haloperidol has been researched along with 8-hydroxy-2-(di-n-propylamino)tetralin in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (9.45) | 18.7374 |
| 1990's | 52 (40.94) | 18.2507 |
| 2000's | 48 (37.80) | 29.6817 |
| 2010's | 13 (10.24) | 24.3611 |
| 2020's | 2 (1.57) | 2.80 |
| Authors | Studies |
|---|---|
| Baldy, WJ; Davis, CB; DiStefano, DL; Elgin, RJ; Fedde, CL; Kesslick, JM; Martin, GE; Mathiasen, JR; Scott, MK; Shank, RP | 1 |
| Berardi, F; Colabufo, NA; Fiorentini, F; Ghiglieri, A; Govoni, S; Leopoldo, M; Olgiati, V; Perrone, R; Tortorella, V | 1 |
| Chidester, CG; Haadsma-Svensson, SR; Lahti, RA; Lin, CH; McCall, RB; Piercey, MF; Schreur, PJ; Smith, MW; Von Voigtlander, PF | 1 |
| Chidester, CG; Haadsma-Svensson, SR; Lahti, RA; Lin, CH; McCall, RB; Phillips, G; Piercey, MF; Schreur, PJ; Smith, MW; Von Voigtlander, PF | 1 |
| Foulon, C; Kung, HF; Kung, MP | 1 |
| Amlaiky, N; Hen, R; Plassat, JL | 1 |
| Arrang, JM; Diaz, J; Leurs, R; Ruat, M; Schwartz, JC; Tardivel-Lacombe, J; Traiffort, E | 1 |
| Berardi, F; Colabufo, NA; Giudice, G; Govoni, S; Lucchi, L; Perrone, R; Tortorella, V | 1 |
| Berardi, F; Caccia, C; Fornaretto, MG; Leopoldo, M; McArthur, RA; Perrone, R; Tortorella, V | 1 |
| Berardi, F; Giudice, G; Govoni, S; Lucchi, L; Perrone, R; Tortorella, V | 1 |
| Berardi, F; Caccia, C; Colabufo, NA; Fornaretto, MG; Leopoldo, M; McArthur, RA; Perrone, R; Tortorella, V | 1 |
| Labeaga, L; Mosquera, R; Orjales, A; Rodes, R | 1 |
| Audinot, V; Lejeune, F; Millan, MJ; Newman-Tancredi, A | 1 |
| Dokhan, R; el Ahmad, Y; Laurent, E; Maillet, P; Ollivier, R; Talab, A; Teste, JF; Tran, G | 1 |
| Chang, DJ; Eglen, RM; Jasper, JR; Kosaka, A; To, ZP | 1 |
| Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L | 1 |
| Fujio, M; Katayama, J; Kuroita, T; Matsumoto, Y; Morio, Y; Togo, Y; Tomozane, H | 1 |
| Berardi, F; Colabufo, NA; Lacivita, E; Leonardi, A; Leopoldo, M; Perrone, R; Poggesi, E; Testa, R; Tortorella, V | 1 |
| Berardi, F; Colabufo, NA; De Giorgio, P; Lacivita, E; Leopoldo, M; Perrone, R; Tortorella, V | 1 |
| Glennon, RA | 1 |
| Bourdiol, N; Colpaert, F; Cuisiat, S; Lacharme, V; Newman-Tancredi, A; Vacher, B | 1 |
| Berardi, F; Colabufo, NA; Contino, M; Lacivita, E; Leopoldo, M; Perrone, R | 1 |
| Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L | 1 |
| Berardi, F; Caccia, S; Colabufo, NA; Contino, M; De Giorgio, P; Fracasso, C; Guzzetti, S; Lacivita, E; Leopoldo, M; Perrone, R | 1 |
| Altenbach, RJ; Brioni, JD; Carr, TL; Chandran, P; Cowart, MD; Esbenshade, TA; Honore, P; Hsieh, GC; Lewis, LG; Liu, H; Manelli, AM; Marsh, KC; Milicic, I; Miller, TR; Strakhova, MI; Vortherms, TA; Wakefield, BD; Wetter, JM; Witte, DG | 1 |
| Balsamo, A; Berardi, F; Colabufo, NA; Digiacomo, M; Perrone, R; Rapposelli, S; Vanni, M | 1 |
| Anzini, M; Brogi, S; Butini, S; Campiani, G; Cappelli, A; Caselli, G; Castriconi, F; Gemma, S; Giordani, A; Giorgi, G; Giuliani, G; Lanza, M; Letari, O; Makovec, F; Manini, M; Mennuni, L; Valenti, S | 1 |
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Bienkowski, P; Bucki, A; Jaśkowska, J; Kazek, G; Kowalski, P; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Mitka, K; Pawłowski, M; Siwek, A; Wasik, A; Wesołowska, A | 1 |
| Bienkowski, P; Bucki, A; Jastrzębska-Więsek, M; Kazek, G; Kołaczkowski, M; Marcinkowska, M; Mierzejewski, P; Partyka, A; Pawłowski, M; Siwek, A; Śniecikowska, J; Wasik, A; Wesołowska, A | 1 |
| Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E | 1 |
| Filipek, B; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pańczyk, K; Pękala, E; Rapacz, A; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E | 1 |
| Bączek, T; Belka, M; Bojarski, A; Herold, F; Kleps, J; Kozioł, AE; Król, M; Nowak, G; Siwek, A; Ślifirski, G; Stachowicz, K; Szewczyk, B; Turło, J; Ulenberg, S | 1 |
| Alberts, I; Harding, WW; Juarez, R; Karki, A; Namballa, HK | 1 |
| Alberts, I; Harding, WW; Karki, A; Namballa, HK | 1 |
| Flores, CM; Hornby, PJ; Hulihan-Giblin, BA; Kellar, KJ; Lumpkin, MD | 1 |
| Rigdon, GC; Weatherspoon, JK | 1 |
| Ewing, FE; Furman, JS; Heym, JH; Howard, HR; Lowe, JA; Nagel, AA; Newman, ME; Schmidt, AW; Seeger, TF; Seymour, PA | 1 |
| Fletcher, PJ | 2 |
| Davies, M; Fletcher, PJ | 2 |
| Backus, LI; Grahame-Smith, DG; Sharp, T | 1 |
| Kalkman, HO; Soar, J | 1 |
| Lum, JT; Piercey, MF | 1 |
| Gerber, R; Gerhardt, SC; Liebman, JM | 1 |
| Meltzer, HY; Nash, JF | 1 |
| Gudelsky, GA; Meltzer, HY; Nash, JF | 1 |
| Ahlenius, S; Fernández-Guasti, A; Hjorth, S; Larsson, K | 1 |
| Lambert, G; Monroe, PJ; Nelson, DL; Yamamura, HI | 1 |
| Cervo, L; Samanin, R | 1 |
| Cervo, L; Invernizzi, RW; Samanin, R | 1 |
| Berendsen, HH; Broekkamp, CL; Oosterloo, SK; van Delft, AM | 1 |
| Arbogast, R; Palfreyman, MG; Wagner, J; Zreika, M | 1 |
