haloperidol has been researched along with pentazocine in 92 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (16.30) | 18.7374 |
| 1990's | 49 (53.26) | 18.2507 |
| 2000's | 14 (15.22) | 29.6817 |
| 2010's | 7 (7.61) | 24.3611 |
| 2020's | 7 (7.61) | 2.80 |
| Authors | Studies |
|---|---|
| Mamolo, MG; Menegazzi, R; Romano, M; Zampieri, D | 1 |
| Che, T; Kalinin, DV; Loser, K; Mykicki, N; Schepmann, D; Ständer, S; Tangherlini, G; Wünsch, B | 1 |
| Qin, W; Tian, S; Wold, EA; Xu, Q; Ye, N; Zhen, XC; Zhou, J | 1 |
| Börgel, F; Catapano, CV; Civenni, G; Friedland, K; Holtschulte, C; Humpf, HU; Kopp, N; Laurini, E; Lehmkuhl, K; Pricl, S; Schepmann, D; Wünsch, B | 1 |
| Peng, Y; Welsh, WJ; Zhang, Q | 1 |
| Amata, E; Artacho-Cordón, A; Barbaraci, C; Cobos, EJ; Dichiara, M; Gómez-Guzmán, M; González-Cano, R; Marrazzo, A; Pasquinucci, L; Rodríguez-Gómez, I; Santos-Caballero, M; Turnaturi, R | 1 |
| Aiello, D; Diana, P; Jonas, H; Schepmann, D; Wünsch, B | 1 |
| Bechthold, E; Daniliuc, C; Ritter, N; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B | 1 |
| Amata, E; Dichiara, M; Fortuna, S; Mamolo, MG; Marrazzo, A; Pasquinucci, L; Romano, M; Turnaturi, R; Zampieri, D | 1 |
| Ahtee, L; Kääriäinen, I | 1 |
| Benveniste, D; Risbo, A | 1 |
| Appel, JB; Hernandez, LL; Holohean, AM | 1 |
| DeHaven-Hudkins, DL; Fleissner, LC | 1 |
| DeHaven-Hudkins, DL; Fleissner, LC; Ford-Rice, FY | 1 |
| Chavkin, C; Connor, MA | 1 |
| Codd, EE; Shank, RP | 1 |
| Pechnick, RN; Vargas, HM | 1 |
| Kizu, A | 1 |
| Brent, PJ | 1 |
| Kizu, A; Miyagishi, T; Yoshida, Y | 1 |
| Connick, JH; Fox, PK; France, L; Hanlon, GM; Nicholson, CD | 1 |
| Bowen, WD; Moses, EL; Tolentino, PJ; Walker, JM | 1 |
| Bowen, WD; Hellewell, SB | 1 |
| Klein, M; Musacchio, JM; Paturzo, JJ | 1 |
| Duffy, O; Junien, JL; Martin, B; Pascaud, X; Roman, FJ; Vauche, D | 1 |
| Su, TP; Vaupel, DB | 1 |
| Carranza-Acevedo, J; Estrada-Robles, U | 1 |
| Aochi, O | 1 |
| Fujita, T; Miyazaki, M | 1 |
| Brown, AS | 2 |
| Allaria, B; Calligari, G; Decio, B; Scaglione, V | 1 |
| Foong, FW; Satoh, M | 1 |
| Sakakibara, S | 1 |
| Kleinberg, ML; Latiolais, CJ; Stauffer, GL | 1 |
| Deben, SE; Gonzalez-Alvear, GM; Thompson-Montgomery, D; Werling, LL | 1 |
| Childers, SR; Mach, RH; Smith, CR | 1 |
| Brent, PJ; Dunkley, PR; Haynes, H; Jarvie, PE; Mudge, L; Sim, AT | 1 |
| Appleyard, SM; Chavkin, C; Connor, M; Patterson, TA | 1 |
| DeCoster, MA; Klette, KL; Knight, ES; Tortella, FC | 1 |
| Bowen, WD; John, CS; Vilner, BJ | 1 |
| Bowen, WD; Bruce, A; Feinstein, G; Hellewell, SB; Orringer, J; Williams, W | 1 |
| Starr, JB; Werling, LL | 1 |
| Chien, CC; Pasternak, GW | 3 |
| Barg, J; Eilam, Y; Ela, C; Hasin, Y; Vogel, Z | 1 |
| Nishikawa, T; Shirayama, Y; Takahashi, K | 1 |
| Dannals, RF; Mathews, WB; Musachio, JL; Ravert, HT; Scheffel, U; Stathis, M | 1 |
| Bergeron, R; de Montigny, C; Debonnel, G; Gronier, B; Monnet, FP | 1 |
| Dompert, WU; Glaser, T; Sommermeyer, H | 1 |
| Basile, AS; DeCosta, B; Paul, IA | 1 |
| Bergeron, R; Bouchard, P; de Montigny, C; Debonnel, G; Junien, JL; Monnet, F; Quirion, R; Roman, F | 1 |
| Brum, JM; Estafanous, FG; Murray, PA; Schubert, A; Tsuchida, H | 1 |
| Barfknecht, CF; Schoenwald, RD; Shirolkar, S; Xia, E | 1 |
| Eilam, Y; Ela, C; Hasin, Y | 1 |
| Kobayashi, T; Matsuno, K; Mita, S | 1 |
| Bowen, WD; De Costa, BR; Matsumoto, RR; Patrick, SL; Rice, KC; Truong, DD; Vo, VN; Walker, JM; Zambon, AC | 1 |
