haloperidol has been researched along with clozapine in 1530 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 240 (15.69) | 18.7374 |
| 1990's | 458 (29.93) | 18.2507 |
| 2000's | 548 (35.82) | 29.6817 |
| 2010's | 251 (16.41) | 24.3611 |
| 2020's | 33 (2.16) | 2.80 |
| Authors | Studies |
|---|---|
| Kehr, JR; Kukla, MJ; Miller, A; Woo, CM | 1 |
| Ellefson, CR; Kehr, JR; Miller, A; Woo, CM | 1 |
| Baldy, WJ; Barrett, DL; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Kukla, MJ; Martin, GE; Mathiasen, JR; Scott, MK | 1 |
| Arnt, J; Bøgesø, KP; Hyttel, J; Perregaard, J; Sánchez, C | 1 |
| Bregna, DE; Dunn, RW; Geyer, HM; Hartman, HB; Hrib, NJ; Jurcak, JG; Roehr, JE; Rogers, KL; Rush, DK; Szczepanik, AM | 1 |
| Andrieux, M; Besançon, R; Giros, B; Martres, MP; Pilon, C; Schwartz, JC; Sokoloff, P | 1 |
| Bernstein, E; Dextraze, P; Eison, MS; Lobeck, WG; New, JS; Taylor, DP; Temple, DL; Yevich, JP; Yocca, FD | 1 |
| Dunn, RW; Errico, CL; Hrib, NJ; Huger, FP; Jurcak, JG | 1 |
| Ewing, FE; Furman, JS; Heym, JH; Howard, HR; Lowe, JA; Nagel, AA; Newman, ME; Schmidt, AW; Seeger, TF; Seymour, PA | 1 |
| George, SR; Guan, HC; Laurier, LG; Ng, G; Niznik, HB; O'Dowd, BF; Seeman, P; Sunahara, RK; Torchia, J; Van Tol, HH | 1 |
| Bouthenet, ML; Giros, B; Martres, MP; Schwartz, JC; Sokoloff, P | 1 |
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Cascio, G; Fregnan, G; Manghisi, E | 1 |
| Butler, DE; Coughenour, LL; DeWald, HA; Downs, DA; Lewis, EP; Lobbestael, SJ; Pattison, IC; Poschel, BP; Tecle, H; Wise, LD | 1 |
| Catt, JD; Eison, MS; Lobeck, WG; Minielli, JL; New, JS; Riblet, LA; Smith, DW; Taylor, DP; Temple, DL; Yevich, JP | 1 |
| Butler, DE; Coughenour, LL; DeWald, HA; Downs, DA; Heffner, TG; Lustgarten, D; Pugsley, TA; Wise, LD | 1 |
| Abou-Gharbia, M; Moyer, JA; Muth, EA; Patel, UR | 1 |
| Abou-Gharbia, M; Andree, TH; Moyer, JA; Muth, EA; Patel, UR; Webb, MB | 1 |
| Beeson, NW; Coughenour, LL; DeWald, HA; Downs, DA; Heffner, TG; Hershenson, FM; Pugsley, TA; Wise, LD | 1 |
| Bordner, J; Dominy, BW; Donahue, KM; Howard, HR; Koe, BK; Sarges, R; Weissman, A; Welch, WM | 1 |
| Andrews, PR; Craik, DJ; Martin, JL | 1 |
| Chakrabarti, JK; Horsman, L; Hotten, TM; Pullar, IA; Tupper, DE; Wright, FC | 1 |
| Chakrabarti, JK; Fairhurst, J; Gutteridge, NJ; Horsman, L; Pullar, IA; Smith, CW; Steggles, DJ; Tupper, DE; Wright, FC | 1 |
| Brougham, LR; Ellefson, CR; Miller, A; Prodan, KA | 1 |
| Chakrabarti, JK; Chaney, MO; Hotten, TM; Jones, ND; Morgan, SE; Pullar, IA; Rackham, DM; Risius, FC; Wedley, S | 1 |
| New, JS; Riblet, LA; Taylor, DP; Temple, DL; Yevich, JP | 1 |
| Audiau, F; Carpy, A; Guérémy, C; Le Fur, G; Léger, JM; Uzan, A | 1 |
| Glennon, RA; Nelson, S; Salley, JJ; Steinsland, OS | 1 |
| Ellefson, CR; Prodan, KA | 1 |
| Baxter, EW; Bennett, DJ; Blum, PS; Boyd, RE; Codd, EE; Kukla, MJ; Malloy, E; Maryanoff, BE; Maryanoff, CA; Scott, MK | 1 |
| Baxter, EW; Bennett, DJ; Codd, EE; Jordan, AD; Malloy, EA; Maryanoff, BE; McDonnell, ME; Ortegon, ME; Reitz, AB; Renzi, MJ | 1 |
| Bordeau, KJ; Chiang, Y; Conway, PG; Corbett, R; Glamkowski, EJ; Hartman, HB; Helsley, GC; Strupczewski, JT; Szewczak, MR; Wilmot, CA | 1 |
| Cornfield, L; Gerber, K; Harris, K; Huston, K; Hutchison, A; Meade, R; Peterson, J; Ramabhadran, TV; Ross, PC; Thurkauf, A | 1 |
| Abreu, ME; Bailey, MA; Ferkany, JW; Kaiser, C; Karbon, EW; Mathew, RM; Mewshaw, RE; Silverman, LS; Tiffany, CW | 1 |
| Bruhwyler, J; Chleide, EM; Damas, J; Delarge, JE; Inarejos, MO; Liégeois, JF; Mercier, MG; Nguyen, TP; Rogister, FA | 1 |
| Demattos, S; MacKenzie, RG; O'Malley, KL; Pugsley, TA; Shih, YH; Tang, L; Todd, RD; VanLeeuwen, D | 1 |
| Choudhary, MS; Craigo, SC; Meltzer, HY; Monsma, FJ; Roth, BL; Shen, Y; Sibley, DR; Uluer, A | 1 |
| Bennett, DJ; Blum, PS; Codd, EE; Maryanoff, CA; Ortegon, ME; Reitz, AB; Renzi, MJ; Scott, MK; Shank, RP; Vaught, JL | 1 |
| Burgher, KL; Conway, PG; Hartman, HB; Hrib, NJ; Jurcak, JG; Kerman, LL; Roehr, JE; Woods, AT | 1 |
| Cooper, BR; Navas, F; Norman, MH; Rigdon, GC | 1 |
| Clemens, JA; Fairhurst, J; Pullar, IA; Risius, FC; Timms, GH; Tupper, DE; Wedley, S | 1 |
| Bruhwyler, J; Chleide, EM; Damas, J; Delarge, JE; Liégeois, JF; Mercier, MG; Nguyen, TP; Rogister, FA | 1 |
| Evans, DL; Figur, LM; Lahti, RA; Stratman, NC | 1 |
| Emms, F; Freedman, SB; Knowles, MR; Marwood, R; McAllister, G; Patel, S; Seabrook, GR | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E | 1 |
| Chen, X; Huston, K; Meade, R; Ross, PC; Thurkauf, A; Wasley, JW; Woodruff, KH; Yuan, J | 1 |
| Ewing, FE; Furman, JS; Howard, HR; Jackson, E; Johnson, C; Lowe, JA; Maloney, PR; Morrone, J; Newman, ME; Robinson, GL; Schmidt, AW; Seeger, TF; Seymour, PA; Zorn, SH | 1 |
| Minick, DJ; Norman, MH; Rigdon, GC | 1 |
| Baker, R; Broughton, HB; Curtis, NR; Emms, F; Freedman, SB; Kulagowski, JJ; Leeson, PD; Marwood, R; Mawer, IM; Patel, S; Ragan, CI; Ridgill, MP | 1 |
| Baker, R; Broughton, HB; Collins, I; Emms, F; Freedman, SB; Leeson, PD; Marwood, R; Patel, S; Ragan, CI; Rowley, M | 1 |
| Hattori, H; Hidaka, K; Maeno, K; Mase, T; Matsumoto, M; Nakato, K; Ohmori, J; Sakamoto, S; Tada, S; Tsukamoto, S; Usuda, S | 1 |
| Anglada, L; Bolós, J; Burgarolas, C; Castelló, JM; Gubert, S; Ortiz, JA; Planas, JM; Sacristán, A | 1 |
| Bregna, DE; Burgher, KL; Corbett, R; Hartman, HB; Hrib, NJ; Jurcak, JG; Kafka, S; Kerman, LL; Kongsamut, S; Roehr, JE; Szewczak, MR; Woods-Kettelberger, AT | 1 |
| De Loore, K; Gommeren, W; Janssen, PF; Lesage, AS; Leysen, JE; Luyten, WH; Schotte, A; Van Gompel, P | 1 |
| Cai, J; Hartman, HB; Kerman, LL; Kongsamut, S; Roehr, JE; Sandrasagra, A; Tang, L; Weissensee, P | 1 |
| Chen, X; Donovan, H; He, XS; Hoffman, DC; Hutchison, A; Jones-Hertzog, DK; Meade, R; Thurkauf, A; Wasley, JW; Woodruff, KH; Yuan, J | 1 |
| Baker, R; Ball, R; Broughton, HB; Collins, I; Davey, WB; Emms, F; Freedman, SB; Leeson, PD; Marwood, R; Patel, S; Ragan, CI; Rowley, M | 1 |
| Capiris, T; Connor, DT; Heffner, TG; MacKenzie, RG; Miller, SR; Pugsley, TA; Unangst, PC; Wise, LD | 1 |
| Capiris, T; Connor, DT; Doubleday, R; Heffner, TG; MacKenzie, RG; Miller, SR; Pugsley, TA; Unangst, PC; Wise, LD | 1 |
| DeBoer, P; Liao, Y; Meier, E; Wikström, H | 1 |
| Baez, M; Kursar, JD; Lucaites, VL; Nelson, DL; Sasso, DA; Wainscott, DB | 1 |
| Asmakova, LS; Bondarenko, NA; Briling, VK; Gudasheva, TA; Ostrovskaya, RU; Rozantsev, GG; Seredenin, SB; Voronina, TA; Zaitseva, NI | 1 |
| Brasili, L; Di Toro, R; Giannella, M; Melchiorre, C; Piergentili, A; Pigini, M; Quaglia, W; Rossetti, L; Spampinato, S | 1 |
| Baxter, EW; Codd, EE; Davis, CB; Jordan, AD; Maryanoff, BE; Maryanoff, CA; McDonnell, ME; Powell, ET; Reitz, AB; Renzi, MJ; Schott, MR; Scott, MK; Shank, RP; Vaught, JL | 1 |
| Caignard, DH; Depreux, P; Diouf, O; Guardiola-Lemaître, B; Lesieur, D; Pfeiffer, B; Poupaert, JH; Renard, P; Rettori, MC; Taverne, T | 1 |
| Egan, CT; Herrick-Davis, K; Teitler, M | 1 |
| Audinot, V; Cussac, D; Gobert, A; Lavielle, G; Lejeune, F; Millan, MJ; Muller, O; Newman-Tancredi, A; Nicolas, JP; Rivet, JM | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Berardi, F; Colabufo, NA; Leopoldo, M; Perrone, R; Tortorella, V | 2 |
| Chappie, TA; Collins, JL; Desai, KA; Duignan, DB; Dunaiskis, AR; Faraci, WS; Fliri, AF; Jackson, ER; Johnson, CG; Lee, JS; Majchrzak, MJ; Morrone, JM; Prete Di, CC; Sanner, MA; Seymour, PA; Trozzi, A; Zorn, SH | 1 |
| Agut, J; Anglada, L; Bolós, J; De la Fuente, N; Gubert, S; Ortiz, JA; Planas, JM; Príncep, M; Sacristán, A | 1 |
| Fontenla, JA; Formoso, E; Loza, MI; Masaguer, CF; Raviña, E; Rivas, E; Tristán, H | 1 |
| Bartoszyk, GD; Böttcher, H; Liao, Y; Meier, E; Rodenhuis, N; Seyfried, CA; Sundell, S; Timmerman, W; Venhuis, BJ; Wikström, H | 1 |
| Cadavid, MI; Carotti, A; Carrieri, A; Cid, J; Fontenla, JA; Loza, MI; Lozoya, E; Masaguer, CF; Negreira, J; Raviña, E; Rivas, ME; Rosa, E; Sanz, F; Tristán, H | 1 |
| Birch, AM; Bradley, PA; Gill, JC; Kerrigan, F; Needham, PL | 1 |
| Ikeda, K; Kobayashi, T; Kumanishi, T | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Beroza, P; Bradley, EK; Grootenhuis, PD; Miller, JL; Penzotti, JE; Spellmeyer, DC | 1 |
| Bacolod, MD; Brodbeck, R; Craven, K; Girard, B; Hodgetts, K; Hoffman, D; Kieltyka, A; Rachwal, S; Thurkauf, A; Tran, J; Wasley, JW; Zhang, X; Zhao, H | 1 |
| Cadavid, MI; Casariego, I; Demontis, GC; Enguix, MJ; Fontenla, JA; Loza, MI; Masaguer, CF; Montenegro, GY; Raviña, E; Rivas, ME; Villazon, M | 1 |
| Klitgaard, H; Matagne, A; Talaga, P | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| de Moes, J; Feenstra, RW; Hofma, JJ; Kling, H; Kruse, CG; Kuipers, W; Long, SK; Tulp, MT; van der Heyden, JA | 1 |
| Brea, J; Cadavid, MI; Caro, Y; Carotti, A; Carrieri, A; Centeno, NB; Enguix, MJ; Loza, MI; Masaguer, CF; Mengod, G; Raviña, E; Rodrigo, J; Sanz, F; Villazón, M | 1 |
| Butini, S; Cagnotto, A; Campiani, G; Carminati, P; Castorina, M; Catalanotti, B; Di Cesare, MA; Fattorusso, C; Galletti, B; Gemma, S; Ghirardi, O; Giorgi, G; Goegan, M; Mastroianni, D; Mennini, T; Minetti, P; Nacci, V; Pacifici, L; Scafetta, N; Stasi, MA; Tinti, O | 1 |
| Boulton, DW; DeVane, CL; Liston, HL; Markowitz, JS | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Altomare, C; Asproni, B; Biggio, G; Bitti, M; Busonero, F; Cerri, R; Dazzi, L; Maciocco, E; Melosu, M; Pau, A; Pusceddu, L; Sanna, E; Seu, E; Talani, G; Trapani, G | 1 |
| Brodbeck, R; He, X; Hoffman, D; Kieltyka, A; Primus, R; Thurkauf, A; Wasley, JW; Zhao, H | 1 |
| Bruhwyler, J; Carato, P; Damas, J; Delarge, J; Ellenbroek, BA; Eyrolles, L; Géczy, J; Lejeune, C; Liégeois, JF | 1 |
| Berardi, F; Colabufo, NA; De Giorgio, P; Lacivita, E; Leopoldo, M; Perrone, R; Tortorella, V | 1 |
| Andersen, K; Balle, T; Larsen, AK; Liljefors, T; Perregaard, J; Ramirez, MT; Søby, KK | 1 |
| Ernsberger, P; Hufeisen, SJ; Jayathilake, K; Kroeze, WK; Meltzer, HY; Popadak, BA; Renock, SM; Roth, BL; Steinberg, S | 1 |
| Glennon, RA | 1 |
| Keserü, GM | 1 |
| Fang, X; Hu, Z; Levant, B; Min, J; Varady, J; Wang, S; Wu, X | 1 |
| Ablordeppey, SY; Li, S; Lyles-Eggleston, M; Sikazwe, DM | 1 |
| Butini, S; Cagnotto, A; Campiani, G; Carli, M; Carminati, P; Castorina, M; Catalanotti, B; Di Cesare, MA; Di Serio, S; Fattorusso, C; Galletti, B; Gemma, S; Ghirardi, O; Mastroianni, D; Mennini, T; Mereghetti, I; Minetti, P; Morelli, E; Nacci, V; Pacifici, L; Scafetta, N; Stasi, MA; Tinti, O; Vertechy, M | 1 |
| Ablordeppey, SY; Altundas, R; Borne, RF; Fan, P; Li, S; Lyles-Eggleston, M; Schmidt, AW; Shrihkande, A; Sikazwe, DM; Vanase-Frawley, M; Villalobos, A; Xia, J; Yang, Q; Zhang, W; Zhu, X | 1 |
| Brea, J; Caro, Y; Loza, MI; Masaguer, CF; Padín, F; Raviña, E; Torrado, M | 1 |
| Wermuth, CG | 1 |
| Andersson, CM; Bradley, SR; Brann, MR; Davis, RE; Hacksell, U; Harvey, SC; Kold, H; Makhay, M; Son, T; Spalding, TA; Tolf, BR; Vanover, KE; Veinbergs, I; Weiner, DM | 1 |
| Brioni, JD; Chang, R; Donnelly-Roberts, DL; Fan, L; Kolasa, T; Matulenko, MA; Miller, LN; Moreland, RB; Nakane, M; Namovic, MT; Stewart, AO; Surber, B; Terranova, MA; Uchic, ME | 1 |
| Li, J; Rajamani, R; Reynolds, CH; Tounge, BA | 1 |
| Butini, S; Cagnotto, A; Campiani, G; Carminati, P; Catalanotti, B; Di Cesare, MA; Di Serio, S; Fattorusso, C; Fiorini, I; Gemma, S; Ghirardi, O; Mennini, T; Mereghetti, I; Minetti, P; Nacci, V; Stasi, MA; Tinti, O; Trotta, F | 1 |
| Alonso, JM; Andrés, JI; Cid, JM; Díaz, A; Fernández, J; Gil, P; Iturrino, L; Megens, A; Sipido, VK; Trabanco, AA | 1 |
| Alvarado, M; Brea, J; Coelho, A; Loza, MI; Masaguer, CF; Padín, JF; Raviña, E | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Ablordeppey, SY; Bricker, B; Goodman, C; Lyles-Eggleston, M; Roth, BL; Zhang, W; Zhu, X | 1 |
| Allouchi, H; Argiolas, A; El Hakmaoui, A; Enguehard-Gueiffier, C; Gmeiner, P; Gueiffier, A; Hübner, H; Melis, MR | 1 |
| Bhatia, P; Brioni, JD; Chang, R; Donnelly-Roberts, DL; El Kouhen, O; Hakeem, AA; Henry, R; Hollingsworth, PR; Hsieh, GC; Kolasa, T; Marsh, KC; Martino, B; Matulenko, MA; Miller, LN; Moreland, RB; Mortell, K; Nakane, M; Namovic, MT; Patel, MV; Stewart, AO; Terranova, MA; Uchic, ME; Wetter, JM | 1 |
| Brioni, JD; Chang, R; Cowart, MD; Darbyshire, JF; Donnelly-Roberts, DL; El-Kouhen, OF; Gintant, G; Hakeem, AA; Hollingsworth, PR; Hsieh, GC; Kolasa, T; Marsh, KC; Martin, R; Martino, BR; Matulenko, MA; Miller, LN; Moreland, RB; Mortell, K; Nakane, M; Namovic, MT; Nelson, SL; Patel, MV; Rohde, JJ; Stewart, AO; Sullivan, JP; Terranova, MA; Uchic, ME; Wetter, JM | 1 |
| Dorsey, J; Katz, T; Lawlor, E; Messer, WS; Nagy, PI; Rieman, M; Tejada, FR; Warrier, M; Wu, C; Xu, M | 1 |
| Huang, AS; Kim, SF; Snowman, AM; Snyder, SH; Teuscher, C | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Areias, FM; Barceló, M; Brea, J; Domínguez, E; Loza, MI; Masaguer, CF; Raviña, E | 1 |
| Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H | 1 |
| Andrić, D; Ignjatović, D; Kostić-Rajacić, S; Roglić, G; Tomić, M; Tovilović, G | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Coolen, HK; Glennon, JC; Kruse, CG; Lange, JH; Reinders, JH; Tolboom, JT | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Shahid, M; Walker, GB; Wong, EH; Zorn, SH | 1 |
| Bariwal, JB; Chauhan, BS; Jain, KS; Kathiravan, MK; Phoujdar, MS; Sahne, RS; Shah, AK; Yadav, MR | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Ablordeppey, SY; Altundas, R; Bricker, B; Jackson, T; Khan, A; Kumar, EV; Roth, BL; Zhu, XY | 1 |
| Aranda, R; Areias, F; Brea, J; Domínguez, E; López, L; Loza, MI; Masaguer, CF; Pastor, M; Raviña, E; Sanz, F; Selent, J; Villalba, K | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Andreasen, JT; Bernetti, M; Borriello, M; Brindisi, M; Butini, S; Cagnotto, A; Campiani, G; Ceres, N; Coccone, SS; De Angelis, M; Fattorusso, C; Fiorini, I; Franceschini, S; Gemma, S; Mennini, T; Mikkelsen, JD; Nacci, V; Novellino, E; Ros, S; Sandager-Nielsen, K; Scheel-Kruger, J; Trotta, F | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Giordanetto, F; Leach, AG; Zachariae, U | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Brea, J; Carro, L; Domínguez, E; Loza, MI; Masaguer, CF; Raviña, E | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Antonio, CB; Barreiro, EJ; Fraga, CA; Grazziottin, LR; Menegatti, R; Neves, G; Noël, F; Rates, SM; Vieira, RO | 1 |
| Borrelli, G; Butini, S; Campiani, G; Fattorusso, C; Fiorini, I; Franceschini, S; Gemma, S; Guarino, E; Jacobsen, TA; Kumar, V; Madsen, K; Novellino, E; Orteca, N; Persico, M; Sandager-Nielsen, K; Scheel-Kruger, J; Trotta, F | 1 |
| Glen, RC; Lowe, R; Mitchell, JB | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
| Sen, S; Sinha, N | 1 |
| Bartolome, JM; Langlois, X; Macdonald, GJ; Tresadern, G | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Kumar, S; Singh, R; Wahi, AK | 1 |
| Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T | 1 |
| Ablordeppey, SY; Eyunni, SV; Peprah, K; Roth, BL; Setola, V; Zhu, XY | 1 |
| Bojarski, AJ; Duszyńska, B; Jastrzębska-Więsek, M; Marciniec, K; Maślankiewicz, A; Partyka, A; Pawłowski, M; Satała, G; Wesołowska, A; Wróbel, D; Zajdel, P | 1 |
| Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS | 1 |
| Chappie, TA; Helal, CJ; Hou, X | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Dalvie, D; Loi, CM; Smith, DA | 1 |
| Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
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| Bernstein, HG; Bogerts, B; Gos, T; Keilhoff, G; Sarnyai, Z; Steiner, J; Westphal, S | 1 |
| Goodwin, DG; Lindsay, DS; Strobl, JS | 1 |
| D'Aquila, PS; Franconi, F; Galistu, A; Modde, C; Pireddu, MC; Serra, G | 1 |
| MacGillivray, L; Mazurek, MF; Reynolds, KB; Rosebush, PI; Zettler, M | 1 |
| He, E; Li, M; Volf, N | 1 |
| Akhondzadeh, S; Boroumand, MA; Ghaleiha, A; Honarbakhsh, N; Jafarinia, M; Raznahan, M; Rezaei, F; Tabrizi, M | 1 |
| Cecil, KM; Dunn, RS; Lindquist, DM | 1 |
| Di Cosimo, D; Girardi, N; Kotzalidis, GD; Lazanio, S; Manfredi, G; Savoja, V; Talamo, A; Tatarelli, R; Vento, A | 1 |
| He, W; Heupel, K; Li, M | 1 |
| Accordini, S; Barbui, C; Cipriani, A; Esposito, E; Girlanda, F; Nosè, M; Purgato, M; Stroup, S; Tansella, M; Veronese, A | 1 |
| Barkhatova, NA; Bogdanova, ED; Brusov, OS; Faktor, MI; Kaleda, VG; Koliaskina, GI; Vasil'eva, EF | 1 |
| Czobor, P; Krakowski, M | 1 |
| Alhussainy, T; Attallah, LJ; Matalka, KZ; Qinna, NA | 1 |
| De Silva, PN | 1 |
| Bertani, S; Carboni, L; Cavanni, P; Fratte, SD; Michielin, F; Negri, M; Oliosi, B | 1 |
| Anderson, P; Jones, NC; O'Brien, TJ; Pinault, D; Reddy, M; Salzberg, MR | 1 |
| Farrell, MS; Kroeze, WK; Roth, BL; Yadav, PN | 1 |
| Chen, ML; Lee, MC; Lin, YY; Tsai, FM; Tsai, TC; Tsai, YM; Wang, LK | 2 |
| Chen, CH; Chen, PY; Chiu, CC; Huang, MC; Liu, HC; Lu, ML | 1 |
| Andreotti, S; Gattaz, WF; Lima, FB; Passos-Bueno, MR; Sertié, AL; Sertié, RA; Suzuki, AM | 1 |
| Faludi, G; Fejes, L; Inczédy-Farkas, G; Kassai-Farkas, A; Lazáry, J; Makkos, Z | 1 |
| Motomura, E; Nakagawa, M; Okada, M; Tanahashi, S; Yamamura, S | 1 |
| Body, S; Bradshaw, CM; Cassaday, HJ; Goudie, AJ; Olarte-Sánchez, CM; Szabadi, E; Valencia Torres, L | 1 |
| Constant, E; Jacques, D; Manceaux, P; Reynaert, C; Zdanowicz, N | 1 |
| Body, S; Bradshaw, CM; de Bruin, N; den Boon, FS; Hampson, CL; Szabadi, E | 1 |
| Rushlow, WJ; Sutton, LP | 1 |
| Allenet, B; Bosson, JL; Genty, C; Schmidlin, S | 1 |
| Campos-Rodriguez, UE; Cano-Cruz, MA; Saldívar-González, JA | 1 |
| Engel, RH; Fatemi, SH; Folsom, TD; Novak, J; Reutiman, TJ | 1 |
| Dudova, I; Hrdlicka, M; Urbanek, T; Zedkova, I | 1 |
| Bishnoi, M; Boparai, RK | 1 |
| Zhu, MZ | 1 |
| Umeda, K | 1 |
| An, H; Chung, S; Kim, DH; Kim, J; Park, J; Seo, J; Yoon, SY | 1 |
| Johnsen, E; Kroken, RA | 1 |
| Bauer, M; Blaich, C; Falkai, P; Gruber, O; Rietschel, M; Schmitt, A; Schneider-Axmann, T; Schulze, T; Treutlein, J; Wilmsdorff, MV; Zink, M | 1 |
| Czernikiewicz, A; Kucharska-Pietura, K; Mortimer, A; Tylec, A | 1 |
| Li, M; Sun, T; Zhao, C | 1 |
| Meltzer, HY; Porter, JH; Vunck, SA; Wiebelhaus, JM | 1 |
| Adzu, B; Chindo, BA; Gamaniel, KS; Yahaya, TA | 1 |
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| Wysokiński, A | 1 |
| Gurling, HM; Harrison, A; Hunt, SP; McQuillin, A; Ng, A; Rizig, MA; Robinson, M; Zvelebil, M | 1 |
| González-Maeso, J; Holloway, T; Moreno, JL; Rayannavar, V; Sealfon, SC; Umali, A | 1 |
| Kirchhoff, BA; Smith, SE; Taylor, GT | 1 |
| Bouvier, ML; Gaebel, W; Henning, U; Schmitt, A; Schneider-Axmann, T; von Wilmsdorff, M | 2 |
| Convertini, P; Iacobazzi, F; Iacobazzi, V; Infantino, V; Menga, A; Palmieri, F | 1 |
| Chen, ML | 1 |
| Bitter, I; Gazdag, G; Tolna, J | 1 |
| Du, RH; Fan, Y; Hu, G; Su, CJ; Xu, XQ | 1 |
| Malcolm, P; Pereira, A; Sundram, S; Zhang, B | 1 |
| Blanchet, PJ; Lévesque, D; Mahmoudi, S | 2 |
| Dietrich-Muszalska, A; Kopka, J; Kwiatkowska, A | 1 |
| Bertran-Gonzalez, J; Bonito-Oliva, A; Fisone, G; Girault, JA; Pallottino, S; Valjent, E | 1 |
| Akbarian, S; Bharadwaj, R; Gao, G; Gavin, DP; Jakovcevski, I; Jakovcevski, M; Mitchell, AC; Straubhaar, J | 1 |
| Langhans, W; Meyer, U; Stadlbauer, U | 1 |
| Accordini, S; Barbui, C; Cipriani, A; Girlanda, F; Nosè, M; Purgato, M; Tansella, M | 1 |
| Akbarian, S; Bharadwaj, R; Bunney, WE; Casaccia, P; Dincer, A; Futai, K; Garbett, K; Gardner, PD; Jakovcevski, M; Jiang, Y; Krueger, W; Liu, J; Mao, W; Mirnics, K; Rasmussen, T; Sequeira, A; Tushir, JS; Vawter, MP; Whittle, C | 1 |
| Fijał, K; Nikiforuk, A; Popik, P | 1 |
| Coesmans, M; De Zeeuw, CI; Frens, MA; Koekkoek, SK; Röder, CH; Smit, AE; van der Geest, JN | 1 |
| Bø, CN; Einarson, TR; Hemels, ME; Jensen, R; Piwko, C; Pudas, H; Vicente, C; Zilbershtein, R | 1 |
| Ahmed, J; Chau, DT; Dawson, R; Green, AI; Khokhar, JY; Xie, H | 1 |
| Aoyama, Y; Ikawa, N; Koseki, T; Mamiya, T; Mouri, A; Nabeshima, T; Nagai, T; Narusawa, S; Toriumi, K; Yamada, K | 1 |
| Conway, MW; Francois, J; Gilmour, G; Huxter, J; Ishiwari, K; Li, J; Lowry, JP; Schwarz, AJ; Tricklebank, M | 1 |
| Cairns, MJ; Carroll, A; Gardiner, E; Tooney, PA | 1 |
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| Callahan, PM; Tehim, A; Terry, AV | 1 |
| Kozumplik, O; Mihaljevic-Peles, A; Muck-Seler, D; Nedic Erjavec, G; Nikolac Perkovic, M; Pivac, N; Sagud, M; Uzun, S; Zivkovic, M | 1 |
| Artigas, F; Celada, P; Riga, MS; Soria, G; Tudela, R | 1 |
| Gibson, LE; Green, AI; Mesholam-Gately, RI; Seidman, LJ | 1 |
| Flores, C; Grant, A; Manitt, C | 1 |
| Abílio, VC; Belangero, SI; Bressan, RA; Diana, MC; Gadelha, A; Han, SW; Melaragno, MI; Ota, VK; Santoro, ML; Santos, CM; Silva, PN; Stilhano, RS | 1 |
| Li, M; Liu, X; Sun, T | 1 |
| Davoodi, N; Langlois, X; te Riele, P | 1 |
| Collins, CM; Elliott, JM; Wood, MD | 1 |
| Bay-Richter, C; Heery, DM; Moran, PM; O'Callaghan, MJ; O'Tuathaigh, CM; Waddington, JL | 1 |
| Elmorsy, E; Elsheikha, HM; Elzalabany, LM; Smith, PA | 1 |
| Chaki, S; Hiyoshi, T; Kambe, D; Karasawa, J | 1 |
| Benes, FM; Coyle, JT; Konopaske, GT; Lange, N | 1 |
| Chaki, S; Hikichi, H; Kaku, A; Kambe, D; Karasawa, J; Kawaura, K; Kinoshita, K; Koike, H | 1 |
| De Luca, MA; Di Chiara, G; Perra, V; Serra, GP; Tanda, G; Valentini, V | 1 |
| Fujita, M; Hagino, Y; Hashimoto, M; Ikeda, K; Kasai, S; Kobayashi, K; Meltzer, HY; Setogawa, S; Yamaura, H; Yanagihara, D | 1 |
| Baker, TW; Beninger, RJ; Florczynski, MM | 1 |
| Aiello, R; Citraro, R; De Sarro, G; Leo, A; Pugliese, M; Russo, E | 1 |
| Chen, ML; Tsai, FM; Tsai, TC; Wang, LK; Wu, S | 1 |
| Andreazza, AC; Barakauskas, VE; Barr, AM; Beasley, CL; Fazeli, S; Feresten, A; Shao, L; Wei, V; Wu, CH | 1 |
| De Montis, MG; Ferrari, A; Gambarana, C; Pelliccia, T; Scheggi, S | 1 |
| Praharaj, SK; Sarkhel, S; Singh, N | 1 |
| Foote, M; Graham, K; Qiao, H; Wu, Y; Zhou, Y | 1 |
| Barreiro, EJ; Bosier, B; Fraga, CA; Hermans, E; Menegatti, R; Monteiro do Monte, F; Noël, F; Pompeu, TE | 1 |
| Chau, DT; Dawson, R; Green, AI; Khokhar, JY | 1 |
| Alachkar, A; Belluzzi, JD; Civelli, O; Sanathara, N; Wang, L; Wang, Z | 1 |
| Hiekkalinna, T; Kuja-Panula, J; Kulesskaya, N; Lauri, SE; Liuhanen, J; Paunio, T; Peltola, MA; Piepponen, P; Rauvala, H; Suvisaari, J; Taira, T; Võikar, V | 1 |
| Abilio, VC; Belangero, SI; Bressan, RA; Diana, MC; Moretti, PN; Ota, VK; Santoro, ML; Santos, CM; Spindola, LN; Xavier, G | 1 |
| Bogus, K; Krzystanek, E; Krzystanek, M; Pałasz, A; Wiaderkiewicz, R; Worthington, JJ | 1 |
| Hunt, MJ; Kasicki, S; Olszewski, M; Piasecka, J; Whittington, MA | 1 |
| Antonio, CB; Barreiro, EJ; Betti, AH; Fraga, CA; Herzfeldt, V; Rates, SM | 1 |
| Newland, MC; Shen, AN | 1 |
| Chalmers, DK; Fang, Y; Thomas, T; Yuriev, E | 1 |
| Hall, K; Lewitt, M; Melkersson, K | 1 |
| Akbarian, S; Croxson, PL; Dincer, A; Dracheva, S; Giannaris, EL; Halene, TB; Hemby, SE; Hof, PR; Javidfar, B; Jiang, Y; Kozlenkov, A; Mitchell, AC; Park, R; Roussos, P; Wiseman, J | 1 |
| Hammarlund-Udenaes, M; Jansson, B; König, F; Loryan, I; Melander, E; Payan, M; Svensson, M | 1 |
| Dold, M; Gianatsi, M; Helfer, B; Leucht, S; Nikolakopoulou, A; Salanti, G; Samara, MT | 1 |
| Antczak, A; Górski, P; Karbownik, MS; Kowalczyk, E; Pietras, T; Szemraj, J; Wieteska, Ł | 1 |
| Cai, H; Dang, R; Guo, Y; Jiang, P; Liang, D; Lv, C; Yang, R | 1 |
| Barakauskas, VE; Barr, AM; Beasley, CL; Dwork, AJ; Falkai, P; Honer, WG; Ilievski, B; Mann, JJ; Moradian, A; Morin, GB; Rosoklija, G; Stankov, A | 1 |
| Baymeeva, NV; Burminskiy, DS; Miroshnichenko, II; Morozova, MA; Platova, AI; Potanin, SS | 1 |
| Inada, K; Ishigooka, J; Kawano, M; Kawano, T; Muraoka, H; Oshibuchi, H; Tsutsumi, T; Yamada, M | 1 |
| Hudson, MR; Jones, NC; O'Brien, TJ; Rind, G | 1 |
| Liu, D; Mao, S; Peng, Y; Qin, X; Zhang, R; Zhou, X | 1 |
| Bauer, M; Broccoli, L; Falkai, P; Frodl, T; Hansson, AC; Hirth, N; Malchow, B; Schmitt, A; Sommer, C; Spanagel, R; Steiner, J; Uhrig, S; von Wilmsdorff, M; Zink, M | 1 |
| Barbosa, DS; Bonifácio, KL; Brinholi, FF; Casagrande, R; Farias, CC; Higachi, L; Moreira, EG | 1 |
| Bogus, K; Filipczyk, Ł; Krzystanek, M; Pałasz, A; Rojczyk, E; Wiaderkiewicz, A; Wiaderkiewicz, R; Worthington, J | 1 |
| Jensen, RJ | 1 |
| Jang, CG; Jeong, JH; Kim, HC; Lee, JW; Lee, Y; Lei, XG; Nabeshima, T; Nah, SY; Shin, EJ; Toriumi, K; Tran, TV; Yamada, K | 1 |
| Jaulent, MC; Koutkias, VG; Lillo-Le Louët, A | 1 |
| Khushu, A; Powney, MJ | 1 |
| Ain, R; Drumm, M; Joshi, RS; Panicker, MM; Quadros, R | 1 |
| Chan, HY; Chen, CH; Chen, JJ; Pan, YJ | 1 |
| de Alvarenga, KAF; de Rezende, VB; Romano-Silva, MA; Rosa, DV; Sacramento, EK; Souza, BR | 1 |
| Aznar, S; Blázquez, G; Cañete, T; Corda, MG; Fernández-Teruel, A; Gerbolés, C; Giorgi, O; González-Maeso, J; Oliveras, I; Piludu, MA; Río-Alamos, C; Sampedro-Viana, D; Sánchez-González, A; Tobeña, A | 1 |
| Armstrong, K; Konradi, C; Korade, Ž; Liu, W; Porter, NA; Warren, EB | 1 |
| Barber, S; Cipriani, A; Corsi, M; Olotu, U | 1 |
| Feng, M; Li, M; Sparkman, NL; Sui, N | 1 |
| Ding, X; Hu, G; Li, M; Li, X; Shu, Q; Wu, R | 1 |
| Banerjee, M; Nair, C; Nair, IV; Saradalekshmi, KR; Swathy, B | 2 |
| Alves, ND; Bessa, JM; Correia, JS; Machado-Santos, AR; Mateus-Pinheiro, A; Morais, M; Patrício, P; Pereira, J; Pinto, L; Sousa, N | 1 |
| Baretic, M; Kuzman, MR; Osvatic, MM; Vuk, A | 1 |
| Akar, FY; Buyukokuroglu, ME; Erden, BF; Mutlu, O; Tanyeri, MH; Tanyeri, P; Ulak, G | 1 |
| Aggour, AM; Al-Ghafari, A; Amer, S; Elmorsy, E; Khan, R | 1 |
| Blanchet, PJ; Calon, F; Gasparini, F; Gomez-Mancilla, B; Hernandez, G; Lévesque, C; Lévesque, D; Mahmoudi, S | 1 |
| Abbott, GW; Alachkar, A; Civelli, O; Hamzeh, AR; Lee, SM; Sanathara, N; Wang, L; Wang, Z; Xu, X; Yoshimura, R | 1 |
| Chikama, K; Kajitani, K; Nakabeppu, Y; Tsukamoto, T; Uchimura, N; Yamada, H | 1 |
| Chen, RA; Huang, TL | 1 |
| Aksić, M; Jevtić Dožudić, G; Nikolić, T; Petronijević, M; Petronijević, N; Radonjić, NV; Sopta, J; Stojković, T; Velimirović, M | 1 |
| Bouvier, ML; Falkai, P; Gebicke-Haerter, PJ; Manthey, F; Meisenzahl-Lechner, E; Schmitt, A; Staehlin, O; von Wilmsdorff, M | 1 |
| Honer, WG; Kaufman, K; Kim, DD; Lang, DJ; Procyshyn, RM; Warburton, DER; White, RF; Woodward, ML | 1 |
| Sakamoto, S; Sato, K; Takaki, M; Yamada, N; Yoshimura, B | 1 |
| Kawai, H; Kishimoto, M; Kodama, M; Mizuki, Y; Okahisa, Y; Sakamoto, S; Takaki, M; Yamada, N; Yoshimura, B | 1 |
| Abela, AR; Fletcher, PJ; Lê, AD; Li, Z | 1 |
| Chakravarty, MM; Courcot, B; Devenyi, GA; Elgbeili, G; Giros, B; Guma, E; Lerch, JP; Mathieu, A; Mechawar, N; Rocchetti, J; Tanti, A | 1 |
| Chen, RYY; Reznik, R; Stanford, P | 1 |
| Hanprasertpong, N; Koonrungsesomboon, N; Na Takuathung, M; Teekachunhatean, S | 1 |
| Dal Mas, C; de Almeida Campos, MR; Hayashi, MAF; Marins, LAN; Martins, LG; Monte, GG; Mori, MA; Nani, JV; Tasic, L | 1 |
| Blanchet, PJ; Cyr, M; Diaz, J; Hernandez, G; Lévesque, D; Mahmoudi, S | 1 |
| Lin, JR; Nakagawasai, O; Nemoto, W; Odaira, T; Onogi, H; Sakuma, W; Srivastava, LK; Takahashi, K; Tan-No, K | 1 |
| Bogus, K; Krzystanek, M; Pałasz, A; Suszka-Świtek, A; Wiaderkiewicz, R; Worthington, JJ | 1 |
| De Oliveira, EO; Donahue, TJ; Hillhouse, TM; Porter, JH; Webster, KA | 1 |
| Chakravarty, MM; Courcot, B; Devenyi, GA; Elgbeili, G; Giros, B; Guma, E; Lerch, JP; Mathieu, AP; Mechawar, N; Rocchetti, J; Tanti, A | 1 |
| Jensen, R | 1 |
| Cao, T; Chen, J; Jiang, Y; Waddington, JL; Wang, C; Wang, P; Zhen, X | 1 |
| Görtz, P; Henning, U; Lange-Asschenfeldt, C; Theiss, S | 1 |
| Aggour, AM; Amer, SA; Elmorsy, E; Khalaf, HA; Mahmoud, EM | 1 |
| Foute Nelong, T; Manduca, JD; Perreault, ML; Zonneveld, PM | 1 |
| Kitagawa, K; Nagai, T; Yamada, K | 1 |
| Janas-Kozik, M; Krysta, K; Krzystanek, M; Martyniak, E; Rybakowski, J | 1 |
| Crippa, A; Davis, JM; Leucht, S; Orsini, N; Patel, MX; Siafis, S | 1 |
| Agartz, I; Bohman, H; Curbo, S; Lundberg, M; Mansouri, S; Ögren, SO; Patrone, C | 1 |
| Chen, Y; Gordon, A; Li, B; Tang, W | 1 |
| Bouvier, ML; Fehsel, K; Gaebel, W; Meisenzahl-Lechner, E; Schmitt, A; von Wilmsdorff, M | 2 |
| Isikhan, SY; Samadi, A; Samadi, M; Ulusu, NN; Ziaee, M | 1 |
| Antunes, ASLM; Crunfli, F; de Almeida, V; Martins-de-Souza, D; Reis-de-Oliveira, G; Seabra, G | 1 |
| Alelwani, W; Alnajeebi, A; Babteen, N; Elmorsy, E; Ghulam, J; Kattan, S; Mosad, S | 1 |
| Bhattiprolu, AK; Brzustowicz, LM; Clarke, SG; Crosta, CM; Dudzinski, NR; Firestein, BL; Fu, AY; Hernandez, K; Moore, JC; Paradiso, KG | 1 |
| Gadelha, A; Hayashi, MAF; Juliano, MA; Lee, RS; Mari, JJ; Nani, JV; Sant'Anna, OA; Yonamine, CM | 1 |
| Cepaityte, D; Egberts, T; Kouvelas, D; Leucht, S; Papazisis, G; Siafis, S | 1 |
| Czobor, P; Krakowski, M; Tural, U | 1 |
| Faay, MDM; Sommer, IE | 1 |
| Dziedzicka-Wasylewska, M; Jankowska, U; Kedracka-Krok, S; Prus, G; Skupien-Rabian, B; Swiderska, B | 1 |
| Bonora, M; Castellazzi, M; Giorgi, C; Ingusci, S; Marchi, S; Patergnani, S; Perrone, M; Pinton, P; Previati, M; Pugliatti, M; Simonato, M; Wieckowski, MR; Zucchini, S | 1 |
| Bakker, IM; Kamphuis, J; Schoevers, RA; Smith-Apeldoorn, SY; Touw, DJ; Veraart, JKE; Visser, BAE | 1 |
| Hashimoto, N; Ishikawa, S; Ito, YM; Kusumi, I; Okubo, R; Sato, N; Sawagashira, R; Yamamura, R | 1 |
| Delgado-Sallent, C; Fath, AB; Gener, T; Nebot, P; Puig, MV; Timplalexi, M | 1 |
| Kar, SK | 1 |
| Lawrie, SM | 1 |
| Byeon, SJ; Chung, SJ; Oh, S | 1 |
| Osman, E; Yıldız, M | 1 |
| Arango, C; Leucht, S; Lopez-Morinigo, JD | 1 |
| Guo, Y; Li, T; Peng, X; Sun, X; Zhang, B | 1 |
| Gautam, D; Rorie, D; Sivarao, DV; Ummear Raza, M | 1 |
| Araujo, ARTS; Barroso, M; Gallardo, E; Gameiro, C; Gonçalves, J; Passarinha, LA; Rosado, T; Soares, S | 1 |
| Bastiampillai, T; Chan, SKW; Gregory, KJ; Langmead, CJ; Nair, PC; Tibrewal, P | 1 |
| Artigas, F; Celada, P; Didriksen, M; Paz, V; Riga, MS | 1 |
| Dong, G; Kaibuchi, K; Liao, J; Liu, Y; Mizoguchi, H; Nabeshima, T; Nagai, T; Ozaki, N; Sawahata, M; Wulaer, B; Yamada, K; Zhu, W | 1 |
68 review(s) available for haloperidol and clozapine
| Article | Year |
|---|---|
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Selective optimization of side activities: another way for drug discovery.
Topics: Animals; Biological Availability; Combinatorial Chemistry Techniques; Databases, Factual; Drug Design; Humans; Patents as Topic; Pharmaceutical Preparations; Structure-Activity Relationship | 2004 |
Recent advances in selective alpha1-adrenoreceptor antagonists as antihypertensive agents.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Humans; Hypertension; Molecular Structure; Receptors, Adrenergic, alpha-1; Risk Factors; Stereoisomerism; Structure-Activity Relationship | 2008 |
Polypharmacology - foe or friend?
Topics: Animals; Communicable Diseases; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Polypharmacology; Safety | 2013 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Return of D
Topics: Animals; Drug Discovery; Humans; Ligands; Molecular Targeted Therapy; Neoplasms; Parkinson Disease; Receptors, Dopamine D4; Small Molecule Libraries; Substance-Related Disorders | 2017 |
Influence of the cellular environment on ligand binding kinetics at membrane-bound targets.
Topics: Angiotensin II Type 1 Receptor Blockers; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Humans; Kinetics; Ligands; Protein Binding; Receptor, Angiotensin, Type 1; Receptors, Cell Surface; Signal Transduction | 2017 |
Schizophrenia: synthetic strategies and recent advances in drug design.
Topics: | 2018 |
Practical approaches to evaluating and optimizing brain exposure in early drug discovery.
Topics: Animals; Blood-Brain Barrier; Central Nervous System; Central Nervous System Agents; Drug Delivery Systems; Drug Discovery; Humans; Molecular Structure; Structure-Activity Relationship | 2019 |
Significance of neurochemical parameters in the preclinical evaluation of neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Brain Chemistry; Clozapine; Corpus Striatum; Dopamine; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Haloperidol; Neural Pathways; Neurons; Parasympathetic Nervous System; Postmortem Changes; Substantia Nigra; Tyramine | 1979 |
[Neuroleptics in 1979 (author's transl)].
Topics: Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Psychotic Disorders | 1980 |
Atypical neuroleptics: clozapine and the benzamides in the prevention and treatment of tardive dyskinesia.
Topics: Antipsychotic Agents; Benzamides; Clinical Trials as Topic; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Haloperidol; Humans; Metoclopramide; Prospective Studies; Schizophrenia; Sulpiride; Tiapamil Hydrochloride | 1983 |
Dopamine antagonists in tic-related and psychotic spectrum obsessive compulsive disorder.
Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Clomipramine; Clozapine; Dopamine Antagonists; Drug Therapy, Combination; Female; Fluvoxamine; Haloperidol; Humans; Isoxazoles; Male; Obsessive-Compulsive Disorder; Piperidines; Risperidone; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Tic Disorders; Tourette Syndrome | 1994 |
Brief comparison of the pharmacokinetics and pharmacodynamics of the traditional and newer antipsychotic drugs.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Haloperidol; Humans; Isoxazoles; Piperidines; Risperidone; Time Factors | 1995 |
Clinical use of the newer antipsychotic drugs.
Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Clozapine; Female; Formularies as Topic; Haloperidol; Humans; Isoxazoles; Male; Middle Aged; Piperidines; Risperidone; Schizophrenia | 1995 |
Anatomy and mechanisms of neurotensin-dopamine interactions in the central nervous system.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Cyclic AMP; Dopamine; Haloperidol; Neurotensin; Pyrazoles; Quinolines; Receptors, Dopamine; Receptors, Neurotensin; Schizophrenia; Signal Transduction | 1995 |
Clozapine and noradrenergic function: support for a novel hypothesis for superior efficacy.
Topics: Animals; Brain; Clozapine; Haloperidol; Humans; Norepinephrine; Rats; Receptors, Adrenergic; Schizophrenia; Treatment Outcome | 1994 |
The effects of typical and atypical antipsychotic drugs on neurotensin-containing neurons in the central nervous system.
Topics: Animals; Antipsychotic Agents; Caudate Nucleus; Clozapine; Haloperidol; Humans; Neurotensin; Nucleus Accumbens; Rats; Receptors, Neurotensin; Schizophrenia | 1994 |
Dopamine receptors in the basal ganglia: relevance to Parkinson's disease.
Topics: Basal Ganglia; Basal Ganglia Diseases; Brain; Clozapine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Humans; Levodopa; Male; Neostriatum; Neural Pathways; Parkinson Disease; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 1993 |
Antipsychotic dosing strategies in acute schizophrenia.
Topics: Acute Disease; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Delivery Systems; Haloperidol; Humans; Risperidone; Schizophrenia | 1996 |
Considerations of natural history and pathophysiology in the psychopharmacology of Tourette's syndrome.
Topics: Adolescent; Adult; Age of Onset; Antipsychotic Agents; Child; Clozapine; Disease Progression; Diseases in Twins; Dopamine; Haloperidol; Humans; Obsessive-Compulsive Disorder; Phenotype; Pimozide; Risperidone; Tourette Syndrome; Treatment Outcome | 1996 |
Therapeutic receptor-blocking concentrations of neuroleptics.
Topics: Antipsychotic Agents; Binding, Competitive; Clozapine; Haloperidol; Humans; Receptors, Dopamine | 1995 |
New antipsychotics: the present status.
Topics: Antipsychotic Agents; Binding, Competitive; Clozapine; Dopamine Antagonists; Haloperidol; Humans; Psychotic Disorders; Sulpiride | 1995 |
Effects of chronic neuroleptic treatment on dopamine release: insights from studies using 3-methoxytyramine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Haloperidol; Humans; Neurons; Reproducibility of Results; Time Factors | 1996 |
Mechanisms of action of atypical antipsychotic drugs: a critical analysis.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Behavior, Animal; Biogenic Amines; Brain; Clozapine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Humans; Receptors, Dopamine; Schizophrenia | 1996 |
Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.
Topics: Animals; Antipsychotic Agents; Binding Sites; Clozapine; Haloperidol; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1997 |
The relationship of pharmacology to side effects.
Topics: Akathisia, Drug-Induced; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Haloperidol; Humans; Olanzapine; Parkinson Disease, Secondary; Pirenzepine; Receptors, Neurotransmitter; Seizures; Sleep; Weight Gain | 1997 |
Update on pharmacologic management of OCD: agents and augmentation.
Topics: Clinical Trials as Topic; Clozapine; Dopamine Agents; Drug Therapy, Combination; Female; Fenfluramine; Haloperidol; Humans; Lithium; Middle Aged; Obsessive-Compulsive Disorder; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Treatment Outcome; Tryptophan | 1997 |
Emergency treatment of acute psychosis.
Topics: Acute Disease; Antipsychotic Agents; Benzodiazepines; Clozapine; Decision Trees; Drug Administration Schedule; Emergency Services, Psychiatric; Emergency Treatment; Haloperidol; History, 20th Century; Humans; Lorazepam; Olanzapine; Pirenzepine; Psychotic Disorders; Risperidone | 1998 |
Facilitating compliance with antipsychotic medication.
Topics: Antipsychotic Agents; Clozapine; Cognition; Drug Monitoring; Haloperidol; Health Care Costs; Humans; Patient Compliance; Quality of Life; Risk Factors; Risperidone; Schizophrenia; Treatment Refusal | 1998 |
Cognitive deficit in schizophrenia and its neurochemical basis.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Glutamic Acid; Haloperidol; Humans; N-Methylaspartate; Olanzapine; Pirenzepine; Risperidone; Schizophrenia; Schizophrenic Psychology | 1999 |
[Clinical efficacy of olanzapine].
Topics: Antipsychotic Agents; Benzodiazepines; Binding Sites; Clinical Trials as Topic; Clozapine; Dopamine D2 Receptor Antagonists; Haloperidol; Humans; Olanzapine; Pirenzepine; Risperidone; Schizophrenia; Schizophrenic Psychology; Secondary Prevention; Serotonin | 1999 |
Expected incidence of tardive dyskinesia associated with atypical antipsychotics.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Drug Administration Schedule; Dyskinesia, Drug-Induced; Haloperidol; Humans; Incidence; Molindone; Olanzapine; Pirenzepine; Prospective Studies; Risk Factors; Risperidone; Schizophrenia; Substance Withdrawal Syndrome; Survival Analysis | 2000 |
Rational antipsychotic polypharmacy.
Topics: Antipsychotic Agents; Clozapine; Cytochrome P-450 Enzyme System; Drug Interactions; Haloperidol; Humans; Isoenzymes; Polypharmacy; Psychotic Disorders | 2000 |
Rationale and guidelines for the inpatient treatment of acute psychosis.
Topics: Acute Disease; Antipsychotic Agents; Benzodiazepines; Clozapine; Drug Administration Schedule; Drug Therapy, Combination; Haloperidol; Hospitalization; Hostility; Humans; Olanzapine; Pirenzepine; Practice Guidelines as Topic; Psychomotor Agitation; Psychotic Disorders; Risperidone; Treatment Outcome | 2000 |
Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Dibenzothiepins; Dopamine Antagonists; Drug Monitoring; Haloperidol; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Pirenzepine; Quetiapine Fumarate; Receptors, Dopamine D2; Receptors, Dopamine D4; Risperidone; Schizophrenia; Schizophrenic Psychology; Serotonin Antagonists; Sulpiride; Thiazoles; Treatment Outcome | 2001 |
[Atypical neuroleptics: new approaches to drug therapy of schizophrenic disorders].
Topics: Aged; Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Controlled Clinical Trials as Topic; Dibenzothiazepines; Dibenzothiepins; Haloperidol; Humans; Imidazoles; Indoles; Multicenter Studies as Topic; Olanzapine; Piperazines; Pirenzepine; Placebos; Quetiapine Fumarate; Risperidone; Schizophrenia; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Sulpiride; Thiazoles | 2000 |
Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis.
Topics: Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Dopamine D2 Receptor Antagonists; Haloperidol; Humans; Olanzapine; Pirenzepine; Psychotic Disorders; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Risperidone; Schizophrenia; Terminology as Topic; Tomography, Emission-Computed | 2001 |
Pharmacoeconomic evaluation of clozapine in treatment-resistant schizophrenia: a cost-utility analysis.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Cost-Benefit Analysis; Decision Support Techniques; Economics, Pharmaceutical; Haloperidol; Humans; Quality of Life; Schizophrenia | 2001 |
Safety in treating bipolar disorder.
Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Clozapine; Diabetes Mellitus; Dibenzothiazepines; Dyskinesias; Haloperidol; Humans; Hyperglycemia; Hyperprolactinemia; Olanzapine; Pirenzepine; Quetiapine Fumarate; Risperidone; Thioridazine; Weight Gain | 2003 |
Pharmacogenetics in psychosis.
Topics: Antipsychotic Agents; Clozapine; Cytochrome P-450 Enzyme System; Drug Resistance; Dyskinesia, Drug-Induced; Haloperidol; Humans; Pharmacogenetics; Polymorphism, Genetic; Schizophrenia; Weight Gain | 2003 |
[Late schizophrenia].
Topics: Adult; Age of Onset; Aged; Antipsychotic Agents; Chlorpromazine; Clozapine; Diagnostic and Statistical Manual of Mental Disorders; Electroconvulsive Therapy; Haloperidol; Humans; Middle Aged; Reference Standards; Risk Factors; Risperidone; Schizophrenia; Schizophrenic Psychology | 2003 |
An integrated analysis of acute treatment-emergent extrapyramidal syndrome in patients with schizophrenia during olanzapine clinical trials: comparisons with placebo, haloperidol, risperidone, or clozapine.
Topics: Acute Disease; Adult; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Cholinergic Antagonists; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Olanzapine; Pirenzepine; Placebos; Randomized Controlled Trials as Topic; Retrospective Studies; Risperidone; Schizophrenia | 2003 |
[The appearance of metabolic syndrome in treatment with atypical antipsychotics].
Topics: Adolescent; Adult; Age Factors; Aged; Antipsychotic Agents; Benzodiazepines; Body Mass Index; Body Weight; Clinical Trials as Topic; Clozapine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dibenzothiazepines; Female; Glucose; Haloperidol; Humans; Intellectual Disability; Male; Mental Disorders; Metabolic Syndrome; Middle Aged; Olanzapine; Quetiapine Fumarate; Retrospective Studies; Risk Factors; Risperidone; Schizophrenia; Sex Factors; Time Factors; Weight Gain | 2003 |
[Effect of antipsychotics on glutaminergic neural transmission in the animal model].
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Disease Models, Animal; Haloperidol; Humans; Long-Term Care; Neuronal Plasticity; Neurons; Rats; Receptors, Glutamate; Schizophrenia; Synaptic Transmission | 2004 |
[Psychotropics and weight gain].
Topics: Adolescent; Adult; Amisulpride; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Body Mass Index; Child; Clozapine; Dibenzothiazepines; Double-Blind Method; Female; Fructose; Haloperidol; Humans; Imidazoles; Indoles; Male; Obesity; Olanzapine; Piperazines; Placebos; Psychotropic Drugs; Quetiapine Fumarate; Quinolones; Randomized Controlled Trials as Topic; Risperidone; Socioeconomic Factors; Sulpiride; Thiazoles; Time Factors; Topiramate; Valproic Acid; Weight Gain | 2004 |
Dopamine receptor microdomains involved in molecular recognition and the regulation of drug affinity and function.
Topics: Animals; Arginine; Aspartic Acid; Binding Sites; Clozapine; Dopamine; Dopamine Antagonists; Haloperidol; Humans; Ligands; Protein Structure, Tertiary; Receptors, Dopamine; Risperidone; Serine | 2004 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Cognitive Behavioral Therapy; Dibenzothiepins; Haloperidol; Humans; Olanzapine; Patient Compliance; Perazine; Pimozide; Risperidone; Schizophrenia; Sulpiride | 2003 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Haloperidol; Humans; Olanzapine; Patient Compliance; Perazine; Pimozide; Risperidone; Schizophrenia; Sulpiride | 2004 |
Antipsychotic poisoning in young children: a systematic review.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Child; Child, Preschool; Chlorpromazine; Clozapine; Dibenzothiazepines; Haloperidol; Humans; Infant; Infant, Newborn; Olanzapine; Pimozide; Piperazines; Poisoning; Quetiapine Fumarate; Quinolones; Risperidone | 2005 |
Schizophrenia.
Topics: Amisulpride; Antipsychotic Agents; Chlorpromazine; Clozapine; Cognitive Behavioral Therapy; Dibenzothiepins; Family Therapy; Haloperidol; Humans; Patient Compliance; Risperidone; Schizophrenia; Secondary Prevention; Sulpiride; Thioridazine | 2005 |
[The use of atypical antipsychotics in the long-term care of schizophrenia].
Topics: Amisulpride; Antipsychotic Agents; Aripiprazole; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Cognition Disorders; Drug Tolerance; Dyskinesia, Drug-Induced; Haloperidol; Humans; Olanzapine; Piperazines; Quinolones; Risperidone; Schizophrenia; Sulpiride; Time Factors | 2006 |
The management of psychosis in movement disorder patients.
Topics: Antipsychotic Agents; Clozapine; Haloperidol; Humans; Huntington Disease; Lewy Body Disease; Parkinson Disease; Patient Education as Topic; Psychotic Disorders; Risperidone | 2007 |
Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Disorders of Excessive Somnolence; Haloperidol; Humans; Olanzapine; Prolactin; Schizophrenia, Childhood; Treatment Outcome; Weight Gain | 2008 |
Difficulties in the medical treatment of prolactinoma in a patient with schizophrenia--a case report with a review of the literature.
Topics: Adult; Antipsychotic Agents; Bromocriptine; Clozapine; Dopamine Agonists; Dopamine Antagonists; Drug Antagonism; Female; Haloperidol; Humans; Hyperprolactinemia; Pituitary Neoplasms; Prolactin; Prolactinoma; Schizophrenia | 2008 |
Are second generation antipsychotics a distinct class?
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Cognition Disorders; Haloperidol; Humans; Quality of Life; Schizophrenia | 2008 |
Management of marked liver enzyme increase during olanzapine treatment: a case report and review of the literature.
Topics: Age Factors; Antipsychotic Agents; Benzodiazepines; Chemical and Drug Induced Liver Injury; Clozapine; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Liver; Middle Aged; Olanzapine; Perazine; Risk Factors; Risperidone; Transaminases | 2011 |
[Antipsychotics].
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Drug Discovery; Drug Interactions; Haloperidol; History, 20th Century; History, 21st Century; Humans; Olanzapine | 2011 |
Is rational antipsychotic polytherapy feasible? A selective review.
