haloperidol and 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol

haloperidol has been researched along with 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (11.48)	18.7374
1990's	37 (60.66)	18.2507
2000's	8 (13.11)	29.6817
2010's	5 (8.20)	24.3611
2020's	4 (6.56)	2.80

Authors

Authors	Studies
Childers, SR; Hammond, PS; Huang, Y; Kuhner, RJ; Mach, RH; Whirrett, BR; Wu, L	1
Hammond, PS; Huang, Y; Mach, RH; Wu, L	1
Bernardini, R; Fiorito, J; Marrazzo, A; Pasquinucci, L; Prezzavento, O; Ronsisvalle, G; Ronsisvalle, S; Scoto, GM; Zappalà, L	1
Cacciatore, I; Cataldi, A; Di Giacomo, V; Di Stefano, A; Fiorito, J; Marinelli, L; Marrazzo, A; Pacella, S; Parenti, C; Rescifina, A; Sozio, P; Turkez, H	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Amata, E; Anfuso, CD; Arena, E; Caporarello, N; Drago, F; Fiorito, J; Giurdanella, G; Lupo, G; Marrazzo, A; Olivieri, M; Prezzavento, O; Rescifina, A; Salerno, L; Vinciguerra, S	1
Amata, E; Anfuso, CD; Barbaraci, C; Cacciatore, I; Dichiara, M; Giurdanella, G; Leotta, CG; Longo, A; Lupo, G; Marrazzo, A; Pasquinucci, L; Pitari, GM; Prezzavento, O; Turnaturi, R; Zuccarello, E	1
Amata, E; Artacho-Cordón, A; Barbaraci, C; Cobos, EJ; Dichiara, M; Gómez-Guzmán, M; González-Cano, R; Marrazzo, A; Pasquinucci, L; Rodríguez-Gómez, I; Santos-Caballero, M; Turnaturi, R	1
Casanova, MF; Jaskiw, GE; Kleinman, JE; Kolachana, B; Laruelle, M; Lipska, BK; Weinberger, DR	1
Gaertner, HJ; Mahal, A; Stevens, A	1
Bertilsson, L; Dahl, ML; Ekqvist, B; Llerena, A	2
Hasegawa, K; Hirayama, H; Matsuno, H; Nakashima, M; Sato, H; Uematsu, T	1
Gaertner, HJ; Mahal, A; Stevens, A; Stevens, I	1
Chang, WH	1
Dysken, MW; Holden, L; Johnson, SB; Kim, SW; Skare, S; Thomsyck, L; Vatassery, G	1
Cooper, TB; Czobor, P; Volavka, J	1
Chang, WH; Chen, H; Jann, MW; Lam, YW	1
Chang, WH; Chen, H; Chen, TY; Chien, CP; Davis, CM; Hwu, HG; Jann, MW; Lam, YW; Lin, HN; Lin, SK	1
Inaba, T; Noguchi, T; Shibasaki, M; Someya, T; Takahashi, S	1
Dysken, MW; Holden, L; Johnson, SB; Kuskowski, M; Ofstehage, J; Skare, S; Vatassery, G	1
Inaba, T; Kalow, W; Tyndale, RF	1
Chang, WH; Jann, MW; Lin, SK	1
Cahard, C; Conquy, T; Rop, PP; Viala, A	1
Cheung, SW; Inaba, T; Shibasaki, M; Someya, T; Takahashi, S; Tang, SW	1
Shibasaki, M; Someya, T; Takahashi, S	2
Egan, M; Freedman, R; Kirch, DG; Palmer, MR	1
Chang, WH; Tseng, YT; Wu, HS	1
Chang, WH; Chen, TY; Hu, WH; Lee, CF; Yeh, EK	1
Hawes, EM; Hubbard, JW; Korchinski, ED; McKay, G; Midha, KK	1
Browning, JL; Davis, CM; Harrington, CA	1
Costakos, DT; Kleinman, JE; Korpi, ER; Linnoila, M; Wyatt, RJ	1
Knorr, W; Meyer, FP; Neuhof, S; Ulrich, S	1
Eyles, DW; Pond, SM; Stedman, TJ	1
Chang, WH; Chien, CP; Jann, MW; Liu, HC; Shieh, YS	1
Aravagiri, M; Marder, SR; Marshall, BD; Van Putten, T	1
Bouhours, P; Elia, E; Erb, F; Jacquet, M; Leroux, JM; Levron, JC; Pommery, J; Sechter, D	1
Chang, WH; Chen, LC; Chien, CP; Hu, WH; Jann, MW; Juang, DJ; Lam, YF; Lin, SK; Yang, CH	1
Chang, WH; Chen, LC; Chien, CP; Hu, WH; Jann, MW; Juang, DJ; Lam, YW; Lin, SK; Yang, CH	1
Chang, WH; Chiang, TS; Chien, CP; Hu, WH; Jann, MW; Lin, HN	1
Castagnoli, N; Fukui, M; Idzu, T; Igarashi, K; Kasuya, F; Matsubara, K	1
Dupuy, JL; Hoja, H; Lachâtre, G; Lotfi, H; Marquet, P; Pénicaut, B; Verneuil, B	1
Carter, JG; Crabtree, BL; Jann, MW; Lam, YW; Pitts, WM	1
Chang, WH; Chang, YC; Hu, OY; Hu, WH; Jann, MW; Lane, HY; Lin, HN	1
Eyles, DW; McGrath, JJ; Pond, SM; Stedman, TJ	1
Belpaire, FM; De Vriendt, C; Pan, LP	1
Han, CS; Kim, SH; Lee, MS; You, YW	1
Braun, V; Meyer, FP; Neuhof, S; Ulrich, S	1
Belpaire, FM; Berlo, JA; De Schepper, N; Pan, L; Rosseel, MT; Vander Stichele, R	1
Belpaire, FM; Pan, L	1
