavior; Dopamine Antagonists; Haloperidol; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Motor Activity; Motor Skills Disorders; Olfaction Disorders; Phencyclidine; Proteins; RNA, Messenger; Sensory Gating | 2009 |
Developmentally regulated and thalamus-selective induction of leiomodin2 gene by a schizophrenomimetic, phencyclidine, in the rat.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Cytoskeletal Proteins; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Gene Expression Profiling; Gene Expression Regulation, Developmental; Hallucinogens; Haloperidol; Male; Microfilament Proteins; Muscle Proteins; Myocardium; Oligonucleotide Array Sequence Analysis; Phencyclidine; Rats; Rats, Wistar; RNA, Messenger; Thalamus; Time Factors; Tropomodulin | 2009 |
Antipsychotic-like effects of the N-methyl-D-aspartate receptor modulator neboglamine: an immunohistochemical and behavioural study in the rat.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Immunohistochemistry; Male; Motor Activity; Pentanoic Acids; Phencyclidine; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine | 2010 |
Modulation of prepulse inhibition and stereotypies in rodents: no evidence for antipsychotic-like properties of histamine H3-receptor inverse agonists.
Topics: Animals; Antipsychotic Agents; Apomorphine; Benzofurans; Dizocilpine Maleate; Drug Inverse Agonism; Haloperidol; Histamine Antagonists; Imidazoles; Inhibition, Psychological; Male; Methamphetamine; Mice; Phencyclidine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Stereotyped Behavior | 2010 |
Erythropoietin reverses the attentional set-shifting impairment in a rodent schizophrenia disease-like model.
Topics: Animals; Antipsychotic Agents; Attention; Behavior, Animal; Benzhydryl Compounds; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epoetin Alfa; Erythropoietin; Executive Function; Haloperidol; Male; Modafinil; Neuropsychological Tests; Phencyclidine; Rats; Recombinant Proteins; Reward; Schizophrenia; Schizophrenic Psychology | 2010 |
Time course of the attenuation effect of repeated antipsychotic treatment on prepulse inhibition disruption induced by repeated phencyclidine treatment.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Dibenzothiazepines; Drug Interactions; Hallucinogens; Haloperidol; Humans; Male; Models, Animal; Motor Activity; Phencyclidine; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone | 2011 |
Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.
Topics: Animals; Behavior, Animal; Benzodiazepines; Blotting, Western; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Motor Activity; Olanzapine; Phencyclidine; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Stereotyped Behavior; Up-Regulation | 2011 |
Contextual and behavioral control of antipsychotic sensitization induced by haloperidol and olanzapine.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Conditioning, Psychological; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Olanzapine; Phencyclidine; Rats; Rats, Sprague-Dawley | 2012 |
Neural basis of the potentiated inhibition of repeated haloperidol and clozapine treatment on the phencyclidine-induced hyperlocomotion.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Brain; Clozapine; Haloperidol; Hyperkinesis; Male; Motor Activity; Neurons; Phencyclidine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2012 |
A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Attention; Benzodiazepines; Body Weight; Cocaine; Conditioning, Operant; Depression; Disease Models, Animal; Dopamine Uptake Inhibitors; Electroencephalography; Hallucinogens; Haloperidol; Humans; Macaca fascicularis; Magnetic Resonance Imaging; Male; Mental Recall; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microinjections; Motor Activity; Mutation; Olanzapine; Oocytes; Oxazoles; Phencyclidine; Phenethylamines; Protein Binding; Pyrrolidinones; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reinforcement, Psychology; Schizophrenia; Swimming; Telemetry; Tritium; Xenopus | 2013 |
Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Isoindoles; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Piperidines; Pyridines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Thiazoles; Urea | 2012 |
Airborne allergic contact dermatitis in a parquet fitter.
Topics: Air Pollutants, Occupational; Construction Industry; Dermatitis, Allergic Contact; Dermatitis, Occupational; Dust; Epoxy Resins; Humans; Male; Middle Aged; Patch Tests; Recurrence | 2012 |
Use of haloperidol in PCP-intoxicated individuals.
Topics: Adult; Electrocardiography; Female; Haloperidol; Humans; Male; Middle Aged; Phencyclidine; Psychomotor Agitation; Retrospective Studies | 2012 |
Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor.
