haloperidol and fluvoxamine

haloperidol has been researched along with fluvoxamine in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (13.16)	18.2507
2000's	18 (47.37)	29.6817
2010's	13 (34.21)	24.3611
2020's	2 (5.26)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Adkison, KK; Humphreys, JE; Mahar Doan, KM; Polli, JW; Serabjit-Singh, CJ; Shampine, LJ; Webster, LO; Wring, SA	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Glen, RC; Lowe, R; Mitchell, JB	1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Buschmann, H; Holenz, J; Oberdorf, C; Schepmann, D; Vela, JM; Wünsch, B	1
Gunosewoyo, H; Kozikowski, AP; Yu, LF; Zhang, HK	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Qin, W; Tian, S; Wold, EA; Xu, Q; Ye, N; Zhen, XC; Zhou, J	1
Barrelet, L; Baumann, P; Touabi, M; Uehlinger, C	1
Goodman, WK; McDougle, CJ; Price, LH	1
Abi-Dargham, A; Daniel, DG; Egan, M; Elkashef, A; Handel, S; Jaskiw, G; Liboff, S; Randolph, C; Shoaf, S; Williams, T	1
Goodman, WK; Heninger, GR; Leckman, JF; Lee, NC; McDougle, CJ; Price, LH	1
Earley, B; Faherty, CJ; Leonard, BE	1
Reznik, I; Sirota, P	1
Esumi, E; Kojima, S; Maruka, Y	1
Kurasawa, M; Nakamura, K	1
Kanba, S; Miyaoka, H; Nakaki, T; Shintani, F; Suzuki, E	1
Nakamura, J; Ohmori, O; Terao, T; Ueda, N	1
Inoue, Y; Kaneko, S; Kondo, T; Mihara, K; Yasui-Furukori, N	1
Ago, Y; Baba, A; Matsuda, T; Nakamura, S	1
Chertkow, Y; Silver, H; Weinreb, O; Youdim, MB	2
Machida, N; Semba, J; Shiotsuka, S	1
Chen, S; Lee, IT; Schetz, JA	1
Faaij, RA; Van der Cammen, TJ; Ziere, G; Zietse, R	1
Hasegawa, R; Ikeda, K; Karasawa, J; Tamura, K; Yamamoto, H; Yamamoto, T; Yasumoto, S	1
Danovich, L; Silver, H; Weinreb, O; Youdim, MB	1
Balci, F; Campbell, U; Hanania, T; Olivier, BE; Paterson, NE	1
Coffman, CF; Fiacco, NR; Granger, JC; Helton, BM; Jackson, JC; Kim, LV; Kreiss, DS; Mistry, RS; Mizer, TM; Palmer, LV; Vacca, JA; Winkler, SS; Zimmer, BA	1
Arikawa, A; Hayashida, K; Maebayashi, K; Matsunaga, H; Mito, H; Motoyama, M; Yamanishi, K	1
Bilker, W; Einoch, R; Mandiuk, N; Silver, H; Weinreb, O; Youdim, MBH	1
Albayrak, Y; Beyazyüz, E; Çelikkol, A; Mengi, M; Uslu, ET	1

Reviews

3 review(s) available for haloperidol and fluvoxamine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases. Journal of medicinal chemistry, 2020, 12-24, Volume: 63, Issue:24 Topics: Allosteric Regulation; Clinical Trials as Topic; Humans; Ligands; Nervous System Diseases; Piperidines; Receptors, sigma; Sigma-1 Receptor; Small Molecule Libraries	2020
Dopamine antagonists in tic-related and psychotic spectrum obsessive compulsive disorder. The Journal of clinical psychiatry, 1994, Volume: 55 Suppl Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Clomipramine; Clozapine; Dopamine Antagonists; Drug Therapy, Combination; Female; Fluvoxamine; Haloperidol; Humans; Isoxazoles; Male; Obsessive-Compulsive Disorder; Piperidines; Risperidone; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Tic Disorders; Tourette Syndrome	1994

Trials

4 trial(s) available for haloperidol and fluvoxamine

Article	Year
Coadministration of fluvoxamine increases serum concentrations of haloperidol. Journal of clinical psychopharmacology, 1994, Volume: 14, Issue:5 Topics: Adult; Benztropine; Chronic Disease; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Fluvoxamine; Haloperidol; Humans; Male; Middle Aged; Neurologic Examination; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1994
Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. Archives of general psychiatry, 1994, Volume: 51, Issue:4 Topics: Adolescent; Adult; Age of Onset; Behavior Therapy; Comorbidity; Double-Blind Method; Drug Therapy, Combination; Female; Fluvoxamine; Haloperidol; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Placebos; Psychiatric Status Rating Scales; Tic Disorders; Treatment Outcome	1994
Obsessive and compulsive symptoms in schizophrenia: a randomized controlled trial with fluvoxamine and neuroleptics. Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:4 Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Compulsive Behavior; Female; Fluvoxamine; Haloperidol; Humans; Male; Middle Aged; Obsessive Behavior; Perphenazine; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	2000
Fluvoxamine dose-dependent interaction with haloperidol and the effects on negative symptoms in schizophrenia. Psychopharmacology, 2004, Volume: 171, Issue:2 Topics: Adult; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Synergism; Female; Fluvoxamine; Haloperidol; Humans; Inpatients; Male; Middle Aged; Schizophrenia; Selective Serotonin Reuptake Inhibitors	2004