Topics: Antipsychotic Agents; Aripiprazole; Clozapine; Drug Therapy, Combination; Haloperidol; Humans; Piperazines; Prolactin; Quinolones; Schizophrenia | 2012 |
[Antipsychotic drug combinations in the treatment of schizophrenia. A review of the literature].
Topics: Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Haloperidol; Humans; Methotrimeprazine; Randomized Controlled Trials as Topic; Schizophrenia; Treatment Outcome | 2012 |
Efficacy, Acceptability, and Tolerability of Antipsychotics in Treatment-Resistant Schizophrenia: A Network Meta-analysis.
Topics: Adult; Antipsychotic Agents; Bayes Theorem; Benzodiazepines; Clozapine; Double-Blind Method; Drug Resistance; Female; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Patient Acceptance of Health Care; Randomized Controlled Trials as Topic; Risperidone; Schizophrenia; Single-Blind Method; Treatment Outcome | 2016 |
Haloperidol for long-term aggression in psychosis.
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Clozapine; Drug Administration Schedule; Haloperidol; Humans; Middle Aged; Olanzapine; Psychotic Disorders; Randomized Controlled Trials as Topic; Schizophrenia | 2016 |
Clozapine combined with different antipsychotic drugs for treatment-resistant schizophrenia.
Topics: Adult; Amisulpride; Antipsychotic Agents; Aripiprazole; Clozapine; Dibenzothiazepines; Drug Resistance; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Piperazines; Quetiapine Fumarate; Randomized Controlled Trials as Topic; Risperidone; Schizophrenia; Sulpiride; Thiazoles; Weight Gain | 2017 |
Diabetic ketoacidosis associated with antipsychotic drugs: case reports and a review of literature.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Clozapine; Diabetic Ketoacidosis; Drug Therapy, Combination; Female; Haloperidol; Humans; Insulin; Male; Middle Aged; Olanzapine; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Young Adult | 2017 |
Impact of CYP1A2 genetic polymorphisms on pharmacokinetics of antipsychotic drugs: a systematic review and meta-analysis.
Topics: Adult; Alleles; Antipsychotic Agents; Clozapine; Cytochrome P-450 CYP1A2; Ethnicity; Female; Genotype; Haloperidol; Humans; Male; Middle Aged; Mutation; Olanzapine; Polymorphism, Genetic | 2019 |
Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia.
Topics: Acute Disease; Administration, Oral; Antipsychotic Agents; Aripiprazole; Clozapine; Delayed-Action Preparations; Dose-Response Relationship, Drug; Haloperidol; Humans; Imidazoles; Indoles; Isoxazoles; Lurasidone Hydrochloride; Olanzapine; Paliperidone Palmitate; Piperazines; Piperidines; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Schizophrenic Psychology; Thiazoles; Thiophenes | 2020 |
Pharmacodynamic Interactions Between Ketamine and Psychiatric Medications Used in the Treatment of Depression: A Systematic Review.
Topics: Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Clozapine; Depression; Drug Interactions; Female; Haloperidol; Humans; Ketamine; Lithium; Male; Olanzapine; Psychotropic Drugs; Risperidone; Schizophrenia; Treatment Outcome | 2021 |
Pharmacological Treatment of Early-Onset Schizophrenia: A Critical Review, Evidence-Based Clinical Guidance and Unmet Needs.
Topics: Adolescent; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Haloperidol; Humans; Lurasidone Hydrochloride; Molindone; Olanzapine; Paliperidone Palmitate; Quality of Life; Quetiapine Fumarate; Risperidone; Schizophrenia; Systematic Reviews as Topic | 2022 |
101 trial(s) available for haloperidol and clozapine
| Article | Year |
|---|---|
Tardive dyskinesia during and following treatment with haloperidol, haloperidol + biperiden, thioridazine, and clozapine.
Topics: Aged; Biperiden; Clinical Trials as Topic; Clozapine; Dibenzazepines; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Parkinson Disease, Secondary; Piperidines; Psychotic Disorders; Thioridazine | 1978 |
Paroxysmal EEG activity and psychopathology during the treatment with clozapine.
Topics: Adolescent; Adult; Clinical Trials as Topic; Clozapine; Dibenzazepines; Electroencephalography; Female; Haloperidol; Humans; Male; Schizophrenia; Time Factors | 1979 |
[Anti-psychotic therapy with haloperidol and clozapine].
Topics: Clozapine; Dibenzazepines; Electroencephalography; Haloperidol; Humans; Paranoid Disorders; Sleep | 1979 |
Some methodological considerations for the clinical evaluation of neuroleptics--comparative effects of clozapine and haloperidol on schizophrenics.
Topics: Clozapine; Dibenzazepines; Drug Evaluation; Haloperidol; Humans; Methods; Psychiatric Status Rating Scales; Schizophrenia; Statistics as Topic | 1977 |
Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients.
Topics: Adult; Aged; Basal Ganglia Diseases; Clinical Trials as Topic; Clozapine; Dibenzazepines; Haloperidol; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Movement Disorders; Parkinson Disease, Secondary; Phenylacetates; Schizophrenia | 1975 |
Neuroleptic actions on the thyroid axis: different effects of clozapine and haloperidol.
Topics: Adult; Clozapine; Female; Haloperidol; Humans; Male; Schizophrenia, Paranoid; Schizophrenic Psychology; Thyroid Function Tests; Thyrotropin; Thyrotropin-Releasing Hormone; Thyroxine; Triiodothyronine | 1991 |
Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.
Topics: Adult; Chlorpromazine; Clinical Trials as Topic; Clozapine; Dibenzazepines; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Random Allocation; Schizophrenia | 1988 |
Neuroleptic-induced hypothermia associated with amelioration of psychosis in schizophrenia.
Topics: Adult; Analysis of Variance; Body Temperature; Clozapine; Dibenzazepines; Haloperidol; Humans; Hypothermia; Male; Schizophrenia | 1988 |
High potency neuroleptics and violence in schizophrenics.
Topics: Adult; Akathisia, Drug-Induced; Chlorpromazine; Clozapine; Haloperidol; Humans; Schizophrenia; Schizophrenic Psychology; Verbal Behavior; Violence | 1988 |
Computerized EEG profiles of haloperidol, chlorpromazine, clozapine and placebo in treatment resistant schizophrenia.
Topics: Adolescent; Adult; Alpha Rhythm; Benztropine; Beta Rhythm; Brain Mapping; Chlorpromazine; Clozapine; Delta Rhythm; Dibenzazepines; Double-Blind Method; Electroencephalography; Female; Haloperidol; Humans; Male; Schizophrenia; Signal Processing, Computer-Assisted; Theta Rhythm | 1987 |
Atypical neuroleptics: clozapine and the benzamides in the prevention and treatment of tardive dyskinesia.
Topics: Antipsychotic Agents; Benzamides; Clinical Trials as Topic; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Haloperidol; Humans; Metoclopramide; Prospective Studies; Schizophrenia; Sulpiride; Tiapamil Hydrochloride | 1983 |
Risperidone and clozapine in the treatment of drug-resistant schizophrenia and neuroleptic-induced supersensitivity psychosis.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Resistance; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Isoxazoles; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Psychoses, Substance-Induced; Risperidone; Schizophrenia; Schizophrenic Psychology; Sex Characteristics | 1994 |
Clozapine-induced increase in plasma levels of soluble interleukin-2 receptors.
Topics: Adult; Agranulocytosis; Clozapine; Female; Haloperidol; Humans; Male; Prospective Studies; Receptors, Interleukin-2; Risk Factors; Schizophrenia | 1995 |
Extrapyramidal side effects of clozapine and haloperidol.
Topics: Adult; Akathisia, Drug-Induced; Basal Ganglia Diseases; Clozapine; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Tremor | 1995 |
Clozapine decreases smoking in patients with chronic schizophrenia.
Topics: Adult; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Smoking Cessation | 1995 |
Childhood-onset schizophrenia: an NIMH study in progress.
Topics: Adolescent; Brain; Brain Mapping; Child; Clozapine; Diagnostic Imaging; Double-Blind Method; Female; Follow-Up Studies; Haloperidol; Humans; Male; National Institute of Mental Health (U.S.); Neuropsychological Tests; Pursuit, Smooth; Reaction Time; Schizophrenia, Childhood; United States | 1994 |
Haloperidol and clozapine treatment and their effect on M-chlorophenylpiperazine-mediated responses in schizophrenia: implications for the mechanism of action of clozapine.
Topics: Adrenocorticotropic Hormone; Adult; Clozapine; Haloperidol; Humans; Male; Middle Aged; Piperazines; Prolactin; Radioimmunoassay; Schizophrenia; Schizophrenic Psychology; Serotonin Receptor Agonists | 1993 |
The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performance.
Topics: Adult; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Neuropsychological Tests; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Time Factors | 1994 |
Stability of neurological signs with clozapine treatment.
Topics: Adult; Clozapine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Haloperidol; Humans; Male; Middle Aged; Neurologic Examination; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1994 |
Clozapine in tardive dyskinesia: observations from human and animal model studies.
Topics: Adult; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dyskinesia, Drug-Induced; Female; Follow-Up Studies; Haloperidol; Humans; Male; Rats; Schizophrenia; Treatment Outcome | 1994 |
Plasma clozapine and haloperidol concentrations in adolescents with childhood-onset schizophrenia: association with response.
Topics: Adolescent; Age of Onset; Child; Clozapine; Drug Administration Schedule; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenia, Childhood; Schizophrenic Psychology; Treatment Outcome | 1994 |
The tolerability and efficacy of the atypical neuroleptic remoxipride compared with clozapine and haloperidol in acute schizophrenia.
Topics: Adult; Basal Ganglia Diseases; Clozapine; Cognition; Double-Blind Method; Drug Tolerance; Emotions; Female; Haloperidol; Humans; Male; Neurologic Examination; Psychiatric Status Rating Scales; Remoxipride; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 1994 |
An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia.
Topics: Adolescent; Child; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia, Childhood | 1994 |
Clozapine treatment of outpatients with schizophrenia: outcome and long-term response patterns.
Topics: Adult; Ambulatory Care; Chronic Disease; Clozapine; Double-Blind Method; Female; Follow-Up Studies; Haloperidol; Humans; Male; Patient Readmission; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 1993 |
The effect of clozapine on plasma norepinephrine: relationship to clinical efficacy.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenocorticotropic Hormone; Adult; Analysis of Variance; Clozapine; Dihydroxyphenylalanine; Double-Blind Method; Female; Haloperidol; Hemodynamics; Humans; Hydrocortisone; Male; Naphthols; Norepinephrine; Propylene Glycols; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1994 |
Effects of clozapine on positive and negative symptoms in outpatients with schizophrenia.
Topics: Adult; Ambulatory Care; Chronic Disease; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Sialorrhea; Tachycardia | 1994 |
Clozapine does not elevate serum prolactin levels in healthy men.
Topics: Adult; Antipsychotic Agents; Clozapine; Haloperidol; Humans; Male; Prolactin; Time Factors | 1995 |
Differential effect of clozapine on weight: a controlled study.
Topics: Ambulatory Care; Clozapine; Double-Blind Method; Follow-Up Studies; Haloperidol; Humans; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Weight Gain | 1996 |
Does eosinophilia predict clozapine induced neutropenia?
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Biomarkers; Clozapine; Eosinophilia; Female; Haloperidol; Humans; Male; Middle Aged; Neutropenia; Prospective Studies; Schizophrenia | 1996 |
Childhood-onset schizophrenia. A double-blind clozapine-haloperidol comparison.
Topics: Adolescent; Age Factors; Age of Onset; Child; Child, Preschool; Clozapine; Double-Blind Method; Drug Administration Schedule; Haloperidol; Humans; Neutropenia; Psychiatric Status Rating Scales; Schizophrenia, Childhood; Seizures; Severity of Illness Index; Treatment Outcome | 1996 |
Weight gain induced by clozapine.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Male; Schizophrenia; Weight Gain | 1995 |
Predictive value of eosinophilia for neutropenia during clozapine treatment.
Topics: Adult; Clozapine; Double-Blind Method; Eosinophilia; Female; Haloperidol; Humans; Incidence; Male; Neutropenia; Probability; Retrospective Studies; Schizophrenia | 1996 |
Hepatotoxicity of clozapine.
Topics: Adult; Alanine Transaminase; Antipsychotic Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clozapine; Enzymes; Female; Haloperidol; Humans; Liver Function Tests; Male; Prospective Studies; Sex Characteristics | 1997 |
Short and long-term immunosuppressive effects of clozapine and haloperidol.
Topics: Adult; Aged; Animals; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Middle Aged; Schizophrenia; Time Factors | 1997 |
A comparison of clozapine and haloperidol in hospitalized patients with refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Costs and Cost Analysis; Cross-Over Studies; Double-Blind Method; Female; Haloperidol; Hospitalization; Humans; Length of Stay; Male; Patient Compliance; Quality of Life; Schizophrenia | 1997 |
Effects of clozapine on plasma catecholamines and relation to treatment response in schizophrenia: a within-subject comparison with haloperidol.
Topics: Aged; Analysis of Variance; Antipsychotic Agents; Clozapine; Haloperidol; Homovanillic Acid; Humans; Hydrocortisone; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Prolactin; Psychotic Disorders; Schizophrenia | 1997 |
IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol.
Topics: Adult; Antipsychotic Agents; Benzamides; Clozapine; Dibenzothiazepines; Dopamine Antagonists; Female; Haloperidol; Humans; Male; Middle Aged; Neostriatum; Psychotic Disorders; Pyrrolidines; Quetiapine Fumarate; Receptors, Dopamine D2; Schizophrenia; Tomography, Emission-Computed, Single-Photon | 1997 |
Differential effect of haloperidol and clozapine on plasma homovanillic acid in elderly schizophrenic patients with or without tardive dyskinesia.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Clozapine; Dyskinesia, Drug-Induced; Female; Haloperidol; Homovanillic Acid; Humans; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia | 1998 |
Topographic analysis of EEG photic driving in patients with schizophrenia following clozapine treatment.
Topics: Adult; Antipsychotic Agents; Clozapine; Cross-Over Studies; Double-Blind Method; Electroencephalography; Evoked Potentials, Visual; Female; Haloperidol; Humans; Male; Schizophrenia | 1998 |
Positive and negative symptom response to clozapine in schizophrenic patients with and without the deficit syndrome.
Topics: Adult; Age of Onset; Antipsychotic Agents; Clozapine; Double-Blind Method; Employment; Female; Follow-Up Studies; Haloperidol; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Quality of Life; Schizophrenia; Schizophrenic Psychology; Social Adjustment; Treatment Outcome | 1998 |
Does participation in psychosocial treatment augment the benefit of clozapine? Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.
Topics: Adult; Antipsychotic Agents; Case Management; Clozapine; Cross-Over Studies; Double-Blind Method; Female; Haloperidol; Hospitalization; Hospitals, Veterans; Humans; Male; Models, Statistical; Outcome Assessment, Health Care; Patient Acceptance of Health Care; Patient Participation; Psychotherapy; Quality of Life; Rehabilitation, Vocational; Schizophrenia; Social Support | 1998 |
Cardiovascular autonomic reactivity in schizophrenics under neuroleptic treatment: A potential predictor of short-term outcome?
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Autonomic Nervous System; Blood Pressure; Cardiovascular System; Chi-Square Distribution; Clozapine; Female; Haloperidol; Hand Strength; Heart Rate; Humans; Male; Middle Aged; Multivariate Analysis; Schizophrenia; Treatment Outcome; Valsalva Maneuver | 1998 |
Predictors of differential response to clozapine and haloperidol. Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.
Topics: Adult; Age Factors; Antipsychotic Agents; Clozapine; Double-Blind Method; Drug Resistance; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Quality of Life; Racial Groups; Schizophrenia; Schizophrenic Psychology; Social Support; Treatment Outcome; United States; United States Department of Veterans Affairs | 1998 |
Effects of clozapine on auditory event-related potentials in schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Double-Blind Method; Event-Related Potentials, P300; Evoked Potentials, Auditory; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Psychomotor Performance; Schizophrenia; Schizophrenic Psychology | 1998 |
Multiple outcome assessment in a study of the cost-effectiveness of clozapine in the treatment of refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.
Topics: Clozapine; Cost-Benefit Analysis; Double-Blind Method; Drug Costs; Haloperidol; Hospital Costs; Hospitals, Veterans; Humans; Long-Term Care; Outcome Assessment, Health Care; Patient Admission; Prospective Studies; Psychiatric Status Rating Scales; Quality-Adjusted Life Years; Schizophrenia | 1998 |
Impact of clozapine on negative symptoms and on the deficit syndrome in refractory schizophrenia. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.
Topics: Analysis of Variance; Clozapine; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Haloperidol; Hospitalization; Humans; Prospective Studies; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Treatment Outcome | 1999 |
In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol.
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Benzamides; Benzodiazepines; Clozapine; Contrast Media; Corpus Striatum; Female; Haloperidol; Humans; Iodine Radioisotopes; Male; Middle Aged; Olanzapine; Pirenzepine; Pyrrolidines; Receptors, Dopamine D2; Schizophrenia; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 1999 |
Cost-effectiveness of clozapine in patients with high and low levels of hospital use. Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Cost-Benefit Analysis; Cross-Over Studies; Drug Costs; Female; Haloperidol; Health Care Costs; Hospitalization; Humans; Length of Stay; Male; Middle Aged; Research Design; Schizophrenia; Treatment Outcome | 1999 |
Novel antipsychotics: comparison of weight gain liabilities.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Haloperidol; Humans; Imidazoles; Indoles; Male; Obesity; Olanzapine; Pirenzepine; Placebos; Retrospective Studies; Risperidone; Schizophrenia; Weight Gain | 1999 |
Double-blind study of clozapine dose response in chronic schizophrenia.
Topics: Antipsychotic Agents; Brief Psychiatric Rating Scale; Clozapine; Cross-Sectional Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Haloperidol; Humans; Male; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 1999 |
Elevated prolactin in pediatric patients on typical and atypical antipsychotics.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Child; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Olanzapine; Pirenzepine; Prolactin; Sex Factors | 1999 |
How long to wait for a response to clozapine: a comparison of time course of response to clozapine and conventional antipsychotic medication in refractory schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Cross-Over Studies; Double-Blind Method; Female; Haloperidol; Humans; Male; Prospective Studies; Reaction Time; Schizophrenia; Time Factors | 1999 |
Expected incidence of tardive dyskinesia associated with atypical antipsychotics.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Drug Administration Schedule; Dyskinesia, Drug-Induced; Haloperidol; Humans; Incidence; Molindone; Olanzapine; Pirenzepine; Prospective Studies; Risk Factors; Risperidone; Schizophrenia; Substance Withdrawal Syndrome; Survival Analysis | 2000 |
Medication continuation and compliance: a comparison of patients treated with clozapine and haloperidol.
Topics: Adult; Antipsychotic Agents; Black or African American; Clozapine; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Haloperidol; Humans; Male; Patient Compliance; Patient Dropouts; Regression Analysis; Schizophrenia; Treatment Outcome; Treatment Refusal; Weight Gain | 2000 |
Cost-effectiveness of clozapine compared with conventional antipsychotic medication for patients in state hospitals.
Topics: Adult; Antipsychotic Agents; Clozapine; Connecticut; Cost-Benefit Analysis; Drug Costs; Economics, Pharmaceutical; Female; Haloperidol; Health Care Costs; Hospitals, Psychiatric; Hospitals, State; Humans; Male; Psychiatric Status Rating Scales; Quality of Life; Schizophrenia; Treatment Outcome | 2000 |
Clinical and psychopharmacologic factors influencing family burden in refractory schizophrenia. The Department of Veterans Affairs Cooperative Study Group on Clozapine in Refractory Schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Family Health; Female; Haloperidol; Health Status; Humans; Interpersonal Relations; Male; Quality of Life; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Social Support | 2000 |
Detecting improvement in quality of life and symptomatology in schizophrenia.
Topics: Adult; Clozapine; Double-Blind Method; Female; Follow-Up Studies; Haloperidol; Hospitalization; Humans; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Psychometrics; Quality of Life; Schizophrenia; Schizophrenic Psychology; Veterans | 2001 |
Comparison of clozapine and haloperidol on some autonomic and psychomotor functions, and on serum prolactin concentration, in healthy subjects.
Topics: Adult; Antipsychotic Agents; Anxiety; Attention; Autonomic Nervous System; Blood Pressure; Clozapine; Double-Blind Method; Haloperidol; Heart Rate; Humans; Male; Middle Aged; Neurosecretory Systems; Prolactin; Psychomotor Performance; Pupil; Salivation; Time Factors | 2001 |
Clozapine and haloperidol in moderately refractory schizophrenia: a 6-month randomized and double-blind comparison.
Topics: Adult; Anorexia; Antipsychotic Agents; Brief Psychiatric Rating Scale; Clozapine; Dizziness; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Xerostomia | 2001 |
Clozapine enhances neurocognition and clinical symptomatology more than standard neuroleptics.
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Clozapine; Cognition; Cognition Disorders; Cross-Over Studies; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Neuropsychological Tests; Psychiatric Status Rating Scales; Schizophrenia; Wechsler Scales | 2001 |
Effects of clozapine, olanzapine, risperidone, and haloperidol on hostility among patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Double-Blind Method; Emotions; Female; Haloperidol; Hostility; Humans; Linear Models; Male; Olanzapine; Pirenzepine; Prospective Studies; Psychotic Disorders; Risperidone; Schizophrenia; Schizophrenic Psychology; Statistics, Nonparametric; Survival Analysis | 2001 |
Neuroendocrine responsivities of the pituitary dopamine system in male schizophrenic patients during treatment with clozapine, olanzapine, risperidone, sulpiride, or haloperidol.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Pirenzepine; Pituitary Gland; Prolactin; Receptors, Dopamine D2; Risperidone; Schizophrenia; Sulpiride | 2001 |
Effects of haloperidol and clozapine on prepulse inhibition of the acoustic startle response and the N1/P2 auditory evoked potential in man.
Topics: Acoustic Stimulation; Adolescent; Adult; Affect; Antipsychotic Agents; Clozapine; Double-Blind Method; Electromyography; Evoked Potentials, Auditory; Flicker Fusion; Haloperidol; Hemodynamics; Humans; Male; Oculomotor Muscles; Prolactin; Reflex, Startle; Salivation | 2001 |
Clozapine, olanzapine, risperidone, and haloperidol in the treatment of patients with chronic schizophrenia and schizoaffective disorder.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Patient Admission; Pirenzepine; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2002 |
Clinical predictors of response to clozapine treatment in ambulatory patients with schizophrenia.
Topics: Adult; Ambulatory Care; Antipsychotic Agents; Basal Ganglia Diseases; Brief Psychiatric Rating Scale; Chronic Disease; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Probability; Psychiatric Status Rating Scales; Schizophrenia; Treatment Outcome | 2002 |
Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition; Double-Blind Method; Female; Haloperidol; Humans; Male; Neuropsychological Tests; Olanzapine; Pirenzepine; Psychotic Disorders; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2002 |
Serum glucose and lipid changes during the course of clozapine treatment: the effect of concurrent beta-adrenergic antagonist treatment.
Topics: Adrenergic beta-Antagonists; Adult; Analysis of Variance; Antipsychotic Agents; Atenolol; Blood Glucose; Clozapine; Double-Blind Method; Drug Therapy, Combination; Female; Haloperidol; Humans; Lipids; Male; Propranolol; Psychotic Disorders; Schizophrenia; Statistics, Nonparametric; Weight Gain | 2003 |
Classical and atypical neuroleptics, and bone mineral density, in patients with schizophrenia.
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Bone Density; Clopenthixol; Clozapine; Female; Fluphenazine; Haloperidol; Humans; Male; Olanzapine; Pirenzepine; Risperidone; Schizophrenia | 2002 |
Augmentation of clozapine partial responders with conventional antipsychotics.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Synergism; Fluphenazine; Haloperidol; Humans; Middle Aged; Schizophrenia; Treatment Outcome | 2003 |
Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics.
Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Cholesterol; Clozapine; Double-Blind Method; Drug Administration Schedule; Female; Haloperidol; Hospitalization; Humans; Hypercholesterolemia; Hyperglycemia; Male; Middle Aged; Olanzapine; Pirenzepine; Prospective Studies; Psychotic Disorders; Risperidone; Schizophrenia; Weight Gain | 2003 |
The relationship of clozapine and haloperidol treatment response to prefrontal, hippocampal, and caudate brain volumes.
Topics: Adult; Ambulatory Care; Antipsychotic Agents; Brief Psychiatric Rating Scale; Caudate Nucleus; Clozapine; Double-Blind Method; Female; Functional Laterality; Haloperidol; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Prefrontal Cortex; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2003 |
Changing environments and alternative perspectives in evaluating the cost-effectiveness of new antipsychotic drugs.
Topics: Adult; Antipsychotic Agents; Clozapine; Cost-Benefit Analysis; Female; Haloperidol; Humans; Male; Schizophrenia; Surveys and Questionnaires; Veterans | 2003 |
The effects of clozapine versus haloperidol on measures of impulsive aggression and suicidality in chronic schizophrenia patients: an open, nonrandomized, 6-month study.
Topics: Adolescent; Adult; Aggression; Antipsychotic Agents; Chronic Disease; Clozapine; Diagnostic and Statistical Manual of Mental Disorders; Disruptive, Impulse Control, and Conduct Disorders; Drug Administration Schedule; Female; Haloperidol; Humans; Male; Middle Aged; Schizophrenia; Suicide, Attempted | 2003 |
Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex.
Topics: Acoustic Stimulation; Adult; Antipsychotic Agents; Auditory Perception; Brain Mapping; Clozapine; Female; Frontal Lobe; Gyrus Cinguli; Haloperidol; Humans; Male; Oxygen Radioisotopes; Psychomotor Performance; Reaction Time; Regional Blood Flow; Schizophrenia; Tomography, Emission-Computed | 2004 |
A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.
Topics: Adolescent; Adult; Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Benzodiazepines; Biotransformation; Clozapine; Dibenzothiazepines; Electrocardiography; Female; Haloperidol; Heart Conduction System; Humans; Long QT Syndrome; Male; Middle Aged; Olanzapine; Quetiapine Fumarate; Risperidone; Thioridazine | 2004 |
Discrete state analysis for interpretation of data from clinical trials.
Topics: Antipsychotic Agents; Clinical Trials as Topic; Clozapine; Cluster Analysis; Cross-Sectional Studies; Data Interpretation, Statistical; Double-Blind Method; Haloperidol; Humans; Models, Statistical; Outcome and Process Assessment, Health Care; Principal Component Analysis; Randomized Controlled Trials as Topic; Schizophrenia; Treatment Outcome; United States; United States Department of Veterans Affairs | 2004 |
Prolactin levels in schizophrenia and schizoaffective disorder patients treated with clozapine, olanzapine, risperidone, or haloperidol.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Haloperidol; Humans; Male; Olanzapine; Prolactin; Risperidone; Schizophrenia; Sexual Dysfunction, Physiological | 2004 |
Effects of atypical antipsychotics on the syndromal profile in treatment-resistant schizophrenia.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Factor Analysis, Statistical; Female; Haloperidol; Humans; Male; Olanzapine; Prospective Studies; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2004 |
Overt aggression and psychotic symptoms in patients with schizophrenia treated with clozapine, olanzapine, risperidone, or haloperidol.
Topics: Aggression; Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Haloperidol; Humans; Olanzapine; Psychiatric Status Rating Scales; Psychometrics; Psychotic Disorders; Risperidone; Schizophrenia; Schizophrenic Psychology | 2004 |
Efficacy of clozapine, olanzapine, risperidone, and haloperidol in schizophrenia and schizoaffective disorder assessed with nurses observation scale for inpatient evaluation.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Haloperidol; Humans; Nursing Assessment; Olanzapine; Prospective Studies; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2005 |
Does clozapine decrease smoking?
Topics: Adult; Antipsychotic Agents; Biomarkers; Clozapine; Cotinine; Double-Blind Method; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Sex Characteristics; Smoking; Time Factors | 2005 |
Likelihood methods for treatment noncompliance and subsequent nonresponse in randomized trials.
Topics: Algorithms; Antipsychotic Agents; Biometry; Clozapine; Computer Simulation; Data Interpretation, Statistical; Haloperidol; Humans; Likelihood Functions; Models, Statistical; Odds Ratio; Patient Compliance; Randomized Controlled Trials as Topic; Reproducibility of Results; Schizophrenia; Sensitivity and Specificity; Statistics as Topic; Treatment Outcome | 2005 |
Effectiveness of clozapine, olanzapine, quetiapine, risperidone, and haloperidol monotherapy in reducing hostile and aggressive behavior in outpatients treated for schizophrenia: a prospective naturalistic study (IC-SOHO).
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Clozapine; Cohort Studies; Dibenzothiazepines; Female; Haloperidol; Hostility; Humans; Male; Olanzapine; Outpatients; Prospective Studies; Quetiapine Fumarate; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2005 |
Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine.
Topics: Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Clozapine; Female; Haloperidol; Humans; Male; Middle Aged; Schizophrenia; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2006 |
Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder.
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Olanzapine; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Treatment Outcome; Violence | 2006 |
Neuroleptic treatment effect on mitochondrial electron transport chain: peripheral blood mononuclear cells analysis in psychotic patients.
Topics: Adult; Antipsychotic Agents; Clozapine; Cross-Sectional Studies; Electron Transport; Electron Transport Complex I; Female; Haloperidol; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Mitochondria; Neuroleptic Malignant Syndrome; Risperidone; Schizophrenia | 2007 |
Decreased serum neurotrophin 3 in chronically medicated schizophrenic males.
Topics: Adult; Antipsychotic Agents; Clozapine; Diagnostic and Statistical Manual of Mental Disorders; Enzyme-Linked Immunosorbent Assay; Haloperidol; Humans; Longitudinal Studies; Male; Middle Aged; Neurotrophin 3; Phlebotomy; Risperidone; Schizophrenia | 2008 |
Atypical antipsychotics, neurocognitive deficits, and aggression in schizophrenic patients.
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Violence | 2008 |
Weight gain, metabolic parameters, and the impact of race in aggressive inpatients randomized to double-blind clozapine, olanzapine or haloperidol.
Topics: Adult; Aggression; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Body Mass Index; Cholesterol; Clozapine; Double-Blind Method; Ethnicity; Female; Haloperidol; Humans; Inpatients; Lipid Metabolism; Male; Middle Aged; Olanzapine; Prospective Studies; Schizophrenia; Weight Gain; Young Adult | 2009 |
The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.
Topics: Antipsychotic Agents; Black or African American; Carrier Proteins; Clozapine; Double Bind Interaction; Dysbindin; Dystrophin-Associated Proteins; Genetic Variation; Genotype; Haloperidol; Haplotypes; Humans; Schizophrenia; Treatment Outcome; White People | 2009 |
Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparison.
Topics: Adult; Amisulpride; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Cognition Disorders; Female; Follow-Up Studies; Haloperidol; Humans; Male; Neuropsychological Tests; Olanzapine; Perphenazine; Piperazines; Prospective Studies; Psychotic Disorders; Risperidone; Severity of Illness Index; Sulpiride; Thiazoles | 2009 |
Rationale and design of an independent randomised controlled trial evaluating the effectiveness of aripiprazole or haloperidol in combination with clozapine for treatment-resistant schizophrenia.
Topics: Antipsychotic Agents; Aripiprazole; Clinical Protocols; Clozapine; Drug Resistance; Drug Therapy, Combination; Government Regulation; Haloperidol; Humans; Italy; Piperazines; Prospective Studies; Quinolones; Research Design; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2009 |
Effectiveness of clozapine, haloperidol and chlorpromazine in schizophrenia during a five-year period.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Drug Administration Schedule; Female; Haloperidol; Humans; Male; Prospective Studies; Schizophrenia; Time Factors; Treatment Outcome | 2009 |
Correlation of adenosinergic activity with superior efficacy of clozapine for treatment of chronic schizophrenia: a double blind randomised trial.
Topics: Adenosine; Adenosine Deaminase; Adult; Chronic Disease; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Prospective Studies; Risperidone; Schizophrenia; Treatment Outcome; Young Adult | 2011 |
Aripiprazole versus haloperidol in combination with clozapine for treatment-resistant schizophrenia in routine clinical care: a randomized, controlled trial.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Brief Psychiatric Rating Scale; Clozapine; Drug Resistance; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Piperazines; Quinolones; Schizophrenia | 2011 |
Cholesterol and cognition in schizophrenia: a double-blind study of patients randomized to clozapine, olanzapine and haloperidol.
Topics: Adolescent; Adult; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Blood Glucose; Body Weight; Cholesterol; Clozapine; Cognition Disorders; Double-Blind Method; Female; Follow-Up Studies; Haloperidol; Humans; Male; Middle Aged; Neuropsychological Tests; Olanzapine; Prospective Studies; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Triglycerides; Young Adult | 2011 |
Executive function predicts response to antiaggression treatment in schizophrenia: a randomized controlled trial.
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Clozapine; Executive Function; Female; Haloperidol; Humans; Male; Olanzapine; Predictive Value of Tests; Psychological Tests; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology | 2012 |
Social cognition and visual perception in schizophrenia inpatients treated with first-and second-generation antipsychotic drugs.
Topics: Adolescent; Adult; Affect; Antipsychotic Agents; Awareness; Benzodiazepines; Case-Control Studies; Clozapine; Cues; Discrimination, Psychological; Emotions; Facial Expression; Female; Haloperidol; Hospitalization; Humans; Linear Models; Male; Middle Aged; Olanzapine; Perphenazine; Psychotic Disorders; Retina; Schizophrenia; Schizophrenic Psychology; Social Behavior; Social Perception; Speech Perception; Theory of Mind; Visual Perception; Young Adult | 2012 |
Aripiprazole versus haloperidol in combination with clozapine for treatment-resistant schizophrenia: a 12-month, randomized, naturalistic trial.
Topics: Antipsychotic Agents; Aripiprazole; Clozapine; Disease-Free Survival; Drug Resistance; Drug Therapy, Combination; Haloperidol; Humans; Italy; Kaplan-Meier Estimate; Linear Models; Multivariate Analysis; Piperazines; Proportional Hazards Models; Psychiatric Status Rating Scales; Quinolones; Schizophrenia; Schizophrenic Psychology; Time Factors; Treatment Outcome | 2013 |
Depression and impulsivity as pathways to violence: implications for antiaggressive treatment.
Topics: Adult; Aggression; Antipsychotic Agents; Benzodiazepines; Clozapine; Depression; Double-Blind Method; Female; Haloperidol; Humans; Impulsive Behavior; Male; Middle Aged; Olanzapine; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Violence; Young Adult | 2014 |
The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol.
Topics: Adult; Antipsychotic Agents; Clozapine; Conduct Disorder; Double-Blind Method; Female; Haloperidol; Humans; Male; Olanzapine; Psychiatric Status Rating Scales; Schizophrenia; Violence | 2021 |
1363 other study(ies) available for haloperidol and clozapine
| Article | Year |
|---|---|
5-Chloro-2-phenyl-1-benzo[b]thiophene-3-alkanimines, potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Cattle; Dextroamphetamine; Dopamine; Dopamine Antagonists; Haloperidol; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Rats; Receptors, Dopamine; Thiophenes | 1978 |
Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antipsychotic Agents; Avoidance Learning; Brain; Clozapine; Corpus Striatum; Dextroamphetamine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Mice; Rats | 1978 |
Pyrrole mannich bases as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Male; Mannich Bases; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship | 1992 |
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles.
Topics: Animals; Antipsychotic Agents; Dopamine Antagonists; Imidazoles; Indoles; Male; Mice; Piperazines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 1992 |
3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Mice; Rats; Receptors, Dopamine; Receptors, Serotonin; Schizophrenia; Substrate Specificity; Tetrahydronaphthalenes; Thiazoles; Thiazolidines | 1992 |
Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.
Topics: Animals; Chlorides; CHO Cells; Cricetinae; Dopamine; Dopamine Agents; Dopamine Antagonists; Guanylyl Imidodiphosphate; Humans; Lithium; Lithium Chloride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sodium Chloride; Sulpiride; Transfection | 1992 |
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Molecular Structure; Piperazines; Pyrimidines; Rats; Receptors, Dopamine D2; Stereoisomerism; Stereotyped Behavior | 1992 |
Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.
Topics: Amides; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Catalepsy; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Imides; Male; Mice; Molecular Structure; Motor Activity; Phthalimides; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Self Stimulation; Social Behavior; Spiro Compounds; Stereotyped Behavior; Thiazoles | 1991 |
1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Behavior, Animal; Dopamine Antagonists; Haloperidol; Ketanserin; Locomotion; Male; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Blotting, Northern; Brain; Cell Line; Cell Membrane; Cloning, Molecular; Dopamine; Humans; Kinetics; Molecular Sequence Data; Molecular Weight; Oligonucleotide Probes; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D5; RNA, Messenger; Sequence Homology, Nucleic Acid; Transfection | 1991 |
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
Topics: Amino Acid Sequence; Animals; Antipsychotic Agents; Base Sequence; Brain Chemistry; Cell Line; Cloning, Molecular; Cricetinae; DNA; DNA Restriction Enzymes; Dopamine; Guanylyl Imidodiphosphate; Molecular Sequence Data; Nucleic Acid Hybridization; Polymerase Chain Reaction; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sequence Homology, Nucleic Acid; Tissue Distribution | 1990 |
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
5-Piperazinylalkyl-2(3H)-oxazolones with neuroleptic activity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Catalepsy; Dogs; Indicators and Reagents; Male; Mice; Molecular Structure; Motor Activity; Muscles; Oxazoles; Oxazolone; Piperazines; Rats; Stereotyped Behavior; Structure-Activity Relationship | 1989 |
Examination of a series of 8-[3-[bis(4-fluorophenyl)amino]propyl]-1-aryl-1,3,8- triazaspiro[4.5]decan-4-ones as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Cebus; Chemical Phenomena; Chemistry; Haloperidol; Hypothalamus; Male; Mice; Motor Activity; Rats; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Muscarinic; Saimiri; Spiro Compounds; Structure-Activity Relationship | 1985 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Catalepsy; Cerebral Cortex; Corpus Striatum; Isoxazoles; Male; Models, Molecular; Norepinephrine; Oxazoles; Physostigmine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sleep; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles | 1986 |
(5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Ataxia; Avoidance Learning; Brain; Cebus; Chemical Phenomena; Chemistry; Dopamine; Male; Mice; Motor Activity; Movement Disorders; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, Dopamine; Saimiri | 1986 |
Psychotropic agents: synthesis and antipsychotic activity of substituted beta-carbolines.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Carbolines; Male; Mice; Rats; Stereotyped Behavior; Structure-Activity Relationship | 1987 |
Antipsychotic activity of substituted gamma-carbolines.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Carbolines; Male; Mice; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Structure-Activity Relationship | 1987 |
Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Cebus; Imidazoles; Mice; Motor Activity; Pyrazoles; Pyrimidines; Rats; Receptors, Dopamine; Structure-Activity Relationship | 1988 |
Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines.
Topics: Animals; Carbolines; Chemical Phenomena; Chemistry; Dextroamphetamine; Male; Mice; Molecular Conformation; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship | 1986 |
Functional group contributions to drug-receptor interactions.
Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship | 1984 |
4-Piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as potential neuroleptics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Body Temperature; Catalepsy; Humans; Lethal Dose 50; Mice; Piperazines; Rats; Structure-Activity Relationship | 1980 |
10-Piperazinyl-4H-theino[3,2-b][1,5]- and -[3,4-b][1,5]benzodiazepines as potential neuroleptics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Body Temperature; Catalepsy; Humans; Lethal Dose 50; Mice; Piperazines; Rats | 1980 |
Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Cattle; Central Nervous System; Dopamine; Dopamine Antagonists; Haloperidol; In Vitro Techniques; Isoquinolines; Male; Mice; Rats; Receptors, Dopamine | 1980 |
Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Brain; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Parasympathetic Nervous System; Physostigmine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Muscarinic; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; X-Ray Diffraction | 1982 |
Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Buspirone; Corpus Striatum; Kinetics; Male; Models, Molecular; Molecular Conformation; Piperazines; Pyrimidines; Rats; Receptors, Dopamine; Spiperone; Structure-Activity Relationship | 1983 |
2-Amino-6-chloro-4-(N-methylpiperazino)pyrimidines, inhibitors of spiroperidol binding.
Topics: Animals; Binding, Competitive; Butyrophenones; Chemical Phenomena; Chemistry; Clozapine; Corpus Striatum; Crystallography; Haloperidol; In Vitro Techniques; Molecular Conformation; Piperazines; Pyrimidines; Rats; Receptors, Dopamine; Spiperone; X-Ray Diffraction | 1982 |
Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists.
Topics: Animals; Dimethylamines; Dopamine Antagonists; Ear; In Vitro Techniques; Male; Piperazines; Rabbits; Receptors, Dopamine; Structure-Activity Relationship; Vasoconstriction | 1981 |
Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists.
Topics: Animals; Avoidance Learning; Behavior, Animal; Chemical Phenomena; Chemistry; Dopamine Antagonists; Isoquinolines; Rats; Thiophenes | 1981 |
Piperazinylalkyl heterocycles as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Azepines; Azocines; Cell Membrane; Cerebral Cortex; Conditioning, Psychological; Drug Stability; Furans; Hydrogen-Ion Concentration; Male; Molecular Structure; Piperazines; Piperidones; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship | 1995 |
N-aryl-N'-benzylpiperazines as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Cell Membrane; Cerebral Cortex; Conditioning, Psychological; Male; Molecular Structure; Piperazines; Piperidones; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship | 1995 |
3-[[(Aryloxy)alkyl]piperidinyl]-1,2-benzisoxazoles as D2/5-HT2 antagonists with potential atypical antipsychotic activity: antipsychotic profile of iloperidone (HP 873).
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dopamine Antagonists; In Vitro Techniques; Isoxazoles; Male; Piperidines; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 1995 |
2-Phenyl-4-(aminomethyl)imidazoles as potential antipsychotic agents. Synthesis and dopamine D2 receptor binding.
Topics: Animals; Antipsychotic Agents; Chlorocebus aethiops; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary; Imidazoles; Protein Binding; Receptors, Dopamine D2; Structure-Activity Relationship | 1995 |
Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics.
Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Drug Design; Indoles; Receptors, Dopamine D2; Receptors, Serotonin; Stereoisomerism | 1993 |
Pyridobenzoxazepine and pyridobenzothiazepine derivatives as potential central nervous system agents: synthesis and neurochemical study.
Topics: Animals; Antipsychotic Agents; Binding Sites; Dogs; Oxazepines; Pyridines; Rats; Receptors, Dopamine; Receptors, Muscarinic; Receptors, Serotonin; Structure-Activity Relationship; Thiazepines | 1994 |
Characterization of the human dopamine D3 receptor expressed in transfected cell lines.
Topics: Animals; Arachidonic Acid; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Inositol Phosphates; Mice; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Transfection | 1994 |
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.
Topics: Animals; Antipsychotic Agents; Cell Line; Molecular Structure; Rats; Receptors, Serotonin | 1994 |
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.
Topics: Animals; Antipsychotic Agents; Dogs; Humans; Molecular Structure; Piperazines; Raclopride; Rats; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Salicylamides | 1994 |
Benzisoxazole- and benzisothiazole-3-carboxamides as potential atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Isoxazoles; Male; Mice; Rats; Rats, Wistar; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles | 1994 |
Cyclic benzamides as mixed dopamine D2/serotonin 5-HT2 receptor antagonists: potential atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Binding, Competitive; Catalepsy; Corpus Striatum; Cyclization; Dopamine D2 Receptor Antagonists; Frontal Lobe; Hippocampus; Indoles; Isoindoles; Male; Mice; Molecular Structure; Motor Activity; Phthalazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Thiazoles | 1994 |
Synthesis and dopamine antagonist activity of 2-thioether derivatives of the ergoline ring system.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Dogs; Dopamine Antagonists; Ergolines; Female; Male; Mice; Rats; Rats, Sprague-Dawley; Rats, Wistar; Structure-Activity Relationship; Sulfides | 1993 |
New pyridobenzodiazepine derivatives as potential antipsychotics: synthesis and neurochemical study.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Binding Sites; Dogs; Rats; Structure-Activity Relationship | 1993 |
Dopamine D4 versus D2 receptor selectivity of dopamine receptor antagonists: possible therapeutic implications.
Topics: Animals; Apomorphine; Butyrophenones; Cell Line; Chlorpromazine; Clozapine; Dopamine Agents; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Raclopride; Radioligand Assay; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Salicylamides; Trifluoperazine | 1993 |
Expression and pharmacological characterization of the human D3 dopamine receptor.
Topics: Animals; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Dopamine; Dopamine Antagonists; GTP-Binding Proteins; Guanine Nucleotides; Humans; Potassium Channels; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Second Messenger Systems; Sulpiride | 1994 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection | 1993 |
1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding.
Topics: Animals; Antipsychotic Agents; Chlorocebus aethiops; Cloning, Molecular; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Pyrroles; Receptors, Dopamine; Recombinant Proteins; Structure-Activity Relationship | 1995 |
3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Brain; Catalepsy; Clozapine; Dopamine; Drug Design; Humans; Molecular Structure; Phosphatidylinositols; Piperazines; Prazosin; Rats; Receptors, Adrenergic; Receptors, Dopamine; Serotonin Antagonists; Thiazoles | 1996 |
Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives.
Topics: Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Brain; Clozapine; Haloperidol; Indoles; Ketanserin; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Phthalimides; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1996 |
3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.
Topics: Animals; Cell Line; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Pyridines; Pyrroles; Receptors, Dopamine D4 | 1996 |
5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.
Topics: Cloning, Molecular; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Isoxazoles; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1996 |
Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.
Topics: Animals; Antipsychotic Agents; Benzamides; CHO Cells; Cricetinae; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Male; Mice; Mice, Inbred ICR; Motor Activity; Rats; Receptors, Dopamine D3; Receptors, Dopamine D4; Structure-Activity Relationship | 1996 |
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Biological Availability; Catalepsy; Chromones; Male; Mice; Molecular Structure; Motor Activity; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Structure-Activity Relationship | 1996 |
Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Binding, Competitive; Cell Line; CHO Cells; Cricetinae; Humans; Male; Molecular Structure; Motor Activity; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Spiperone; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles; Thiazolidines | 1996 |
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.
Topics: Animals; Antipsychotic Agents; Brain; Cells, Cultured; Clozapine; Haloperidol; Humans; Male; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Risperidone | 1996 |
Iloperidone binding to human and rat dopamine and 5-HT receptors.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; CHO Cells; Cricetinae; Humans; Isoxazoles; Kinetics; Piperidines; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Receptors, Dopamine D5; Receptors, Serotonin | 1996 |
2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors.
Topics: Antipsychotic Agents; Clozapine; Dopamine D2 Receptor Antagonists; Humans; Receptors, Dopamine D4 | 1997 |
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
Topics: Cell Line; Humans; Ligands; Piperidines; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1997 |
Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cloning, Molecular; Cricetinae; Dopamine D2 Receptor Antagonists; Humans; Kinetics; Levodopa; Models, Chemical; Piperazines; Pyridines; Pyridones; Pyrroles; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship; Sulfonamides | 1997 |
(Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Humans; Receptors, Dopamine D4; Structure-Activity Relationship | 1997 |
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.
Topics: Animals; Antipsychotic Agents; Clozapine; Male; Rats; Rats, Wistar; Structure-Activity Relationship | 1997 |
[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Imidazoles; Radioligand Assay; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin Antagonists; Transfection; Tritium; Yohimbine | 1998 |
Design of N-acylprolyltyrosine "tripeptoid" analogues of neurotensin as potential atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C57BL; Neurotensin; Rats; Structure-Activity Relationship; Tyrosine | 1998 |
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.
Topics: Animals; Guinea Pigs; Ligands; Piperidines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Opioid; Receptors, Serotonin; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Structure-Activity Relationship | 1998 |
Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors.
Topics: Adrenergic Agents; Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Cerebral Cortex; Conditioning, Psychological; Corpus Striatum; Dopamine Agents; Humans; Male; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Structure-Activity Relationship | 1998 |
Novel benzothiazolin-2-one and benzoxazin-3-one arylpiperazine derivatives with mixed 5HT1A/D2 affinity as potential atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Cattle; Corpus Striatum; Dopamine Agents; Frontal Lobe; Hippocampus; Hyperkinesis; Mice; Oxazines; Piperazines; Rabbits; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sleep; Stereotyped Behavior; Structure-Activity Relationship; Swine; Thiazoles | 1998 |
Creation of a constitutively activated state of the 5-hydroxytryptamine2A receptor by site-directed mutagenesis: inverse agonist activity of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; COS Cells; Mutagenesis, Site-Directed; Phosphatidylinositols; Protein Conformation; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship | 1998 |
S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison w
Topics: Animals; Antipsychotic Agents; CHO Cells; Clozapine; Cricetinae; Dopamine; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Male; Pyrrolidines; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists | 1998 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.
Topics: Animals; Benzamides; Cell Line; Cerebral Cortex; Humans; Insecta; Ligands; Piperazines; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship | 1998 |
Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist.
Topics: Animals; Apomorphine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Design; Haloperidol; Indicators and Reagents; Molecular Structure; Motor Activity; Pyrazines; Pyrimidines; Rats; Receptors, Dopamine D4; Structure-Activity Relationship | 1998 |
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).
Topics: Administration, Oral; Animals; Antipsychotic Agents; Brain; Catalepsy; Cell Line; Chromones; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Isoxazoles; Male; Mice; Motor Activity; Prolactin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Stereotyped Behavior; Structure-Activity Relationship | 1998 |
Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors.
Topics: Antipsychotic Agents; Butyrophenones; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin | 1998 |
New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.
Topics: Animals; Antipsychotic Agents; Benzazepines; Brain; Catalepsy; CHO Cells; Cricetinae; Dopamine Antagonists; Humans; In Vitro Techniques; Male; Mice; Molecular Structure; Piperazines; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Histamine H1; Receptors, Muscarinic; Receptors, Serotonin; Structure-Activity Relationship | 1999 |
Conformationally constrained butyrophenones with mixed dopaminergic (D(2)) and serotoninergic (5-HT(2A), 5-HT(2C)) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical an
Topics: Animals; Antipsychotic Agents; Aorta, Thoracic; Brain; Catalepsy; Cattle; Dopamine Agents; In Vitro Techniques; Isoxazoles; Male; Mice; Models, Molecular; Motor Activity; Muscle Contraction; Muscle, Smooth, Vascular; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Agents; Structure-Activity Relationship; Thiophenes | 1999 |
N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Brain; Catalepsy; Dioxanes; Dopamine Antagonists; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Male; Mice; Motor Activity; Piperidines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Proteins; Serotonin Receptor Agonists; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship; Swine | 1999 |
A structure-affinity relationship study on derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D(4) receptor ligand.
Topics: Animals; Benzamides; Dopamine Agents; Gas Chromatography-Mass Spectrometry; Humans; Ligands; Magnetic Resonance Spectroscopy; Piperazines; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Proteins; Structure-Activity Relationship | 2000 |
Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Haloperidol; Heart; Mice; Oocytes; Pimozide; Potassium Channels; Potassium Channels, Inwardly Rectifying; RNA, Messenger; Thioridazine; Xenopus laevis | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
A rapid computational method for lead evolution: description and application to alpha(1)-adrenergic antagonists.
Topics: Adrenergic alpha-Antagonists; Databases, Factual; Drug Design; Glycine; Heterocyclic Compounds; Ligands; Models, Molecular; Molecular Conformation; Receptors, Adrenergic, alpha-1 | 2000 |
trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Cytochrome P-450 Enzyme System; Dopamine Antagonists; Humans; In Vitro Techniques; Male; Microsomes, Liver; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Dopamine D4; Stereoisomerism; Structure-Activity Relationship | 2000 |
Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Binding, Competitive; Butyrophenones; Catalepsy; Cattle; Corpus Striatum; Frontal Lobe; Humans; In Vitro Techniques; Isoxazoles; Male; Mice; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Retina | 2000 |
Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Piperidines; Protein Binding; Psychomotor Agitation; Psychotic Disorders; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists | 2001 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Benzoxazoles; Dopamine Antagonists; Drug Design; Drug Evaluation, Preclinical; Mice; Piperazines; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Spiperone; Structure-Activity Relationship | 2001 |
New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.
Topics: Animals; Aorta; Butyrophenones; CHO Cells; Cricetinae; Cycloparaffins; Frontal Lobe; Heterocyclic Compounds; Humans; In Vitro Techniques; Ligands; Male; Models, Molecular; Muscle, Smooth, Vascular; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Stomach | 2002 |
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Behavior, Animal; Brain; Catalepsy; Crystallography, X-Ray; Dopamine; Dopamine Antagonists; Homovanillic Acid; In Vitro Techniques; Male; Mice; Microdialysis; Models, Molecular; Molecular Conformation; Molecular Structure; Prolactin; Pyrroles; Radioligand Assay; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Dopamine D2; Stereoisomerism; Structure-Activity Relationship; Thiazepines | 2002 |
In vitro P-glycoprotein affinity for atypical and conventional antipsychotics.
Topics: Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepines; Binding, Competitive; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Humans; Kinetics; Olanzapine; Pirenzepine; Quetiapine Fumarate; Recombinant Proteins; Risperidone | 2002 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Synthesis and pharmacological evaluation of 1-[(1,2-diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D(2), serotonin, and GABA(A) receptors.
Topics: Animals; Cerebral Cortex; Chloride Channels; Clozapine; Dopamine; Dopamine Antagonists; Drug Design; GABA Antagonists; Humans; Imidazoles; In Vitro Techniques; Oocytes; Piperazines; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, GABA-A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Xenopus laevis | 2002 |
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.
Topics: Amphetamine; Animals; Antipsychotic Agents; Binding, Competitive; Catalepsy; Central Nervous System Stimulants; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; Half-Life; Haloperidol; Humans; In Vitro Techniques; Indicators and Reagents; Indoles; Motor Activity; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 2002 |
New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
Topics: Amines; Animals; Antidepressive Agents; Benzodiazepines; Catalepsy; Cell Line; Dopamine Agents; Female; Humans; Mice; Molecular Conformation; Piperazines; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Serotonin; Serotonin Agents; Structure-Activity Relationship | 2002 |
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.
Topics: Animals; Benzamides; Benzofurans; Cell Line; Cerebral Cortex; Hippocampus; Humans; In Vitro Techniques; Ligands; Piperazines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship | 2002 |
Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Azoles; Brain; Cell Line; Cricetinae; Humans; Imidazoles; In Vitro Techniques; Indoles; Pyridines; Pyrimidines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship; Triazoles | 2003 |
H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Discriminant Analysis; Drug Evaluation, Preclinical; Forecasting; Humans; Protein Binding; Receptors, Histamine H1; Statistics, Nonparametric; Weight Gain | 2003 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.
Topics: Algorithms; Binding Sites; Computational Biology; Crystallography, X-Ray; Databases, Protein; Humans; Kinetics; Ligands; Lipid Bilayers; Models, Molecular; Molecular Conformation; Mutation; Receptors, Dopamine D2; Receptors, Dopamine D3; Reproducibility of Results; Solvents; Structure-Activity Relationship; Tetrahydronaphthalenes; Water | 2003 |
The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+.
Topics: Acetyl-CoA Carboxylase; Animals; Antipsychotic Agents; Apomorphine; Basal Ganglia Diseases; Carrier Proteins; Catalepsy; Dopamine Agonists; Fatty Acid Synthase, Type II; Haloperidol; Humans; Male; Mice; Psychomotor Performance; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Stereotyped Behavior | 2003 |
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzothiepins; Catalepsy; Cognition Disorders; Dopamine Antagonists; Humans; Male; Mice; Models, Molecular; Motor Activity; Pituitary Gland, Anterior; Prolactin; Pyrroles; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin, 5-HT2; Serotonin Antagonists; Structure-Activity Relationship; Thiazepines | 2004 |
Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+-like species.
Topics: Animals; Azepines; Catalepsy; Clozapine; Drug Design; Haloperidol; Humans; In Vitro Techniques; Male; Mice; Piperidines; Quaternary Ammonium Compounds; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Dopamine D4; Stereoisomerism; Stereotyped Behavior; Structure-Activity Relationship | 2004 |
Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.
Topics: Antipsychotic Agents; Binding Sites; Haloperidol; Lipase; Pseudomonas fluorescens; Receptors, Dopamine D2; Receptors, Serotonin; Stereoisomerism; Tetralones | 2004 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Pharmacological characterization of AC-90179 [2-(4-methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide hydrochloride]: a selective serotonin 2A receptor inverse agonist.
Topics: 3T3 Cells; Animals; Benzamides; Biological Availability; Brain; Caco-2 Cells; Catalepsy; Cell Membrane Permeability; Female; Humans; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Motor Activity; Nose; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists | 2004 |
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.
Topics: Acetamides; Cell Line; Humans; In Vitro Techniques; Ligands; Piperazines; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Structure-Activity Relationship; Tritium | 2004 |
A two-state homology model of the hERG K+ channel: application to ligand binding.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation | 2005 |
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzazepines; Binding Sites; Catalepsy; Catalysis; Cell Line; Crystallography, X-Ray; Dopamine D2 Receptor Antagonists; Drug Design; In Vitro Techniques; Mice; Models, Molecular; Molecular Conformation; Palladium; Pyrroles; Radioligand Assay; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Serotonin 5-HT2 Receptor Antagonists; Structure-Activity Relationship | 2005 |
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; In Vitro Techniques; Mice; Psychotropic Drugs; Radioligand Assay; Rats; Stereoisomerism; Structure-Activity Relationship | 2005 |
Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics.
Topics: Antipsychotic Agents; Binding Sites; Haloperidol; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT2; Tetralones | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism.
Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol.
Topics: Animals; Butanones; Clozapine; Haloperidol; Humans; Isomerism; Mice; Molecular Structure; Pyrrolidines; Rats | 2006 |
2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.
Topics: Animals; Cattle; CHO Cells; Cricetinae; Cricetulus; Erectile Dysfunction; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Ligands; Male; Mitosis; Penile Erection; Piperazines; Pyridines; Pyrroles; Radioligand Assay; Rats; Receptors, Dopamine D4; Structure-Activity Relationship | 2006 |
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
Topics: Animals; Benzamides; Binding Sites; Cell Line; Crystallography, X-Ray; Disease Models, Animal; Drug Evaluation, Preclinical; Erectile Dysfunction; Ferrets; Humans; Male; Models, Molecular; Molecular Structure; Oximes; Piperazines; Rats; Rats, Wistar; Receptors, Dopamine D4; Stereoisomerism; Structure-Activity Relationship | 2006 |
Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.
Topics: Action Potentials; Administration, Oral; Animals; Benzamides; Biological Availability; Cell Line; Cyclic N-Oxides; Dogs; Erectile Dysfunction; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Haplorhini; Humans; In Vitro Techniques; Male; Patch-Clamp Techniques; Purkinje Fibers; Rats; Receptors, Dopamine D4; Structure-Activity Relationship | 2006 |
Design and synthesis of novel derivatives of the muscarinic agonist tetra(ethylene glycol)(3-methoxy-1,2,5-thiadiazol-4-yl) [3-(1-methyl-1,2,5,6-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl] ether (CDD-0304): effects of structural modifications on the bind
Topics: Animals; Antipsychotic Agents; Cell Line; Cyclic AMP; Drug Design; Humans; Hydrolysis; Ligands; Mice; Models, Molecular; Muscarinic Agonists; Mutagenesis, Site-Directed; Mutation; Phosphatidylinositols; Piperidines; Radioligand Assay; Receptors, Muscarinic; Recombinant Fusion Proteins; Structure-Activity Relationship; Thiadiazoles | 2006 |
From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase.
Topics: Adenylate Kinase; Animals; Antipsychotic Agents; Enzyme Activation; Hypothalamus; Immunohistochemistry; Mice; Phosphorylation; Receptors, Histamine H1; Weight Gain | 2007 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.
Topics: Antipsychotic Agents; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen Bonding; Isoxazoles; Kinetics; Models, Chemical; Molecular Conformation; Protein Binding; Pyrazoles; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D2; Software | 2007 |
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats | 2007 |
Two new phenylpiperazines with atypical antipsychotic potential.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Cricetulus; Piperazines; Rats | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzoxazines; Biogenic Monoamines; Humans; Hyperprolactinemia; Indoles; Metabolic Diseases; Phthalimides; Piperazines; Principal Component Analysis; Pyridines; Radioligand Assay; Receptors, Biogenic Amine; Weight Gain | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Asenapine: a novel psychopharmacologic agent with a unique human receptor signature.
Topics: Benzodiazepines; Bipolar Disorder; Clinical Trials as Topic; Cloning, Molecular; Clozapine; Dibenzocycloheptenes; Heterocyclic Compounds, 4 or More Rings; Histamine Release; Humans; Inhibitory Concentration 50; Molecular Structure; Olanzapine; Psychotropic Drugs; Radioligand Assay; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Serotonin; Schizophrenia; Substrate Specificity | 2009 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.
Topics: Animals; Antipsychotic Agents; Apomorphine; Azepines; Butyrophenones; Clozapine; Haloperidol; Lethal Dose 50; Male; Mice; Molecular Structure; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Structure-Activity Relationship | 2008 |
Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.
Topics: Antipsychotic Agents; Benzofurans; Binding, Competitive; Cloning, Molecular; Computer Simulation; Crystallography, X-Ray; Humans; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Structure; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D2; Sequence Alignment; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Binding Sites; Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Mice; Models, Molecular; Molecular Structure; Protein Binding; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D3; Structure-Activity Relationship | 2009 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
Topics: Binding Sites; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Models, Molecular; Potassium Channel Blockers; Protein Binding; Protein Conformation | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.
