Compounds > haloperidol

haloperidol and 4-phenyl-1-(4-phenylbutyl)piperidine

haloperidol has been researched along with 4-phenyl-1-(4-phenylbutyl)piperidine in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (43.75)18.2507
2000's4 (25.00)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
el-Ashmawy, MB; Fischer, JB; Glennon, RA; Herndon, JL; Howie, KJ; Ismaiel, AM; Server, AC; Yousif, MY1
Hashimoto, K; Kirsch, JR; Koehler, RC; London, ED; Takahashi, H; Traystman, RJ2
Hashimoto, K; London, ED; Scheffel, U1
Hashimoto, K; Iyo, M; Minabe, Y; Narita, N; Yamazaki, K2
Bhardwaj, A; Crain, B; Harukuni, I; Kirsch, JR; London, ED; Traystman, RJ1
Bhardwaj, A; DeVries, AC; Faraci, FM; Harukuni, I; Hurn, PD; Kirsch, JR; London, ED; Shaivitz, AB; Traystman, RJ1
Bhardwaj, A; Dawson, VL; Goto, S; Goyagi, T; Hurn, PD; Kirsch, JR1
Bhardwaj, A; Goyagi, T; Hurn, PD; Kirsch, JR; Koehler, RC; Traystman, RJ1
Alkayed, NJ; Hurn, PD; Kirsch, JR; Yang, S1
Carter, EL; Koehler, RC; Martin, LJ; Torbey, MT; Yang, ZJ1
Callaway, JK; Crack, PJ; Downes, C; Guio-Aguilar, PL; O'Donovan, L; Tan, F; Zhang, M1
Chen, D; Ding, W; Li, N; Qiao, L; Shi, Y; Sun, Y; Zhang, H; Zhang, Y1
Griesmaier, E; Hermann, M; Kiechl-Kohlendorfer, U; Obermair, GJ; Posod, A; Stanika, RI; Urbanek, M; Wechselberger, K; Wegleiter, K1
Abramyan, AM; Bonifazi, A; Fant, AD; Guthrie, DA; Hong, WC; Newman, AH; Schneck, SN; Shi, L; Xu, M; Yano, H1

Other Studies

16 other study(ies) available for haloperidol and 4-phenyl-1-(4-phenylbutyl)piperidine

ArticleYear
Novel 1-phenylpiperazine and 4-phenylpiperidine derivatives as high-affinity sigma ligands.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:12

    Topics: Animals; Guinea Pigs; In Vitro Techniques; Ligands; Piperazines; Piperidines; Radioligand Assay; Receptors, Dopamine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Structure-Activity Relationship

1991
PPBP [4-phenyl-1-(4-phenylbutyl) piperidine], a potent sigma-receptor ligand, decreases brain injury after transient focal ischemia in cats.
    Stroke, 1995, Volume: 26, Issue:9

    Topics: Animals; Brain; Cats; Caudate Nucleus; Cerebrovascular Circulation; Evoked Potentials, Somatosensory; Haloperidol; Injections, Intravenous; Ischemic Attack, Transient; Ligands; Neuroprotective Agents; Oxygen Consumption; Parietal Lobe; Receptors, sigma; Reperfusion; Staining and Labeling; Temporal Lobe; Tetrazolium Salts

1995
In vivo labeling of sigma receptors in mouse brain with [3H]4-phenyl-1-(4-phenylbutyl)piperidine.
    Synapse (New York, N.Y.), 1995, Volume: 20, Issue:1

    Topics: Animals; Binding, Competitive; Brain Chemistry; Haloperidol; Injections, Intravenous; Ligands; Male; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma

1995
Lack of neuroprotective effect of sigma receptor ligands in the neurotoxicity of p-chloroamphetamine in rat brain.
    European journal of pharmacology, 1995, Oct-06, Volume: 293, Issue:3

    Topics: Animals; Anisoles; Antitussive Agents; Cerebral Cortex; Dextromethorphan; Haloperidol; Hydroxyindoleacetic Acid; Ligands; Male; p-Chloroamphetamine; Propylamines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Serotonin; Serotonin Agents

1995
PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats.
    Stroke, 1996, Volume: 27, Issue:11

    Topics: Animals; Cerebral Infarction; Disease Models, Animal; Haloperidol; Infusions, Intravenous; Ischemic Attack, Transient; Male; Neuroprotective Agents; Rats; Receptors, sigma; Time Factors; Treatment Outcome