| Ahlenius, S; Larsson, K | 1 |
| Czyrak, A; Frankiewicz, T; Maj, J; Rogóz, Z; Skuza, G | 1 |
| Conway, PC; Corbett, R; Dunn, RW; Hartman, H; Helsley, GC; Kerman, LL; Strupczewski, JT; Woods, AT | 1 |
| Caine, SB; Geyer, MA; Swerdlow, NR | 1 |
| Ikeda, K; Ishibashi, T; Ishida, K; Kato, T; Nakamura, M; Ohno, Y | 1 |
| Kling-Petersen, T; Ljung, E; Svensson, K | 1 |
| Cools, AR; Ellenbroek, BA; Prinssen, EP | 1 |
| Fornal, CA; Jacobs, BL; Litto, WJ; Marrosu, F; Metzler, CW; Tada, K | 1 |
| Lum-Ragan, JT; Piercey, MF; Smith, MW | 1 |
| Carlsson, A; Lagerkvist, S; Löfberg, L; Piercey, M; Waters, N | 1 |
| Chaput, C; Millan, MJ; Newman-Tancredi, A; Verriele, L | 1 |
| Andersen, HL; Kilpatrick, IC | 1 |
| Burnet, PW; Chen, CP; Franklin, M; Harrison, PJ; McGowan, S | 1 |
| Burnet, PW; Eastwood, SL; Harrison, PJ | 1 |
| Kleven, MS; Koek, W; Prinssen, EP | 1 |
| Bartoszyk, GD; Roos, C; Ziegler, H | 1 |
| Kleven, MS; Koek, W | 1 |
| Ichikawa, J; Meltzer, HY; Sumiyoshi, T | 1 |
| Fdez Espejo, E; Gil, E | 1 |
| Bonhomme, N; De Deurwaerdère, P; Le Moal, M; Lucas, G; Spampinato, U | 1 |
| Nakajima, S; Patterson, RL | 1 |
| Hoffmann, WE; Hyslop, DK; Piercey, MF | 1 |
| Christoffersen, CL; Meltzer, LT | 1 |
| Gervais, J; Rouillard, C; Tremblay, PO | 1 |
| Ishikane, T | 1 |
| Christ, G; Kaynan, A; Maayani, S; Melman, A; Rehman, J; Valcic, M | 1 |
| Evenden, J; Meyerson, B | 1 |
| Annoh, N; Harano, M; Tanaka, M; Yamada, S | 1 |
| Gainetdinov, R; Huotari, M; Männistö, PT | 1 |
| Ichikawa, J; Meltzer, HY | 1 |
| Caccia, S; De Deurwaerdère, P; Lucas, G | 1 |
| Ferger, B; Teismann, P | 1 |
| Hillefors, M; von Euler, G | 1 |
| Carey, R; Damianopoulos, E; De Palma, G | 1 |
| Colpaert, FC; Kleven, MS; Koek, W; Prinssen, EP | 1 |
| Costall, B; Neill, JC; Wilson, AW | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Gainetdinov, RR; Grekhova, TV; Rayevsky, KS; Sotnikova, TD | 1 |
| Kurasawa, M; Nakamura, K | 1 |
| Andorn, AC; Pappolla, MA | 1 |
| Colpaert, FC; Pauwels, PJ; Tardif, S; Wurch, T | 1 |
| Cervo, L; De Deurwaerdère, P; Spampinato, U; Stinus, L | 1 |
| Dai, J; Ichikawa, J; Meltzer, HY | 1 |
| Bijak, M; Tokarski, K; Zahorodna, A | 1 |
| Carbone, KM; Moran, TH; Pletnikov, MV; Rubin, SA; Vogel, MW | 1 |
| Haleem, DJ; Khan, NH | 1 |
| Morales, M; Oz, M; Rotondo, A; Sun, H; Zhang, L | 1 |
| Billinton, A; Duxon, MS; Quinn, LP; Stean, TO; Stratton, SC; Trail, B; Upton, N | 1 |
| Bartoszyk, GD; Lorenc-Koci, E; Wardas, J; Wolfarth, S | 1 |
| Baker, LE; Meltzer, HY; Prus, AJ | 1 |
| Matsuoka, N; Mutoh, S; Shirakawa, K; Tada, M | 1 |
| Haleem, DJ; Haleem, MA; Shireen, E | 1 |
| Hou, Y; Huang, M; Wu, CF; Yang, JY | 1 |
| Bruins Slot, LA; Kleven, MS; Newman-Tancredi, A | 1 |
| Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R | 1 |
| Bermack, JE; Debonnel, G | 1 |
| Assié, MB; Carilla-Durand, E; Cosi, C; Leduc, N; Maraval, M; Newman-Tancredi, A; Ormiere, AM | 1 |
| Haleem, DJ; Haleem, MA; Samad, N | 2 |
| Gajendiran, M | 1 |
| Abdul Haleem, M; Haider, S; Haleem, DJ; Khan, A; Perveen, T; Samad, N | 1 |
| Imaki, J; Ishihara, S; Kawai, Y; Ohno, Y; Sasa, M; Shimizu, S; Sofue, N | 2 |
| Bogeski, M; Gogos, A; van den Buuse, M | 1 |
| Dhir, A; Kulkarni, SK | 1 |
| Batool, F; Haleem, DJ | 1 |
| Auclair, AL; Barret-Grévoz, C; Barreto, M; Depoortère, R; Kleven, MS; Newman-Tancredi, A | 1 |
| Bruins Slot, LA; Cussac, D; Grevoz-Barret, C; Lestienne, F; Newman-Tancredi, A | 1 |
| Hanania, T; Paterson, NE | 1 |
| Akagawa, K; Fujiwara, T; Kofuji, T; Snada, M; Yoshikawa, T | 1 |
| Haleem, DJ; Samad, N; Yasmin, F | 1 |
| Ahmadi, SA; Haddadi, R; Sabahi, M | 1 |
| Alemany-González, M; Chanovas, J; Delgado-Sallent, C; Gener, T; Nebot, P; Puig, MV; Tauste Campo, A | 1 |
1 review(s) available for haloperidol and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Topics: Animals; Humans; Ligands; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
126 other study(ies) available for haloperidol and 8-hydroxy-2-(di-n-propylamino)tetralin
| Article | Year |
|---|---|
Activity of aromatic substituted phenylpiperazines lacking affinity for dopamine binding sites in a preclinical test of antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Dose-Response Relationship, Drug; Piperazines; Rats; Receptors, Dopamine; Receptors, Serotonin; Structure-Activity Relationship | 1989 |
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[1-tetralin)alkyl]piperazines. 2.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Guinea Pigs; Isomerism; Kinetics; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Structure-Activity Relationship; Tetrahydronaphthalenes | 1995 |
Centrally acting serotonergic and dopaminergic agents. 1. Synthesis and structure-activity relationships of 2,3,3a,4,5,9b-hexahydro-1H-benz[e]indole derivatives.