Topics: Animals; Antipsychotic Agents; Benzazepines; Butyric Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Clozapine; Dopamine Antagonists; Epigenesis, Genetic; Exploratory Behavior; Hallucinogens; Haloperidol; Histamine Antagonists; Histone Deacetylases; Histones; Male; Memory Disorders; Mice; Mice, Inbred ICR; Phencyclidine; Phencyclidine Abuse; Prefrontal Cortex; Receptors, Dopamine D1 | 2014 |
Effect of environmental cues on the behavioral efficacy of haloperidol, olanzapine, and clozapine in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Cues; Drug Tolerance; Environment; Excitatory Amino Acid Antagonists; Haloperidol; Housing, Animal; Hyperkinesis; Male; Motor Activity; Olanzapine; Phencyclidine; Random Allocation; Rats, Sprague-Dawley | 2014 |
Combined serotonin (5-HT)1A agonism, 5-HT(2A) and dopamine D₂ receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Haloperidol; Isoindoles; Memory Disorders; Phencyclidine; Piperazines; Piperidines; Pyrimidines; Random Allocation; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Urea | 2015 |
Temporal and spatial transcriptional fingerprints by antipsychotic or propsychotic drugs in mouse brain.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brain; Dizocilpine Maleate; Gene Expression Profiling; Gene Expression Regulation; Hallucinogens; Haloperidol; Methamphetamine; Mice; Olanzapine; Phencyclidine; Receptors, Dopamine D2 | 2015 |
Neuropharmacology of light-induced locomotor activation.
Topics: Animals; Dopamine Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Haloperidol; Indoles; Ketamine; Light; Male; Motor Activity; Naphthyridines; Phencyclidine; Photic Stimulation; Piperazines; Piperidines; Pyridines; Quinpirole; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Ritanserin; Serotonin Antagonists | 2015 |
Comparative pharmacological evaluation of the cathinone derivatives, mephedrone and methedrone, in mice.
Topics: Animals; Anti-Anxiety Agents; Body Temperature; Brain; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Hallucinogens; Haloperidol; Hindlimb Suspension; Locomotion; Maze Learning; Methamphetamine; Mice; Mice, Inbred C57BL; Neurotransmitter Agents; Pain Measurement; Phencyclidine; Propiophenones; Stereotyped Behavior | 2015 |
Dopamine D3 receptor antagonism contributes to blonanserin-induced cortical dopamine and acetylcholine efflux and cognitive improvement.
Topics: Acetylcholine; Animals; Benzopyrans; Brain Chemistry; Cerebral Cortex; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Fluorenes; Haloperidol; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Oxazines; Phencyclidine; Piperazines; Piperidines; Rats, Long-Evans; Receptors, Dopamine D3 | 2015 |
Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey.
Topics: Acoustic Stimulation; Animals; Auditory Perception; Bromocriptine; Evoked Potentials, Auditory; Female; Haloperidol; Macaca fascicularis; Phencyclidine; Prefrontal Cortex; Sensory Gating; Temporal Lobe | 2016 |
Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice.
Topics: Animals; Antioxidants; Behavior, Animal; Cell Nucleus; Clozapine; DNA; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glutathione Reductase; Haloperidol; Lipid Peroxidation; Male; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidation-Reduction; Phencyclidine; Prefrontal Cortex; Reactive Oxygen Species; RNA, Messenger; Social Behavior; Superoxide Dismutase; Time Factors; Transcription Factor RelA | 2017 |
Time-dependent sensitization of antipsychotic effect in adolescent male and female rats.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Female; Haloperidol; Male; Motor Activity; Olanzapine; Phencyclidine; Random Allocation; Rats, Sprague-Dawley; Sex Characteristics; Time Factors | 2017 |
Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine.
Topics: Animals; Antipsychotic Agents; Bone and Bones; Bone Density; Clozapine; Corticosterone; Female; Haloperidol; Interleukin-6; Male; Phencyclidine; Rats, Wistar; Schizophrenia; Sex Characteristics; Tumor Necrosis Factor-alpha | 2017 |
Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions.
Topics: Amphetamine; Animals; Behavior, Animal; beta-Arrestins; Cocaine; Dopamine; Female; Genetic Vectors; Haloperidol; Heterotrimeric GTP-Binding Proteins; Male; Mice; Mice, Knockout; Mice, Transgenic; Phencyclidine; Receptors, Dopamine D2; Signal Transduction | 2018 |
D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice.
Topics: Animals; Benzazepines; Clozapine; Dopamine D2 Receptor Antagonists; Haloperidol; Hippocampus; Male; Mice; Mice, Transgenic; MicroRNAs; Motor Activity; Neuregulin-1; Phencyclidine; Prefrontal Cortex; Primary Cell Culture; Quinpirole; Receptors, Dopamine D2; Salicylamides | 2019 |
Atypical, but Not Typical, Antipsychotic Drugs Reduce Hypersynchronized Prefrontal-Hippocampal Circuits during Psychosis-Like States in Mice: Contribution of 5-HT2A and 5-HT1A Receptors.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Hippocampus; Mice; Phencyclidine; Prefrontal Cortex; Psychotic Disorders; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Risperidone; Serotonin Antagonists | 2022 |
Lu AF35700 reverses the phencyclidine-induced disruption of thalamo-cortical activity by blocking dopamine D
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Dopamine Antagonists; Haloperidol; Phencyclidine; Rats; Receptors, Dopamine D1 | 2023 |