Furukori, H; Inoue, Y; Kaneko, S; Kondo, T; Mihara, K; Nagashima, U; Ono, S; Otani, K; Suzuki, A; Yasui, N	1
Flockhart, DA; Kane, K; Shin, JG	1
Fujita, R; Furusawa, S; Ishikawa, M; Kataoka, Y; Miura, M; Sasaki, K; Takayanagi, M; Takayanagi, Y; Takeshita, M	1
Arinobu, T; Hattori, H; Ishii, A; Seno, H; Suzuki, O	1
Furukori, H; Inoue, Y; Kaneko, S; Kondo, T; Mihara, K; Otani, K; Suzuki, A; Yasui-Furukori, N	1
Hamachi, C; Imamura, Y; Kishikawa, N; Kuroda, N; Nakashima, K; Ohba, Y; Tagawa, Y	1
Baeyens, JM; Cendán, CM; Cobos, EJ; Del Pozo, E; Entrena, JM; Nieto, FR	1
Fang, J; Song, J	1
Ishii, A; Natori, Y; Yamamoto, T; Yoshimoto, T	1
Chen, Z; Gao, RD; Gori, SS; LaPorte, HM; Luedtke, RR; Mach, RH; McInnis, T; Neisewander, JL; Rais, R; Siegler, MA; Singh, M; Slusher, BS; Taylor, M; Tsukamoto, T	1

Reviews

1 review(s) available for haloperidol and 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol

Article	Year
Reduced haloperidol: a factor in determining the therapeutic benefit of haloperidol treatment? Psychopharmacology, 1992, Volume: 106, Issue:3 Topics: Animals; Haloperidol; Humans; Schizophrenia	1992

Trials

11 trial(s) available for haloperidol and 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol

Article	Year
Haloperidol and lorazepam combined: clinical effects and drug plasma levels in the treatment of acute schizophrenic psychosis. Pharmacopsychiatry, 1992, Volume: 25, Issue:6 Topics: Acute Disease; Adult; Drug Therapy, Combination; Female; Haloperidol; Humans; Lorazepam; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1992
Plasma drug level and clinical response. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:2 Topics: Chronic Disease; Dose-Response Relationship, Drug; Haloperidol; Humans; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1992
Megabore capillary gas-liquid chromatographic method with nitrogen-phosphorus selective detection for the assay of haloperidol and reduced haloperidol in serum: results of therapeutic drug-monitoring during acute therapy of eight schizophrenics. Journal of chromatography. B, Biomedical applications, 1995, Jan-20, Volume: 663, Issue:2 Topics: Adult; Chromatography, Gas; Drug Monitoring; Female; Haloperidol; Humans; Male; Middle Aged; Schizophrenia	1995
Nonlinear relationship between circulating concentrations of reduced haloperidol and haloperidol: evaluation of possible mechanisms. Psychopharmacology, 1994, Volume: 116, Issue:2 Topics: Adolescent; Adult; Aged; Blood Proteins; Chronic Disease; Cytosol; Erythrocytes; Female; Haloperidol; Humans; Hydrogen-Ion Concentration; Ketone Oxidoreductases; Liver; Male; Microsomes, Liver; Middle Aged; Protein Binding; Schizophrenia; Stereoisomerism	1994
Plasma reduced haloperidol/haloperidol ratios in schizophrenic patients treated with high dosages of haloperidol. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1994, Volume: 4, Issue:2 Topics: Adult; Chronic Disease; Dose-Response Relationship, Drug; Drug Resistance; Haloperidol; Humans; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia	1994
Simultaneous determination of plasma haloperidol and its metabolite reduced haloperidol by liquid chromatography with electrochemical detection. Plasma levels in schizophrenic patients treated with oral or intramuscular depot haloperidol. Journal of chromatography. B, Biomedical applications, 1994, Jun-17, Volume: 656, Issue:2 Topics: Administration, Oral; Chromatography, Liquid; Delayed-Action Preparations; Drug Resistance; Electrochemistry; Haloperidol; Humans; Injections, Intramuscular; Schizophrenia	1994