Topics: Animals; Brain; Cats; Cattle; Dopamine Agents; Indoles; Male; Mice; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship | 1993 |
Centrally acting serotonergic and dopaminergic agents. 2. Synthesis and structure-activity relationships of 2,3,3a,4,9,9a-hexahydro-1H-benz[f]indole derivatives.
Topics: Animals; Binding Sites; Brain; Cats; Cattle; Dopamine Agents; Indoles; Male; Mice; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes | 1993 |
Synthesis of (R,S)-2'-trans-7-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'- propenyl)-amino]tetralin (trans-7-OH-PIPAT): a new D3 dopamine receptor ligand.
Topics: Binding Sites; Dopamine Agents; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Salicylamides; Stereoisomerism; Tetrahydronaphthalenes | 1993 |
Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cloning, Molecular; Cyclic AMP; DNA; Drosophila; Enzyme Activation; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Myocardium; Receptors, Serotonin; Sequence Homology, Amino Acid; Serotonin Antagonists; Serotonin Receptor Agonists | 1993 |
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; CHO Cells; Cricetinae; Cyclic AMP; DNA; Genomic Library; Kinetics; Lysergic Acid Diethylamide; Mianserin; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, Serotonin; Restriction Mapping; Serotonin; Serotonin Receptor Agonists; Transfection | 1993 |
New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.
Topics: Analgesics, Opioid; Animals; Binding Sites; Brain; Guinea Pigs; Magnetic Resonance Spectroscopy; Male; Pentazocine; Phencyclidine; Piperazines; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Phencyclidine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, sigma; Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
1-aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3.
Topics: Animals; Buspirone; Mass Spectrometry; Molecular Structure; Piperazines; Protein Binding; Rats; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists | 1996 |
Novel potent sigma 1 ligands: N-[omega-(tetralin-1-yl)alkyl]piperidine derivatives.
Topics: Animals; Hippocampus; Ketanserin; Phencyclidine; Piperidines; Rats; Receptors, Phencyclidine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, sigma; Spiperone; Structure-Activity Relationship; Tetrahydronaphthalenes | 1996 |
Structure-activity relationship studies on the 5-HT(1A) receptor affinity of 1-phenyl-4-[omega-(alpha- or beta-tetralinyl)alkyl]piperazines. 4.
Topics: Magnetic Resonance Spectroscopy; Piperazines; Radioligand Assay; Receptors, Serotonin; Structure-Activity Relationship | 1996 |
New 2-piperazinylbenzimidazole derivatives as 5-HT3 antagonists. Synthesis and pharmacological evaluation.
Topics: Animals; Benzimidazoles; Guinea Pigs; Indazoles; Male; Models, Chemical; Piperazines; Piperidines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Tropanes | 1997 |
Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine Agonists; Dopamine Antagonists; Humans; Male; Neurons; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, Serotonin; Recombinant Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Tetrahydronaphthalenes | 1997 |
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Topics: Adenylyl Cyclases; Animals; Behavior, Animal; Binding, Competitive; Colforsin; Cyclic AMP; Electrophysiology; Enzyme Activation; Kinetics; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Piperazines; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship | 1997 |
Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Cyclic AMP; DNA, Complementary; Humans; Molecular Sequence Data; Placenta; Radioligand Assay; Rats; Receptors, Serotonin; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid | 1997 |
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes | 1998 |
N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarboxamides as selective 5-HT1A receptor agonists.
Topics: Amides; Animals; Binding, Competitive; In Vitro Techniques; Neurons; Pyrrolidines; Raphe Nuclei; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 2000 |
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.
Topics: Animals; Brain; Ethylamines; Guanosine 5'-O-(3-Thiotriphosphate); HeLa Cells; Humans; In Vitro Techniques; Ligands; Molecular Conformation; Piperazines; Pyridines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stereoisomerism; Structure-Activity Relationship; Transfection | 2001 |
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.
Topics: Animals; Benzamides; Benzofurans; Cell Line; Cerebral Cortex; Hippocampus; Humans; In Vitro Techniques; Ligands; Piperazines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Structure-Activity Relationship | 2002 |
Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Benzylamines; Dopamine D2 Receptor Antagonists; HeLa Cells; Humans; Radioligand Assay; Rats; Serotonin 5-HT1 Receptor Agonists; Signal Transduction; Stereoisomerism; Structure-Activity Relationship | 2007 |
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
Topics: Amides; Animals; Cell Line; Guinea Pigs; Humans; Ileum; Male; Muscle Contraction; Muscle, Smooth; Piperazines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Structure-Activity Relationship; Tetrahydronaphthalenes | 2007 |
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2008 |
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.