| Bowen, WD; Torrence-Campbell, C | 1 |
| Bowen, WD; de Costa, BR; Monnet, FP | 1 |
| Baine, Y; Daubert, JD; DeHaven-Hudkins, DL; Sawutz, DG; Tiberio, L | 1 |
| Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM | 1 |
| Frank, AR; Gonzalez-Alvear, GM; Weatherspoon, JK; Werling, LL | 1 |
| Ha, BK; Saini, P; Whitlock, BB; Wolfe, SA | 1 |
| Bergeron, R; de Montigny, C; Debonnel, G | 1 |
| Fang, H; Helmeste, DM; Li, M; Tang, SW | 1 |
| Maurice, T; Privat, A; Su, TP | 1 |
| Fei, YJ; Ganapathy, V; Huang, W; Leibach, FH; Li, HW; Seth, P | 1 |
| Christie, MJ; Ingram, SL; Kassiou, M; Nguyen, VH | 1 |
| Ganapathy, ME; Ganapathy, V; Huang, W; Leibach, FH; Prasad, PD; Seth, P | 1 |
| Baulieu, EE; Collin, T; Denavit-Saubié, M; Monnet, FP; Morin-Surun, MP | 1 |
| Kamei, J | 1 |
| Donald, A; Kassiou, M; Mardon, K | 1 |
| Hide, I; Ichimoto, H; Inoue, A; Nakata, Y; Shoji, H; Sugita, S | 1 |
| Hong, W; Werling, LL | 2 |
| Horikomi, K; Karasawa, J; Nukada, T; Okuyama, S; Sagi, N; Sora, I; Takahashi, S; Yamamoto, H; Yamamoto, T | 1 |
| Mei, J; Pasternak, GW | 1 |
| Cuevas, J; Zhang, H | 1 |
| Abate, C; Berardi, F; Colabufo, NA; Contino, M; Niso, M; Perrone, R; Tortorella, V | 1 |
| Hong, W; Nuwayhid, SJ; Werling, LL | 1 |
| Allmon, RL; Gustafson, JL; Lever, JR; Lever, SZ; Xu, R | 1 |
| Baeyens, JM; Cobos, EJ; del Pozo, E | 1 |
| Akhter, N; Kinuya, S; Mori, H; Nakajima, K; Ogawa, K; Shiba, K | 1 |
| Chen, S; Lee, IT; Schetz, JA | 1 |
| Jackson, MB; Johannessen, M; Ramachandran, S; Ramos-Serrano, A; Riemer, L; Ruoho, AE | 1 |
| Baeyens, JM; Cendán, CM; Cobos, EJ; Del Pozo, E; Entrena, JM; Nieto, FR | 1 |
| Balasuriya, D; Borgese, F; Crottès, D; Edwardson, JM; Soriani, O; Stewart, AP | 1 |
| Chu, UB; Fox, BG; Gromek, KA; LaPointe, LM; Meddaugh, HR; Primm, JG; Ruoho, AE; Senes, A; Suchy, FP; Wrobel, RL | 1 |
| Biener, G; Mavlyutov, T; Mishra, AK; Oliver, JA; Raicu, V; Ruoho, A; Singh, DR; Yang, J | 1 |
| Abramyan, AM; Bonifazi, A; Fant, AD; Guthrie, DA; Hong, WC; Newman, AH; Schneck, SN; Shi, L; Xu, M; Yano, H | 1 |
| Betz, RM; Dror, RO; Kruse, AC; Schmidt, HR | 1 |
2 review(s) available for haloperidol and pentazocine
| Article | Year |
|---|---|
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.
Topics: Allosteric Regulation; Clinical Trials as Topic; Humans; Ligands; Nervous System Diseases; Piperidines; Receptors, sigma; Sigma-1 Receptor; Small Molecule Libraries | 2020 |
[Possible role of sigma-receptors in the regulation of cough reflex, gastrointestinal and retinal function].
Topics: Animals; Anti-Ulcer Agents; Antitussive Agents; Carbazoles; Guanidines; Haloperidol; Humans; Ligands; Pentazocine; Phenazocine; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Retinal Diseases | 1999 |
1 trial(s) available for haloperidol and pentazocine
| Article | Year |
|---|---|
[General anasthesia for outpatient termination of pregnancy. A prospective analysis of 6 different types of anesthetics].
Topics: Abortion, Induced; Adult; Anesthesia, General; Anesthesia, Obstetrical; Curare; Enflurane; Ethers; Female; Haloperidol; Humans; Pentazocine; Pregnancy; Prospective Studies | 1977 |
89 other study(ies) available for haloperidol and pentazocine
| Article | Year |
|---|---|
New piperidine-based derivatives as sigma receptor ligands. Synthesis and pharmacological evaluation.
Topics: Cell Line, Tumor; Humans; Ligands; Piperidines; Receptors, sigma | 2018 |
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.
