halofantrine has been researched along with phenanthrenes in 410 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (8.05) | 18.7374 |
| 1990's | 225 (54.88) | 18.2507 |
| 2000's | 108 (26.34) | 29.6817 |
| 2010's | 40 (9.76) | 24.3611 |
| 2020's | 4 (0.98) | 2.80 |
| Authors | Studies |
|---|---|
| Baudon, D; Bernard, J; Lantrade, P; Martet, G; Mouliat-Pelat, JP; Picq, JJ; Sarrouy, J; Spiegel, A; Touzé, JE | 1 |
| Badoual, J | 1 |
| Bokor, LC; Horton, RJ; Parr, SN | 2 |
| Charmot, G; Coulaud, JP; Fajac, I; Gachot, B; Vachon, F | 1 |
| Kager, PA | 1 |
| Bryson, HM; Goa, KL | 1 |
| Chutmongkonkul, M; Maier, WA; Seitz, HM | 2 |
| Mberu, EK; Muhia, DK; Watkins, WM | 1 |
| Basco, LK; Le Bras, J | 3 |
| Cheng, KN; Elsom, LF; Hawkins, DR | 1 |
| Baziomo, JM; Gendrel, C; Gendrel, D; Kombila, M; Lecointre, C; Martz, M; Nardou, M; Richard-Lenoble, D | 1 |
| Fadat, G; Gardon, J; Gazin, P; Hengy, C; Jambou, R; Louis, FJ; Louis, JP; Trebucq, A | 1 |
| Jatapadma, S; Ketrangsee, S; Rooney, W; Thimasarn, K; Vijaykadga, S; Yamokgul, P | 1 |
| Bustos, MD; Ciceron, L; Danis, M; Gay, F; Gentilini, M; Pichet, C; Rojas-Rivero, L | 1 |
| Basco, LK; Farinotti, R; Gillotin, C; Gimenez, F; Le Bras, J | 1 |
| Becquart, JP; Le Bras, M; Nordor, O; Receveur, MC; Vincent, MP | 1 |
| Clavin, AM; Coleman, RE; Milhous, WK | 1 |
| Blanc, G; Dupasquier, I; Engohan, E; Gendrel, C; Gendrel, D; Iannascoli, F; Kombila, M; Martz, M; Moreno, JL; Richard-Lenoble, D | 1 |
| Bock, HL; Clemens, R; Fleischer, K; Kohler, B; Kretschmer, H; Loscher, T; Pohle, HD; Schlunk, T; Weinke, T | 1 |
| Chuanak, N; Sookto, P; Thimasarn, K; Webster, HK; Wernsdorfer, WH; Wimonwattrawatee, T; Wongsrichanalai, C | 1 |
| Bauchet, J; Hatin, I; Le Bras, J; Legros, F; Trape, JF | 1 |
| Basco, LK; Bouchaud, O; Coulaud, JP; Farinotti, R; Gillotin, C; Gimenez, F; Le Bras, J; Rabenjarson, E; Ringwald, P | 1 |
| Kidson, C | 1 |
| Edstein, MD; Kere, N; Parkinson, AD; Rieckmann, KH; Veenendaal, JR | 1 |
| Baudon, D; Cordoliani, G; Da Conceicao, S; Delolme, H; Doury, JC; Hovette, P; Lecamus, JL; Martet, G; Raphenon, G; Touze, JE | 1 |
| Bah, IB; Diallo, S; Dieng, T; Faye, O; Gaye, O; Konate, L; Legros, C; Trape, JF | 1 |
| Bustos, DG; Carlos, CC; Quiambao, BP; Salazar, NP; Saniel, MC; Santos, MN | 1 |
| Trigg, PI | 1 |
| Abila, B; Ambakederemo, AW; Ezeamuzie, IC; Igbigbi, PS; Nwaejike, IN | 1 |
| Khan, MA; Qazi, SA; Rehman, GN | 1 |
| Edstein, MD; Kowinwiphat, W; Panpunnung, S; Shanks, GD; Suriyamongkol, V; Watanasook, C; Watt, G; Webster, HK | 1 |
| Edwards, G; Karbwang, J; Milton, KA; Na Bangchang, K; Ward, SA | 1 |
| Coulaud, JP; LeBras, J; Ringwald, P; Voyer, C | 1 |
| Baudon, D; Bernard, J; Lantrade, P; Martet, G; Moulia-Pelat, JP; Picq, JJ; Sarrouy, J; Spiegel, A; Touze, JE | 1 |
| Bustos, DG; Danis, M; Diquet, B; Gay, F; Gentilini, M; Litaudon, M; Pichet, C; Rojas Rivero, L | 1 |
| Bunnag, D; Edwards, G; Karbwang, J; Milton, KA; Na Bangchang, K; Ward, SA | 1 |
| Edstein, MD; Keeratithakul, D; Shanks, GD; Teja-Isavadharm, P; Webster, HK | 1 |
| Bourdeau, EF; Childs, GE; Milhous, WK; Pang, L; Wimonwattratee, T | 1 |
| Le Bras, M; Mazaudier, E; Raccurt, CP; Ripert, C; Schmitt, A | 1 |
| Becker, JM; Bernard, J; Dupasquier, I; Geffray, L; Gimenez, M; Jourdan, G; Lesbordes, JL; Molinas, JM; Sarrouy, J | 1 |
| Jeandel, P; Touze, JE | 1 |
| Bustos, MD; Danis, M; Diquet, B; Félix, R; Gay, F; Gentilini, M; Lyogoubi, A | 1 |
| Kayembe, N; Kingway, MP; Mashako, MN | 1 |
| Rooney, W; Schildbach, S; Suebsaeng, L; Wernsdorfer, WH | 1 |
| Bustos, D; Caumes, E; Danis, M; Datry, A; Diquet, B; Gay, F; Gentilini, M; Litaudon, M | 1 |
| Edwards, G; Hoaksey, PE; Milton, KA; Ward, SA | 1 |
| Salako, LA; Sowunmi, A; Walker, O | 1 |
| Hallwood, PM; Horton, RJ; O'Sullivan, KM; Parr, SN | 1 |
| Karle, IL; Karle, JM | 1 |
| Bouloumie, J; Lambert, MT; Macaigne, F; Raccurt, CP; Ribou, G; Ripert, C | 1 |
| Breckenridge, AM; Edwards, G; Milton, KA; Orme, ML; Ward, SA | 1 |
| Camilleri, P; Dyke, C; Hossner, F | 1 |
| Coulaud, JP; Ngo Van, P | 1 |
| Gilles, HM; Kariuki, D; Koech, DK; Lury, JD; Mjomba, M; Mosoba, M; Oloo, JA; Watkins, WM | 1 |
| Gilles, HM; Khoromana, C; Molyneux, ME; Wirima, J | 1 |
| Carles, G; John, M; Joly, F; Maisonneuve, H; Rossignol, JF | 1 |
| Bowdre, JH; Desjardins, RE; Milhous, WK; Oduola, AM; Weatherly, NF | 1 |
| Chanthavanich, P; Karbwang, J; Looareesuwan, S; Phillips, RE; Supanaranond, W; Turner, RC; Warrell, DA; White, NJ | 1 |
| Benet, LZ; Fleckenstein, L; Gawienowski, M; Lin, ET | 1 |
| Edwards, G; Milton, KA; Ward, SA | 1 |
| Blauer, G | 1 |
| Childs, GE; Pooyindee, N; Wimonwattrawatee, T | 1 |
| Boudreau, EF; Canfield, CJ; Dixon, KE; Pang, LW; Pavanand, K; Somutsakorn, P; Tosingha, L; Webster, HK | 1 |
| Ellis, DS; Peters, W; Robinson, BL | 1 |
| Coulaud, JP; Le Bras, J; Matheron, S; Moriniere, B; Rossignol, JF; Saimot, AG | 2 |
| Boudreau, EF; Pang, LW; Pavanand, K; Webster, HK; Yongvanitchit, K | 1 |
| Canfield, CJ; Cosgriff, TM; Pamplin, CL; Willet, GP | 1 |
| Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA | 1 |
| Biaud, JM; Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA | 1 |
| Boudreau, EF; Pavanand, K; Pinswasdi, C; Thaithong, S; Webster, HK; Yongvanitchit, K | 1 |
| Cook, CE; Elkins, PD; Hines, JW; Sparacino, CM | 1 |
| Boudreau, EF; Pavanand, K; Thosingha, L; Webster, HK | 1 |
| Coulanges, P; Coulaud, JP; Deloron, P; Le Bras, J | 1 |
| Bursey, JT; Hines, JW; Pellizzari, ED; Voyksner, RD | 1 |
| Boudreau, EF; Canfield, CJ; Cosgriff, TM; Desjardins, RE; Doberstyn, EB; Pamplin, CL | 1 |
| Cook, CE; Seltzman, TP; Tallent, CR; Wooten, JD | 1 |
| Fasanmade, AA; Jusko, WJ | 1 |
| De Pina, JJ; Fourcade, L; Hovette, P; Peyron, F; Rault, JP; Touze, JE | 1 |
| Chaulet, JF; Cheminel, V; Gaillard, Y; Prévosto, JM; Soares, O | 1 |
| Gibbs, ME; Ng, KT; Polya, GM; Sedman, GL; Wang, BH; Zhao, WQ | 1 |
| Bray, PG; Hawley, SR; Mungthin, M; Ward, SA | 1 |
| Forster, D; Kokwaro, G; Marsh, K; Mberu, EK; Murphy, SA; Mwangi, I; Newton, CJ; Watkins, WM; Winstanley, PA | 1 |
| Charman, WN; Currie, GJ; Humberstone, AJ; Porter, CJ; Scanlon, MJ | 1 |
| Kirch, W | 1 |
| Eichenlaub, D; Jelinek, T; Löscher, T; Schelbert, P | 1 |
| Nosten, F; Price, RN | 1 |
| Bernard, J; Bertherat, E; Keundjian, A; Soares, JL; Touze, JE | 1 |