Topics: Animals; Blood-Brain Barrier; Brain; Mice; Molecular Structure; Piperazines; Receptors, Serotonin | 2008 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Ligands; Mice; Molecular Structure; Pain; Peritonitis; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Stereoisomerism; Structure-Activity Relationship | 2008 |
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Drug Design; Fluoresceins; Humans; Molecular Structure; Phenyl Ethers; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2008 |
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Topics: Animals; Area Under Curve; Humans; Intestinal Absorption; Ligands; Male; Metabolic Clearance Rate; Models, Chemical; Models, Molecular; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Pyrrolidinones; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT3; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship | 2013 |
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Avoidance Learning; Benzoxazoles; Catalepsy; CHO Cells; Cricetulus; Dementia; Dopamine D2 Receptor Antagonists; HEK293 Cells; Humans; Male; Models, Molecular; Motor Activity; Radioligand Assay; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Sulfonamides | 2014 |
Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
Topics: Animals; Benzamides; Dementia; Dose-Response Relationship, Drug; Drug Partial Agonism; Humans; Indoles; Ligands; Male; Models, Molecular; Molecular Structure; Piperazines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin; Structure-Activity Relationship; Swimming | 2015 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Drug Design; Epilepsy; Male; Mice; Microsomes, Liver; Molecular Structure; Pilocarpine | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Mice; Models, Molecular; Molecular Structure; Rats; Seizures; Structure-Activity Relationship | 2017 |
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT
Topics: Animals; Chemistry Techniques, Synthetic; Drug Design; Ligands; Mice; Pyrimidines; Receptor, Serotonin, 5-HT1A; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Tryptamines | 2019 |
Identification of C10 nitrogen-containing aporphines with dopamine D
Topics: Aporphines; Dopamine Agonists; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Receptors, Dopamine D1; Receptors, Dopamine D5; Structure-Activity Relationship | 2020 |
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT
Topics: Aporphines; Cell Line; Humans; Ligands; Molecular Docking Simulation; Molecular Structure; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 2020 |
Partial characterization of a neurotransmitter pathway regulating the in vivo release of prolactin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bromocriptine; Haloperidol; Male; Mecamylamine; Methysergide; Morphine; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nicotine; Nicotinic Antagonists; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Nicotinic; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1992 |
5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Buspirone; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Methoxydimethyltryptamines; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Serotonin Receptor Agonists | 1992 |
1-Naphthylpiperazine derivatives as potential atypical antipsychotic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Apomorphine; Autoradiography; Behavior, Animal; Dopamine Antagonists; Haloperidol; Ketanserin; Locomotion; Male; Piperazines; Prazosin; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tetrahydronaphthalenes | 1991 |
Dopamine receptor blockade in nucleus accumbens or caudate nucleus differentially affects feeding induced by 8-OH-DPAT injected into dorsal or median raphe.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Caudate Nucleus; Dose-Response Relationship, Drug; Feeding Behavior; Flupenthixol; Haloperidol; Male; Nucleus Accumbens; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin Antagonists; Stereotaxic Techniques; Tetrahydronaphthalenes | 1991 |
A pharmacological analysis of the eating response induced by 8-OH-DPAT injected into the dorsal raphé nucleus reveals the involvement of a dopaminergic mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Drug Interactions; Eating; Haloperidol; Injections; Male; Metergoline; Naphthalenes; Propranolol; Raphe Nuclei; Rats; Rats, Inbred Strains; Spiperone; Tetrahydronaphthalenes | 1990 |
The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dopamine; Dose-Response Relationship, Drug; Eating; Fenclonine; Haloperidol; Male; Pyrimidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Tetrahydronaphthalenes | 1990 |
Behavioural evidence for a functional interaction between central 5-HT2 and 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Haloperidol; Ketanserin; Male; Methoxydimethyltryptamines; Piperidines; Prazosin; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Ritanserin; Serotonin; Stereotyped Behavior; Tetrahydronaphthalenes | 1990 |
Determination of the 5-HT receptor subtype involved in 8-OH-DPAT-induced hyperlocomotion: potential difficulties arising from inadequate pharmacological tools.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dioxanes; Haloperidol; Male; Motor Activity; Pindolol; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Spiro Compounds; Tetrahydronaphthalenes | 1990 |
Electrophysiological effects of dopamine autoreceptor antagonists, (+)-AJ 76 and (+)-UH 232.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamine; Animals; Apomorphine; Dendrites; Dopamine; Dopamine Antagonists; Electrophysiology; Feedback; Haloperidol; In Vitro Techniques; Male; Naphthalenes; Neurons; Rats; Rats, Inbred Strains; Substantia Nigra; Tetrahydronaphthalenes | 1990 |
Effects of 5-HT1A agonists and 5-HT2 antagonists on haloperidol-induced dyskinesias in squirrel monkeys: no evidence for reciprocal 5-HT-dopamine interaction.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Avoidance Learning; Buspirone; Dopamine; Haloperidol; Male; Movement Disorders; Pyrimidinones; Saimiri; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1989 |
Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Electric Stimulation; Haloperidol; Male; Methoxydimethyltryptamines; Methyltyrosines; Prolactin; Pyrazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tetrahydronaphthalenes | 1989 |
Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Body Temperature; Butyrophenones; Chlorpromazine; Clozapine; Corticosterone; Haloperidol; Male; Neurosecretory Systems; Pyrazines; Pyrimidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes | 1988 |
8-OH-DPAT elicits gnawing, and eating of solid but not liquid foods.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drinking; Eating; Glucose; Haloperidol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Stereotyped Behavior; Tetrahydronaphthalenes | 1987 |
Separation of dopaminergic and serotonergic inhibitory mechanisms in the mediation of estrogen-induced lordosis behaviour in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Dopamine; Ergolines; Estradiol; Female; Haloperidol; Lisuride; Male; Ovariectomy; Posture; Quinpirole; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Sexual Behavior, Animal; Tetrahydronaphthalenes | 1987 |