Topics: Animals; Antineoplastic Agents; Binding Sites; Encephalomyelitis, Autoimmune, Experimental; HEK293 Cells; Humans; Interferon-gamma; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Docking Simulation; Protein Structure, Tertiary; Quinoxalines; Receptors, Opioid, kappa; Signal Transduction; Structure-Activity Relationship; Th1 Cells | 2019 |
Novel σ
Topics: Amination; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Humans; Male; Mice; Prostatic Neoplasms; Receptors, sigma; Sigma-1 Receptor; Structure-Activity Relationship | 2021 |
Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
Topics: Animals; Binding Sites; Blood-Brain Barrier; Drug Design; Guinea Pigs; Half-Life; Humans; Microsomes, Liver; Molecular Dynamics Simulation; Neuralgia; Pain Management; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Rats; Receptors, sigma; Sigma-1 Receptor; Triazoles | 2021 |
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation.
Topics: Animals; Guinea Pigs; Hydrogen; Hydrogen Sulfide; Ligands; Male; Morpholines; Pain; Piperazines; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor | 2022 |
Synthesis of 8-aminomorphans with high KOR affinity.
Topics: Molecular Conformation; Pyrrolidines; Receptors, Opioid, kappa; Stereoisomerism; Structure-Activity Relationship | 2022 |
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.
Topics: Ligands; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tropanes | 2022 |
Design, synthesis and biological evaluation of novel aminopropylcarboxamide derivatives as sigma ligands.
Topics: Haloperidol; Ligands; Piperidines; Quinolines; Receptors, sigma; Structure-Activity Relationship | 2022 |
Effect of narcotic analgesics on the striatal homovanillic acid content in mice; relation to antinociceptive effect.
Topics: Analgesics, Opioid; Animals; Body Temperature; Corpus Striatum; Cyclazocine; Haloperidol; Homovanillic Acid; Male; Methadone; Mice; Morphine; Pain; Pentazocine; Phenylacetates; Piperidines; Thebaine; Time Factors | 1976 |
Effects of opiates on the discriminative stimulus properties of dopamine agonists.
Topics: Amphetamine; Animals; Apomorphine; Discrimination, Psychological; Dopamine; Haloperidol; Male; Morphine; Naltrexone; Narcotics; Pentazocine; Rats; Time Factors | 1978 |
Competitive interactions at [3H]1,3-di(2-tolyl)guanidine (DTG)-defined sigma recognition sites in guinea pig brain.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Carbazoles; Dopamine Agents; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Male; Pentazocine; Piperidines; Radioligand Assay; Receptors, Opioid; Receptors, sigma | 1992 |
Characterization of the binding of [3H](+)-pentazocine to sigma recognition sites in guinea pig brain.
Topics: Animals; Antipsychotic Agents; Binding Sites; Binding, Competitive; Brain; Carbazoles; Dopamine Agents; Guinea Pigs; Haloperidol; Kinetics; Male; Pentazocine; Piperidines; Receptors, sigma | 1992 |
Ionic zinc may function as an endogenous ligand for the haloperidol-sensitive sigma 2 receptor in rat brain.
Topics: Animals; Binding, Competitive; Brain; Cations, Divalent; Copper; Electric Stimulation; Guanidines; Haloperidol; Hippocampus; Hydrogen-Ion Concentration; Kinetics; Male; Membranes; Pentazocine; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sensitivity and Specificity; Tritium; Zinc | 1992 |
1,3-Di(2-[5-3H]tolyl)guanidine labels more than one site in rat forebrain.
Topics: Animals; Binding Sites; Binding, Competitive; Carbamazepine; Guanidines; Haloperidol; Male; Pentazocine; Phenytoin; Piperidines; Prosencephalon; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism | 1992 |
Binding affinity and antimuscarinic activity of sigma and phencyclidine receptor ligands.
Topics: Animals; Binding, Competitive; Carbachol; Cerebral Cortex; Dioxolanes; Guinea Pigs; Haloperidol; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; N-Methylscopolamine; Parasympatholytics; Pentazocine; Phosphatidylinositols; Piperidines; Receptors, Muscarinic; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine; Scopolamine Derivatives | 1991 |
[Characteristics and regulation of 3H-haloperidol binding to rat brain sigma receptors].
Topics: Animals; Binding Sites; Brain; Haloperidol; In Vitro Techniques; Male; Pentazocine; Rats; Rats, Inbred Strains; Receptors, Opioid | 1991 |
Similar behavioural effects of sigma agonists and PCP-like non-competitive NMDA antagonists in guinea-pigs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzamides; Dizocilpine Maleate; Dopamine Agents; Dopamine Antagonists; Ergolines; Female; Guanidines; Guinea Pigs; Haloperidol; Ketamine; Male; Motor Activity; N-Methylaspartate; Pentazocine; Phenazocine; Phencyclidine; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride | 1991 |
Rat cortical sigma receptors differentially regulated by pentazocine and haloperidol.
Topics: Animals; Down-Regulation; Frontal Lobe; Haloperidol; Kinetics; Male; Narcotic Antagonists; Pentazocine; Protein Binding; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1991 |
The lack of utility of the rat vas deferens as a functional bioassay for sigma ligands.