Other Studies

31 other study(ies) available for haloperidol and fluvoxamine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cell Line; Cell Membrane Permeability; Central Nervous System Agents; Dogs; Drug Delivery Systems; Permeability; Pharmaceutical Preparations	2002
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery. Journal of medicinal chemistry, 2007, Sep-20, Volume: 50, Issue:19 Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats	2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution	2011
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Thiophene bioisosteres of spirocyclic σ receptor ligands: relationships between substitution pattern and σ receptor affinity. Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11 Topics: Animals; Brain; Guinea Pigs; Ligands; Liver; Models, Molecular; Piperidines; Pyrans; Radioligand Assay; Rats; Receptors, sigma; Spiro Compounds; Structure-Activity Relationship; Thiophenes	2012
From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design. ACS medicinal chemistry letters, 2012, Dec-13, Volume: 3, Issue:12 Topics:	2012
Alopecia and mood stabilizers: two case reports. European archives of psychiatry and clinical neuroscience, 1992, Volume: 242, Issue:2-3 Topics: Adult; Alopecia; Carbamazepine; Clorazepate Dipotassium; Depressive Disorder; Female; Fluvoxamine; Haloperidol; Hospitalization; Humans; Lithium Carbonate; Methotrimeprazine; Middle Aged; Schizophrenia; Valproic Acid	1992
Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat. Journal of psychopharmacology (Oxford, England), 1997, Volume: 11, Issue:1 Topics: 1-Naphthylamine; Animals; Behavior, Animal; Chlorpromazine; Citalopram; Fluoxetine; Fluvoxamine; Guanidines; Haloperidol; Male; Microinjections; Motor Activity; Paroxetine; Piperidines; Posture; Rats; Rats, Sprague-Dawley; Receptors, sigma; Red Nucleus; Selective Serotonin Reuptake Inhibitors; Sertraline	1997
Tandospirone, a promising alternative drug in the treatment of chorea. Internal medicine (Tokyo, Japan), 2000, Volume: 39, Issue:12 Topics: Animals; Atrophy; Cerebral Cortex; Chorea; Dementia; Dopamine Antagonists; Female; Fluvoxamine; Haloperidol; Humans; Isoindoles; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Middle Aged; Piperazines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Trinucleotide Repeat Expansion	2000
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. European journal of pharmacology, 2001, May-18, Volume: 420, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological	2001
Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain. Neuroscience letters, 2002, Nov-29, Volume: 333, Issue:3 Topics: Animals; Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Brain; Carbamazepine; Chlorpromazine; Diazepam; Fluvoxamine; Gene Expression; Haloperidol; Isoxazoles; Lithium; Male; Maprotiline; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Zonisamide	2002
Schneiderian first-rank symptoms associated with fluvoxamine treatment: a case report. Human psychopharmacology, 2003, Volume: 18, Issue:6 Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Delusions; Diagnosis, Differential; Fluvoxamine; Hallucinations; Haloperidol; Humans; Male; Panic Disorder; Treatment Outcome	2003
Sulpiride in combination with fluvoxamine increases in vivo dopamine release selectively in rat prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:1 Topics: Animals; Antidepressive Agents, Second-Generation; Dopamine; Dopamine Agonists; Dopamine Antagonists; Fluvoxamine; Haloperidol; Male; Microdialysis; Neostriatum; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Sulpiride	2005
The effect of chronic co-administration of fluvoxamine and haloperidol compared to clozapine on the GABA system in the rat frontal cortex. The international journal of neuropsychopharmacology, 2006, Volume: 9, Issue:3 Topics: Animals; Clozapine; Drug Therapy, Combination; Fluvoxamine; Frontal Lobe; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Haloperidol; Isoenzymes; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A	2006
[Case of obsessive-compulsive disorder associated with neuroleptics-induced deficit syndrome (NIDS): successfully treated by discontinuation of neuroleptics followed by SSRI]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2005, Volume: 107, Issue:7 Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Fluvoxamine; Haloperidol; Humans; Male; Middle Aged; Obsessive-Compulsive Disorder; Personality Disorders; Risperidone; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Treatment Outcome	2005