[3H]spiroxatrine labels a serotonin1A-like site in the rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Cell Membrane; Dioxanes; Dioxins; Dopamine; Guanosine Triphosphate; Haloperidol; Hippocampus; Male; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Spiperone; Spiro Compounds; Tetrahydronaphthalenes; Tritium | 1987 |
Potential antidepressant properties of 8-hydroxy-2-(di-n-propylamino)tetralin, a selective serotonin1A receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Interactions; Haloperidol; Male; Methiothepin; Naphthalenes; Physical Exertion; Rats; Receptors, Serotonin; Serotonin; Sulpiride; Swimming; Tetrahydronaphthalenes | 1987 |
8-Hydroxy-2-(di-n-propylamino) tetralin, a selective serotonin1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Catalepsy; Haloperidol; Male; Naphthalenes; Raphe Nuclei; Rats; Receptors, Serotonin; Tetrahydronaphthalenes | 1988 |
Effect of metergoline, fenfluramine, and 8-OHDPAT on catalepsy induced by haloperidol or morphine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Catalepsy; Drug Interactions; Fenfluramine; Haloperidol; Male; Metergoline; Mice; Morphine; Rats; Rats, Inbred Strains; Serotonin; Tetrahydronaphthalenes | 1988 |
A method for measuring monoamine turnover in animals using an irreversible inhibitor of aromatic L-amino acid decarboxylase, DL-alpha-mono fluoromethyldopa.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Biogenic Amines; Brain Chemistry; Dopamine; Haloperidol; Hydroxyindoleacetic Acid; Male; Methyldopa; Mice; Norepinephrine; Rats; Rats, Inbred Strains; Serotonin; Species Specificity; Tetrahydronaphthalenes; Time Factors | 1984 |
Lisuride, LY-141865, and 8-OH-DPAT facilitate male rat sexual behavior via a non-dopaminergic mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Ergolines; Haloperidol; Lisuride; Male; Naphthalenes; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal; Tetrahydronaphthalenes | 1984 |
Pharmacological action of zotepine and other antipsychotics on central 5-hydroxytryptamine receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Body Temperature; Clozapine; Dibenzothiepins; Exploratory Behavior; Haloperidol; Isoxazoles; Male; Mice; Motor Activity; Piperazines; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Effects of atypical antipsychotic agents on social behavior in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Catalepsy; Chlorpromazine; Clozapine; Diazepam; Haloperidol; Isoxazoles; Male; Mice; Mice, Inbred Strains; Piperidines; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Salicylamides; Social Behavior | 1993 |
Effects of D3/D2 dopamine receptor agonists and antagonists on prepulse inhibition of acoustic startle in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Apomorphine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Humans; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Reflex, Startle; Schizophrenia; Tetrahydronaphthalenes | 1995 |
Effects of chronic treatments with SM-9018, a potential atypical neuroleptic, on behavioral dopaminergic and serotonergic sensitivities in rats.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Dopamine; Haloperidol; Indoles; Isoindoles; Male; Motor Activity; Posture; Rats; Rats, Sprague-Dawley; Serotonin; Stereotyped Behavior; Thiazoles | 1995 |
The preferential dopamine autoreceptor antagonist (+)-UH232 antagonizes the positive reinforcing effects of cocaine and d-amphetamine in the ICSS paradigm.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Cocaine; Dextroamphetamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrodes; Haloperidol; Male; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Stimulation | 1994 |
The role of serotonin receptor subtypes in the behavioural effects of neuroleptic drugs. A paw test study in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Behavior, Animal; Clozapine; Haloperidol; Ketanserin; Male; Rats; Rats, Wistar; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists | 1994 |
Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cats; Depression, Chemical; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Male; Membrane Potentials; Neurons; Premedication; Raphe Nuclei; Ritanserin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone | 1994 |
Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dopamine; Dopamine Antagonists; Haloperidol; Locus Coeruleus; Male; Neurons; Norepinephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Substantia Nigra | 1994 |
The dopamine D3 receptor and autoreceptor preferring antagonists (+)-AJ76 and (+)-UH232; a microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Corpus Striatum; Dopamine; Dopamine Antagonists; Haloperidol; Male; Microdialysis; Neurons; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Salicylamides; Substantia Nigra; Tetrahydronaphthalenes; Ventral Tegmental Area | 1993 |
Clozapine is a partial agonist at cloned, human serotonin 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; CHO Cells; Clozapine; Cricetinae; Dose-Response Relationship, Drug; Haloperidol; Humans; Kinetics; Receptors, Serotonin | 1996 |
Prevention by (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin of both catalepsy and the rises in rat striatal dopamine metabolism caused by haloperidol.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Catalepsy; Corpus Striatum; Dopamine; Dopamine Antagonists; Haloperidol; Homovanillic Acid; Male; Rats; Serotonin Receptor Agonists | 1996 |
The effects of clozapine and haloperidol on serotonin-1A, -2A and -2C receptor gene expression and serotonin metabolism in the rat forebrain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Cerebral Cortex; Clozapine; Corpus Striatum; Haloperidol; Hippocampus; Hydroxyindoleacetic Acid; In Situ Hybridization; Ketanserin; Male; Organ Specificity; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reference Values; RNA, Messenger; Serotonin; Transcription, Genetic; Tritium | 1996 |
5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Animals; Antipsychotic Agents; Autoradiography; Binding Sites; Brain; Female; Haloperidol; Humans; Ketanserin; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Schizophrenia | 1996 |
Effects of dopamine antagonists in a two-way active avoidance procedure in rats: interactions with 8-OH-DPAT, ritanserin, and prazosin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Avoidance Learning; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Prazosin; Raclopride; Rats; Rats, Sprague-Dawley; Ritanserin; Salicylamides; Serotonin Agents | 1996 |
5-HT1A receptors are not involved in clozapine's lack of cataleptogenic potential.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Catalepsy; Clozapine; Haloperidol; Male; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Ultrasonics; Vocalization, Animal | 1996 |
Dopamine D2 receptors play a role in the (-)-apomorphine-like discriminative stimulus effects of (+)-PD 128907.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Benzopyrans; Conditioning, Operant; Discrimination, Psychological; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Male; Oxazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 1997 |