| Betschart, B; Brandt, R; Cenni, B; Meyer, J | 1 |
| Sorabjee, JS | 1 |
| Fleckenstein, L; Keeratithakul, D; Loesuttiviboon, L; Ohrt, C; Schuster, B; Teja-Isavadharm, P; Watt, G; Webster, HK | 1 |
| Baird, JK; Basri, H; Fryauff, DJ; Hoffman, SL; Leksana, B; Masbar, S; McElroy, PD; Richie, TL; Subianto, B; Wignall, FS | 1 |
| Duong, TH; Igwangou, P; Kombila, M; Ngou-Milama, E; Ozouaki, P | 1 |
| Dolan, G; Edstein, MD; Keeratithakul, D; Nosten, F; Phaipun, L; Teja-Isavatharm, P; Ter Kuile, FO; Webster, HK; White, NJ | 1 |
| Polya, GM; Ternai, B; Wang, BH | 1 |
| Deharo, JC; Djiane, P; Fourcade, L; Imbert, P; Touze, JE; Van de Walle, JP | 1 |
| Wadhwa, S | 1 |
| Lazar, AI | 1 |
| Ager, A; Andersen, SL; Berman, J; Ellis, W; Kuschner, R; McGreevy, P; Ohrt, C; Rossan, R; Schuster, BG; Wesche, D | 1 |
| Bagade, AC; Bilolikar, HG; Gambhir, PS; Phadke, MA | 1 |
| Basco, LK; Le Bras, J; Makler, MM; Marquet, F | 1 |
| Fourcade, L; Mojon, M; Peyron, F; Touze, JE | 1 |
| Gras, C; Imbert, P; Martet, G; Morillon, M; Touze, JE | 1 |
| Blaschke, G; Terefe, H | 2 |
| Karbwang, J; Na Bangchang, K | 1 |
| Edwards, G; Ward, SA; Winstanley, PA | 1 |
| Baric, RS; Bright, P; Handy, J; Peel, SA; Yount, B | 1 |
| Aubry, AF; Basco, LK; Bouchaud, O; Farinotti, R; Gillotin, C; Gimenez, F; Le Bras, J; Wainer, IW | 1 |
| Hatton, P | 1 |
| Bouabdallah, K; Le Bras, M; Le Metayer, P; Longy-Boursier, M; Monlun, E; Neau, D; Receveur, MC | 1 |
| Mossop, RT | 1 |
| Bienzle, U; Graninger, W; Jenne, L; Kremsner, PG; Wildling, E | 2 |
| Kano, S; Masuda, G; Suzuki, M | 1 |
| Basco, L; Bouchaud, O; Charmot, G; Coulaud, JP; Khuong, MA; Lascaux, AS; Le Bras, J | 1 |
| Bakker, RB; Lampe, AS; Smith, SJ | 2 |
| Basco, LK; Bouchaud, O; Bouvet, E; Coulaud, JP; Farinotti, R; Genissel, B; Gillotin, C; Gimenez, F; Le Bras, J; Ramiliarisoa, O | 1 |
| Akhtar, T; Imran, M | 1 |
| Pohjola-Sintonen, S; Raatikka, M; Siikamäki, H; Toivonen, L; Viitasalo, M | 1 |
| Dolmans, WM; Leentvaar-Kuijpers, A; Stuiver, PC; van der Kaay, HJ; Warris-Versteegen, AA; Wetsteyn, JC | 1 |
| Bitsindou, P; Brasseur, P; Druilhe, P; Eggelte, TA; Moyou, RS; Penchenier, L; Samba, G | 1 |
| Hopperus Buma, AP; Kager, PA; Leentvaar-Kuijpers, A; Tendeloo, CH; van Gool, T; van Thiel, PP | 1 |
| Chongsuphajaisiddhi, T; Dolan, G; Edstein, MD; Luxemburger, C; Nosten, F; Phaipun, L; ter Kuile, FO; Webster, HK; White, NJ | 1 |
| Chongsuphajaisiddhi, T; Kyle, DE; Luxemburger, C; Nosten, F; ter Kuile, FO; White, NJ; Woodrow, C | 1 |
| Carme, B; Danis, M; Diquet, B; Gay, F; Hayette, MP | 1 |
| Basco, LK | 1 |
| Castot, A; Le Coz, P; Rapoport, P | 1 |
| Cochard, JF; Favarel Garrigues, JC; le Bras, M; Monlun, E; Pillet, O | 1 |
| Bienzle, U; Brandts, C; Graninger, W; Jenne, L; Kremsner, PG; Wernsdorfer, WH; Wildling, E; Winkler, S | 1 |
| Bunnag, D; Harinasuta, T; Karbwang, J; Laothavorn, P; Na Bangchang, K | 1 |
| Fleckenstein, L; Jongsakul, K; Karnasuta, C; Loesuttiviboon, L; Ohrt, CK; Schuster, B; Shanks, GD; Watt, G | 1 |
| Basco, LK; Le Bras, J; Ramiliarisoa, O | 1 |
| Gazin, PP | 1 |
| Bouabdallah, K; Favarel-Garrigues, JC; Gaston, R; Le Bras, M; Leenhardt, A; Longy-Boursier, M; Monlun, E; Pillet, O; Receveur, MC | 1 |
| Irimajiri, S; Kano, S; Matsuoka, Y; Obana, M; Oda, T; Suzuki, M | 1 |
| Bradley, DJ | 1 |
| Jagota, SC | 1 |
| Fadat, G; Le Bras, J; Louis, FJ; Louis, JP | 1 |
| Doorduijn, JK; Stuiver, PC; Wismans, PJ | 1 |
| Freese, JA; Gouws, E; Markus, MB; Rossouw, EJ; Sharp, BL | 1 |
| Edstein, MD; Kereu, RK; Rieckmann, KH; Shanks, GD; Spicer, PE | 1 |
| Howells, RE; Nateghpour, M; Ward, SA | 1 |
| Bhattacharyya, PC; Kakati, S; Saikia, PK; Sarma, PC | 1 |
| Kamalakar, KV; Rao, KS | 1 |
| Cowman, AF; Galatis, D; Thompson, JK | 1 |
| Bougouma, L; Del Nero, L; Lamizana, L; Nebie, I; Pietra, V; Sare, S | 1 |
| Kretschmer, H | 1 |
| Marsh, K; Watkins, WM; Woodrow, C | 1 |
| Bunnag, D; Chittamas, S; Harinasuta, T; Horton, J; Karbwang, J; Looareesuwan, S; Serville, P; Viravan, C | 1 |
| Carme, B | 1 |
| Go, ML; Lee, HS; Ngiam, TL | 1 |
| Kyle, DE; Martin, RK; Milhous, WK; Thaithong, S; Volkman, SK; Wilson, CM; Wirth, DF | 1 |
| Bock, HL; Braendli, B; Clemens, R; Fleischer, K; Kretschmer, H; Löscher, T; Markwalder, K; Nothdurft, HD; Schlunk, T; Weinke, T | 1 |
| Bock, HL; Clemens, R; Löscher, T; Nothdurft, HD | 1 |
| Horton, J | 2 |
| Baric, RS; Handy, J; Merritt, SC; Peel, SA | 1 |
| Gerena, L; Karle, JM; Milhous, WK; Olmeda, R | 1 |
| Parikh, PJ; Patel, HR; Patel, KH; Patel, RZ; Pathak, KJ; Shastri, H | 1 |
| Halliday, RC; Jones, BC; Kitteringham, NR; Park, BK; Smith, DA | 1 |
| Mharakurwa, S | 1 |
| Brocks, DR; Dennis, MJ; Schaefer, WH | 1 |
| Hayashi, A; Kanda, T; Kano, S; Suzuki, M | 1 |
| Bernard, J; Chaudet, H; Doury, JC; Imbert, P; Keundjian, A; Touze, JE; Viguier, A | 1 |
| Luby, SP; Matson, PA; Meriwether, RA; Redd, SC; Rolka, HR | 1 |
| Touze, JE | 1 |
| Basco, LK; de Pecoulas, PE; Le Bras, J; Wilson, CM | 1 |
| Angus, B; Bates, I; Krishna, S; Kyle, DE; Pipitaporn, B; Pukrittayakamee, S; Suputtamongkol, Y; Udomsangpetch, R; White, NJ | 1 |
| Atzori, C; Cargnel, A; Isabella, L; Orlando, G | 1 |
| Watkins, WM | 1 |
| Chunge, C; Luta, M; Mbori-Ngacha, DA; Muga, RO; Oloo, AJ; Onyango, FE | 1 |
| Bernard, J; Giudicelli, CP; Touze, JE | 1 |
| Anabwani, GM; Esamai, FO; Menya, DA | 1 |
| Charman, WN; Humberstone, AJ; Porter, CJ | 1 |
| Abecassis, L; Adam, MN; Baledent, F; Caillet, R; Giacomini, T; Le Bras, J; Poupin, F | 1 |
| Brault, M; Delling, U; Gros, P; Ruetz, S; Schurr, E | 1 |
| Ezedinachi, E | 1 |
| Nicolas, F; Nicolas, X | 1 |
| Barreiro Casal, G; Cilleruelo Ortega, MJ; García López, M; Martín Fontelos, P; Mellado Peña, MJ; Pérez Jurado, ML; Villota Arrieta, J | 1 |
| Brewer, TG; Leo, KU; Marino, MT; Wesche, DL | 1 |
| Charman, SA; Charman, WN; Porter, CJ | 1 |
| Charman, SA; Charman, WN; Humberstone, AJ; Porter, CJ | 1 |
| Gillespie, SH; Kennedy, N; Msaki, EP; Ngowi, FI; Ramsay, AR | 1 |
| Angel, G; Aulagnier, V; Diatta, B; Seck, M; Seignot, P | 1 |
| Bray, PG; Green, JE; Hawley, SR; Mungthin, M; Ritchie, GY; Ward, SA | 1 |
| Bernard, J; Doury, JC; Fourcade, L; Keundjian, A; Nicolas, X; Perret, JL; Soares, JM; Touze, JE | 1 |
| Botero, D; Boudreau, EF; Marquez, RE; Navaratnam, V; Restrepo, M | 1 |
