haloperidol has been researched along with n-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eyles, DW; Jones, A; McGrath, JJ; McLennan, HR; Pond, SM; Stedman, TJ | 1 |
| Ablordeppey, SY; Borne, RF | 1 |
| Castagnoli, N; D'Engelbronner, J; Igarashi, K; Rollema, H; Skolnik, M; Usuki, E | 1 |
| Eyles, DW; McGrath, JJ; Pond, SM | 1 |
| Castagnoli, N; Fukui, M; Igarashi, K; Kasuya, F; Usuki, E | 1 |
| Avent, KM; Eyles, DW; Pond, SM; Stedman, TJ | 1 |
| Anemo, K; Igarashi, K; Iwahashi, K; Nakamura, K; Yoshihara, E | 1 |
| Iida, Y; Kawashima, H; Kitamura, Y; Kiyono, Y; Magata, Y; Saji, H | 1 |
| Kalgutkar, AS; Nguyen, HT | 1 |
| Iida, Y; Kawashima, H; Kitamura, Y; Saji, H | 1 |
10 other study(ies) available for haloperidol and n-(4'-fluorobutyrophenone)-4-(4-chlorophenyl)pyridinium
| Article | Year |
|---|---|
Quantitative analysis of two pyridinium metabolites of haloperidol in patients with schizophrenia.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Haloperidol; Humans; Male; Middle Aged; Pyridinium Compounds; Schizophrenia | 1994 |
Detection of a neurotoxic quaternary pyridinium metabolite in the liver of haloperidol-treated rats.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Haloperidol; Indicators and Reagents; Liver; Male; Oxalates; Pyridinium Compounds; Rana pipiens; Rats; Rats, Wistar | 1993 |
MPP(+)-like neurotoxicity of a pyridinium metabolite derived from haloperidol: in vivo microdialysis and in vitro mitochondrial studies.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Haloperidol; Lactates; Lactic Acid; Male; Mice; Microdialysis; Mitochondria, Liver; Nervous System; Pyridinium Compounds; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Serotonin | 1994 |
Formation of pyridinium species of haloperidol in human liver and brain.
Topics: Adolescent; Brain; Dopamine Antagonists; Haloperidol; Humans; Liver; Male; Middle Aged; Pyridinium Compounds; Subcellular Fractions | 1996 |
Studies on the metabolism of haloperidol (HP): the role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HP.
Topics: Animals; Antibodies; Antipsychotic Agents; Biotransformation; Brain; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Haloperidol; Injections, Intraperitoneal; Ketoconazole; Male; Microsomes, Liver; Mitochondria; Mixed Function Oxygenases; Nifedipine; Pyridinium Compounds; Rats; Rats, Sprague-Dawley | 1995 |
Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem.
Topics: Antipsychotic Agents; Autopsy; Bile; Brain; Chromatography, High Pressure Liquid; Haloperidol; Humans; Pyridinium Compounds; Reference Standards; Tissue Distribution | 1997 |
Analysis of the metabolism of haloperidol (HP) and its neurotoxic pyridinium metabolite (HPP+) in patients with drug-induced parkinsonism.
Topics: Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Haloperidol; Humans; Middle Aged; Mixed Function Oxygenases; Parkinson Disease, Secondary; Pyridinium Compounds | 2000 |
Brain extraction of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP+), a neurotoxic metabolite of haloperidol: studies using [3H]HPP+.
Topics: Animals; Blood-Brain Barrier; Brain; Haloperidol; Male; Mice; Pyridinium Compounds; Rats; Rats, Wistar | 2002 |
Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Antidiarrheals; Bupropion; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dealkylation; Haloperidol; Humans; Hydroxylation; Ketoconazole; Loperamide; Male; Microsomes, Liver; NADP; Neurons; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Binding of 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]pyridinium ion (HPP+), a metabolite of haloperidol, to synthetic melanin: implications for the dopaminergic neurotoxicity of HPP+.
Topics: Animals; Cells, Cultured; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Female; Haloperidol; Melanins; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Neurons; Pregnancy; Protein Binding; Pyridinium Compounds; Rats; Rats, Sprague-Dawley | 2004 |