The effect of streptozotocin-induced diabetes on dopamine2, serotonin1A and serotonin2A receptors in the rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Diabetes Mellitus, Experimental; Dopamine Antagonists; Frontal Lobe; Haloperidol; Hippocampus; Ketanserin; Male; Neostriatum; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Streptozocin | 1997 |
Single restraint stress sensitizes acute chewing movements induced by haloperidol, but not if the 5-HT1A agonist 8-OH-DPAT is given prior to stress.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Catalepsy; Dopamine Antagonists; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; Haloperidol; Male; Rats; Rats, Wistar; Restraint, Physical; Serotonin Receptor Agonists; Stress, Physiological | 1997 |
8-OH-DPAT, a 5-HT1A agonist and ritanserin, a 5-HT2A/C antagonist, reverse haloperidol-induced catalepsy in rats independently of striatal dopamine release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Catalepsy; Dopamine; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Ritanserin; Visual Cortex | 1997 |
The involvement of dopamine D2 receptors, but not D3 or D4 receptors, in the rewarding effect of brain stimulation in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Nucleus Accumbens; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Reward; Salicylamides; Self Stimulation | 1997 |
Excitation of type II anterior caudate neurons by stimulation of dopamine D3 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminoquinolines; Animals; Benzothiazoles; Caudate Nucleus; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Imidazoles; Neurons; Pramipexole; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Tetrahydronaphthalenes; Thiazoles | 1997 |
Reversal of haloperidol-induced extrapyramidal side effects in cebus monkeys by 8-hydroxy-2-(di-n-propylamino)tetralin and its enantiomers.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Dyskinesia Agents; Antipsychotic Agents; Apomorphine; Basal Ganglia Diseases; Cebus; Female; Haloperidol; Male; Serotonin Receptor Agonists; Stereoisomerism; Time Factors | 1998 |
Modification of haloperidol-induced pattern of c-fos expression by serotonin agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Clozapine; Haloperidol; Male; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists | 1998 |
[Effects of serotonergic drugs on the up-regulation of dopamine D2 receptors induced by haloperidol in rat striatum].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Dyskinesia Agents; Antipsychotic Agents; Citalopram; Corpus Striatum; Dopamine Antagonists; Haloperidol; Male; Pyrazines; Rats; Rats, Wistar; Receptors, Dopamine D2; Ritanserin; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Up-Regulation | 1998 |
Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Buspirone; Copulation; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Penile Erection; Penis; Piperazines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, Dopamine D2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Serotonin; Serotonin Receptor Agonists; Spiperone | 1999 |
The behavior of spontaneously hypertensive and Wistar Kyoto rats under a paced fixed consecutive number schedule of reinforcement.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Chlordiazepoxide; Conditioning, Operant; Dextroamphetamine; Haloperidol; Hypertension; Imipramine; Piperazines; Psychotropic Drugs; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reinforcement Schedule; Species Specificity | 1999 |
Dopamine D(3) receptors modulate evoked dopamine release from slices of rat nucleus accumbens via muscarinic receptors, but not from the striatum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dopamine; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; Haloperidol; In Vitro Techniques; Indans; Male; Muscarinic Antagonists; Neostriatum; Nucleus Accumbens; Pirenzepine; Quinpirole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Muscarinic | 1999 |
Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzophenones; Carbidopa; Catechol O-Methyltransferase; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Interactions; Enzyme Inhibitors; Extracellular Space; Haloperidol; Homovanillic Acid; Levodopa; Male; Microdialysis; Nitrophenols; Piperazines; Rats; Rats, Wistar; Time Factors; Tolcapone; Visual Cortex | 1999 |
The effect of serotonin(1A) receptor agonism on antipsychotic drug-induced dopamine release in rat striatum and nucleus accumbens.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Dopamine; Fluorobenzenes; Haloperidol; Male; Microdialysis; Nucleus Accumbens; Piperazines; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Risperidone; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium | 2000 |
The effect of serotonergic agents on haloperidol-induced striatal dopamine release in vivo: opposite role of 5-HT(2A) and 5-HT(2C) receptor subtypes and significance of the haloperidol dose used.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Citalopram; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Fluorobenzenes; Haloperidol; Indoles; Male; Microdialysis; Phenols; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists | 2000 |
In vivo effects of the putative cognitive enhancer KA-672.HCl in comparison with 8-hydroxy-2-(di-N-propylamino) tetralin and haloperidol on dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid levels in striatal and cortical
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Cerebral Cortex; Cognition; Corpus Striatum; Dopamine; Dopamine Antagonists; Haloperidol; Injections, Intraperitoneal; Male; Piperazines; Rats; Serotonin | 2000 |
Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Binding, Competitive; Caudate Nucleus; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Guanidines; Guanosine Triphosphate; Haloperidol; Heterotrimeric GTP-Binding Proteins; Indans; Kinetics; Magnesium; Male; Oxazines; Protein Binding; Putamen; Quinpirole; Raclopride; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Remoxipride; Sodium; Specific Pathogen-Free Organisms; Sulfones; Sulpiride; Tetrahydronaphthalenes | 2001 |
8-OH DPAT can restore the locomotor stimulant effects of cocaine blocked by haloperidol.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Brain Chemistry; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Haloperidol; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Stimulation, Chemical; Time Factors | 2000 |
Repeated treatment with 8-OH-DPAT induces tolerance to its ability to produce the 5-HT1A behavioural syndrome, but not to its ability to attenuate haloperidol-induced catalepsy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Behavior, Animal; Catalepsy; Disease Models, Animal; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Schizophrenia; Serotonin Receptor Agonists; Stereotyped Behavior; Syndrome | 2000 |
Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Amphetamines; Animals; Buspirone; Conditioning, Operant; Dopamine Antagonists; Ethanol; Female; Fenfluramine; Haloperidol; Piperazines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Agents; Serotonin Receptor Agonists | 2000 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