| Karle, JM | 1 |
| Gorge, O; Nicolas, F; Nicolas, X; Perret, JL; Touze, JE | 1 |
| Baird, JK; Bangs, MJ; Basri, H; Fryauff, DJ; Harjosuwarno, S; Hoffman, SL; Richie, TL; Subianto, B; Tjitra, E; Wiady, I | 1 |
| Fleck, SL; Peters, W; Robinson, BL | 1 |
| Hartwell, LH; Sibley, CH; Vasquez, B; Wooden, JM | 1 |
| Chiwakata, CB; Dietrich, M; Egbring, R; Gaus, W; Hassemer, M; Hemmer, CJ; Hogel, J; Hort, G; Kern, P; Nawroth, PP; Seitz, R | 1 |
| De Pina, JJ; Fourcade, L; Gachot, B; Heno, P; Laurent, G; Touze, JE | 1 |
| Edwards, G; Gundersen, SG; Myrvang, B; Platou, ES; Rostrup, M; von der Lippe, E | 1 |
| Pillans, PI; Tish, KN | 1 |
| Batey, AJ; Coker, SJ; Edwards, G; Lambert, JP; Lightbown, ID | 1 |
| Falade, CO; Fehintola, FA; Kyle, DE; Makler, MT; Milhous, WK; Oduola, AM; Ogundahunsi, OA; Omitowoju, GO; Piper, RC; Schuster, BG; Sowunmi, A | 1 |
| Aideloje, SO; Onyeji, CO | 1 |
| Caliph, SM; Charman, WN; Porter, CJ | 2 |
| Charman, WN; Cowman, AF; Horton, J; Humberstone, AJ | 1 |
| Boele van Hensbroek, M; Kager, PA; Wetsteyn, JC; Zijlmans, CW | 1 |
| Doury, JC; Fusai, T; Pradines, B; Rogier, C; Tall, A; Trape, JF | 1 |
| Kremsner, PG; Philipps, J; Radloff, PD; Wernsdorfer, W | 1 |
| Coulibaly, SO; Dutheil, Y; Guiguemdé, TR; Ouédraogo, JB; Tall, F; Tinto, H; Traoré, B; Zampa, H | 1 |
| Deharo, JC; Fourcade, L; Heno, P; Peyron, F; Touze, JE | 1 |
| Charman, WN; Edwards, GA; Humberstone, AJ; Porter, CJ | 1 |
| Bangchang, KN; Farinotti, R; Gimenez, F; Gorichon, E; Karbwang, J; Martin, C; Thuillier, A | 1 |
| Clerinx, J; Colebunders, R; Coppens, G; Depraetere, K; Peetermans, WE; Schroyens, W; Van den Ende, J; Van den Enden, E; Van Gompel, A; Van Haegenborgh, T; Verstraeten, T | 1 |
| Graffin, B; Kraemer, P; Molinier, S; Perret, JL; Sane, M | 1 |
| Bray, PG; Mungthin, M; Ridley, RG; Ward, SA | 1 |
| Bilal, M; Yousaf, M | 1 |
| Baril, L; Bricaire, F; Caumes, E; Danis, M | 1 |
| Bhattacharjee, AK; Karle, JM | 1 |
| Deharo, E; Haemers, A; Ludwig, A; Mbela, TK | 1 |
| Doury, JC; Kombila, M; Lebeau, C; Mabika Mamfoumbi, M; Mourou Mbina, JR; Owono Medang, M; Parzy, D; Pradines, B | 2 |
| Aideloje, SO; Onyeji, CO; Ugwu, NC | 1 |
| Charman, WN; McIntosh, MP; Porter, CJ; Ramaswamy, M; Wasan, KM | 2 |
| Backmund, M; Eichenlaub, D; Hartmann, WJ; Hesse, J; von Zielonka, M | 1 |
| Bourgeade, A; Delmont, J | 1 |
| Burgel, PR; Camara, P; Hovette, P; Klotz, F; Mbaye, PS; Sane, M | 1 |
| Charman, WN; Edwards, GA; Khoo, SM; Porter, JH | 1 |
| Brocks, DR; Toni, JW | 1 |
| Le Bras, J | 1 |
| Baune, B; Farinotti, R; Furlan, V; Taburet, AM | 2 |
| Anabwani, G; Canfield, CJ; Hutchinson, DB | 1 |
| Baune, B; Becquemont, L; Farinotti, R; Flinois, JP; Furlan, V; Gimenez, F; Taburet, AM | 1 |
| Go, ML; Lim, LY | 2 |
| Chongsuphajaisiddhi, T; Luxemburger, C; Nosten, F; Phaipun, L; Price, R; Simpson, JA; ter Kuile, F; van Vugt, M; White, NJ | 1 |
| Barette, S; Bernard, J; Bouchaud, O; Danis, M; Delmont, J; Gathmann, I; Gras, C; Malvy, D; Mull, R; Touze, JE; van Agtmael, M | 1 |
| Bray, PG; Mungthin, M; Ward, SA | 1 |
| Lial, JP | 1 |
| Danis, M; Delhaes, L; Gay, F; Lazaro, JE; Thellier, M | 1 |
| Dumon, H; Garnier, JM; Lanza-Silhol, F; Minodier, P; Piarroux, R; Unal, D | 1 |
| Jacqz-Aigrain, E; Olivier, C; Rizk, C; Zhang, D | 1 |
| Basco, LK; Ringwald, P | 1 |
| Duraisingh, MT; Jones, P; Pinder, M; Sambou, I; von Seidlein, L; Warhurst, DC | 1 |
| Batey, AJ; Coker, SJ; Díaz, ME; Eisner, DA; Lightbown, ID | 1 |
| Caruana, SR; Cowman, AF; Kirk, K; Reed, MB; Saliba, KJ | 1 |
| Hombhanje, FW | 2 |
| Bulungol, P; Hombhanje, FW; Kereu, RK; Paika, R | 1 |
| Hombhanje, FW; Kereu, RK | 1 |
| Makonnen, E; Mengesha, T | 1 |
| Danis, M; Gay, F; Khusmith, S; Looareesuwan, S; Muanza, K; Supavej, S; Traoré, B; Viriyavejakul, P | 1 |
| Schuster, BG; Wang, WX; Wesche, DL; Woosley, RL | 1 |
| Brocks, DR; MacInnes, AI; Ramaswamy, M; Wasan, KM | 1 |
| Borrmann, S; Dangelmaier, O; Faucher, JF; Horton, J; Kremsner, PG; Lell, B; Missinou, MA | 1 |
| Lennard, MS; Sijumbil, G; Simooya, OO; Tucker, GT | 1 |
| Breit, SN; Bursill, JA; Campbell, TJ; Singleton, CB; Tie, H; Valenzuela, SM; Walker, BD; Wyse, KR | 1 |
| Puri, SK; Singh, N | 1 |
| Charman, WN; Khoo, SM; Porter, CJ | 1 |
| Emerole, GO; Farombi, EO; Olowu, BI | 1 |
| Coker, SJ; Edwards, G; Lambert, JP; Lightbown, ID | 1 |
| Adamu, A; Agbonlahor, DE; Dalyop, P; Elesha, SO; Fagbenro-Beyioku, AF; Ogunbanwo, JA | 1 |
| Aggarwal, P; Biswas, A; Handa, R; Suresh, V; Wali, JP; Wig, N | 1 |
| Holmström, S; Kontula, K; Piippo, K; Raatikka, M; Swan, H; Toivonen, L; Viitasalo, M | 1 |
| Abernethy, DR; Barbey, JT; Mohanty, S; Ohrt, C; Pezzullo, JC; Schuster, BG; Wesche, DL | 1 |
| Baird, JK; Doan, HN; Fryauff, DJ; Gómez-Saladín, E; Kain, KC; Le, DC; Nguyen, DT; Taylor, WR; Tran, TU | 1 |
| Lagardère, B; Laurent, C; Thibault, H | 1 |
| Granier, H; Klotz, F; Martin, J; Nicolas, X | 1 |
| Feng, SS; Go, ML | 1 |
| Bockarie, MJ; Gbakima, AA; Sahr, F; Willoughby, VR | 1 |
| Gendrel, D; Imbert, P; Lavallée, I; Marc, E; Moulin, F; Treluyer, JM | 1 |
| Chalermrut, K; Horton, J; Kaivipakbanyai, W; Krudsood, S; Kyle, D; Looareesuwan, S; Phophak, N; Silachamroon, U; Singhasivanon, P; Treeprasertsuk, S | 1 |
| Holm, R; Kristensen, HG; Müllertz, A; Pedersen, GP | 1 |
| Christensen, E; Holm, R; Høy, CE; Kristensen, HG; Müllertz, A | 1 |
| Charman, WN; Edwards, GA; Khoo, SM; Porter, CJ | 1 |
| Batey, AJ; Coker, SJ | 1 |
| Abdul-Fattah, AM; Bhargava, HN | 2 |
| Brocks, DR | 1 |
| Adoro, S; Farombi, EO; Uhunmwangho, S | 1 |
| Charman, WN; Edwards, GA; Khoo, SM; Porter, CJ; Prankerd, RJ | 1 |
| Adam, M; Bégué, P; Delée, S; Favier, R; Grimprel, E; Parez, N; Quinet, B | 1 |
| Betageri, GV; Yatvin, MB | 1 |
| Brocks, DR; Wasan, KM | 1 |
| Bindschedler, M; Degen, P; Lefèvre, G; Sioufi, A | 1 |
| Beytout, J; Caumon, L; Chouaki, M; Cueto, T; Delort, P; Dufraise, S; Monchard, F; Philippe, JM; Rimeize, H | 1 |
| January, CT; Mbai, M; Rajamani, S | 1 |
| Betageri, GV; Brocks, DR | 1 |
| Bedos, JP; Bruneel, F; Danis, M; Gachot, B; Regnier, B; Vachon, F; Wolff, M | 1 |
| Bohan, S; Buguet, A; Deharo, JC; Fourcade, L; Heno, P; Kouassi, E; Paule, P; Riviere, P; Thomas, G; Touze, JE | 1 |
| Charman, WN; Holm, R; Kristensen, HG; Müllertz, A; Porter, CJ | 1 |