Topics: Animals; Antipsychotic Agents; Blood-Brain Barrier; CHO Cells; Cricetinae; Cricetulus; Humans; Quinazolinones; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Schizophrenia | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Cell Line; Humans; Ligands; Male; Mice; Piperazines; Pyrazoles; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Schizophrenia | 2010 |
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.
Topics: Animals; Antipsychotic Agents; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Mice; Models, Molecular; Piperazines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D3; Structure-Activity Relationship | 2010 |
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Molecular properties affecting fast dissociation from the D2 receptor.
Topics: Antipsychotic Agents; Dopamine D2 Receptor Antagonists; Drug Administration Schedule; Drug Design; Humans; Molecular Structure; Receptors, Dopamine D2; Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Synthesis, computational studies and preliminary pharmacological evaluation of 2-[4-(aryl substituted) piperazin-1-yl] N, N-diphenylacetamides as potential antipsychotics.
Topics: Acetamides; Antipsychotic Agents; Magnetic Resonance Spectroscopy; Piperazines; Spectrometry, Mass, Electrospray Ionization | 2011 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics | 2012 |
Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.
Topics: Antipsychotic Agents; Butyrophenones; Drug Design; Haloperidol; Humans; Receptors, Dopamine; Receptors, Serotonin | 2012 |
Quinoline- and isoquinoline-sulfonamide derivatives of LCAP as potent CNS multi-receptor-5-HT1A/5-HT2A/5-HT7 and D2/D3/D4-agents: the synthesis and pharmacological evaluation.
Topics: Animals; Antipsychotic Agents; Central Nervous System; Isoquinolines; Mice; Piperazines; Quinolines; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Structure-Activity Relationship; Sulfonamides | 2012 |
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2012 |
Current landscape of phosphodiesterase 10A (PDE10A) inhibition.
Topics: Animals; Cyclic AMP; Cyclic GMP; Humans; Hydrolysis; Mice; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Biological Availability; Coumarins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; In Vitro Techniques; Isoxazoles; Lethal Dose 50; Mice; Motor Activity; Prolactin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Weight Gain | 2013 |
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Drug Design; Locomotion; Male; Mice; Piperazines; Receptor, Serotonin, 5-HT2A; Schizophrenia | 2013 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols as dual dopamine/serotonin ligands.
Topics: Antipsychotic Agents; Dopamine; Dopamine D2 Receptor Antagonists; Humans; Ligands; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Tetralones | 2014 |
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.
Topics: Benzodiazepinones; Isomerism; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface | 2014 |
Synthesis and evaluation of new coumarin derivatives as potential atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Coumarins; Magnetic Resonance Spectroscopy; Mice; Spectrometry, Mass, Electrospray Ionization | 2014 |
Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Biological Availability; Drug Discovery; Electroshock; Indicators and Reagents; Male; Mental Disorders; Nervous System Diseases; Quinoxalines; Quipazine; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Recombinant Proteins; Schizophrenia; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship | 2014 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.
Topics: Amides; Animals; Antipsychotic Agents; Behavior, Animal; Dizocilpine Maleate; Dopamine Antagonists; Drug Evaluation, Preclinical; Female; Kinetics; Ligands; Male; Mice; Prefrontal Cortex; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D3; Schizophrenia; Serotonin Receptor Agonists; Structure-Activity Relationship | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.
Topics: Animals; Antipsychotic Agents; Ether-A-Go-Go Potassium Channels; Humans; Mice; Oxazoles; Patch-Clamp Techniques; Piperazines; Piperidines; Potassium Channel Blockers; Rats; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Structure-Activity Relationship; Swine | 2015 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Highly predictive and interpretable models for PAMPA permeability.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine | 2017 |
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Topics: Animals; Antipsychotic Agents; Body Weight; Chemistry Techniques, Synthetic; Drug Design; Ether-A-Go-Go Potassium Channels; Heterocyclic Compounds; Memory; Mice; Piperazine; Rats; Schizophrenia; Structure-Activity Relationship; Tissue Distribution | 2018 |
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
Topics: Animals; Chemistry Techniques, Synthetic; Drug Design; Ligands; Mice; Pyrimidines; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Tryptamines | 2019 |
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility | 2019 |
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
Topics: Animals; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Ligands; Male; Mice; Models, Molecular; Molecular Structure; Pyrimidines; Rats; Receptor, Serotonin, 5-HT1A; RNA-Binding Proteins; Structure-Activity Relationship; Tryptamines | 2019 |
Identification of C10 nitrogen-containing aporphines with dopamine D
Topics: Aporphines; Dopamine Agonists; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Receptors, Dopamine D1; Receptors, Dopamine D5; Structure-Activity Relationship | 2020 |
Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy.
Topics: Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Structure; Piperidines; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Serotonin Antagonists; Structure-Activity Relationship | 2020 |
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT
Topics: Aporphines; Cell Line; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 2020 |
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States | 2020 |
[An experimental study of the spectrum of individual psychotropic activity of clozapine (Leponex)].
Topics: Animals; Antipsychotic Agents; Cats; Clozapine; Diazepam; Dibenzazepines; Disease Models, Animal; Haloperidol; Humans; Mental Disorders; Neurotic Disorders; Psychotic Disorders; Social Behavior; Tranquilizing Agents | 1975 |
Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity.
Topics: Animals; Clozapine; Dopamine; Haloperidol; Hydrogen-Ion Concentration; Limbic System; Male; Motor Activity; Osmolar Concentration; Rats; Stimulation, Chemical; Theophylline; Time Factors | 1976 |
Correlation between neuroleptic-induced suppression of stereotyped behaviour and HVA concentrations in rat brain.
Topics: Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Behavior; Brain Chemistry; Clozapine; Depression, Chemical; Haloperidol; Homovanillic Acid; Humans; Male; Phenothiazines; Phenylacetates; Pimozide; Rats; Stereotyped Behavior; Tranquilizing Agents | 1976 |
Differential effect of neuroleptic drugs on dopamine turnover in the extrapyramidal and limbic system.
Topics: Animals; Caudate Nucleus; Chlorpromazine; Clozapine; Dopamine; Extrapyramidal Tracts; Haloperidol; Homovanillic Acid; Limbic System; Male; Olfactory Bulb; Rats; Sulpiride; Thioridazine; Tranquilizing Agents | 1976 |
[Acute and chronic effects of carpipramine, clozapine, haloperidol and sulpiride on the metabolism of biogenic amines in the rat brain (author's transl)].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Biogenic Amines; Brain; Brain Chemistry; Cerebral Cortex; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Limbic System; Male; Methoxyhydroxyphenylglycol; Rats; Sulpiride | 1976 |
A pharmacologic model of Huntington's chorea.
Topics: Animals; Carbachol; Catheterization; Clozapine; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Haloperidol; Huntington Disease; Hydrazines; Levodopa; Male; Phentolamine; Rats; Trifluoperazine; Tyramine | 1976 |
The effects of antipsychotics on the turnover rate of GABA and acetylcholine in rat brain nuclei.
Topics: Acetylcholine; Aminobutyrates; Animals; Antipsychotic Agents; Brain; Caudate Nucleus; Chlorpromazine; Clozapine; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Olfactory Bulb; Rats; Substantia Nigra | 1976 |
Anticholinergic properties of antipsychotic drugs and their relation to extrapyramidal side-effects.
Topics: Animals; Antipsychotic Agents; Atropine; Basal Ganglia Diseases; Clozapine; Corpus Striatum; Drug Interactions; Dyskinesia, Drug-Induced; Female; Haloperidol; Homovanillic Acid; Male; Parasympathetic Nervous System; Physostigmine; Rats; Receptors, Dopamine; Receptors, Muscarinic | 1976 |
Potentiation by alpha-methyltyrosine of the suppression of food-reinforced lever-pressing behaviour induced by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Catecholamines; Chlorpromazine; Clozapine; Conditioning, Operant; Drug Synergism; Feeding Behavior; Haloperidol; Male; Methyltyrosines; Phenoxybenzamine; Pimozide; Rats; Receptors, Adrenergic; Thioridazine | 1977 |
[Psychopharmacological influence on the prey catching behavior of ferrets (Putorius furo L.) (author's transl)].
Topics: Animals; Antipsychotic Agents; Appetitive Behavior; Carnivora; Chlorpromazine; Clozapine; Conditioning, Classical; Ferrets; Haloperidol; Male; Orientation; Predatory Behavior | 1977 |
Paradoxical response to dopamine agonists in tardive dyskinesia.
Topics: Adrenergic alpha-Agonists; Adult; Amantadine; Apomorphine; Benztropine; Clozapine; Deanol; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Levodopa; Physostigmine; Receptors, Dopamine; Reserpine; Stimulation, Chemical; Thioridazine | 1977 |
The turnover rate of gamma-aminobutyric acid in the nuclei of telencephalon: implications in the pharmacology of antipsychotics and of a minor tranquilizer.
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Caudate Nucleus; Clozapine; Corpus Striatum; Diazepam; gamma-Aminobutyric Acid; Globus Pallidus; Glutamates; Haloperidol; Male; Parasympathomimetics; Rats; Substantia Nigra; Telencephalon | 1977 |
Acetylcholine turnover rate in n. accumbens, n. caudatus, globus pallidus, and substantia nigra: action of cataleptogenic and non-cataleptogenic antipsychotics.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Catalepsy; Caudate Nucleus; Chlorpromazine; Clozapine; Globus Pallidus; Haloperidol; Humans; Male; Olfactory Bulb; Rats; Substantia Nigra | 1977 |
Behavioral patterns related to dopamine neurotransmission: effect of acute and chronic antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Brain; Clozapine; Dopamine; Electric Stimulation; Haloperidol; Motor Activity; Rats; Synaptic Transmission; Time Factors | 1977 |
Chronic neuroleptic therapy: tolerance and GABA systems.
Topics: Adenylyl Cyclases; Aminobutyrates; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Catalepsy; Cerebellum; Clozapine; Corpus Striatum; Dopamine; Drug Tolerance; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Haloperidol; Humans; Male; Norepinephrine; Rats; Substantia Nigra; Time Factors | 1977 |
Nonstriatal dopaminergic neurons: Section X. Morphine, amphetamine, and noncataleptogenic neuroleptics: Introduction: morphine, amphetamine, and noncataleptogenic neuroleptics.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Brain; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; gamma-Aminobutyric Acid; Glutamates; Haloperidol; Morphine; Neurotransmitter Agents; Rats; Receptors, Dopamine; Receptors, Opioid; Sulpiride | 1977 |
Biochemical methods to assess the action of clozapine and haloperidol on presynaptic dopamine neurons.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Cyclic AMP; Dibenzazepines; Dopamine; Haloperidol; Neurons; Olfactory Bulb; Rats; Synapses; Tyrosine 3-Monooxygenase | 1977 |
Brain homovanillic acid: regional changes following chronic antipsychotic drug administration.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Chlorpromazine; Clozapine; Drug Tolerance; Fluphenazine; Haloperidol; Homovanillic Acid; Male; Phenylacetates; Rabbits; Thioridazine; Time Factors | 1977 |
Participation of an endogenous Ca++-blinding protein activator in the development of drug-induced supersensitivity of striatal dopamine receptors.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Apomorphine; Calcium; Carrier Proteins; Clozapine; Corpus Striatum; Dibenzocycloheptenes; Dopamine; Haloperidol; Humans; Male; Rats; Receptors, Dopamine; Stereotyped Behavior | 1977 |
[Effects of minor tranquilizers and neuroleptics on open-field behavior in rats (author's transl)].
Topics: Animals; Anti-Anxiety Agents; Butyrophenones; Chlorpromazine; Clozapine; Defecation; Haloperidol; Male; Methamphetamine; Motor Activity; Rats; Thioridazine; Tranquilizing Agents; Trifluperidol | 1977 |
Evaluation of naloxone in laboratory tests predictive of clinical antipsychotic activity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Clozapine; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Mice; Naloxone; Rats; Schizophrenia; Species Specificity; Stereotyped Behavior | 1977 |
Substance P content of substantia nigra after chronic treatment with antischizophrenic drugs.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Pimozide; Rats; Substance P; Substantia Nigra; Time Factors | 1978 |
Tolerance to tyrosine hydroxylase activation in n. accumbens and c. striatum after repeated injections of "classical" and "atypical" antischizophrenic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Corpus Striatum; Drug Tolerance; Enzyme Activation; Haloperidol; Nucleus Accumbens; Rats; Septal Nuclei; Tyrosine 3-Monooxygenase | 1978 |
Blockade of lergotrile or apomorphine induced turning behavior by haloperidol and clozapine.
Topics: Animals; Apomorphine; Behavior; Clozapine; Corpus Striatum; Dibenzazepines; Dominance, Cerebral; Dose-Response Relationship, Drug; Ergolines; Haloperidol; Humans; Hydroxydopamines; Male; Medial Forebrain Bundle; Premedication; Rats; Receptors, Dopamine; Stereotyped Behavior; Substantia Nigra | 1978 |
[Pharmacopsychiatry and iatrogenic parkinsonism].
Topics: Antiparkinson Agents; Antipsychotic Agents; Clozapine; Haloperidol; Humans; Parkinson Disease; Parkinson Disease, Secondary; Receptors, Cholinergic; Sleep | 1978 |
3-Methoxytyramine and different neuroleptics: dissociation from HVA and DOPAC.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Haloperidol; Homovanillic Acid; Kainic Acid; Male; Phenylacetates; Rats; Tyramine | 1978 |
The effect of neuroleptic drugs on drinking induced by central administration of angiotensin or carbachol.
Topics: Angiotensin II; Animals; Antipsychotic Agents; Carbachol; Chlorpromazine; Clozapine; Dopamine; Drinking Behavior; Flupenthixol; Fluphenazine; Haloperidol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pimozide; Rats; Sulpiride | 1979 |
Neuroleptics-induced changes of tyrosine hydroxylase activity in rat striatum in vitro and in vivo.
Topics: Animals; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Homovanillic Acid; Kinetics; Male; Rats; Tyrosine 3-Monooxygenase | 1979 |
[Norepinephrine turnover under neuroleptic treatment of schizophrenic syndromes (author's transl)].
Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Haloperidol; Humans; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Schizophrenia | 1978 |
Tricyclic antidepressants and histamine H1 receptors.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Clozapine; Cyproheptadine; Desipramine; Doxepin; Haloperidol; Histamine H1 Antagonists; Hydroxyzine; Imipramine; Mice; Neoplasms, Experimental; Neuroblastoma; Nortriptyline; Protriptyline; Receptors, Histamine; Receptors, Histamine H1; Receptors, Muscarinic | 1979 |
Inhibition of apomorphine-induced climbing in mice by cholinergic drugs and neuroleptics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Female; Haloperidol; Injections, Intramuscular; Mice; Oxotremorine; Parasympathomimetics; Physostigmine | 1979 |
The effect of neuroleptics on brain tyrosine hydroxylase.
Topics: Amitriptyline; Animals; Antidepressive Agents; Antipsychotic Agents; Brain; Clozapine; Fluphenazine; Haloperidol; Hypothalamus; Male; Promethazine; Rats; Tyrosine 3-Monooxygenase | 1978 |
A comparison between a new antipsychotic screening technique (shelf jump avoidance) and a classical discriminative avoidance paradigm.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Chlorpromazine; Clozapine; Conditioning, Classical; Discrimination Learning; Dose-Response Relationship, Drug; Haloperidol; Male; Rats; Thioridazine | 1979 |
Crop-sac response after systemic and intraventricular administration of neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Clozapine; Columbidae; Crop, Avian; Female; Haloperidol; Injections, Intraventricular; Reserpine; Sulpiride | 1979 |
d-Amphetamine and punished responding: the role of catecholamines and anorexia.
Topics: Animals; Anorexia; Antipsychotic Agents; Catecholamines; Clozapine; Conditioning, Operant; Dextroamphetamine; Dopamine Antagonists; Feeding and Eating Disorders; Food Deprivation; Haloperidol; Humans; Male; Methyltyrosines; Phentolamine; Punishment; Rats | 1979 |
Inhibition of 4,alpha-dimethyl-m-tyramine (H 77/77)-induced hypermotility in rats by single and repeated administration of chloropromazine, haloperidol, clozapine and thioridazine.
Topics: Adrenergic Agents; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Haloperidol; Motor Activity; Rats; Thioridazine; Tyramine | 1975 |
Neuropharmacological and behavioral evaluation of prostaglandin E2 and 11-thiol-11-desoxy prostaglandin E2 in the mouse and rat.
Topics: Animals; Avoidance Learning; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Fluphenazine; Haloperidol; Humans; Male; Mice; Motor Activity; Physostigmine; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Stereotyped Behavior; Thioridazine | 1978 |
Evidence that the different properties of haloperidol and clozapine are not explained by differences in anticholinergic potency.
Topics: Animals; Apomorphine; Behavior; Behavior, Animal; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Haloperidol; Humans; Male; Motor Activity; Rats; Scopolamine; Stereotyped Behavior | 1979 |
Enhancement of self-stimulation behavior in rats and monkeys after chronic neuroleptic treatment: evidence for mesolimbic supersensitivity.
Topics: Animals; Clozapine; Dibenzazepines; Female; Haloperidol; Haplorhini; Macaca mulatta; Male; Olfactory Bulb; Rats; Self Stimulation; Stereotaxic Techniques; Tegmentum Mesencephali | 1979 |
Influence of drugs on striatal and limbic homovanillic acid concentration in the rat brain.
Topics: Aminooxyacetic Acid; Animals; Atropine; Brain; Brain Chemistry; Clozapine; Corpus Striatum; Fenclonine; Haloperidol; Homovanillic Acid; Limbic System; Male; Morphine; Oxotremorine; Phenylacetates; Physostigmine; Pimozide; Probenecid; Rats; Substantia Nigra; Trihexyphenidyl | 1975 |
Evidence for a noradrenergic mechanism in the grooming produced by (+)-amphetamine and 4, alpha-dimethyl-m-tyramine (H 77/77) in rats.
Topics: Amphetamine; Animals; Butyrophenones; Clozapine; Diazepam; Diphenhydramine; Grooming; Haloperidol; Male; Norepinephrine; Phenothiazines; Rats; Tyramine | 1977 |
Effect of antipsychotic drugs on homovanillic acid levels in striatum and olfactory tubercle of the rat.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Male; Olfactory Bulb; Phenylacetates; Rats; Stimulation, Chemical; Thioridazine | 1975 |
Drug-induced changes of dopamine turnover in striatum and limbic system of the rat.
Topics: Animals; Brain Chemistry; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Limbic System; Male; Oxotremorine; Rats; Species Specificity; Stimulation, Chemical; Tranquilizing Agents; Trihexyphenidyl | 1975 |
Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Catecholamines; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzothiepins; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Hypothalamus; Kinetics; Male; Norepinephrine; Pimozide; Promethazine; Rats; Thioridazine; Tyrosine 3-Monooxygenase | 1975 |
On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Homovanillic Acid; Humans; Limbic System; Male; Phenylacetates; Pimozide; Rats; Receptors, Drug; Rotation; Stereotyped Behavior; Substantia Nigra; Thioridazine | 1975 |
3H-Spiroperidol binding to dopamine receptors in rat striatal membranes: influence of loxapine and its hydroxylated metabolites.
Topics: Animals; Butyrophenones; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzoxazepines; Haloperidol; Hydroxylation; In Vitro Techniques; Loxapine; Membranes; Rats; Receptors, Dopamine; Spiperone | 1979 |
Effects of clozapine, chlorpromazine and haloperidol on schedule-controlled behavior.
Topics: Animals; Chlorpromazine; Clozapine; Columbidae; Conditioning, Operant; Dibenzazepines; Haloperidol; Male; Mice; Mice, Inbred C57BL; Reinforcement Schedule | 1979 |
Two dopamine receptors: supportive evidence with the rat rotational model.
Topics: Animals; Apomorphine; Behavior; Clozapine; Corpus Striatum; Dopamine; Ergolines; Haloperidol; Humans; Limbic System; Male; Rats; Receptors, Dopamine; Stereotyped Behavior; Time Factors | 1977 |
Neuroleptics attentuate stereotyped behavior induced by beta-phenylethylamine in rats.
Topics: Animals; Behavior; Chlorpromazine; Clozapine; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Evaluation; Haloperidol; Humans; Male; Phenethylamines; Pimozide; Rats; Receptors, Dopamine; Stereotyped Behavior; Tranquilizing Agents | 1978 |
The effects of haloperidol and clozapine on circling induced by electrical stimulation of the substantia nigra and the ventromedial tegmentum.
Topics: Animals; Behavior; Clozapine; Dibenzazepines; Electric Stimulation; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Stereotyped Behavior; Substantia Nigra; Tegmentum Mesencephali; Time Factors | 1978 |
Discriminative stimulus properties of clozapine and chlorpromazine.
Topics: Animals; Chlorpromazine; Clozapine; Dibenzazepines; Discrimination, Psychological; Electroshock; Haloperidol; Male; Rats | 1978 |
[Effect of neuroleptics on acetylcholine metabolism in the basal ganglia of the brain].
Topics: Acetylcholine; Acetylcholinesterase; Animals; Basal Ganglia; Chlorpromazine; Clozapine; Haloperidol; Male; Pimozide; Rats; Tranquilizing Agents | 1978 |
Self-inhibitory dopamine-receptors and central effects of apomorphine.
Topics: Animals; Apomorphine; Benperidol; Brain; Clozapine; Droperidol; Exploratory Behavior; Haloperidol; Humans; Mice; Motor Activity; Pimozide; Rats; Receptors, Dopamine; Sleep | 1978 |
A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Fluphenazine; Haloperidol; Limbic System; Male; Metoclopramide; Pimozide; Rats; Stereotaxic Techniques; Sulpiride; Thioridazine; Tranquilizing Agents | 1976 |
Modulation of reward and aversion processes in the rat diencephalon by neuroleptics: differential effects of clozapine and haloperidol.
Topics: Animals; Avoidance Learning; Clozapine; Dibenzazepines; Dopamine; Haloperidol; Hypothalamus; Male; Norepinephrine; Rats; Reward; Self Stimulation | 1976 |
Catecholamine-sensitive adenylate cyclase in frontal cortex of primate brain.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Calcium; Catecholamines; Cerebral Cortex; Clozapine; Dopamine; Drug Combinations; Fluphenazine; Frontal Lobe; Guanosine Triphosphate; Haloperidol; Haplorhini; Isoproterenol; Macaca mulatta; Norepinephrine; Phentolamine; Receptors, Adrenergic; Receptors, Dopamine; Sodium Fluoride; Time Factors | 1976 |
Dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Humans; Macaca mulatta; Male; Methadone; Methamphetamine; Naloxone; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Stereotyped Behavior | 1976 |
Susceptibility to amphetamine-elicited dyskinesias following chronic methadone treatment in monkeys.
Topics: Animals; Chlorpromazine; Clozapine; Diazepam; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Macaca mulatta; Male; Methadone; Methamphetamine; Phenobarbital; Phentolamine; Physostigmine; Spiperone; Time Factors | 1976 |
A comparison of the effects of haloperidol on dopamine turnover in the striatum, olfactory tubercule and median eminence.
Topics: Animals; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Hypophysectomy; Hypothalamo-Hypophyseal System; Male; Median Eminence; Methyltyrosines; Olfactory Bulb; Rats; Thioridazine; Time Factors | 1977 |
Dopaminergic supersensitivity in striatum and olfactory tubercle following chronic administration of haloperidol or clozapine.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Male; Methyltyrosines; Mice; Mice, Inbred ICR; Motor Activity; Olfactory Bulb; Receptors, Dopamine; Time Factors | 1977 |
Haloperidol and clazapine: specificity of action on GABA in the nigrostriatal system.
Topics: Aminobutyrates; Animals; Clozapine; Corpus Striatum; Dibenzazepines; gamma-Aminobutyric Acid; Haloperidol; Male; Rats; Substantia Nigra | 1977 |
Apparent lack of a dopaminergic-cholinergic link in the rat nucleus accumbens septi-tuberculum olfactorium.
Topics: Acetylcholine; Animals; Apomorphine; Bromocriptine; Chlorpromazine; Clozapine; Dextroamphetamine; Haloperidol; Nucleus Accumbens; Olfactory Bulb; Pimozide; Piribedil; Rats; Receptors, Cholinergic; Receptors, Dopamine; Septal Nuclei | 1977 |
Effect of chronic neuroleptic or L-DOPA administration on GABA levels in the rat substantia nigra.
Topics: Aminobutyrates; Animals; Clozapine; Dibenzazepines; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Haloperidol; Levodopa; Male; Rats; Substantia Nigra | 1977 |
Acidic dopamine metabolites in cortical areas of the rat brain: localization and effects of drug.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Apomorphine; Cerebral Cortex; Clozapine; Corpus Striatum; Haloperidol; Homovanillic Acid; Male; Morphine; Olfactory Bulb; Oxotremorine; Phenylacetates; Probenecid; Rats; Sulpiride; Thioridazine | 1976 |
Specificity of the dopamine sensitive adenylate cyclase for antipsychotic antagonists.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Activation; Haloperidol; Male; Metoclopramide; Rats; Sulpiride | 1976 |
Behavioral evidence for supersensitivity after chronic administration of haloperidol, clozapine, and thioridazine.
Topics: Animals; Apomorphine; Behavior; Clozapine; Dibenzazepines; Dopamine; Haloperidol; Humans; Motor Activity; Rats; Receptors, Drug; Stereotyped Behavior; Thioridazine; Time Factors | 1976 |
[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Pharmacological findings (author's transl)].
Topics: Animals; Apomorphine; Atropine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Synergism; Haloperidol; Humans; Movement Disorders; Rats; Receptors, Drug; Stereotyped Behavior | 1976 |
[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Neurochemical findings (author's transl)].
Topics: Animals; Atropine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Synergism; Drug Tolerance; Haloperidol; Homovanillic Acid; Rats; Receptors, Drug | 1976 |
On the relevance of preferential increases of mesolimbic versus striatal dopamine turnover for the prediction of antipsychotic activity of psychotropic drugs.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anthracenes; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Haloperidol; Homovanillic Acid; Humans; Limbic System; Male; Methyltyrosines; Psychotic Disorders; Psychotropic Drugs; Rats; Sulpiride; Thioridazine | 1976 |
Effect of psychotropic drugs on caudate spindle in cats.
Topics: Animals; Arousal; Biperiden; Cats; Caudate Nucleus; Chlorpromazine; Clozapine; Diazepam; Electric Stimulation; Electroencephalography; Female; Haloperidol; Imipramine; Male; Pentobarbital; Psychotropic Drugs; Time Factors | 1976 |
Correlation between catalepsy and dopamine decrease in the rat striatum induced by neuroleptics.
Topics: Animals; Butyrophenones; Catalepsy; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Rats; Sulpiride; Thioridazine; Time Factors; Tranquilizing Agents; Trifluperidol | 1976 |
Effect of neuroleptic drugs on mouse jumping induced by L-DOPA in amphetamine treated mice.
Topics: Amphetamine; Animals; Behavior; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Humans; Levodopa; Male; Mice; Pimozide; Promethazine; Psychotropic Drugs; Stereotyped Behavior; Thioridazine; Tranquilizing Agents | 1976 |
Clozapine increases rat serum prolactin levels.
Topics: Animals; Brain; Chlorpromazine; Clozapine; Dibenzazepines; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Male; Prolactin; Rats; Receptors, Drug; Stimulation, Chemical | 1975 |
Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias. Effects of clozapine, haloperidol, loxapine and chlorpromazine.
Topics: Animals; Apomorphine; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; Dibenzoxazepines; Disease Models, Animal; Dopamine; Drug Tolerance; Female; Haloperidol; Homovanillic Acid; Humans; Loxapine; Male; Movement Disorders; Rats; Receptors, Drug; Stereotyped Behavior; Substance Withdrawal Syndrome | 1975 |
Detection of the nueroleptic properties of clozapine, sulpiride and thioridazine.
Topics: Animals; Apomorphine; Behavior, Animal; Catalepsy; Clozapine; Dextroamphetamine; Dibenzazepines; Dose-Response Relationship, Drug; Drug Synergism; Fluphenazine; Haloperidol; Humans; Isoquinolines; Male; Methyltyrosines; Pimozide; Rats; Spiro Compounds; Stereotyped Behavior; Succinimides; Sulpiride; Thioridazine; Tranquilizing Agents | 1975 |
Differential sensitivity of two dopaminergic structures in rat brain to haloperidol and to clozapine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Chromatography, Gas; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Homovanillic Acid; Male; Olfactory Bulb; Rats; Stimulation, Chemical | 1975 |
Inhibition of circling behavior by neuroleptic drugs in mice with unilateral 6-hydroxydopamine lesions of the striatum.
Topics: Animals; Apomorphine; Basal Ganglia Diseases; Behavior; Biogenic Amines; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Diazepam; Dopamine; Haloperidol; Humans; Hydroxydopamines; Levodopa; Male; Metoclopramide; Mice; Motor Activity; Pentobarbital; Phenoxybenzamine; Pimozide; Promethazine; Stereotyped Behavior; Tranquilizing Agents | 1975 |
Effect of clozapine on the metabolism of serotonin in rat brain.
Topics: Animals; Brain; Brain Stem; Clozapine; Dibenzazepines; Haloperidol; Hydroxyindoleacetic Acid; Limbic System; Loxapine; Male; Rats; Serotonin; Thioridazine; Tryptophan; Tryptophan Hydroxylase | 1976 |
Action of neuroleptic agents on histamine-sensitive adenylate cyclase in rabbit cerebral cortex.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Brain; Cerebral Cortex; Chlorpromazine; Clozapine; Haloperidol; Histamine; Promethazine; Rabbits; Thioridazine; Tranquilizing Agents | 1976 |
Effects produced by acute and chronic treatment with granisetron alone or in combination with haloperidol on midbrain dopamine neurons.
Topics: Animals; Clozapine; Dopamine; Granisetron; Haloperidol; Indazoles; Male; Microelectrodes; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Substantia Nigra; Tegmentum Mesencephali | 1992 |
Electrophysiological profile of the new atypical neuroleptic, sertindole, on midbrain dopamine neurones in rats: acute and repeated treatment.
Topics: Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dextroamphetamine; Dopamine; Drug Administration Schedule; Electrophysiology; Haloperidol; Imidazoles; Indoles; Male; Mesencephalon; Neurons; Rats; Rats, Inbred Strains; Substantia Nigra; Tegmentum Mesencephali | 1992 |
A lever-release version of the conditioned avoidance response paradigm: effects of haloperidol, clozapine, sulpiride, and BMY-14802.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Haloperidol; Male; Psychotropic Drugs; Pyrimidines; Rats; Rats, Inbred Strains; Stereotyped Behavior; Sulpiride | 1992 |
Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Benzazepines; Cerebral Cortex; Clozapine; Corpus Striatum; Dopamine Antagonists; Gene Expression Regulation; Genes, fos; Haloperidol; Immunohistochemistry; Male; Molecular Weight; Nucleus Accumbens; Oxidopamine; Prosencephalon; Raclopride; Rats; Rats, Inbred Strains; Salicylamides | 1992 |
A ketamine-induced rat model of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dyskinesia, Drug-Induced; Haloperidol; Ketamine; Metoclopramide; Pharynx; Rats; Rats, Inbred Strains; Stereotyped Behavior; Tongue | 1992 |
Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell.
Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Clozapine; Dopamine; Haloperidol; Immobilization; Male; Methyltyrosines; Nucleus Accumbens; Rats; Rats, Inbred Strains; Reserpine; Serotonin; Stress, Psychological; Tyrosine 3-Monooxygenase | 1992 |
In vivo occupancy of dopamine receptors by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Humans; Rats; Receptors, Dopamine; Receptors, Serotonin; Spiperone | 1992 |
Typical and atypical neuroleptics antagonize MK-801-induced locomotion and stereotypy in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Salicylamides; Stereotyped Behavior | 1992 |
Evaluation of a stable CCK agonist (A68552) in conditioned avoidance responding in mice, rats, and primates: comparison with typical and atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Cholecystokinin; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Macaca fascicularis; Male; Mice; Peptide Fragments; Rats; Sulpiride | 1992 |
Amperozide and clozapine but not haloperidol or raclopride increase the secretion of oxytocin in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine Antagonists; Female; Haloperidol; Male; Oxytocin; Piperazines; Raclopride; Rats; Rats, Sprague-Dawley; Salicylamides; Serotonin Antagonists | 1992 |
Differential effects of amfonelic acid on the haloperidol- and clozapine-induced increase in extracellular DOPAC in the nucleus accumbens and the striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clozapine; Corpus Striatum; Drug Interactions; Haloperidol; Hydroxyindoleacetic Acid; Kinetics; Male; Membrane Potentials; Nalidixic Acid; Naphthyridines; Nucleus Accumbens; Rats; Rats, Inbred Strains; Ritanserin; Time Factors | 1992 |
Differential expression of c-fos and zif268 in rat striatum after haloperidol, clozapine, and amphetamine.
Topics: Amino Acid Isomerases; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Carrier Proteins; Clozapine; Corpus Striatum; Dextroamphetamine; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression; Genes, fos; Haloperidol; Immediate-Early Proteins; Immunoglobulin G; Male; Molecular Sequence Data; Neurons; Oligodeoxyribonucleotides; Peptides; Peptidylprolyl Isomerase; Rats; Rats, Inbred Strains; RNA; RNA, Messenger; Transcription Factors; Zinc Fingers | 1992 |
Effects of chronic treatment of haloperidol and clozapine on levels of G-protein subunits in rat striatum.
Topics: Amino Acid Sequence; Animals; Clozapine; Corpus Striatum; GTP-Binding Proteins; Haloperidol; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Signal Transduction | 1992 |
Clozapine's mechanisms of action: non-dopaminergic activity rather than anatomical selectivity.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine; Evoked Potentials; Haloperidol; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1992 |
Serotonergic drugs do not substitute for clozapine in clozapine-trained rats in a two-lever drug discrimination procedure.
Topics: Animals; Buspirone; Clozapine; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Psychological; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists; Tropanes | 1992 |
Shifts in covert visual attention in schizophrenic patients and normal controls.
Topics: Arousal; Attention; Clozapine; Haloperidol; Humans; Orientation; Psychiatric Status Rating Scales; Psychomotor Performance; Reaction Time; Schizophrenia; Schizophrenic Psychology; Visual Perception | 1992 |
Clozapine in the treatment of psychosis in an 82-year-old woman with tardive dyskinesia.
Topics: Age Factors; Aged; Aged, 80 and over; Clozapine; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Schizophrenia, Paranoid | 1992 |
Effects of amfonelic acid and GBR 12909 on the haloperidol- and clozapine-induced activation of dopamine neurons.
Topics: Animals; Clozapine; Dopamine; Haloperidol; Male; Nalidixic Acid; Naphthyridines; Neurons; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley | 1992 |
Chronic clozapine treatment down-regulates serotonin 5-HT-1c receptors in rat brain.
Topics: Animals; Brain; Clozapine; Down-Regulation; Haloperidol; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1992 |
Effect of haloperidol and clozapine on (+)SKF 10,047-induced dopamine release: role of 5-HT3 receptors.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Male; Nucleus Accumbens; Phenazocine; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1992 |
Seizure with low doses of clozapine.
Topics: Basal Ganglia Diseases; Clozapine; Haloperidol; Schizophrenia; Schizophrenic Psychology; Seizures | 1992 |
Effect of haloperidol and clozapine on the density of "perforated" synapses in caudate, nucleus accumbens, and medial prefrontal cortex.
Topics: Animals; Benzamides; Benzazepines; Brain; Caudate Nucleus; Clozapine; Dopamine Antagonists; Dyskinesia, Drug-Induced; Frontal Lobe; Haloperidol; Male; Microscopy, Electron; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine D1; Receptors, Dopamine D2; Synapses | 1992 |
Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum.
Topics: Animals; Autoradiography; Cloning, Molecular; Clozapine; Corpus Striatum; Dose-Response Relationship, Drug; Haloperidol; Male; Models, Genetic; Models, Neurological; Neurotensin; Nucleic Acid Hybridization; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Restriction Mapping; RNA, Messenger; Sulfur Radioisotopes; TATA Box; Transcription, Genetic | 1992 |
Extrastriatal dopamine D2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine.
Topics: Amphetamine; Animals; Autoradiography; Benzamides; Brain; Clozapine; Haloperidol; Male; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone | 1992 |
Tardive dyskinesia in the elderly patient.
Topics: Aged; Chlorpromazine; Chronic Disease; Clonazepam; Clozapine; Depressive Disorder; Desipramine; Diphenhydramine; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Neurologic Examination | 1992 |
Clozapine and haloperidol have differential effects on glutamic acid decarboxylase mRNA in the pallidal nuclei of the rat.
Topics: Animals; Clozapine; Corpus Striatum; Gene Expression; Globus Pallidus; Glutamate Decarboxylase; Haloperidol; Male; Nucleic Acid Hybridization; Rats; Rats, Inbred Strains; RNA, Messenger | 1992 |
Quantitative light microscopic demonstration of increased pallidal and striatal met5-enkephalin-like immunoreactivity in rats following chronic treatment with haloperidol but not with clozapine: implications for the pathogenesis of neuroleptic-induced mov
Topics: Animals; Clozapine; Corpus Striatum; Disease Models, Animal; Drug Administration Schedule; Dyskinesia, Drug-Induced; Enkephalin, Methionine; Globus Pallidus; Haloperidol; Immunoenzyme Techniques; Immunohistochemistry; Male; Models, Neurological; Organ Specificity; Rats; Rats, Inbred Strains; Water | 1992 |
Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens, and striatum: a comparison of acute clozapine and haloperidol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biogenic Monoamines; Brain Chemistry; Clozapine; Corpus Striatum; Dopamine; Frontal Lobe; Haloperidol; Homovanillic Acid; Male; Nucleus Accumbens; Pargyline; Rats; Rats, Inbred Strains | 1992 |
Clozapine decreases enkephalin mRNA in rat striatum.
Topics: Animals; Basal Ganglia Diseases; Clozapine; Corpus Striatum; Depression, Chemical; Efferent Pathways; Enkephalins; Gene Expression Regulation; Globus Pallidus; Haloperidol; Male; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains | 1992 |
Selective antidopaminergic effects of S(+)N-n-propylnoraporphines in limbic versus extrapyramidal sites in rat brain: comparisons with typical and atypical antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dibenzothiazepines; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Limbic System; Male; Motor Activity; Pyramidal Tracts; Quetiapine Fumarate; Rats; Rats, Inbred Strains | 1991 |
Use of amfonelic acid to discriminate between classical and atypical neuroleptics and neurotensin: an in vivo voltammetric study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Cerebral Ventricles; Clozapine; Corpus Striatum; Electrochemistry; Haloperidol; Injections, Intraventricular; Male; Nalidixic Acid; Naphthyridines; Neurotensin; Perphenazine; Rats; Rats, Inbred Strains; Thioridazine | 1991 |
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clozapine; Dopamine Agents; Dopamine Antagonists; Drug Interactions; Ergolines; Haloperidol; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1991 |
Clozapine attenuates N-methyl-D-aspartate receptor complex-mediated responses in vivo: tentative evidence for a functional modulation by a noradrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Clozapine; Cyclic GMP; Dioxanes; Haloperidol; Harmaline; Histamine H2 Antagonists; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Methamphetamine; Mice; Norepinephrine; Pentylenetetrazole; Receptors, N-Methyl-D-Aspartate; Ritanserin; Serine; Tropisetron | 1991 |
Effect of ritanserin on the interaction of amfonelic acid and neuroleptic-induced striatal dopamine metabolism.
Topics: Animals; Antipsychotic Agents; Chromatography, High Pressure Liquid; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Male; Nalidixic Acid; Naphthyridines; Rats; Rats, Inbred Strains; Ritanserin; Serotonin Antagonists; Substantia Nigra; Synaptic Transmission | 1991 |
Effects of haloperidol and clozapine on preprotachykinin-A messenger RNA, tachykinin tissue levels, release and neurokinin-1 receptors in the striato-nigral system.
Topics: Animals; Binding, Competitive; Chromatography, High Pressure Liquid; Clozapine; Corpus Striatum; Dibenzazepines; Female; Haloperidol; Neural Pathways; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurokinin-2; Receptors, Neurotransmitter; RNA, Messenger; Substance P; Substantia Nigra; Tachykinins | 1990 |
Differential effects of repeated treatment with haloperidol and clozapine on dopamine release and metabolism in the striatum and the nucleus accumbens.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Extracellular Space; Haloperidol; Hydroxyindoleacetic Acid; Injections, Subcutaneous; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains | 1991 |
The effects of typical and atypical neuroleptics on mitogen-induced T lymphocyte responsiveness.
Topics: Adult; Antigens, Differentiation; Antipsychotic Agents; CD5 Antigens; Clozapine; Female; Fluphenazine; Haloperidol; Humans; Lymphocyte Activation; Male; Schizophrenia; Schizophrenic Psychology; T-Lymphocytes; Thioridazine | 1991 |
Evidence for ultrastructural changes in cortical axodendritic synapses following long-term treatment with haloperidol or clozapine.
Topics: Animals; Axons; Cerebral Cortex; Clozapine; Dendrites; Haloperidol; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Synapses; Time Factors | 1991 |
Changes of brain gangliosides in the frontal cortex of rats chronically treated with amphetamine, clozapine, haloperidol and ethanol.
Topics: Amphetamine; Animals; Cerebral Cortex; Chromatography, Thin Layer; Clozapine; Ethanol; Gangliosides; Haloperidol; Male; Rats; Rats, Inbred Strains | 1991 |
Muscarinic antagonists attenuate the increase in accumbens and striatum dopamine metabolism produced by clozapine but not by haloperidol.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Atropine; Clozapine; Corpus Striatum; Dopamine; Electric Stimulation; Extracellular Space; Haloperidol; Male; Nucleus Accumbens; Parasympatholytics; Rats; Rats, Inbred Strains; Scopolamine | 1991 |
Positron emission tomography with (18F)methylspiperone demonstrates D2 dopamine receptor binding differences of clozapine and haloperidol.
Topics: Adult; Aged; Brain Chemistry; Clozapine; Female; Fluorine Radioisotopes; Glucose; Haloperidol; Humans; Male; Middle Aged; Receptors, Dopamine; Receptors, Dopamine D2; Schizophrenia; Spiperone; Tomography, Emission-Computed; Tomography, X-Ray Computed | 1991 |
Multiple neurochemical action of clozapine: a quantitative autoradiographic study of DA2, opiate and benzodiazepine receptors in the rat brain after long-term treatment.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Clozapine; Down-Regulation; Haloperidol; Limbic System; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, GABA-A; Receptors, Opioid | 1991 |
Comparison of withdrawal of typical and atypical antipsychotic drugs: a case study.
Topics: Acute Disease; Adult; Ambulatory Care; Clozapine; Haloperidol; Hospitalization; Humans; Male; Psychiatric Status Rating Scales; Psychoses, Substance-Induced; Schizophrenia; Schizophrenic Psychology; Substance Withdrawal Syndrome | 1991 |
The CCK-A receptor antagonist devazepide but not the CCK-B receptor antagonist L-365,260 reverses the effects of chronic clozapine and haloperidol on midbrain dopamine neurons.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Clozapine; Devazepide; Dopamine; Haloperidol; Male; Mesencephalon; Neurons; Phenylurea Compounds; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Reference Values | 1991 |
Calcitonin gene-related peptide in the amygdaloid complex of the rat: immunohistochemical and quantitative distribution, and drug effects on calcium dependent, potassium-evoked in vitro release.
Topics: Amygdala; Animals; Calcitonin Gene-Related Peptide; Calcium; Chromatography, High Pressure Liquid; Clozapine; Female; Haloperidol; Immunohistochemistry; Potassium; Radioimmunoassay; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Effects of acute and chronic clozapine and haloperidol administration on 3-methoxytyramine accumulation in rat prefrontal cortex, nucleus accumbens and striatum.
Topics: Animals; Brain; Cerebral Cortex; Chromatography, Gas; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains | 1991 |
Effects of antipsychotic drugs on 5-HT2 receptors in the medial prefrontal cortex: microiontophoretic studies.
Topics: Amphetamines; Animals; Antipsychotic Agents; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Evoked Potentials; Frontal Lobe; Haloperidol; Iontophoresis; Male; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone | 1990 |
Amperozide and conditioned behaviour in rats: potentiation by classical neuroleptics and alpha-methylparatyrosine.
Topics: alpha-Methyltyrosine; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Butyrophenones; Chlorpromazine; Clozapine; Conditioning, Operant; Drug Synergism; Female; Food; Haloperidol; Male; Methyltyrosines; Piperazines; Psychotropic Drugs; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1990 |
Atypical neuroleptics suppress dopaminergic behavioral supersensitivity.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Cyproheptadine; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Ritanserin; Serotonin Antagonists; Sulpiride; Thioridazine | 1990 |
Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dialysis; Dopamine; Frontal Lobe; Haloperidol; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Sulpiride | 1990 |
Differential effects of chronic treatment with haloperidol and clozapine on the level of preprosomatostatin mRNA in the striatum, nucleus accumbens, and frontal cortex of the rat.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dibenzazepines; Frontal Lobe; Gene Expression Regulation; Haloperidol; Male; Nucleic Acid Hybridization; Nucleus Accumbens; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Somatostatin | 1990 |
Lack of effect of chronic dopamine receptor blockade on D2 dopamine receptor mRNA level.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Blotting, Northern; Clozapine; Corpus Striatum; DNA Probes; Dopamine Antagonists; Haloperidol; Male; Quinolines; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; RNA, Messenger; Salicylamides | 1990 |
One year of continuous treatment with haloperidol or clozapine fails to induce a hypersensitive response of caudate putamen neurons to dopamine D1 and D2 receptor agonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Administration, Oral; Animals; Clozapine; Dibenzazepines; Dopamine Agents; Drug Interactions; Ergolines; Haloperidol; Male; Neurons; Putamen; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1990 |
Behavioural pharmacology of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro- 1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrolidine maleate, a compound interacting with dopaminergic and serotonergic receptors.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Catalepsy; Chlorpromazine; Clozapine; Conflict, Psychological; Dibenzocycloheptenes; Dibenzoxepins; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Male; Mice; Mice, Inbred ICR; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Stereotyped Behavior | 1990 |
MK-801-induced stereotypy and its antagonism by neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzazepines; Dibenzocycloheptenes; Dizocilpine Maleate; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereotyped Behavior | 1990 |
Chronic administration of typical, but not atypical neuroleptics induce persisting alterations in rest-activity cycles in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Drinking; Female; Fluphenazine; Haloperidol; Motor Activity; Raclopride; Rats; Rats, Inbred Strains; Salicylamides | 1990 |
Autoradiographic analysis of regional alterations in brain receptors following chronic administration and withdrawal of typical and atypical neuroleptics in rats.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Dyskinesia, Drug-Induced; Female; Haloperidol; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, GABA-A; Receptors, Muscarinic; Receptors, Neurotransmitter; Salicylamides; Up-Regulation | 1990 |
DA2/NT receptor balance in the mesostriatal and mesolimbocortical systems after chronic treatment with typical and atypical neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Cerebral Cortex; Chlorpromazine; Clozapine; Corpus Striatum; Haloperidol; Limbic System; Male; Neurotensin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotensin; Receptors, Neurotransmitter; Thioridazine; Time Factors | 1990 |
Effect of clozapine on psychogenic polydipsia in chronic schizophrenia.
Topics: Adult; Clozapine; Drinking; Haloperidol; Humans; Loxapine; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Thirst | 1991 |
Regional specific effects of clozapine and haloperidol on GABA and dopamine release in rat basal ganglia.
Topics: Animals; Basal Ganglia; Clozapine; Corpus Striatum; Dialysis; Dopamine; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Male; Rats; Tetrodotoxin | 1990 |
Utilization of microdialysis for assessing the release of mesotelencephalic dopamine following clozapine and other antipsychotic drugs.
Topics: Animals; Cerebral Cortex; Clozapine; Corpus Striatum; Dialysis; Dopamine; Haloperidol; Mesencephalon; Microchemistry; Nucleus Accumbens; Organ Specificity; Rats; Sulpiride; Telencephalon | 1990 |
Effect of amperozide on the dopamine synthesis activity in the tuberoinfundibular neurons.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Clozapine; Dihydroxyphenylalanine; Dopamine; Haloperidol; Male; Median Eminence; Neurons; Piperazines; Psychotropic Drugs; Rats; Rats, Inbred Strains | 1990 |
Neurochemical effects of chronic co-administration of ritanserin and haloperidol: comparison with clozapine effects.
Topics: Animals; Clozapine; Dopamine; Drug Combinations; Haloperidol; Male; Nucleus Accumbens; Piperidines; Rats; Rats, Inbred Strains; Ritanserin; Serotonin; Substantia Nigra; Time Factors | 1990 |
The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clozapine; Corpus Striatum; Dialysis; Dibenzazepines; Dopamine; Haloperidol; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Stereotaxic Techniques | 1990 |
Clozapine fails to prevent the development of haloperidol-induced behavioral hypersensitivity in a cotreatment paradigm.
Topics: Animals; Apomorphine; Behavior, Animal; Binding, Competitive; Brain Chemistry; Clozapine; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Male; Rats; Rats, Inbred Strains; Spiperone; Stereotyped Behavior; Thioridazine | 1990 |
Chronic treatment with clozapine or haloperidol differentially regulates dopamine and serotonin receptors in rat brain.
Topics: Animals; Autoradiography; Brain; Caudate Nucleus; Clozapine; Haloperidol; Male; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin | 1990 |
Quantitative analyses of plasma cholinesterase isozymes in haloperidol-treated rats.
Topics: Acetylcholinesterase; Animals; Clozapine; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Haloperidol; Imipramine; Isoenzymes; Male; Rats; Rats, Inbred Strains | 1990 |
High-performance liquid chromatographic procedure for the determination of clozapine, haloperidol, droperidol and several benzodiazepines in plasma.
Topics: Animals; Benzodiazepines; Chromatography, High Pressure Liquid; Clozapine; Dibenzazepines; Droperidol; Haloperidol; Humans; Rats | 1990 |
Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test.
Topics: Animals; Chlordiazepoxide; Clozapine; Defecation; Dibenzazepines; Exploratory Behavior; Haloperidol; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulpiride | 1990 |
Differential effects of haloperidol and clozapine on the reinforcing efficacy of food reward in an alleyway reacquisition paradigm.
Topics: Animals; Clozapine; Dibenzazepines; Extinction, Psychological; Food; Haloperidol; Male; Motor Activity; Rats; Rats, Inbred Strains; Reinforcement, Psychology; Reward | 1990 |
Comparison of chronic administration of haloperidol and the atypical neuroleptics, clozapine and raclopride, in an animal model of tardive dyskinesia.
Topics: Animals; Behavior, Animal; Body Weight; Clozapine; Dibenzazepines; Disease Models, Animal; Drinking; Dyskinesia, Drug-Induced; Female; Fourier Analysis; Haloperidol; Raclopride; Rats; Rats, Inbred Strains; Salicylamides | 1990 |
Chronic haloperidol and clozapine differentially affect dynorphin peptides and substance P in basal ganglia of the rat.
Topics: Animals; Basal Ganglia; Body Weight; Clozapine; Dibenzazepines; Dynorphins; Haloperidol; Injections, Intraperitoneal; Male; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Substance P | 1986 |
Behavioral studies with anxiolytic drugs. V. Behavioral and in vivo neurochemical analyses in pigeons of drugs that increase punished responding.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Anxiety Agents; Buspirone; Chlordiazepoxide; Clozapine; Columbidae; Conditioning, Operant; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Punishment; Pyrimidines | 1988 |
[Severe late dyskinesia caused by neuroleptics in a young female. Follow-up and treatment].
Topics: Adolescent; Carbamazepine; Clozapine; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Follow-Up Studies; Haloperidol; Humans; Meclofenoxate; Neuroleptic Malignant Syndrome; Schizophrenia; Schizophrenic Psychology; Tiapamil Hydrochloride | 1989 |
Effects of acute and chronic treatments with clozapine and haloperidol on serotonin (5-HT2) and dopamine (D2) receptors in the rat brain.
Topics: Animals; Autoradiography; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Image Processing, Computer-Assisted; Male; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Septal Nuclei; Spiperone; Time Factors | 1989 |
Striatal and frontal cortex binding of 11-C-labelled clozapine visualized by positron emission tomography (PET) in drug-free schizophrenics and healthy volunteers.
Topics: Adult; Carbon Radioisotopes; Clozapine; Corpus Striatum; Dibenzazepines; Frontal Lobe; Haloperidol; Humans; Male; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Schizophrenia; Tomography, Emission-Computed | 1989 |
Dopamine receptor occupancy in vivo: measurement using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ).
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Clozapine; Corpus Striatum; Ergolines; Haloperidol; Male; Quinolines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1989 |
Blockade of both D1- and D2-dopamine receptors inhibits amphetamine-induced ascorbate release in the neostriatum.
Topics: Amphetamines; Animals; Antipsychotic Agents; Ascorbic Acid; Benzazepines; Clozapine; Corpus Striatum; Electrochemistry; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1989 |
Differential effects of dopamine receptor antagonists on the sexual behavior of male rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Ejaculation; Female; Haloperidol; Male; Metoclopramide; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal; Sulpiride | 1989 |
Regional differences in the induction of behavioral supersensitivity by prolonged treatment with atypical neuroleptics.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Body Weight; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Humans; Injections; Metoclopramide; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Stereotyped Behavior; Sulpiride | 1989 |
Blockade of acquisition of one-way conditioned avoidance responding by haloperidol and metoclopramide but not by thioridazine or clozapine: implications for screening new antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Dibenzazepines; Drug Evaluation, Preclinical; Haloperidol; Male; Metoclopramide; Rats; Thioridazine | 1989 |
One year treatment with haloperidol or clozapine fails to alter neostriatal D1- and D2-dopamine receptor sensitivity in the rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Colforsin; Corpus Striatum; Cyclic AMP; Dibenzazepines; Drug Synergism; Ergolines; Haloperidol; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1989 |
CI-943, a potential antipsychotic agent. II. Neurochemical effects.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain Chemistry; Clozapine; Dopamine; Haloperidol; Imidazoles; In Vitro Techniques; Male; Mice; Neurotransmitter Agents; Norepinephrine; Prolactin; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin; Spiperone | 1989 |
Differential effect of typical and atypical antipsychotic drugs on the suppressant action of 2-methylserotonin on medical prefrontal cortical cells: a microiontophoretic study.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Haloperidol; Iontophoresis; Male; Neurons; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Amphetamine stimulation of glutaminase is blocked by neuroleptics.
Topics: Amphetamine; Animals; Antipsychotic Agents; Brain; Butaclamol; Chlorpromazine; Clozapine; Enzyme Activation; Glutaminase; Haloperidol; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Stereoisomerism | 1985 |
Role of dopaminergic mechanisms in the central amygdalar nucleus in the regulation of stress-induced gastric ulcer formation in rats.
Topics: Amygdala; Animals; Clozapine; Dibenzazepines; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Peptic Ulcer; Rats; Rats, Inbred Strains; Stress, Physiological | 1989 |
Haloperidol and clozapine: differential effects on the sensitivity of caudate-putamen neurons to dopamine agonists and cholecystokinin following one month continuous treatment.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Animals; Benzazepines; Cholecystokinin; Clozapine; Corpus Striatum; Dibenzazepines; Ergolines; Haloperidol; Male; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sincalide | 1989 |
Clozapine and haloperidol in the amygdaloid complex: differential effects on dopamine transmission with long-term treatment.
Topics: Acetylcholine; Amygdala; Animals; Clozapine; Dibenzazepines; Dopamine; Haloperidol; Long-Term Care; Male; Neurons; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Synaptic Transmission | 1988 |
Selective inhibition of mesolimbic dopamine release following chronic administration of clozapine: involvement of alpha 1-noradrenergic receptors demonstrated by in vivo voltammetry.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Limbic System; Male; Nucleus Accumbens; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reference Values; Septal Nuclei | 1988 |
Effects of neuroleptics on rate and duration of operant versus reflexive licking in rats.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Conditioning, Operant; Haloperidol; Male; Rats; Rats, Inbred Strains; Reflex; Time Factors | 1985 |
Mesolimbic dopamine function is not altered during continuous chronic treatment of rats with typical or atypical neuroleptic drugs.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Clozapine; Dopamine; Haloperidol; Male; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Receptors, Dopamine; Septal Nuclei; Sulpiride | 1985 |
Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons.
Topics: Anesthetics; Animals; Antipsychotic Agents; Biomechanical Phenomena; Chloral Hydrate; Clozapine; Dibenzazepines; Dioxanes; Dopamine; Drug Combinations; Haloperidol; Idazoxan; Male; Mesencephalon; Neurons; Prazosin; Rats; Rats, Inbred Strains; Trihexyphenidyl | 1985 |
Antagonism of N-methyl-D-aspartate-induced transmitter release in the rat striatum by phencyclidine-like drugs and its relationship to turning behavior.
Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Aspartic Acid; Benzomorphans; Chlorpromazine; Clozapine; Corpus Striatum; Cyclazocine; Dioxolanes; Dopamine; Haloperidol; Ketamine; Male; Mathematics; Motor Activity; N-Methylaspartate; Phencyclidine; Posture; Rats; Rats, Inbred Strains; Substantia Nigra | 1985 |
Presynaptic dopamine autoreceptors control tyrosine hydroxylase activation in depolarized striatal dopaminergic terminals.
Topics: Amphetamine; Animals; Bucladesine; Cerebral Cortex; Clozapine; Corpus Striatum; Dopamine; Enzyme Activation; Haloperidol; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Sulpiride; Synapses; Synaptosomes; Tyrosine 3-Monooxygenase; Veratridine | 1986 |
Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex.
Topics: 5,7-Dihydroxytryptamine; Animals; Antipsychotic Agents; Cerebral Cortex; Chlorpromazine; Clozapine; Female; Haloperidol; Imipramine; Ketanserin; Loxapine; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Sulpiride | 1986 |
Locus coeruleus norepinephrine-containing neurons: effects produced by acute and subchronic treatment with antipsychotic drugs and amphetamine.
Topics: Action Potentials; Amphetamine; Animals; Antipsychotic Agents; Clozapine; Dibenzazepines; Electric Stimulation; Haloperidol; Locus Coeruleus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Effect of neuroleptics and of potential new antipsychotic agents (MJ 13859-1 and MJ 13980-1) on a monkey model of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Cebus; Chlorpromazine; Clozapine; Dyskinesia, Drug-Induced; Female; Haloperidol; Motor Activity; Posture; Spiro Compounds; Thioridazine | 1986 |
Intrastriatal injection of DL-2-amino-5-phosphonovaleric acid (AP-5) induces sniffing stereotypy that is antagonized by haloperidol and clozapine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Clozapine; Corpus Striatum; Dextroamphetamine; Dibenzazepines; Grooming; Haloperidol; Injections; Male; Rats; Rats, Inbred Strains; Stereotyped Behavior; Valine | 1986 |
[Structure of the anxious-delusional syndrome of schizophrenic patients during treatment with anxiolytics].
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinones; Clozapine; Delusions; Haloperidol; Humans; Male; Middle Aged; Neurocognitive Disorders; Schizophrenia; Syndrome; Trifluoperazine | 1986 |
3-Methoxytyramine accumulation: effects of typical neuroleptics and various atypical compounds.
Topics: 4-Butyrolactone; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Buspirone; Carbazoles; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Fluphenazine; Haloperidol; Male; Molindone; Pargyline; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Regression Analysis | 1986 |
[Changes in the health state of schizophrenic patients in neuroleptic therapy].
Topics: Adolescent; Adult; Antipsychotic Agents; Attitude to Health; Clozapine; Dyskinesia, Drug-Induced; Haloperidol; Humans; Middle Aged; Motor Skills; Schizophrenia; Schizophrenic Psychology | 1986 |
In vivo potencies of antipsychotic drugs in blocking alpha 1 noradrenergic and dopamine D2 receptors: implications for drug mechanisms of action.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; Clozapine; Fluphenazine; Haloperidol; Kinetics; Male; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Thioridazine | 1986 |
Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Male; Metoclopramide; Nucleus Accumbens; Promethazine; Rats; Rats, Inbred Strains; Septal Nuclei; Thioridazine | 1987 |
[Neuroleptic modification of basic schizophrenic disorders].
Topics: Adolescent; Adult; Antipsychotic Agents; Clozapine; Dyskinesia, Drug-Induced; Haloperidol; Humans; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1987 |
Antagonism of AP-5- and amphetamine-induced behaviour by timelotem as compared with clozapine and haloperidol.
Topics: 2-Amino-5-phosphonovalerate; Amphetamine; Animals; Behavior, Animal; Benzodiazepines; Clozapine; Dibenzazepines; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Stereotyped Behavior; Valine | 1987 |
Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopamine neurons in the rat: acute and chronic studies.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Clozapine; Dopamine; Electrophysiology; Haloperidol; Male; Neurons; Pyrimidines; Rats; Rats, Inbred Strains | 1988 |
Comparative study of schizophrenic patients relapsed on and off medication.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Delayed-Action Preparations; Female; Haloperidol; Humans; Life Change Events; Middle Aged; Psychiatric Status Rating Scales; Recurrence; Risk Factors; Schizophrenia; Schizophrenic Psychology | 1987 |
The paw test: a behavioural paradigm for differentiating between classical and atypical neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Forelimb; Haloperidol; Hindlimb; Male; Metoclopramide; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Thioridazine | 1987 |
The Paw test: an animal model for neuroleptic drugs which fulfils the criteria for pharmacological isomorphism.