Topics: Animals; Binding Sites; Biological Assay; Electric Stimulation; Guanidines; Guinea Pigs; Haloperidol; Male; Muscle Contraction; Pentazocine; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Vas Deferens | 1991 |
Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors.
Topics: Animals; Brain; Haloperidol; In Vitro Techniques; Male; Motor Activity; Parasympathetic Nervous System; Pentazocine; Phosphatidylinositols; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, sigma | 1990 |
A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain.
Topics: Adrenal Gland Neoplasms; Affinity Labels; Animals; Benzomorphans; Binding, Competitive; Brain; Cell Differentiation; Cell Line; Cell Membrane; Guanidines; Guinea Pigs; Haloperidol; Kinetics; Nerve Growth Factors; Pentazocine; Pheochromocytoma; Rats; Receptors, Opioid; Receptors, sigma | 1990 |
The effect of prototypic sigma ligands on the binding of [3H]dextromethorphan to guinea pig brain.
Topics: Animals; Antitussive Agents; Binding, Competitive; Brain; Dextromethorphan; Guinea Pigs; Haloperidol; Levorphanol; Pentazocine; Receptors, Opioid; Receptors, Opioid, delta | 1989 |
Neuropeptide Y and peptide YY interact with rat brain sigma and PCP binding sites.
Topics: Animals; Brain Chemistry; Haloperidol; In Vitro Techniques; Male; Neuropeptide Y; Pentazocine; Peptide YY; Peptides; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1989 |
Guinea-pig vas deferens preparation may contain both receptors and phencyclidine receptors.
Topics: Animals; Antipsychotic Agents; Carbazoles; Electric Stimulation; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pentazocine; Receptors, Neurotransmitter; Receptors, Phencyclidine; Vas Deferens | 1987 |
[Intense pentazocine abstinence syndrome. Treatment of a clinical case].
Topics: Administration, Oral; Adult; Butyrophenones; Diazepam; Drug Evaluation; Female; Haloperidol; Humans; Injections, Intravenous; Pentazocine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1974 |
[Anesthesia for thoracic surgeons. 2. Modern anesthesia and anesthetics].
Topics: Allyl Compounds; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Benperidol; Diazepam; Fentanyl; Haloperidol; Humans; Isonipecotic Acids; Neuroleptanalgesia; Pancuronium; Pentazocine; Propanidid; Thoracic Surgery; Thorax; Toxiferine | 1972 |
[Clinical study on modified neuroleptanalgesia].
Topics: Benperidol; Chlorpromazine; Diazepam; Haloperidol; Humans; Hydroxybutyrates; Middle Aged; Neuroleptanalgesia; Pentazocine; Tranquilizing Agents | 1971 |
Neuroleptanalgesia.
Topics: Alcoholism; Analgesics; Bronchography; Burns; Dextromoramide; Fentanyl; Haloperidol; Hearing Disorders; Humans; Neuroleptanalgesia; Parkinson Disease; Pentazocine; Phenoperidine; Respiration, Artificial | 1969 |
[2 methods of labor analgesia].
Topics: Anesthesia, Conduction; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics, Local; Drug Synergism; Female; Haloperidol; Humans; Methoxyflurane; Pentazocine; Pregnancy | 1969 |
Pentazocine, a potent analgesic: evaluation for anaesthetic use.
Topics: Anesthesia, General; Blood Pressure; Carbon Dioxide; Haloperidol; Humans; Methylphenidate; Neuroleptanalgesia; Pentazocine; Pulse; Respiration; Spirometry | 1969 |
Neurotransmitter-blocking agents influence antinociceptive effects of carbamazepine, baclofen, pentazocine and morphine on bradykinin-induced trigeminal pain.
Topics: Analgesics; Animals; Atropine; Baclofen; Bicuculline; Bradykinin; Carbamazepine; Haloperidol; Male; Methysergide; Morphine; Naloxone; Neurotransmitter Agents; Pentazocine; Rats; Rats, Inbred Strains; Sympatholytics; Trigeminal Neuralgia; Trigeminal Nucleus, Spinal | 1984 |
[Pharmacological action of eptazocine (l-1,4-dimethyl-10-hydroxy-2,3,4,5,6,7-hexahydro-1,6-methano-1H-4-benzazonine). Effects of eptazocine on spontaneous movements].
Topics: Analgesics; Animals; Apomorphine; Cyclazocine; Disulfiram; Haloperidol; Male; Morphine; Movement; Naloxone; Pentazocine; Rats; Rats, Inbred Strains | 1983 |
Stability of five liquid drug products after unit dose repackaging.
Topics: Drug Packaging; Drug Stability; Haloperidol; Isoetharine; Kinetics; Medication Systems, Hospital; Pentazocine; Phenytoin; Promethazine; Temperature | 1980 |
Functional and binding properties of sigma receptors in rat cerebellum.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclohexylamines; Female; Glycine; Haloperidol; Male; N-Methylaspartate; Norepinephrine; Pentazocine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism | 1995 |
Ibogaine possesses a selective affinity for sigma 2 receptors.
Topics: Animals; Guinea Pigs; Haloperidol; Ibogaine; In Vitro Techniques; Pentazocine; Receptors, sigma; Structure-Activity Relationship | 1995 |
Phosphorylation of synapsin I and dynamin in rat forebrain synaptosomes: modulation by sigma (sigma) ligands.