| Alberti, C; Bédos, JP; Bruneel, F; Chevret, S; Durand, R; Hocqueloux, L; Le Bras, J; Régnier, B; Vachon, F; Wolff, M | 1 |
| Becquemont, L; Charbit, B; Funck-Brentano, C; Lepère, B; Peytavin, G | 1 |
| Atteke, C; Aubouy, A; Bakary, M; Deloron, P; Lébibi, J; Ndong, JM | 1 |
| Eckers, C; Thomson, LA; Wolff, JC | 1 |
| Angles, A; Bagheri, H; Magnaval, JF; Montastruc, JL | 1 |
| Go, ML; Li, QT | 1 |
| Jambou, R; Randrianarijaona, A; Randrianarivelojosia, M; Randrianasolo, L; Ratsimbasoa, A | 1 |
| Charman, WN; Porter, CJ; Shackleford, DM | 1 |
| Barratt, G; Bories, C; Legrand, P; Loiseau, P; Mosqueira, V | 1 |
| Nakajima, Y | 1 |
| Adjene, JO; Agoreyo, FO | 1 |
| Krishna, S; Kyle, D; Pukrittayakamee, S; Supanaranond, W; Teja-Isavadharm, P; ter Kuile, F; White, NJ | 1 |
| Charman, WN; Edwards, GA; Holm, R; Kristensen, HG; Müllertz, A; Porter, CJ | 1 |
| Charman, WN; Edwards, GA; Khoo, SM; Porter, CJ; Shackleford, DM | 1 |
| Charman, WN; Galland, A; Perry, CS; Prankerd, RJ; Taillardat-Bertschinger, A | 1 |
| Aberrane, S; Cohen, R; De la Rocque, F; Delacourt, C; Hau, I; Ovetchkine, P; Reinert, P; Seringe, S | 1 |
| Baird, JK; Doan, HN; Fryauff, DJ; Gómez-Saladín, E; Le, DC; Nguyen, DT; Susanti, I; Taylor, WR; Tran, TU | 1 |
| Batey, AJ; Charman, WN; Coker, SJ; McIntosh, MP; Porter, CJ | 1 |
| Campbell, M; Charman, WN; McIntosh, MP; Porter, CJ | 1 |
| Bégué, P; Grimprel, E; Parez, N; Pillon, V; Quinet, B | 1 |
| Boyd, BJ; Charman, WN; Kaukonen, AM; Porter, CJ | 2 |
| Hayton, K; Su, XZ | 1 |
| Barratt, G; Bories, C; Devissaguet, JP; Legrand, P; Loiseau, PM; Mosqueira, VC | 1 |
| Boyd, BJ; Charman, WN; Edwards, GA; Kaukonen, AM; O'Connor, JM; Porter, CJ; Taillardat-Bertschinger, A | 1 |
| Brown, ML; Geyer, JA; Terrell, JC; Trotta, RF | 1 |
| Bassi, PU; Onyeji, CO; Ukponmwan, OE | 1 |
| Bhattacharjee, AK; Dow, GS; Gerena, L; Hudson, TH; Koenig, ML; Lopez-Sanchez, M; Wolf, L | 1 |
| Beg, MA; Khan, MA; Razi, ST; Smego, RA | 1 |
| Adegoke, AO; Babalola, CP; Ogunjinmi, MA; Osimosu, MO | 1 |
| Holm, R; Karpf, DM; Kristensen, HG; Müllertz, A | 1 |
| Bray, PG; Fidock, DA; Johnson, DJ; Lakshmanan, V; Mungthin, M; Sidhu, AB; Ward, SA | 1 |
| Navarro-Polanco, RA; Sánchez-Chapula, JA; Sanguinetti, MC | 1 |
| Combes, JC; Garnier, JM; Minodier, P; Noël, G; Retornaz, K; Salles, M; Walters, H | 1 |
| Dumotier, B; Traebert, M | 1 |
| Brogård, M; Ljusberg-Wahren, H; Müllertz, A; Seier Nielsen, F; Troedsson, E | 1 |
| Fidock, DA; Sidhu, AB; Valderramos, SG | 1 |
| Charman, WN; Porter, CJ; Trevaskis, NL | 5 |
| Babalola, CP; Kolade, YT; Scriba, GK | 1 |
| Fidock, DA; Krishna, S; Sidhu, AB; Uhlemann, AC; Valderramos, JC; Valderramos, SG | 1 |
| Brocks, DR; El-Kadi, AO; Gharavi, N; Sattari, S; Shayeganpour, A | 1 |
| Ahmed, TM; Gilal, N; Isani, Z; Khan, MZ; Maqbool, S; Mehmood, K; Srinivasa, KB; Yazdani, I; Zafar, AB | 1 |
| Adegbolagun, OM; Bahalola, CP; Idowu, OS; Kolade, YT; Olaniyi, AA | 1 |
| Brockman, A; Chotivanich, K; Day, NP; Stepniewska, K; White, NJ | 1 |
| Barratt, G; Grabe-Guimarães, A; Guimarães, HN; Leite, EA; Machado-Coelho, GL; Mosqueira, VC | 1 |
| Falade, CO; Fehintola, FA; Sowunmi, A | 1 |
| Croft, AM | 1 |
| Daniyan, MO; Omoruyi, SI; Onyeji, CO | 1 |
| Abuaku, B; Duah, NO; Koram, KA; Quashie, NB | 1 |
| Black, J | 1 |
| Drake, AF; Goodwin, DJ; Holland, S; Lawrence, MJ; Leonard, G; Martini, L; Sepassi, S | 1 |
| Babalola, CP; Kolade, YT; Olaniyi, AA; Scriba, GK | 1 |
| Oladimeji, FA; Omoruyi, SI; Onyeji, CO | 1 |
| Adaramoye, OA; Ademowo, OG; Akinsanya, AM; Fafunso, MA; Nneji, CM; Osaimoje, DO | 1 |
| Egan, TJ; Hoppe, HC; Joiner, KA; Roberts, L | 1 |
| de Villiers, KA; Egan, TJ; Marques, HM | 1 |
| Holm, R; Jacobsen, J; Lind, ML; Müllertz, A | 1 |
| Brocks, DR; Fleischer, JG; Patel, JP; Wasan, KM | 1 |
| Jain, GK; Singh, SP | 1 |
| Brocks, DR; El-Kadi, AO; Korashy, HM; Patel, JP | 1 |
| Charman, WN; Edwards, GA; Faassen, WA; Nguyen, G; Porter, CJ; White, KL | 1 |
| Bouchaud, O; Danis, M; Dodoo, AN; Imbert, P; Legros, F; Touze, JE | 1 |
| Adedapo, A; Babalola, CP; Kolade, YT; Olaniyi, AA; Scriba, GK | 1 |
| Borrmann, S; Kiara, SM; Mwai, L; Nzila, A; Ochola, LI; Ohuma, E; Okombo, J; Pole, L; Rono, J | 1 |
| Ahmed, MR; Iskander, NM; Mohamed, AA; Youssef, TF | 1 |
| Brocks, DR; Patel, JP | 1 |
| Bisgaard, J; Holm, R; Jacobsen, J; Müllertz, A; Tønsberg, H | 1 |
| Abildrup, U; Alifrangis, LH; Alifrangis, M; Bygbjerg, IC; Hoegberg, L; Khalil, IF; Lemnge, MM; Maiga, D; Nyagonde, N; Persson, OP; Theander, TG; Vestergaard, LS | 1 |
| Kimura, M; Kinoshita, A; Kotaki, H; Yamada, H | 1 |
| Harborg, M; Holm, P; Holm, R; Jacobsen, J; Jørgensen, EB; Larsen, R; Müllertz, A | 1 |
| Assi, SB; Basco, LK; Bla, KB; Djaman, AJ; Koné, M; Mazabraud, A; Yavo, W | 1 |
| Angelino, E; Barnes, KG; Becker, JS; Birren, BW; Cortese, JF; Daniels, RF; Eskin, E; Furlotte, NA; Grossman, SR; Happi, C; Hartl, DL; Johnson, CA; Kang, HM; Karlsson, EK; Lander, ES; Lukens, AK; Mboup, S; Milner, DA; Ndiaye, D; Neafsey, DE; Park, DJ; Rosen, DM; Sabeti, PC; Sarr, O; Schaffner, SF; Shlyakhter, I; Van Tyne, D; Volkman, SK; Wiegand, RC; Wirth, DF; Yamins, D | 1 |
| Boll, JB; Holm, R; Jacobsen, J; Mu, H; Müllertz, A; Tønsberg, H | 1 |
| Adewunmi, CO; Agbedahunsi, JM; Ijarotimi, SO; Onyeji, CO | 1 |
| Attama, AA; Igbonekwu, CN | 1 |
| Berger, F; Bertani, S; Bouchier, C; Ekala, MT; Legrand, E; Mercereau-Puijalon, O; Meynard, JB; Musset, L; Péneau, J; Volney, B; Yrinesi, J | 1 |
| Holm, R; Müllertz, A; Rades, T; Thomas, N | 1 |
| Abedinpour, P; Farsad, S; Holm, R; Jørgensen, EB; Müllertz, A; Tønsberg, H | 1 |
| Blazier, AS; Chavali, AK; Jensen, PA; Papin, JA; Pearson, RD; Tlaxca, JL | 1 |
| Al-Farsi, HM; Al-Hashami, ZS; Al-Qahtani, A; Al-Sheikh, AA; Babiker, HA; Bin Dajem, SM | 1 |
| Brocks, DR; El-Kadi, AO; Hamdy, DA; Patel, JP | 1 |
| Caliph, SM; Charman, WN; Porter, CJ; Trevaskis, NL | 1 |
| Hesselkilde, JZ; Holm, R; Jørgensen, EB; Müllertz, A | 1 |
| Bae, TJ; Jang, Y; Kim, BC; Kim, DG; Kim, JT; Kim, S; Lee, JH; Lee, JJ; Park, KM; Rho, K | 1 |
| Bouchy-Bagros, ML; Denjoy, I; Lupoglazoff, JM; Pull, L; Siriez, JY | 1 |
| Aarons, L; Edstein, MD; Klein, K; Nosten, F; Teja-Isavadharm, P; Ter Kuile, FO; White, NJ | 1 |
| Caliph, SM; Charman, WN; Nguyen, G; Porter, CJ; Trevaskis, NL; Tso, P | 1 |