Dopamine and serotonin metabolism in response to chronic administration of fluvoxamine and haloperidol combined treatment. Journal of neural transmission (Vienna, Austria : 1996), 2007, Volume: 114, Issue:11 Topics: Animals; Antipsychotic Agents; Behavior, Animal; Body Weight; Brain; Clozapine; Dopamine; Dopamine Antagonists; Drug Interactions; Fluvoxamine; Haloperidol; Immunohistochemistry; Male; Motor Activity; Neostriatum; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Tyrosine 3-Monooxygenase	2007
An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones. European journal of pharmacology, 2008, Jan-14, Volume: 578, Issue:2-3 Topics: Binding, Competitive; Butyrophenones; Cell Line, Tumor; Central Nervous System Agents; Cloning, Molecular; Dopamine Agents; Dose-Response Relationship, Drug; Fluvoxamine; Haloperidol; Humans; Ligands; Methamphetamine; Molecular Structure; Pentazocine; Progesterone; Protein Binding; Radioligand Assay; Receptors, Dopamine D4; Receptors, sigma; Reproducibility of Results; Sigma-1 Receptor; Structure-Activity Relationship; Transfection; Tritium	2008
Delirium due to a drug-drug interaction of lithium and an NSAID. The journal of nutrition, health & aging, 2009, Volume: 13, Issue:3 Topics: Accidental Falls; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Delirium; Depressive Disorder, Major; Diclofenac; Drug Interactions; Female; Fluid Therapy; Fluvoxamine; Follow-Up Studies; Haloperidol; Humans; Lithium Carbonate; Pain	2009
Inhibitory effect of selective serotonin reuptake inhibitors on the vesicular monoamine transporter 2. Neuroscience letters, 2009, May-01, Volume: 454, Issue:3 Topics: Animals; Dopamine; Fluoxetine; Fluvoxamine; Haloperidol; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Paroxetine; Rats; Rats, Wistar; Reserpine; Selective Serotonin Reuptake Inhibitors; Synaptic Vesicles; Vesicular Monoamine Transport Proteins	2009
The involvement of GABA(A) receptor in the molecular mechanisms of combined selective serotonin reuptake inhibitor-antipsychotic treatment. The international journal of neuropsychopharmacology, 2011, Volume: 14, Issue:2 Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cells, Cultured; Clozapine; Dopamine; Drug Therapy, Combination; Fluvoxamine; Haloperidol; Male; Mitogen-Activated Protein Kinase 1; Mood Disorders; Obsessive-Compulsive Disorder; Phosphorylation; Prefrontal Cortex; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia; Selective Serotonin Reuptake Inhibitors	2011
The triple reuptake inhibitor DOV216,303 exhibits limited antidepressant-like properties in the differential reinforcement of low-rate 72-second responding assay, likely due to dopamine reuptake inhibition. Journal of psychopharmacology (Oxford, England), 2011, Volume: 25, Issue:10 Topics: Animals; Antidepressive Agents; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Desipramine; Diazepam; Dopamine Uptake Inhibitors; Fluvoxamine; Haloperidol; Imipramine; Male; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology	2011
Ritualistic chewing behavior induced by mCPP in the rat is an animal model of obsessive compulsive disorder. Pharmacology, biochemistry, and behavior, 2013, Volume: 104 Topics: Animals; Behavior, Animal; Clomipramine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Fluvoxamine; GABA Modulators; Haloperidol; Male; Mastication; Mianserin; Obsessive-Compulsive Disorder; Piperazines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists	2013
[A Case with Multiple Comorbidities of Obsessive-Compulsive and Related Disorders]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2015, Volume: 117, Issue:11 Topics: Adult; Antipsychotic Agents; Aripiprazole; Body Dysmorphic Disorders; Clonazepam; Combined Modality Therapy; Comorbidity; Diagnostic and Statistical Manual of Mental Disorders; Drug Therapy, Combination; Female; Fluvoxamine; Haloperidol; Hoarding Disorder; Humans; Obsessive-Compulsive Disorder; Psychotherapy; Self-Injurious Behavior; Skin; Trichotillomania; Young Adult	2015
The involvement of BDNF-CREB signaling pathways in the pharmacological mechanism of combined SSRI- antipsychotic treatment in schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2017, Volume: 27, Issue:5 Topics: Adult; Animals; Antipsychotic Agents; Brain-Derived Neurotrophic Factor; CREB-Binding Protein; Drug Combinations; Embryo, Mammalian; Female; Fluvoxamine; Haloperidol; Hippocampus; Humans; In Vitro Techniques; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Signal Transduction	2017
The effects of sigma-1 agonist fluvoxamine on experimental induced tardive dyskinesia model in rats. Progress in neuro-psychopharmacology & biological psychiatry, 2023, Aug-30, Volume: 126 Topics: Animals; Antipsychotic Agents; Brain-Derived Neurotrophic Factor; Dyskinesias; Fluvoxamine; Haloperidol; Male; Nerve Growth Factor; Rats; Rats, Wistar; Superoxide Dismutase; Tardive Dyskinesia; Tetrabenazine	2023