Topics: Animals; Antipsychotic Agents; Clozapine; Drug Evaluation, Preclinical; Forelimb; Haloperidol; Hindlimb; Male; Models, Biological; Motor Activity; Rats; Rats, Inbred Strains; Scopolamine | 1988 |
Effects of neuroleptics on glutaminase from rat synaptosomes.
Topics: Amygdala; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Glutaminase; Haloperidol; Hippocampus; Male; Phosphates; Rats; Rats, Inbred Strains; Synaptosomes | 1988 |
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Body Temperature; Butyrophenones; Chlorpromazine; Clozapine; Corticosterone; Haloperidol; Male; Neurosecretory Systems; Pyrazines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1988 |
Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity.
Topics: Amphetamines; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; DOM 2,5-Dimethoxy-4-Methylamphetamine; Electric Stimulation; Evoked Potentials; Haloperidol; Locus Coeruleus; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sciatic Nerve; Spiperone; Sulpiride | 1988 |
Effects of acute and chronic clozapine and haloperidol on in vitro release of acetylcholine and dopamine from striatum and nucleus accumbens.
Topics: Acetylcholine; Amphetamine; Animals; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Electric Stimulation; Haloperidol; In Vitro Techniques; Male; Nalidixic Acid; Naphthyridines; Nucleus Accumbens; Rats; Rats, Inbred Strains; Septal Nuclei; Tetrahydronaphthalenes | 1989 |
Effects of fluperlapine on dopaminergic systems in rat brain.
Topics: Animals; Brain; Brain Chemistry; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Homovanillic Acid; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2 | 1986 |
Inhibition of the electrically evoked release of [3H]acetylcholine in rat striatal slices: an experimental model for drugs that enhance dopaminergic neurotransmission.
Topics: Acetylcholine; Amphetamine; Animals; Chlorpromazine; Clozapine; Cocaine; Corpus Striatum; Dopamine; Electric Stimulation; Haloperidol; Male; Nomifensine; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpiride; Synaptic Transmission | 1985 |
Comparison of circling induced by unilateral intrastriatal microinjections of haloperidol, clozapine and CCK-8 in rats.
Topics: Animals; Clozapine; Corpus Striatum; Dextroamphetamine; Dibenzazepines; Dopamine; Haloperidol; Male; Microinjections; Motor Activity; Rats; Rats, Inbred Strains; Sincalide; Synaptic Transmission | 1986 |
Differential effects of haloperidol, clozapine, and fluperlapine on tuberoinfundibular dopamine neurons and prolactin secretion in the rat.
Topics: Animals; Clozapine; Dibenzazepines; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Hypothalamus; Median Eminence; Neurons; Prolactin; Rats; Rats, Inbred Strains; Time Factors | 1987 |
Differential alteration of striatal D-1 and D-2 receptors induced by the long-term administration of haloperidol, sulpiride or clozapine to rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Long-Term Care; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Spiperone; Stereotyped Behavior; Sulpiride; Thioxanthenes | 1985 |
Behavioral screen for antidepressants: the effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule.
Topics: Animals; Antidepressive Agents; Bupropion; Clozapine; Drug Evaluation, Preclinical; Electroshock; Fluoxetine; Haloperidol; Male; Propiophenones; Rats; Rats, Inbred Strains; Reinforcement Schedule; Trazodone; Zimeldine | 1985 |
Atypical antipsychotic drugs block selective components of amphetamine-induced stereotypy.
Topics: Animals; Behavior, Animal; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Rats; Rats, Inbred Strains; Stereotyped Behavior; Thioridazine | 1988 |
Differential effects of antipsychotic drugs on the neurotensin concentration of discrete rat brain nuclei.
Topics: Animals; Brain; Brain Chemistry; Clozapine; Dibenzazepines; Haloperidol; Male; Neurotensin; Rats; Rats, Inbred Strains | 1988 |
[Depressive syndromes within the scope of schizophrenic diseases].
Topics: Clozapine; Depressive Disorder; Haloperidol; Humans; Risk; Schizophrenia; Schizophrenic Psychology | 1986 |
Lack of effects of apomorphine, haloperidol and clozapine on the synthesis and utilization of brain GABA.
Topics: Animals; Apomorphine; Brain; Clozapine; Corpus Striatum; Dibenzazepines; gamma-Aminobutyric Acid; Haloperidol; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1987 |
Differential effects of acute clozapine and haloperidol on the activity of ventral tegmental (A10) and nigrostriatal (A9) dopamine neurons.
Topics: Animals; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Iontophoresis; Male; Microinjections; Neural Pathways; Rats; Rats, Inbred Strains; Substantia Nigra; Tegmentum Mesencephali | 1987 |
Electrophysiological evaluation of a partial agonist of dopamine receptors.
Topics: Amphetamine; Animals; Apomorphine; Clozapine; Dose-Response Relationship, Drug; Electric Stimulation; Ergolines; Haloperidol; Lisuride; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1987 |
[Value of neuroleptic therapy in the self assessment of schizophrenic patients].
Topics: Clozapine; Depressive Disorder; Dibenzazepines; Dyskinesia, Drug-Induced; Haloperidol; Humans; Psychiatric Status Rating Scales; Psychometrics; Schizophrenia; Schizophrenia, Paranoid; Schizophrenic Psychology | 1987 |
[Effect of haloperidol and clozapine on the bioelectric activity of the human cerebral cortex].
Topics: Cerebral Cortex; Clozapine; Cortical Synchronization; Dibenzazepines; Electroencephalography; Haloperidol; Humans; Stimulation, Chemical | 1986 |
Differential alterations in striatal acetylcholine function in rats during 12 months' continuous administration of haloperidol, sulpiride, or clozapine.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Clozapine; Corpus Striatum; Dibenzazepines; Dyskinesia, Drug-Induced; Haloperidol; Male; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Sulpiride | 1986 |
Differential response of amygdaloid neurons to clozapine and haloperidol: effects of repeated administration.
Topics: Amygdala; Animals; Clozapine; Dextroamphetamine; Dibenzazepines; Haloperidol; Male; Neurons; Rats; Rats, Inbred Strains | 1986 |
[Effect of neuroleptics on the epileptic process].
Topics: Anticonvulsants; Cerebral Cortex; Clozapine; Cortical Synchronization; Dibenzazepines; Epilepsy; Haloperidol; Humans; Respiration | 1986 |
[Results of treatment with clozapine in schizophrenic adolescents].
Topics: Adolescent; Clozapine; Dibenzazepines; Follow-Up Studies; Haloperidol; Humans; Residential Treatment; Schizophrenia; Schizophrenic Psychology | 1986 |
Alterations in cerebral glutamic acid decarboxylase and 3H-flunitrazepam binding during continuous treatment of rats for up to 1 year with haloperidol, sulpiride or clozapine.
Topics: Animals; Body Weight; Brain; Clozapine; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Haloperidol; Kinetics; Male; Psychotropic Drugs; Rats; Rats, Inbred Strains; Sulpiride; Time Factors | 1987 |
Discriminative stimulus properties of buspirone in the pigeon.
Topics: Animals; Apomorphine; Buspirone; Clozapine; Columbidae; Discrimination Learning; Haloperidol; Methysergide; Midazolam; Pyrimidines; Serotonin | 1987 |
Classification of sulpiride, clozapine and haloperidol by toposelective recording from different brain structures in the immobilized rat (stereo-EEG).
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dibenzazepines; Electroencephalography; Haloperidol; Male; Motor Cortex; Rats; Reticular Formation; Somatosensory Cortex; Sulpiride | 1985 |
Chronic treatment with clozapine, unlike haloperidol, does not induce changes in striatal D-2 receptor function in the rat.
Topics: Acetylcholine; Animals; Apomorphine; Body Weight; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Mastication; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Thioxanthenes; Tritium | 1985 |
[Schizophrenically disordered time perception and its modification by neuroleptics].
Topics: Adolescent; Adult; Clozapine; Dibenzazepines; Haloperidol; Humans; Middle Aged; Schizophrenia; Schizophrenic Psychology; Time Perception | 1985 |
The effects of clozapine on shuttle-box avoidance responding in rats: comparisons with haloperidol and chlordiazepoxide.
Topics: Animals; Avoidance Learning; Chlordiazepoxide; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Electroshock; Haloperidol; Male; Rats; Rats, Inbred Strains | 1985 |
Effects of haloperidol and low dose clozapine on the acetylcholine turnover rate in rat forebrain structures.
Topics: Acetylcholine; Animals; Brain; Choline; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Male; Nucleus Accumbens; Olfactory Bulb; Rats; Rats, Inbred Strains; Serotonin Antagonists | 1985 |
Antischizophrenic drugs: affinity for muscarinic cholinergic receptor sites in the brain predicts extrapyramidal effects.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Binding, Competitive; Brain; Chlorpromazine; Clozapine; Fluphenazine; Guinea Pigs; Haloperidol; Haplorhini; Humans; In Vitro Techniques; Perphenazine; Phenothiazines; Promazine; Rats; Receptors, Cholinergic; Schizophrenia; Thioridazine; Trifluoperazine; Triflupromazine | 1974 |
Direct effect of neuroleptics on glutamate release.
Topics: Amygdala; Animals; Antipsychotic Agents; Atropine; Avoidance Learning; Butaclamol; Calcium; Chlorpromazine; Clozapine; Glutamates; Glutamic Acid; Glutamine; Haloperidol; In Vitro Techniques; Male; Rats; Synaptosomes | 1984 |
Inhibition of apomorphine-, bromocriptine- and lergotrile-induced circling behaviour in rats by subsequent haloperidol administration.
Topics: Animals; Apomorphine; Behavior; Bromocriptine; Clozapine; Ergolines; Haloperidol; Humans; Male; Rats; Stereotyped Behavior; Time Factors | 1980 |
Effect of neuroleptics and tricyclic antidepressants upon d-amphetamine discrimination.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dextroamphetamine; Discrimination, Psychological; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imipramine; Male; Nortriptyline; Promethazine; Rats; Sodium Chloride; Thioridazine; Trifluoperazine | 1980 |
Acute effects of neuroleptics on brain self-stimulation thresholds in rats.
Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Haloperidol; Loxapine; Male; Pimozide; Rats; Self Stimulation | 1980 |
Clozapine's anti-acetylcholine property modulates its antistereotypic action in the mesolimbic system.
Topics: Acetylcholine; Animals; Behavior; Clozapine; Dextroamphetamine; Dibenzazepines; Electric Stimulation; Electrodes, Implanted; Haloperidol; Humans; Limbic System; Male; Oxotremorine; Physostigmine; Rats; Stereotyped Behavior | 1980 |
Neuroleptic-induced acute dyskinesias in squirrel monkeys: correlation with propensity to cause extrapyramidal side effects.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Baclofen; Basal Ganglia Diseases; Clozapine; Diazepam; Dyskinesia, Drug-Induced; Haloperidol; Haplorhini; Male; Saimiri | 1980 |
Regulation of tyrosine hydroxylase after chronic treatment with classic and atypical antischizophrenic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Corpus Striatum; Haloperidol; Male; Nucleus Accumbens; Rats; Sulpiride; Time Factors; Tyrosine 3-Monooxygenase | 1980 |
Behavioral, anti-dopaminergic, and prohypnotic effects of neuroleptics during and after prolonged treatment.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Clozapine; Dopamine; Dopamine Antagonists; Drug Tolerance; Female; Haloperidol; Hypnotics and Sedatives; Male; Mice; Motor Activity; Oxazoles; Piperazines; Receptors, Dopamine; Time Factors | 1980 |
Morphological changes of pigeon crop-sac mucosa and pituitary lactotrophs after systemic and intraventricular administration of neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Clozapine; Columbidae; Crop, Avian; Female; Haloperidol; Mucous Membrane; Pituitary Gland, Anterior; Prolactin; Reserpine; Sulpiride | 1980 |
Central levels of noradrenaline, 3-methoxy-4-hydroxyphenylethyleneglycol and cyclic AMP in the rat after activation of locus coeruleus neurons: influence of single and repeated neuroleptic treatment.
Topics: Animals; Antipsychotic Agents; Biotransformation; Central Nervous System; Clozapine; Cyclic AMP; Glycols; Haloperidol; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Rats | 1980 |
Differential actions of classical and atypical antipsychotic drugs on spontaneous neuronal activity in the amygdaloid complex.
Topics: Amygdala; Animals; Antipsychotic Agents; Clozapine; Dextroamphetamine; Drug Interactions; Electric Stimulation; Haloperidol; Male; Neurons; Rats | 1981 |
The effect of catecholamine receptor antagonists on ethanol-induced locomotor stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Ethanol; Female; Haloperidol; Locomotion; Mice; Phenoxybenzamine; Pimozide; Receptors, Adrenergic; Receptors, Dopamine; Yohimbine | 1981 |
Hypokinesia in mice and catalepsy in rats elicited by morphine associated with antidopaminergic agents, including atypical neuroleptics.
Topics: alpha-Methyltyrosine; Animals; Antipsychotic Agents; Apomorphine; Catalepsy; Clozapine; Haloperidol; Humans; Male; Methyltyrosines; Mice; Morphine; Motor Activity; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Thioridazine | 1981 |
[Dynamics of integral parameters of the background EEG during treatment with neuroleptics].
Topics: Antipsychotic Agents; Automatism; Brain; Chlorpromazine; Clozapine; Electroencephalography; Haloperidol; Humans; Perphenazine; Schizophrenia; Trifluoperazine | 1982 |
Neurochemical effects of buspirone, a novel psychotropic drug, on the central cholinergic system.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Apomorphine; Brain Chemistry; Buspirone; Clozapine; Corpus Striatum; Female; Haloperidol; Male; Parasympathetic Nervous System; Postural Balance; Pyrimidines; Rats; Time Factors | 1982 |
Effects of various catecholamine receptor antagonists, muscle relaxation and physical hindrance on shuttlebox self-stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clozapine; Haloperidol; Male; Methocarbamol; Metoclopramide; Muscle Relaxants, Central; Prazosin; Rats; Rats, Inbred F344; Reaction Time; Receptors, Dopamine; Self Stimulation | 1982 |
The contrasting effects of neuroleptics on transmitter release from the nucleus accumbens and corpus striatum.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Atropine; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Female; Haloperidol; Neurotransmitter Agents; Nucleus Accumbens; Potassium; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Dopamine; Septal Nuclei; Thioridazine | 1982 |
Notes on buspirone's mechanisms of action.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain Chemistry; Buspirone; Catalepsy; Chemical Phenomena; Chemistry; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Humans; Pyrimidines; Receptors, Cell Surface; Receptors, GABA-A; Stereotyped Behavior | 1982 |
Inhibition of leu-enkephalin binding by neuroleptics.
Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Leucine; Haloperidol; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
[Effects of neuroleptics on liver function, the hematopoietic system, blood pressure and temperature regulation. Comparison of clozapine, perazine and haloperidol by evaluating medical records].
Topics: Adult; Aged; Antipsychotic Agents; Blood Pressure; Body Temperature Regulation; Clozapine; Dibenzazepines; Female; Haloperidol; Hematopoiesis; Humans; Leukocytes; Liver Function Tests; Male; Medical Records; Middle Aged; Perazine | 1983 |
Comparison of the effects of antipsychotic drugs on the schedule-controlled behavior of squirrel monkeys and pigeons.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Columbidae; Conditioning, Psychological; Haloperidol; Male; Molindone; Promazine; Saimiri; Species Specificity; Thiothixene | 1983 |
Buspirone: a potential atypical neuroleptic.
Topics: Animals; Antipsychotic Agents; Buspirone; Clozapine; Dopamine; Dose-Response Relationship, Drug; Haloperidol; Male; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Sulpiride; Time Factors | 1983 |
Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; gamma-Aminobutyric Acid; Haloperidol; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Synaptic Transmission; Tegmentum Mesencephali | 1983 |
Regional selectivity of neuroleptic drugs: an argument for site specificity.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Fluphenazine; Haloperidol; Limbic System; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thioridazine | 1983 |
Cataleptogenic potency of the antipsychotic drugs is inversely correlated with neuronal activity in the amygdaloid complex of the rat.
Topics: Action Potentials; Amygdala; Animals; Antipsychotic Agents; Catalepsy; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Neurons; Pimozide; Rats; Rats, Inbred Strains; Thioridazine | 1983 |
Cholecystokinin octapeptide levels in rat brain are changed after subchronic neuroleptic treatment.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Chlorpromazine; Cholecystokinin; Clozapine; Haloperidol; Male; Rats; Rats, Inbred Strains; Sincalide; Tetragastrin | 1983 |
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidine; Clozapine; Depressive Disorder; Desipramine; Dibenzazepines; Haloperidol; Humans; Male; Metoclopramide; Phentolamine; Prazosin; Propranolol; Rats; Sulpiride | 1984 |
A comparison of the effects of acute and one year's continuous neuroleptic treatment on the release of [3H]glutamate and [3H]acetylcholine from rat striatal slices.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Calcium; Clozapine; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; Haloperidol; In Vitro Techniques; Male; Potassium; Rats; Rats, Inbred Strains; Sulpiride; Trifluoperazine | 1984 |
Effects of antipsychotic drugs on the long-term effects of amphetamine on nigro-striatal dopamine neurons in iprindole-treated rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Brain; Clozapine; Corpus Striatum; Dextroamphetamine; Dopamine; Haloperidol; Indoles; Iprindole; Male; Methyltyrosines; Neurons; Rats; Rats, Inbred Strains; Sulpiride | 1984 |
[Changes in the number of benzodiazepine receptors in different parts of the brain of rats after neuroleptic withdrawal].
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Flunitrazepam; Haloperidol; Humans; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substance Withdrawal Syndrome; Sulpiride; Time Factors | 1984 |
Effects of antipsychotic drugs on brain-stimulation detection: preliminary observations.
Topics: Animals; Antipsychotic Agents; Brain; Brain Mapping; Clozapine; Electric Stimulation; Haloperidol; Hypothalamus; Male; Mesencephalon; Rats; Telencephalon | 1984 |
Acute and subchronic effects of neuroleptics on quantitative measures of discriminative motor control in rats.
Topics: Animals; Antipsychotic Agents; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Haloperidol; Male; Psychomotor Performance; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1984 |
Effects of several neuroleptic compounds on the blastogenic response of spleen cells from mice.
Topics: Animals; Antipsychotic Agents; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Chlorpromazine; Clozapine; Dextran Sulfate; Dextrans; Dibenzothiazepines; Haloperidol; Lipopolysaccharides; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Spleen; T-Lymphocytes | 1982 |
Neuroleptics increase striatal catecholamine metabolites but not ascorbic acid in dialyzed perfusate.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Ascorbic Acid; Catecholamines; Catheterization; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Kinetics; Male; Perfusion; Rats; Rats, Inbred Strains | 1984 |
The effects of SCH 23390, YM 09151-2, (+)- and (-)-3-PPP and some classical neuroleptics on D-1 and D-2 receptors in rat neostriatum in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Antipsychotic Agents; Aporphines; Benzamides; Benzazepines; Caudate Nucleus; Chlorpromazine; Clozapine; Flupenthixol; Haloperidol; In Vitro Techniques; Male; Piperidines; Potassium; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1984 |
Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain.
Topics: Animals; Clozapine; Dibenzazepines; Dibenzoxazepines; Haloperidol; Loxapine; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sulpiride; Time Factors | 1984 |
Differential effects of haloperidol and clozapine on attention.
Topics: Animals; Apomorphine; Attention; Clozapine; Dibenzazepines; Female; Gerbillinae; Haloperidol; Male; Norepinephrine; Time Factors | 1984 |
Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats.
Topics: Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Sulpiride | 1984 |
Drug-induced modulation of locomotor hyperactivity induced by picrotoxin in nucleus accumbens.
Topics: Animals; Apomorphine; Carbachol; Clozapine; Diazepam; Haloperidol; Lisuride; Lysergic Acid Diethylamide; Male; Motor Activity; Nucleus Accumbens; Picrotoxin; Rats; Rats, Inbred Strains; Reserpine; Septal Nuclei; Sulpiride | 1984 |
Effects of catecholamine agonist and antagonist drugs on acute stomach ulceration induced by medial hypothalamic lesions in rats.
Topics: Amphetamine; Animals; Catecholamines; Chlorpromazine; Clozapine; Desipramine; Haloperidol; Hypothalamus, Middle; Isoproterenol; Male; Pargyline; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Stomach Ulcer | 1983 |
LSD-potentiated apomorphine hypermotility: a model for differentiating antipsychotic drugs.
Topics: Animals; Apomorphine; Chlorpromazine; Clozapine; Disease Models, Animal; Drug Antagonism; Haloperidol; Humans; Hyperkinesis; Lysergic Acid Diethylamide; Male; Motor Activity; Rats; Rats, Inbred Strains; Sulpiride | 1983 |
Possible dopaminergic involvement in biting compulsion induced by large doses of clonidine.
Topics: Aggression; Amphetamine; Animals; Clonidine; Clozapine; Dopamine; Drug Interactions; Female; Haloperidol; Humans; Male; Mice; Phenoxybenzamine; Scopolamine | 1983 |
Clozapine--a serotonin antagonist?
Topics: Animals; Apomorphine; Clonidine; Clozapine; Dibenzazepines; Drug Interactions; Haloperidol; Lysergic Acid Diethylamide; Male; Microinjections; Motor Activity; Nucleus Accumbens; Phentolamine; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin Antagonists | 1984 |
Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol.
Topics: Acetylcholine; Animals; Apomorphine; Behavior, Animal; Clozapine; Corpus Striatum; Dibenzazepines; Haloperidol; Humans; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior | 1982 |
Differential sensitivity to amphetamine following long-term treatment with clozapine or haloperidol.
Topics: Amphetamine; Animals; Behavior, Animal; Clozapine; Dibenzazepines; Drug Tolerance; Haloperidol; Humans; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior | 1982 |
Dopaminergic effects of buspirone, a novel anxiolytic agent.
Topics: Animals; Buspirone; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Haloperidol; In Vitro Techniques; Pyrimidines; Rats; Receptors, Dopamine | 1983 |
Behavioral effects of clozapine: comparison with thioridazine, chlorpromazine, haloperidol and chlordiazepoxide in squirrel monkeys.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Clozapine; Conditioning, Operant; Dibenzazepines; Electroshock; Food; Haloperidol; Male; Reinforcement Schedule; Saimiri; Thioridazine; Tranquilizing Agents | 1983 |
Effects of clozapine, haloperidol and thiothixene on schedule-controlled responding and schedule-induced eating and drinking of rabbits.
Topics: Animals; Clozapine; Conditioning, Operant; Dibenzazepines; Dose-Response Relationship, Drug; Drinking; Eating; Female; Haloperidol; Rabbits; Reinforcement Schedule; Thiothixene | 1982 |
The pharmacological evaluation of pergolide mesylate as a potential anti-parkinson agent.
Topics: alpha-Methyltyrosine; Animals; Antiparkinson Agents; Apomorphine; Clozapine; Drug Interactions; Emetics; Ergolines; Guinea Pigs; Haloperidol; Humans; Hydroxydopamines; Male; Methyltyrosines; Pergolide; Rats; Stereotyped Behavior | 1980 |
[Possible discrepancy between behavioral adequacy and motor automatisms in cats with phenamine-induced stereotypy].
Topics: Amphetamine; Animals; Cats; Clozapine; Dibenzazepines; Female; Haloperidol; Humans; Male; Metoclopramide; Stereotyped Behavior | 1981 |
Regional blockade by neuroleptic drugs of in vivo 3H-spiperone binding in the rat brain. Relation to blockade of apomorphine induced hyperactivity and stereotypies.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Butyrophenones; Chlorpromazine; Clozapine; Haloperidol; Humans; Hyperkinesis; Kinetics; Organ Specificity; Rats; Receptors, Dopamine; Receptors, Drug; Spiperone; Stereotyped Behavior; Sulpiride; Thioridazine | 1981 |
Time course of chronic haloperidol and clozapine upon operant rate and duration.
Topics: Animals; Clozapine; Conditioning, Operant; Dibenzazepines; Haloperidol; Male; Rats; Reinforcement Schedule; Time Factors | 1981 |
Clozapine inhibition of metenkephalin binding to synaptosome-enriched fractions of rat whole brain and hippocampus.
Topics: Animals; Brain; Chlorpromazine; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Haloperidol; Hippocampus; Prochlorperazine; Rats; Synaptosomes | 1981 |
Behavioural effects of acute and chronic beta-phenylethylamine administration in the rat: evidence for the involvement of 5-hydroxytryptamine.
Topics: Animals; Behavior, Animal; Clozapine; Crowding; Haloperidol; Male; Methysergide; Mianserin; Phenethylamines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin | 1981 |
[Cloxazepine: neuropharmacological studies].
Topics: Animals; Behavior, Animal; Chlorpromazine; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Haloperidol; Lethal Dose 50; Mice; Mice, Inbred Strains; Motor Activity; Nervous System; Rats | 1981 |
Differential effects of certain dopaminergic drugs on the striatal concentration of dopamine metabolites, with special reference to 3-methoxytramine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Male; Nomifensine; Phenylacetates; Piribedil; Quipazine; Rats | 1981 |
Chronic blockade of dopamine receptors by antischizophrenic drugs enhances GABA binding in substantia nigra.
Topics: Animals; Binding Sites; Chlorpromazine; Clozapine; Corpus Striatum; Dibenzazepines; gamma-Aminobutyric Acid; Haloperidol; Male; Rats; Receptors, Dopamine; Substantia Nigra | 1980 |
Amphetamine-induced increases in dopaminergic single cell firing rate after haloperidol pretreatment. Correlation with extrapyramidal side effects.
Topics: Animals; Apomorphine; Brain; Clozapine; Dextroamphetamine; Dopamine; Drug Interactions; Extrapyramidal Tracts; Haloperidol; Male; Metoclopramide; Neurons; Rats; Substantia Nigra; Thioridazine | 1980 |
Long-term effects of haloperidol, Clozapine, and methadone on rat striatal cholinergic and dopaminergic dynamics.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Drug Tolerance; Haloperidol; Homovanillic Acid; Male; Methadone; Neurons; Parasympathetic Nervous System; Rats | 1980 |
Behavioral and biochemical correlates after haloperidol and clozapine long-term treatment.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain Chemistry; Clozapine; Corpus Striatum; Dibenzazepines; Dopamine; Haloperidol; Homovanillic Acid; Male; Rats; Time Factors | 1980 |
Neostriatal and mesolimbic neurons: dose-dependent effects of clozapine.
Topics: Animals; Brain; Caudate Nucleus; Clozapine; Dibenzazepines; Haloperidol; Limbic System; Male; Neurons; Nucleus Accumbens; Putamen; Rats; Time Factors | 1980 |
Repeated treatment with haloperidol and clozapine exerts differential effects on dye coupling between neurons in subregions of striatum and nucleus accumbens.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine Antagonists; Electrophysiology; Fluorescent Dyes; Haloperidol; Isoquinolines; Male; Neurons; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1995 |
Antipsychotic drugs induce Fos protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Clozapine; Haloperidol; Immunohistochemistry; Male; Muscarinic Antagonists; Prazosin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Ritanserin; Scopolamine; Serotonin Antagonists; Sulpiride; Thalamic Nuclei | 1995 |
The effect of clozapine on Fos protein immunoreactivity in the rat forebrain is not mimicked by the addition of alpha 1-adrenergic or 5HT2 receptor blockade to haloperidol.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Clozapine; Haloperidol; Male; Nucleus Accumbens; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 1995 |
Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dextroamphetamine; Dose-Response Relationship, Drug; Fluphenazine; Haloperidol; Imidazoles; Indoles; Locomotion; Male; Motor Activity; Prazosin; Rats; Rats, Wistar; Ritanserin | 1995 |
Control of tachykinin-evoked acetylcholine release from rat striatal slices by dopaminergic neurons.
Topics: Acetylcholine; Animals; Benzazepines; Clozapine; Dopamine; Dopamine Agents; Haloperidol; In Vitro Techniques; Male; Neostriatum; Neurons; Oxidopamine; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-3; Substance P; Tachykinins | 1993 |
Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography.
Topics: Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Behavior, Animal; Clozapine; Guinea Pigs; Haloperidol; In Vitro Techniques; Iodine Radioisotopes; Isoxazoles; Male; Mescaline; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Serotonin; Risperidone; Stereotyped Behavior | 1993 |
Pharmacological action of zotepine and other antipsychotics on central 5-hydroxytryptamine receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Body Temperature; Clozapine; Dibenzothiepins; Exploratory Behavior; Haloperidol; Isoxazoles; Male; Mice; Motor Activity; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells.
Topics: Amiloride; Animals; Arachidonic Acid; Base Sequence; Butaclamol; CHO Cells; Cloning, Molecular; Clozapine; Cricetinae; Cyclic AMP; DNA; Dopamine; Dopamine Antagonists; Ergolines; Genes, Synthetic; Haloperidol; Humans; Kinetics; Molecular Sequence Data; Pertussis Toxin; Protein Kinase C; Quinpirole; Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Signal Transduction; Sodium-Hydrogen Exchangers; Transfection; Virulence Factors, Bordetella | 1994 |
Serotonin2 receptor-mediated excitation of interneurons in piriform cortex: antagonism by atypical antipsychotic drugs.
Topics: Action Potentials; Animals; Antipsychotic Agents; Bicuculline; Cerebral Cortex; Chlorpromazine; Clozapine; Electrophysiology; gamma-Aminobutyric Acid; Haloperidol; In Vitro Techniques; Interneurons; Isoxazoles; Male; Membrane Potentials; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Risperidone; Serotonin Antagonists | 1994 |
Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.
Topics: Animals; Antipsychotic Agents; Brain; Clone Cells; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Guinea Pigs; Haloperidol; Humans; Isoxazoles; Paliperidone Palmitate; Piperidines; Pyrimidines; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Serotonin Antagonists | 1994 |
Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: role of 5HT2 receptors.
Topics: Animals; Antipsychotic Agents; Autoradiography; Clozapine; Haloperidol; In Vitro Techniques; Isoxazoles; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Neurotransmitter; Receptors, Serotonin; Risperidone | 1993 |
Effects of typical and atypical antipsychotic drugs on response decrement patterns in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Conditioning, Operant; Dose-Response Relationship, Drug; Haloperidol; Isoxazoles; Male; Piperidines; Rats; Rats, Wistar; Remoxipride; Risperidone; Serotonin Antagonists; Sulpiride | 1995 |
Interaction of clozapine with the histamine H3 receptor in rat brain.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Clozapine; Haloperidol; Histamine Antagonists; Histamine Release; Imidazoles; Isothiuronium; Methylhistamines; Piperidines; Rats; Receptors, Histamine H3 | 1995 |
Olanzapine, an atypical antipsychotic, increases rates of punished responding in pigeons.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Clozapine; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Haloperidol; Isoxazoles; Male; Olanzapine; Piperidines; Pirenzepine; Punishment; Risperidone | 1995 |
The pharmacological profile of iloperidone, a novel atypical antipsychotic agent.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Basal Ganglia Diseases; Behavior, Animal; Clozapine; Dopamine Antagonists; Haloperidol; Isoxazoles; Male; Mice; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Risperidone; Saimiri; Serotonin Antagonists | 1995 |
Genetic variation of the 5-HT2A receptor and response to clozapine.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Humans; Polymorphism, Genetic; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Schizophrenia | 1995 |
Clozapine in tardive Tourette syndrome.
Topics: Adult; Antipsychotic Agents; Clozapine; Dyskinesia, Drug-Induced; Haloperidol; Humans; Injections, Intramuscular; Male; Neurologic Examination; Schizophrenia; Schizophrenic Psychology; Social Behavior; Substance Withdrawal Syndrome; Tourette Syndrome | 1995 |
Plasma clozapine levels and clinical benefit.
Topics: Adolescent; Clinical Trials as Topic; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Haloperidol; Humans; Psychiatric Status Rating Scales; ROC Curve; Schizophrenia; Schizophrenic Psychology | 1995 |
Differential effects of dopamine antagonists on evoked dopamine release from slices of striatum and nucleus accumbens in rats.
Topics: Animals; Binding, Competitive; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Electric Stimulation; Haloperidol; Male; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Sulpiride | 1995 |
Clozapine decreases serotonin extracellular levels in the nucleus accumbens by a dopamine receptor-independent mechanism.
Topics: Animals; Clozapine; Dopamine; Dopamine Agonists; Ergolines; Haloperidol; Microdialysis; Nucleus Accumbens; Quinpirole; Raclopride; Rats; Receptors, Dopamine; Salicylamides; Serotonin; Time Factors | 1995 |
Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats.
Topics: Aggression; Animals; Apomorphine; Benzodiazepinones; Brain Chemistry; Clozapine; Devazepide; Dizocilpine Maleate; Haloperidol; Male; Phenylurea Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cholecystokinin; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate | 1995 |
Glutamate decarboxylase messenger RNA in rat pallidum: comparison of the effects of haloperidol, clozapine and combined haloperidol-scopolamine treatments.
Topics: Animals; Behavior, Animal; Catalepsy; Clozapine; Drug Interactions; Gene Expression Regulation, Enzymologic; Globus Pallidus; Glutamate Decarboxylase; Haloperidol; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Scopolamine | 1995 |
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants.
Topics: Animals; Benzamides; Cell Line; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; Dinoprostone; Dopamine; Haloperidol; HeLa Cells; Humans; Raclopride; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone; Transfection | 1995 |
Different effects of subchronic clozapine and haloperidol on dye-coupling between neurons in the rat striatal complex.
Topics: Animals; Clozapine; Coloring Agents; Corpus Striatum; Gap Junctions; Haloperidol; Isoquinolines; Neurons; Nucleus Accumbens; Putamen; Rats; Rats, Inbred Strains | 1995 |
Effects of atypical antipsychotic agents on social behavior in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior | 1993 |
[A study on the pharmacological properties of atypical antipsychotic drugs: in vivo dopamine and serotonin receptor occupancy by atypical antipsychotic drugs in the rat brain].
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Chlorpromazine; Clozapine; Dibenzothiepins; Flupenthixol; Haloperidol; In Vitro Techniques; Isoxazoles; Male; Piperidines; Pyrimidinones; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Risperidone | 1993 |
Pharmacological effects of zotepine and other antipsychotics on the central 5-HT2 receptors.
Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiepins; Haloperidol; Isoxazoles; Male; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Risperidone | 1993 |
The atypical antipsychotic, remoxipride, blocks phencyclidine-induced disruption of prepulse inhibition in the rat.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Phencyclidine; Raclopride; Rats; Rats, Sprague-Dawley; Reflex, Startle; Remoxipride; Salicylamides | 1994 |
Differential Fos-protein induction in rat forebrain regions after acute and long-term haloperidol and clozapine treatment.
Topics: Animals; Body Weight; Catalepsy; Clozapine; Haloperidol; Immunohistochemistry; Male; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Weight Gain | 1995 |
D1 and D2 dopamine receptors differentially increase Fos-like immunoreactivity in accumbal projections to the ventral pallidum and midbrain.
Topics: Animals; Clozapine; Haloperidol; Immunohistochemistry; Male; Mesencephalon; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1995 |
[Drug treatment of schizophrenic psychoses in puerperium].
Topics: Adult; Antipsychotic Agents; Bromocriptine; Chronic Disease; Clozapine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Haloperidol; Humans; Lactation; Psychotic Disorders; Puerperal Disorders; Schizophrenia; Schizophrenic Psychology | 1994 |
Time course of dopamine1,2 and serotonin2 receptor binding of antipsychotics in vivo.
Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzazepines; Haloperidol; Ligands; Male; Neostriatum; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin | 1994 |
Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Base Sequence; Brain Chemistry; Citalopram; Clozapine; Gene Expression Regulation; Haloperidol; Male; Mianserin; Molecular Sequence Data; Nerve Tissue Proteins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Schizophrenia; Sulpiride | 1994 |
Effects of zotepine, haloperidol and clozapine on MK-801-induced stereotypy and locomotion in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiepins; Dizocilpine Maleate; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Rats; Rats, Wistar; Stereotyped Behavior | 1994 |
D2-dopamine receptor occupancy differs between patients with and without extrapyramidal side effects.
Topics: Adult; Basal Ganglia Diseases; Clozapine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Extrapyramidal Tracts; Female; Haloperidol; Humans; Male; Middle Aged; Neurologic Examination; Receptors, Dopamine D2; Schizophrenia; Schizophrenic Psychology; Tomography, Emission-Computed, Single-Photon | 1994 |
Striatal D2-dopamine receptor occupancy during treatment with typical and atypical neuroleptics.
Topics: Adult; Clozapine; Corpus Striatum; Dose-Response Relationship, Drug; Haloperidol; Humans; Middle Aged; Receptors, Dopamine D2; Schizophrenia; Tomography, Emission-Computed, Single-Photon | 1994 |
Chronic haloperidol, but not clozapine, produces altered oral movements and increased extracellular glutamate in rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Behavior, Animal; Clozapine; Corpus Striatum; Electric Stimulation; Female; Fourier Analysis; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Image Processing, Computer-Assisted; Microdialysis; Motor Activity; Rats; Rats, Sprague-Dawley | 1994 |
Atypical antipsychotics, clozapine and sulpiride do not antagonise amphetamine-induced stereotyped locomotion.
Topics: Amphetamine; Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Motor Activity; Rats; Rats, Wistar; Stereotyped Behavior; Sulpiride | 1994 |
Regulation of serotonin 5-HT2C receptors in the rat choroid plexus after acute clozapine treatment.
Topics: Amphetamines; Animals; Antiparkinson Agents; Autoradiography; Cerebral Cortex; Choroid Plexus; Clozapine; Ergolines; Haloperidol; Image Processing, Computer-Assisted; Injections, Subcutaneous; Male; Neostriatum; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Receptor Agonists | 1994 |
Repeated treatment with ascorbate or haloperidol, but not clozapine, elevates extracellular ascorbate in the neostriatum of freely moving rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amphetamine; Animals; Ascorbic Acid; Clozapine; Extracellular Space; Haloperidol; Male; Microelectrodes; Motor Activity; Neostriatum; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1994 |
Unlike haloperidol, clozapine slows and dampens rats' forelimb force oscillations and decreases force output in a press-while-licking behavioral task.
Topics: Animals; Clozapine; Conditioning, Operant; Dose-Response Relationship, Drug; Forelimb; Haloperidol; Male; Movement; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Water Deprivation | 1994 |
Clozapine's functional mesolimbic selectivity is not duplicated by the addition of anticholinergic action to haloperidol: a brain stimulation study in the rat.
Topics: Animals; Brain; Cholinergic Antagonists; Clozapine; Dopamine; Electric Stimulation; Haloperidol; Limbic System; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Reward; Trihexyphenidyl; Up-Regulation | 1993 |
The effects of haloperidol and clozapine on the disruption of sensorimotor gating induced by the noncompetitive glutamate antagonist MK-801.
Topics: Acoustic Stimulation; Animals; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Reflex, Startle | 1993 |
Seroquel: electrophysiological profile of a potential atypical antipsychotic.
Topics: Action Potentials; Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Brain; Clozapine; Dibenzothiazepines; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Male; Microelectrodes; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1993 |
Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Benzazepines; Cerebral Cortex; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Gene Expression Regulation; Haloperidol; Humans; Limbic System; Male; Mesencephalon; Mianserin; Models, Neurological; Oxidopamine; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Salicylamides; Schizophrenia; Serotonin; Substantia Nigra | 1995 |
Multiunit activity from the A9 and A10 areas in rats following chronic treatment with different neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Electrophysiology; Extracellular Space; Haloperidol; Male; Neurons; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiazines; Ventral Tegmental Area | 1994 |
Anti-glutamatergic effects of clozapine.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Haloperidol; Humans; Membrane Potentials; Rats; Vibrissae | 1993 |
The role of serotonin receptor subtypes in the behavioural effects of neuroleptic drugs. A paw test study in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Behavior, Animal; Clozapine; Haloperidol; Ketanserin; Male; Rats; Rats, Wistar; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Characterization of the functional activity of dopamine ligands at human recombinant dopamine D4 receptors.
Topics: Animals; Cell Line; Clozapine; DNA; Dopamine; Dopamine Agents; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Ligands; Moths; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Salicylamides; Spiperone; Sulfur Radioisotopes; Tritium | 1994 |
Comparison of short-term administration of sertindole, clozapine and haloperidol on the inactivation of midbrain dopamine neurons in the rat.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Imidazoles; Indoles; Male; Rats; Rats, Wistar; Substantia Nigra; Ventral Tegmental Area | 1994 |
Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations.
Topics: Animals; Antipsychotic Agents; Caudate Nucleus; Clozapine; Dopamine; Extracellular Space; Glutamates; Glutamic Acid; Haloperidol; Male; Microdialysis; Nucleus Accumbens; Osmolar Concentration; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Differential effects of antipsychotic and psychotomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions.
Topics: Animals; Antipsychotic Agents; Caudate Nucleus; Clozapine; Cocaine; Corpus Striatum; Dopamine; Dopamine D2 Receptor Antagonists; Extrapyramidal Tracts; Globus Pallidus; Hallucinogens; Haloperidol; Limbic System; Male; Methamphetamine; Neurotensin; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1994 |
3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple t
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine; Frontal Lobe; Haloperidol; Kinetics; Male; Methylation; Models, Biological; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 1994 |
Compliance with antipsychotic drug treatment: influence of side effects.
Topics: Adult; Age Factors; Akathisia, Drug-Induced; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Male; Patient Compliance; Physician-Patient Relations; Social Environment; Socioeconomic Factors | 1994 |
Subchronic treatment with haloperidol and clozapine in rats with neonatal excitotoxic hippocampal damage.
Topics: Animals; Animals, Newborn; Apomorphine; Clozapine; Female; Haloperidol; Hippocampus; Ibotenic Acid; Motor Activity; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Stereotyped Behavior; Substance Withdrawal Syndrome | 1994 |
Brain region effects of clozapine on amino acid and monoamine transmission.
Topics: Amino Acids; Animals; Brain Chemistry; Clozapine; Dopamine; Extracellular Space; Frontal Lobe; gamma-Aminobutyric Acid; Glutamates; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Serotonin; Substantia Nigra | 1994 |
Differential effects of locally administered clozapine and haloperidol on dopamine efflux in the rat prefrontal cortex and caudate-putamen.
Topics: Animals; Caudate Nucleus; Clozapine; Dopamine; Haloperidol; Male; Prefrontal Cortex; Putamen; Rats; Rats, Sprague-Dawley | 1994 |
Pharmacological studies with two new ergoline derivatives, the potential antipsychotics LEK-8829 and LEK-8841.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Antipsychotic Agents; Benzazepines; Blood Pressure; Catalepsy; Clozapine; Dose-Response Relationship, Drug; Ergolines; Haloperidol; Lysergic Acid; Male; Mice; Muscarinic Antagonists; Rats; Serotonin Antagonists; Spiperone | 1994 |
Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos mRNA in rat neostriatal subregions.
Topics: Animals; Clozapine; Corpus Striatum; Genes, fos; Haloperidol; Male; Neurotensin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger | 1994 |
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine.
Topics: Amphetamines; Animals; Autoradiography; Choroid Plexus; Clozapine; Ergolines; Haloperidol; Hydrolysis; Image Processing, Computer-Assisted; In Vitro Techniques; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Second Messenger Systems; Serotonin Receptor Agonists | 1994 |
Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja.
Topics: Animals; Caudate Nucleus; Clozapine; DNA-Binding Proteins; Dyskinesia, Drug-Induced; Early Growth Response Protein 1; Gene Expression Regulation; Genes, Immediate-Early; Haloperidol; Immediate-Early Proteins; Male; Neostriatum; Nerve Tissue Proteins; Nucleus Accumbens; Olfactory Pathways; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Putamen; Rats; Rats, Wistar; Septum Pellucidum; Transcription Factors | 1994 |
More on obsessive-compulsive symptoms and clozapine.
Topics: Adult; Clozapine; Haloperidol; Humans; Male; Obsessive-Compulsive Disorder; Schizophrenia; Schizophrenic Psychology | 1994 |
Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Biogenic Monoamines; Clozapine; Dogs; Dopamine D2 Receptor Antagonists; Guinea Pigs; Haloperidol; Macaca fascicularis; Male; Mice; Mice, Inbred Strains; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Prosencephalon; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists; Spiperone; Tritium | 1993 |
Clozapine inhibits limbic system kindling: implications for antipsychotic action.
Topics: Acetylcholine; Amygdala; Animals; Antipsychotic Agents; Clozapine; Dopamine; Drug Interactions; Electroencephalography; Haloperidol; Hippocampus; Kindling, Neurologic; Limbic System; Male; Parasympatholytics; Pilocarpine; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome | 1993 |
Irreversible blockade of D2 dopamine receptors by fluphenazine-N-mustard increases glutamic acid decarboxylase mRNA in rat striatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Base Sequence; Blotting, Northern; Clozapine; Corpus Striatum; Depression, Chemical; Dopamine D2 Receptor Antagonists; Fluphenazine; Glutamate Decarboxylase; Haloperidol; In Vitro Techniques; Male; Molecular Sequence Data; Oligodeoxyribonucleotides; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA Probes; RNA, Messenger | 1993 |
Neuroleptic medications inhibit complex I of the electron transport chain.
Topics: Adult; Animals; Antipsychotic Agents; Blood Platelets; Brain; Chlorpromazine; Clozapine; Dose-Response Relationship, Drug; Electron Transport; Electron Transport Complex III; Female; Haloperidol; Humans; Kinetics; Male; Mitochondria; NAD(P)H Dehydrogenase (Quinone); Rats; Thiothixene | 1993 |
Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats.
Topics: Animals; Aspartic Acid; Clozapine; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Haloperidol; Male; Rats; Rats, Sprague-Dawley | 1993 |
Locomotor stereotypy is produced by methylphenidate and amfonelic acid and reduced by haloperidol but not clozapine or thioridazine.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Methylphenidate; Motor Activity; Nalidixic Acid; Naphthyridines; Rats; Rats, Wistar; Stereotyped Behavior; Thioridazine | 1993 |
Effects of four antipsychotics on punished responding in rats.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chlordiazepoxide; Chlorpromazine; Clozapine; Conflict, Psychological; Drug Evaluation, Preclinical; Haloperidol; Male; Punishment; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Structure-Activity Relationship; Thioridazine | 1993 |
Effect of scopolamine on the efflux of dopamine and its metabolites after clozapine, haloperidol or thioridazine.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Biological Transport; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Scopolamine; Thioridazine | 1994 |
[Clozapine and priapism: an association to consider].
Topics: Adult; Clozapine; Drug Therapy, Combination; Haloperidol; Humans; Libido; Male; Penile Erection; Priapism; Schizophrenia; Schizophrenic Psychology | 1994 |
Human brain receptors, IV. Human in vivo receptor imaging.
Topics: Adult; Basal Ganglia; Carbon Radioisotopes; Clozapine; Corpus Striatum; GTP-Binding Proteins; Haloperidol; Humans; Male; Receptors, Dopamine D2; Tomography, Emission-Computed | 1994 |
A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex.
Topics: Analysis of Variance; Animals; Autoradiography; Benzamides; Benzazepines; Cerebral Cortex; Clozapine; Haloperidol; Iodine Radioisotopes; Kinetics; Macaca mulatta; Motor Cortex; Prefrontal Cortex; Pyrrolidines; Receptors, Dopamine D1; Receptors, Dopamine D2; Remoxipride; Schizophrenia; Somatosensory Cortex; Temporal Lobe; Tritium; Visual Cortex | 1994 |
The effects of haloperidol and clozapine on PCP- and amphetamine-induced suppression of social behavior in the rat.
Topics: Aggression; Amphetamine; Animals; Clozapine; Haloperidol; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Social Behavior | 1994 |
The atypical neuroleptic, clozapine, exerts antidystonic activity in a mutant hamster model. Comparison with haloperidol.
Topics: Animals; Clozapine; Cricetinae; Disease Models, Animal; Dystonia; Female; Haloperidol; Male; Mesocricetus; Mutation | 1993 |
Acute dystonia due to clozapine.
Topics: Acute Disease; Biperiden; Clozapine; Dystonia; Haloperidol; Humans; Male; Middle Aged; Schizophrenia | 1994 |
3H-spiroperidol binding to peripheral mononuclear cells in schizophrenic and healthy subjects.
Topics: Adult; Binding, Competitive; Clozapine; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Radioligand Assay; Receptors, Dopamine; Schizophrenia; Schizophrenic Psychology; Spiperone | 1993 |
Chronic clozapine treatment decreases 5-hydroxytryptamine1C receptor density in the rat choroid plexus: comparison with haloperidol.
Topics: Animals; Choroid Plexus; Clozapine; Down-Regulation; Haloperidol; In Vitro Techniques; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin | 1993 |
Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigra.
Topics: Animals; Base Sequence; Clozapine; Haloperidol; In Situ Hybridization; Male; Molecular Sequence Data; Oligonucleotide Probes; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Receptors, Neurotransmitter; RNA, Messenger; Substantia Nigra | 1993 |
Frontal cortex lesions modify the cataleptogenic properties of haloperidol but not of clozapine.
Topics: Animals; Catalepsy; Cerebral Cortex; Clozapine; Corpus Striatum; Dopamine; Frontal Lobe; Haloperidol; Male; Rats | 1993 |
Time course of dopamine-D2 and serotonin-5-HT2 receptor occupancy rates by haloperidol and clozapine in vivo.
Topics: Animals; Brain; Clozapine; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Time Factors | 1993 |
Differentiation of haloperidol and clozapine using a complex operant schedule in the dog.
Topics: Animals; Clozapine; Conditioning, Operant; Dogs; Haloperidol; Male; Motor Activity; Reinforcement Schedule; Salivation; Substance Withdrawal Syndrome | 1993 |
Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia.
Topics: Animals; Apomorphine; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Habituation, Psychophysiologic; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenic Psychology | 1993 |
Haloperidol and clozapine increase intraneuronal dopamine metabolism, but not gamma-butyrolactone-resistant dopamine release.
Topics: 3,4-Dihydroxyphenylacetic Acid; 4-Butyrolactone; Animals; Brain Chemistry; Cerebral Cortex; Clozapine; Dopamine; Dopamine Antagonists; Haloperidol; Homovanillic Acid; Male; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Dopamine | 1993 |
[Effect of D1 and D2 dopamine receptor antagonists on acupuncture analgesia].
Topics: Acupuncture Analgesia; Animals; Benzazepines; Clozapine; Domperidone; Dopamine D2 Receptor Antagonists; Electroacupuncture; Female; Haloperidol; Male; Pain Threshold; Rabbits; Receptors, Dopamine D1; Sulpiride | 1993 |
Differentiation between MK-801- and apomorphine-induced stereotyped behaviors in mice.
Topics: Analysis of Variance; Animals; Apomorphine; Clozapine; Dizocilpine Maleate; Haloperidol; Male; Mice; Stereotyped Behavior; Time Factors | 1993 |
Measurement of an explosive behavior in the mouse, induced by MK-801, a PCP analogue.
Topics: Analysis of Variance; Animals; Behavior, Animal; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Receptors, Phencyclidine; Time Factors | 1993 |
Haloperidol and loxapine but not clozapine increase synaptic responses in the hippocampus.
Topics: Animals; Clozapine; Haloperidol; Hippocampus; In Vitro Techniques; Loxapine; Rats; Rats, Wistar; Synapses; Tranquilizing Agents | 1993 |
Effects of antipsychotics on cognitive behaviour in rats using the delayed non-match to position paradigm.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Clozapine; Cognition; Dopamine Antagonists; Haloperidol; Male; Memory; Raclopride; Rats; Rats, Wistar; Salicylamides; Time Factors | 1995 |
The thalamus as a site of action of antipsychotic drugs.
Topics: Animals; Clozapine; Gene Expression Regulation; Genes, fos; Haloperidol; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Thalamic Nuclei; Thalamus | 1996 |
Deriving the therapeutic concentrations for clozapine and haloperidol: the apparent dissociation constant of a neuroleptic at the dopamine D2 or D4 receptor varies with the affinity of the competing radioligand.
Topics: Animals; Binding, Competitive; Caudate Nucleus; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Humans; Pituitary Gland; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Salicylamides; Swine | 1995 |
[Quantitative autoradiographic analysis of the binding of mosapramine to dopamine D3-receptors].
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzazepines; Brain; Clozapine; Haloperidol; In Vitro Techniques; Ligands; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3 | 1995 |
Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys.
Topics: Analysis of Variance; Animals; Benzazepines; Carbolines; Clozapine; Dopamine; Dopamine Antagonists; Female; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Haloperidol; Macaca mulatta; Male; Maze Learning; Memory; Motor Activity; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Space Perception; Stress, Psychological | 1996 |
Effects of haloperidol, clozapine and citalopram on messenger RNA levels of chromogranins A and B and secretogranin II in various regions of rat brain.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Brain; Chromogranins; Citalopram; Clozapine; Haloperidol; Male; Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tissue Distribution | 1995 |
Comparative dopaminergic and muscarinic antagonist activity of clozapine and haloperidol.
Topics: Acetylcholine; Animals; Cerebellum; Clozapine; Corpus Striatum; Cyclic GMP; Dopamine Antagonists; Ergolines; Haloperidol; Male; Mice; Muscarinic Antagonists; Oxotremorine; Quinpirole; Rats; Rats, Sprague-Dawley | 1996 |
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Clozapine; Diffusion; Domperidone; Epithelium; Flunitrazepam; Haloperidol; Humans; Kidney; Kinetics; Loperamide; Male; Mice; Mice, Inbred Strains; Ondansetron; Phenytoin; Recombinant Proteins; Structure-Activity Relationship; Swine; Tissue Distribution; Transfection | 1996 |
Behavioural interactions between 5-hydroxytryptophan, neuroleptic agents and 5-HT receptor antagonists in modifying rodent responding to aversive situations.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benperidol; Clozapine; Drug Interactions; Haloperidol; Male; Mice; Mice, Inbred Strains; Rats; Rats, Inbred Strains; Ritanserin; Serotonin; Serotonin Antagonists; Social Behavior; Sulpiride; Thioridazine | 1995 |
Amygdaloid neurons respond to clozapine rather than haloperidol in behaving rats pretreated with intra-amygdaloid amphetamine.
Topics: Amphetamine; Amygdala; Animals; Behavior, Animal; Clozapine; Haloperidol; Locomotion; Male; Rats; Rats, Sprague-Dawley | 1996 |
Clozapine is a partial agonist at cloned, human serotonin 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; CHO Cells; Clozapine; Cricetinae; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Receptors, Serotonin | 1996 |
[The affinities of mosapramine for the dopamine receptor subtypes in human cell lines expressing D2, D3 and D4 receptors].
Topics: Antipsychotic Agents; Benzazepines; Cell Line; Clozapine; Haloperidol; Humans; Raclopride; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D4; Receptors, Dopamine D5; Risperidone; Salicylamides; Spiperone | 1996 |
Long-term treatment with haloperidol or clozapine does not affect dopamine D4 receptors in rat frontal cortex.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine Antagonists; Drug Administration Schedule; Haloperidol; Male; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D4 | 1995 |
Monitoring of plasma clozapine levels and its metabolites in refractory schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Chromatography, High Pressure Liquid; Clozapine; Female; Haloperidol; Humans; Male; Schizophrenia | 1996 |
Subchronic administration of clozapine, but not haloperidol or metoclopramide, decreases dopamine D2 receptor messenger RNA levels in the nucleus accumbens and caudate-putamen in rats.
Topics: Actins; Animals; Antipsychotic Agents; Blotting, Northern; Brain Chemistry; Caudate Nucleus; Clozapine; Dopamine Antagonists; Haloperidol; Male; Metoclopramide; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Spiperone | 1996 |
Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT.
Topics: Adult; Antipsychotic Agents; Benperidol; Benzamides; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Humans; Iodine Radioisotopes; Male; Middle Aged; Prolactin; Prosencephalon; Pyrrolidines; Receptors, Dopamine D2; Schizophrenia, Paranoid; Tomography, Emission-Computed, Single-Photon | 1996 |
Glutamate agonist activity: implications for antipsychotic drug action and schizophrenia.
Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Schizophrenia | 1995 |
Contrasting effects of chronic clozapine, Seroquel(TM) (ICI 204,636) and haloperidol administration of deltaFosB-like immunoreactivity in the rodent forebrain.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dibenzothiazepines; Haloperidol; Immunohistochemistry; Male; Nerve Tissue Proteins; Neurons; Nucleus Accumbens; Prefrontal Cortex; Prosencephalon; Proto-Oncogene Proteins c-fos; Quetiapine Fumarate; Rats; Rats, Wistar; Time Factors | 1996 |
Injection of apomorphine--a test to predict individual different dopaminergic sensitivity?
Topics: Adrenocorticotropic Hormone; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Corticosterone; Dopamine Agonists; Drug Interactions; Haloperidol; Injections; Male; Motor Activity; Rats; Rats, Wistar; Stereotyped Behavior | 1995 |
Phencyclidine-induced increases in striatal neuron firing in behaving rats: reversal by haloperidol and clozapine.
Topics: Animals; Behavior, Animal; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Haloperidol; Locomotion; Male; Membrane Potentials; Neurons; Phencyclidine; Rats; Rats, Sprague-Dawley | 1995 |
3H-spiperone binding to peripheral mononuclear cells in psychiatric in-patients.
Topics: Adult; Binding, Competitive; Clozapine; Female; Haloperidol; Hospitalization; Humans; Lymphocytes; Male; Middle Aged; Schizophrenia; Spiperone | 1996 |
The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Haloperidol; Hippocampus; Hydroxyindoleacetic Acid; In Situ Hybridization; Ketanserin; Male; Organ Specificity; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reference Values; RNA, Messenger; Serotonin; Transcription, Genetic; Tritium | 1996 |
Different behavioral effects of haloperidol, clozapine and thioridazine in a concurrent lever pressing and feeding procedure.
Topics: Animals; Antipsychotic Agents; Clozapine; Conditioning, Operant; Feeding Behavior; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Thioridazine; Time Factors | 1996 |
Cognitive dysfunction in schizophrenia: comparison of treatment with atypical antipsychotic agents and conventional neuroleptic drugs.
Topics: Clozapine; Cognition; Fluphenazine; Haloperidol; Humans; Maze Learning; Risperidone; Schizophrenia | 1996 |
Typical and atypical neuroleptic drugs decrease platelet 3H-dopamine uptake in the rat.
Topics: Animals; Antipsychotic Agents; Blood Platelets; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Haloperidol; Male; Rats; Rats, Sprague-Dawley | 1996 |
The effects of raclopride on vacuous jaw movements in rats following acute administration.
Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Haloperidol; Injections, Intraperitoneal; Male; Mastication; Raclopride; Rats; Rats, Sprague-Dawley; Salicylamides; Stereotyped Behavior | 1996 |
Tics status.
Topics: Adolescent; Adult; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Haloperidol; Humans; Neurologic Examination; Recurrence; Tic Disorders; Tourette Syndrome | 1996 |
The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Cell Count; Clozapine; Frontal Lobe; Haloperidol; Immunohistochemistry; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1996 |
Chronic antipsychotic treatment alters glycine-stimulated NMDA receptor binding in rat brain.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Brain Chemistry; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glycine; Haloperidol; Male; Pimozide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Risperidone; Time Factors; Tritium | 1996 |
Effects of subchronic clozapine and haloperidol on striatal glutamatergic synapses.
Topics: Alternative Splicing; Animals; Base Sequence; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Genetic Variation; Glutamic Acid; Haloperidol; In Situ Hybridization; Ion Channels; Macromolecular Substances; Male; Microscopy, Immunoelectron; Nerve Endings; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA Probes; Synapses | 1996 |
Tardive lingual dystonia treated with clozapine.
Topics: Adult; Antipsychotic Agents; Clozapine; Dystonia; Haloperidol; Humans; Male; Schizophrenia; Tongue | 1996 |
Differential actions of typical and atypical antipsychotic drugs on dopamine release in the core and shell of the nucleus accumbens.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Haloperidol; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Differential effects of clozapine and haloperidol on dopamine receptor mRNA expression in rat striatum and cortex.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Clozapine; Corpus Striatum; Frontal Lobe; Gene Expression Regulation; Gyrus Cinguli; Haloperidol; In Situ Hybridization; Male; Nerve Tissue Proteins; Parietal Lobe; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Schizophrenia | 1996 |
Differential effects of D2- and D4-blocking neuroleptics on the procedural learning of schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Clozapine; Discrimination Learning; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Humans; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Orientation; Pattern Recognition, Visual; Problem Solving; Psychomotor Performance; Receptors, Dopamine D2; Receptors, Dopamine D4; Schizophrenia | 1996 |
Marked elevations of serum creatine kinase activity associated with antipsychotic drug treatment.
Topics: Adult; Antipsychotic Agents; Clozapine; Creatine Kinase; Female; Haloperidol; Humans; Male; Schizophrenia | 1996 |
Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Haloperidol; Immunoblotting; Immunohistochemistry; Male; Metoclopramide; Neurons; Phenotype; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Transcription Factors | 1996 |
Long-term treatment with chlorpromazine and haloperidol but not with sulpiride and clozapine markedly elevates neuropeptide Y-like immunoreactivity in the rat hypothalamus.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Benzazepines; Chlorpromazine; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Haloperidol; Hypothalamus; Male; Neuropeptide Y; Prazosin; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D1; Sulpiride | 1996 |
The effects of cyproheptadine on vacuous jaw movements in rats: a comparison with haloperidol and clozapine.