Topics: Animals; Anticonvulsants; Dynamins; GTP Phosphohydrolases; Guanidines; Haloperidol; In Vitro Techniques; Microtubules; Pentazocine; Phenazocine; Phosphorylation; Prosencephalon; Rats; Receptors, sigma; Synapsins; Synaptosomes | 1995 |
Oocytes from Xenopus laevis contain an intrinsic sigma 2-like binding site.
Topics: Animals; Binding Sites; Binding, Competitive; Carbazoles; Dextromethorphan; Female; Guanidines; Haloperidol; Liver; Mazindol; Oocytes; Pentazocine; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Rats; Receptors, sigma; Xenopus laevis; Zinc | 1994 |
Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures.
Topics: Animals; Calcium; Cells, Cultured; Cyclazocine; Cyclopentanes; Dextromethorphan; Glutamic Acid; Guanidines; Haloperidol; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Pentazocine; Phenazocine; Piperidines; Rats; Receptors, sigma | 1995 |
Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.
Topics: Adenocarcinoma; Animals; Binding, Competitive; Breast Neoplasms; Carcinoma, Ductal, Breast; Glioblastoma; Guanidines; Haloperidol; Humans; Leukemia; Lung Neoplasms; Male; Melanoma; Mice; Neuroblastoma; Pentazocine; Prostatic Neoplasms; Receptors, sigma; Tumor Cells, Cultured | 1995 |
Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling.
Topics: Affinity Labels; Animals; Binding, Competitive; Cell Membrane; Haloperidol; In Vitro Techniques; Kidney; Levallorphan; Liver; Male; Molecular Biology; Pentazocine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism | 1994 |
Sigma-receptor regulation of [3H]arachidonic acid release from rat neonatal cerebellar granule cells in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Arachidonic Acid; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Haloperidol; Kinetics; Melitten; N-Methylaspartate; Neurons; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Tritium | 1994 |
Selective antagonism of opioid analgesia by a sigma system.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Haloperidol; Male; Mice; Morphine; Narcotic Antagonists; Pentazocine; Pyrrolidines; Receptors, sigma; Species Specificity | 1994 |
Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes.
Topics: Animals; Calcium; Cells, Cultured; GTP-Binding Proteins; Guanidines; Haloperidol; Heart Rate; Myocardial Contraction; Pentazocine; Piperidines; Rats; Receptors, sigma; Sarcoplasmic Reticulum | 1994 |
Differential effects of repeated dl-pentazocine treatment on sigma binding sites in discrete brain areas of the rat.
Topics: Animals; Anticonvulsants; Brain Chemistry; Dextroamphetamine; Guanidines; Haloperidol; Kinetics; Male; Methamphetamine; Pentazocine; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism | 1994 |
(+)-[C-11]-cis-N-benzyl-normetazocine: a selective ligand for sigma receptors in vivo.
Topics: Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Cyclazocine; Haloperidol; Kinetics; Ligands; Male; Mice; Organ Specificity; Pentazocine; Phencyclidine; Piperidines; Receptors, sigma; Spiperone; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed | 1994 |
The effects of sigma ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin.
Topics: Animals; Anticonvulsants; Cinnamates; Cyclopropanes; Drug Synergism; GTP-Binding Proteins; Guanidines; Haloperidol; Hippocampus; Ligands; Male; N-Methylaspartate; Neurons; Neuropeptide Y; Pentazocine; Pertussis Toxin; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, sigma; Virulence Factors, Bordetella | 1994 |
Functional antagonism of morphine analgesia by (+)-pentazocine: evidence for an anti-opioid sigma 1 system.
Topics: Analgesia; Animals; Dopamine D2 Receptor Antagonists; Drug Interactions; Haloperidol; Male; Mice; Morphine; Pentazocine; Receptors, sigma; Stereoisomerism; Sulpiride | 1993 |
Signalling via rat dopamine D2-receptors expressed in mouse fibroblasts is not influenced by compounds binding to the sigma sites of these cells.
Topics: Animals; Binding, Competitive; Cell Communication; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Fibroblasts; Haloperidol; Mice; Pentazocine; Rats; Receptors, Dopamine D2; Receptors, sigma; Signal Transduction | 1993 |
Multiple [3H]DTG binding sites in guinea pig cerebellum: evidence for the presence of non-specific binding.
Topics: Animals; Anticonvulsants; Binding, Competitive; Cerebellum; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Levallorphan; Liver; Male; Membranes; Models, Biological; Pentazocine; Receptors, sigma | 1994 |
In vivo modulation of sigma receptor sites by calcitonin gene-related peptide in the mouse and rat hippocampal formation: radioligand binding and electrophysiological studies.
