Compounds > haloperidol

haloperidol and debrisoquin

haloperidol has been researched along with debrisoquin in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (30.77)	18.7374
1990's	5 (38.46)	18.2507
2000's	3 (23.08)	29.6817
2010's	1 (7.69)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bertilsson, L; Dahl, ML; Ekqvist, B; Llerena, A	3
Alm, C; Bertilsson, L; Dahl, ML; Ekqvist, B; Llerena, A	1
Davidson, M; Davis, BM; Davis, KL; Freed, LB; Lesser, JC; Losonczy, MF; Mohs, RC; Mykytyn, VV; Powchik, P	1
Bowden, CL; Contreras, SA; Maas, JW; Seleshi, E	1
Heninger, GR; Roth, RH; Sternberg, DE	1
Heninger, GR; Kendler, KS; Roth, RH	1
Bowden, C; Castiglioni, J; Contreras, S; Maas, JW; Miller, AL; Seleshi, E; True, JE	1
Berecz, R; de la Rubia, A; Dorado, P; LLerena, A	2

Reviews

1 review(s) available for haloperidol and debrisoquin

Article	Year
Disposition of the neuroleptics perphenazine, zuclopenthixol, and haloperidol cosegregates with polymorphic debrisoquine hydroxylation. Psychopharmacology series, 1993, Volume: 10 Topics: Antipsychotic Agents; Clopenthixol; Debrisoquin; Haloperidol; Humans; Hydroxylation; Perphenazine; Polymorphism, Genetic	1993

Trials

2 trial(s) available for haloperidol and debrisoquin

Article	Year
Acute effects of neuroleptics on unmedicated schizophrenic patients and controls. Biological psychiatry, 1993, Aug-01, Volume: 34, Issue:3 Topics: Adult; Antipsychotic Agents; Brain; Debrisoquin; Dopamine; Haloperidol; Homovanillic Acid; Humans; Male; Methoxyhydroxyphenylglycol; Placebos; Plasma; Schizophrenia	1993
QTc interval lengthening and debrisoquine metabolic ratio in psychiatric patients treated with oral haloperidol monotherapy. European journal of clinical pharmacology, 2002, Volume: 58, Issue:3 Topics: Administration, Oral; Adult; Aged; Antipsychotic Agents; Debrisoquin; Female; Gas Chromatography-Mass Spectrometry; Haloperidol; Humans; Long QT Syndrome; Male; Middle Aged; Psychotic Disorders	2002

Other Studies

10 other study(ies) available for haloperidol and debrisoquin

Article	Year
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers. Therapeutic drug monitoring, 1992, Volume: 14, Issue:3 Topics: Chromatography, High Pressure Liquid; Debrisoquin; Haloperidol; Humans; Hydroxylation; Oxidation-Reduction; Phenotype	1992
Genetic factors in the metabolism of haloperidol. Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A Topics: Debrisoquin; Half-Life; Haloperidol; Humans; Hydroxylation; Phenotype	1992
Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype. Therapeutic drug monitoring, 1992, Volume: 14, Issue:2 Topics: Adult; Chromatography, High Pressure Liquid; Debrisoquin; Female; Half-Life; Haloperidol; Humans; Hydroxylation; Male; Middle Aged; Phenotype	1992
Effects of debrisoquin and haloperidol on plasma homovanillic acid concentration in schizophrenic patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1987, Volume: 1, Issue:1 Topics: Adult; Debrisoquin; Drug Therapy, Combination; Haloperidol; Homovanillic Acid; Humans; Isoquinolines; Male; Schizophrenia; Time Factors	1987
Increase in human urine homovanillic acid concentration after neuroleptic treatment is the same with or without debrisoquin administration. Archives of general psychiatry, 1987, Volume: 44, Issue:12 Topics: Brain; Debrisoquin; Dopamine; Haloperidol; Homovanillic Acid; Humans; Isoquinolines; Male; Schizophrenia	1987
Plasma homovanillic acid as an index of brain dopamine metabolism: enhancement with debrisoquin. Life sciences, 1983, May-23, Volume: 32, Issue:21 Topics: Animals; Brain; Debrisoquin; Dopamine; Haloperidol; Homovanillic Acid; Isoquinolines; Male; Phenylacetates; Rats; Rats, Inbred Strains	1983
Brain contribution to the haloperidol-induced increase in plasma homovanillic acid. European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3 Topics: Animals; Benzimidazoles; Brain; Corpus Striatum; Debrisoquin; Domperidone; Haloperidol; Homovanillic Acid; Male; Phenylacetates; Piperidines; Rats; Receptors, Dopamine	1981
Relationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients. Pharmacopsychiatry, 2004, Volume: 37, Issue:2 Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Debrisoquin; Female; Genotype; Haloperidol; Humans; Male; Mental Disorders; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrophotometry, Ultraviolet; Statistics, Nonparametric	2004