Effects of intrastriatal infusion of D2 and D3 dopamine receptor preferring antagonists on dopamine release in rat dorsal striatum (in vivo microdialysis study).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Clozapine; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Microdialysis; Rats; Rats, Wistar; Receptors, Dopamine D3; Spiperone; Tetrahydronaphthalenes | 2001 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bromocriptine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Fear; Fluvoxamine; Haloperidol; Indophenol; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred ICR; Moclobemide; Motor Activity; Nicotine; Nicotinic Antagonists; Nortriptyline; Physostigmine; Picolinic Acids; Pyrrolidinones; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior; Stress, Psychological | 2001 |
Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aging; Alzheimer Disease; Autopsy; Brain; Catecholamines; Caudate Nucleus; Cerebellum; Dopamine; Haloperidol; Humans; Ketanserin; Lipid Peroxidation; Melatonin; Middle Aged; Postmortem Changes; Prefrontal Cortex; Putamen; Serotonin; Thiobarbituric Acid Reactive Substances | 2001 |
Real-time analysis of dopamine: antagonist interactions at recombinant human D2long receptor upon modulation of its activation state.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alternative Splicing; Animals; Binding, Competitive; Butaclamol; Calcium; CHO Cells; Clozapine; Cricetinae; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Genotype; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Lisuride; Mutation; Plasmids; Receptors, Dopamine; Receptors, Dopamine D2; Recombinant Proteins; Sulfur Radioisotopes; Time Factors | 2001 |
Central 5-HT(4) receptors and dopamine-dependent motor behaviors: searching for a functional role.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Catalepsy; Central Nervous System; Dopamine; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Indoles; Injections, Intraventricular; Male; Morphine; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists; Stereotyped Behavior; Sulfonamides | 2002 |
5-HT(1A) and 5-HT(2A) receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Clozapine; Corpus Striatum; Dopamine Antagonists; Fluorobenzenes; Haloperidol; Indophenol; Male; Microdialysis; Nucleus Accumbens; Piperazines; Piperidines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Time Factors | 2002 |
Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Antidepressive Agents; Antipsychotic Agents; Benzamides; Bridged Bicyclo Compounds, Heterocyclic; Clozapine; Haloperidol; Hippocampus; Imipramine; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Receptors, Serotonin, 5-HT4; Serotonin Antagonists; Serotonin Receptor Agonists | 2002 |
Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animal Diseases; Animals; Animals, Newborn; Borna Disease; Brain; Brain Chemistry; Carrier Proteins; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Fenclonine; Fluoxetine; Genetic Predisposition to Disease; Haloperidol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Norepinephrine; Pregnancy; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Receptors, Neurotransmitter; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Plasma Membrane Transport Proteins | 2002 |
Enhancement of serotonin-1A receptor dependent responses following withdrawal of haloperidol in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basal Ganglia Diseases; Dopamine Antagonists; Drug Administration Schedule; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Synaptic Transmission | 2003 |
Direct activation by dopamine of recombinant human 5-HT1A receptors: comparison with human 5-HT2C and 5-HT3 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Chelating Agents; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Female; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Guanosine Diphosphate; Haloperidol; Humans; Indazoles; Inhibitory Concentration 50; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pertussis Toxin; Piperazine; Piperazines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyridines; Radioligand Assay; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin, 5-HT2; Receptors, Serotonin, 5-HT3; Recombinant Proteins; RNA, Messenger; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spiperone; Thionucleotides; Tropanes; Xenopus laevis | 2003 |
LABORAS: Initial pharmacological validation of a system allowing continuous monitoring of laboratory rodent behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Amphetamine; Angiotensin II; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Feeding Behavior; Haloperidol; Indoles; Injections, Intraventricular; Male; Motor Activity; Piperazines; Psychology, Experimental; Psychotropic Drugs; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2C; Serotonin Antagonists; Serotonin Receptor Agonists | 2003 |
Contribution of the serotonin 5-HT1A receptor agonism of 8-OH-DPAT and EMD 128130 to the regulation of haloperidol-induced muscle rigidity in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiparkinson Agents; Haloperidol; Male; Muscle Rigidity; Organic Chemicals; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists | 2003 |
Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Butyrophenones; Clozapine; Discrimination, Psychological; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Fluorobenzenes; Generalization, Stimulus; Haloperidol; Male; Muscarinic Antagonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Trihexyphenidyl | 2004 |
Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Catalepsy; Chlorpromazine; Dibenzothiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Haloperidol; Hyperkinesis; Injections, Intraperitoneal; Male; Methamphetamine; Mice; Piperazines; Pyridines; Quetiapine Fumarate; Receptor, Serotonin, 5-HT1A; Risperidone; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists | 2004 |
Somatodendritic and postsynaptic serotonin-1A receptors in the attenuation of haloperidol-induced catalepsy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain Chemistry; Buspirone; Catalepsy; Chromatography, High Pressure Liquid; Corpus Striatum; Drug Interactions; Electrochemistry; Haloperidol; Male; Random Allocation; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin | 2004 |
Effects of clozapine, olanzapine and haloperidol on ethanol-induced ascorbic acid release in mouse striatum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Ascorbic Acid; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Clozapine; Dialysis; Ethanol; Haloperidol; Male; Mice; Neostriatum; Olanzapine; Serotonin Receptor Agonists | 2005 |
Effects of novel antipsychotics with mixed D(2) antagonist/5-HT(1A) agonist properties on PCP-induced social interaction deficits in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Dioxanes; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Amino Acid Antagonists; Haloperidol; Interpersonal Relations; Male; Phencyclidine; Piperazines; Pyridines; Quinolones; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Remoxipride; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles; Tropanes | 2005 |
Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; Indoles; Isoindoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT1A; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 2005 |