Plasma alpha-one acid glycoprotein and haloperidol concentrations in schizophrenic patients. Neuropsychobiology, 1997, Volume: 36, Issue:1 Topics: Adult; Antipsychotic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Middle Aged; Neurologic Examination; Orosomucoid; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1997
Chirality of reduced haloperidol in humans. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1998, Volume: 8, Issue:2 Topics: Adult; Antipsychotic Agents; Chromatography, High Pressure Liquid; Haloperidol; Humans; Male; Middle Aged; Oxidation-Reduction; Stereoisomerism	1998
Co-administration of sertraline and haloperidol. Psychiatry and clinical neurosciences, 1998, Volume: 52 Suppl Topics: Adult; Aged; Antidepressive Agents; Antipsychotic Agents; Drug Interactions; Drug Therapy, Combination; Female; Haloperidol; Humans; Male; Metabolic Clearance Rate; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Sertraline	1998
Reduced haloperidol does not interfere with the antipsychotic activity of haloperidol in the treatment of acute schizophrenia. International clinical psychopharmacology, 1999, Volume: 14, Issue:4 Topics: Acute Disease; Adult; Antipsychotic Agents; Basal Ganglia Diseases; Dose-Response Relationship, Drug; Drug Interactions; Female; Haloperidol; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia	1999
Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol. Therapeutic drug monitoring, 2003, Volume: 25, Issue:2 Topics: Adult; Aged; Antipsychotic Agents; Cyclizine; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; Haloperidol; Histamine H1 Antagonists; Humans; Male; Middle Aged; Promethazine; Schizophrenia	2003

Other Studies

49 other study(ies) available for haloperidol and 4-(4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanol

Article	Year
Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands. Journal of medicinal chemistry, 1998, Jun-18, Volume: 41, Issue:13 Topics: Acetamides; Acetanilides; Animals; Benzamides; Brain; Guinea Pigs; Ligands; Liver; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Structure-Activity Relationship	1998
Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Acetamides; Animals; Brain; Fluorine; Guinea Pigs; In Vitro Techniques; Iodine; Ligands; Liver; Models, Molecular; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Structure-Activity Relationship	2001
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Animals; Cell Line, Tumor; Cell Proliferation; Guinea Pigs; Haloperidol; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Male; Phenylbutyrates; Prostatic Neoplasms; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, sigma	2011
Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells. European journal of medicinal chemistry, 2015, Jan-27, Volume: 90 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glioma; Haloperidol; Molecular Structure; Prodrugs; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	2015
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
Antiangiogenic Effect of (±)-Haloperidol Metabolite II Valproate Ester [(±)-MRJF22] in Human Microvascular Retinal Endothelial Cells. Journal of medicinal chemistry, 2016, 11-10, Volume: 59, Issue:21 Topics: Angiogenesis Inhibitors; Cell Survival; Dose-Response Relationship, Drug; Endothelial Cells; Haloperidol; Humans; Microvessels; Molecular Structure; Neovascularization, Physiologic; Retina; Structure-Activity Relationship; Valproic Acid	2016
Haloperidol Metabolite II Valproate Ester ( Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18 Topics: Angiogenesis Inhibitors; Butyrophenones; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Melanoma; Pentanoic Acids; Piperidines; Prodrugs; Stereoisomerism; Uveal Neoplasms; Valerates	2021