Topics: Animals; Antipsychotic Agents; Calcitonin Gene-Related Peptide; Dopamine Antagonists; Electrophysiology; Haloperidol; Hippocampus; In Vitro Techniques; Iontophoresis; Male; Membranes; Mice; Narcotics; Neuropeptide Y; Pentazocine; Phenazocine; Pyramidal Cells; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1995 |
Sigma receptor activation does not mediate fentanyl-induced attenuation of muscarinic coronary contraction.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Coronary Vessels; Cyclazocine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fentanyl; Guanidines; Haloperidol; Muscarine; Muscarinic Agonists; Narcotic Antagonists; Narcotics; Pentazocine; Phencyclidine; Piperidines; Potassium Channel Blockers; Receptors, Dopamine; Receptors, sigma; Signal Transduction; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
The effects of sigma ligands on protein release from lacrimal acinar cells: a potential agonist/antagonist assay.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Eye Proteins; Guanidines; Haloperidol; In Vitro Techniques; Lacrimal Apparatus; Pentazocine; Phenethylamines; Pyrimidines; Rabbits; Receptors, sigma | 1995 |
Apparent desensitization of a sigma receptor sub-population in neonatal rat cardiac myocytes by pre-treatment with sigma receptor ligands.
Topics: Animals; Animals, Newborn; Down-Regulation; Haloperidol; Heart; Muscle Contraction; Myocardium; Pentazocine; Rats; Receptors, Opioid, delta; Time Factors | 1996 |
Involvement of sigma-receptors in the increase in contraction of mouse vas deferens induced by exogenous ATP.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Carbazoles; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Haloperidol; Ligands; Male; Mice; Muscle Contraction; Muscle, Smooth; Pentazocine; Phenazocine; Piperidines; Receptors, sigma; Regression Analysis; Structure-Activity Relationship; Vas Deferens | 1996 |
Dissociation of the motor effects of (+)-pentazocine from binding to sigma 1 sites.
Topics: Aging; Animals; Central Nervous System Depressants; Dystonia; Haloperidol; Head Movements; In Vitro Techniques; Male; Membranes; Movement; Narcotic Antagonists; Narcotics; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Red Nucleus; Substantia Nigra | 1996 |
(-)-Pentazocine analgesia in mice: interactions with a sigma receptor system.
Topics: Analgesics, Opioid; Animals; Base Sequence; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Oligonucleotides, Antisense; Pentazocine; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, mu; Receptors, sigma | 1995 |
Differential solubilization of rat liver sigma 1 and sigma 2 receptors: retention of sigma 2 sites in particulate fractions.
Topics: Animals; Binding, Competitive; Cell Fractionation; Cell Membrane; Cholic Acids; Detergents; Guanidines; Haloperidol; In Vitro Techniques; Liver; Male; Pentazocine; Phenazocine; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Solubility; Subcellular Fractions | 1996 |
Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices.
Topics: Animals; Anisoles; Anticonvulsants; Antipsychotic Agents; Cyclohexylamines; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Ligands; Male; N-Methylaspartate; Narcotics; Norepinephrine; Pentazocine; Propylamines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Tritium | 1996 |
[3H]1,3-di(2-tolyl) guanidine binds to a sigma 2 receptor on Jurkat cell membranes, but sigma compounds fail to influence immunomodulatory events in human peripheral blood lymphocytes.
Topics: Binding, Competitive; Cell Membrane; Guanidines; Haloperidol; Humans; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Narcotics; Pentazocine; Protein Binding; Receptors, sigma; T-Lymphocytes | 1996 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Haloperidol; Humans; Kinetics; Morphine; Naloxone; Neuroblastoma; Pentazocine; Phosphatidylinositols; Receptors, Opioid; Receptors, sigma; Trypsin; Tumor Cells, Cultured | 1996 |
Regulation of [3H] dopamine release from mesolimbic and mesocortical areas of guinea pig brain by sigma receptors.
Topics: Analgesics; Analysis of Variance; Animals; Cyclohexylamines; Dopamine; Dopamine Antagonists; Guinea Pigs; Haloperidol; N-Methylaspartate; Nucleus Accumbens; Pentazocine; Prefrontal Cortex; Pyrrolidines; Receptors, sigma; Schizophrenia | 1996 |
Differential localization of three distinct binding sites for sigma receptor ligands in rat spleen.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Autoradiography; Binding Sites; Dopamine Agonists; Dopamine Antagonists; Female; Guanidines; Haloperidol; Image Processing, Computer-Assisted; Ligands; Male; Naltrexone; Narcotic Antagonists; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Spleen; Tritium | 1997 |
Effect of short-term and long-term treatments with sigma ligands on the N-methyl-D-aspartate response in the CA3 region of the rat dorsal hippocampus.
Topics: Animals; Cinnamates; Cyclopropanes; Guanidines; Haloperidol; Hippocampus; Male; N-Methylaspartate; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1997 |
Multiple [3H]-nemonapride binding sites in calf brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Benzamides; Binding, Competitive; Brain; Cattle; Cerebellum; Cerebral Cortex; Corpus Striatum; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Guanidines; Haloperidol; In Vitro Techniques; Isotope Labeling; Narcotic Antagonists; Pentazocine; Piperidines; Propylamines; Pyrrolidines; Receptors, Dopamine D2; Receptors, sigma; Sulpiride; Tritium | 1997 |
Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism.