Effects of OPC-14523, a combined sigma and 5-HT1a ligand, on pre- and post-synaptic 5-HT1a receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Anisoles; Antidepressive Agents; Autoreceptors; Brain; Haloperidol; Hypothalamus; Iontophoresis; Male; Piperazines; Presynaptic Terminals; Propylamines; Pyramidal Cells; Pyridines; Quinolones; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, sigma; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Serotonin Receptor Agonists; Synapses | 2007 |
Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antipsychotic Agents; Aripiprazole; Benzoxazoles; Binding, Competitive; Cell Line; Clozapine; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Humans; Male; Piperazines; Prolactin; Quinolones; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Spodoptera; Sulfur Radioisotopes; Tropanes | 2006 |
Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive somatodendritic serotonergic response by buspirone in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Buspirone; Chromatography, High Pressure Liquid; Dendrites; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Electrochemistry; Exploratory Behavior; Haloperidol; Hydroxyindoleacetic Acid; Male; Motor Activity; Rats; Rats, Wistar; Serotonin; Serotonin Receptor Agonists; Serotonin Syndrome; Stereotyped Behavior | 2007 |
Differential effects of spinal 5-HT1A receptor activation and 5-HT2A/2C receptor desensitization by chronic haloperidol.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Dyskinesia, Drug-Induced; Electrophysiology; Haloperidol; Male; Rats; Rats, Wistar; Receptors, Dopamine D2; Reflex, Monosynaptic; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Receptor Agonists; Spinal Cord | 2007 |
Increase in the effectiveness of somatodendritic 5-HT-1A receptors in a rat model of tardive dyskinesia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Dyskinesia, Drug-Induced; Haloperidol; Male; Mastication; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Receptor Agonists | 2007 |
Evaluation of the antibradykinetic actions of 5-HT1A agonists using the mouse pole test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Fenclonine; Haloperidol; Hypokinesia; Isoindoles; Male; Mice; Motor Activity; Muscarinic Antagonists; Piperazines; Pyrimidines; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Trihexyphenidyl | 2008 |
Anticataleptic 8-OH-DPAT preferentially counteracts with haloperidol-induced Fos expression in the dorsolateral striatum and the core region of the nucleus accumbens.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Catalepsy; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Fenclonine; Gene Expression Regulation; Haloperidol; Male; Mice; Nucleus Accumbens; Oncogene Proteins v-fos; Piperazines; Serotonin Antagonists; Serotonin Receptor Agonists; Statistics, Nonparametric | 2008 |
Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Clozapine; Haloperidol; Inhibition, Psychological; Male; Mice; Mice, Inbred Strains; Olanzapine; Piperazines; Quinolones; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Reflex, Startle; Risperidone; Serotonin Receptor Agonists; Species Specificity | 2008 |
Antidepressant-like effect of 17beta-estradiol: involvement of dopaminergic, serotonergic, and (or) sigma-1 receptor systems.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Benzazepines; Cyclohexanols; Dopamine Antagonists; Dose-Response Relationship, Drug; Estradiol; Haloperidol; Hindlimb Suspension; Male; Mice; Motor Activity; Progesterone; Receptors, Dopamine; Receptors, Serotonin; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Sigma-1 Receptor; Sulpiride; Swimming; Venlafaxine Hydrochloride | 2008 |
Serotonin(1A) receptor agonism in the expression of behavioral dopaminergic supersensitivity in subchronic haloperidol treated rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basal Ganglia Diseases; Behavior, Animal; Brain; Disease Models, Animal; Haloperidol; Locomotion; Male; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine D2; Receptors, Presynaptic; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Serotonin Syndrome; Time Factors; Up-Regulation | 2008 |
Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Aripiprazole; Benzamides; Benzodiazepines; Benzoxazoles; Catalepsy; Clozapine; Dibenzothiazepines; Dioxanes; Dopamine Antagonists; Female; Haloperidol; Macaca fascicularis; Olanzapine; Piperazines; Quetiapine Fumarate; Quinolones; Remoxipride; Risperidone; Serotonin Receptor Agonists; Thiazoles; Tropanes; Video Recording | 2009 |
F15063, a potential antipsychotic with dopamine D(2)/D(3) receptor antagonist and 5-HT(1A) receptor agonist properties: influence on immediate-early gene expression in rat prefrontal cortex and striatum.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Benzofurans; Benzylamines; Clozapine; Cyclopentanes; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Gene Expression Regulation; Genes, Immediate-Early; Haloperidol; Male; Mitogen-Activated Protein Kinase 3; Neostriatum; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Dopamine; Receptors, Dopamine D3; RNA, Messenger; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Time Factors | 2009 |
The modified Geller-Seifter test in rats was insensitive to GABAB receptor positive modulation or blockade, or 5-HT1A receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; GABA Agents; Haloperidol; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Reinforcement Schedule; Reproducibility of Results; Serotonin Receptor Agonists | 2010 |
HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Amphetamines; Animals; Behavior, Animal; Desipramine; Dopamine Agonists; Dopamine Antagonists; Fluoxetine; Haloperidol; Hippocampus; Humans; Hypothalamus; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Piperazines; Quinpirole; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Social Behavior; Syntaxin 1 | 2010 |
Report: Protective effects of rice bran oil in haloperidol-induced tardive dyskinesia and serotonergic responses in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Dyskinesias; Haloperidol; Hydroxyindoleacetic Acid; Male; Neostriatum; Neuroprotective Agents; Plant Oils; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Rice Bran Oil; Serotonin; Tardive Dyskinesia | 2016 |
Co-treatment with imipramine averted haloperidol-instigated tardive dyskinesia: Association with serotonin in brain regions.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Disease Models, Animal; Haloperidol; Imipramine; Male; Mastication; Motor Activity; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin and Noradrenaline Reuptake Inhibitors; Tardive Dyskinesia; Time Factors | 2016 |
The effect of acute and repeated administration of buspirone, 8-OHDPAT and fluoxetine on haloperidol-induced extrapyramidal symptoms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Catalepsy; Fluoxetine; Haloperidol; Male; Pyramidal Cells; Rats; Rats, Wistar | 2019 |
Serotonin 5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antipsychotic Agents; Brain Waves; Cortical Synchronization; Dopamine Agonists; Dopamine Antagonists; Electroencephalography; Fluorobenzenes; Gamma Rhythm; Haloperidol; Hippocampus; Locomotion; Mice; Neural Pathways; Piperazines; Piperidines; Prefrontal Cortex; Pyridines; Quinpirole; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Receptors, Dopamine D2; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists | 2019 |