Topics: Animals; Clozapine; Cyproheptadine; Dose-Response Relationship, Drug; Haloperidol; Jaw; Male; Movement; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Inhibitory effects on the discriminative stimulus properties of D-amphetamine by classical and newer antipsychotics do not correlate with antipsychotic activity. Relation to effects on the reward system?
Topics: Amphetamine; Amphetamines; Animals; Antipsychotic Agents; Clozapine; Discrimination Learning; Dose-Response Relationship, Drug; Haloperidol; Male; Rats; Rats, Wistar; Reward | 1996 |
Differential effect of antipsychotics on place navigation of rats in the Morris water maze. A comparative study between novel and reference antipsychotics.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Maze Learning; Rats; Rats, Wistar; Risperidone | 1996 |
Behavioral effects of sertindole, risperidone, clozapine and haloperidol in Cebus monkeys.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Cebus; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Risperidone | 1996 |
Differential expression of c-fos mRNA in rat prefrontal cortex, striatum, N. accumbens and lateral septum after typical and atypical antipsychotics: an in situ hybridization study.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Brain; Clozapine; Corpus Striatum; Fluphenazine; Genes, fos; Haloperidol; In Situ Hybridization; Nucleus Accumbens; Piperazines; Prefrontal Cortex; Quinolones; Rats; RNA, Messenger; Septum Pellucidum; Sulpiride | 1996 |
Treatment with haloperidol or clozapine causes changes in dopamine receptors but not adenylate cyclase or protein kinase C in the rat forebrain.
Topics: Adenylyl Cyclases; Animals; Clozapine; Haloperidol; Male; Prosencephalon; Protein Kinase C; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Second Messenger Systems | 1996 |
Effects of clozapine metabolites and chronic clozapine treatment on rat brain GABAA receptors.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Drug Evaluation, Preclinical; GABA Antagonists; GABA-A Receptor Antagonists; Haloperidol; In Vitro Techniques; Logistic Models; Male; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Seroquel restores sensorimotor gating in phencyclidine-treated rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiazepines; Haloperidol; Male; Phencyclidine; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone | 1996 |
Chronic clozapine versus chronic haloperidol treatment: differential effects on electrically evoked dopamine efflux in the rat caudate putamen, but not in the nucleus accumbens.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Electric Stimulation; Haloperidol; Male; Nucleus Accumbens; Putamen; Rats | 1996 |
Haloperidol- and clozapine-induced enhancement of latent inhibition with extended conditioning: implications for the mechanism of action of neuroleptic drugs.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Conditioning, Psychological; Electroshock; Emotions; Haloperidol; Male; Rats; Rats, Wistar; Reinforcement, Psychology | 1997 |
Lack of cross-tolerance between haloperidol and clozapine towards Fos-protein induction in rat forebrain regions.
Topics: Animals; Clozapine; Drug Interactions; Drug Tolerance; Haloperidol; Male; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar | 1996 |
Effect of chronic treatment with typical and atypical neuroleptics on the expression of dopamine D2 and D3 receptors in rat brain.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; In Situ Hybridization; Limbic System; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Sulpiride | 1996 |
Regulation of ionotropic glutamate receptors following subchronic and chronic treatment with typical and atypical antipsychotics.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Male; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Glutamate; Salicylamides; Time Factors | 1996 |
Cerebrospinal fluid monoamine metabolites in childhood-onset schizophrenia.
Topics: Adolescent; Age of Onset; Child; Clozapine; Haloperidol; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Neurotransmitter Agents; Prolactin; Schizophrenia, Childhood; Treatment Outcome | 1997 |
Comparison of neurotensin responses to MDL 100,907, a selective 5HT2A antagonist, with clozapine and haloperidol.
Topics: Animals; Caudate Nucleus; Clozapine; Fluorobenzenes; Globus Pallidus; Haloperidol; Male; Neurotensin; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 1997 |
7-OH-DPAT differentially reverses clozapine- and haloperidol-induced increases in Fos-like immunoreactivity in the rodent forebrain.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine Agonists; Haloperidol; Immunohistochemistry; Male; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Tetrahydronaphthalenes | 1996 |
Chronic treatment with typical and atypical antipsychotics increases the AMPA-preferring form of AMPA receptor in rat brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Male; Pimozide; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Risperidone; Tritium | 1996 |
Antipsychotics with inverse agonist activity at the dopamine D3 receptor.
Topics: Animals; Antipsychotic Agents; Calcium; CHO Cells; Clozapine; Colforsin; Cricetinae; Cyclic AMP; DNA Replication; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Flupenthixol; Glioma; Haloperidol; Humans; Hybrid Cells; Naphthalenes; Neuroblastoma; Pertussis Toxin; Phenothiazines; Pimozide; Pyrrolidines; Quinpirole; Receptors, Dopamine D2; Receptors, Dopamine D3; Recombinant Proteins; Risperidone; Salicylamides; Second Messenger Systems; Sulpiride; Tetrahydronaphthalenes; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1996 |
Dopamine receptor subtypes: differential regulation after 8 months treatment with antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Benzamides; Benzazepines; Brain; Clozapine; Corpus Striatum; Haloperidol; Iodine Radioisotopes; Male; Organ Specificity; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Spiperone; Tetrahydronaphthalenes; Time Factors; Tritium; Up-Regulation | 1997 |
5-HT1A receptors are not involved in clozapine's lack of cataleptogenic potential.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Catalepsy; Clozapine; Haloperidol; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Ultrasonics; Vocalization, Animal | 1996 |
Effects of chronic neuroleptic treatments on dopamine D1 and D2 receptors: homogenate binding and autoradiographic studies.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzazepines; Chromatography, High Pressure Liquid; Clozapine; Haloperidol; Male; Neostriatum; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides | 1997 |
The effect of antipsychotic medication on relative cerebral blood perfusion in schizophrenia: assessment with technetium-99m hexamethyl-propyleneamine oxime single photon emission computed tomography.
Topics: Adult; Antipsychotic Agents; Basal Ganglia; Brain; Brain Mapping; Cerebellum; Cerebral Cortex; Chronic Disease; Clozapine; Female; Haloperidol; Humans; Male; Organotechnetium Compounds; Oximes; Psychiatric Status Rating Scales; Regional Blood Flow; Schizophrenia; Schizophrenic Psychology; Technetium Tc 99m Exametazime; Thiothixene; Tomography, Emission-Computed, Single-Photon; Trifluoperazine | 1997 |
Clozapine occupies high levels of dopamine D2 receptors.
Topics: Antipsychotic Agents; Binding, Competitive; Brain; Clozapine; Haloperidol; Humans; Radioligand Assay; Receptors, Dopamine D2; Receptors, Dopamine D4; Recombinant Proteins; Solubility; Thioridazine | 1997 |
Clozapine and dopamine.
Topics: Antipsychotic Agents; Clozapine; Dopamine; Drug Therapy, Combination; Haloperidol; Humans; Norepinephrine; Psychotic Disorders | 1997 |
Chronic treatment with antipsychotic drugs does not alter G protein alpha or beta subunit levels in rat brain.
Topics: Animals; Antipsychotic Agents; Benzazepines; Brain; Cell Membrane; Clozapine; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Haloperidol; Macromolecular Substances; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; Reference Values | 1996 |
The dose-response characteristics of rat oral dyskinesias with chronic haloperidol or clozapine administration.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Haloperidol; Male; Rats; Rats, Sprague-Dawley | 1997 |
Differential regulation of hippocampal AMPA and kainate receptor subunit expression by haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Clozapine; Entorhinal Cortex; Gene Expression Regulation; Haloperidol; Hippocampus; In Situ Hybridization; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; RNA, Messenger | 1996 |
Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice.
Topics: Animals; Benzodiazepines; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Motor Activity; Olanzapine; Phencyclidine; Pirenzepine; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT3; Serotonin Antagonists | 1997 |
Effects of clozapine and haloperidol on baseline levels of vacuous jaw movements in aged rats.
Topics: Aging; Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Mastication; Rats; Rats, Sprague-Dawley; Stereotyped Behavior | 1997 |
The behavioural effects of pramipexole, a novel dopamine receptor agonist.
Topics: Animals; Antiparkinson Agents; Benzazepines; Benzothiazoles; Body Temperature; Catalepsy; Clozapine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Injections, Subcutaneous; Levodopa; Male; Mice; Motor Activity; Pramipexole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Stereotyped Behavior; Sulpiride; Thiazoles | 1997 |
Effects of risperidone, clozapine and haloperidol on extracellular recordings of substantia nigra reticulata neurons of the rat brain.
Topics: Animals; Antipsychotic Agents; Basal Ganglia; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Injections, Intravenous; Male; Neurons; Rats; Rats, Wistar; Receptors, Dopamine D2; Reticulocytes; Risperidone; Serotonin Antagonists; Substantia Nigra | 1997 |
Effect of chronic antipsychotic drug treatment on preprosomatostatin and preprotachykinin A mRNA levels in the medial prefrontal cortex, the nucleus accumbens and the caudate putamen of the rat.
Topics: Animals; Antipsychotic Agents; Caudate Nucleus; Clozapine; Dopamine Antagonists; Haloperidol; Male; Nucleus Accumbens; Organ Specificity; Piperazines; Prefrontal Cortex; Protein Precursors; Putamen; Raclopride; Rats; Rats, Sprague-Dawley; RNA, Messenger; Salicylamides; Somatostatin; Tachykinins; Transcription, Genetic | 1997 |
Subchronic effects of clozapine and haloperidol on rats' forelimb force and duration during a press-while-licking task.
Topics: Animals; Antipsychotic Agents; Clozapine; Forelimb; Haloperidol; Male; Movement; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology | 1997 |
Differential regulation of dopamine receptors after chronic typical and atypical antipsychotic drug treatment.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzazepines; Clozapine; Dopamine Antagonists; Haloperidol; Male; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Salicylamides; Time Factors | 1997 |
Attenuation of antipsychotic-induced hyperprolactinemia with clozapine.
Topics: Adolescent; Amenorrhea; Antipsychotic Agents; Bromocriptine; Clozapine; Female; Fluphenazine; Galactorrhea; Haloperidol; Humans; Hyperprolactinemia; Prolactin; Psychotic Disorders; Thioridazine | 1997 |
Effects of YM-43611, a novel dopamine D2-like receptor antagonist, on immediate early gene expression in the rat forebrain.
Topics: Animals; Benzamides; Clozapine; Dopamine Antagonists; Haloperidol; Immunohistochemistry; Male; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D2 | 1997 |
BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; CHO Cells; Clozapine; Corpus Striatum; COS Cells; Cricetinae; Dibenzothiazepines; Dopamine; Female; Guinea Pigs; Haloperidol; Indoles; Kidney; Male; Microdialysis; Neuroblastoma; Nucleus Accumbens; Olanzapine; Piperazines; Pirenzepine; Prefrontal Cortex; Pyridines; Quetiapine Fumarate; Radioligand Assay; Rats; Rats, Sprague-Dawley; Risperidone; Tritium; Tumor Cells, Cultured | 1997 |
Regionally specific effects of haloperidol and clozapine on dopamine reuptake in the striatum.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Electrophysiology; Haloperidol; Male; Microelectrodes; Microinjections; Rats; Rats, Sprague-Dawley | 1997 |
[Zotepin--its value and potentials for further development].
Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiepins; Disease Models, Animal; Haloperidol; Humans; Rats; Schizophrenia | 1994 |
Severe extrapyramidal side effects when discontinuing clozapine and starting haloperidol.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Administration Schedule; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Haloperidol; Humans; Male; Schizophrenia; Substance Withdrawal Syndrome | 1997 |
Clozapine and haloperidol differentially affect AMPA and kainate receptor subunit mRNA levels in rat cortex and striatum.
Topics: Animals; Cerebral Cortex; Clozapine; Corpus Striatum; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; RNA, Messenger | 1997 |
Antipsychotic regulation of hippocampal dopamine receptor messenger RNA expression.
Topics: Animals; Antipsychotic Agents; Brain Mapping; Clozapine; Culture Techniques; Gene Expression; Haloperidol; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; RNA, Messenger; Synaptic Transmission | 1997 |
The involvement of dopamine D2 receptors, but not D3 or D4 receptors, in the rewarding effect of brain stimulation in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Reward; Salicylamides; Self Stimulation | 1997 |
Effects of clozapine, thioridazine, risperidone and haloperidol on behavioral tests related to extrapyramidal motor function.
Topics: Animals; Antipsychotic Agents; Cholinesterase Inhibitors; Clozapine; Conditioning, Operant; Extrapyramidal Tracts; Haloperidol; Jaw; Male; Rats; Rats, Sprague-Dawley; Risperidone; Tacrine; Thioridazine | 1997 |
Effects of ritanserin on haloperidol-induced dopamine (D2) receptor up-regulation in the rat.
Topics: Animals; Antipsychotic Agents; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Image Processing, Computer-Assisted; Male; Nucleus Accumbens; Quinolines; Rats; Rats, Wistar; Receptors, Dopamine D2; Ritanserin; Serotonin Antagonists; Up-Regulation | 1997 |
Prolonged treatment with haloperidol and clozapine in the rat: differential effects on spontaneous and theophylline-induced motor activity.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Locomotion; Male; Motor Activity; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Theophylline | 1997 |
Clozapine for the control of hemiballismus.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clozapine; Haloperidol; Humans; Hypnotics and Sedatives; Male; Movement Disorders; Phenobarbital; Pimozide | 1994 |
Clozapine and haloperidol modulate N-methyl-D-aspartate- and non-N-methyl-D-aspartate receptor-mediated neurotransmission in rat prefrontal cortical neurons in vitro.
Topics: Action Potentials; Animals; Antipsychotic Agents; Clozapine; Electric Stimulation; Haloperidol; In Vitro Techniques; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1997 |
The effects of kainic acid lesions on dopaminergic responses to haloperidol and clozapine.
Topics: Animals; Caudate Nucleus; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Haloperidol; Injections, Intraventricular; Kainic Acid; Male; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley | 1997 |
[123I]IBZM SPECT in patients treated with typical and atypical neuroleptics: relationship to drug plasma levels and extrapyramidal side effects.
Topics: Adult; Aged; Antipsychotic Agents; Basal Ganglia Diseases; Benperidol; Benzamides; Bipolar Disorder; Brain; Clozapine; Corpus Striatum; Depressive Disorder, Major; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Frontal Lobe; Haloperidol; Humans; Male; Middle Aged; Neurologic Examination; Psychiatric Status Rating Scales; Pyrrolidines; Receptors, Dopamine D2; Schizophrenia, Paranoid; Tomography, Emission-Computed, Single-Photon | 1997 |
Differential effects of acute administration of clozapine or haloperidol on local cerebral glucose utilization in the rat.
Topics: Animals; Antipsychotic Agents; Brain; Brain Mapping; Clozapine; Glucose; Haloperidol; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
MK-801 potentiates antidystonic effects of clozapine but not of haloperidol in mutant dystonic hamsters.
Topics: Animals; Anti-Dyskinesia Agents; Catalepsy; Clozapine; Cricetinae; Dizocilpine Maleate; Drug Synergism; Dystonia; Female; Haloperidol; Male; Mutation; Neuroprotective Agents | 1997 |
The effects of antipsychotic drugs on the mRNA levels of serotonin 5HT2A and 5HT2C receptors.
Topics: Animals; Antipsychotic Agents; Brain; Chlorpromazine; Clozapine; Down-Regulation; Haloperidol; Male; Organ Specificity; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; RNA, Messenger; Sulpiride; Time Factors; Transcription, Genetic; Up-Regulation | 1997 |
Disruption of latent inhibition in the rat by the 5-HT2 agonist DOI: effects of MDL 100,907, clozapine, risperidone and haloperidol.
Topics: Amphetamines; Animals; Antipsychotic Agents; Clozapine; Conditioning, Operant; Fluorobenzenes; Haloperidol; Male; Piperidines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Reinforcement, Psychology; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists | 1997 |
Regulation of NMDA receptor subunit messenger RNA levels in the rat brain following acute and chronic exposure to antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Time Factors | 1997 |
A naturalistic pilot study comparing haloperidol, clozapine, sertindole, and risperidone in partially responsive chronic schizophrenia or schizoaffective disorder.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Imidazoles; Indoles; Male; Psychotic Disorders; Risperidone; Schizophrenia; Treatment Failure | 1997 |
Clozapine compared with haloperidol for refractory schizophrenia.
Topics: Antipsychotic Agents; Clozapine; Haloperidol; Humans; Schizophrenia | 1998 |
The effects of the atypical antipsychotics clozapine, remoxipride and risperidone on the contractile characteristics of rat skeletal muscle in vitro.
Topics: Animals; Antipsychotic Agents; Caffeine; Clozapine; Dantrolene; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Halothane; In Vitro Techniques; Muscle Contraction; Muscle Relaxants, Central; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Remoxipride; Risperidone; Trifluoperazine | 1997 |
A histochemical demonstration of altered cytochrome oxidase activity in the rat brain by neuroleptics.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Densitometry; Electron Transport Complex IV; Fluphenazine; Haloperidol; Histocytochemistry; Male; Rats; Rats, Sprague-Dawley | 1998 |
A schizophrenic patient with an arrhythmic circadian rest-activity cycle.
Topics: Adult; Antipsychotic Agents; Bed Rest; Body Temperature; Catatonia; Chronic Disease; Circadian Rhythm; Clozapine; Haloperidol; Humans; Male; Melatonin; Motor Activity; Recurrence; Rest; Schizophrenia; Sleep; Time Factors | 1997 |
M100907, a selective 5-HT2A receptor antagonist and a potential antipsychotic drug, facilitates N-methyl-D-aspartate-receptor mediated neurotransmission in the rat medial prefrontal cortical neurons in vitro.
Topics: Animals; Antipsychotic Agents; Clozapine; Fluorobenzenes; Haloperidol; Male; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Serotonin Antagonists | 1998 |
Neuroleptics and dopamine transporters.
Topics: Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dopamine Antagonists; Haloperidol; Male; Neostriatum; Nucleus Accumbens; Olfactory Pathways; Prosencephalon; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Substantia Nigra; Tegmentum Mesencephali | 1998 |
Antipsychotic drug regulation of AMPA receptor affinity states and GluR1, GluR2 splice variant expression.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alternative Splicing; Animals; Antipsychotic Agents; Autoradiography; Binding, Competitive; Brain Chemistry; Clozapine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Haloperidol; In Situ Hybridization; Male; Pimozide; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Risperidone; RNA, Messenger; Sodium Chloride; Tritium | 1998 |
[Treatment with haloperidol of clozapine-triggered drug-induced delirium].
Topics: Antipsychotic Agents; Clozapine; Delirium; Haloperidol; Humans; Male; Middle Aged; Schizophrenia, Paranoid | 1997 |
The effects of kainic acid lesions on locomotor responses to haloperidol and clozapine.
Topics: Amphetamine; Animals; Antipsychotic Agents; Clozapine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Haloperidol; Kainic Acid; Male; Motor Activity; Rats; Rats, Sprague-Dawley | 1998 |
A test of the predictive validity of animal models of schizophrenia based on phencyclidine and D-amphetamine.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dextroamphetamine; Disease Models, Animal; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Male; Motor Activity; Phencyclidine; Predictive Value of Tests; Rats; Rats, Wistar; Schizophrenia; Social Behavior; Stereotyped Behavior | 1998 |
Effects of phencyclidine (PCP) and (+)MK-801 on sensorimotor gating in CD-1 mice.
Topics: Acoustic Stimulation; Animals; Apomorphine; Clozapine; Dextroamphetamine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Rats; Receptors, sigma; Reflex, Startle; Species Specificity | 1998 |
Response of the ventral pallidal/mediodorsal thalamic system to antipsychotic drug administration: involvement of the prefrontal cortex.
Topics: Animals; Antipsychotic Agents; Clozapine; Electrophysiology; Excitatory Amino Acid Agonists; Globus Pallidus; Haloperidol; Ibotenic Acid; Male; Membrane Potentials; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Thalamus | 1998 |
Olanzapine increases in vivo dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dopamine; Haloperidol; Male; Microdialysis; Neostriatum; Norepinephrine; Nucleus Accumbens; Olanzapine; Pirenzepine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 1998 |
MAO inhibitory side effects of neuroleptics and platelet serotonin content in schizophrenic patients.
Topics: Antipsychotic Agents; Blood Platelets; Clozapine; Drug Therapy, Combination; Haloperidol; Humans; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Probability; Reference Values; Schizophrenia; Serotonin | 1998 |
A novel computer-controlled conditioned avoidance apparatus for rats.
Topics: Amphetamines; Animals; Antipsychotic Agents; Avoidance Learning; Benzazepines; Clozapine; Computers; Cross-Over Studies; Dopamine Antagonists; Fluorobenzenes; Haloperidol; Male; Physical Conditioning, Animal; Piperidines; Raclopride; Rats; Rats, Sprague-Dawley; Salicylamides; Serotonin Antagonists; Serotonin Receptor Agonists | 1997 |
Chronic neuroleptic treatment alters expression of glial glutamate transporter GLT-1 mRNA in the striatum.
Topics: Amino Acid Transport System X-AG; Animals; Antipsychotic Agents; ATP-Binding Cassette Transporters; Biological Transport; Clozapine; Corpus Striatum; Haloperidol; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1998 |
Sertindole and dopamine D2 receptor occupancy in comparison to risperidone, clozapine and haloperidol - a 123I-IBZM SPECT study.
Topics: Adult; Antipsychotic Agents; Benzamides; Clozapine; Female; Haloperidol; Humans; Imidazoles; Indoles; Iodine Radioisotopes; Male; Middle Aged; Neostriatum; Pyrrolidines; Receptors, Dopamine D2; Risperidone; Schizophrenia; Tomography, Emission-Computed, Single-Photon | 1998 |
M100907 and clozapine, but not haloperidol or raclopride, prevent phencyclidine-induced blockade of NMDA responses in pyramidal neurons of the rat medial prefrontal cortical slice.
Topics: Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Antagonists; Fluorobenzenes; Haloperidol; In Vitro Techniques; Male; Patch-Clamp Techniques; Phencyclidine; Piperidines; Prefrontal Cortex; Pyramidal Cells; Raclopride; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Salicylamides; Serotonin Antagonists | 1998 |
Phenotypic characterization of neuroleptic-sensitive neurons in the forebrain: contrasting targets of haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine D2 Receptor Antagonists; Dynorphins; Enkephalins; Haloperidol; In Situ Hybridization; Male; Neurons; Oligonucleotide Probes; Organ Specificity; Phenotype; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Transcription, Genetic | 1998 |
Effects of subchronic administration of clozapine, thioridazine and haloperidol on tests related to extrapyramidal motor function in the rat.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Conditioning, Operant; Haloperidol; Jaw; Male; Movement; Rats; Rats, Sprague-Dawley; Tacrine; Thioridazine | 1998 |
Acute and chronic administration of clozapine produces greater proconvulsant actions than haloperidol on focal hippocampal seizures in freely moving rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Hippocampus; Injections, Intraperitoneal; Kindling, Neurologic; Male; Rats; Rats, Wistar; Seizures; Time Factors | 1998 |
Iodine-123-iodobenzamide SPECT assessment of dopamine D2 receptor occupancy in riperidone-treated schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Benzamides; Brain; Clozapine; Contrast Media; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Iodine Radioisotopes; Male; Middle Aged; Pyrrolidines; Receptors, Dopamine D2; Risperidone; Schizophrenia; Tomography, Emission-Computed, Single-Photon | 1998 |
Enhancement of latent inhibition in the rat at a high dose of clozapine.
Topics: Animals; Antipsychotic Agents; Association Learning; Clozapine; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Haloperidol; Inhibition, Psychological; Rats; Rats, Sprague-Dawley | 1998 |
The effects of the atypical antipsychotic amperozide on vacuous jaw movements in rats: a novel dose response profile.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Haloperidol; Jaw; Male; Movement Disorders; Piperazines; Rats; Rats, Sprague-Dawley | 1998 |
Induction of Fos protein by antipsychotic drugs in rat brain following kainic acid-induced limbic-cortical neuronal loss.
Topics: Animals; Antipsychotic Agents; Brain; Brain Diseases; Cell Count; Clozapine; Dose-Response Relationship, Drug; Gene Expression; Genes, fos; Haloperidol; Kainic Acid; Limbic System; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1998 |
Olanzapine-induced Fos expression in the rat forebrain; cross-tolerance with haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Corticosterone; Drug Tolerance; Haloperidol; Male; Olanzapine; Pirenzepine; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Time Factors | 1998 |
S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: II. Functional profile in comparison to clozapine and ha
Topics: Amphetamines; Animals; Antipsychotic Agents; Attention; Clozapine; Cognition; Discrimination Learning; Electroencephalography; Haloperidol; Humans; Male; Mice; Mice, Inbred ICR; Motor Activity; Prolactin; Pyrrolidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
Does clozapine treatment cause brain disease?
Topics: Adult; Age Factors; Brain Diseases; Child; Clozapine; Drug Therapy, Combination; Haloperidol; Humans; Magnetic Resonance Imaging; Schizophrenia | 1998 |
Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Corpus Striatum; Haloperidol; Infusion Pumps; Male; Microdialysis; Neurotensin; Nucleus Accumbens; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Preferential blockade by clozapine of hyperlocomotion induced by non-competitive NMDA antagonist MK-801.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Hyperkinesis; Mice; Mice, Inbred BALB C; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Stereotyped Behavior; Sulpiride | 1998 |
Clozapine and haloperidol block the induction of behavioral sensitization to amphetamine and associated genomic responses in rats.
Topics: Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Gene Expression Regulation; Genes, fos; Haloperidol; In Situ Hybridization; Injections, Subcutaneous; Male; Motor Activity; Neurotensin; Nucleus Accumbens; Peptide Fragments; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation.
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Clozapine; Deoxyglucose; Excitatory Amino Acid Antagonists; Haloperidol; Ketamine; Male; Rats; Rats, Sprague-Dawley | 1998 |
Clozapine antagonizes the induction of striatal Fos expression by typical neuroleptics.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Haloperidol; Immunohistochemistry; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1998 |
Modification of haloperidol-induced pattern of c-fos expression by serotonin agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
Clozapine, haloperidol, and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic, and nigrostriatal dopamine and serotonin release.
Topics: Animals; Brain; Cerebral Cortex; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Limbic System; Male; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Serotonin; Substantia Nigra; Tissue Distribution | 1998 |
Alpha1-adrenergic, D1, and D2 receptors interactions in the prefrontal cortex: implications for the modality of action of different types of neuroleptics.
Topics: Animals; Antipsychotic Agents; Benzazepines; Cerebral Cortex; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electric Stimulation; Electrophysiology; Haloperidol; Injections, Intravenous; Iontophoresis; Neural Inhibition; Prazosin; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Dopamine D1; Receptors, Dopamine D2; Sulpiride | 1998 |
Chronical haloperidol and clozapine treatment in rats: differential RNA display analysis, behavioral studies and serum level determination.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; DNA Primers; Female; Haloperidol; Motor Activity; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Some, but not all, antipsychotic drugs potentiate a low level of prepulse inhibition shown by rats of the Wistar strain.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Benzodiazepines; Clozapine; Haloperidol; Imidazoles; Indoles; Injections, Intraperitoneal; Male; Neural Inhibition; Olanzapine; Pirenzepine; Prazosin; Rats; Rats, Wistar; Reflex, Startle; Remoxipride; Risperidone; Ritanserin; Serotonin Antagonists | 1997 |
Influence of typical and atypical antipsychotics on neuropeptide Y-like immunoreactivity and NPY mRNA expression in rat striatum.
Topics: Adrenergic Antagonists; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; In Situ Hybridization; Injections, Intraperitoneal; Male; Neuropeptide Y; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Dopamine; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Sulpiride | 1998 |
Antipsychotic drugs induce similar effects on the release of dopamine and noradrenaline in the medial prefrontal cortex of the rat brain.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Dopamine; Dopamine Agonists; Extracellular Space; Haloperidol; Male; Norepinephrine; Olanzapine; Piperazines; Pirenzepine; Prefrontal Cortex; Rats; Rats, Wistar; Reference Values; Risperidone; Tetrahydronaphthalenes; Thiazoles | 1998 |
Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Haloperidol; Ketamine; Male; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 1998 |
Haloperidol, raclopride, and eticlopride induce microcatalepsy during operant performance in rats, but clozapine and SCH 23390 do not.
Topics: Animals; Antipsychotic Agents; Benzazepines; Catalepsy; Clozapine; Conditioning, Operant; Haloperidol; Male; Raclopride; Rats; Rats, Sprague-Dawley; Salicylamides | 1998 |
Prolongation of QT interval in isolated feline hearts by antipsychotic drugs.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Cats; Clozapine; Electrocardiography; Haloperidol; Heart; Humans; Imidazoles; In Vitro Techniques; Indoles; Risperidone | 1998 |
Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Gyrus Cinguli; Haloperidol; HSP70 Heat-Shock Proteins; Immediate-Early Proteins; Immunohistochemistry; Ketanserin; Mice; Motor Activity; Proto-Oncogene Proteins c-fos; Ritanserin; Serotonin Antagonists | 1998 |
Clozapine-induced dopamine levels in the rat striatum and nucleus accumbens are not affected by muscarinic antagonism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Carbachol; Cardiotonic Agents; Chromatography, High Pressure Liquid; Clozapine; Corpus Striatum; Dopamine; Drug Interactions; Haloperidol; Male; Microdialysis; Muscarinic Antagonists; Nucleus Accumbens; Rats; Rats, Wistar; Scopolamine | 1998 |
The effect of E-5842, a sigma receptor ligand and potential atypical antipsychotic, on Fos expression in rat forebrain.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Clozapine; Gene Expression; Haloperidol; Ligands; Male; Nucleus Accumbens; Oncogene Proteins v-fos; Prefrontal Cortex; Prosencephalon; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Triazoles | 1998 |
Involvement of 5-HT6 receptors in nigro-striatal function in rodents.
Topics: Adrenergic Agents; Animals; Basal Ganglia Diseases; Benzazepines; Catalepsy; Clozapine; Corpus Striatum; Haloperidol; Male; Mice; Oxidopamine; Prosencephalon; Pyrimidines; Rats; Receptors, Serotonin; Serotonin Antagonists | 1998 |
Involvement of adenosine A2A receptors in the induction of c-fos expression by clozapine and haloperidol.
Topics: Animals; Antipsychotic Agents; Clozapine; Gene Expression; Genes, fos; Haloperidol; Male; Neurons; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles | 1999 |
Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Catalepsy; Clozapine; Drug Interactions; Haloperidol; Histamine; Histamine Antagonists; Imidazoles; Male; Methylhistamines; Mice; Olanzapine; Pirenzepine; Receptor, Serotonin, 5-HT2A; Receptors, Histamine H3; Receptors, Serotonin; Serotonin Antagonists | 1999 |
Acutely administered clozapine does not modify naloxone-induced withdrawal jumping in morphine-dependent mice.
Topics: Analgesics; Animals; Antipsychotic Agents; Clonidine; Clozapine; Haloperidol; Male; Mice; Morphine Dependence; Naloxone; Narcotic Antagonists; Substance Withdrawal Syndrome | 1999 |
Body weight and leptin plasma levels during treatment with antipsychotic drugs.
Topics: Adipose Tissue; Analysis of Variance; Antipsychotic Agents; Benzodiazepines; Body Mass Index; Body Weight; Clozapine; Haloperidol; Hospitalization; Humans; Leptin; Mental Disorders; Olanzapine; Pirenzepine; Proteins; Weight Gain | 1999 |
Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartate-induced increase in intracellular calcium concentration: involvement of protein kinase.
Topics: Animals; Antipsychotic Agents; Calcium; Cells, Cultured; Chlorpromazine; Clozapine; Dopamine Antagonists; Frontal Lobe; Guanidines; Haloperidol; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, sigma; Sulpiride | 1999 |
S-16924 [(R)-2-[1-[2-(2,3-dihydro-benzo[1,4]dioxin-5-yloxy)-ethyl]- pyrrolidin-3yl]-1-(4-fluorophenyl)-ethanone], a novel, potential antipsychotic with marked serotonin1A agonist properties: III. Anxiolytic actions in comparison with clozapine and haloper
Topics: Aggression; Animals; Antipsychotic Agents; Autoreceptors; Clorazepate Dipotassium; Clozapine; Columbidae; Conflict, Psychological; Haloperidol; Male; Maze Learning; Mice; Pyrrolidines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors; Vocalization, Animal | 1999 |
Chronic oral haloperidol and clozapine in rats: A behavioral evaluation.
Topics: Administration, Oral; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dyskinesia, Drug-Induced; Exploratory Behavior; Female; Habituation, Psychophysiologic; Haloperidol; Locomotion; Rats; Rats, Sprague-Dawley; Time Factors; Weight Gain | 1999 |
A cost-effectiveness clinical decision analysis model for schizophrenia.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cost-Benefit Analysis; Decision Support Systems, Clinical; Haloperidol; Humans; Markov Chains; Olanzapine; Pirenzepine; Quality-Adjusted Life Years; Risperidone; Schizophrenia; Treatment Outcome; United States | 1998 |
Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus.
Topics: Animals; Antipsychotic Agents; Caudate Nucleus; Clozapine; Dopamine; Dopamine Antagonists; Extracellular Space; Haloperidol; Macaca mulatta; Magnetic Resonance Imaging; Male; Microdialysis; Neurotransmitter Agents; Prefrontal Cortex | 1999 |
Molecular and behavioral effects mediated by Gs-coupled adenosine A2a, but not serotonin 5-Ht4 or 5-Ht6 receptors following antipsychotic administration.
Topics: Adenosine; Animals; Antipsychotic Agents; Behavior, Animal; Caffeine; Catalepsy; Clozapine; Corpus Striatum; Cyclic AMP; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Genes, fos; GTP-Binding Protein alpha Subunits, Gs; Haloperidol; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Dopamine D2; Receptors, Purinergic P1; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Second Messenger Systems; Serotonin; Serotonin Antagonists; Theophylline | 1999 |
Sexual disturbances during clozapine and haloperidol treatment for schizophrenia.
Topics: Adult; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Drug Monitoring; Female; Haloperidol; Humans; Libido; Male; Orgasm; Patient Compliance; Schizophrenia; Sex Factors; Sexual Dysfunctions, Psychological | 1999 |
Clozapine, but not haloperidol, prevents the functional hyperactivity of N-methyl-D-aspartate receptors in rat cortical neurons induced by subchronic administration of phencyclidine.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1999 |
Spontaneous slow and fast MEG activity in male schizophrenics treated with clozapine.
Topics: Adult; Antipsychotic Agents; Clozapine; Electroencephalography; Haloperidol; Humans; Magnetoencephalography; Male; Schizophrenia | 1999 |
Effects of chronic treatment with typical and atypical antipsychotic drugs on the rat striatum.
Topics: Animals; Antipsychotic Agents; Autoradiography; Clozapine; Corpus Striatum; Dopamine D2 Receptor Antagonists; Haloperidol; Magnetic Resonance Imaging; Male; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Salicylamides | 1999 |
Chronic haloperidol and clozapine administration increases the number of cortical NMDA receptors in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antipsychotic Agents; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Dizocilpine Maleate; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Spiperone; Tritium | 1999 |
Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo.
Topics: 3T3 Cells; Animals; Antipsychotic Agents; Benzodiazepines; Cell Line; Clozapine; Dendrites; Fluorobenzenes; Haloperidol; Mianserin; Mice; Olanzapine; Piperidines; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Recombinant Proteins; Risperidone; Ritanserin; Serotonin Antagonists; Transfection | 1999 |
Differential induction of Fos-like-immunoreactivity in the extended amygdala after haloperidol and clozapine.
Topics: Amygdala; Animals; Antipsychotic Agents; Clozapine; Haloperidol; Immunohistochemistry; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1999 |
Region-specific induction of deltaFosB by repeated administration of typical versus atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Caudate Nucleus; Clozapine; Drug Administration Schedule; Haloperidol; Immunohistochemistry; Male; Nucleus Accumbens; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Sprague-Dawley | 1999 |
Effects of NRA0045, NRA0160, and NRA0215 on regional Fos-like immunoreactivity in the rat brain.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Corpus Striatum; Haloperidol; Immunohistochemistry; Male; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Pyrrolidines; Rats; Rats, Wistar; Thiazoles | 1999 |
Antidepressants and atypical neuroleptics induce Fos-like immunoreactivity in the central extended amygdala.
Topics: Amygdala; Animals; Antidepressive Agents; Antipsychotic Agents; Citalopram; Clozapine; Gene Expression Regulation; Genes, fos; Haloperidol; Imipramine; Male; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 1999 |
Stimulation of dopamine release in the bed nucleus of stria terminalis. A trait of atypical antipsychotics?
Topics: Amygdala; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dopamine; Haloperidol; Indoles; Male; Olanzapine; Pirenzepine; Pyridines; Raclopride; Rats; Rats, Sprague-Dawley; Risperidone; Salicylamides; Thalamus | 1999 |
Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Brain Mapping; Cerebral Cortex; Clozapine; Down-Regulation; Gene Expression; Haloperidol; Hippocampus; Limbic System; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; RNA, Messenger | 1999 |
Regulation of ionotropic glutamate receptors in the rat brain in response to the atypical antipsychotic seroquel (quetiapine fumarate).
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Corpus Striatum; Dibenzothiazepines; Gene Expression Regulation; Haloperidol; Hippocampus; Male; Nucleus Accumbens; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Transcription, Genetic | 1999 |
Clozapine pretreatment modifies haloperidol-elicited forebrain Fos induction: a regionally-specific double dissociation.
Topics: Animals; Catalepsy; Clozapine; Drug Interactions; Haloperidol; Immunoblotting; Immunohistochemistry; Oncogene Proteins v-fos; Prosencephalon; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 1999 |
Effects of acute and chronic administration of olanzapine in comparison to clozapine and haloperidol on extracellular recordings of substantia nigra reticulata neurons in the rat brain.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Haloperidol; Male; Neurons; Olanzapine; Pirenzepine; Rats; Rats, Wistar; Substantia Nigra | 1999 |
Clozapine-associated elevation in serum triglycerides.
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Clozapine; Female; Haloperidol; Hospital Records; Hospitalization; Humans; Hypertriglyceridemia; Male; Middle Aged; Psychotic Disorders; Retrospective Studies; Sex Factors; Triglycerides | 1999 |
Chronic clozapine, but not haloperidol, alters the response of mesoprefrontal dopamine neurons to stress and clozapine challenges in rats.
Topics: Animals; Antipsychotic Agents; Biogenic Monoamines; Chromatography, High Pressure Liquid; Clozapine; Dopamine; Haloperidol; Neurons; Prefrontal Cortex; Rats; Restraint, Physical; Stress, Psychological | 1999 |
In vivo receptor occupancy of NRA0045, a putative atypical antipsychotic, in rats.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Cerebral Cortex; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Nucleus Accumbens; Pyrrolidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-1; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Schizophrenia; Thiazoles | 1999 |
Mice with reduced NMDA receptor expression display behaviors related to schizophrenia.
Topics: Animals; Antipsychotic Agents; Antisocial Personality Disorder; Behavior, Animal; Calcium Signaling; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Haloperidol; Male; Mice; Mice, Knockout; Motor Activity; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenic Psychology; Serotonin Antagonists; Sexual Behavior, Animal; Social Behavior; Stereotyped Behavior | 1999 |
Pentadecapeptide BPC 157 attenuates disturbances induced by neuroleptics: the effect on catalepsy and gastric ulcers in mice and rats.
Topics: Animals; Anti-Ulcer Agents; Antipsychotic Agents; Catalepsy; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Fluphenazine; Haloperidol; Male; Mice; Orientation; Peptic Ulcer; Peptide Fragments; Proteins; Rats; Rats, Wistar; Sulpiride; Time Factors | 1999 |
Neurochemical changes in the entopeduncular nucleus and increased oral behavior in rats treated subchronically with clozapine or haloperidol.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzazepines; Binding Sites; Binding, Competitive; Clozapine; Dopamine Agonists; Dopamine Antagonists; Entopeduncular Nucleus; Female; Glutamate Decarboxylase; Haloperidol; In Situ Hybridization; Mastication; Neostriatum; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; RNA, Messenger; Salicylamides; Time Factors | 1999 |
Effects of treatment with haloperidol, chlorpromazine, and clozapine on protein kinase C (PKC) and phosphoinositide-specific phospholipase C (PI-PLC) activity and on mRNA and protein expression of PKC and PLC isozymes in rat brain.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Brain; Cerebral Cortex; Chlorpromazine; Clozapine; Haloperidol; Hippocampus; Isoenzymes; Male; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Protein Binding; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Specific Pathogen-Free Organisms; Time Factors; Type C Phospholipases; Visual Cortex | 1999 |
Differential effects of haloperidol and clozapine on ionotropic glutamate receptors in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Aspartic Acid; Binding Sites; Brain; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1999 |
Dopamine receptor antagonists modulate glucose uptake in rat pheochromocytoma (PC12) cells.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Benzazepines; Biological Transport; Chlorpromazine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Fluphenazine; Glucose; Haloperidol; PC12 Cells; Pimozide; Rats; Receptors, Dopamine D2; Spiperone; Sulpiride; Tritium | 1999 |
Disruption of prepulse inhibition following N-methyl-D-aspartate infusion into the ventral hippocampus is antagonized by clozapine but not by haloperidol: a possible model for the screening of atypical antipsychotics.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Excitatory Amino Acid Antagonists; Haloperidol; Hippocampus; Infusions, Parenteral; Male; N-Methylaspartate; Rats; Rats, Wistar; Reflex, Startle | 1999 |
Effects of atypical antipsychotic drugs vs. haloperidol on expression of heat shock protein in the discrete brain regions of phencyclidine-treated rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Corpus Striatum; Gene Expression Regulation; Gyrus Cinguli; Haloperidol; HSP70 Heat-Shock Proteins; Male; Nucleus Accumbens; Olanzapine; Phencyclidine; Pirenzepine; Prefrontal Cortex; Rats; Rats, Wistar; Risperidone; RNA, Messenger | 1999 |
Effects of haloperidol and clozapine on tongue dynamics during licking in CD-1, BALB/c and C57BL/6 mice.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dopamine Antagonists; Feeding Behavior; Haloperidol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Species Specificity; Tongue | 1999 |
S18327 (1-[2-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)piperid-1-yl]ethyl]3-phenyl imidazolin-2-one), a novel, potential antipsychotic displaying marked antagonist properties at alpha(1)- and alpha(2)-adrenergic receptors: II. Functional profile and a multipara
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Aggression; Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Clozapine; Cocaine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Extrapyramidal Tracts; Haloperidol; Imidazoles; Isoxazoles; Male; Mice; Pain Measurement; Protein Binding; Rats; Rats, Wistar; Receptors, Histamine; Receptors, Muscarinic | 2000 |
Clozapine reversal of the deficits in coordinated movement induced by D2 receptor blockade does not depend upon antagonism of alpha2 adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Ataxia; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Idazoxan; Loxapine; Male; Muscarinic Antagonists; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Scopolamine; Yohimbine | 1999 |
Behavioral evidence of depolarization block of dopamine neurons after chronic treatment with haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Brain; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Haloperidol; Male; Neurons; Rats; Rats, Long-Evans; Reward; Sensory Thresholds; Time Factors | 2000 |
Effects of chronic haloperidol and clozapine on vacuous chewing and dopamine-mediated jaw movements in rats: evaluation of a revised animal model of tardive dyskinesia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; Clozapine; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dyskinesia, Drug-Induced; Haloperidol; Jaw; Male; Mastication; Quinpirole; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Serotonin Antagonists | 1999 |
Effects of a novel neurotensin peptide analog given extracranially on CNS behaviors mediated by apomorphine and haloperidol.
Topics: Animals; Apomorphine; Behavior, Animal; Body Temperature; Catalepsy; Clozapine; Haloperidol; Injections, Intraperitoneal; Male; Mice; Motor Activity; Neurotensin; Peptide Fragments; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine; Fluorobenzenes; Haloperidol; Male; Microdialysis; Nucleus Accumbens; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Risperidone; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium | 2000 |
Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Cytoskeletal Proteins; Gene Expression; Haloperidol; Male; Nerve Tissue Proteins; Olanzapine; Phencyclidine; Pirenzepine; Rats; Rats, Wistar; Risperidone; RNA, Messenger; Tissue Distribution | 2000 |
Effects of antipsychotic drugs on metabolite ratios in rat brain in vivo.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Aspartic Acid; Benzodiazepines; Brain; Choline; Clozapine; Creatine; Haloperidol; Magnetic Resonance Spectroscopy; Male; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley | 2000 |
Immunosuppressive effects of clozapine and haloperidol: enhanced production of the interleukin-1 receptor antagonist.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Immunosuppressive Agents; Interferon-gamma; Male; Receptors, Interleukin-1; Receptors, Interleukin-6; Schizophrenia | 2000 |
The discriminative stimulus properties of the atypical antipsychotic olanzapine in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Discrimination Learning; Generalization, Psychological; Haloperidol; Male; Olanzapine; Pirenzepine; Raclopride; Rats; Rats, Sprague-Dawley; Risperidone; Ritanserin; Scopolamine | 2000 |
Pharmacology of quinpirole-stimulated [35S]GTPgammaS binding: discrepancy with receptor binding profile.
Topics: Animals; Benzazepines; Binding, Competitive; Clorgyline; Clozapine; Corpus Striatum; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Membranes; Monoamine Oxidase Inhibitors; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Selegiline; Spiperone; Sulfur Radioisotopes; Thiazoles | 2000 |
Differential patterns of induction of NGFI-B, Nor1 and c-fos mRNAs in striatal subregions by haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Clozapine; DNA-Binding Proteins; Drug Administration Schedule; Haloperidol; In Situ Hybridization; Male; Neostriatum; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Nuclear Receptor Subfamily 4, Group A, Member 1; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Dopamine D2; Receptors, Steroid; RNA, Messenger; Schizophrenia; Transcription Factors; Tretinoin | 2000 |
Dissociation of haloperidol, clozapine, and olanzapine effects on electrical activity of mesocortical dopamine neurons and dopamine release in the prefrontal cortex.
Topics: Action Potentials; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dopamine; Haloperidol; Male; Neurons; Olanzapine; Pirenzepine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2000 |
Inhibitory effects of clozapine and other antipsychotic drugs on noradrenaline transporter in cultured bovine adrenal medullary cells.
Topics: Adrenal Medulla; Animals; Antipsychotic Agents; Binding, Competitive; Carrier Proteins; Cattle; Cells, Cultured; Clozapine; Desipramine; Dose-Response Relationship, Drug; Female; Haloperidol; Kinetics; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Oocytes; Symporters; Tritium; Xenopus | 2000 |
Predicting how equipotent doses of chlorpromazine, haloperidol, sulpiride, raclopride and clozapine reduce locomotor activity in mice.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Haloperidol; Male; Mice; Motor Activity; Raclopride; Sulpiride | 2000 |
Intracellular modulation of NMDA receptor function by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Blotting, Northern; Cells, Cultured; Clozapine; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Haloperidol; Male; Neostriatum; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2000 |
Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Behavior, Animal; Buspirone; Clozapine; Desipramine; Diazepam; Dose-Response Relationship, Drug; Female; Haloperidol; Injections, Intraperitoneal; Male; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Social Isolation; Stress, Psychological; Vocalization, Animal; Zimeldine | 2000 |
Antagonist properties of the novel antipsychotic, S16924, at cloned, human serotonin 5-HT2C receptors: a parallel phosphatidylinositol and calcium accumulation comparison with clozapine and haloperidol.
Topics: Animals; Antipsychotic Agents; Calcium; CHO Cells; Clozapine; Cricetinae; Haloperidol; Humans; Phosphatidylinositols; Pyrrolidines; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Serotonin Antagonists; Transfection; Tritium | 2000 |
Effects of neurotensin receptor antagonists on the firing rate of rat ventral pallidum neurons.
Topics: Action Potentials; Animals; Clozapine; Dopamine Antagonists; Electrophysiology; Globus Pallidus; Haloperidol; Male; Neurons; Pyrazoles; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin; Serotonin Antagonists | 2000 |
Reconstitution of functional dopamine D(2s) receptor by co-expression of amino- and carboxyl-terminal receptor fragments.
Topics: Animals; Apomorphine; Binding, Competitive; Clozapine; Colforsin; COS Cells; Cyclic AMP; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Membranes; Peptide Fragments; Pergolide; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Recombinant Fusion Proteins; Spiperone; Transfection; Tritium | 2000 |
[Diminution of hand writing area and D2-dopamine receptor blockade. Results from treatment with typical and atypical neuroleptics].
Topics: Adult; Aged; Antipsychotic Agents; Benzamides; Clozapine; Dopamine Antagonists; Female; Haloperidol; Handwriting; Humans; Male; Middle Aged; Neostriatum; Pyrrolidines; Receptors, Dopamine; Risperidone; Schizophrenia, Paranoid; Therapeutic Equivalency; Tomography, Emission-Computed, Single-Photon | 2000 |
Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds.
Topics: Animals; Benzazepines; Brain; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Hypothalamus; Male; Nucleus Accumbens; Phosphorylation; Raclopride; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2000 |
Differential effects of acute administration of haloperidol and clozapine on ethanol-induced ascorbic acid release in rat striatum.
Topics: Animals; Antipsychotic Agents; Ascorbic Acid; Central Nervous System Depressants; Clozapine; Corpus Striatum; Ethanol; Female; Haloperidol; Rats; Rats, Wistar | 2000 |
Potentiation of ethanol-induced loss of the righting reflex by ascorbic acid in mice: interaction with dopamine antagonists.
Topics: Animals; Ascorbic Acid; Benzazepines; Clozapine; Dopamine Antagonists; Drug Synergism; Ethanol; Female; Haloperidol; Mice; Receptors, Dopamine D2; Reflex; Sleep; Sulpiride | 2000 |
The latent inhibition model dissociates between clozapine, haloperidol, and ritanserin.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Conditioning, Psychological; Drinking Behavior; Electric Stimulation; Haloperidol; Male; Rats; Rats, Wistar; Ritanserin | 2000 |
Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Binding, Competitive; Caudate Nucleus; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Guanidines; Guanosine Triphosphate; Haloperidol; Heterotrimeric GTP-Binding Proteins; Indans; Kinetics; Magnesium; Male; Oxazines; Protein Binding; Putamen; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Remoxipride; Sodium; Specific Pathogen-Free Organisms; Sulfones; Sulpiride; Tetrahydronaphthalenes | 2001 |
5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Male; Microdialysis; Olanzapine; Piperazines; Pirenzepine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Sensitivity and Specificity; Synaptic Transmission; Thiazoles; Time Factors | 2000 |
Effects of antipsychotic drugs on cholecystokinin and preprotachykinin (substance P) mRNA expression in the rat hippocampal formation.
Topics: Animals; Antipsychotic Agents; Cholecystokinin; Clozapine; Gene Expression Regulation; Haloperidol; Hippocampus; Male; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance P; Tachykinins; Transcription, Genetic | 2000 |
Contrasting patterns and cellular specificity of transcriptional regulation of the nuclear receptor nerve growth factor-inducible B by haloperidol and clozapine in the rat forebrain.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; DNA-Binding Proteins; Drug Administration Schedule; Dynorphins; Enkephalins; Gene Expression Regulation; Haloperidol; In Situ Hybridization; Male; Neurons; Neurotensin; Nuclear Receptor Subfamily 4, Group A, Member 1; Nucleus Accumbens; Organ Specificity; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors | 2000 |
Subchronic treatment with either clozapine, olanzapine or haloperidol produces a hyposensitive response of the rat cortical cells to N-methyl-D-aspartate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Haloperidol; In Vitro Techniques; Male; N-Methylaspartate; Olanzapine; Pharmaceutical Vehicles; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
Severe self-injurious behavior associated with treatment-resistant schizophrenia: treatment with maintenance electroconvulsive therapy.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Resistance; Electroconvulsive Therapy; Haloperidol; Humans; Male; Risperidone; Schizophrenia; Schizophrenic Psychology; Self-Injurious Behavior | 2000 |
[Mental disorders in acute neuroleptic poisoning].
Topics: Acute Disease; Adult; Age Distribution; Antipsychotic Agents; Chlorpromazine; Clozapine; Female; Haloperidol; Humans; Male; Mental Disorders; Middle Aged; Suicide, Attempted | 1999 |
Comparison of the effects of clozapine, haloperidol, chlorpromazine and d-amphetamine on performance on a time-constrained progressive ratio schedule and on locomotor behaviour in the rat.
Topics: Animals; Antipsychotic Agents; Central Nervous System Stimulants; Chlorpromazine; Clozapine; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Haloperidol; Motor Activity; Rats; Rats, Wistar; Reinforcement Schedule | 2000 |
Effect of chlorpromazine and clozapine on plasma concentrations of haloperidol in a patient with schizophrenia.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Clozapine; Drug Interactions; Drug Therapy, Combination; Haloperidol; Humans; Male; Schizophrenia | 2000 |
Low-dose clozapine pretreatment partially prevents haloperidol-induced deficits in conditioned active avoidance.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Basal Ganglia Diseases; Catalepsy; Clozapine; Conditioning, Classical; Drug Interactions; Haloperidol; Male; Rats; Rats, Wistar | 2000 |
The effect of the antipsychotic drug mosapramine on the expression of Fos protein in the rat brain: comparison with haloperidol, clozapine and risperidone.
Topics: Animals; Antipsychotic Agents; Benzazepines; Brain; Clozapine; Corpus Striatum; Gene Expression Regulation; Genes, fos; Haloperidol; Immunohistochemistry; Male; Neurons; Nucleus Accumbens; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Risperidone | 2000 |
Clozapine does not induce a motor impairment in operant responding for heat reinforcement.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Body Temperature; Clozapine; Colon; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Haloperidol; Hot Temperature; Injections, Intraperitoneal; Motor Activity; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Temperature | 2000 |
The 5-HT2 antagonist ritanserin blocks dopamine re-uptake in the rat frontal cortex.
Topics: Animals; Clozapine; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Frontal Lobe; Haloperidol; Ketanserin; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Risperidone; Ritanserin; Serotonin Antagonists; Synaptosomes; Tritium | 2000 |
Increased dopamine d(2) receptor occupancy and elevated prolactin level associated with addition of haloperidol to clozapine.
Topics: Adult; Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Corpus Striatum; Drug Therapy, Combination; Haloperidol; Humans; Male; Prolactin; Raclopride; Receptors, Dopamine D2; Schizophrenia; Tomography, Emission-Computed | 2001 |
Effects of MK801 and neuroleptics on prepulse inhibition: re-examination in two strains of rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Haloperidol; Hippocampus; Male; Neural Inhibition; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Species Specificity | 2000 |
Haloperidol and clozapine increase neural activity in the rat prefrontal cortex.
Topics: Action Potentials; Animals; Antipsychotic Agents; Clozapine; Electrophysiology; Haloperidol; Male; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia | 2001 |
Double activity imaging reveals distinct cellular targets of haloperidol, clozapine and dopamine D(3) receptor selective RGH-1756.
Topics: Animals; Antipsychotic Agents; Brain; Cell Count; Clozapine; Densitometry; Genes, Immediate-Early; Haloperidol; Immunohistochemistry; In Situ Hybridization; Injections, Intraperitoneal; Male; Neurons; Piperazines; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; RNA, Messenger; Thiazoles; Tissue Distribution | 2001 |
Uncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptors alter the mRNA expression of proteins associated with the NMDA receptor complex.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cerebral Cortex; Clozapine; Dizocilpine Maleate; Down-Regulation; Excitatory Amino Acid Antagonists; Haloperidol; Image Processing, Computer-Assisted; In Situ Hybridization; Isoenzymes; Male; Membrane Proteins; Nerve Tissue Proteins; Protein Kinase C; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; SAP90-PSD95 Associated Proteins | 2001 |
FosB in rat striatum: normal regional distribution and enhanced expression after 6-month haloperidol administration.
Topics: Animals; Cell Count; Clozapine; Drug Administration Schedule; Gene Expression Regulation; Haloperidol; Male; Neostriatum; Neural Pathways; Neurons; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Schizophrenia; Up-Regulation | 2001 |
Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Hallucinogens; Haloperidol; Male; Mice; Models, Animal; Phencyclidine; Schizophrenia; Social Behavior; Substance Withdrawal Syndrome | 2001 |
Hyperactivity and disruption of prepulse inhibition induced by N-methyl-D-aspartate stimulation of the ventral hippocampus and the effects of pretreatment with haloperidol and clozapine.
Topics: Animals; Clozapine; Dopamine Antagonists; Excitatory Amino Acid Agonists; Haloperidol; Hippocampus; Hyperkinesis; Male; Motor Activity; N-Methylaspartate; Neural Inhibition; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Serotonin Antagonists | 2001 |
Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7,263 treatment courses.
Topics: Alanine Transaminase; Antipsychotic Agents; Aspartate Aminotransferases; Chi-Square Distribution; Clozapine; Female; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Haloperidol; Humans; Liver; Male; Perazine; Perphenazine; Retrospective Studies; Schizophrenia; Statistics, Nonparametric | 2001 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Atypical antipsychotic effects of quetiapine fumarate in animal models.
Topics: Amphetamine; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Clozapine; Disease Models, Animal; Female; Haloperidol; Immobilization; Male; Mice; Phencyclidine; Rats; Rats, Wistar; Schizophrenia; Schizophrenia, Paranoid | 2000 |
Stimulus properties of 7-OH-DPAT versus auto- and postsynaptic receptor-specific doses of quinpirole.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Clozapine; Dopamine Antagonists; Female; Haloperidol; Maternal Behavior; Motivation; Motor Activity; Pimozide; Rats | 2001 |
Atypical antipsychotic drugs: how much better are they?
Topics: Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Haloperidol; Humans; Olanzapine; Pirenzepine | 2001 |
Frequency of sexual dysfunctions in patients with schizophrenia on haloperidol, clozapine or risperidone.
Topics: Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Male; Risperidone; Schizophrenia; Sexual Dysfunction, Physiological | 2001 |
Tyrosine augments acute clozapine- but not haloperidol-induced dopamine release in the medial prefrontal cortex of the rat: an in vivo microdialysis study.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Extracellular Space; Haloperidol; Male; Microdialysis; Neostriatum; Neural Pathways; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Tyrosine | 2001 |
Generalization of serotonin (5-HT)1A agonists and the antipsychotics, clozapine, ziprasidone and S16924, but not haloperidol, to the discriminative stimuli elicited by PD128,907 and 7-OH-DPAT.
Topics: Animals; Antipsychotic Agents; Benzopyrans; Clozapine; Discrimination Learning; Dopamine; Dopamine Agonists; Haloperidol; Humans; Male; Oxazines; Piperazines; Pyrrolidines; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Tetrahydronaphthalenes; Thiazoles | 2001 |
No support for regional selectivity in clozapine-treated patients: a PET study with [(11)C]raclopride and [(11)C]FLB 457.
Topics: Adult; Antipsychotic Agents; Brain; Clozapine; Corpus Striatum; Female; Haloperidol; Humans; Male; Middle Aged; Pyrrolidines; Raclopride; Receptors, Dopamine D2; Salicylamides; Schizophrenia; Schizophrenia, Paranoid; Tomography, Emission-Computed | 2001 |
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes | 2001 |
Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia.
Topics: Amphetamine; Animals; Antipsychotic Agents; Benzodiazepinones; Central Nervous System Stimulants; Clozapine; Disease Models, Animal; Drug Evaluation, Preclinical; Haloperidol; Locomotion; Male; Pyridines; Rats; Rats, Wistar; Reflex, Startle; Schizophrenia | 2001 |
Neuroleptic malignant syndrome with antidepressant/antipsychotic drug combination.
Topics: Aged; Antidepressive Agents; Antipsychotic Agents; Clozapine; Drug Combinations; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome | 2001 |
Different regulation of RGS2 mRNA by haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Male; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred F344; RGS Proteins; RNA, Messenger; Tissue Distribution | 2001 |
Interactions between environmental stimulation and antipsychotic drug effects on forebrain c-fos activation.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Cell Count; Clozapine; Dose-Response Relationship, Drug; Environment, Controlled; Haloperidol; Immunohistochemistry; Male; Motor Activity; Neurons; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar | 2001 |
Pharmacological evaluation of (+)-2- [123I]A-69024: a radioligand for in vivo studies of dopamine D1 receptors.
Topics: Animals; Benzazepines; Brain; Cerebellum; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Injections, Intravenous; Iodine Radioisotopes; Ketanserin; Ligands; Male; Papaverine; Rats; Rats, Wistar; Receptors, Dopamine D1; Spiperone; Stereoisomerism; Tetrahydroisoquinolines; Tetrahydronaphthalenes; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2001 |
BDNF mRNA expression in rat hippocampus and prefrontal cortex: effects of neonatal ventral hippocampal damage and antipsychotic drugs.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Axotomy; Brain-Derived Neurotrophic Factor; Clozapine; Down-Regulation; Gene Expression Regulation, Developmental; Haloperidol; Hippocampus; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schizophrenia | 2001 |
Chronic treatment with clozapine, but not haloperidol, increases striatal ecto-5'-nucleotidase activity in rats.
Topics: 5'-Nucleotidase; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antipsychotic Agents; Clozapine; Haloperidol; Hippocampus; Hydrolysis; Male; Neostriatum; Rats; Rats, Wistar; Synaptosomes | 2001 |
Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Clozapine; Dibenzothiazepines; Dopamine Antagonists; Haloperidol; Humans; Neurons; Norepinephrine; Olanzapine; Piperazines; Pirenzepine; Quetiapine Fumarate; Rats; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Risperidone; Serotonin; Serotonin Antagonists; Thiazoles | 2001 |
Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA.