Dual Sigma-1 receptor antagonists and hydrogen sulfide-releasing compounds for pain treatment: Design, synthesis, and pharmacological evaluation. European journal of medicinal chemistry, 2022, Feb-15, Volume: 230 Topics: Animals; Guinea Pigs; Hydrogen; Hydrogen Sulfide; Ligands; Male; Morpholines; Pain; Piperazines; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor	2022
D1 and D2 receptor modulation in rat striatum and nucleus accumbens after subchronic and chronic haloperidol treatment. Brain research, 1992, Mar-13, Volume: 575, Issue:1 Topics: Animals; Cerebellum; Chromatography, High Pressure Liquid; Corpus Striatum; Haloperidol; Male; Motor Activity; Nucleus Accumbens; Radioligand Assay; Rats; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Time Factors	1992
Haloperidol and reduced haloperidol serum levels: correlation with psychopathology in acute schizophrenia. Pharmacopsychiatry, 1992, Volume: 25, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Haloperidol; Humans; Middle Aged; Psychiatric Status Rating Scales; Regression Analysis; Schizophrenia; Schizophrenic Psychology	1992
Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers. Therapeutic drug monitoring, 1992, Volume: 14, Issue:3 Topics: Chromatography, High Pressure Liquid; Debrisoquin; Haloperidol; Humans; Hydroxylation; Oxidation-Reduction; Phenotype	1992
Steady-state pharmacokinetics of haloperidol and reduced haloperidol in schizophrenic patients: analysis of factors determining their concentrations in hair. Journal of pharmaceutical sciences, 1992, Volume: 81, Issue:10 Topics: Administration, Oral; Adult; Aged; Chromatography, High Pressure Liquid; Female; Hair; Haloperidol; Humans; Male; Middle Aged; Schizophrenia	1992
Genetic factors in the metabolism of haloperidol. Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A Topics: Debrisoquin; Half-Life; Haloperidol; Humans; Hydroxylation; Phenotype	1992
Haloperidol decanoate pharmacokinetics in red blood cells and plasma. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:2 Topics: Adult; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Erythrocytes; Female; Haloperidol; Humans; Male; Metabolic Clearance Rate; Psychiatric Status Rating Scales; Psychotic Disorders	1992
Pharmacokinetics of haloperidol and reduced haloperidol in Chinese schizophrenic patients after intravenous and oral administration of haloperidol. Psychopharmacology, 1992, Volume: 106, Issue:4 Topics: Administration, Oral; Adult; Biological Availability; China; Chromatography, High Pressure Liquid; Half-Life; Haloperidol; Humans; Injections, Intravenous; Male; Middle Aged; Models, Biological; Schizophrenia	1992
Comparison of haloperidol and reduced haloperidol plasma levels in four different ethnic populations. Progress in neuro-psychopharmacology & biological psychiatry, 1992, Volume: 16, Issue:2 Topics: Black or African American; Black People; China; Chromatography, Liquid; Ethnicity; Haloperidol; Hispanic or Latino; Humans; Psychiatric Status Rating Scales; Radioimmunoassay; Schizophrenia; United States; White People	1992
Haloperidol metabolism in psychiatric patients: importance of glucuronidation and carbonyl reduction. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:3 Topics: Adolescent; Adult; Alcohol Oxidoreductases; Chromatography, High Pressure Liquid; Erythrocytes; Female; Glucuronates; Haloperidol; Humans; Male; Mental Disorders; Middle Aged; Oxidation-Reduction	1992
Haloperidol and reduced haloperidol in saliva and blood. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:3 Topics: Adult; Aged; Chromatography, High Pressure Liquid; Erythrocytes; Female; Haloperidol; Humans; Male; Mental Disorders; Middle Aged; Parotid Gland; Saliva	1992