Topics: Amnesia; Amyloid beta-Peptides; Analgesics, Opioid; Animals; Antipsychotic Agents; Avoidance Learning; Dehydroepiandrosterone; Haloperidol; Injections, Intraventricular; Male; Mice; Morpholines; Pentazocine; Peptide Fragments; Piperazines; Pregnenolone; Progesterone; Receptors, sigma | 1998 |
Cloning and functional characterization of a sigma receptor from rat brain.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Antidepressive Agents; Base Sequence; Binding, Competitive; Brain Chemistry; Choriocarcinoma; Cloning, Molecular; Clorgyline; DNA, Complementary; Dopamine Antagonists; Gene Expression; Gene Library; Guanidines; Haloperidol; HeLa Cells; Humans; Kinetics; Liver; Molecular Sequence Data; Narcotics; Pentazocine; Phenytoin; Placenta; Rats; Receptors, sigma; RNA, Messenger; Steroids | 1998 |
Sigma-binding site ligands inhibit K+ currents in rat locus coeruleus neurons in vitro.
Topics: Action Potentials; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Cell Membrane; Dextromethorphan; Dopamine Antagonists; Enkephalin, Methionine; Excitatory Amino Acid Antagonists; Guanidines; Haloperidol; In Vitro Techniques; Ligands; Locus Coeruleus; Male; Narcotics; Neurons; Pentazocine; Potassium Channels; Rats; Rats, Sprague-Dawley | 1998 |
Molecular and ligand-binding characterization of the sigma-receptor in the Jurkat human T lymphocyte cell line.
Topics: Alternative Splicing; Amino Acid Sequence; Blotting, Northern; Cell Membrane; Cloning, Molecular; DNA; Dopamine Antagonists; Haloperidol; HeLa Cells; Humans; Jurkat Cells; Ligands; Molecular Sequence Data; Narcotic Antagonists; Pentazocine; Progesterone; Receptors, sigma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vaccinia virus | 1999 |
Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.
Topics: Action Potentials; Animals; Antipsychotic Agents; Brain Stem; Cell Membrane; Cytoplasm; GTP-Binding Proteins; Guinea Pigs; Haloperidol; In Vitro Techniques; Isoenzymes; Ligands; Male; Pentazocine; Pertussis Toxin; Phenazocine; Protein Kinase C; Protein Kinase C beta; Receptors, sigma; Respiratory Mechanics; Reverse Transcriptase Polymerase Chain Reaction; Type C Phospholipases; Virulence Factors, Bordetella | 1999 |
Effects of streptozotocin-induced diabetes on neuronal sigma receptors in the rat brain.
Topics: Analgesics, Opioid; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Glycosuria; Guanidines; Haloperidol; Kinetics; Male; Pentazocine; Rats; Rats, Wistar; Receptors, sigma | 1999 |
Repeated haloperidol treatment decreases sigma(1) receptor binding but does not affect its mRNA levels in the guinea pig or rat brain.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Haloperidol; Male; Pentazocine; Radioligand Assay; Rats; Rats, Wistar; Receptors, sigma; RNA, Messenger; Tritium | 2000 |
Evidence that the sigma(1) receptor is not directly coupled to G proteins.
Topics: Animals; Cerebellum; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Haloperidol; Liver; Male; Pentazocine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor | 2000 |
Multiple pathways of sigma(1) receptor ligand uptakes into primary cultured neuronal cells.
Topics: Animals; Anisoles; Arsenicals; Biological Transport; Calcium; Calcium-Transporting ATPases; Calmodulin; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Haloperidol; Hydroquinones; Kinetics; Ligands; Neurons; Ouabain; Pentazocine; Piperazines; Propylamines; Pyrrolidines; Rats; Receptors, sigma; Sigma-1 Receptor; Sodium; Sulfonamides; Tartrates; Thapsigargin; Time Factors; Tritium | 2001 |
Binding of sigma receptor ligands and their effects on muscarine-induced Ca(2+) changes in SH-SY5Y cells.
Topics: Binding, Competitive; Calcium; Cyclohexylamines; Dose-Response Relationship, Drug; Haloperidol; Humans; Muscarine; Pentazocine; Pyrrolidines; Radioligand Assay; Receptors, sigma; Sigma-1 Receptor; Tritium; Tumor Cells, Cultured | 2002 |
Sigma1 receptor modulation of opioid analgesia in the mouse.
Topics: Analgesics, Opioid; Animals; Central Nervous System; Down-Regulation; Drug Synergism; Haloperidol; Injections, Spinal; Male; Mice; Mice, Inbred BALB C; Narcotic Antagonists; Oligodeoxyribonucleotides, Antisense; Pain Measurement; Pentazocine; Receptors, sigma; Sigma-1 Receptor | 2002 |
Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Calcium; Calcium Channels; Cells, Cultured; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Ganglia, Parasympathetic; Gene Expression; Guanidines; Guanosine Diphosphate; Guanosine Triphosphate; Haloperidol; Ibogaine; Ion Channel Gating; Membrane Potentials; Microdialysis; Neurons; Pentazocine; Rats; Receptors, sigma; RNA, Messenger; Signal Transduction; Superior Cervical Ganglion; Thionucleotides | 2002 |
Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines.
Topics: Animals; Anisoles; Antineoplastic Agents; Binding, Competitive; Brain; Cell Line, Tumor; Guanidines; Guinea Pigs; Haloperidol; Humans; In Vitro Techniques; Ligands; Liver; Membranes; Pentazocine; Piperazines; Propylamines; Pyridines; Radioligand Assay; Rats; Receptors, sigma; Sigma-1 Receptor | 2004 |
Modulation of bradykinin-induced calcium changes in SH-SY5Y cells by neurosteroids and sigma receptor ligands via a shared mechanism.