Topics: Animals; Antipsychotic Agents; Clozapine; Drug Administration Schedule; GTP-Binding Proteins; Haloperidol; In Situ Hybridization; Male; Neostriatum; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RGS Proteins; Risperidone; RNA, Messenger; Signal Transduction; Up-Regulation | 2001 |
Atypical neuroleptic drugs downregulate dopamine sensitivity in rat cortical and striatal astrocytes.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Antipsychotic Agents; Astrocytes; Benzodiazepines; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Clozapine; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Down-Regulation; Haloperidol; Intracellular Fluid; Neostriatum; Olanzapine; Pirenzepine; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D4; Risperidone; Serotonin Antagonists; Sulpiride | 2001 |
Extended treatment with typical and atypical antipsychotic drugs differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum.
Topics: Animals; Antipsychotic Agents; Benzamides; Benzazepines; Benzodiazepines; Chlorpromazine; Clozapine; Corpus Striatum; Dose-Response Relationship, Drug; Haloperidol; Male; Muscimol; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, GABA-A | 2001 |
Real-time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation state.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alternative Splicing; Animals; Binding, Competitive; Butaclamol; Calcium; CHO Cells; Clozapine; Cricetinae; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Genotype; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Lisuride; Mutation; Plasmids; Receptors, Dopamine; Receptors, Dopamine D2; Recombinant Proteins; Sulfur Radioisotopes; Time Factors | 2001 |
Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation.
Topics: Amino Acids; Animals; Antipsychotic Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Clozapine; Dopamine; Excitatory Amino Acids; Haloperidol; Indicators and Reagents; Male; Microdialysis; Olanzapine; Pirenzepine; Prefrontal Cortex; Rats; Reflex, Startle; Social Isolation | 2001 |
Comparison of the effects of clozapine, chlorpromazine, and haloperidol on membrane lateral heterogeneity.
Topics: Antipsychotic Agents; Calorimetry, Differential Scanning; Chlorpromazine; Clozapine; Haloperidol; Liposomes; Membrane Lipids; Membranes, Artificial; Microscopy, Fluorescence | 2001 |
Evaluation of dopamine D-2 receptor occupancy by clozapine, risperidone, and haloperidol in vivo in the rodent and nonhuman primate brain using 18F-fallypride.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzamides; Brain; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Fluorine Radioisotopes; Haloperidol; Macaca mulatta; Male; Neostriatum; Pyrrolidines; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Risperidone; Tomography, Emission-Computed | 2001 |
Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat.
Topics: Adrenalectomy; Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Desoxycorticosterone; Haloperidol; Male; Neurotransmitter Agents; Orchiectomy; Progesterone; Rats; Rats, Sprague-Dawley; Steroids | 2001 |
Effects of chronic haloperidol and clozapine treatments on frontal and caudate neurochemistry in schizophrenia.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antipsychotic Agents; Caudate Nucleus; Clozapine; Female; Frontal Lobe; Haloperidol; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Schizophrenia | 2001 |
Effects of the atypical neuroleptic clozapine on micturition parameters in anesthetized rats.
Topics: Anesthesia; Animals; Antipsychotic Agents; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electric Stimulation; Female; Haloperidol; Hypogastric Plexus; Pyridines; Pyrroles; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Urinary Bladder; Urination; Urination Disorders | 2001 |
Efficacy of antipsychotic agents at human 5-HT(1A) receptors determined by [3H]WAY100,635 binding affinity ratios: relationship to efficacy for G-protein activation.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Membranes; Piperazines; Piperidines; Pyridines; Pyrimidinones; Pyrrolidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Thiazoles; Thioridazine; Tritium | 2001 |
Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine.
Topics: Animals; Benzodiazepines; Binding, Competitive; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Haloperidol; HeLa Cells; Humans; Ileum; In Vitro Techniques; Indoles; Lysergic Acid; Muscle Contraction; Olanzapine; Ondansetron; Pirenzepine; Quetiapine Fumarate; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Risperidone; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfur Radioisotopes; Tritium; Tropisetron | 2001 |
Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex.
Topics: Animals; Clozapine; Fluorobenzenes; Glutamic Acid; Haloperidol; Male; Microdialysis; Phencyclidine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 2001 |
A behavioural pattern analysis of hypoglutamatergic mice--effects of four different antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dizocilpine Maleate; Dopamine Antagonists; Drug Combinations; Excitatory Amino Acid Antagonists; Fluorobenzenes; Glutamic Acid; Haloperidol; Injections, Intraperitoneal; Male; Mice; Motor Activity; Piperidines; Risperidone; Serotonin Antagonists | 2001 |
Decreased pallidal GABA following reverse microdialysis with clozapine, but not haloperidol.
Topics: Animals; Antipsychotic Agents; Calcium; Clozapine; Dose-Response Relationship, Drug; Down-Regulation; Dyskinesia, Drug-Induced; Extracellular Space; Female; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Microdialysis; Neurons; Potassium; Rats; Rats, Sprague-Dawley; Tetrodotoxin | 2001 |
[Heart rate variability in schizophrenic patients treated with antipsychotic agents].
Topics: Adult; Antipsychotic Agents; Arrhythmias, Cardiac; Benzodiazepines; Clozapine; Female; Haloperidol; Heart Rate; Humans; Male; Middle Aged; Olanzapine; Pirenzepine; Schizophrenia | 2001 |
Minimal effects of JL 13, a pyridobenzoxazepine derivative with an antipsychotic potential, on circulating prolactin levels in male rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Hyperprolactinemia; Male; Pituitary Gland, Anterior; Prolactin; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 2002 |
Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Cholinesterase Inhibitors; Clozapine; Corpus Striatum; Haloperidol; Male; Nucleus Accumbens; Olanzapine; Oxotremorine; Piperazines; Pirenzepine; Rats; Rats, Sprague-Dawley; Risperidone; Scopolamine; Sulpiride; Thiazoles; Thioridazine | 2002 |
Effects of antipsychotic drugs on operant responding after acute and repeated administration.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Conditioning, Operant; Dibenzothiazepines; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Male; Olanzapine; Pirenzepine; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Remoxipride; Risperidone; Thioridazine; Time Factors | 2002 |
Differential effects of typical and atypical antipsychotic drugs on striosome and matrix compartments of the striatum.
Topics: Animals; Antipsychotic Agents; Clozapine; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Haloperidol; Male; Muscarinic Antagonists; Neostriatum; Neurons; Neuropil; Proto-Oncogene Proteins c-fos; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Serotonin Antagonists | 2002 |
Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT(2C) receptors in vivo.
Topics: Animals; Antipsychotic Agents; Chromatography, High Pressure Liquid; Clozapine; Dopamine; Electrochemistry; Extracellular Space; Haloperidol; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Risperidone; Serotonin Antagonists | 2002 |
The effects of neuroleptics on the GABA-induced Cl- current in rat dorsal root ganglion neurons: differences between some neuroleptics.
Topics: Animals; Antipsychotic Agents; Cells, Cultured; Chloride Channel Agonists; Chloride Channels; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Ganglia, Spinal; Haloperidol; Incidence; Membrane Potentials; Piperazines; Piperidines; Quetiapine Fumarate; Rats; Rats, Wistar; Seizures | 2002 |
Differential effects of haloperidol and clozapine on [(3)H]cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Behavior, Animal; Blotting, Western; Brain; Cloning, Molecular; Clozapine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Haloperidol; Isoenzymes; Kinetics; Oligonucleotide Probes; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Complementary; RNA, Messenger | 2002 |
Myoclonic and generalized tonic clonic seizures during combined treatment with low doses of clozapine and haloperidol.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Haloperidol; Humans; Seizures | 2002 |
Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Clozapine; Dialysis Solutions; Dopamine Antagonists; Extracellular Space; Haloperidol; Hippocampus; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Microdialysis; Olanzapine; Piperazines; Pirenzepine; Rats; Rats, Wistar; Risperidone; Serotonin Antagonists; Thiazoles; Thioridazine | 2002 |
Sub-chronic treatment with classical but not atypical antipsychotics produces morphological changes in rat nigro-striatal dopaminergic neurons directly related to "early onset" vacuous chewing.
Topics: Amisulpride; Animals; Antipsychotic Agents; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Dyskinesia, Drug-Induced; Haloperidol; Male; Mastication; Neostriatum; Nerve Degeneration; Neural Pathways; Neurons; Rats; Rats, Sprague-Dawley; Risperidone; Substance Withdrawal Syndrome; Substantia Nigra; Sulpiride | 2002 |
Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action.
Topics: Animals; Antipsychotic Agents; Brain; Catalepsy; Clozapine; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Haloperidol; Isomerism; Male; Neostriatum; Neurons; Nucleus Accumbens; Prolactin; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Schizophrenia; Synaptic Transmission; Up-Regulation | 2002 |
Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2.
Topics: Animals; Antipsychotic Agents; Binding Sites; Biological Transport; Brain; Brain Chemistry; Clozapine; Drug Administration Schedule; Fluoxetine; Haloperidol; In Situ Hybridization; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Paroxetine; Piperazines; Rats; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Clozapine and haloperidol reinstate latent inhibition following its disruption during amphetamine withdrawal.
Topics: Amphetamine; Animals; Antipsychotic Agents; Avoidance Learning; Central Nervous System Stimulants; Clozapine; Haloperidol; Inhibition, Psychological; Male; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2002 |
5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Clozapine; Corpus Striatum; Dopamine Antagonists; Fluorobenzenes; Haloperidol; Indophenol; Male; Microdialysis; Nucleus Accumbens; Piperazines; Piperidines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2002 |
The effects of dopamine and D2 receptor antagonists on pituitary hormone secretion are intact in mice lacking dopamine D2L receptor.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Dopamine Antagonists; Growth Hormone; Haloperidol; Mice; Mice, Knockout; Pituitary Gland; Prolactin; Radioimmunoassay; Receptors, Dopamine D2 | 2002 |
Regional selectivity in clozapine treatment?
Topics: Antipsychotic Agents; Carbon Radioisotopes; Cerebellum; Clozapine; Corpus Striatum; Frontal Lobe; Haloperidol; Humans; Pyrrolidines; Receptors, Dopamine D2; Salicylamides; Temporal Lobe; Tomography, Emission-Computed | 2002 |
Evaluation of the neurotoxic activity of typical and atypical neuroleptics: relevance to iatrogenic extrapyramidal symptoms.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Brain; Cell Cycle; Cell Survival; Clozapine; DNA Fragmentation; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Iatrogenic Disease; Mice; Mice, Inbred ICR; Neurons; Neurotoxins; Perphenazine; Pregnancy; Risperidone; Tumor Cells, Cultured | 2001 |
Differential effects of the antipsychotics haloperidol and clozapine on G protein measures in mononuclear leukocytes of patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Binding, Competitive; Brain Chemistry; Clozapine; Dopamine; Dopamine Agonists; Female; GTP-Binding Proteins; Haloperidol; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Parkinson Disease; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Muscarinic; Schizophrenia; Up-Regulation | 2001 |
Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Antidepressive Agents; Antipsychotic Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Clozapine; Haloperidol; Hippocampus; Imipramine; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Disruption of prepulse inhibition of startle reflex in a neurodevelopmental model of schizophrenia: reversal by clozapine, olanzapine and risperidone but not by haloperidol.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Disease Models, Animal; Haloperidol; Hippocampus; Male; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley; Reflex, Startle; Reserpine; Schizophrenia | 2002 |
Antipsychotic profile of 5-[2-[4-(6-fluoro-1H-indole-3-yl)piperidin-1-yl]ethyl]-4-(4-fluorophenyl)thiazole-2-carboxylic acid amide (NRA0562) in rats.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Male; Piperidines; Rats; Rats, Wistar; Risperidone; Thiazoles | 2002 |
Prolactin responses to acute clomipramine and haloperidol of male schizophrenic patients in a drug-free state and after treatment with clozapine or with olanzapine.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Clomipramine; Clozapine; Haloperidol; Humans; Hypothalamo-Hypophyseal System; Male; Middle Aged; Olanzapine; Pirenzepine; Prolactin; Psychiatric Status Rating Scales; Receptors, Dopamine D2; Receptors, Serotonin; Schizophrenia; Treatment Outcome | 2002 |
Sexual side effects of novel antipsychotic medications.
Topics: Adult; Antipsychotic Agents; Clozapine; Erectile Dysfunction; Fluphenazine; Haloperidol; Humans; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Schizophrenic Psychology; Sexual Behavior | 2002 |
Convergent evidence from microdialysis and presynaptic immunolabeling for the regulation of gamma-aminobutyric acid release in the globus pallidus following acute clozapine or haloperidol administration in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Clozapine; Dopamine Antagonists; Extracellular Space; Female; Forelimb; GABA Antagonists; gamma-Aminobutyric Acid; Globus Pallidus; Haloperidol; Hindlimb; Immunohistochemistry; Injections, Subcutaneous; Microdialysis; Motor Activity; Neural Inhibition; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 2002 |
Striatal volume changes in the rat following long-term administration of typical and atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Caudate Nucleus; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Haloperidol; Hypertrophy; Male; Neostriatum; Neuronal Plasticity; Neurons; Putamen; Rats; Rats, Sprague-Dawley; Risperidone; Schizophrenia; Time Factors | 2002 |
Chronic antipsychotic drug treatment induces long-lasting expression of fos and jun family genes and activator protein 1 complex in the rat prefrontal cortex.
Topics: Animals; Antipsychotic Agents; Clozapine; DNA-Binding Proteins; Drug Administration Schedule; Gene Expression Regulation; Gyrus Cinguli; Haloperidol; Male; Neurons; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; RNA, Messenger; Schizophrenia; Transcription Factor AP-1; Transcription, Genetic; Up-Regulation | 2002 |
The effect of chronic treatment with clozapine and haloperidol on stimulus control by DOM.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Discrimination, Psychological; DOM 2,5-Dimethoxy-4-Methylamphetamine; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Male; Rats; Rats, Inbred F344; Receptor, Serotonin, 5-HT2A; Serotonin Receptor Agonists | 2002 |
Differential activation of orexin neurons by antipsychotic drugs associated with weight gain.
Topics: Amphetamine; Animals; Antipsychotic Agents; Body Weight; Carrier Proteins; Cell Count; Central Nervous System Stimulants; Clozapine; Dopamine Antagonists; Fornix, Brain; Haloperidol; Hypothalamic Area, Lateral; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Neurons; Neuropeptides; Orexins; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Weight Gain | 2002 |
Neuroleptic malignant syndrome: an experience of four cases.
Topics: Adolescent; Adult; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Neuroleptic Malignant Syndrome | 1998 |
Correlation of antipsychotic and prolactin concentrations in children and adolescents acutely treated with haloperidol, clozapine, or olanzapine.
Topics: Adolescent; Adult; Antipsychotic Agents; Benzodiazepines; Child; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Olanzapine; Pirenzepine; Prolactin; Psychotic Disorders; Schizophrenia | 2002 |
Differences in the effects of haloperidol and clozapine on brain serotonin and dopamine metabolism and on tests related to extrapyramidal functions in rats.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Clozapine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Time Factors | 2002 |
Induction of differential patterns of local cerebral glucose metabolism and immediate-early genes by acute clozapine and haloperidol.
Topics: Animals; Antimetabolites; Antipsychotic Agents; Autoradiography; Brain Chemistry; Clozapine; Deoxyglucose; Dopamine Antagonists; Gene Expression Regulation; Genes, Immediate-Early; Glucose; Haloperidol; In Situ Hybridization; Male; Nerve Net; Oligonucleotide Probes; Rats; Rats, Long-Evans; RNA, Messenger | 2002 |
Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chlorpromazine; Clozapine; Haloperidol; Ion Channels; Male; Olanzapine; Phencyclidine; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2002 |
Effect of acute and chronic administration of the selective 5-HT2C receptor antagonist SB-243213 on midbrain dopamine neurons in the rat: an in vivo extracellular single cell study.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Action Potentials; Analysis of Variance; Animals; Apomorphine; beta-Cyclodextrins; Cell Count; Clozapine; Cyclodextrins; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Haloperidol; Indoles; Male; Neurons; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Substantia Nigra; Ventral Tegmental Area | 2002 |
Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Female; Haloperidol; Maze Learning; Memory, Short-Term; Neural Pathways; Nicotine; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Dopamine; Risperidone; Schizophrenia | 2002 |
Differential effects of chronic haloperidol and clozapine administration on glutamatergic transmission in the fronto-parietal cortex in rats: microdialysis and electrophysiological studies.
Topics: Animals; Aspartic Acid; Clozapine; Electrophysiology; Frontal Lobe; Glutamic Acid; Haloperidol; Male; Microdialysis; Parietal Lobe; Rats; Rats, Wistar | 2002 |
Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration.
Topics: Animals; Antipsychotic Agents; Blotting, Northern; Brain-Derived Neurotrophic Factor; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression Regulation; Haloperidol; Hippocampus; In Situ Hybridization; Male; Rats; Rats, Wistar; Remoxipride; Risperidone; Ritanserin; RNA, Messenger; Time Factors | 2002 |
The effects of novel antipsychotics on glucose and lipid levels.
Topics: Antipsychotic Agents; Benzodiazepines; Blood Glucose; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clozapine; Diabetes Mellitus, Type 2; Dibenzothiazepines; Female; Haloperidol; Humans; Hyperlipidemias; Lipids; Male; Middle Aged; Olanzapine; Pirenzepine; Psychotic Disorders; Quetiapine Fumarate; Retrospective Studies; Risk Factors; Risperidone; Triglycerides; Weight Gain | 2002 |
Chlorpromazine inhibits the glucocorticoid receptor-mediated gene transcription in a calcium-dependent manner.
Topics: Animals; Antipsychotic Agents; Calcimycin; Calcium; Calcium Channel Blockers; Cell Line; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; Chlorpromazine; Clozapine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrenes; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Haloperidol; Histamine; Histamine H1 Antagonists; Ionophores; Mammary Tumor Virus, Mouse; Mice; Nifedipine; Phorbol Esters; Phosphodiesterase Inhibitors; Protein Kinase C; Protein Kinase C-alpha; Pyrilamine; Pyrrolidinones; Raclopride; Receptors, Glucocorticoid; Remoxipride; Sulfonamides; Sulpiride; Tetradecanoylphorbol Acetate; Thionucleotides; Transcription, Genetic; Type C Phospholipases | 2002 |
Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data.
Topics: Adult; Aged; Antipsychotic Agents; Arrhythmias, Cardiac; Clozapine; Cohort Studies; Confidence Intervals; Death, Sudden, Cardiac; Female; Haloperidol; Heart Arrest; Humans; Male; Medicaid; Middle Aged; Risperidone; Schizophrenia; Thioridazine; United States | 2002 |
Antipsychotic drug treatment induces differential gene expression in the rat cortex.
Topics: Animals; Antipsychotic Agents; Calcineurin; Calcium-Binding Proteins; Cerebral Cortex; Chromogranin A; Chromogranins; Clozapine; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation; Haloperidol; In Situ Hybridization; Inhibitor of Differentiation Protein 2; Male; Membrane Glycoproteins; Munc18 Proteins; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; rab GTP-Binding Proteins; Rats; Rats, Wistar; Repressor Proteins; RNA, Messenger; Son of Sevenless Proteins; Synaptotagmins; Transcription Factors; Vesicular Transport Proteins | 2002 |
Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism.
Topics: Acetylcholine; Animals; Antipsychotic Agents; Butyrophenones; Clozapine; Dibenzothiazepines; Dopamine; Haloperidol; Isoxazoles; Male; Microdialysis; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1 | 2002 |
Glucose intolerance with atypical antipsychotics.
Topics: Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Bayes Theorem; Benzodiazepines; Chlorpromazine; Clozapine; Diabetes Mellitus; Glucose Intolerance; Haloperidol; Humans; Hyperglycemia; Olanzapine; Pirenzepine; Risk Factors; Risperidone; World Health Organization | 2002 |
Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Auditory Perceptual Disorders; Bungarotoxins; Clozapine; Dihydro-beta-Erythroidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Evoked Potentials, Auditory; Haloperidol; Hippocampus; Male; Mice; Mice, Inbred DBA; Nicotinic Antagonists; Receptors, Nicotinic; Time Factors | 2003 |
Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats.
Topics: Analysis of Variance; Animals; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Somatosensory Cortex | 2002 |
Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzodiazepines; Brain-Derived Neurotrophic Factor; Clozapine; Dopamine Agents; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Hippocampus; In Situ Hybridization; Levodopa; Male; Olanzapine; Pirenzepine; Rats; Rats, Wistar; RNA, Messenger | 2003 |
Clozapine decreases rat brain dehydroepiandrosterone and dehydroepiandrosterone sulfate levels.
Topics: Animals; Brain; Brain Chemistry; Clozapine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dopamine Antagonists; GABA Antagonists; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2003 |
Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents.
Topics: Adrenalectomy; Animals; Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Clozapine; Corticosterone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Haloperidol; Male; Olanzapine; Pirenzepine; Pregnanolone; Progesterone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Risperidone | 2003 |
Discriminative stimulus properties in rats of the novel antipsychotic quetiapine.
Topics: Amisulpride; Analysis of Variance; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dibenzothiazepines; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Generalization, Psychological; Haloperidol; Loxapine; Quetiapine Fumarate; Quinoxalines; Rats; Rats, Wistar; Risperidone; Sulpiride | 2002 |
Insight in persons with schizophrenia: effects of switching from conventional neuroleptics to atypical antipsychotics.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition; Cognition Disorders; Female; Haloperidol; Humans; Male; Olanzapine; Patient Compliance; Pirenzepine; Risperidone; Schizophrenia; Severity of Illness Index; Treatment Outcome | 2002 |
The influence of typical and atypical neuroleptic drugs in the production of interleukin-2 and interferon-gamma in vitro.
Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Clozapine; Haloperidol; Humans; In Vitro Techniques; Interferon-gamma; Interleukin-2; Schizophrenia | 2002 |
Differential effects of haloperidol, risperidone, and clozapine exposure on cholinergic markers and spatial learning performance in rats.
Topics: Animals; Brain; Choline O-Acetyltransferase; Cholinergic Fibers; Clozapine; Haloperidol; Male; Maze Learning; Rats; Rats, Wistar; Risperidone; Spatial Behavior | 2003 |
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Cyclic AMP; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Humans; Isoxazoles; Norepinephrine; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Quinolones; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Risperidone; Thiazoles; Transfection; Yohimbine | 2003 |
Systemic administration of MK-801 produces an abnormally persistent latent inhibition which is reversed by clozapine but not haloperidol.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Conditioning, Psychological; Disease Models, Animal; Dizocilpine Maleate; Drinking Behavior; Haloperidol; Inhibition, Psychological; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 2003 |
Acute effects of antipsychotic drugs on cardiovascular responses to stress.
Topics: Animals; Antipsychotic Agents; Blood Pressure; Clozapine; Dose-Response Relationship, Drug; Exploratory Behavior; Haloperidol; Heart Rate; Male; Motor Activity; Rats; Rats, Inbred F344; Risperidone; Stress, Psychological | 2003 |
Effects of long-term antipsychotic treatment on NMDA receptor binding and gene expression of subunits.
Topics: Animals; Antipsychotic Agents; Autoradiography; Clozapine; Gene Expression; Haloperidol; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2003 |
Clozapine and tardive dyskinesia.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Administration Schedule; Dyskinesia, Drug-Induced; Female; Fluphenazine; Haloperidol; Humans; Longitudinal Studies; Schizophrenia, Paranoid | 2003 |
Comparative effectiveness of antipsychotic drugs.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clinical Trials as Topic; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Haloperidol; Humans; Olanzapine; Pirenzepine; Psychotic Disorders; Research Design; Risperidone; Schizophrenia; Treatment Outcome | 2003 |
Comparative effectiveness of antipsychotic drugs.
Topics: Antipsychotic Agents; Chronic Disease; Clozapine; Cohort Effect; Cohort Studies; Haloperidol; Humans; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Research Design; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2003 |
Comparative effectiveness of antipsychotic drugs.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Haloperidol; Humans; Olanzapine; Pirenzepine; Randomized Controlled Trials as Topic; Reproducibility of Results; Research Design; Risperidone; Schizophrenia; Treatment Outcome | 2003 |
Comparative effectiveness of antipsychotic drugs.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Haloperidol; Humans; Olanzapine; Pirenzepine; Research Design; Research Support as Topic; Risperidone; Schizophrenia; Treatment Outcome | 2003 |
Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Haloperidol; In Vitro Techniques; Isoxazoles; Magnesium; Male; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Time Factors | 2003 |
Halothane attenuated haloperidol and enhanced clozapine-induced dopamine release in the rat striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Halothane; Homovanillic Acid; Kinetics; Male; Rats; Rats, Sprague-Dawley | 2003 |
Chronic administration of haloperidol and olanzapine attenuates ketamine-induced brain metabolic activation.
Topics: Analgesics; Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Brain; Clozapine; Deoxyglucose; Drug Interactions; Haloperidol; Ketamine; Olanzapine; Pirenzepine; Rats; Rats, Sprague-Dawley | 2003 |
Atypical neuroleptic malignant syndrome with clozapine and subsequent haloperidol treatment.
Topics: Adult; Antipsychotic Agents; Clozapine; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome; Schizophrenia | 2003 |
Effects of haloperidol and clozapine on neuropeptide Y-like immunoreactivity in the nucleus accumbens and striatum of rats pretreated with psychostimulants.
Topics: Amphetamine; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Hallucinogens; Haloperidol; Immunohistochemistry; Male; Motor Activity; Neostriatum; Neuropeptide Y; Nucleus Accumbens; Phencyclidine; Rats; Rats, Wistar; Stereotyped Behavior | 2003 |
Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Haloperidol; Male; Membrane Potentials; N-Methylaspartate; Olanzapine; Patch-Clamp Techniques; Phencyclidine; Pirenzepine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2003 |
Effects of clozapine, olanzapine and haloperidol on the microstructure of ingestive behaviour in the rat.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Drinking Behavior; Eating; Fat Emulsions, Intravenous; Feeding Behavior; Haloperidol; Male; Movement; Olanzapine; Pirenzepine; Rats; Time Factors; Tongue | 2003 |
Functional effects of antipsychotic drugs: comparing clozapine with haloperidol.
Topics: Adult; Antipsychotic Agents; Brain; Cerebrovascular Circulation; Clozapine; Female; Haloperidol; Humans; Male; Oxygen Radioisotopes; Tomography, Emission-Computed | 2003 |
Regulation of glutamate carboxypeptidase II function in corticolimbic regions of rat brain by phencyclidine, haloperidol, and clozapine.
Topics: Animals; Blotting, Western; Carboxypeptidases; Clozapine; Dopamine Antagonists; Drug Administration Schedule; Enzyme Inhibitors; Glutamate Carboxypeptidase II; Haloperidol; Hippocampus; Male; Phencyclidine; Prefrontal Cortex; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 2003 |
Cells in midline thalamus, central amygdala, and nucleus accumbens responding specifically to antipsychotic drugs.
Topics: Amygdala; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Diphenhydramine; Haloperidol; Immunohistochemistry; Injections, Intraperitoneal; Lorazepam; Male; Midline Thalamic Nuclei; Nucleus Accumbens; Olanzapine; Pirenzepine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2003 |
Comparison of the effects of antipsychotics on a delayed radial maze task in the rat.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition; Dose-Response Relationship, Drug; Food Deprivation; Haloperidol; Male; Maze Learning; Memory; Olanzapine; Piperazines; Pirenzepine; Rats; Rats, Sprague-Dawley; Risperidone; Thiazoles | 2003 |
Alterations in NMDA receptor subunit levels in the brain regions of rats chronically administered typical or atypical antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Drug Administration Schedule; Haloperidol; Injections, Intraperitoneal; Kinetics; Male; Organ Specificity; Protein Subunits; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2003 |
Comparative analysis of acute and chronic administration of haloperidol and clozapine using [3H] 2-deoxyglucose metabolic mapping.
Topics: Animals; Antipsychotic Agents; Blood Glucose; Brain; Brain Mapping; Clozapine; Deoxyglucose; Drug Administration Schedule; Energy Metabolism; Haloperidol; Long-Term Care; Male; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed | 2003 |
A comparison of drug effects in latent inhibition and the forced swim test differentiates between the typical antipsychotic haloperidol, the atypical antipsychotics clozapine and olanzapine, and the antidepressants imipramine and paroxetine.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Clozapine; Conditioning, Psychological; Haloperidol; Imipramine; Inhibition, Psychological; Male; Models, Animal; Olanzapine; Paroxetine; Pirenzepine; Rats; Rats, Wistar; Swimming | 2003 |
Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Choice Behavior; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Isoxazoles; Male; Memory, Short-Term; Muscarinic Antagonists; Nose; Piperidines; Rats; Reaction Time; Scopolamine; Time Factors | 2003 |
Rehospitalization risk with second-generation and depot antipsychotics.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Data Collection; Delayed-Action Preparations; Female; Fluphenazine; Haloperidol; Humans; Male; Olanzapine; Patient Readmission; Pirenzepine; Risperidone; Schizophrenia; Secondary Prevention; Time Factors; Treatment Outcome | 2003 |
Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Behavior, Animal; Cebus; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesias; Excitatory Amino Acid Antagonists; Female; Haloperidol; Neural Inhibition; Phencyclidine; Reflex, Startle; Schizophrenia | 2003 |
Inhibitory action of clozapine on rat ventral tegmental area dopamine neurons following increased levels of endogenous kynurenic acid.
Topics: Action Potentials; Animals; Butyrates; Clozapine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Haloperidol; Kynurenic Acid; Male; Neural Inhibition; Neurons; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Ventral Tegmental Area | 2003 |
Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia.
Topics: Aging; Amphetamine; Animals; Central Nervous System Stimulants; Clozapine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Antagonists; Drug Interactions; Female; GABA Antagonists; Haloperidol; Hippocampus; In Vitro Techniques; Inhibition, Psychological; Interferon Inducers; Male; Motor Activity; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia | 2003 |
Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; Drug Interactions; ets-Domain Protein Elk-1; Haloperidol; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins; Salicylamides; Transcription Factors | 2003 |
Decreased gene expression of glial and neuronal glutamate transporters after chronic antipsychotic treatment in rat brain.
Topics: Amino Acid Transport System X-AG; Animals; Antipsychotic Agents; Brain; Clozapine; Down-Regulation; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Haloperidol; In Situ Hybridization; Male; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Symporters; Time Factors | 2003 |
Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Brain; Clozapine; Dopamine; Enkephalins; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Haloperidol; Ibotenic Acid; In Situ Hybridization; Isoenzymes; Male; Models, Animal; Neurotensin; Protein Precursors; Rats; Receptors, Dopamine; RNA, Messenger; Schizophrenia; Time Factors | 2003 |
Lack of effect of mood stabilizers or neuroleptics on GSK-3 protein levels and GSK-3 activity.
Topics: Affect; Animals; Antimanic Agents; Antipsychotic Agents; Blotting, Western; Chlorpromazine; Clozapine; Frontal Lobe; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Haloperidol; Lithium; Rats; Rats, Sprague-Dawley; Valproic Acid | 2003 |
Haloperidol and clozapine antagonise amphetamine-induced disruption of latent inhibition of conditioned taste aversion.
Topics: Adrenergic Agents; Amphetamine; Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Rats; Rats, Wistar; Reaction Time; Taste | 2003 |
Effects of NRA0045, a novel potent antagonist at dopamine D4, 5-HT2A, and alpha1 adrenaline receptors, and NRA0160, a selective D4 receptor antagonist, on phencyclidine-induced behavior and glutamate release in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Chromatography, High Pressure Liquid; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Haloperidol; Male; Microdialysis; Motor Activity; Phencyclidine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Stereotyped Behavior; Thiazoles; Time Factors | 2003 |
Different corticostriatal patterns of L-DOPA utilization in patients with untreated schizophrenia and patients treated with classical antipsychotics or clozapine.
Topics: Adult; Antipsychotic Agents; Brain; Clozapine; Dopamine Agents; Haloperidol; Humans; Least-Squares Analysis; Levodopa; Principal Component Analysis; Schizophrenia; Tomography, Emission-Computed | 2003 |
Basal-corticofrontal circuits in schizophrenia and obsessive-compulsive disorder: a controlled, double dissociation study.
Topics: Adult; Antipsychotic Agents; Basal Ganglia; Case-Control Studies; Clozapine; Corpus Striatum; Dissociative Disorders; Female; Frontal Lobe; Haloperidol; Humans; Male; Neural Pathways; Neuropsychological Tests; Obsessive-Compulsive Disorder; Predictive Value of Tests; Prefrontal Cortex; Risperidone; Schizophrenia | 2003 |
Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
Topics: Animals; Catalepsy; Clozapine; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Haloperidol; Male; Protein Binding; Rats; Rats, Sprague-Dawley | 2003 |
Haloperidol and clozapine affect social behaviour in rats postnatally lesioned in the ventral hippocampus.
Topics: Animals; Animals, Newborn; Clozapine; Haloperidol; Hippocampus; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Social Behavior | 2003 |
[Neuroleptics and cognition].
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Middle Aged; Neuropsychological Tests; Olanzapine; Pirenzepine; Product Surveillance, Postmarketing; Risperidone; Schizophrenia; Schizophrenic Psychology | 2003 |
Differential effects of antipsychotics on haloperidol-induced vacuous chewing movements and subcortical gene expression in the rat.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Dyskinesia, Drug-Induced; Gene Expression; Haloperidol; In Situ Hybridization; Injections, Intramuscular; Male; Mastication; Olanzapine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2003 |
Pharmacological actions of a novel and selective dopamine D3 receptor antagonist, KCH-1110.
Topics: Animals; Antipsychotic Agents; Benzamides; Binding, Competitive; Body Temperature; Catalepsy; Cell Line; Clozapine; Cocaine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Humans; Hypothermia; Isoxazoles; Male; Mice; Motor Activity; Prolactin; Psychomotor Performance; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Thiophenes; Tritium | 2003 |
Differential region-specific regulation of central alpha 1-adrenoceptor binding following chronic haloperidol and clozapine administration in the rat.
Topics: Animals; Brain; Clozapine; Haloperidol; Male; Prazosin; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1 | 2004 |
Risk adjustment in studies using administrative data.
Topics: Adult; Antipsychotic Agents; Clozapine; Costs and Cost Analysis; Female; Forecasting; Haloperidol; Health Care Costs; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Quality of Life; Randomized Controlled Trials as Topic; Risk Adjustment; Schizophrenia; Utilization Review | 2003 |
Quetiapine, clozapine, and olanzapine in the treatment of tardive dyskinesia induced by first-generation antipsychotics: a 124-week case report.
Topics: Amphetamine-Related Disorders; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Olanzapine; Quetiapine Fumarate; Schizophrenia, Paranoid | 2003 |
Dynorphinergic GABA neurons are a target of both typical and atypical antipsychotic drugs in the nucleus accumbens shell, central amygdaloid nucleus and thalamic central medial nucleus.
Topics: Acetylcholine; Amygdala; Animals; Antipsychotic Agents; Astrocytes; Clozapine; Dynorphins; Enkephalin, Methionine; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Haloperidol; Intralaminar Thalamic Nuclei; Neural Inhibition; Neurons; Nucleus Accumbens; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2003 |
Antipsychotic drug treatment alters expression of mRNAs encoding lipid metabolism-related proteins.
Topics: Acyltransferases; Animals; Antipsychotic Agents; Apolipoproteins; Apolipoproteins D; Chimerin 1; Clozapine; DNA Primers; Gene Expression Regulation; Haloperidol; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Receptors, Steroid; RNA, Messenger; Transcription, Genetic | 2003 |
Effects of haloperidol and clozapine on Fos expression in the primate striatum.
Topics: Animals; Clozapine; Corpus Striatum; Female; Gene Expression Regulation; Genes, fos; Haloperidol; Macaca fascicularis; Male | 2003 |
Effects of chronic haloperidol and clozapine treatment on AMPA and kainate receptor binding in rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Brain; Clozapine; Dopamine Antagonists; GABA Antagonists; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Serotonin Antagonists; Up-Regulation | 2003 |
Similarities and differences among antipsychotics.
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Dibenzothiazepines; Haloperidol; Humans; Olanzapine; Piperazines; Pirenzepine; Quetiapine Fumarate; Quinolones; Risperidone; Schizophrenia; Thiazoles | 2003 |
Treatment of rats with antipsychotic drugs: lack of an effect on brain N-acetyl aspartate levels.
Topics: Animals; Antipsychotic Agents; Aspartic Acid; Brain; Brain Mapping; Cell Survival; Chromatography, High Pressure Liquid; Clozapine; Haloperidol; Magnetic Resonance Spectroscopy; Male; Neurons; Rats; Rats, Sprague-Dawley | 2004 |
Hippocampal volume and cell proliferation after acute and chronic clozapine or haloperidol treatment.
Topics: Animals; Cell Division; Clozapine; Haloperidol; Hippocampus; Male; Rats; Rats, Sprague-Dawley | 2004 |
Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Butyrophenones; Clozapine; Discrimination, Psychological; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Fluorobenzenes; Generalization, Stimulus; Haloperidol; Male; Muscarinic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Trihexyphenidyl | 2004 |
Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effects.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Gait Disorders, Neurologic; Haloperidol; Inhibition, Psychological; Male; Neurotensin; Rats; Rats, Brattleboro; Rats, Long-Evans; Reflex, Startle; Schizophrenia; Species Specificity | 2004 |
Effects of dopaminergic drugs on the mast cell degranulation and nitric oxide generation in RAW 264.7 cells.
Topics: Animals; beta-N-Acetylhexosaminidases; Bromocriptine; Cell Degranulation; Cell Line, Tumor; Clozapine; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Precursors; Haloperidol; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Mast Cells; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Phospholipase C gamma; Protein-Tyrosine Kinases; Quercetin; Receptors, IgE; Signal Transduction; Syk Kinase; Tetrahydronaphthalenes; Type C Phospholipases | 2004 |
Nicotine-antipsychotic drug interactions and attentional performance in female rats.
Topics: Animals; Antipsychotic Agents; Attention; Central Nervous System Stimulants; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Female; Haloperidol; Nicotine; Photic Stimulation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Risperidone | 2004 |
Apomorphine-induced disruption of prepulse inhibition that can be normalised by systemic haloperidol is insensitive to clozapine pretreatment.
Topics: Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Clozapine; Drug Interactions; Haloperidol; Male; Mice; Mice, Inbred C57BL; Reflex, Startle | 2004 |
Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Bromodeoxyuridine; Cell Count; Cell Division; Cell Survival; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glial Fibrillary Acidic Protein; Haloperidol; Hippocampus; Immunohistochemistry; Male; Phenotype; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley | 2004 |
Chronic treatment with atypical neuroleptics induces striosomal FosB/DeltaFosB expression in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Caudate Nucleus; Clozapine; Drug Administration Schedule; Haloperidol; Male; Movement Disorders; Neural Pathways; Nucleus Accumbens; Olanzapine; Peptide Fragments; Proto-Oncogene Proteins c-fos; Putamen; Rats; Rats, Wistar; Tissue Distribution; Transcription Factors | 2004 |
Inhibition of stress-induced dopamine output in the rat prefrontal cortex by chronic treatment with olanzapine.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Dopamine; Down-Regulation; Drug Administration Schedule; Electroshock; Haloperidol; Male; Neurons; Olanzapine; Prefrontal Cortex; Random Allocation; Rats; Rats, Sprague-Dawley; Stress, Psychological | 2004 |
Differential effects of long-term treatment with clozapine or haloperidol on GABAA receptor binding and GAD67 expression.
Topics: Animals; Antipsychotic Agents; Binding Sites; Clozapine; Disease Models, Animal; Drug Administration Schedule; Glutamate Decarboxylase; Haloperidol; Isoenzymes; Limbic System; Male; Parietal Lobe; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Complementary; Schizophrenia; Temporal Lobe; Up-Regulation | 2004 |
Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Chlorpromazine; Clozapine; Gene Expression Regulation; Haloperidol; Hippocampus; In Situ Hybridization; Male; Microfilament Proteins; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurites; Olanzapine; Rats; Rats, Sprague-Dawley; Risperidone; RNA, Messenger; Tissue Distribution | 2004 |
Clozapine and olanzapine, but not haloperidol, reverse cold-induced and lipopolysaccharide-induced cutaneous vasoconstriction.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Body Temperature; Clozapine; Cold Temperature; Dose-Response Relationship, Drug; Ear, External; Haloperidol; Laser-Doppler Flowmetry; Lipopolysaccharides; Olanzapine; Rabbits; Regional Blood Flow; Skin; Vasoconstriction | 2004 |
Clozapine maintenance therapy in schizophrenia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Long-Term Care; Male; Middle Aged; Patient Compliance; Psychiatric Status Rating Scales; Retrospective Studies; Risk Assessment; Schizophrenia; Schizophrenic Psychology | 2004 |
COMT158 polymorphism and hostility.
Topics: Antipsychotic Agents; Benzodiazepines; Catechol O-Methyltransferase; Clozapine; Genotype; Haloperidol; Hostility; Humans; Methionine; Olanzapine; Polymorphism, Genetic; Risperidone; Schizophrenia; Schizophrenic Psychology; Valine | 2004 |
The use of stereological counting methods to assess immediate early gene immunoreactivity.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Cell Count; Clozapine; Corpus Striatum; Diagnostic Imaging; Gene Expression Regulation; Genes, Immediate-Early; Haloperidol; Immunohistochemistry; Neurons; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Stereotaxic Techniques | 2004 |
Cannabidiol increases Fos expression in the nucleus accumbens but not in the dorsal striatum.
Topics: Animals; Cannabidiol; Clozapine; Haloperidol; Injections, Intraperitoneal; Male; Neostriatum; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar | 2004 |
Nicotine blocks apomorphine-induced disruption of prepulse inhibition of the acoustic startle in rats: possible involvement of central nicotinic alpha7 receptors.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apomorphine; Central Nervous System; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phencyclidine; Rats; Rats, Wistar; Receptors, Nicotinic; Reflex, Startle | 2004 |
The influence of repeated administration of clozapine and haloperidol on the effects of the activation of 5-HT(1A), 5-HT(2) and 5-HT(4) receptors in rat frontal cortex.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Clozapine; Excitatory Postsynaptic Potentials; Frontal Lobe; Haloperidol; Male; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT4; Serotonin Receptor Agonists; Time Factors | 2004 |
Effects of typical and atypical antipsychotic drugs on maternal behavior in postpartum female rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dibenzothiazepines; Female; Haloperidol; Maternal Behavior; Postpartum Period; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Risperidone | 2004 |
Covariate adjustment in clinical trials with non-ignorable missing data and non-compliance.
Topics: Antipsychotic Agents; Clozapine; Empirical Research; Haloperidol; Humans; Outcome Assessment, Health Care; Patient Compliance; Randomized Controlled Trials as Topic; Schizophrenia | 2004 |
Haloperidol- and clozapine-induced oxidative stress in the rat brain.
Topics: Animals; Antioxidants; Antipsychotic Agents; Brain Chemistry; Catalase; Cerebral Cortex; Clozapine; Haloperidol; Hippocampus; Male; Mitochondria; Neostriatum; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Thiobarbituric Acid Reactive Substances | 2004 |
Evaluation of the motor initiation hypothesis of APD-induced conditioned avoidance decreases.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Chlordiazepoxide; Clozapine; Haloperidol; Male; Motor Activity; Rats; Rats, Sprague-Dawley | 2004 |
Endogenous kynurenic acid disrupts prepulse inhibition.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Butyrates; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Radiation; Drug Interactions; Haloperidol; Kynurenic Acid; Kynurenine; Male; Neural Inhibition; Probenecid; Rats; Reflex, Startle | 2004 |
Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2005 |
Effects of psychotomimetic and antipsychotic agents on neocortical and striatal concentrations of various amino acids in the rat.
Topics: Amino Acids; Animals; Antipsychotic Agents; Brain Chemistry; Chromatography, High Pressure Liquid; Clozapine; Corpus Striatum; Drug Interactions; Haloperidol; Male; Methamphetamine; Mixed Function Oxygenases; Neocortex; Rats; Rats, Wistar; Time Factors | 2004 |
Clozapine increases both acetylcholine and dopamine release in rat ventral hippocampus: role of 5-HT1A receptor agonism.
Topics: Acetylcholine; Animals; Clozapine; Dopamine; Haloperidol; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists | 2004 |
Cerebral metabolic changes induced by clozapine in schizophrenia and related to clinical improvement.
Topics: Adult; Antipsychotic Agents; Brain; Clozapine; Female; Haloperidol; Humans; Male; Positron-Emission Tomography; Schizophrenia | 2005 |
Effects of typical and atypical antipsychotics on human glycine transporters.
Topics: Amino Acid Transport Systems, Neutral; Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chloride Channels; Choriocarcinoma; Clozapine; Female; Glycine; Glycine Plasma Membrane Transport Proteins; Haloperidol; Humans; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Olanzapine; Rats; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenia; Sodium Channels; Synapses; Uterine Neoplasms | 2004 |
Clozapine reduces alcohol drinking in Syrian golden hamsters.
Topics: Alcohol Drinking; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cricetinae; Haloperidol; Injections, Subcutaneous; Male; Mesocricetus | 2004 |
Differential effects of long-term treatment with clozapine or haloperidol on GABA transporter expression.
Topics: Amino Acid Transport Systems; Animals; Antipsychotic Agents; Brain; Clozapine; Drug Administration Schedule; GABA Plasma Membrane Transport Proteins; Haloperidol; In Situ Hybridization; Male; Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; RNA, Complementary; Time Factors; Vesicular Inhibitory Amino Acid Transport Proteins; Vesicular Transport Proteins; Water | 2004 |
[Expectations and developments in atypical antipsychotics].
Topics: Antipsychotic Agents; Aripiprazole; Benzodiazepines; Body Mass Index; Clozapine; Diabetes Complications; Haloperidol; Humans; Obesity; Olanzapine; Piperazines; Quinolones; Risk Factors; Schizophrenia; Weight Gain | 2004 |
Stable deficits in gray matter volumes following a first episode of schizophrenia.
Topics: Adult; Antipsychotic Agents; Cerebral Cortex; Clozapine; Haloperidol; Humans; Schizophrenia | 2004 |
Haloperidol and clozapine, but not olanzapine, induces oxidative stress in rat brain.
Topics: Animals; Benzodiazepines; Brain; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Male; Olanzapine; Oxidative Stress; Rats; Rats, Wistar | 2004 |
Chronic haloperidol or clozapine treatment does not alter parvalbumin immunoreactivity in the rat frontal cortex or hippocampus.
Topics: Animals; Antipsychotic Agents; Cell Size; Clozapine; Frontal Lobe; Haloperidol; Hippocampus; Image Processing, Computer-Assisted; Immunohistochemistry; Male; Neurons; Parvalbumins; Rats; Rats, Sprague-Dawley | 2005 |
Effects of l-stepholidine on forebrain Fos expression: comparison with clozapine and haloperidol.
Topics: Animals; Antipsychotic Agents; Berberine; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Immunohistochemistry; Neostriatum; Nucleus Accumbens; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Septal Nuclei | 2005 |
Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors.
Topics: Animals; Cell Count; Clozapine; Corpus Striatum; Dopamine Antagonists; Drug Administration Schedule; GABA Antagonists; Gene Expression Regulation; Haloperidol; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Proto-Oncogene Proteins c-fos; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2004 |
Effects of clozapine, olanzapine and haloperidol on ethanol-induced ascorbic acid release in mouse striatum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Ascorbic Acid; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Clozapine; Dialysis; Ethanol; Haloperidol; Male; Mice; Neostriatum; Olanzapine; Serotonin Receptor Agonists | 2005 |
Neuroleptic malignant syndrome and clozapine withdrawal at the same time?
Topics: Adult; Antipsychotic Agents; Clozapine; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome; Psychomotor Agitation; Substance Withdrawal Syndrome; Treatment Refusal | 2005 |
Investigation of the effects of lamotrigine and clozapine in improving reversal-learning impairments induced by acute phencyclidine and D-amphetamine in the rat.
Topics: Animals; Antimanic Agents; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Hallucinogens; Haloperidol; Lamotrigine; Learning Disabilities; Phencyclidine; Rats; Reversal Learning; Triazines | 2005 |
Impairing effects of chronic haloperidol and clozapine treatment on recognition memory: possible relation to oxidative stress.
Topics: Animals; Clozapine; Haloperidol; Injections, Intraperitoneal; Memory, Short-Term; Oxidative Stress; Rats; Recognition, Psychology | 2005 |
The impact of neuroleptic medication on seizure threshold and duration in electroconvulsive therapy.
Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Brain; Clopenthixol; Clozapine; Dibenzothiazepines; Electric Impedance; Electroconvulsive Therapy; Electroencephalography; Electromyography; Female; Fluphenazine; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Quetiapine Fumarate; Risperidone; Seizures; Sulpiride | 2004 |
Clozapine-induced dopamine release in the medial prefrontal cortex is augmented by a moderate concentration of locally administered tyrosine but attenuated by high tyrosine concentrations or by tyrosine depletion.
Topics: Amino Acids; Animals; Antipsychotic Agents; Clozapine; Dopamine; Extracellular Space; Haloperidol; Male; Microdialysis; Neostriatum; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Tyrosine | 2005 |
Decreased expression of a 40-kDa catecholamine-regulated protein in the ventral striatum of schizophrenic brain specimens from the Stanley Foundation Neuropathology Consortium.
Topics: Adult; Aged; Antipsychotic Agents; Basal Ganglia; Clozapine; Diagnostic and Statistical Manual of Mental Disorders; Female; Haloperidol; HSP70 Heat-Shock Proteins; Humans; Male; Middle Aged; Nerve Tissue Proteins; Schizophrenia | 2005 |
Effects of haloperidol and clozapine on glutamate release from nerve terminals isolated from rat prefrontal cortex.
Topics: Animals; Clozapine; Dose-Response Relationship, Drug; Glutamic Acid; Haloperidol; Male; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 2005 |
Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms.
Topics: Action Potentials; Analysis of Variance; Animals; Antipsychotic Agents; Butyrates; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Kynurenic Acid; Locus Coeruleus; Male; Neurons; Norepinephrine; Quinolones; Rats; Rats, Sprague-Dawley | 2005 |
Benztropine equivalents for antimuscarinic medication.
Topics: Antipsychotic Agents; Benztropine; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Muscarinic Antagonists; Therapeutic Equivalency | 2005 |
A putative animal model of the "prodromal" state of schizophrenia.
Topics: Amphetamine; Analysis of Variance; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Benzazepines; Central Nervous System Stimulants; Clozapine; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Haloperidol; Inhibition, Psychological; Male; Motor Activity; Neural Inhibition; Random Allocation; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex, Startle; Schizophrenia; Substance Withdrawal Syndrome; Time Factors | 2005 |
SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit.
Topics: Age Factors; Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Clozapine; Dextroamphetamine; Dioxanes; Discrimination, Psychological; Disease Models, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Imipramine; Injections, Intraperitoneal; Male; Phencyclidine; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Recognition, Psychology; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Social Behavior; Tacrine; Tropanes | 2005 |
Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Cannabidiol; Clozapine; Dextroamphetamine; Haloperidol; Injections, Intraperitoneal; Ketamine; Locomotion; Male; Mice; Sympathomimetics; Time Factors | 2005 |
A case of delayed galactorrhoea as an adverse event of overlapping haloperidol and clozapine administration.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Interactions; Female; Galactorrhea; Haloperidol; Humans; Psychotic Disorders | 2005 |
Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Piperazines; Piperidines; Pyridines; Quinolones; Receptor, Serotonin, 5-HT1A; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Thiazoles | 2005 |
Abnormally persistent latent inhibition induced by lesions to the nucleus accumbens core, basolateral amygdala and orbitofrontal cortex is reversed by clozapine but not by haloperidol.
Topics: Amygdala; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Drinking Behavior; Haloperidol; Male; Nerve Net; Neural Inhibition; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Serotonin; Schizophrenia | 2006 |
Behaviorally timid rats respond differentially to conventional and atypical neuroleptics.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Female; Haloperidol; Ovariectomy; Random Allocation; Rats; Rats, Long-Evans; Social Behavior; Sulpiride; Time Factors | 2005 |
The dopaminergic stabilizers (-)-OSU6162 and ACR16 reverse (+)-MK-801-induced social withdrawal in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Male; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Schizophrenic Psychology; Social Behavior | 2005 |
Possible malignant neuroleptic syndrome that associated with hypothyroidism.
Topics: Adrenal Insufficiency; Antipsychotic Agents; Body Temperature; Clozapine; Female; Haloperidol; Humans; Hyponatremia; Hypothyroidism; Middle Aged; Muscle Rigidity; Neuroleptic Malignant Syndrome; Schizophrenia | 2005 |
The inhibitory effect of neurotensin on synaptosomal membrane Na+, K+-ATPase is altered by antipsychotic administration.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Cerebral Cortex; Clozapine; Haloperidol; Male; Neurotensin; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Synaptic Membranes; Synaptosomes | 2005 |
Kappa opioid receptor activation disrupts prepulse inhibition of the acoustic startle in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acoustic Stimulation; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Inhibition, Psychological; Male; Naltrexone; Narcotic Antagonists; Rats; Receptors, Opioid, kappa; Reflex, Startle | 2005 |
Increased serum S100B in elderly, chronic schizophrenic patients: negative correlation with deficit symptoms.
Topics: Aged; Antipsychotic Agents; Chronic Disease; Clozapine; Cognition Disorders; Depressive Disorder, Major; Female; Haloperidol; Humans; Male; Middle Aged; Nerve Growth Factors; Neuropsychological Tests; Psychological Tests; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index | 2005 |
The effect of chronic co-administration of fluvoxamine and haloperidol compared to clozapine on the GABA system in the rat frontal cortex.
Topics: Animals; Clozapine; Drug Therapy, Combination; Fluvoxamine; Frontal Lobe; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Haloperidol; Isoenzymes; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2006 |
Atypical antipsychotics produce within-session decrements on self-stimulation of the rat medial prefrontal cortex.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Prefrontal Cortex; Rats; Rats, Wistar; Risperidone; Self Stimulation | 2005 |
Clozapine increases cutaneous blood flow and reduces sympathetic cutaneous vasomotor alerting responses (SCVARs) in rats: comparison with effects of haloperidol.
Topics: Animals; Antipsychotic Agents; Arousal; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Injections, Subcutaneous; Laser-Doppler Flowmetry; Lipopolysaccharides; N-Methyl-3,4-methylenedioxyamphetamine; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Skin; Skin Temperature; Sympathetic Nervous System; Vasoconstriction; Vasomotor System | 2005 |
Neurotensin-deficient mice have deficits in prepulse inhibition: restoration by clozapine but not haloperidol, olanzapine, or quetiapine.
Topics: Amphetamine; Animals; Antipsychotic Agents; Benzodiazepines; Body Weight; Clozapine; Dibenzothiazepines; Female; Haloperidol; Male; Mice; Mice, Inbred C57BL; Neurotensin; Olanzapine; Quetiapine Fumarate; Reflex; Reflex, Startle | 2005 |
Pharmacokinetic-pharmacodynamic analysis of antipsychotics-induced extrapyramidal symptoms based on receptor occupancy theory incorporating endogenous dopamine release.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Controlled Clinical Trials as Topic; Dibenzothiazepines; Haloperidol; Humans; Olanzapine; Piperazines; Quetiapine Fumarate; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Risperidone; Schizophrenia; Thiazoles | 2005 |
Differential effects of clozapine and haloperidol on interval timing in the supraseconds range.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Haloperidol; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin; Time Perception | 2005 |
Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells.
Topics: Actins; Analysis of Variance; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Blood Cells; Clozapine; Glucose Transporter Type 3; Glucose Transporter Type 4; Glucose Transporter Type 5; Haloperidol; Humans; Mianserin; Mirtazapine; Olanzapine; RNA, Messenger; U937 Cells | 2006 |
Effects of novel antipsychotics with mixed D(2) antagonist/5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Dioxanes; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Interpersonal Relations; Male; Phencyclidine; Piperazines; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Remoxipride; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Tropanes | 2005 |
Neurologic soft signs in schizophrenic patients treated with conventional and atypical antipsychotics.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Haloperidol; Humans; Male; Nervous System Diseases; Neuropsychological Tests; Olanzapine; Risperidone; Schizophrenia; Severity of Illness Index | 2005 |
Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?
Topics: Antipsychotic Agents; Cell Line, Tumor; Cholesterol; Clozapine; Fatty Acid Synthases; Fatty Acids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Haloperidol; Humans; Hydroxymethylglutaryl-CoA Synthase; Oligonucleotide Array Sequence Analysis; RNA; Schizophrenia; Time Factors; Up-Regulation | 2005 |
Novel oral drug administration in an animal model of neuroleptic therapy.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Behavior, Animal; Body Weight; Brain; Clozapine; Diazepam; Disease Models, Animal; Dyskinesia, Drug-Induced; Grooming; Haloperidol; Male; Mastication; Motivation; Motor Activity; Rats; Rats, Sprague-Dawley; Reaction Time | 2005 |
Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chlorpromazine; Chromones; Clozapine; Dibenzothiazepines; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluphenazine; Haloperidol; Humans; Morpholines; Nerve Growth Factor; Neurites; Olanzapine; PC12 Cells; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quetiapine Fumarate; Rats | 2005 |
Postnatal iron-induced motor behaviour alterations following chronic neuroleptic administration in mice.
Topics: Animals; Antipsychotic Agents; Apomorphine; Basal Ganglia; Clozapine; Dopamine Agonists; Drug Interactions; Female; Haloperidol; Hyperkinesis; Iron; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pregnancy | 2006 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition Disorders; Exploratory Behavior; Hallucinogens; Haloperidol; Male; Mice; Mice, Inbred ICR; Phencyclidine; Time Factors | 2005 |
Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Humans; Mice; NIH 3T3 Cells; Pergolide; Plasmids; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; RGS Proteins; Transfection | 2005 |
Use of LC/MS to assess brain tracer distribution in preclinical, in vivo receptor occupancy studies: dopamine D2, serotonin 2A and NK-1 receptors as examples.
Topics: Animals; Antipsychotic Agents; Aprepitant; Benzodiazepines; Brain; Chromatography, High Pressure Liquid; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Evaluation, Preclinical; Fluorobenzenes; Gerbillinae; Haloperidol; Male; Mass Spectrometry; Morpholines; Neurokinin-1 Receptor Antagonists; Olanzapine; Piperidines; Raclopride; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Neurokinin-1; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Tetrazoles | 2005 |
The effects of antipsychotics on beta-catenin, glycogen synthase kinase-3 and dishevelled in the ventral midbrain of rats.
Topics: Adaptor Proteins, Signal Transducing; Amphetamine; Animals; Antipsychotic Agents; Benzazepines; beta Catenin; Blotting, Western; Central Nervous System Stimulants; Clozapine; Cytoskeletal Proteins; Dishevelled Proteins; Dopamine Agonists; Female; Glycogen Synthase Kinase 3; Haloperidol; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Male; Mesencephalon; Phosphoproteins; Quinpirole; Rats; Rats, Sprague-Dawley; Risperidone; Signal Transduction; Trans-Activators; Wnt Proteins; Wnt1 Protein | 2005 |
Neuroleptic malignant syndrome precipitated by haloperidol following clozapine discontinuation.
Topics: Adult; Anti-Anxiety Agents; Antiparkinson Agents; Antipsychotic Agents; Bromocriptine; Clozapine; Creatine Kinase; Dose-Response Relationship, Drug; Electroconvulsive Therapy; Haloperidol; Humans; Lorazepam; Male; Neuroleptic Malignant Syndrome; Psychotic Disorders; Schizophrenia; Substance Withdrawal Syndrome | 2005 |
Dissimilar effects of subchronic clozapine and haloperidol on operant lever pressing in C57BL/6J, BALB/cJ, and LP/J mice.
Topics: Animals; Antipsychotic Agents; Clozapine; Conditioning, Operant; Drug Tolerance; Food; Haloperidol; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Species Specificity | 2005 |
Clozapine and haloperidol differentially alter the constitutive activity of central serotonin2C receptors in vivo.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Brain; Chromatography, High Pressure Liquid; Clozapine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Ethylamines; Haloperidol; Indoles; Male; Microdialysis; Nerve Net; Nucleus Accumbens; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists; Substantia Nigra | 2006 |
Effects of a typical and an atypical antipsychotic on the disruption of prepulse inhibition caused by corticotropin-releasing factor and by rat strain.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Haloperidol; Hormones; Injections, Intraventricular; Male; Neural Inhibition; Rats; Rats, Inbred BN; Rats, Inbred WKY; Reflex, Startle | 2005 |
Actions of antipsychotic drugs on pancreatic beta-cell function: contrasting effects of clozapine and haloperidol.
Topics: Animals; Antipsychotic Agents; Cells, Cultured; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Insulin; Insulin Secretion; Insulin-Secreting Cells; Membrane Potentials; Potassium Channels; Rats; Rats, Sprague-Dawley; Secretory Rate | 2005 |
Weight gain as a prognostic indicator of therapeutic improvement during acute treatment of schizophrenia with placebo or active antipsychotic.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Linear Models; Male; Meta-Analysis as Topic; Middle Aged; Olanzapine; Placebo Effect; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Risperidone; Schizophrenia; Schizophrenic Psychology; Time Factors; Treatment Outcome; Weight Gain | 2005 |
Modulation of striatal dopamine release in vitro by agonists of the glycineB site of NMDA receptors; interaction with antipsychotics.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Haloperidol; Magnesium; Male; N-Methylaspartate; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Salicylamides | 2005 |
Clozapine and olanzapine, but not haloperidol, suppress serotonin efflux in the medial prefrontal cortex elicited by phencyclidine and ketamine.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzodiazepines; Brain Chemistry; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Ketamine; Male; Microdialysis; Olanzapine; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar; Serotonin; Time Factors | 2006 |
Models of treatment with antipsychotics of the schizophrenic patients.