| Cowman, AF; Healer, J; Uboldi, AD; Van Tyne, D; Wirth, DF | 1 |
| Bulitta, JB; Caliph, SM; Cao, E; Han, S; Hu, L; Porter, CJ; Trevaskis, NL | 1 |
| Porter, CJ; Trevaskis, NL; Yeap, YY | 1 |
| Abdel-Aal Sabra, AN; El-Lakkany, NM; Hammam, OA; Seif El-Din, SH | 1 |
| Clark, J; Golenser, J; Guiguemde, WA; Guo, J; Guy, RK; Haynes, RK; Hunt, NH; Marciano, A | 1 |
| Gayen, JR; Raju, KS; Siddiqui, HH; Singh, SK; Singh, SP; Taneja, I; Wahajuddin, M | 1 |
| Michaelsen, MH; Müllertz, A; Rades, T; Sivak, O; Wasan, KM | 1 |
| Raju, KS; Singh, SP; Taneja, I; Wahajuddin, M | 1 |
| Bøtker, J; Markl, D; Michaelsen, MH; Müllertz, A; Rades, T; Rantanen, J; Rasch, C; Zeitler, JA | 1 |
| Holm, R; Larsen, AT; Müllertz, A | 1 |
| Bowater, IC; Charman, WN; Eldridge, DS; Haidar, I; Harding, IH | 1 |
| Boyd, BJ; Clulow, AJ; Hawley, A; Pham, AC; Ramirez, G; Salim, M | 1 |
| Bowater, IC; Haidar, I; Harding, IH; McDowall, AW | 1 |
| Amalvict, R; Benoit, N; Chevalier, A; Delaunay, P; Fonta, I; Jeandel, PY; Madamet, M; Marty, P; Massamba, L; Mondain, V; Mosnier, J; Pomares, C; Pradines, B | 1 |
| Be Rziņš, KR; Beilles, S; Boyd, BJ; Clulow, AJ; Fraser-Miller, SJ; Gordon, KC; Hawley, A; Ramirez, G; Salim, M; Sutton, JJ | 1 |
| Chen, Y; Chiang, PC; Dolton, MJ | 1 |
| Adnan, M; Ashraf, SA; Badraoui, R; Bhardwaj, J; Goyal, M; Hamadou, WS; Jahan, S; Jamal, A; Sachidanandan, M; Sharma, P; Siddiqui, AJ; Snoussi, M | 1 |
21 review(s) available for halofantrine and phenanthrenes
| Article | Year |
|---|---|
Halofantrine. A review of its antimalarial activity, pharmacokinetic properties and therapeutic potential.
Topics: Animals; Antimalarials; Humans; Phenanthrenes | 1992 |
Halofantrine in the treatment of malaria.
Topics: Administration, Oral; Animals; Antimalarials; Drug Administration Schedule; Drug Evaluation; Half-Life; Humans; Malaria; Phenanthrenes; Plasmodium falciparum | 1989 |
Hemodynamic effects of extracardiac drugs.
Topics: Antidepressive Agents; Antimalarials; Cardiovascular System; Dose-Response Relationship, Drug; Hemodynamics; Histamine Antagonists; Humans; Phenanthrenes; Probucol | 1995 |
New antimalarials. A risk-benefit analysis.
Topics: Animals; Antimalarials; Artemisinins; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pregnancy; Risk Assessment; Sesquiterpenes | 1995 |
[Halofantrine: for new rules of prescription].
Topics: Antimalarials; Drug Prescriptions; Heart; Heart Diseases; Hemolysis; Humans; Phenanthrenes | 1995 |
Clinical pharmacokinetics of halofantrine.
Topics: Animals; Antimalarials; Dogs; Drug Interactions; Humans; Malaria, Falciparum; Mice; Phenanthrenes; Rats | 1994 |
Clinical pharmacokinetics in the treatment of tropical diseases. Some applications and limitations.
Topics: Chloroquine; Diethylcarbamazine; Drug Resistance; Echinococcosis; Filariasis; Humans; Malaria; Mefloquine; Pharmacokinetics; Phenanthrenes; Pyrimethamine; Quinine; Sulfadoxine; Tropical Medicine | 1994 |
Halofantrine: a new substance for treatment of multidrug-resistant malaria.
Topics: Acute Disease; Adult; Animals; Antimalarials; Child, Preschool; Drug Evaluation; Humans; Incidence; Infant; Malaria; Malaria, Falciparum; Malaria, Vivax; Phenanthrenes; Plasmodium falciparum; Prospective Studies; Travel | 1993 |
[Correct usage of amino alcohols].
Topics: Antimalarials; Clinical Protocols; Drug Administration Schedule; Drug Resistance; Humans; Malaria; Mefloquine; Phenanthrenes; Quinine | 1995 |
Pharmacology and pharmacokinetics of new antimalarials.
Topics: Africa; Antimalarials; Artemether; Artemisinins; Drug Costs; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Sesquiterpenes; Trimethoprim, Sulfamethoxazole Drug Combination | 1995 |
[The treatment of malaria].
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Phenanthrenes; Pregnancy; Primaquine | 1997 |
Is halofantrine still advisable in malaria attacks?
Topics: Antimalarials; Electrocardiography; Heart Diseases; Hemolysis; Humans; Malaria, Falciparum; Phenanthrenes; Prospective Studies | 1997 |
Comparative efficacy and safety of chloroquine and alternative antimalarial drugs: a meta-analysis from six African countries.
Topics: Africa, Eastern; Africa, Western; Amodiaquine; Antimalarials; Chloroquine; Drug Combinations; Drug Costs; Humans; Malaria; Mefloquine; Patient Selection; Phenanthrenes; Pyrimethamine; Quinine; Safety; Sulfadoxine; Treatment Outcome | 1999 |
Mechanism of cardiotoxicity of halofantrine.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Animals; Antimalarials; Cardiovascular Diseases; Cats; Child; Child, Preschool; Disease Models, Animal; Female; Heart Conduction System; Humans; Infant; Male; Middle Aged; Myocardium; Phenanthrenes | 2000 |
[Epidemiological and therapeutic aspects of plasmodial infection from Plasmodium vivax].
Topics: Antimalarials; Chloroquine; Clinical Protocols; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Malaria, Vivax; Phenanthrenes; Primaquine; Recurrence; Risk Factors; Treatment Outcome | 2000 |
[Antiprotozoal drugs].
Topics: Animals; Antiprotozoal Agents; Drug Combinations; Emetine; Humans; Mefloquine; Metronidazole; Phenanthrenes; Primaquine; Protozoan Infections; Pyrimethamine; Quinine; Sulfadoxine; Tinidazole | 2003 |
Genetic and biochemical aspects of drug resistance in malaria parasites.
Topics: Animals; Antimalarials; Chloroquine; Dihydropteroate Synthase; Drug Resistance; Drug Resistance, Multiple; Humans; Linkage Disequilibrium; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Membrane Proteins; Membrane Transport Proteins; Mutation; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax; Protozoan Proteins; Pyrimethamine; Sulfadoxine; Tetrahydrofolate Dehydrogenase | 2004 |
Emerging drug--resistance and guidelines for treatment of malaria.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance, Multiple; Drug Therapy, Combination; Follow-Up Studies; Humans; Malaria, Falciparum; Pakistan; Phenanthrenes; Plasmodium falciparum; Quinidine; Quinine; Sesquiterpenes; Time Factors | 2004 |
Antimalarial drugs: QT prolongation and cardiac arrhythmias.
Topics: Amodiaquine; Drug Approval; Electrophysiology; Humans; Long QT Syndrome; Malaria; Phenanthrenes; Risk Assessment; Risk Factors; Torsades de Pointes | 2005 |
A lesson learnt: the rise and fall of Lariam and Halfan.