Topics: Binding Sites; Bradykinin; Calcium; Calcium Signaling; Cell Line, Tumor; Dehydroepiandrosterone; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Fura-2; Haloperidol; Humans; Narcotics; Neuroblastoma; Pentazocine; Pregnenolone; Time Factors | 2004 |
Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503.
Topics: Animals; Autoradiography; Binding, Competitive; Brain; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluorine Radioisotopes; Guanidines; Guinea Pigs; Haloperidol; Inhibitory Concentration 50; Ligands; Male; Narcotic Antagonists; Pentazocine; Piperazines; Protein Binding; Radioligand Assay; Radiopharmaceuticals; Receptors, sigma; Structure-Activity Relationship | 2006 |
Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells.
Topics: Animals; Binding, Competitive; Brain; Cell Line, Tumor; Dopamine Antagonists; Guinea Pigs; Haloperidol; Humans; Male; Molecular Structure; Narcotic Antagonists; Neurons; Pentazocine; Radioligand Assay; Receptor Aggregation; Receptors, sigma; Sigma-1 Receptor; Subcellular Fractions | 2007 |
In vivo characterization of radioiodinated (+)-2-[4-(4-iodophenyl) piperidino] cyclohexanol as a potential sigma-1 receptor imaging agent.
Topics: Animals; Autoradiography; Biotransformation; Brain; Central Nervous System; Chemical Phenomena; Chemistry, Physical; Cyclohexanols; Haloperidol; Iodine Radioisotopes; Isotope Labeling; Male; Narcotic Antagonists; Nootropic Agents; Pentazocine; Piperazines; Piperidines; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Tissue Distribution | 2007 |
An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones.
Topics: Binding, Competitive; Butyrophenones; Cell Line, Tumor; Central Nervous System Agents; Cloning, Molecular; Dopamine Agents; Dose-Response Relationship, Drug; Fluvoxamine; Haloperidol; Humans; Ligands; Methamphetamine; Molecular Structure; Pentazocine; Progesterone; Protein Binding; Radioligand Assay; Receptors, Dopamine D4; Receptors, sigma; Reproducibility of Results; Sigma-1 Receptor; Structure-Activity Relationship; Transfection; Tritium | 2008 |
Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems.
Topics: Adenosine Triphosphate; Animals; Antipsychotic Agents; Cell Line; Chlorocebus aethiops; COS Cells; Guanosine Triphosphate; Haloperidol; Humans; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Proteins; Myocytes, Cardiac; Narcotics; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Pentazocine; Phenazocine; Receptors, sigma; RNA, Small Interfering; Sodium; Sodium Channels | 2009 |
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
Topics: Analysis of Variance; Animals; Brain; Capsaicin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Hyperalgesia; Mice; Morpholines; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pentazocine; Physical Stimulation; Protein Binding; Radioligand Assay; Reaction Time; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Tritium | 2009 |
The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry.
Topics: Cell Line; Chromatography, Affinity; Gene Knockdown Techniques; Haloperidol; Humans; Ligands; Membrane Potentials; Microscopy, Atomic Force; NAV1.5 Voltage-Gated Sodium Channel; Pentazocine; Protein Binding; Protein Multimerization; Protein Structure, Quaternary; Receptors, sigma; RNA Interference; Sigma-1 Receptor; Single-Cell Analysis | 2012 |
The oligomeric states of the purified sigma-1 receptor are stabilized by ligands.
Topics: Amino Acid Motifs; Amino Acid Substitution; Animals; Cross-Linking Reagents; Guinea Pigs; Haloperidol; Humans; Ligands; Maltose-Binding Proteins; Models, Molecular; Mutagenesis, Site-Directed; Pentazocine; Protein Multimerization; Protein Stability; Receptors, sigma; Recombinant Fusion Proteins; Sigma-1 Receptor | 2014 |
The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands.
Topics: Amino Acid Substitution; Analgesics, Opioid; Animals; Cell Membrane; Chlorocebus aethiops; COS Cells; Dimerization; Endoplasmic Reticulum; Haloperidol; Humans; Ligands; Luminescent Proteins; Models, Molecular; Narcotic Antagonists; Pentazocine; Point Mutation; Protein Aggregates; Protein Stability; Receptors, sigma; Recombinant Fusion Proteins; Sigma-1 Receptor | 2015 |
Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.
Topics: Animals; Bioluminescence Resonance Energy Transfer Techniques; Cerebral Cortex; Dopamine Antagonists; Guinea Pigs; Haloperidol; HEK293 Cells; Humans; Isoxazoles; Ligands; Male; Molecular Docking Simulation; Pentazocine; Protein Binding; Protein Conformation; Pyridines; Receptors, sigma; Sigma-1 Receptor; Transfection; Tritium | 2018 |
Structural basis for σ
Topics: Anisoles; Crystallography, X-Ray; Haloperidol; Humans; Ligands; Models, Molecular; Molecular Docking Simulation; Pentazocine; Propylamines; Protein Domains; Receptors, sigma | 2018 |