Topics: Adult; Aged; Antipsychotic Agents; Bosnia and Herzegovina; Clozapine; Drug Utilization; Female; Haloperidol; Hospitals, University; Humans; Male; Middle Aged; Prospective Studies; Psychotropic Drugs; Schizophrenia; Sex Characteristics | 2005 |
Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor function.
Topics: Acoustic Stimulation; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Female; Genotype; Haloperidol; Hippocampus; Histamine Antagonists; Imipramine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Prefrontal Cortex; Quetiapine Fumarate; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Sex Characteristics | 2006 |
[Treatment resistant schizophrenia, residual subtype: symptom improvement after additional treatment with amisulpride].
Topics: Adult; Amisulpride; Antipsychotic Agents; Benzodiazepines; Clozapine; Commitment of Mentally Ill; Drug Resistance; Drug Therapy, Combination; Follow-Up Studies; Haloperidol; Homicide; Humans; Insanity Defense; Male; Olanzapine; Prisoners; Schizophrenia, Paranoid; Sulpiride; Treatment Outcome | 2006 |
Clozapine, but not haloperidol, increases neuropeptide Y neuronal expression in the rat hypothalamus.
Topics: Animals; Antipsychotic Agents; Arcuate Nucleus of Hypothalamus; Clozapine; Haloperidol; Hippocampus; Immunohistochemistry; Male; Neurons; Neuropeptide Y; Rats; Rats, Sprague-Dawley | 2006 |
Effects of haloperidol and clozapine on sensorimotor gating deficits induced by 5-hydroxytryptamine depletion in the brain.
Topics: 5,7-Dihydroxytryptamine; Acoustic Stimulation; Animals; Antipsychotic Agents; Brain Chemistry; Clozapine; Haloperidol; Male; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reflex, Startle; Serotonin | 2006 |
Sub-chronic antipsychotic drug treatment does not alter brain phospholipid fatty acid composition in rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Brain; Chromatography, High Pressure Liquid; Clozapine; Fatty Acids; Haloperidol; Male; Phospholipids; Rats; Rats, Sprague-Dawley | 2006 |
Antipsychotic-induced alterations in D2 dopamine receptor interacting proteins within the cortex.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Calcium-Binding Proteins; Cerebral Cortex; Clozapine; Cytoskeletal Proteins; Gene Expression; Haloperidol; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuronal Calcium-Sensor Proteins; Neuropeptides; Receptors, Dopamine D2 | 2006 |
Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain.
Topics: Animals; Antipsychotic Agents; Brain; Chromatography, High Pressure Liquid; Clozapine; Haloperidol; Kynurenic Acid; Kynurenine; Male; Microdialysis; Raclopride; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Microarray analysis reveals distinct gene expression patterns in the mouse cortex following chronic neuroleptic and stimulant treatment: implications for body weight changes.
Topics: Animals; Antipsychotic Agents; Appetite Regulation; Central Nervous System Stimulants; Cerebral Cortex; Clozapine; Gene Expression; Haloperidol; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Phenylpropanolamine; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Selective increases in the cytokine, TNFalpha, in the prefrontal cortex of PCP-treated rats and human schizophrenic subjects: influence of antipsychotic drugs.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Clozapine; Cytokines; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Gene Expression; Haloperidol; Humans; Immunohistochemistry; Male; Middle Aged; Phencyclidine; Prefrontal Cortex; Rats; Rats, Long-Evans; Reverse Transcriptase Polymerase Chain Reaction; RNA; Schizophrenia; Tumor Necrosis Factor-alpha | 2006 |
Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia.
Topics: Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Clozapine; COP9 Signalosome Complex; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Guanine Nucleotide Exchange Factors; Haloperidol; Heat-Shock Proteins; Humans; Image Processing, Computer-Assisted; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Male; Membrane Transport Proteins; Middle Aged; Rats; Rats, Sprague-Dawley; Rho Guanine Nucleotide Exchange Factors; RNA, Messenger; Schizophrenia; Thalamus; Transcription, Genetic | 2006 |
Dopamine D3 receptor modulation of dopamine efflux in the rat nucleus accumbens.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Haloperidol; Male; Nitriles; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Sulpiride; Tetrahydroisoquinolines; Tetrahydronaphthalenes | 2006 |
Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from C6 glioma cells.
Topics: Animals; Antipsychotic Agents; Cell Line, Tumor; Clozapine; Dibenzothiazepines; Enzyme-Linked Immunosorbent Assay; Glial Cell Line-Derived Neurotrophic Factor; Glioma; Haloperidol; Hippocampus; Quetiapine Fumarate; Rats | 2006 |
Role of nigral NFkappaB p50 and p65 subunit expression in haloperidol-induced neurotoxicity and stereotyped behavior in rats.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Blotting, Western; Clozapine; Dopamine Plasma Membrane Transport Proteins; Gene Expression; Haloperidol; Male; Neurotoxicity Syndromes; NF-kappa B p52 Subunit; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra; Transcription Factor RelA | 2006 |
Haloperidol and atypical antipsychotics share a same action of decreasing P75(NTR) mRNA levels in PC12 cells.
Topics: Animals; Antipsychotic Agents; Cell Survival; Clozapine; Dibenzothiazepines; Dose-Response Relationship, Drug; Down-Regulation; Gene Expression; Haloperidol; PC12 Cells; Quetiapine Fumarate; Rats; Receptor, Nerve Growth Factor; Risperidone; RNA, Messenger; Time Factors | 2006 |
Neuropeptide Y mRNA expression levels following chronic olanzapine, clozapine and haloperidol administration in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Female; Haloperidol; In Situ Hybridization; Mice; Neuropeptide Y; Olanzapine; Rats; RNA, Messenger | 2006 |
Translocation of AIF in the human and rat striatum following protracted haloperidol, but not clozapine treatment.
Topics: Animals; Antipsychotic Agents; Apoptosis; Apoptosis Inducing Factor; Case-Control Studies; Cell Line, Tumor; Cell Nucleus; Cell Survival; Clozapine; Corpus Striatum; Haloperidol; Humans; Immunohistochemistry; Male; Mitochondria; Neuroblastoma; Rats; Rats, Sprague-Dawley | 2006 |
Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Benzoxazoles; Binding, Competitive; Cell Line; Clozapine; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Male; Piperazines; Prolactin; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Spodoptera; Sulfur Radioisotopes; Tropanes | 2006 |
Long-term antipsychotic treatments and crossover studies in rats: differential effects of typical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brain.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chlorpromazine; Clozapine; Cross-Over Studies; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Haloperidol; Lipid Peroxidation; Male; Membrane Lipids; Olanzapine; Rats; Rats, Wistar; Risperidone; Schizophrenia; Superoxide Dismutase | 2007 |
Clozapine but not haloperidol suppresses the changes in the levels of neuropeptides in MK-801-treated rat brain regions.
Topics: Animals; Brain; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Haloperidol; Male; Neuropeptides; Rats; Rats, Wistar; Sex Factors | 2006 |
Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.
Topics: Animals; Anisoles; Antipsychotic Agents; Benzazepines; Butaclamol; Caspase Inhibitors; Cell Death; Cells, Cultured; Chlorpromazine; Clozapine; Domperidone; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Ginkgo biloba; Haloperidol; Hippocampus; Indans; Isoxazoles; Neurons; Neuroprotective Agents; Peptides; Piperidines; Plant Extracts; Propylamines; Raclopride; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Remoxipride; Risperidone; Sulpiride | 2006 |
Brain lipid composition in postnatal iron-induced motor behavior alterations following chronic neuroleptic administration in mice.
Topics: Animals; Antipsychotic Agents; Brain; Brain Chemistry; Clozapine; Dietary Supplements; Drug Administration Schedule; Female; Haloperidol; Iron; Membrane Lipids; Mice; Mice, Inbred C57BL; Motor Activity; Phosphatidylcholines; Pregnancy; Sphingomyelins | 2006 |
Antipsychotic pathway genes with expression altered in opposite direction by antipsychotics and amphetamine.
Topics: Amphetamine; Animals; Antipsychotic Agents; Brain; Brain Chemistry; Chromosome Mapping; Clozapine; Dopamine Agents; Down-Regulation; Gene Expression Regulation; Haloperidol; Male; Molecular Sequence Data; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schizophrenia; Up-Regulation | 2006 |
Atypical antipsychotics and pituitary tumors: a pharmacovigilance study.
Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Amenorrhea; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Child; Clozapine; Dibenzothiazepines; Female; Galactorrhea; Gynecomastia; Haloperidol; Humans; Hyperprolactinemia; Male; Olanzapine; Piperazines; Pituitary Neoplasms; Quetiapine Fumarate; Quinolones; Retrospective Studies; Risperidone; Sex Factors; Thiazoles; United States; United States Food and Drug Administration | 2006 |
Typical and atypical antipsychotic drugs target dopamine and cyclic AMP-regulated phosphoprotein, 32 kDa and neurotensin-containing neurons, but not GABAergic interneurons in the shell of nucleus accumbens of ventral striatum.
Topics: Animals; Antipsychotic Agents; Calbindin 1; Calbindin 2; Calbindins; Cell Count; Clozapine; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Fluorescent Antibody Technique; Gene Expression; Haloperidol; Male; Neurons; Neurotensin; Nucleus Accumbens; Parvalbumins; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G | 2006 |
Blockade of 5-HT2a receptors reduces haloperidol-induced attenuation of reward.
Topics: Analysis of Variance; Animals; Behavior, Animal; Body Temperature Regulation; Clozapine; Differential Threshold; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Extinction, Psychological; Fluorobenzenes; Haloperidol; Male; Piperidines; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Serotonin 5-HT2 Receptor Antagonists | 2007 |
Region specific regulation of NR1 in rhesus monkeys following chronic antipsychotic drug administration.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Brain; Clozapine; Gene Expression; Haloperidol; Macaca mulatta; Receptors, N-Methyl-D-Aspartate | 2006 |
Effects of clozapine, olanzapine and haloperidol on nitric oxide production by lipopolysaccharide-activated N9 cells.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Cell Line; Cell Survival; Clozapine; Haloperidol; Lipopolysaccharides; Mice; Microglia; Nitric Oxide; Nitrites; Olanzapine | 2006 |
Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein.
Topics: Animals; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepines; Chlorpromazine; Clozapine; Cyclosporins; Dibenzothiazepines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Flow Cytometry; Fluorescent Dyes; Haloperidol; Isoxazoles; Kidney; Liver; LLC-PK1 Cells; Olanzapine; Paliperidone Palmitate; Pyrimidines; Quetiapine Fumarate; Rhodamine 123; Risperidone; Swine; Transfection | 2006 |
Differential effects of haloperidol, clozapine and olanzapine on learning and memory functions in mice.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Clozapine; Haloperidol; Learning; Maze Learning; Memory; Mice; Models, Animal; Motor Activity; Olanzapine; Swimming | 2006 |
Clozapine and haloperidol differentially regulate dendritic spine formation and synaptogenesis in rat hippocampal neurons.
Topics: Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Antipsychotic Agents; Blotting, Western; Cells, Cultured; Clozapine; Dendritic Spines; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Hippocampus; Immunohistochemistry; Microfilament Proteins; Nerve Tissue Proteins; Neurons; Rats; Synapses; Synapsins | 2006 |
Atypical antipsychotics, tardive dyskinesia, and D(2) receptors.
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Dyskinesia, Drug-Induced; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Receptors, Dopamine D2; Schizophrenia; Up-Regulation | 2006 |
Differently lasting effects of prenatal and postnatal chronic clozapine/haloperidol on activity and memory in mouse offspring.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Body Weight; Central Nervous System; Clozapine; Female; Haloperidol; Male; Maternal Exposure; Maze Learning; Memory; Mice | 2006 |
Effects of (-)stepholidine in animal models for schizophrenia.
Topics: Animals; Antipsychotic Agents; Berberine; Clozapine; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Motor Activity; Plants, Medicinal; Rats; Rats, Wistar; Receptors, Dopamine D1; Schizophrenia; Stephania | 2006 |
Comparing sertindole to other new generation antipsychotics on preferential dopamine output in limbic versus striatal projection regions: mechanism of action.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine; Dopamine Agents; Efferent Pathways; Haloperidol; Imidazoles; Indoles; Limbic System; Male; Presynaptic Terminals; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Serotonin Agents; Synaptic Transmission | 2006 |
No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Body Weight; Clozapine; Haloperidol; Humans; Olanzapine; Protein Binding; Radioligand Assay; Receptors, Cell Surface | 2007 |
Clozapine but not haloperidol treatment reverses sub-chronic phencyclidine-induced disruption of conditional discrimination performance.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Cognition Disorders; Conditioning, Operant; Discrimination Learning; Dopamine; Excitatory Amino Acid Antagonists; Goals; Haloperidol; Male; Phencyclidine; Prefrontal Cortex; Rats | 2006 |
Chronic high-dose haloperidol has qualitatively similar effects to risperidone and clozapine on immediate-early gene and tyrosine hydroxylase expression in the rat locus coeruleus but not medial prefrontal cortex.
Topics: Animals; Antipsychotic Agents; Cell Count; Clozapine; Gene Expression; Genes, Immediate-Early; Haloperidol; Immediate-Early Proteins; Immunohistochemistry; Locus Coeruleus; Male; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Risperidone; Tyrosine 3-Monooxygenase | 2007 |
Fine-tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine.
Topics: Action Potentials; Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Male; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Wakefulness | 2007 |
Differential nigral expression of Bcl-2 protein family in chronically haloperidol and clozapine-treated rats: role in neurotoxicity and stereotyped behavior.
Topics: Animals; Antipsychotic Agents; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Clozapine; Dopamine Plasma Membrane Transport Proteins; Haloperidol; Male; Neostriatum; Neurotoxicity Syndromes; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Substantia Nigra | 2007 |
Role of the simultaneous enhancement of NMDA and dopamine D1 receptor-mediated neurotransmission in the effects of clozapine on phencyclidine-induced acute increases in glutamate levels in the rat medial prefrontal cortex.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Haloperidol; Humans; Male; Microdialysis; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2006 |
Suppressive effect of clozapine but not haloperidol on the increases of neuropeptide-degrading enzymes and glial cells in MK-801-treated rat brain regions.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Glial Fibrillary Acidic Protein; Haloperidol; Metalloendopeptidases; Neuroglia; Oligonucleotides; Prolyl Oligopeptidases; Rats; Rats, Wistar; Serine Endopeptidases | 2007 |
AMPA receptor subunit and splice variant expression in the DLPFC of schizophrenic subjects and rhesus monkeys chronically administered antipsychotic drugs.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Clozapine; Female; Gene Expression; Haloperidol; Humans; Macaca mulatta; Male; Middle Aged; Prefrontal Cortex; Protein Isoforms; Receptors, AMPA; RNA, Messenger; Schizophrenia; Synaptic Transmission | 2007 |
Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studies.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Avoidance Learning; Biomarkers; Brain; Brain Chemistry; Catalepsy; Clozapine; Dopamine Agonists; Drug Evaluation, Preclinical; Haloperidol; Male; Piperazines; Prolactin; Proto-Oncogene Proteins c-fos; Psychotic Disorders; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT2; Serotonin Antagonists; Treatment Outcome | 2007 |
Chronic haloperidol treatment results in a decrease in the expression of myelin/oligodendrocyte-related genes in the mouse brain.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Brain; Clozapine; Drug Administration Schedule; Gene Expression Regulation; Haloperidol; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Myelin-Associated Glycoprotein; Nerve Tissue Proteins | 2007 |
Deficient prepulse inhibition induced by selective breeding of rats can be restored by the dopamine D2 antagonist haloperidol.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Breeding; Clozapine; Dopamine Antagonists; Female; Gait Disorders, Neurologic; Haloperidol; Inhibition, Psychological; Male; Rats; Rats, Wistar; Reflex, Startle; Serotonin Antagonists; Sex Factors | 2007 |
The atypical antipsychotic, aripiprazole, blocks phencyclidine-induced disruption of prepulse inhibition in mice.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Mice; Neural Inhibition; Olanzapine; Phencyclidine; Piperazines; Quinolones; Receptors, Dopamine D2; Reflex, Startle; Schizophrenia | 2007 |
Clozapine, SCH 23390 and alpha-flupenthixol but not haloperidol attenuate acute phencyclidine-induced disruption of conditional discrimination performance.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Clozapine; Cognition; Cognition Disorders; Conditioning, Classical; Conditioning, Operant; Discrimination Learning; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extinction, Psychological; Flupenthixol; Haloperidol; Male; Phencyclidine; Predictive Value of Tests; Rats; Reproducibility of Results; Serotonin Antagonists | 2007 |
Influence of haloperidol and clozapine on some behavioral effects in rats.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Haloperidol; Male; Maze Learning; Motor Activity; Psychomotor Performance; Rats; Rats, Wistar | 2006 |
Effects of typical and atypical antipsychotic drugs on rat brain muscarinic receptors.
Topics: Animals; Antidepressive Agents, Second-Generation; Brain; Clozapine; Female; Haloperidol; Organ Specificity; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Reference Values | 2007 |
Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cocaine; Dextroamphetamine; Dopamine Agonists; Female; Genotype; Haloperidol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Muscarinic Agonists; Receptors, Muscarinic; Reflex; Reflex, Startle; Schizophrenia; Trihexyphenidyl | 2007 |
Assessment of NMDA receptor activation in vivo by Fos induction after challenge with the direct NMDA agonist (tetrazol-5-yl)glycine: effects of clozapine and haloperidol.
Topics: Animals; Clozapine; Glycine; Haloperidol; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; N-Methylaspartate; Proto-Oncogene Proteins c-fos; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tetrazoles | 2007 |
Proteome analysis after co-administration of clozapine or haloperidol to MK-801-treated rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Drug Combinations; Excitatory Amino Acid Antagonists; Haloperidol; Male; Proteome; Rats; Rats, Sprague-Dawley; Schizophrenia; Serotonin Antagonists; Thalamus | 2007 |
Differential effects of acute and subchronic clozapine and haloperidol on phencyclidine-induced decreases in voluntary sucrose consumption in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Eating; Hallucinogens; Haloperidol; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Reward; Schizophrenia; Sucrose | 2007 |
Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Male; Microdialysis; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, AMPA; Schizophrenia; Serotonin; Synaptic Transmission | 2007 |
Clozapine-induced alteration of glucose homeostasis in the rat: the contribution of hypothalamic-pituitary-adrenal axis activation.
Topics: Animals; Antipsychotic Agents; Blood Glucose; Body Weight; Clozapine; Corticosterone; Eating; Female; Glucose; Glucose Tolerance Test; Haloperidol; Homeostasis; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
Comparative neurochemical changes associated with chronic administration of typical and atypical neuroleptics: implications in tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Body Weight; Chlorpromazine; Clozapine; Dopamine; Dyskinesia, Drug-Induced; Haloperidol; Male; Norepinephrine; Prosencephalon; Rats; Rats, Wistar; Risperidone; Serotonin | 2007 |
Effects of chronic haloperidol and/or clozapine on oxidative stress parameters in rat brain.
Topics: Animals; Antioxidants; Antipsychotic Agents; Brain; Catalase; Clozapine; Haloperidol; Humans; Male; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2007 |
Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; Imidazoles; Indoles; Male; Maze Learning; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Risperidone; Schizophrenic Psychology | 2007 |
Lack of effect of dopaminergic antagonists in a rodent model of peritoneal sepsis.
Topics: Animals; Biomarkers; Clozapine; Disease Models, Animal; Dopamine Antagonists; Haloperidol; Inflammation; Intestinal Perforation; Male; Neutrophil Infiltration; Peritoneum; Rats; Rats, Wistar; Sepsis | 2007 |
Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antimanic Agents; Antipsychotic Agents; Blotting, Western; Cell Line; Clozapine; Dishevelled Proteins; Glycogen Synthase Kinase 3; Haloperidol; Humans; Immunohistochemistry; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Lithium Chloride; Male; PC12 Cells; Phosphoproteins; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Retroviridae; Signal Transduction; Transfection; Wnt Proteins | 2007 |
Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats.
Topics: Animals; Antipsychotic Agents; Attention; Benzodiazepines; Clozapine; Cognition Disorders; Dibenzothiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Impulsive Behavior; Male; Olanzapine; Phencyclidine; Quetiapine Fumarate; Rats; Rats, Wistar; Reaction Time; Risperidone; Schizophrenia | 2007 |
Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Blotting, Western; Central Nervous System Stimulants; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Haloperidol; Hippocampus; Injections, Subcutaneous; Male; Maze Learning; Memory Disorders; Methamphetamine; Mitogen-Activated Protein Kinase 3; Phosphorylation; Rats; Rats, Wistar; Time Factors | 2007 |
The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Arginine Vasopressin; Clozapine; Deamino Arginine Vasopressin; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Habituation, Psychophysiologic; Haloperidol; Neural Inhibition; Neurotensin; Rats; Rats, Brattleboro; Rats, Long-Evans; Rats, Mutant Strains; Reflex, Startle; Risperidone; Schizophrenia; Statistics, Nonparametric | 2007 |
Dopamine and serotonin metabolism in response to chronic administration of fluvoxamine and haloperidol combined treatment.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Body Weight; Brain; Clozapine; Dopamine; Dopamine Antagonists; Drug Interactions; Fluvoxamine; Haloperidol; Immunohistochemistry; Male; Motor Activity; Neostriatum; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Tyrosine 3-Monooxygenase | 2007 |
Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine.
Topics: Animals; Antipsychotic Agents; Berberine; Calcium; Cell Line; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Protein Subunits; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 2007 |
(+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics.
Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Ketamine; Lamotrigine; Male; Pyridines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone; Schizophrenia; Sulfonamides; Thiophenes; Triazines | 2007 |
In vitro effects of antipsychotics on human platelet adhesion and aggregation and plasma coagulation.
Topics: Adult; Aged; Antipsychotic Agents; Benzodiazepines; Blood Coagulation; Blood Platelets; Clozapine; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; In Vitro Techniques; Male; Middle Aged; Olanzapine; Partial Thromboplastin Time; Platelet Adhesiveness; Platelet Aggregation; Prothrombin Time; Risperidone; Thromboembolism; Venous Thrombosis | 2007 |
Haloperidol and clozapine differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antipsychotic Agents; Clozapine; Dishevelled Proteins; Dopamine Antagonists; Frontal Lobe; Glycogen Synthase Kinase 3; Haloperidol; Male; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Signal Transduction | 2007 |
Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice.
Topics: Animals; Antipsychotic Agents; Autoradiography; Baclofen; Brain; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agonists; Haloperidol; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neural Inhibition; Receptors, GABA-B; Reflex, Startle; Schizophrenia | 2007 |
Antipsychotic medication for childhood-onset schizophrenia.
Topics: Age Factors; Antipsychotic Agents; Child; Clozapine; Haloperidol; Humans; Neutropenia; Randomized Controlled Trials as Topic; Schizophrenia; Sleep Stages; Treatment Outcome | 2007 |
Effect of antipsychotics on succinate dehydrogenase and cytochrome oxidase activities in rat brain.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brain; Clozapine; Electron Transport Complex IV; Energy Metabolism; Haloperidol; Male; Olanzapine; Piperazines; Quinolones; Rats; Rats, Wistar; Succinate Dehydrogenase | 2007 |
Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole), a dopamine D4 receptor antagonist and serotonin reuptake inhibitor: characterisation of its in vitro profile and pre-clinical antipsych
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Animals, Outbred Strains; Benzodiazepines; Cebus; Citalopram; Clozapine; Cognition; Dihydropyridines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Haloperidol; Haplorhini; Humans; Indoles; Male; Mice; Molecular Structure; Motor Activity; Olanzapine; Piperazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine D4; Risperidone; Selective Serotonin Reuptake Inhibitors; Sulfonamides | 2007 |
Functional consequences of iron overload in catecholaminergic interactions: the Youdim factor.
Topics: Animals; Animals, Newborn; Antipsychotic Agents; Brain Chemistry; Catecholamines; Clozapine; Denervation; Dopamine; Dopamine Agents; Female; Haloperidol; Iron; Iron Overload; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Movement Disorders; MPTP Poisoning; Norepinephrine; Pregnancy; Psychotic Disorders; Signal Transduction; Weight Gain | 2007 |
Recurrent priapism during treatment with clozapine, quetiapine and haloperidol.
Topics: Adult; Antipsychotic Agents; Clozapine; Dibenzothiazepines; Haloperidol; Humans; Male; Priapism; Quetiapine Fumarate; Recurrence | 2007 |
Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Brain; Chromatography, Liquid; Clozapine; Haloperidol; Isoxazoles; Male; Olanzapine; Paliperidone Palmitate; Piperazines; Pyrimidines; Rats; Reproducibility of Results; Risperidone; Tandem Mass Spectrometry; Thiazoles | 2007 |
Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine.
Topics: Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Antagonists; Haloperidol; Histocytochemistry; In Situ Hybridization; Male; Patch-Clamp Techniques; Phencyclidine; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2007 |
D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Cognition; Cognition Disorders; Dizocilpine Maleate; Exploratory Behavior; Glycine Plasma Membrane Transport Proteins; Haloperidol; Male; Nootropic Agents; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology; Sarcosine; Serine; Statistics, Nonparametric | 2008 |
Effect of chronic treatment with clozapine and haloperidol on 5-HT(2A and 2C) receptor mRNA expression in the rat brain.
Topics: Animals; Brain; Brain Chemistry; Clozapine; Dopamine Antagonists; Drug Administration Schedule; Female; Haloperidol; Neural Pathways; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; RNA, Messenger; Serotonin; Serotonin Antagonists; Synaptic Transmission | 2007 |
Long-term effects of JL 13, a potential atypical antipsychotic, on ionotropic glutamate receptors.
Topics: Animals; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Autoradiography; Benzodiazepines; Brain; Caudate Nucleus; Cerebral Cortex; Clozapine; Haloperidol; Hippocampus; Male; Olanzapine; Oxazepines; Piperazines; Putamen; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Risperidone; Tritium | 2007 |
Effects of haloperidol, clozapine and olanzapine on the survival of human neuronal and immune cells in vitro.
Topics: Adenosine Triphosphate; Antipsychotic Agents; Benzodiazepines; Cell Line, Tumor; Cell Survival; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; Monocytes; Neurons; Olanzapine; U937 Cells | 2007 |
Rehospitalization rates of patients with schizophrenia discharged on haloperidol, risperidone or clozapine.
Topics: Adult; Age of Onset; Antipsychotic Agents; Brazil; Clozapine; Epidemiologic Methods; Female; Haloperidol; Hospitals, Psychiatric; Humans; Length of Stay; Male; Patient Discharge; Patient Readmission; Risperidone; Schizophrenia; Time Factors | 2007 |
Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice.
Topics: Animals; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Exploratory Behavior; Haloperidol; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Memory Disorders; Methamphetamine; Mice; Mice, Inbred ICR; Minocycline; Mitogen-Activated Protein Kinase 3; Motor Activity; Neuroprotective Agents; Phosphorylation; Time Factors | 2008 |
Treatment of clozapine-associated tardive dyskinesia.
Topics: Adult; Anti-Dyskinesia Agents; Antipsychotic Agents; Clozapine; Cross-Over Studies; Dibenzothiepins; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Substance Withdrawal Syndrome; Treatment Outcome | 2008 |
Antipsychotic-induced suppression of locomotion in juvenile, adolescent and adult rats.
Topics: Age Factors; Aging; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Drug Tolerance; Female; Haloperidol; Male; Motor Activity; Rats; Rats, Long-Evans; Time Factors | 2008 |
Haloperidol and clozapine have dissociable effects in a model of attentional performance deficits induced by blockade of NMDA receptors in the mPFC.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Injections, Intraperitoneal; Male; Microinjections; Piperazines; Prefrontal Cortex; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serial Learning; Serotonin Antagonists | 2008 |
Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Haloperidol; Matched-Pair Analysis; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Schizophrenia; Schizophrenic Psychology; Social Behavior; Social Behavior Disorders; Thiazoles | 2008 |
Detection of the moderately beneficial cognitive effects of low-dose treatment with haloperidol or clozapine in an animal model of the attentional impairments of schizophrenia.
Topics: Animals; Attention; Clozapine; Cognition; Cognition Disorders; Disease Models, Animal; Haloperidol; Male; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Schizophrenia; Treatment Outcome | 2008 |
Dopamine binds to alpha(2)-adrenergic receptors in the song control system of zebra finches (Taeniopygia guttata).
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clozapine; Dopamine; Finches; Haloperidol; Homeostasis; Idazoxan; Male; Raclopride; Receptors, Adrenergic, alpha-2; Vocalization, Animal | 2008 |
The chakragati mouse shows deficits in prepulse inhibition of acoustic startle and latent inhibition.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Conditioning, Psychological; Disease Models, Animal; Electroshock; Female; Haloperidol; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Reflex, Startle; Risperidone; Schizophrenia | 2008 |
Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confounds.
Topics: Animals; Antipsychotic Agents; Artifacts; Brain; Brain Chemistry; Brain Diseases, Metabolic; Cerebellum; Clozapine; Confounding Factors, Epidemiologic; Energy Metabolism; Haloperidol; Humans; Hydrogen-Ion Concentration; Lactic Acid; Male; Postmortem Changes; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Up-Regulation | 2008 |
Haloperidol and clozapine differentially affect the expression of arrestins, receptor kinases, and extracellular signal-regulated kinase activation.
Topics: Animals; Arrestins; Brain; Brain Chemistry; Clozapine; Cryoultramicrotomy; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; G-Protein-Coupled Receptor Kinase 5; G-Protein-Coupled Receptor Kinases; Gene Expression; Haloperidol; Male; Rats; Rats, Sprague-Dawley | 2008 |
Chronic antipsychotic drug administration alters the expression of neuregulin 1beta, ErbB2, ErbB3, and ErbB4 in the rat prefrontal cortex and hippocampus.
Topics: Animals; Antibody Specificity; Antipsychotic Agents; Blotting, Western; Clozapine; ErbB Receptors; Glycoproteins; Haloperidol; Hippocampus; Immunohistochemistry; Male; Nerve Tissue Proteins; Neuregulin-1; Prefrontal Cortex; Rats; Rats, Wistar; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Risperidone | 2008 |
Neuroleptics and animal models: feasibility of oral treatment monitored by plasma levels and receptor occupancy assays.
Topics: Administration, Oral; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Catalepsy; Clozapine; Dose-Response Relationship, Drug; Drinking; Haloperidol; Male; Models, Animal; Olanzapine; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Time Factors | 2008 |
Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats.
Topics: Anesthetics, Intravenous; Animals; Antipsychotic Agents; Awareness; Clozapine; Dopamine; Haloperidol; Hippocampus; Long-Term Potentiation; Male; Neural Pathways; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Dopamine D1; Synapses; Urethane | 2008 |
Differential expression of IEG mRNA in rat brain following acute treatment with clozapine or haloperidol: a semi-quantitative RT-PCR study.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Gene Expression Regulation; Genes, Immediate-Early; Haloperidol; Injections, Intraperitoneal; Male; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2008 |
Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B, -4B, and -10A expression in rat striatum.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Gene Expression Regulation, Enzymologic; Haloperidol; Male; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley | 2008 |
Repeated low dose of phencyclidine administration impairs spatial learning in mice: blockade by clozapine but not by haloperidol.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Haloperidol; Learning Disabilities; Male; Maze Learning; Mice; Mice, Inbred C57BL; Motor Activity; Phencyclidine; Retention, Psychology; Rotarod Performance Test; Spatial Behavior; Time Factors | 2008 |
Clozapine may partially compensate for task-related brain perfusion abnormalities in risperidone-resistant schizophrenia patients.
Topics: Adult; Antipsychotic Agents; Brain; Cerebrovascular Disorders; Clozapine; Cognition; Drug Resistance; Female; Haloperidol; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Psychiatric Status Rating Scales; Retrospective Studies; Risperidone; Schizophrenia; Tomography, Emission-Computed, Single-Photon; Treatment Failure | 2008 |
A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats.
Topics: Animals; Antipsychotic Agents; Attention; Clozapine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Habituation, Psychophysiologic; Haloperidol; Phencyclidine; Pilot Projects; Rats; Rats, Inbred Strains; Risperidone; Set, Psychology; Sex Factors; Statistics, Nonparametric | 2008 |
Using pharmacokinetic-pharmacodynamic modelling as a tool for prediction of therapeutic effective plasma levels of antipsychotics.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Basal Ganglia; Behavior, Animal; Benzodiazepines; Binding, Competitive; Clozapine; Conditioning, Psychological; Dopamine Antagonists; Haloperidol; Imidazoles; Indoles; Injections, Subcutaneous; Male; Models, Biological; Olanzapine; Protein Binding; Raclopride; Rats; Rats, Wistar; Receptors, Dopamine D2; Reproducibility of Results; Risperidone | 2008 |
Effects of tryptophan deficiency on prepulse inhibition of the acoustic startle in rats.
Topics: Acoustic Stimulation; Amino Acids; Amphetamine; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Data Interpretation, Statistical; Diet; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Eating; Flour; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Reflex, Startle; Tryptophan; Zea mays | 2008 |
Antipsychotic-induced oxidative stress in rat brain.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brain; Clozapine; Corpus Striatum; Haloperidol; Hippocampus; Male; Olanzapine; Oxidative Stress; Piperazines; Prefrontal Cortex; Quinolones; Rats; Rats, Wistar; Superoxides; Thiobarbituric Acid Reactive Substances | 2008 |
Treatment compliance of outpatients with schizophrenia: patient's attitudes, demographic, clinical and therapeutic variables.
Topics: Administration, Oral; Adult; Age Factors; Ambulatory Care; Antipsychotic Agents; Clozapine; Cross-Sectional Studies; Delayed-Action Preparations; Female; Fluphenazine; Haloperidol; Health Knowledge, Attitudes, Practice; Humans; Long-Term Care; Male; Middle Aged; Patient Compliance; Psychiatric Status Rating Scales; Risperidone; Schizophrenia; Schizophrenic Psychology; Yugoslavia | 2008 |
[The effect of treatment on interleukin-1beta production in patients with first episode of juvenile psychosis].
Topics: Adolescent; Adult; Antipsychotic Agents; Biomarkers; Clozapine; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Haloperidol; Humans; Interleukin-1beta; Male; Psychotic Disorders; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2007 |
[Prescription of traditional neuroleptics in the remission period for schizophrenic patients with excess of body mass caused by atypical antipsychotics].
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Body Mass Index; Clozapine; Drug Prescriptions; Female; Follow-Up Studies; Haloperidol; Humans; Male; Mental Status Schedule; Olanzapine; Overweight; Risperidone; Schizophrenia; Treatment Outcome; Trifluoperazine | 2007 |
[A naturalistic, observational study of outpatients with schizophrenia: efficacy and safety results after 6 months. The International Schizophrenia Outpatient Health Outcomes study, IC-SOHO].
Topics: Adult; Aggression; Antipsychotic Agents; Basal Ganglia Diseases; Benzodiazepines; Clozapine; Dibenzothiazepines; Erectile Dysfunction; Female; Galactorrhea; Gynecomastia; Haloperidol; Humans; Hungary; International Cooperation; Libido; Male; Menstruation Disturbances; Middle Aged; Olanzapine; Outpatients; Patient Admission; Patient Compliance; Prospective Studies; Quetiapine Fumarate; Risperidone; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index | 2007 |
Did CATIE influence antipsychotic use?
Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Drug Therapy; Haloperidol; Humans; Olanzapine; Perphenazine; Piperazines; Psychotic Disorders; Quetiapine Fumarate; Risperidone; Schizophrenia; Thiazoles | 2008 |
What CATIE did: some thoughts on implications deep and wide.
Topics: Antipsychotic Agents; Basal Ganglia Diseases; Clinical Trials as Topic; Clozapine; Drug Administration Schedule; Drug Prescriptions; Haloperidol; Health Planning Guidelines; Humans; Schizophrenia | 2008 |
Lack of effect of antipsychotics on BNDF and NGF levels in hippocampus of Wistar rats.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brain-Derived Neurotrophic Factor; Clozapine; Drug Administration Schedule; Haloperidol; Hippocampus; Male; Nerve Growth Factor; Olanzapine; Piperazines; Quinolones; Rats; Rats, Wistar; Time; Up-Regulation | 2008 |
Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane?
Topics: Antipsychotic Agents; Blood Platelets; Cell Membrane; Chlorpromazine; Clozapine; Dibenzothiazepines; Haloperidol; Humans; Molecular Structure; Phosphatidylinositol Phosphates; Pimozide; Prochlorperazine; Psychotropic Drugs; Quetiapine Fumarate; Signal Transduction; Thrombin; Trifluoperazine | 2008 |
Excess of transmission of the G allele of the -1438A/G polymorphism of the 5-HT2A receptor gene in patients with schizophrenia responsive to antipsychotics.
Topics: Adenine; Adult; Algeria; Antipsychotic Agents; Clozapine; Diagnostic and Statistical Manual of Mental Disorders; Family; Female; Gene Frequency; Guanine; Haloperidol; Humans; Lithium Carbonate; Male; Patient Selection; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Receptor, Serotonin, 5-HT2A; Risperidone; Schizophrenia; Treatment Outcome | 2008 |
The putative antipsychotic alstonine reverses social interaction withdrawal in mice.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Haloperidol; Interpersonal Relations; Male; Mice; Motor Activity; Secologanin Tryptamine Alkaloids; Social Behavior Disorders; Sulpiride | 2008 |
Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: contrast with haloperidol and chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Chlordiazepoxide; Clozapine; Conditioning, Psychological; Dose-Response Relationship, Drug; Fear; Haloperidol; Hypnotics and Sedatives; Male; Motor Activity; Olanzapine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Vocalization, Animal | 2008 |
Attitudes of patients and family members towards implantable psychiatric medication.
Topics: Adult; Attitude to Health; Clozapine; Cross-Cultural Comparison; Data Collection; Drug Implants; Family; Female; Haloperidol; Humans; Male; Mental Disorders; Middle Aged; Mood Disorders; Patient Compliance; Psychotic Disorders; Psychotropic Drugs; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; United States | 2008 |
Haloperidol both prevents and reverses quinpirole-induced nonregulatory water intake, a putative animal model of psychogenic polydipsia.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Benzodiazepines; Clomipramine; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Haloperidol; Male; Olanzapine; Piperazines; Pyrroles; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Thiazepines | 2008 |
Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Caffeine; Central Nervous System Stimulants; Chromosomes, Artificial, Bacterial; Clozapine; Cocaine; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Globus Pallidus; Haloperidol; Mice; Mice, Transgenic; Neurons; Organ Culture Techniques; Phosphorylation; Substantia Nigra | 2008 |
Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells.
Topics: Antipsychotic Agents; Aspartic Acid; Cell Line, Tumor; Clozapine; Dipeptides; Dose-Response Relationship, Drug; Haloperidol; Humans; Neuroblastoma; Neurons | 2008 |
The antipsychotics clozapine and olanzapine increase plasma glucose and corticosterone levels in rats: comparison with aripiprazole, ziprasidone, bifeprunox and F15063.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Benzofurans; Benzoxazoles; Benzylamines; Blood Glucose; Clozapine; Corticosterone; Cyclopentanes; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Olanzapine; Piperazines; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Thiazoles | 2008 |
Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia.
Topics: Animals; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Hyperkinesis; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Oxotremorine; Rats; Rats, Sprague-Dawley; Reflex, Startle; Schizophrenic Psychology | 2008 |
Clozapine or Haloperidol in rats prenatally exposed to methylazoxymethanol, a compound inducing entorhinal-hippocampal deficits, alter brain and blood neurotrophins' concentrations.
Topics: Alkylating Agents; Animals; Antipsychotic Agents; Body Weight; Brain Chemistry; Clozapine; Entorhinal Cortex; Female; Granulocytes; Haloperidol; Hippocampus; Methylazoxymethanol Acetate; Nerve Growth Factors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2008 |
Towards an animal model of an antipsychotic drug-resistant cognitive impairment in schizophrenia: scopolamine induces abnormally persistent latent inhibition, which can be reversed by cognitive enhancers but not by antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Attention; Cholinergic Antagonists; Clozapine; Cognition Disorders; Conditioning, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking Behavior; Glycine; Haloperidol; Inhibition, Psychological; Male; Physostigmine; Rats; Rats, Wistar; Schizophrenia; Scopolamine | 2009 |
A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA/2 and C57BL/6 inbred mice.
Topics: Amphetamine; Animals; Antipsychotic Agents; Benzodiazepines; Brain; Clozapine; Discrimination Learning; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Olanzapine; Risperidone | 2008 |
Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Haloperidol; Inhibition, Psychological; Male; Mice; Mice, Inbred Strains; Olanzapine; Piperazines; Quinolones; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Reflex, Startle; Risperidone; Serotonin Receptor Agonists; Species Specificity | 2008 |
Antipsychotic-induced alterations in CB1 receptor-mediated G-protein signaling and in vivo pharmacology in rats.
Topics: Aging; Animals; Antipsychotic Agents; Cells, Cultured; CHO Cells; Clozapine; Cricetinae; Cricetulus; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Dronabinol; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Rimonabant; Sex Characteristics; Signal Transduction | 2008 |
Amisulpride the 'atypical' atypical antipsychotic--comparison to haloperidol, risperidone and clozapine.
Topics: Amisulpride; Amphetamine; Animals; Antipsychotic Agents; Basal Ganglia; Behavior, Animal; Blood-Brain Barrier; Brain; Clozapine; Conditioning, Psychological; Haloperidol; Male; Models, Animal; Motor Activity; Phencyclidine; Prefrontal Cortex; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Risperidone; Sulpiride | 2008 |
Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation.
Topics: Acetylation; Animals; Benzodiazepines; Brain; Cell Adhesion Molecules, Neuronal; Clozapine; DNA Methylation; Extracellular Matrix Proteins; Glutamate Decarboxylase; Haloperidol; Histones; Lysine; Male; Mice; Nerve Tissue Proteins; Olanzapine; Promoter Regions, Genetic; Reelin Protein; Serine Endopeptidases; Sulpiride; Valproic Acid | 2008 |
Antipsychotics possessing antidepressive efficacy increase Golf protein in rat striatum.
Topics: Amisulpride; Animals; Antipsychotic Agents; Benzodiazepines; Blotting, Western; Clozapine; Corpus Striatum; Depressive Disorder; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits; Haloperidol; Injections, Intraperitoneal; Male; Olanzapine; Rats; Rats, Wistar; Risperidone; Sulpiride; Time Factors | 2008 |
Delta-9-tetrahydrocannabinol differently affects striatal c-Fos expression following haloperidol or clozapine administration.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Clozapine; Dronabinol; Gene Expression; Genes, fos; Haloperidol; Immunohistochemistry; Male; Neostriatum; Neurons; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Coregulation of genes in the mouse brain following treatment with clozapine, haloperidol, or olanzapine implicates altered potassium channel subunit expression in the mechanism of antipsychotic drug action.
Topics: Animals; Antipsychotic Agents; Base Sequence; Benzodiazepines; Blotting, Western; Brain; Clozapine; DNA Primers; Gene Expression Profiling; Gene Expression Regulation; Haloperidol; Male; Mice; Mice, Inbred C57BL; Models, Animal; Olanzapine; Oligonucleotide Array Sequence Analysis; Potassium Channels; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Decreased M1 muscarinic receptor density in rat amphetamine model of schizophrenia is normalized by clozapine, but not haloperidol.
Topics: Amphetamine; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; DNA Primers; Haloperidol; Male; Muscarinic Antagonists; Pirenzepine; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Schizophrenia; Schizophrenic Psychology | 2008 |
Fluctuation of latent inhibition along the estrous cycle in the rat: modeling the cyclicity of symptoms in schizophrenic women?
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Conditioning, Psychological; Data Interpretation, Statistical; Emotions; Estrous Cycle; Female; Haloperidol; Rats; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Vagina | 2008 |
Evaluating early preventive antipsychotic and antidepressant drug treatment in an infection-based neurodevelopmental mouse model of schizophrenia.
Topics: Age Factors; Amphetamine; Animals; Animals, Newborn; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Brain; Central Nervous System Stimulants; Clozapine; Disease Models, Animal; Female; Haloperidol; Male; Mice; Mice, Inbred C57BL; Motor Activity; Neural Inhibition; Polynucleotides; Pregnancy; Prenatal Exposure Delayed Effects; Schizophrenia; Schizophrenic Psychology; Sensory Gating | 2010 |
Exacerbation of tics secondary to clozapine therapy.
Topics: Agranulocytosis; Antipsychotic Agents; Clozapine; Disease Progression; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Schizophrenia; Tourette Syndrome; Young Adult | 2008 |
Sedation and disruption of maternal motivation underlie the disruptive effects of antipsychotic treatment on rat maternal behavior.
Topics: Animals; Antipsychotic Agents; Anxiety, Separation; Chlordiazepoxide; Clozapine; Data Interpretation, Statistical; Dopamine Antagonists; Female; Haloperidol; Hypnotics and Sedatives; Maternal Behavior; Motivation; Nesting Behavior; Rats; Rats, Sprague-Dawley | 2009 |
To breed or not to breed? Empirical evaluation of drug effects in adolescent rats.
Topics: Aging; Animals; Antipsychotic Agents; Breeding; Catalepsy; Clozapine; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Environment; Female; Haloperidol; Male; Motor Activity; Neuropharmacology; Pain Threshold; Psychotropic Drugs; Rats; Rats, Long-Evans; Sex Characteristics; Stress, Psychological | 2009 |
Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibition on amphetamine-induced hyperlocomotion: relevance to animal models of antipsychotic drugs.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Clozapine; Disease Models, Animal; Haloperidol; Hyperkinesis; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
NMDA antagonist and antipsychotic actions in cortico-subcortical circuits.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Clozapine; Haloperidol; Male; Neural Pathways; Phencyclidine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Pyramidal Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Thalamic Nuclei | 2008 |
WAY-163909, a 5-HT2C agonist, enhances the preclinical potency of current antipsychotics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Azepines; Catalepsy; Clozapine; Dizocilpine Maleate; Drug Synergism; Drug Therapy, Combination; Haloperidol; Indoles; Male; Mice; Rats; Rats, Sprague-Dawley; Reflex, Startle; Serotonin 5-HT2 Receptor Agonists; Stereotyped Behavior | 2009 |
Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Cytokines; Haloperidol; Interleukin-10; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Olanzapine; Poly I-C; Risperidone; Serotonin Antagonists; Tumor Necrosis Factor-alpha | 2009 |
Disruption of latent inhibition induced by ovariectomy can be reversed by estradiol and clozapine as well as by co-administration of haloperidol with estradiol but not by haloperidol alone.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Estradiol; Estrogens; Female; Haloperidol; Humans; Ovariectomy; Rats; Rats, Wistar; Schizophrenia | 2009 |
Clozapine-induced ERK1 and ERK2 signaling in prefrontal cortex is mediated by the EGF receptor.
Topics: Animals; Antipsychotic Agents; Cells, Cultured; Cholinergic Agents; Clozapine; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gi-Go; Haloperidol; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Prefrontal Cortex; Raclopride; Serotonin Agents; Signal Transduction; Type C Phospholipases | 2009 |
Effects of antipsychotics and vitamin C on the formation of reactive oxygen species.
Topics: Animals; Antioxidants; Antipsychotic Agents; Ascorbic Acid; Benzodiazepines; Blood; Clozapine; Electron Spin Resonance Spectroscopy; Haloperidol; Olanzapine; Osmolar Concentration; Oxidative Stress; Rats; Reactive Oxygen Species | 2010 |
Agmatine disrupts prepulse inhibition of acoustic startle reflex in rats.
Topics: Acoustic Stimulation; Agmatine; Analysis of Variance; Animals; Antipsychotic Agents; Apomorphine; Clozapine; Dibenzothiazepines; Dopamine Agonists; Haloperidol; Male; Quetiapine Fumarate; Rats; Rats, Wistar; Reflex, Startle; Sensory Gating | 2010 |
Antipsychotics affect multiple calcium calmodulin dependent proteins.
Topics: Animals; Antipsychotic Agents; Calcineurin; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinase Type 4; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Clozapine; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Psychotropic Drugs; Raclopride; Rats; Rats, Sprague-Dawley; Risperidone; RNA, Messenger | 2009 |
Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells.
Topics: Alternative Splicing; Antipsychotic Agents; Aripiprazole; Astrocytoma; Benzodiazepines; Cell Line, Tumor; Clozapine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Haloperidol; Humans; Olanzapine; Piperazines; Quinolones; Receptors, Dopamine D2; Reverse Transcriptase Polymerase Chain Reaction; Risperidone; RNA-Binding Proteins; RNA, Messenger; Time Factors | 2009 |
[Peculiarities of neuroleptic syndrome in women treated with typical and atypical neuroleptics].
Topics: Adult; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Haloperidol; Humans; Neuroleptic Malignant Syndrome; Risperidone; Sexuality; Treatment Outcome | 2009 |
A role for dopamine D2 receptors in reversal learning.
Topics: Animals; Clozapine; Cognition; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Early Growth Response Protein 2; Frontal Lobe; Gene Expression; Haloperidol; Learning Disabilities; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropsychological Tests; Neurotransmitter Agents; Prefrontal Cortex; Receptors, Dopamine D2; Reversal Learning; RNA, Messenger | 2009 |
Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzamides; Benzodiazepines; Benzoxazoles; Catalepsy; Clozapine; Dibenzothiazepines; Dioxanes; Dopamine Antagonists; Female; Haloperidol; Macaca fascicularis; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Remoxipride; Risperidone; Serotonin Receptor Agonists; Thiazoles; Tropanes; Video Recording | 2009 |
Dopamine D2/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine.
Topics: Adult; Antipsychotic Agents; Benzamides; Benzodiazepines; Clozapine; Female; Haloperidol; Humans; Iodine Radioisotopes; Male; Mesencephalon; Middle Aged; Olanzapine; Pyrrolidines; Receptors, Dopamine D2; Receptors, Dopamine D3; Schizophrenia; Temporal Lobe; Tomography, Emission-Computed, Single-Photon | 2009 |
Upregulation of NRG-1 and VAMP-1 in human brain aggregates exposed to clozapine.
Topics: Antipsychotic Agents; Brain; Clozapine; Fetus; Haloperidol; Humans; Neuregulin-1; Up-Regulation; Vesicle-Associated Membrane Protein 1 | 2009 |
Prefrontal cortex and reversion of atropine-induced disruption of the degraded contingency effect by antipsychotic agents and N-desmethylclozapine in rats.
Topics: Animals; Antipsychotic Agents; Atropine; Benzodiazepines; Clozapine; Conditioning, Classical; Drug Interactions; Haloperidol; Male; Muscarinic Antagonists; Olanzapine; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2010 |
The receptor mechanisms underlying the disruptive effects of haloperidol and clozapine on rat maternal behavior: a double dissociation between dopamine D(2) and 5-HT(2A/2C) receptors.
Topics: Amphetamines; Animals; Antipsychotic Agents; Clozapine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Haloperidol; Maternal Behavior; Nesting Behavior; Postpartum Period; Pregnancy; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Dopamine D2; Serotonin Receptor Agonists | 2009 |
Nitric oxide modulation of methylphenidate-induced disruption of prepulse inhibition in Swiss mice.
Topics: Animals; Auditory Perception; Clozapine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Antagonists; Haloperidol; Indazoles; Male; Methylphenidate; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Reflex, Startle | 2009 |
The effects of the second generation antipsychotics and a typical neuroleptic on collagen-induced platelet aggregation in vitro.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Collagen; Female; Haloperidol; Humans; In Vitro Techniques; Male; Olanzapine; Platelet Activation; Platelet Aggregation; Risperidone | 2010 |
F15063, a potential antipsychotic with dopamine D(2)/D(3) receptor antagonist and 5-HT(1A) receptor agonist properties: influence on immediate-early gene expression in rat prefrontal cortex and striatum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Benzofurans; Benzylamines; Clozapine; Cyclopentanes; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Genes, Immediate-Early; Haloperidol; Male; Mitogen-Activated Protein Kinase 3; Neostriatum; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine; Receptors, Dopamine D3; RNA, Messenger; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Time Factors | 2009 |
Effects of antipsychotic drugs on MK-801-induced attentional and motivational deficits in rats.
Topics: Animals; Antipsychotic Agents; Attention; Clozapine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Male; Motivation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time; Reward | 2009 |
[Complex therapy of schizophrenia].
Topics: Adolescent; Adult; Antipsychotic Agents; Art Therapy; Benzodiazepines; Clinical Trials as Topic; Clozapine; Cognitive Behavioral Therapy; Combined Modality Therapy; Dance Therapy; Dibenzothiazepines; Female; Haloperidol; Humans; Male; Middle Aged; Music Therapy; Occupational Therapy; Olanzapine; Psychotherapy; Quetiapine Fumarate; Retrospective Studies; Risperidone; Schizophrenia; Schizophrenic Psychology; Single-Blind Method; Suicide; Treatment Outcome; Young Adult | 2009 |
Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Haloperidol; Hypothalamus; Immunohistochemistry; Male; Neurons; Olanzapine; Oxytocin; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Risperidone; Supraoptic Nucleus; Vasopressins | 2010 |
Chronic NT69L potently prevents drug-induced disruption of prepulse inhibition without causing tolerance.
Topics: Acoustic Stimulation; Amphetamine; Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Dopamine Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Haloperidol; Neurotensin; Peptide Fragments; Rats; Sensory Gating | 2010 |
Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia.
Topics: Adult; Aged; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bipolar Disorder; Clozapine; Depressive Disorder, Major; Female; Gene Expression Regulation; Haloperidol; Hippocampus; Humans; Imipramine; Male; Mesothelin; Middle Aged; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schizophrenia; Statistics as Topic; Temporal Lobe; Vesicular Glutamate Transport Proteins | 2009 |
The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-D-aspartate and D1 receptor binding in rats.
Topics: Aging; Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dopamine Antagonists; Frontal Lobe; Haloperidol; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Isolation | 2010 |
A new model of the disrupted latent inhibition in C57BL/6J mice after bupropion treatment.
Topics: Amphetamine; Animals; Bupropion; Clozapine; Conditioning, Psychological; Disease Models, Animal; Dopamine Agonists; Dopamine Uptake Inhibitors; Drug Interactions; Haloperidol; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Phosphodiesterase 4 Inhibitors; Piperazines; Rolipram; Schizophrenic Psychology | 2010 |
Modulation of prepulse inhibition through both M(1) and M (4) muscarinic receptors in mice.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Female; Haloperidol; Male; Mice; Mice, Knockout; Muscarinic Agonists; Muscarinic Antagonists; Oxotremorine; Pyridines; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Reflex, Startle; Scopolamine; Thiadiazoles | 2010 |
Antipsychotic-like effects of the N-methyl-D-aspartate receptor modulator neboglamine: an immunohistochemical and behavioural study in the rat.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Hallucinogens; Haloperidol; Immunohistochemistry; Male; Motor Activity; Pentanoic Acids; Phencyclidine; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Serine | 2010 |
Do antipsychotic medications reduce or increase mortality in schizophrenia? A critical appraisal of the FIN-11 study.
Topics: Adult; Antipsychotic Agents; Clozapine; Dibenzothiazepines; Female; Finland; Haloperidol; Humans; Male; Perphenazine; Quetiapine Fumarate; Risperidone; Schizophrenia; Suicide; Survival Rate | 2010 |
A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Female; Haloperidol; Humans; Male; Middle Aged; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Schizophrenia; SNARE Proteins | 2010 |
c-Fos identification of neuroanatomical sites associated with haloperidol and clozapine disruption of maternal behavior in the rat.
Topics: Amphetamines; Animals; Animals, Newborn; Antipsychotic Agents; Biomarkers; Brain; Clozapine; Dopamine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Immunohistochemistry; Male; Maternal Behavior; Neostriatum; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Septum of Brain; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists | 2010 |
The involvement of GABA(A) receptor in the molecular mechanisms of combined selective serotonin reuptake inhibitor-antipsychotic treatment.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cells, Cultured; Clozapine; Dopamine; Drug Therapy, Combination; Fluvoxamine; Haloperidol; Male; Mitogen-Activated Protein Kinase 1; Mood Disorders; Obsessive-Compulsive Disorder; Phosphorylation; Prefrontal Cortex; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Schizophrenia; Selective Serotonin Reuptake Inhibitors | 2011 |
D-Serine and a glycine transporter-1 inhibitor enhance social memory in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Glycine Plasma Membrane Transport Proteins; Haloperidol; Male; Memory; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Serine; Social Behavior; Time Factors | 2010 |
The first- and second-generation antipsychotic drugs affect ADP-induced platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Female; Haloperidol; Humans; Male; Olanzapine; Platelet Activation; Platelet Aggregation; Risperidone | 2010 |
Haloperidol and clozapine decrease S100B release from glial cells.
Topics: Animals; Antipsychotic Agents; Cell Line, Tumor; Clozapine; Culture Media; Culture Media, Serum-Free; Glucose; Haloperidol; Immunohistochemistry; Nerve Growth Factors; Neuroglia; Rats; Receptors, Neurotransmitter; S100 Calcium Binding Protein beta Subunit; S100 Proteins | 2010 |
Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Body Weight; Brain Chemistry; Cholesterol; Clozapine; Haloperidol; Male; Phospholipids; Rats; Rats, Sprague-Dawley | 2010 |
Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis?
Topics: Amphetamine; Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Estrogens; Female; Haloperidol; Inhibition, Psychological; Ovariectomy; Psychotic Disorders; Rats; Rats, Wistar; Statistics, Nonparametric; Water Deprivation | 2010 |
The role of CYP2D6 and TaqI A polymorphisms in malignant neuroleptic syndrome: two case reports with three episodes.
Topics: Adult; Alleles; Antipsychotic Agents; Bipolar Disorder; Clozapine; Cytochrome P-450 CYP2D6; Dibenzothiazepines; Drug Therapy, Combination; Fluphenazine; Genetic Carrier Screening; Genotype; Haloperidol; Humans; Lithium Carbonate; Male; Neuroleptic Malignant Syndrome; Perazine; Polymorphism, Genetic; Psychotic Disorders; Quetiapine Fumarate; Receptors, Dopamine D2; Recurrence; Risperidone | 2010 |
Treatment of a tardive dyskinesia patient with temporomandibular disorder: a case report.
Topics: Aged; Antipsychotic Agents; Botulinum Toxins, Type A; Bruxism; Clozapine; Dyskinesia, Drug-Induced; Facial Pain; Follow-Up Studies; GABA Antagonists; Haloperidol; Humans; Male; Muscle Contraction; Neuromuscular Agents; Osteoarthritis; Recurrence; Schizophrenia; Temporomandibular Joint Disorders | 2010 |
The antipsychotics olanzapine, risperidone, clozapine, and haloperidol are D2-selective ex vivo but not in vitro.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Humans; In Vitro Techniques; Male; Olanzapine; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Risperidone; Tritium; Vitamin K 1 | 2010 |
A parametric study of the acute effects of antipsychotic drugs on glucose sensitivity in an animal model.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Blood Glucose; Clozapine; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Glucose Tolerance Test; Haloperidol; Insulin; Insulin Resistance; Rats; Rats, Sprague-Dawley; Risperidone | 2010 |
Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Carnitine; Clozapine; Energy Metabolism; Fatty Acids, Nonesterified; Female; Haloperidol; Insulin Resistance; Lipolysis; Male; Malonyl Coenzyme A; Mice; Olanzapine; Piperazines; Rats; Rats, Sprague-Dawley; Risperidone; Thiazoles; Vitamin B Complex | 2012 |
A prospective longitudinal study of cholesterol and aggression in patients randomized to clozapine, olanzapine, and haloperidol.
Topics: Aggression; Benzodiazepines; Cholesterol; Clozapine; Cross-Sectional Studies; Double-Blind Method; Haloperidol; Humans; Longitudinal Studies; Olanzapine; Prospective Studies; Randomized Controlled Trials as Topic | 2010 |
Prescription persistence and safety of antipsychotic medication: a national registry-based 3-year follow-up.
Topics: Adult; Aged; Antiparkinson Agents; Antipsychotic Agents; Chlorprothixene; Cholinergic Antagonists; Clopenthixol; Clozapine; Drug Prescriptions; Female; Follow-Up Studies; Haloperidol; Humans; Logistic Models; Male; Methotrimeprazine; Middle Aged; Mortality; Norway; Odds Ratio; Piperazines; Registries; Thiazoles | 2010 |
p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission.
Topics: Animals; Benzazepines; Clozapine; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Oxidopamine; p-Hydroxyamphetamine; Piperazines; Piperidines; Pyridines; Pyrroles; Reflex, Startle; Salicylamides; Sensory Gating; Sympathomimetics; Synaptic Transmission | 2010 |
The effects of clozapine on quinpirole-induced non-regulatory drinking and prepulse inhibition disruption in rats.