Topics: Antimalarials; Drug Industry; Financing, Government; Forecasting; Humans; Interprofessional Relations; Malaria; Mefloquine; Mental Disorders; Military Personnel; Phenanthrenes; Technology, Pharmaceutical; United States; United States Food and Drug Administration | 2007 |
Fatal cardiotoxicity related to halofantrine: a review based on a worldwide safety data base.
Topics: Antimalarials; Arrhythmias, Cardiac; Humans; Phenanthrenes | 2009 |
60 trial(s) available for halofantrine and phenanthrenes
| Article | Year |
|---|---|
[Efficacy of radical treatment with halofantrine on the prevention of imported Plasmodium falciparum malaria].
Topics: Adult; Antimalarials; Chloroquine; Humans; Malaria, Falciparum; Male; Military Personnel; Phenanthrenes | 1992 |
Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand.
Topics: Administration, Oral; Adult; Antimalarials; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Thailand; Treatment Outcome | 1992 |
Efficacy, safety and acceptability of halofantrine in the treatment of acute Plasmodium falciparum malaria in African children (Gabon).
Topics: Acute Disease; Adolescent; Antimalarials; Child; Child, Preschool; Drug Administration Schedule; Female; Gabon; Humans; Infant; Malaria, Falciparum; Male; Phenanthrenes | 1992 |
The efficacy of halofantrine in the treatment of acute malaria in nonimmune travelers.
Topics: Acute Disease; Adult; Antimalarials; Drug Resistance; Drug Tolerance; Female; Follow-Up Studies; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Male; Middle Aged; Phenanthrenes; Travel | 1992 |
[Trial of halofantrine in the treatment of malaria attacks by Plasmodium falciparum in Dakar (Senegal)].
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Child; Child, Preschool; Drug Tolerance; Humans; Malaria, Falciparum; Middle Aged; Phenanthrenes; Senegal | 1991 |
Halofantrine in the treatment of acute uncomplicated falciparum malaria in the Philippines.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Blood Cell Count; Blood Chemical Analysis; Drug Resistance; Hematocrit; Hemoglobins; Humans; Malaria, Falciparum; Parasite Egg Count; Phenanthrenes | 1991 |
Halofantrine-induced pruritus amongst subjects who itch to chloroquine.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Chloroquine; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Kinetics; Malaria; Male; Middle Aged; Pain Measurement; Phenanthrenes; Pruritus | 1991 |
Pruritus and antimalarial drugs in Africans.
Topics: Antimalarials; Chloroquine; Humans; Nigeria; Phenanthrenes; Pruritus | 1989 |
Halofantrine.
Topics: Antimalarials; Clinical Trials as Topic; Humans; Kenya; Phenanthrenes | 1989 |
Pharmacokinetics of halofantrine in man: effects of food and dose size.
Topics: Adult; Antimalarials; Fasting; Food; Half-Life; Humans; Male; Phenanthrenes | 1989 |
Efficacy of multiple-dose halofantrine in treatment of chloroquine-resistant falciparum malaria in children in Kenya.
Topics: Administration, Oral; Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Resistance; Female; Follow-Up Studies; Half-Life; Humans; Infant; Kenya; Malaria; Male; Phenanthrenes; Plasmodium falciparum; Time Factors | 1988 |
Clinical trials with halofantrine hydrochloride in Malawi.
Topics: Administration, Oral; Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Female; Follow-Up Studies; Humans; Infant; Malaria; Malawi; Male; Phenanthrenes; Plasmodium falciparum; Recurrence; Time Factors | 1988 |
Malaria: treatment efficacy of halofantrine (WR 171,669) in initial field trials in Thailand.
Topics: Adult; Antimalarials; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Humans; Malaria; Male; Mefloquine; Middle Aged; Phenanthrenes; Quinolines; Random Allocation | 1988 |
Halofantrine pharmacokinetics in Kenyan children with non-severe and severe malaria.
Topics: Administration, Oral; Antimalarials; Biological Availability; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infant; Kenya; Malaria, Falciparum; Male; Phenanthrenes; Tissue Distribution | 1995 |
Pharmacokinetics of an extended-dose halofantrine regimen in patients with malaria and in healthy volunteers.
Topics: Administration, Oral; Adult; Antimalarials; Biological Availability; Chromatography, High Pressure Liquid; Drug Administration Schedule; Half-Life; Humans; Malaria, Falciparum; Male; Phenanthrenes | 1995 |
Treatment of chloroquine-resistant Plasmodium vivax with chloroquine and primaquine or halofantrine.
Topics: Adolescent; Animals; Child; Chloroquine; Drug Administration Schedule; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria, Vivax; Male; Middle Aged; Phenanthrenes; Plasmodium vivax; Primaquine | 1995 |
Comparison of capillary whole blood, venous whole blood, and plasma concentrations of mefloquine, halofantrine, and desbutyl-halofantrine measured by high-performance liquid chromatography.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Linear Models; Malaria, Falciparum; Mefloquine; Middle Aged; Phenanthrenes; Reproducibility of Results | 1994 |
Efficacy of halofantrine in malaria.
Topics: Antimalarials; Child; Child, Preschool; Female; Humans; Infant; Malaria; Male; Phenanthrenes | 1994 |
Comparison of micronized halofantrine with chloroquine-antibiotic combinations for treating Plasmodium falciparum malaria in adults from Gabon.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antimalarials; Chloroquine; Clindamycin; Doxycycline; Drug Therapy, Combination; Female; Follow-Up Studies; Gabon; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes | 1994 |
High dose chloroquine versus micronized halofantrine in chloroquine-resistant Plasmodium falciparum malaria.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Phenanthrenes | 1994 |
Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Drug Resistance; Female; Follow-Up Studies; Humans; Infant; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Myanmar; Phenanthrenes; Plasmodium falciparum; Prospective Studies; Recurrence; Refugees; Thailand; Treatment Failure | 1993 |
Cardiac effects of antimalarial treatment with halofantrine.
Topics: Adolescent; Adult; Antimalarials; Electrocardiography; Female; Heart; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Prospective Studies | 1993 |
Halofantrine sensitivity.
Topics: Animals; Antimalarials; Child; Drug Resistance; Gabon; Humans; Malaria, Falciparum; Phenanthrenes; Plasmodium falciparum | 1993 |
Efficacy and tolerance of extended-dose halofantrine for drug-resistant falciparum malaria in Thailand.
Topics: Adult; Animals; Chi-Square Distribution; Diarrhea; Dizziness; Drug Resistance; Drug Therapy, Combination; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Tetracycline; Thailand; Vomiting | 1994 |
Halofantrine in the treatment of acute malaria: a multi-centre study in 268 patients.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Antimalarials; Body Weight; Child; Child, Preschool; Female; Fever; Humans; Infant; Malaria, Falciparum; Malaria, Vivax; Male; Middle Aged; Phenanthrenes; Recurrence; Time Factors; Treatment Outcome | 1993 |
Postexposure administration of halofantrine for the prevention of malaria.
Topics: Administration, Oral; Adult; Antimalarials; Chloroquine; Drug Administration Schedule; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Papua New Guinea; Phenanthrenes; Travel | 1993 |
In vivo sensitivity of Plasmodium falciparum to halofantrine hydrochloride in Burkina Faso.
Topics: Alanine Transaminase; Animals; Antimalarials; Aspartate Aminotransferases; Bilirubin; Burkina Faso; Child; Child, Preschool; Chloroquine; Creatinine; Drug Resistance; Female; Follow-Up Studies; Hematocrit; Hemoglobins; Humans; Leukocyte Count; Malaria, Falciparum; Male; Phenanthrenes; Plasmodium falciparum | 1994 |
Clinical trials with halofantrine in acute uncomplicated falciparum malaria in Thailand.
Topics: Adolescent; Adult; Antimalarials; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Phenanthrenes; Thailand | 1993 |
[Halofantrine in the treatment of imported malaria in nonimmune travelers].
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Drug Therapy, Combination; Drug Tolerance; Female; Germany; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Male; Middle Aged; Phenanthrenes; Plasmodium malariae; Primaquine; Prospective Studies; Recurrence; Switzerland; Time Factors; Travel | 1993 |
Halofantrine: a new substance for treatment of multidrug-resistant malaria.
Topics: Acute Disease; Adult; Animals; Antimalarials; Child, Preschool; Drug Evaluation; Humans; Incidence; Infant; Malaria; Malaria, Falciparum; Malaria, Vivax; Phenanthrenes; Plasmodium falciparum; Prospective Studies; Travel | 1993 |
Efficacy of halofantrine in the treatment of uncomplicated falciparum malaria.
Topics: Adolescent; Adult; Antimalarials; Child; Child, Preschool; Double-Blind Method; Drug Combinations; Drug Resistance; Female; Humans; Infant; Malaria, Falciparum; Male; Phenanthrenes; Pyrimethamine; Sulfalene; Survival Analysis; Time Factors; Treatment Outcome | 1995 |
A randomised controlled trial to assess the relative efficacy of chloroquine, amodiaquine, halofantrine and Fansidar in the treatment of uncomplicated malaria in children.
Topics: Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Follow-Up Studies; Humans; Malaria, Falciparum; Male; Phenanthrenes; Pyrimethamine; Sulfadoxine; Treatment Outcome | 1996 |
In vivo efficacy of chloroquine, halofantrine, pyrimethamine-sulfadoxine and qinghaosu (artesunate) in the treatment of malaria in Calabar, Nigeria.
Topics: Adolescent; Antimalarials; Artemisinins; Artesunate; Child; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Nigeria; Phenanthrenes; Pyrimethamine; Sesquiterpenes; Sulfadoxine; Time Factors; Urban Health | 1996 |
[Monitoring of long QT interval during treatment of malaria with halofantrine].