Oxidation of reduced haloperidol to haloperidol: involvement of human P450IID6 (sparteine/debrisoquine monooxygenase). British journal of clinical pharmacology, 1991, Volume: 31, Issue:6 Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Haloperidol; Humans; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Quinidine; Quinine	1991
Interconversions between haloperidol and reduced haloperidol in schizophrenic patients and guinea pigs: a steady-state study. Journal of clinical psychopharmacology, 1991, Volume: 11, Issue:2 Topics: Adult; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Guinea Pigs; Haloperidol; Humans; Male; Middle Aged; Schizophrenia; Schizophrenic Psychology	1991
High-performance liquid chromatographic analysis of haloperidol and hydroxyhaloperidol in plasma after solid-phase extraction. Journal of chromatography, 1990, Oct-26, Volume: 532, Issue:1 Topics: Chromatography, High Pressure Liquid; Haloperidol; Humans; Quality Control	1990
Reduced haloperidol/haloperidol ratios in plasma: polymorphism in Japanese psychiatric patients. Psychiatry research, 1990, Volume: 31, Issue:2 Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Japan; Male; Mental Disorders; Middle Aged	1990
[The plasma levels of haloperidol and reduced haloperidol in Japanese psychiatric patients]. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1989, Volume: 9, Issue:2 Topics: Adolescent; Adult; Aged; Asian People; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Japan; Male; Mental Disorders; Middle Aged	1989
Electrophysiological interactions between haloperidol and reduced haloperidol, and dopamine, norepinephrine and phencyclidine in rat brain. Neuropharmacology, 1985, Volume: 24, Issue:5 Topics: Animals; Antipsychotic Agents; Brain; Catecholamines; Dopamine Antagonists; Haloperidol; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Synaptic Transmission	1985
Reduced haloperidol and haloperidol: effects on homovanillic acid in caudate and prefrontal cortex. Biological psychiatry, 1987, Volume: 22, Issue:11 Topics: Animals; Caudate Nucleus; Dose-Response Relationship, Drug; Frontal Lobe; Haloperidol; Homovanillic Acid; Male; Rats; Rats, Inbred Strains	1987
Low plasma reduced haloperidol/haloperidol ratios in Chinese patients. Biological psychiatry, 1987, Volume: 22, Issue:11 Topics: China; Ethnicity; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1987
Interconversion between haloperidol and reduced haloperidol in humans. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:5 Topics: Haloperidol; Humans	1987
Quantification of reduced haloperidol and haloperidol by radioimmunoassay. Journal of immunoassay, 1985, Volume: 6, Issue:1-2 Topics: Chromatography, Liquid; Cross Reactions; Haloperidol; Humans; Radioimmunoassay; Schizophrenia	1985
Reduced haloperidol in the post-mortem brains of haloperidol-treated patients. Psychiatry research, 1984, Volume: 11, Issue:3 Topics: Adult; Animals; Brain Chemistry; Cerebellum; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Female; Haloperidol; Humans; Liver; Male; Middle Aged; Occipital Lobe; Rats; Rats, Inbred Strains; Schizophrenia	1984
Correlation of clinical response (PANSS) and plasma levels of haloperidol and reduced haloperidol in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:2 Topics: Adult; Chromatography, High Pressure Liquid; Female; Haloperidol; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia, Paranoid; Schizophrenic Psychology; Spectrophotometry, Ultraviolet	1994