Topics: Animals; Antipsychotic Agents; Brain; Brain-Derived Neurotrophic Factor; Clozapine; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Drinking; Gene Expression Regulation; Haloperidol; Male; Proto-Oncogene Proteins c-fos; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Schizophrenia | 2010 |
Distinct neural mechanisms underlying acute and repeated administration of antipsychotic drugs in rat avoidance conditioning.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Administration Schedule; Haloperidol; Male; Olanzapine; Rats; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists | 2010 |
Extrapyramidal side-effects and dopamine D(2/3) receptor binding in substantia nigra.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Brain Mapping; Clozapine; Female; Haloperidol; Humans; Magnetic Resonance Imaging, Interventional; Male; Olanzapine; Receptors, Dopamine D2; Receptors, Dopamine D3; Schizophrenia; Substantia Nigra; Tomography, Emission-Computed, Single-Photon | 2010 |
Effect of 'chronic' versus 'acute' ketamine administration and its 'withdrawal' effect on behavioural alterations in mice: implications for experimental psychosis.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Clozapine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Haloperidol; Ketamine; Male; Mice; Motor Activity; Psychotic Disorders; Random Allocation; Risperidone; Schizophrenia; Substance Withdrawal Syndrome; Swimming | 2011 |
Alterations in the level of neurotransmitters associated with the chronic treatment of antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Brain; Chromatography, High Pressure Liquid; Clozapine; Dopamine; Dopamine Antagonists; Haloperidol; Neurotransmitter Agents; Rats; Serotonin; Serotonin Antagonists; Tryptophan | 2010 |
The impact of antipsychotic drugs on food intake and body weight and on leptin levels in blood and hypothalamic ob-r leptin receptor expression in wistar rats.
Topics: Animals; Antipsychotic Agents; Blotting, Western; Clozapine; Eating; Exploratory Behavior; Haloperidol; Hypothalamus; Leptin; Male; Motor Activity; Piperazines; Rats; Rats, Wistar; Receptors, Leptin; Thiazoles; Time Factors; Weight Gain | 2010 |
Data openness. Don't forget preclinical science.
Topics: Antipsychotic Agents; Clozapine; Drug Evaluation, Preclinical; Drug Industry; Haloperidol | 2010 |
Pharmacological characterizations of memantine-induced disruption of prepulse inhibition of the acoustic startle response in mice: involvement of dopamine D2 and 5-HT2A receptors.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Benzazepines; Clozapine; Dopamine Agents; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Ketanserin; Male; Memantine; Mice; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Reflex, Startle; Risperidone; Sensory Gating | 2011 |
The atypical anti-psychotic clozapine decreases bone mass in rats in vivo.
Topics: Absorptiometry, Photon; Analysis of Variance; Animals; Antipsychotic Agents; Bone and Bones; Bone Density; Bone Resorption; Cell Differentiation; Cell Proliferation; Cells, Cultured; Clozapine; Haloperidol; Male; Osteoblasts; Rats; Rats, Sprague-Dawley; Testosterone; Thymidine; Time Factors; Tritium | 2011 |
The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in rats.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Central Nervous System Stimulants; Clozapine; Conditioning, Classical; Dextroamphetamine; Drug Evaluation, Preclinical; Haloperidol; Male; Neurotensin; Rats; Rats, Sprague-Dawley; Receptors, Neurotensin | 2011 |
Protective effects of haloperidol and clozapine on energy-deprived OLN-93 oligodendrocytes.
Topics: Animals; Antigens; Antipsychotic Agents; Basic Helix-Loop-Helix Transcription Factors; Caspase 3; Cell Line, Transformed; Clozapine; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Energy Metabolism; Haloperidol; Nerve Tissue Proteins; Oligodendrocyte Transcription Factor 2; Oligodendroglia; Proteoglycans; Rats | 2011 |
Evaluation of five antischizophrenic agents against Toxoplasma gondii in human cell cultures.
Topics: Antipsychotic Agents; Cell Line; Clozapine; Fibroblasts; Fluphenazine; Haloperidol; Humans; Schizophrenia; Thioridazine; Toxoplasma; Toxoplasmosis; Trifluoperazine | 2011 |
Clozapine increases reward evaluation but not overall ingestive behaviour in rats licking for sucrose.
Topics: Anhedonia; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Data Interpretation, Statistical; Dopamine Antagonists; Feeding Behavior; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Reward; Ritanserin; Serotonin Antagonists; Sucrose | 2011 |
Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine Plasma Membrane Transport Proteins; Haloperidol; Immunohistochemistry; Mesencephalon; Neurons; Rats; Rats, Sprague-Dawley; Risperidone; Tyrosine 3-Monooxygenase | 2011 |
Time course of the attenuation effect of repeated antipsychotic treatment on prepulse inhibition disruption induced by repeated phencyclidine treatment.
Topics: Acoustic Stimulation; Animals; Antipsychotic Agents; Clozapine; Dibenzothiazepines; Drug Interactions; Hallucinogens; Haloperidol; Humans; Male; Models, Animal; Motor Activity; Phencyclidine; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone | 2011 |
Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Aspartic Acid; Choline; Clozapine; Corpus Striatum; Creatine; Dose-Response Relationship, Drug; Glutamic Acid; Haloperidol; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley | 2011 |
Folie à deux: double case-report of shared delusions with a fatal outcome.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Clozapine; Combined Modality Therapy; Epilepsy; Fatal Outcome; Female; Haloperidol; Humans; Nordazepam; Olanzapine; Patient Compliance; Psychotherapy; Psychotic Disorders; Schizophrenia, Paranoid; Shared Paranoid Disorder; Sibling Relations; Suicide; Valproic Acid | 2011 |
Administration of clozapine to a mother rat potentiates pup ultrasonic vocalization in response to separation and re-separation: contrast with haloperidol.
Topics: Animals; Animals, Newborn; Clozapine; Female; Haloperidol; Male; Maternal Behavior; Maternal Deprivation; Rats; Rats, Sprague-Dawley; Vocalization, Animal | 2011 |
[The effect of serotonin on the cytotoxic activity of natural killer lymphocytes in patients with the first episode of endogenous psychosis].
Topics: Adolescent; Adult; Antipsychotic Agents; Clozapine; Cytotoxicity, Immunologic; Haloperidol; Humans; Killer Cells, Natural; Male; Psychotic Disorders; Schizophrenia; Serotonin; Young Adult | 2011 |
Dopamine selectively modulates lipopolysaccharide-induced TNF-alpha, IFN-gamma and IL-10 within mice tissues.
Topics: Adult; Animals; Brain; Cells, Cultured; Clozapine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Interferon-gamma; Interleukin-10; Lipopolysaccharides; Liver; Lung; Male; Mice; Mice, Inbred BALB C; Models, Animal; Receptors, Dopamine; Spleen; Tumor Necrosis Factor-alpha | 2011 |
Does the association with diabetes say more about schizophrenia and its treatment?--the GLUT hypothesis.
Topics: Animals; Clozapine; Diabetes Complications; Dopamine; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 3; Haloperidol; Humans; Mice; Models, Theoretical; Schizophrenia | 2011 |
Abnormally rapid reversal learning and reduced response to antipsychotic drugs following ovariectomy in female rats.
Topics: Animals; Antipsychotic Agents; Attention; Clozapine; Discrimination Learning; Estradiol; Estrogens; Female; Haloperidol; Models, Animal; Ovariectomy; Rats; Rats, Wistar; Reversal Learning; Schizophrenia | 2012 |
Slow dissociation of partial agonists from the D₂ receptor is linked to reduced prolactin release.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Dibenzothiazepines; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Piperazines; Prolactin; Quetiapine Fumarate; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 2012 |
Acute administration of typical and atypical antipsychotics reduces EEG γ power, but only the preclinical compound LY379268 reduces the ketamine-induced rise in γ power.
Topics: Amino Acids; Animals; Antipsychotic Agents; Brain Waves; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Clozapine; Drug Administration Schedule; Electrodes, Implanted; Excitatory Amino Acid Antagonists; Haloperidol; Ketamine; Male; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2012 |
Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo.
Topics: Animals; Behavior, Animal; Benzodiazepines; Blotting, Western; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Motor Activity; Olanzapine; Phencyclidine; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Stereotyped Behavior; Up-Regulation | 2011 |
Antipsychotic drugs suppress the AKT/NF-κB pathway and regulate the differentiation of T-cell subsets.
Topics: Antipsychotic Agents; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Clozapine; GATA3 Transcription Factor; Haloperidol; Humans; NF-kappa B; Oncogene Protein v-akt; Risperidone; Schizophrenia; Signal Transduction; T-Box Domain Proteins; T-Lymphocyte Subsets; Th1-Th2 Balance | 2011 |
Association of plasma retinol-binding protein-4, adiponectin, and high molecular weight adiponectin with metabolic adversities in patients with schizophrenia.
Topics: Adiponectin; Adult; Antipsychotic Agents; Blood Pressure; Body Mass Index; Clozapine; Female; Haloperidol; Humans; Male; Metabolic Syndrome; Middle Aged; Retinol-Binding Proteins, Plasma; Schizophrenia; Waist Circumference | 2011 |
Effects of antipsychotics with different weight gain liabilities on human in vitro models of adipose tissue differentiation and metabolism.
Topics: Adipocytes; Adipogenesis; Adipose Tissue; Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Female; Haloperidol; Humans; Olanzapine; Piperazines; Thiazoles; Weight Gain | 2011 |
[Clinical characteristics of cannabis-induced schizophrenia spectrum disorder].
Topics: Adolescent; Adult; Aggression; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Dibenzothiazepines; Hallucinations; Haloperidol; Humans; Hungary; Male; Marijuana Abuse; Olanzapine; Paranoid Disorders; Piperazines; Psychomotor Performance; Quetiapine Fumarate; Quinolones; Retrospective Studies; Risperidone; Schizophrenia; Schizophrenic Psychology | 2011 |
Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes.
Topics: Animals; Antipsychotic Agents; Astrocytes; Cells, Cultured; Citrates; Clozapine; Glutamic Acid; Haloperidol; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine; Tetanus Toxin; Tetrodotoxin | 2012 |
A clozapine-like effect of cyproheptadine on progressive ratio schedule performance.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chlordiazepoxide; Clozapine; Conditioning, Operant; Cyproheptadine; Dronabinol; Eating; Female; Haloperidol; Motivation; Performance-Enhancing Substances; Psychomotor Performance; Rats; Rats, Wistar; Reinforcement Schedule; Reinforcement, Psychology | 2012 |
Effects of amisulpride and aripiprazole on progressive-ratio schedule performance: comparison with clozapine and haloperidol.
Topics: Amisulpride; Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Clozapine; Conditioning, Operant; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Kinetics; Models, Biological; Motor Activity; Motor Skills; Piperazines; Quinolones; Rats; Rats, Wistar; Reaction Time; Reinforcement Schedule; Serotonin Antagonists; Sulpiride | 2012 |
The effects of neuropsychiatric drugs on glycogen synthase kinase-3 signaling.
Topics: Animals; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; beta Catenin; Blotting, Western; Brain; Clozapine; Fluoxetine; Glycogen Synthase Kinase 3; Haloperidol; Imipramine; Immunoprecipitation; Lithium; Male; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Valproic Acid | 2011 |
Antipsychotic drugs and risk of pulmonary embolism.
Topics: Adult; Aged; Antipsychotic Agents; Clozapine; Databases, Factual; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Logistic Models; Male; Middle Aged; Pulmonary Embolism; Retrospective Studies; Risk; United States | 2012 |
Differential effect of clozapine and haloperidol on rats treated with methylphenidate in the open field test.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Haloperidol; Male; Methylphenidate; Rats; Rats, Wistar | 2009 |
Comparative gene expression study of the chronic exposure to clozapine and haloperidol in rat frontal cortex.
Topics: Animals; Antipsychotic Agents; bcl-X Protein; Catechol O-Methyltransferase; Cell Adhesion Molecules; Clozapine; Frontal Lobe; Gene Expression Profiling; Gene Expression Regulation; GPI-Linked Proteins; Haloperidol; Male; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2012 |
Onset of action of atypical and typical antipsychotics in the treatment of adolescent schizophrenic psychoses.
Topics: Adolescent; Antipsychotic Agents; Benzodiazepines; Clozapine; Dibenzothiazepines; Female; Haloperidol; Humans; Male; Medical Records; Olanzapine; Perphenazine; Piperazines; Psychotic Disorders; Quetiapine Fumarate; Risperidone; Schizophrenia; Sulpiride; Thiazoles; Time Factors; Treatment Outcome | 2011 |
An animal model to study the molecular basis of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Apoptosis; Behavior, Animal; Caspase 3; Clozapine; Disease Models, Animal; Dyskinesia, Drug-Induced; Haloperidol; Humans; Male; Movement Disorders; Pregnatrienes; Rats; Rats, Wistar | 2012 |
Clozapine inhibits Th1 cell differentiation and causes the suppression of IFN-γ production in peripheral blood mononuclear cells.
Topics: Antipsychotic Agents; CD4 Lymphocyte Count; Cell Differentiation; Clozapine; GATA3 Transcription Factor; Gene Expression Regulation; Haloperidol; Humans; Interferon-gamma; Interleukin-4; STAT6 Transcription Factor; Th1 Cells; Th2 Cells | 2012 |
[Neonatal withdrawal syndrome associated with maternal clozapine and haloperidol therapy].
Topics: Clozapine; Haloperidol; Humans; Infant, Newborn; Male; Neonatal Abstinence Syndrome | 2011 |
Haloperidol and clozapine block formation of autophagolysosomes in rat primary neurons.
Topics: Animals; Antipsychotic Agents; Autophagy; Blotting, Western; Cell Survival; Cells, Cultured; Clozapine; Fluorescent Antibody Technique; Haloperidol; Neurons; Phagosomes; Rats | 2012 |
Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment.
Topics: Aged; Alleles; Animals; Antipsychotic Agents; Cerebellum; Clozapine; Disease Models, Animal; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Excitatory Amino Acid Transporter 4; Female; Gene Expression Regulation; Haloperidol; Humans; Male; Middle Aged; Neuregulin-1; Polymorphism, Single Nucleotide; Rats; Rats, Sprague-Dawley; Risk Factors; Schizophrenia | 2013 |
Neural basis of the potentiated inhibition of repeated haloperidol and clozapine treatment on the phencyclidine-induced hyperlocomotion.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Brain; Clozapine; Haloperidol; Hyperkinesis; Male; Motor Activity; Neurons; Phencyclidine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2012 |
Discriminative stimulus properties of N-desmethylclozapine, the major active metabolite of the atypical antipsychotic clozapine, in C57BL/6 mice.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Discrimination Learning; Generalization, Psychological; Haloperidol; Male; Mice; Mice, Inbred C57BL; Piperazines; Quinolones | 2012 |
Ketamine-enhanced immobility in forced swim test: a possible animal model for the negative symptoms of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Female; Haloperidol; Immobility Response, Tonic; Ketamine; Male; Motor Activity; Rats; Rats, Wistar; Reproducibility of Results; Risperidone; Schizophrenia; Swimming | 2012 |
Differential effects of antipsychotics on hippocampal presynaptic protein expressions and recognition memory in a schizophrenia model in mice.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Frontal Lobe; Haloperidol; Hippocampus; Male; Mice; Motor Activity; Presynaptic Terminals; Recognition, Psychology; Schizophrenia; Synaptophysin; Synaptosomal-Associated Protein 25 | 2012 |
Intensive electroconvulsive therapy in drug resistant neuroleptic malignant syndrome - case report.
Topics: Adult; Antipsychotic Agents; Clozapine; Electroconvulsive Therapy; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome | 2012 |
A gene expression and systems pathway analysis of the effects of clozapine compared to haloperidol in the mouse brain implicates susceptibility genes for schizophrenia.
Topics: Animals; Antipsychotic Agents; Brain; Cell Cycle Proteins; Clozapine; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Haloperidol; Male; Mice; Mice, Inbred C57BL; Microtubule Proteins; Nerve Tissue Proteins; Neurons; Oligonucleotide Array Sequence Analysis; Organ Specificity; Pilot Projects; RNA, Messenger; Schizophrenia | 2012 |
Persistent effects of chronic clozapine on the cellular and behavioral responses to LSD in mice.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Down-Regulation; Hallucinogens; Haloperidol; Lysergic Acid Diethylamide; Male; Mice; Mice, 129 Strain; Psychotic Disorders; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Agonists; Time Factors | 2013 |
Differential effects of antipsychotics on lateral bias and social attention in female rats.
Topics: Animals; Antipsychotic Agents; Attention; Behavior, Animal; Clozapine; Disease Models, Animal; Female; Functional Laterality; Haloperidol; Rats; Rats, Long-Evans; Social Behavior; Sulpiride | 2013 |
The sex-dependent impact of chronic clozapine and haloperidol treatment on characteristics of the metabolic syndrome in a rat model.
Topics: Adiposity; Animals; Antipsychotic Agents; Blood Glucose; Body Weight; Clozapine; Drinking; Eating; Female; Haloperidol; Hormones; Insulin; Lipids; Male; Metabolic Syndrome; Motor Activity; Rats; Rats, Sprague-Dawley; Sex Characteristics; Weight Gain | 2013 |
Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier.
Topics: Anion Transport Proteins; Antipsychotic Agents; Cell Line; Clozapine; Diabetes Mellitus; Gene Expression Regulation; Gene Silencing; Glucose; Haloperidol; Hep G2 Cells; Hepatocyte Nuclear Factor 3-alpha; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mitochondrial Proteins; Organic Anion Transporters; Promoter Regions, Genetic; Recombinant Proteins; Response Elements; RNA, Messenger; RNA, Small Interfering; Up-Regulation | 2013 |
Two-dimensional gel electrophoresis revealed antipsychotic drugs induced protein expression modulations in C6 glioma cells.
Topics: Animals; Antipsychotic Agents; Cell Line, Tumor; Clozapine; Electrophoresis, Gel, Two-Dimensional; Frontal Lobe; Gene Expression; Glioma; Haloperidol; Rats; Risperidone; Time Factors | 2013 |
Aquaporin-4 knockout abolishes apomorphine-induced tardive dyskinesia following chronic treatment with neuroleptics.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Antipsychotic Agents; Apomorphine; Aquaporin 4; Clozapine; Corpus Striatum; Disease Models, Animal; Glial Fibrillary Acidic Protein; Haloperidol; Hippocampus; Male; Mastication; Mice; Mice, Knockout; Motor Activity; Movement Disorders | 2012 |
Clozapine regulation of p90RSK and c-Fos signaling via the ErbB1-ERK pathway is distinct from olanzapine and haloperidol in mouse cortex and striatum.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Clozapine; Corpus Striatum; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Haloperidol; Mice; Olanzapine; Phosphorylation; Proto-Oncogene Proteins c-fos; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction | 2013 |
Haloperidol-induced striatal Nur77 expression in a non-human primate model of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Cebus; Clozapine; Corpus Striatum; Female; Haloperidol; Movement Disorders; Nuclear Receptor Subfamily 4, Group A, Member 1; Putamen; RNA, Messenger; Transcription, Genetic; Up-Regulation | 2013 |
The effects of ziprasidone, clozapine and haloperidol on lipid peroxidation in human plasma (in vitro): comparison.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; In Vitro Techniques; Lipid Peroxidation; Male; Piperazines; Thiazoles; Thiobarbituric Acid Reactive Substances | 2013 |
Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1.
Topics: Adenosine A2 Receptor Antagonists; Aminoacetonitrile; Animals; Clozapine; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; GABA Antagonists; Gene Expression Regulation; Haloperidol; In Vitro Techniques; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Mutation; Phosphorylation; Protease Inhibitors; Protein Phosphatase 1; Purines; Ribosomal Protein S6; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Prefrontal cortical dysfunction after overexpression of histone deacetylase 1.
Topics: Animals; Astrocytes; Clozapine; Down-Regulation; Exploratory Behavior; Genes, MHC Class II; Haloperidol; Histocompatibility Antigens Class II; Histone Deacetylase 1; Memory, Long-Term; Memory, Short-Term; Mice; Mice, Transgenic; Neurons; Prefrontal Cortex; Stereotyped Behavior; Transcriptome; Up-Regulation | 2013 |
Administration of the Y2 receptor agonist PYY3-36 in mice induces multiple behavioral changes relevant to schizophrenia.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine Antagonists; Haloperidol; Inhibition, Psychological; Male; Maze Learning; Mice; Mice, Inbred C57BL; Peptide Fragments; Peptide YY; Receptors, Neuropeptide Y; Schizophrenia; Social Behavior | 2013 |
Conserved chromosome 2q31 conformations are associated with transcriptional regulation of GAD1 GABA synthesis enzyme and altered in prefrontal cortex of subjects with schizophrenia.
Topics: Animals; Antipsychotic Agents; Cells, Cultured; Chromosomes, Human, Pair 2; Clozapine; DNA Methylation; Down-Regulation; Fibroblasts; Gene Expression Regulation; Glutamate Decarboxylase; Haloperidol; Hippocampus; Histones; Humans; Mice; Mice, Transgenic; Neurons; Prefrontal Cortex; Schizophrenia | 2013 |
Co-administration of 5-HT6 receptor antagonists with clozapine, risperidone, and a 5-HT2A receptor antagonist: effects on prepulse inhibition in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Data Interpretation, Statistical; Dizocilpine Maleate; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Fluorobenzenes; Haloperidol; Male; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reflex, Startle; Risperidone; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Sulfonamides; Thiophenes | 2014 |
Cerebellar motor learning deficits in medicated and medication-free men with recent-onset schizophrenia.
Topics: Adaptation, Psychological; Adolescent; Adult; Antipsychotic Agents; Blinking; Cerebellum; Clozapine; Conditioning, Eyelid; Haloperidol; Humans; Learning; Male; Motor Activity; Saccades; Schizophrenia; Schizophrenic Psychology; Time Factors; Young Adult | 2014 |
Pharmacoeconomics of depot antipsychotics for treating chronic schizophrenia in Sweden.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Cost of Illness; Cost-Benefit Analysis; Delayed-Action Preparations; Drug Costs; Female; Haloperidol; Health Care Costs; Hospitalization; Humans; Isoxazoles; Male; Middle Aged; Models, Econometric; Olanzapine; Paliperidone Palmitate; Palmitates; Quality-Adjusted Life Years; Risperidone; Schizophrenia; Sweden | 2014 |
The comparative effects of clozapine versus haloperidol on initiation and maintenance of alcohol drinking in male alcohol-preferring P rat.
Topics: Alcohol Drinking; Alcoholism; Animals; Antipsychotic Agents; Body Weight; Clozapine; Dose-Response Relationship, Drug; Drinking; Eating; Haloperidol; Male; Rats; Rats, Inbred Strains | 2013 |
Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor.
Topics: Animals; Antipsychotic Agents; Benzazepines; Butyric Acid; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Clozapine; Dopamine Antagonists; Epigenesis, Genetic; Exploratory Behavior; Hallucinogens; Haloperidol; Histamine Antagonists; Histone Deacetylases; Histones; Male; Memory Disorders; Mice; Mice, Inbred ICR; Phencyclidine; Phencyclidine Abuse; Prefrontal Cortex; Receptors, Dopamine D1 | 2014 |
Dissociable effects of antipsychotics on ketamine-induced changes in regional oxygenation and inter-regional coherence of low frequency oxygen fluctuations in the rat.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Area Under Curve; Brain; Clozapine; Disease Models, Animal; Dissociative Disorders; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Ketamine; Male; Oxygen; Rats; Tissue Distribution | 2014 |
Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes.
Topics: Antipsychotic Agents; Cell Culture Techniques; Chlorpromazine; Clozapine; Gene Expression; Haloperidol; Humans; Jurkat Cells; Microarray Analysis; MicroRNAs; Real-Time Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes | 2014 |
Evaluation of the potential of antipsychotic agents to induce catalepsy in rats: assessment of a new, commercially available, semi-automated instrument.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Catalepsy; Clozapine; Haloperidol; Hand Strength; Male; Olanzapine; Posture; Psychology, Experimental; Rats; Rats, Sprague-Dawley | 2014 |
Effects of the nicotinic α7 receptor partial agonist GTS-21 on NMDA-glutamatergic receptor related deficits in sensorimotor gating and recognition memory in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Apomorphine; Benzylidene Compounds; Clozapine; Cognition; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Antagonists; Haloperidol; Male; Nicotinic Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Recognition, Psychology; Reflex, Startle; Sensory Gating | 2014 |
Association between the brain-derived neurotrophic factor Val66Met polymorphism and therapeutic response to olanzapine in schizophrenia patients.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Brain-Derived Neurotrophic Factor; Clozapine; Female; Genetic Association Studies; Genotype; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Pharmacogenetics; Polymorphism, Single Nucleotide; Predictive Value of Tests; Risperidone; Schizophrenia; Treatment Outcome | 2014 |
The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs.
Topics: Amino Acids; Animals; Antipsychotic Agents; Banisteriopsis; Brain Waves; Bridged Bicyclo Compounds, Heterocyclic; Clozapine; Excitatory Amino Acid Agonists; Functional Neuroimaging; Hallucinogens; Haloperidol; Magnetic Resonance Imaging; Male; Methoxydimethyltryptamines; Prefrontal Cortex; Pyramidal Cells; Rats; Risperidone; Visual Cortex | 2014 |
Schizophrenia and co-occurring substance use disorder: reward, olfaction and clozapine.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Fluphenazine; Haloperidol; Humans; Male; Middle Aged; Odorants; Psychiatric Status Rating Scales; Reward; Schizophrenia; Schizophrenic Psychology; Smell; Substance-Related Disorders | 2014 |
Upregulation of dopamine D3, not D2, receptors correlates with tardive dyskinesia in a primate model.
Topics: Animals; Antipsychotic Agents; Brain; Cebus; Clozapine; Disease Models, Animal; Dopamine Antagonists; Enkephalins; Female; Haloperidol; Iodine Radioisotopes; Movement Disorders; Neurons; Ovariectomy; Protein Binding; Receptors, Dopamine D2; Receptors, Dopamine D3; Sulpiride; Tetrahydronaphthalenes; Up-Regulation | 2014 |
Haloperidol treatment downregulates DCC expression in the ventral tegmental area.
Topics: Animals; Antipsychotic Agents; Clozapine; DCC Receptor; Dose-Response Relationship, Drug; Down-Regulation; Haloperidol; Male; Mice, Inbred C57BL; Netrin Receptors; Receptors, Cell Surface; Risperidone; Time Factors; Tumor Suppressor Proteins; Ventral Tegmental Area | 2014 |
Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR).
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; DNA Methylation; Gene Expression; Haloperidol; Male; Neurotransmitter Agents; Nucleus Accumbens; Prefrontal Cortex; Promoter Regions, Genetic; Rats, Inbred SHR; Risperidone; Schizophrenia | 2014 |
Effect of environmental cues on the behavioral efficacy of haloperidol, olanzapine, and clozapine in rats.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Cues; Drug Tolerance; Environment; Excitatory Amino Acid Antagonists; Haloperidol; Housing, Animal; Hyperkinesis; Male; Motor Activity; Olanzapine; Phencyclidine; Random Allocation; Rats, Sprague-Dawley | 2014 |
Examining dopamine D3 receptor occupancy by antipsychotic drugs via [3H]7-OH-DPAT ex vivo autoradiography and its cross-validation via c-fos immunohistochemistry in the rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Clozapine; Dopamine Antagonists; Haloperidol; Indoles; Islands of Calleja; Male; Nitriles; Olanzapine; Piperidines; Proto-Oncogene Proteins c-fos; Radiography; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydroisoquinolines; Tetrahydronaphthalenes | 2014 |
Chronic administration of haloperidol and clozapine induces differential effects on the expression of Arc and c-Fos in rat brain.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Corpus Striatum; Cytoskeletal Proteins; Gene Expression Regulation; Gyrus Cinguli; Haloperidol; Male; Nerve Tissue Proteins; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Septum of Brain; Time Factors | 2014 |
Sex-dependent metabolic alterations of rat liver after 12-week exposition to haloperidol or clozapine.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Biomarkers; Cholesterol, HDL; Clozapine; Female; Glucose; Glycogen; Haloperidol; Liver; Male; Malondialdehyde; Organ Size; Oxidative Stress; Rats, Sprague-Dawley; Sex Characteristics; Sterol Regulatory Element Binding Proteins; Triglycerides | 2014 |
Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2)-deficient mice: do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine D2 Receptor Antagonists; Haloperidol; Inhibition, Psychological; Learning; Mice; Mice, Knockout; Receptors, Dopamine D1; Receptors, Dopamine D2 | 2014 |
Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier.
Topics: Antipsychotic Agents; Apoptosis; Blood-Brain Barrier; Capillary Permeability; Caspase 3; Caspase 8; Caspase 9; Cell Survival; Cells, Cultured; Chlorpromazine; Clozapine; DNA Breaks; Endothelial Cells; Haloperidol; Humans; Microvessels; Oxidative Stress; Reactive Oxygen Species; Risperidone | 2014 |
Involvement of glutamatergic and GABAergic transmission in MK-801-increased gamma band oscillation power in rat cortical electroencephalograms.
Topics: Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Excitatory Amino Acid Antagonists; Fluorobenzenes; GABA Agents; Gamma Rhythm; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Male; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Riluzole; Triazoles | 2014 |
Prefrontal cortical dendritic spine pathology in schizophrenia and bipolar disorder.
Topics: Animals; Atrophy; Bipolar Disorder; Case-Control Studies; Clozapine; Dendritic Spines; Female; Frontal Lobe; Haloperidol; Humans; Male; Middle Aged; Prefrontal Cortex; Pyramidal Cells; Rats; Schizophrenia | 2014 |
Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Glycine; Glycine Plasma Membrane Transport Proteins; Haloperidol; Imipramine; Locomotion; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia; Serine; Swimming | 2015 |
A systematic microdialysis study of dopamine transmission in the accumbens shell/core and prefrontal cortex after acute antipsychotics.
Topics: Administration, Intravenous; Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Dopamine; Haloperidol; Male; Microdialysis; Nucleus Accumbens; Prefrontal Cortex; Raclopride; Rats; Rats, Sprague-Dawley; Risperidone; Time Factors | 2015 |
Involvement of cholinergic system in hyperactivity in dopamine-deficient mice.
Topics: Acetylcholine; Akathisia, Drug-Induced; Animals; Anti-Dyskinesia Agents; Antipsychotic Agents; Central Nervous System Stimulants; Choline O-Acetyltransferase; Clozapine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Extracellular Space; Haloperidol; Levodopa; Locomotion; Mice, Inbred C57BL; Piperazines; Psychomotor Agitation; Thiazoles | 2015 |
Differential effects of clozapine, metoclopramide, haloperidol and risperidone on acquisition and performance of operant responding in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Conditioning, Operant; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Metoclopramide; Prefrontal Cortex; Rats; Rats, Wistar; Risperidone | 2015 |
Comparative analysis of the treatment of chronic antipsychotic drugs on epileptic susceptibility in genetically epilepsy-prone rats.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Disease Models, Animal; Epilepsy; Haloperidol; Mental Disorders; Olanzapine; Quetiapine Fumarate; Rats; Risperidone; Seizures | 2015 |
Regulation of neutrophil phagocytosis of Escherichia coli by antipsychotic drugs.
Topics: Antipsychotic Agents; Blotting, Western; Clozapine; Escherichia coli; Haloperidol; HL-60 Cells; Humans; Interleukin-8; Macrophage-1 Antigen; Neutrophils; Peroxidase; Phagocytosis; Risperidone | 2014 |
Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Haloperidol; Lipid Peroxidation; Liver; Male; Organ Specificity; Oxidation-Reduction; Oxidative Stress; Peroxiredoxins; Rats, Sprague-Dawley; Serum | 2015 |
Impramine, fluoxetine and clozapine differently affected reactivity to positive and negative stimuli in a model of motivational anhedonia in rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Antipsychotic Agents; Clozapine; Dietary Sucrose; Disease Models, Animal; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Eating; Fluoxetine; Haloperidol; Imipramine; Lithium Compounds; Male; Motivation; Nucleus Accumbens; Phosphorylation; Rats, Sprague-Dawley; Stress, Psychological | 2015 |
Are reduplicative paramnesia and clonal pluralization overlapping constructs?
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Capgras Syndrome; Clozapine; Diagnosis, Differential; Haloperidol; Humans; Identification, Psychological; Male; Olanzapine; Psychiatric Status Rating Scales; Schizophrenia, Paranoid; Treatment Outcome | 2015 |
Inhibition of 14-3-3 Proteins Leads to Schizophrenia-Related Behavioral Phenotypes and Synaptic Defects in Mice.
Topics: 14-3-3 Proteins; Animals; Antipsychotic Agents; Behavior, Animal; Catenins; Cerebral Cortex; Clozapine; Cofilin 1; Delta Catenin; Dendrites; Disease Models, Animal; Dopamine; Haloperidol; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Prepulse Inhibition; Proteins; Receptors, Dopamine; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2015 |
Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor.
Topics: Antipsychotic Agents; Aripiprazole; Cell Membrane; Clozapine; Corpus Striatum; Dopamine Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; HEK293 Cells; Humans; Kinetics; Piperazines; Radioligand Assay; Receptors, Dopamine D2; Transfection | 2015 |
Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Adult; Alcohol Drinking; Animals; Clozapine; Desipramine; Dose-Response Relationship, Drug; Drug Synergism; Eating; Female; Haloperidol; Humans; Idazoxan; Male; Mesocricetus; Receptors, Dopamine D2 | 2015 |
A Methionine-Induced Animal Model of Schizophrenia: Face and Predictive Validity.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Depression; Disease Models, Animal; Haloperidol; Male; Methionine; Mice; Motor Activity; Pain Threshold; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Sensory Gating; Social Behavior; Stereotyped Behavior; Treatment Outcome | 2015 |
AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes.
Topics: Adult; Animals; Antipsychotic Agents; Behavior, Animal; Blotting, Western; Brain; Cell Membrane; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Genetic Predisposition to Disease; Haloperidol; Heat-Shock Proteins; Hippocampus; Humans; Immunohistochemistry; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Knockout; Middle Aged; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptide Fragments; Phenotype; Schizophrenia; Serotonin; Shab Potassium Channels; Young Adult | 2016 |
Low expression of Gria1 and Grin1 glutamate receptors in the nucleus accumbens of Spontaneously Hypertensive Rats (SHR).
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Gene Expression; Glycine Plasma Membrane Transport Proteins; Haloperidol; Male; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Inbred SHR; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; Risperidone; Schizophrenia | 2015 |
Effects of long-term treatment with the neuroleptics haloperidol, clozapine and olanzapine on immunoexpression of NMDA receptor subunits NR1, NR2A and NR2B in the rat hippocampus.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Clozapine; Dentate Gyrus; Haloperidol; Hippocampus; Male; Olanzapine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2015 |
Effects of NMDA receptor antagonists and antipsychotics on high frequency oscillations recorded in the nucleus accumbens of freely moving mice.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Haloperidol; Ketamine; Male; Mice; Nucleus Accumbens; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2015 |
LASSBio-579, a prototype antipsychotic drug, and clozapine are effective in novel object recognition task, a recognition memory model.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Haloperidol; Ketamine; Male; Memory, Long-Term; Memory, Short-Term; Mice; Piperazines; Recognition, Psychology; Schizophrenia; Time Factors | 2016 |
Examination of clozapine and haloperidol in improving ketamine-induced deficits in an incremental repeated acquisition procedure in BALB/c mice.
Topics: Algorithms; Animals; Antipsychotic Agents; Clozapine; Cognition; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Haloperidol; Ketamine; Male; Mice; Mice, Inbred BALB C; Psychomotor Performance | 2016 |
Ligand Binding Pathways of Clozapine and Haloperidol in the Dopamine D2 and D3 Receptors.
Topics: Clozapine; Haloperidol; Ligands; Molecular Dynamics Simulation; Protein Binding; Receptors, Dopamine D2; Receptors, Dopamine D3 | 2016 |
Higher serum concentrations of tyrosine and glutamate in schizophrenia patients treated with clozapine, compared to in those treated with conventional antipsychotics.
Topics: Adult; Amino Acids; Antipsychotic Agents; Chromatography, Ion Exchange; Clopenthixol; Clozapine; Cohort Studies; Female; Glutamic Acid; Haloperidol; Humans; Insulin Resistance; Male; Middle Aged; Perphenazine; Prospective Studies; Psychotic Disorders; Schizophrenia; Thioridazine; Tyrosine | 2015 |
NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Brain; Cell Count; Clozapine; Female; Flow Cytometry; Gray Matter; Haloperidol; Immunohistochemistry; Macaca; Magnetic Resonance Imaging; Male; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Oligodendroglia; Organ Size; Random Allocation; White Matter | 2016 |
In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy.
Topics: Animals; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B; Benzodiazepines; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Clozapine; Haloperidol; Male; Neuropharmacology; Olanzapine; Paliperidone Palmitate; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Risperidone | 2016 |
Antipsychotic Drugs Differentially Affect mRNA Expression of Genes Encoding the Neuregulin 1-Downstream ErbB4-PI3K Pathway.
Topics: Amisulpride; Antipsychotic Agents; Benzodiazepines; Cell Line, Tumor; Cell Survival; Clozapine; Gene Expression Regulation; Haloperidol; Humans; Neuregulin-1; Olanzapine; Phosphatidylinositol 3-Kinases; Quetiapine Fumarate; Receptor, ErbB-4; RNA, Messenger; Schizophrenia; Sulpiride | 2016 |
Effects of prolonged antipsychotic administration on neuregulin-1/ErbB signaling in rat prefrontal cortex and myocardium: implications for the therapeutic action and cardiac adverse effect.
Topics: Animals; Antipsychotic Agents; Cardiovascular Diseases; Clozapine; Comorbidity; Genetic Predisposition to Disease; Haloperidol; Injections, Intraperitoneal; Male; Myocardium; Neuregulin-1; Phosphorylation; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, ErbB-2; Receptor, ErbB-4; Risk; Risperidone; Schizophrenia; Signal Transduction; Time Factors | 2016 |
Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia.
Topics: Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Female; Haloperidol; Humans; Immunoprecipitation; Male; Mass Spectrometry; Middle Aged; Protein Isoforms; Rats, Sprague-Dawley; Schizophrenia; Synaptosomal-Associated Protein 25 | 2016 |
[Plasma levels of antipsychotics and the severity of side-effects in the treatment of schizophrenia exacerbation].
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Blood Glucose; Clozapine; Depression; Drug Therapy, Combination; Female; Haloperidol; Humans; Hyperprolactinemia; Male; Middle Aged; Olanzapine; Prolactin; Risperidone; Schizophrenia; Schizophrenic Psychology; Young Adult | 2015 |
Dopamine dynamics during emotional cognitive processing: Implications of the specific actions of clozapine compared with haloperidol.
Topics: Amygdala; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Cognition; Conditioning, Psychological; Cues; Dopamine; Emotions; Extracellular Space; Fear; Haloperidol; Male; Methamphetamine; Rats; Rats, Sprague-Dawley | 2016 |
Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine.
Topics: Amino Acids; Animals; Antipsychotic Agents; Benzodiazepines; Bridged Bicyclo Compounds, Heterocyclic; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Haloperidol; Ketamine; Male; Olanzapine; Prepulse Inhibition; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia | 2016 |
Modulation of glycine sites enhances social memory in rats using PQQ combined with d-serine.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Drug Contamination; Drug Synergism; Glycine; Haloperidol; Male; Memory; Memory Disorders; Neuroprotective Agents; PQQ Cofactor; Rats; Rats, Sprague-Dawley; Serine; Social Behavior; Time Factors | 2016 |
Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Autoradiography; Binding Sites; Brain; Clozapine; Female; Gene Expression; Haloperidol; Humans; Male; Middle Aged; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Oxytocin; RNA, Messenger; Schizophrenia | 2016 |
Clozapine and olanzapine are better antioxidants than haloperidol, quetiapine, risperidone and ziprasidone in in vitro models.
Topics: Antioxidants; Antipsychotic Agents; Benzodiazepines; Biphenyl Compounds; Clozapine; Free Radical Scavengers; Haloperidol; Humans; Models, Biological; Neutrophil Activation; Neutrophils; Olanzapine; Picrates; Piperazines; Quetiapine Fumarate; Reactive Oxygen Species; Risperidone; Tetradecanoylphorbol Acetate; Thiazoles | 2016 |
Extended neuroleptic administration modulates NMDA-R subunit immunoexpression in the rat neocortex and diencephalon.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Clozapine; Diencephalon; Down-Regulation; Haloperidol; Hippocampus; Hypothalamus; Male; N-Methylaspartate; Neocortex; Olanzapine; Protein Subunits; Rats; Rats, Sprague-Dawley; Up-Regulation | 2016 |
Effects of Antipsychotic Drugs Haloperidol and Clozapine on Visual Responses of Retinal Ganglion Cells in a Rat Model of Retinitis Pigmentosa.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Haloperidol; Rats; Retinal Ganglion Cells; Retinitis Pigmentosa | 2016 |
Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice.
Topics: Animals; Antioxidants; Behavior, Animal; Cell Nucleus; Clozapine; DNA; Glutamate-Cysteine Ligase; Glutathione; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Glutathione Reductase; Haloperidol; Lipid Peroxidation; Male; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidation-Reduction; Phencyclidine; Prefrontal Cortex; Reactive Oxygen Species; RNA, Messenger; Social Behavior; Superoxide Dismutase; Time Factors; Transcription Factor RelA | 2017 |
Exploiting heterogeneous publicly available data sources for drug safety surveillance: computational framework and case studies.
Topics: Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Cardiotoxicity; Cerebral Hemorrhage; Clozapine; Drug-Related Side Effects and Adverse Reactions; Factor Xa Inhibitors; Haloperidol; Humans; Information Storage and Retrieval; Pharmacovigilance; Pyrazoles; Pyridones | 2017 |
Sedative effect of Clozapine is a function of 5-HT
Topics: Animals; Antipsychotic Agents; Caffeine; Central Nervous System Stimulants; Clozapine; Dose-Response Relationship, Drug; Environment; Exploratory Behavior; Genotype; Haloperidol; Inhibition, Psychological; Mice; Mice, Knockout; Receptor, Serotonin, 5-HT2A; Risperidone; Serotonin Antagonists | 2017 |
Time to Discontinuation of Second-Generation Antipsychotics Versus Haloperidol and Sulpiride in People With Schizophrenia: A Naturalistic, Comparative Study.
Topics: Adult; Antipsychotic Agents; Clozapine; Female; Haloperidol; Humans; Male; Medication Adherence; Retrospective Studies; Schizophrenia; Sulpiride; Taiwan; Time Factors; Young Adult | 2017 |
Effects of antipsychotics on intestinal motility in zebrafish larvae.
Topics: Animals; Antipsychotic Agents; Atropine; Clozapine; Drug Evaluation, Preclinical; Gastrointestinal Motility; Gastrointestinal Tract; Haloperidol; Larva; Muscarinic Antagonists; Risperidone; Zebrafish | 2017 |
Differential effects of antipsychotic and propsychotic drugs on prepulse inhibition and locomotor activity in Roman high- (RHA) and low-avoidance (RLA) rats.
Topics: Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Clozapine; Dizocilpine Maleate; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Locomotion; Male; Prepulse Inhibition; Rats; Receptor, Serotonin, 5-HT2A; Reflex, Startle; Schizophrenia; Serotonin 5-HT2 Receptor Agonists; Serotonin Antagonists | 2017 |
Effect of psychotropic drug treatment on sterol metabolism.
Topics: Adult; Animals; Antidepressive Agents; Antipsychotic Agents; Body Mass Index; Cholestadienols; Clozapine; Dehydrocholesterols; Female; Haloperidol; Humans; Lipid Metabolism; Male; Mental Disorders; Psychiatric Status Rating Scales; Random Allocation; Rats, Sprague-Dawley; Weight Gain | 2017 |
A drug-drug conditioning paradigm reveals multiple antipsychotic-nicotine interactions.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Conditioning, Classical; Conditioning, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Motor Activity; Nicotine; Rats; Rats, Sprague-Dawley; Schizophrenia | 2017 |
Time-dependent sensitization of antipsychotic effect in adolescent male and female rats.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Clozapine; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Female; Haloperidol; Male; Motor Activity; Olanzapine; Phencyclidine; Random Allocation; Rats, Sprague-Dawley; Sex Characteristics; Time Factors | 2017 |
Pharmacoepigenomic responses of antipsychotic drugs on pharmacogenes are likely to be modulated by miRNAs.
Topics: Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B; Benzodiazepines; Case-Control Studies; Clozapine; Cytochrome P-450 CYP3A; Epigenesis, Genetic; Haloperidol; Hep G2 Cells; Humans; MicroRNAs; Olanzapine; Promoter Regions, Genetic; Schizophrenia | 2017 |
The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression.
Topics: Affect; Animals; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Cell Survival; Clozapine; Depression; Disease Models, Animal; Haloperidol; Hippocampus; Male; Neurogenesis; Neuronal Plasticity; Prefrontal Cortex; Rats; Rats, Wistar; Swimming | 2017 |
Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens.
Topics: Adenosine Triphosphate; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Haloperidol; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potassium Chloride; Random Allocation; Serotonin; Vas Deferens | 2017 |
The role of oxidative stress in antipsychotics induced ovarian toxicity.
Topics: Animals; Antipsychotic Agents; Caspases; Cell Survival; Cells, Cultured; Chlorpromazine; Clozapine; Female; Glutathione; Haloperidol; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Risperidone; Theca Cells | 2017 |
Deficient striatal adaptation in aminergic and glutamatergic neurotransmission is associated with tardive dyskinesia in non-human primates exposed to antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Female; Haloperidol; Haplorhini; Putamen; Tardive Dyskinesia | 2017 |
Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits.
Topics: Animals; Antipsychotic Agents; Basic Helix-Loop-Helix Transcription Factors; CA1 Region, Hippocampal; Clozapine; Developmental Disabilities; Disease Models, Animal; Female; Folic Acid; Haloperidol; Humans; Male; Methionine; Mice; Neurogenesis; Neuronal Plasticity; One-Carbon Group Transferases; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Schizophrenia; Stereotyped Behavior; Tetrahydrofolates | 2018 |
Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Bromodeoxyuridine; Cell Count; Clozapine; Haloperidol; Hippocampus; Immunohistochemistry; Male; Mice, Inbred C57BL; Neurogenesis; Neurons; Olanzapine; Quetiapine Fumarate | 2017 |
Periodic catatonia with long-term treatment: a case report.
Topics: Antipsychotic Agents; Catatonia; Clozapine; Drug Therapy, Combination; Female; Haloperidol; Humans; Loxapine; Middle Aged; Risperidone; Schizophrenia | 2017 |
Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine.
Topics: Animals; Antipsychotic Agents; Bone and Bones; Bone Density; Clozapine; Corticosterone; Female; Haloperidol; Interleukin-6; Male; Phencyclidine; Rats, Wistar; Schizophrenia; Sex Characteristics; Tumor Necrosis Factor-alpha | 2017 |
Understanding the influence of antipsychotic drugs on global methylation events and its relevance in treatment response.
Topics: 5-Methylcytosine; Adult; Antipsychotic Agents; Case-Control Studies; Clozapine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Female; Haloperidol; Hep G2 Cells; Humans; Male; MicroRNAs; Olanzapine; Pharmacogenetics; Schizophrenia; Treatment Outcome | 2018 |
Effects of haloperidol and clozapine on synapse-related gene expression in specific brain regions of male rats.
Topics: Animals; Antipsychotic Agents; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cerebral Cortex; Clozapine; Dentate Gyrus; Gene Expression; Gene Expression Regulation; Gyrus Cinguli; Haloperidol; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Synaptosomal-Associated Protein 25; Syntaxin 1 | 2018 |
Reduced cardiovascular fitness associated with exposure to clozapine in individuals with chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Cardiovascular Diseases; Chronic Disease; Clozapine; Cross-Sectional Studies; Female; Haloperidol; Humans; Male; Oxygen Consumption; Physical Fitness; Schizophrenia | 2018 |
Predictors of remission during acute treatment of first-episode schizophrenia patients involuntarily hospitalized and treated with algorithm-based pharmacotherapy: Secondary analysis of an observational study.
Topics: Administration, Oral; Adult; Algorithms; Antipsychotic Agents; Clozapine; Commitment of Mentally Ill; Drug Therapy, Combination; Female; Haloperidol; Humans; Injections, Intramuscular; Male; Methotrimeprazine; Olanzapine; Psychotic Disorders; Quetiapine Fumarate; Retrospective Studies; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Failure; Treatment Outcome | 2019 |
Effects of the antipsychotics haloperidol, clozapine, and aripiprazole on the dendritic spine.
Topics: Animals; Aripiprazole; Cerebral Cortex; Clozapine; Dendritic Spines; Disks Large Homolog 4 Protein; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta; Haloperidol; Indoles; Maleimides; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2018 |
Clozapine reduces nicotine self-administration, blunts reinstatement of nicotine-seeking but increases responding for food.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Conditioning, Operant; Drug-Seeking Behavior; Food; Haloperidol; Male; Motivation; Nicotine; Nicotinic Agonists; Rats; Reward; Self Administration | 2019 |
Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mice, Inbred C57BL; Mice, Knockout; Receptors, Dopamine D2 | 2018 |
Clozapine toxicity in a CYP2D6 poor metaboliser: Additive effects of haloperidol and valproate on clozapine metabolism.
Topics: Adult; Antipsychotic Agents; Clozapine; Cytochrome P-450 CYP2D6; Drug Synergism; Haloperidol; Humans; Male; Schizophrenia; Valproic Acid; Young Adult | 2018 |
Impact of nuclear distribution element genes in the typical and atypical antipsychotics effects on nematode Caenorhabditis elegans: Putative animal model for studying the pathways correlated to schizophrenia.
Topics: Animals; Animals, Genetically Modified; Antipsychotic Agents; Behavior, Animal; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; Clozapine; Disease Models, Animal; Haloperidol; Movement; Neurotransmitter Agents; Pharynx; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results; Reproduction; Schizophrenia; Serotonin | 2019 |
Tardive dyskinesia is associated with altered putamen Akt/GSK-3β signaling in nonhuman primates.
Topics: Animals; beta-Arrestin 2; Cebus; Clozapine; Dopamine and cAMP-Regulated Phosphoprotein 32; G-Protein-Coupled Receptor Kinases; Glycogen Synthase Kinase 3 beta; Haloperidol; MAP Kinase Signaling System; Phosphorylation; Proto-Oncogene Proteins c-akt; Putamen; Receptors, Dopamine D3; Signal Transduction; Tardive Dyskinesia | 2019 |
Prenatal treatment with methylazoxymethanol acetate as a neurodevelopmental disruption model of schizophrenia in mice.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Clozapine; Disease Models, Animal; Female; Haloperidol; Hippocampus; Methylazoxymethanol Acetate; Mice; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Risperidone; Schizophrenia | 2019 |
Chronic Antipsychotic Treatment Modulates Aromatase (CYP19A1) Expression in the Male Rat Brain.
Topics: Animals; Antipsychotic Agents; Aromatase; Brain; Clozapine; Haloperidol; Male; Olanzapine; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2019 |
Discriminative stimulus properties of the typical antipsychotic haloperidol compared to other antipsychotic drugs in C57BL/6 mice.
Topics: Amisulpride; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Mice, Inbred C57BL | 2019 |
Role of D3 dopamine receptors in modulating neuroanatomical changes in response to antipsychotic administration.
Topics: Animals; Antipsychotic Agents; Cell Count; Clozapine; Corpus Striatum; Female; Gyrus Cinguli; Haloperidol; Humans; Injections, Intraperitoneal; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mice; Mice, Knockout; Models, Animal; Neuroglia; Neurons; Organ Size; Psychotic Disorders; Receptors, Dopamine D3; Schizophrenia | 2019 |
Differential effects of antipsychotic drugs on contrast response functions of retinal ganglion cells in wild-type Sprague-Dawley rats and P23H retinitis pigmentosa rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Haloperidol; Male; Photic Stimulation; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Retinitis Pigmentosa | 2019 |
D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice.
Topics: Animals; Benzazepines; Clozapine; Dopamine D2 Receptor Antagonists; Haloperidol; Hippocampus; Male; Mice; Mice, Transgenic; MicroRNAs; Motor Activity; Neuregulin-1; Phencyclidine; Prefrontal Cortex; Primary Cell Culture; Quinpirole; Receptors, Dopamine D2; Salicylamides | 2019 |
Effect fingerprints of antipsychotic drugs on neural networks in vitro.
Topics: Action Potentials; Animals; Animals, Newborn; Antipsychotic Agents; Aripiprazole; Cells, Cultured; Cerebral Cortex; Clozapine; Dose-Response Relationship, Drug; Haloperidol; Mice; Mice, Inbred C57BL; Nerve Net | 2019 |
The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine-a histological and biochemical study in albino rats.
Topics: Animals; Catalase; Clozapine; Female; Glutathione; Haloperidol; Mitochondria; Ovary; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2019 |
Asenapine maleate normalizes low frequency oscillatory deficits in a neurodevelopmental model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Delta Rhythm; Dibenzocycloheptenes; Disease Models, Animal; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Rats; Rats, Sprague-Dawley; Schizophrenia | 2019 |
Pharmacological and proteomic analyses of neonatal polyI:C-treated adult mice.
Topics: Aldehyde Dehydrogenase 1 Family; Animals; Animals, Newborn; Antipsychotic Agents; Clozapine; Disease Models, Animal; Exploratory Behavior; Female; Haloperidol; Hippocampus; Hydrolases; Interpersonal Relations; Mice; Microtubule-Associated Proteins; Nerve Tissue Proteins; Poly I-C; Pregnancy; Prepulse Inhibition; Proteomics; Recognition, Psychology; Schizophrenia; Sensory Gating | 2019 |
Risk Factors for Noncompliance with Antipsychotic Medication in Long-Term Treated Chronic Schizophrenia Patients.
Topics: Antipsychotic Agents; Clozapine; Haloperidol; Humans; Olanzapine; Patient Compliance; Risk Factors; Schizophrenia; Schizophrenic Psychology | 2019 |
Clozapine protects adult neural stem cells from ketamine-induced cell death in correlation with decreased apoptosis and autophagy.
Topics: Adult Stem Cells; Animals; Apoptosis; Autophagy; Caspase 3; Cells, Cultured; Clozapine; Excitatory Amino Acid Antagonists; Haloperidol; Ketamine; Lateral Ventricles; Male; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neural Stem Cells; Neurogenesis; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Signal Transduction | 2020 |
Development of an Integrated Tissue Pretreatment Protocol for Enhanced MALDI MS Imaging of Drug Distribution in the Brain.
Topics: Animals; Aripiprazole; Brain; Brain Chemistry; Central Nervous System Agents; Clozapine; Donepezil; Haloperidol; Male; Mice; Mice, Inbred C57BL; Peritoneum; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tacrine; Tissue Distribution | 2020 |
Sex-dependent alterations of dopamine receptor and glucose transporter density in rat hypothalamus under long-term clozapine and haloperidol medication.
Topics: Animals; Clozapine; Endothelial Cells; Female; Glucose Transport Proteins, Facilitative; Haloperidol; Hypothalamus; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine | 2020 |
Effects of treatment with haloperidol and clozapine on the plasma concentrations of thyroid hormones in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Thyroxine; Triiodothyronine | 2020 |
Ubiquitin-proteasome system, lipid metabolism and DNA damage repair are triggered by antipsychotic medication in human oligodendrocytes: implications in schizophrenia.
Topics: Antipsychotic Agents; Cells, Cultured; Clozapine; DNA Damage; DNA Repair; Haloperidol; Humans; Lipid Metabolism; Oligodendroglia; Proteasome Endopeptidase Complex; Proteome; Schizophrenia | 2020 |
Antipsychotics inhibit the mitochondrial bioenergetics of pancreatic beta cells isolated from CD1 mice.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Energy Metabolism; Haloperidol; Insulin-Secreting Cells; Male; Mice; Mitochondria | 2021 |
Characterization hiPSC-derived neural progenitor cells and neurons to investigate the role of NOS1AP isoforms in human neuron dendritogenesis.
Topics: Adaptor Proteins, Signal Transducing; Cells, Cultured; Clozapine; Dendrites; Drug Evaluation, Preclinical; Fluphenazine; Gene Expression Regulation; Glutamic Acid; Haloperidol; Humans; Induced Pluripotent Stem Cells; Ion Channels; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Oligopeptides; Patch-Clamp Techniques; Protein Isoforms; Schizophrenia; Serine | 2020 |
Evaluation of NDEL1 oligopeptidase activity in blood and brain in an animal model of schizophrenia: effects of psychostimulants and antipsychotics.
Topics: Animals; Antipsychotic Agents; Brain; Central Nervous System Stimulants; Clozapine; Cysteine Endopeptidases; Haloperidol; Hippocampus; Male; Nucleus Accumbens; Prefrontal Cortex; Psychotic Disorders; Rats; Rats, Inbred SHR; Rats, Wistar; Schizophrenia | 2020 |
Exploring a Safety Signal of Antipsychotic-Associated Pneumonia: A Pharmacovigilance-Pharmacodynamic Study.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Antipsychotic Agents; Clozapine; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Female; Haloperidol; Humans; Male; Middle Aged; Olanzapine; Pharmacovigilance; Pneumonia; Pneumonia, Aspiration; Receptors, Muscarinic; United States; United States Food and Drug Administration; Young Adult | 2021 |
Risk and Prevention of Aggression in Patients With Psychotic Disorders.
Topics: Aggression; Clozapine; Conduct Disorder; Haloperidol; Humans; Olanzapine; Psychotic Disorders; Schizophrenia; Violence | 2021 |
Proteome Analysis of PC12 Cells Reveals Alterations in Translation Regulation and Actin Signaling Induced by Clozapine.
Topics: Actin Cytoskeleton; Acute-Phase Reaction; Animals; Antipsychotic Agents; Ciliary Neurotrophic Factor; Clozapine; Haloperidol; PC12 Cells; Protein Biosynthesis; Proteome; Rats; rho GTP-Binding Proteins; Risperidone; Signal Transduction | 2021 |
Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis.
Topics: Animals; Antipsychotic Agents; Autophagy; Autophagy-Related Proteins; Axons; Biomarkers; Clozapine; Cytokines; Demyelinating Diseases; Disease Models, Animal; Glucose; Haloperidol; Inflammation; Interleukin-1beta; Mitochondria; Mitophagy; Models, Biological; Motor Activity; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Stress, Physiological; Tumor Necrosis Factor-alpha | 2021 |
The type rather than the daily dose or number of antipsychotics affects the incidence of hyperglycemic progression.
Topics: Adult; Antipsychotic Agents; Clozapine; Dibenzothiepins; Female; Haloperidol; Humans; Hyperglycemia; Incidence; Japan; Male; Middle Aged; Piperazines; Piperidines; Prospective Studies; Schizophrenia | 2022 |
Atypical, but Not Typical, Antipsychotic Drugs Reduce Hypersynchronized Prefrontal-Hippocampal Circuits during Psychosis-Like States in Mice: Contribution of 5-HT2A and 5-HT1A Receptors.
Topics: Animals; Antipsychotic Agents; Clozapine; Haloperidol; Hippocampus; Mice; Phencyclidine; Prefrontal Cortex; Psychotic Disorders; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Risperidone; Serotonin Antagonists | 2022 |
Sex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome.
Topics: Animals; Antipsychotic Agents; Clozapine; Erythrocytes; Female; Haloperidol; Humans; Iron; Liver; Male; Metabolic Syndrome; Rats; Rats, Sprague-Dawley | 2022 |
Influence of haloperidol and clozapine on the cognitive performance in patients with psychotic disorders: possible attributes.
Topics: Antipsychotic Agents; Clozapine; Cognition; Haloperidol; Humans; Psychotic Disorders | 2023 |
Do antipsychotic drugs shrink the brain? Probably not.
Topics: Antipsychotic Agents; Brain; Clozapine; Haloperidol | 2022 |
Characteristics of adverse reactions among antipsychotic drugs using the Korean Adverse Event Reporting System database from 2010 to 2019.
Topics: Adolescent; Adult; Aged; Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Child; Clozapine; Drug-Related Side Effects and Adverse Reactions; Haloperidol; Humans; Olanzapine; Paliperidone Palmitate; Quetiapine Fumarate; Retrospective Studies; Risperidone; Schizophrenia | 2022 |
Letter to the Editor: Rethinking The Cost Of Antipsychotic Treatment: The Average Cost Of The Drugs Used In Turkey In 2020.
Topics: Adenosine Monophosphate; Adult; Amisulpride; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Chlorpromazine; Clopenthixol; Clozapine; Flupenthixol; Fluphenazine; Haloperidol; Humans; Olanzapine; Paliperidone Palmitate; Pharmaceutical Preparations; Pimozide; Quetiapine Fumarate; Risperidone; Sulpiride; Trifluoperazine | 2022 |
Environmentally-relevant concentrations of the antipsychotic drugs sulpiride and clozapine induce abnormal dopamine and serotonin signaling in zebrafish brain.
Topics: Animals; Antipsychotic Agents; Brain; Clozapine; Dopamine; Haloperidol; Monoamine Oxidase; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sulpiride; Zebrafish | 2022 |
Differential Effects of Clozapine and Haloperidol on the 40 Hz Auditory Steady State Response-mediated Phase Resetting in the Prefrontal Cortex of the Female Sprague Dawley Rat.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Clozapine; Electroencephalography; Evoked Potentials, Auditory; Female; Haloperidol; Prefrontal Cortex; Rats; Rats, Sprague-Dawley | 2023 |
Evaluation of Antipsychotic Drugs' Stability in Oral Fluid Samples.
Topics: Antipsychotic Agents; Chlorpromazine; Clozapine; Gas Chromatography-Mass Spectrometry; Haloperidol; Methotrimeprazine; Quetiapine Fumarate | 2023 |
Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum?
Topics: Antipsychotic Agents; Clozapine; Corpus Striatum; Glutamic Acid; Haloperidol | 2023 |
Lu AF35700 reverses the phencyclidine-induced disruption of thalamo-cortical activity by blocking dopamine D
Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Dopamine Antagonists; Haloperidol; Phencyclidine; Rats; Receptors, Dopamine D1 | 2023 |
Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia.
Topics: Animals; Clozapine; Cognitive Dysfunction; Haloperidol; Male; Methamphetamine; Mice; Monomeric GTP-Binding Proteins; Protein Kinase Inhibitors; rho-Associated Kinases; Schizophrenia | 2023 |