Topics: Adolescent; Adult; Antimalarials; Drug Monitoring; Electrocardiography; Humans; Long QT Syndrome; Malaria; Male; Phenanthrenes; Prospective Studies | 1995 |
Efficacy of low-dose halofantrine for second treatment of uncomplicated falciparum malaria.
Topics: Adult; Animals; Antimalarials; Drug Administration Schedule; France; Gabon; Humans; Malaria, Falciparum; Male; Military Personnel; Phenanthrenes; Plasmodium falciparum | 1997 |
A clinical trial with halofantrine on patients with falciparum malaria in Colombia.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Colombia; Double-Blind Method; Drug Administration Schedule; Heart; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Recurrence | 1996 |
Halofantrine and primaquine for radical cure of malaria in Irian Jaya, Indonesia.
Topics: Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Follow-Up Studies; Humans; Indonesia; Malaria, Falciparum; Malaria, Vivax; Male; Parasitemia; Phenanthrenes; Primaquine; Recurrence; Treatment Outcome | 1997 |
Supportive pentoxifylline in falciparum malaria: no effect on tumor necrosis factor alpha levels or clinical outcome: a prospective, randomized, placebo-controlled study.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Antimalarials; Biopterins; Drug Therapy, Combination; Female; Humans; L-Lactate Dehydrogenase; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Neopterin; Parasitemia; Pentoxifylline; Phenanthrenes; Phosphodiesterase Inhibitors; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Tumor Necrosis Factor-alpha | 1997 |
Metabolism of halofantrine to its equipotent metabolite, desbutylhalofantrine, is decreased when orally administered with ketoconazole.
Topics: Administration, Oral; Animals; Antimalarials; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Ketoconazole; Male; Mixed Function Oxygenases; Phenanthrenes | 1998 |
Combination atovaquone and proguanil hydrochloride vs. halofantrine for treatment of acute Plasmodium falciparum malaria in children.
Topics: Acute Disease; Animals; Antimalarials; Atovaquone; Child; Child, Preschool; Drug Therapy, Combination; Feces; Female; Humans; Malaria, Falciparum; Male; Naphthoquinones; Phenanthrenes; Plasmodium falciparum; Proguanil; Treatment Outcome | 1999 |
The comparative efficacy and tolerability of CGP 56697 (artemether + lumefantrine) versus halofantrine in the treatment of uncomplicated falciparum malaria in travellers returning from the Tropics to The Netherlands and France.
Topics: Adolescent; Adult; Africa; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Double-Blind Method; Drug Combinations; Ethanolamines; Female; Fluorenes; France; Humans; Malaria, Falciparum; Male; Middle Aged; Netherlands; Parasite Egg Count; Phenanthrenes; Plasmodium falciparum; Sesquiterpenes; Time Factors; Travel; Tropical Climate | 1999 |
Molecular epidemiology of malaria in Yaounde, Cameroon V. analysis of the omega repetitive region of the plasmodium falciparum CG2 gene and chloroquine resistance.
Topics: Adolescent; Adult; Animals; Antimalarials; Cameroon; Child; Chloroquine; DNA Primers; DNA, Protozoan; Drug Resistance; Electrophoresis, Agar Gel; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Naphthyridines; Parasitemia; Phenanthrenes; Plasmodium falciparum; Polymerase Chain Reaction; Regression Analysis; Repetitive Sequences, Nucleic Acid; Scintillation Counting; Sequence Analysis, DNA | 1999 |
Effect of a single oral dose of Fansidar on the pharmacokinetics of halofantrine in healthy volunteers: a preliminary report.
Topics: Adult; Antimalarials; Cross-Over Studies; Drug Combinations; Drug Interactions; Humans; Male; Phenanthrenes; Pyrimethamine; Sulfadoxine | 2000 |
Halofantrine in the treatment of uncomplicated falciparum malaria with a three-dose regimen in Papua New Guinea: a preliminary report.
Topics: Adolescent; Adult; Antimalarials; Electrocardiography; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes | 1998 |
Malaria chemoprophylaxis with tafenoquine: a randomised study.
Topics: Adolescent; Adult; Aminoquinolines; Antimalarials; Child; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Gabon; Humans; Malaria, Falciparum; Male; Phenanthrenes | 2000 |
Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians.
Topics: Administration, Oral; Adult; Antimalarials; Black People; Chloroquine; Chromatography, Gas; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Debrisoquin; Humans; Liver; Male; Phenanthrenes; Zambia | 1998 |
Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation.
Topics: Adult; Antimalarials; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Metabolic Clearance Rate; Molecular Conformation; Phenanthrenes | 2001 |
Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in southern, central Vietnam using an extended 28-day in vivo test and polymerase chain reaction genotyping.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Genotype; Humans; Malaria, Vivax; Male; Merozoite Surface Protein 1; Middle Aged; Phenanthrenes; Plasmodium vivax; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Vietnam | 2000 |
[Halofantrine in pediatrics: survey in Ile-de-France].
Topics: Antimalarials; Child; France; Humans; Malaria; Phenanthrenes | 2001 |
Clinical trial of halofantrine with modified doses for treatment of malaria in the hospital for tropical diseases.
Topics: Adolescent; Adult; Antimalarials; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Thailand | 2001 |
Comparison of the cardiac effects of the antimalarials co-artemether and halofantrine in healthy participants.
Topics: Administration, Oral; Adult; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Cross-Over Studies; Double-Blind Method; Drug Combinations; Electrocardiography; Ethanolamines; Fluorenes; Heart; Heart Rate; Humans; Long QT Syndrome; Male; Phenanthrenes; Sesquiterpenes | 2002 |
The effects of antimalarial drugs on ventricular repolarization.
Topics: Adult; Antimalarials; Electrocardiography; Female; Heart Rate; Heart Ventricles; Humans; Malaria, Falciparum; Male; Phenanthrenes; Prospective Studies | 2002 |
Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine.
Topics: Adult; Area Under Curve; Beverages; Citrus; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Female; Food-Drug Interactions; Humans; Male; Phenanthrenes | 2002 |
Effects of tetracycline on the pharmacokinetics of halofantrine in healthy volunteers.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Antimalarials; Area Under Curve; Cross-Over Studies; Half-Life; Humans; Male; Phenanthrenes; Tetracycline | 2004 |
[Mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria].
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Female; Humans; Infant; Long QT Syndrome; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Treatment Outcome | 2005 |
Efficacy and safety of halofantrine in Pakistani children and adults with malaria caused by P. falciparum and P. vivax.
Topics: Adolescent; Adult; Blood Cell Count; Blood Chemical Analysis; Child; Child, Preschool; Electrocardiography; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Pakistan; Parasitemia; Phenanthrenes; Treatment Outcome | 2006 |
Effects of prior administration of amodiaquine on the disposition of halofantrine in healthy volunteers.
Topics: Adult; Amodiaquine; Antimalarials; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Interactions; Electrocardiography; Half-Life; Humans; Male; Metabolic Clearance Rate; Phenanthrenes | 2007 |
Effect of kolanut on the pharmacokinetics of the antimalarial drug halofantrine.
Topics: Administration, Oral; Adult; Antimalarials; Area Under Curve; Caffeine; Chromatography, High Pressure Liquid; Cola; Cross-Over Studies; Drug Interactions; Half-Life; Humans; Male; Nuts; Phenanthrenes | 2008 |
Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers.
Topics: Adult; Antifungal Agents; Antimalarials; Cross-Over Studies; Drug Interactions; Fluconazole; Humans; Male; Phenanthrenes | 2009 |
Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria.
Topics: Adolescent; Adult; Antimalarials; Bayes Theorem; Biological Availability; Body Weight; Case-Control Studies; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Humans; Infant; Likelihood Functions; Malaria, Falciparum; Male; Middle Aged; Models, Biological; Myanmar; Nonlinear Dynamics; Phenanthrenes; Thailand; Tissue Distribution; Young Adult | 2012 |
330 other study(ies) available for halofantrine and phenanthrenes
| Article | Year |
|---|---|
[Treatment of malaria in children in France].
Topics: Antimalarials; Child; Chloroquine; France; Humans; Malaria, Cerebral; Malaria, Falciparum; Mefloquine; Phenanthrenes; Quinine | 1992 |
The treatment of falciparum malaria in children with halofantrine suspension.
Topics: Acute Disease; Adolescent; Antimalarials; Child; Child, Preschool; Drug Evaluation; Female; Follow-Up Studies; Humans; Infant; Malaria, Falciparum; Malaria, Vivax; Male; Patient Acceptance of Health Care; Phenanthrenes; Recurrence; Safety; Suspensions; Treatment Outcome | 1992 |
Halofantrine and acute intravascular haemolysis.
Topics: Acute Disease; Adolescent; Animals; Antimalarials; Blackwater Fever; Blood; Central African Republic; Hemolysis; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Plasmodium falciparum; Renal Dialysis | 1992 |
[Malaria prophylaxis].
Topics: Animals; Antimalarials; Culicidae; Humans; Insect Bites and Stings; Malaria; Phenanthrenes | 1992 |
Plasmodium falciparum: effect of chloroquine, halofantrine and pyrimethamine on the infectivity of gametocytes for Anopheles stephensi mosquitoes.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Insect Vectors; Phenanthrenes; Plasmodium falciparum; Pyrimethamine | 1992 |
Measurement of halofantrine and its major metabolite desbutylhalofantrine in plasma and blood by high-performance liquid chromatography: a new methodology.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Humans; Male; Phenanthrenes; Reference Values; Reproducibility of Results | 1992 |
In vitro activity of halofantrine and its relationship to other standard antimalarial drugs against African isolates and clones of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Phenanthrenes; Plasmodium falciparum | 1992 |
A new model for testing gametocytocidal effects of some antimalarial drugs on Plasmodium falciparum in vitro.