Reduced haloperidol/haloperidol ratios after oral haloperidol and decanoate administration in schizophrenics. Progress in neuro-psychopharmacology & biological psychiatry, 1993, Volume: 17, Issue:1 Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Female; Haloperidol; Humans; Male; Middle Aged; Regression Analysis; Schizophrenia	1993
Relation of plasma and red blood cells reduced haloperidol concentrations to haloperidol reductase activity assayed in red blood cells in psychiatric population. Progress in neuro-psychopharmacology & biological psychiatry, 1993, Volume: 17, Issue:2 Topics: Adolescent; Adult; Alcohol Oxidoreductases; Erythrocytes; Female; Haloperidol; Humans; Japan; Male; Middle Aged; Psychotic Disorders	1993
Prolonged haloperidol and reduced haloperidol plasma concentrations after decanoate withdrawal. Schizophrenia research, 1993, Volume: 9, Issue:1 Topics: Adult; Female; Half-Life; Haloperidol; Humans; Injections, Intramuscular; Male; Metabolic Clearance Rate; Middle Aged; Schizophrenia; Schizophrenic Psychology; Substance Withdrawal Syndrome	1993
Plasma haloperidol and reduced haloperidol concentrations in a geriatric population. Neuropsychobiology, 1996, Volume: 33, Issue:1 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Bipolar Disorder; Dementia; Dose-Response Relationship, Drug; Female; Haloperidol; Humans; Male; Metabolic Clearance Rate; Middle Aged; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology	1996
Effect of a pyridinium metabolite derived from haloperidol on the activities of striatal tyrosine hydroxylase in freely moving rats. Neuroscience letters, 1996, Aug-23, Volume: 214, Issue:2-3 Topics: 1-Methyl-4-phenylpyridinium; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Dopamine Agents; Enzyme Inhibitors; Haloperidol; Hydrazines; Hydroxyindoleacetic Acid; Male; Microdialysis; Neostriatum; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase	1996
Determination of haloperidol and its reduced metabolite in human plasma by liquid chromatography-mass spectrometry with electrospray ionization. Journal of chromatography. B, Biomedical sciences and applications, 1997, Jan-24, Volume: 688, Issue:2 Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Electrochemistry; Haloperidol; Humans; Mass Spectrometry; Reproducibility of Results	1997
Dose-dependent reduced haloperidol/haloperidol ratios: influence of patient-related variables. Psychiatry research, 1997, Sep-19, Volume: 72, Issue:2 Topics: Adult; Age Factors; Antipsychotic Agents; Body Weight; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Metabolic Clearance Rate; Middle Aged; Schizophrenia; Sex Factors	1997
In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol. Pharmacogenetics, 1998, Volume: 8, Issue:5 Topics: Adolescent; Adult; Aged; Child; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Haloperidol; Humans; Isoenzymes; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Piperidines	1998
Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients. Therapeutic drug monitoring, 1999, Volume: 21, Issue:5 Topics: Adult; Aged; Antipsychotic Agents; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Enzyme Induction; Enzyme Inhibitors; Genotype; Haloperidol; Humans; Inpatients; Middle Aged; Polymorphism, Genetic; Polypharmacy; Schizophrenia; Smoking	1999
In vitro study on the involvement of CYP1A2, CYP2D6 and CYP3A4 in the metabolism of haloperidol and reduced haloperidol. European journal of clinical pharmacology, 1999, Volume: 55, Issue:8 Topics: Biotransformation; Child; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dopamine Antagonists; Enzyme Inhibitors; Haloperidol; Humans; Isoenzymes; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Oxidation-Reduction; Theophylline	1999