1996
Lack of neuroprotective effect of sigma receptor ligands in the neurotoxicity of p-chloroamphetamine in rat brain.
    Annals of the New York Academy of Sciences, 1996, Oct-31, Volume: 801

    Topics: Animals; Brain; Haloperidol; Hydroxyindoleacetic Acid; Ligands; Male; p-Chloroamphetamine; Rats; Rats, Sprague-Dawley; Receptors, sigma; Serotonin

1996
Neuroprotection from focal ischemia by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is dependent on treatment duration in rats.
    Anesthesia and analgesia, 1998, Volume: 87, Issue:6

    Topics: Animals; Brain Ischemia; Cerebral Infarction; Haloperidol; Infusions, Intravenous; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion; Time Factors

1998
sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion.
    Stroke, 2000, Volume: 31, Issue:4

    Topics: Animals; Behavior, Animal; Brain Ischemia; Cerebral Infarction; Drug Administration Schedule; Haloperidol; Ligands; Male; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, sigma; Reperfusion Injury

2000
Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production.
    Stroke, 2001, Volume: 32, Issue:7

    Topics: Animals; Brain; Brain Ischemia; Citrulline; Enzyme Inhibitors; Haloperidol; Indazoles; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor

2001
Potent sigma 1-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine provides ischemic neuroprotection without altering dopamine accumulation in vivo in rats.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Blood Gas Analysis; Body Temperature; Brain Chemistry; Brain Ischemia; Chromatography, High Pressure Liquid; Dopamine; Extracellular Space; Haloperidol; Hemodynamics; Homovanillic Acid; Male; Microdialysis; Middle Cerebral Artery; Neostriatum; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, sigma; Reperfusion Injury; Sigma-1 Receptor

2003
Cyclic adenosine monophosphate response element-binding protein phosphorylation and neuroprotection by 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP).
    Anesthesia and analgesia, 2009, Volume: 108, Issue:3

    Topics: Animals; Blotting, Western; Butadienes; Cell Death; Cell Hypoxia; Cells, Cultured; Chromones; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Glucose; Haloperidol; Isoquinolines; Morpholines; Neurons; Neuroprotective Agents; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Sulfonamides

2009
Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons.
    Experimental neurology, 2010, Volume: 221, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Disks Large Homolog 4 Protein; Dopamine Antagonists; Dose-Response Relationship, Drug; Haloperidol; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Nerve Degeneration; Neurons; Nitric Oxide Synthase Type I; Oxidative Stress; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Swine

2010
The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action.
    Neuropharmacology, 2010, Volume: 59, Issue:6

    Topics: Analysis of Variance; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Haloperidol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurons; Neuroprotective Agents; Phosphorylation; Receptors, sigma

2010
Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in bcl-2 expression in mouse neuronal cultures.
    Brain research, 2012, Jan-11, Volume: 1431

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Brain; Carbazoles; Cell Survival; Cells, Cultured; DNA Fragmentation; Dose-Response Relationship, Drug; Embryo, Mammalian; Gene Expression Regulation; Haloperidol; HIV Envelope Protein gp120; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Neurites; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Receptors, sigma; RNA, Messenger; Sigma-1 Receptor; Statistics, Nonparametric

2012
The sigma-1 receptor agonist 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) protects against newborn excitotoxic brain injury by stabilizing the mitochondrial membrane potential in vitro and inhibiting microglial activation in vivo.
    Experimental neurology, 2014, Volume: 261

    Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Inducing Factor; Brain Injuries; Caspase 3; Disease Models, Animal; Excitatory Amino Acid Agonists; Glutamic Acid; Glycoproteins; Haloperidol; Hippocampus; Ibotenic Acid; Membrane Potential, Mitochondrial; Mice; Microglia; Neurons; Receptors, sigma; Sigma-1 Receptor; Statistics, Nonparametric

2014
Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.
    Neuropharmacology, 2018, 05-01, Volume: 133

    Topics: Animals; Bioluminescence Resonance Energy Transfer Techniques; Cerebral Cortex; Dopamine Antagonists; Guinea Pigs; Haloperidol; HEK293 Cells; Humans; Isoxazoles; Ligands; Male; Molecular Docking Simulation; Pentazocine; Protein Binding; Protein Conformation; Pyridines; Receptors, sigma; Sigma-1 Receptor; Transfection; Tritium

2018