Effect of a genetic polymorphism of CYP1A2 inducibility on the steady state plasma concentrations of haloperidol and reduced haloperidol in Japanese patients with schizophrenia. Therapeutic drug monitoring, 2000, Volume: 22, Issue:3 Topics: Alleles; Antipsychotic Agents; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Enzyme Induction; Female; Genotype; Haloperidol; Humans; Male; Middle Aged; Point Mutation; Polymorphism, Genetic; Schizophrenia; Smoking	2000
Potent inhibition of CYP2D6 by haloperidol metabolites: stereoselective inhibition by reduced haloperidol. British journal of clinical pharmacology, 2001, Volume: 51, Issue:1 Topics: Binding, Competitive; Biomarkers; Cytochrome P-450 CYP2D6 Inhibitors; Dextrorphan; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Haloperidol; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Phenols; Propanols; Stereoisomerism	2001
Reversal of vinblastine resistance in human leukemic cells by haloperidol and dihydrohaloperidol. Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:6 Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Resistance, Neoplasm; Drug Synergism; Haloperidol; Humans; Leukemia; Photoaffinity Labels; Tumor Cells, Cultured; Vinblastine	2001
Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites. Journal of the American Society for Mass Spectrometry, 2002, Volume: 13, Issue:3 Topics: Antipsychotic Agents; Biotransformation; Chromatography, High Pressure Liquid; Haloperidol; Humans; Mass Spectrometry; Pharmaceutical Preparations; Piperidines; Ultrasonics	2002
Determination of haloperidol and reduced haloperidol in human serum by liquid chromatography after fluorescence labeling based on the Suzuki coupling reaction. Analytical and bioanalytical chemistry, 2006, Volume: 386, Issue:3 Topics: Boron Compounds; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Fluorescence; Haloperidol; Humans; Male; Molecular Structure; Oxidation-Reduction; Reference Values; Reproducibility of Results; Schizophrenia; Sensitivity and Specificity	2006
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors. Psychopharmacology, 2009, Volume: 205, Issue:1 Topics: Analysis of Variance; Animals; Brain; Capsaicin; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Hyperalgesia; Mice; Morpholines; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Pentazocine; Physical Stimulation; Protein Binding; Radioligand Assay; Reaction Time; Receptors, sigma; Rotarod Performance Test; Sigma-1 Receptor; Tritium	2009
In vitro characterization of the oxidation of a pyridinium metabolite of haloperidol by human placenta: the effect of smoking. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2012, Volume: 15, Issue:4 Topics: Antipsychotic Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Female; Haloperidol; Humans; Microsomes; Microsomes, Liver; Oxidation-Reduction; Placenta; Pregnancy; Pyridinium Compounds; Smoking	2012
Identification and quantification of diphenhydramine, haloperidol, and its metabolite, reduced haloperidol in a saponified brain specimen that was immersed in the sea water for more than 10 years. Legal medicine (Tokyo, Japan), 2023, Volume: 61 Topics: Brain; Diphenhydramine; Haloperidol; Humans; Seawater; Tandem Mass Spectrometry	2023
Synthesis and Pharmacological Characterization of a Difluorinated Analogue of Reduced Haloperidol as a Sigma-1 Receptor Ligand. ACS chemical neuroscience, 2023, 03-01, Volume: 14, Issue:5 Topics: Animals; Brain-Derived Neurotrophic Factor; Haloperidol; Ligands; Mice; Receptors, sigma; Sigma-1 Receptor	2023