Topics: Animals; Anopheles; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; In Vitro Techniques; Models, Biological; Phenanthrenes; Plasmodium falciparum; Pyrimethamine; Quinine | 1992 |
Identification of metabolites of halofantrine, a new candidate anti-malarial drug, by gas chromatography-mass spectrometry.
Topics: Animals; Antimalarials; Chromatography, Thin Layer; Dogs; Gas Chromatography-Mass Spectrometry; Male; Phenanthrenes | 1992 |
[Parasitemia in Plasmodium falciparum malarial attacks in children].
Topics: Adolescent; Antimalarials; Carrier State; Child; Child, Preschool; Gabon; Humans; Malaria, Falciparum; Phenanthrenes; Quinine; Seizures, Febrile | 1992 |
Proposals for a new therapeutic strategy for simple Plasmodium falciparum malaria attacks in Cameroon.
Topics: Administration, Oral; Aminoquinolines; Amodiaquine; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine | 1992 |
Mefloquine-halofantrine cross-resistance in Plasmodium falciparum induced by intermittent mefloquine pressure.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine | 1992 |
In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum.
Topics: Animals; Antimalarials; Dose-Response Relationship, Drug; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Stereoisomerism | 1992 |
[Halofantrine overdosage].
Topics: Antimalarials; Drug Overdose; Humans; Iatrogenic Disease; Male; Middle Aged; Phenanthrenes | 1992 |
Gametocytocidal and sporontocidal activity of antimalarials against Plasmodium berghei ANKA in ICR Mice and Anopheles stephensi mosquitoes.
Topics: Acridines; Aminoquinolines; Analysis of Variance; Animals; Anopheles; Antimalarials; Female; Germ Cells; Guanidines; Imidazoles; Mice; Mice, Inbred ICR; Naphthoquinones; Phenanthrenes; Plasmodium berghei; Primaquine | 1992 |
Emergence of multidrug-resistant Plasmodium falciparum in Thailand: in vitro tracking.
Topics: Animals; Antimalarials; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Regression Analysis; Thailand | 1992 |
Susceptibility of Plasmodium falciparum strains to mefloquine in an urban area in Senegal.
Topics: Adolescent; Adult; Aminoquinolines; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; In Vitro Techniques; Infant; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum | 1992 |
Type RI resistance to halofantrine in West Africa.
Topics: Animals; Antimalarials; Biological Availability; Chloroquine; Cote d'Ivoire; Drug Resistance; Follow-Up Studies; France; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Recurrence; Travel | 1991 |
Malaria vaccines in the future--what strategies now?
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Forecasting; Humans; Malaria; Mosquito Control; Phenanthrenes; Plasmodium; Protozoan Vaccines | 1991 |
Pharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Drug Administration Schedule; Humans; Malaria, Falciparum; Melanesia; Phenanthrenes | 1991 |
[Malaria in the republic of São Tomé and Principe. Epidemiologic evaluation and chemoresistance of P. falciparum].
Topics: Age Factors; Animals; Antimalarials; Atlantic Islands; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Seasons; Sex Factors; Splenomegaly | 1991 |
Drug use and design in the nineties.
Topics: Aminoquinolines; Amodiaquine; Antimalarials; Artemisinins; Calcium Channel Blockers; Chloroquine; Humans; Malaria; Mefloquine; Naphthoquinones; Phenanthrenes; Primaquine; Quinine; Sesquiterpenes; Sulfadoxine | 1991 |
Halofantrine hydrochloride--efficacy and safety in children with acute malaria.
Topics: Acute Disease; Animals; Antimalarials; Child; Child, Preschool; Female; Humans; Infant; Malaria; Male; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax; Safety | 1991 |
Halofantrine for the treatment of mefloquine chemoprophylaxis failures in Plasmodium falciparum infections.
Topics: Animals; Antimalarials; Drug Resistance; Humans; Malaria, Falciparum; Mefloquine; Military Personnel; Phenanthrenes; Plasmodium falciparum; Recurrence; Thailand | 1991 |
Pharmacokinetics of halofantrine in healthy Thai volunteers.
Topics: Adolescent; Adult; Antimalarials; Humans; Malaria; Male; Middle Aged; Phenanthrenes; Thailand | 1991 |
Reduced in vitro susceptibility to halofantrine of Plasmodium falciparum in West Africa.
Topics: Adult; Africa, Western; Animals; Antimalarials; Drug Resistance; Humans; In Vitro Techniques; Malaria; Male; Phenanthrenes; Plasmodium falciparum; Recurrence; Travel | 1990 |
Halofantrine to prevent falciparum malaria on return from malarious areas.
Topics: Africa, Central; Animals; Antimalarials; Humans; Malaria; Male; Phenanthrenes; Plasmodium falciparum; Travel | 1990 |
Cross-resistance between mefloquine and halofantrine.
Topics: Adult; Animals; Antimalarials; Drug Resistance; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum | 1990 |
Pharmacokinetics of halofantrine in Thai patients with acute uncomplicated falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Animals; Antimalarials; Humans; Malaria; Middle Aged; Phenanthrenes; Plasmodium falciparum | 1991 |
An improved high-performance liquid chromatographic method for the simultaneous measurement of halofantrine and desbutylhalofantrine in human serum.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Humans; Malaria; Phenanthrenes; Ultraviolet Rays | 1991 |
In vitro and clinical correlates of mefloquine resistance of Plasmodium falciparum in eastern Thailand.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Butylated Hydroxytoluene; Chloroquine; Drug Resistance; Drugs, Chinese Herbal; Mefloquine; Molecular Structure; Phenanthrenes; Plasmodium falciparum; Pyridines; Pyrimethamine; Quinine; Sesquiterpenes; Thailand | 1991 |
[Imported malaria in Bordeaux in 1989. Epidemiologic, clinical and therapeutic study of 71 cases].
Topics: Animals; Antimalarials; Chloroquine; Female; France; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Travel | 1990 |
[The treatment of imported Plasmodium falciparum malaria with halofantrine. Apropos of 59 case reports (corrected and republished article orginally printed in Med Trop (Mars) 1990 Jan-Mar;50(1):113-7)].
Topics: Adolescent; Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria; Male; Phenanthrenes; Plasmodium falciparum; Travel | 1990 |
Clinical experience with halofantrine in the treatment of malaria.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Evaluation Studies as Topic; Follow-Up Studies; Hematologic Tests; Humans; Infant; Liver Function Tests; Malaria; Male; Middle Aged; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax | 1990 |
[Clinical and therapeutic approach in Plasmodium falciparum malaria in non-immune patients].
Topics: Animals; Drug Resistance, Microbial; Humans; Malaria; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine | 1990 |
[Cross resistance to mefloquine and halofantrine in a case of P. falciparum malaria contracted in Sierra Leone].
Topics: Adult; Animals; Antimalarials; Chloroquine; Cross Reactions; Drug Resistance; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum | 1990 |
[Halofantrine hydrochloride in the treatment of Plasmodium falciparum malaria in a region of resistance. Analysis of 54 pediatric cases].
Topics: Animals; Antimalarials; Child; Child, Preschool; Democratic Republic of the Congo; Drug Resistance; Female; Humans; Infant; Malaria; Male; Phenanthrenes; Plasmodium falciparum | 1990 |
In vitro sensitivity of multiresistant Plasmodium falciparum to new candidate antimalarial drugs in western Thailand.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Humans; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Thailand | 1990 |
[Insufficiency of treatment with halofantrine in chloroquinoresistant Plasmodium falciparum malaria in Sierra Leone].
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance; Female; Humans; Malaria; Phenanthrenes; Plasmodium falciparum; Sierra Leone | 1990 |
Lack of effect of halofantrine on hepatic drug metabolism in the rat in vivo and in vitro.
Topics: Animals; Antimalarials; Antipyrine; Bile; Female; Male; Mice; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; Perfusion; Phenanthrenes; Rats; Rats, Inbred Strains | 1990 |
Halofantrine and pruritus.
Topics: Child; Child, Preschool; Chloroquine; Drug Eruptions; Humans; Nigeria; Phenanthrenes; Pruritus; Time Factors | 1989 |
Structure of the antimalarial halofantrine hydrochloride.
Topics: Antimalarials; Chemical Phenomena; Chemistry, Physical; Crystallization; Crystallography; Hydrogen Bonding; Molecular Structure; Phenanthrenes | 1989 |
[Halofantrine in the treatment of malaria. Clinical trial in a semi-rural zone of Cameroon].
Topics: Adolescent; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Female; Humans; Malaria; Male; Phenanthrenes; Plasmodium falciparum; Rural Population | 1989 |
Chiral separation of the optical isomers of the antimalarial drug halofantrine.
Topics: Antimalarials; Phenanthrenes; Spectrophotometry, Ultraviolet; Stereoisomerism | 1989 |
[New antiparasitic drugs].
Topics: Amebicides; Anthelmintics; Antifungal Agents; Antimalarials; Artemisinins; Fluconazole; Humans; Itraconazole; Ketoconazole; Mefloquine; Phenanthrenes; Quinolines; Sesquiterpenes; Triazoles | 1988 |
[Efficacy of halofantrine in Plasmodium falciparum or Plasmodium vivax malaria in a resistance area (French Guiana)].
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Drug Resistance; Drug Tolerance; Female; French Guiana; Humans; Infant; Malaria; Male; Middle Aged; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax | 1988 |
Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro.
Topics: Animals; Antimalarials; Butylated Hydroxytoluene; Chemical Phenomena; Chemistry; Culture Media; Drug Resistance; Isoenzymes; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Quinolines | 1988 |
Hypoglycaemia and antimalarial drugs: quinidine and release of insulin.
Topics: Amodiaquine; Antimalarials; Blood Glucose; Chloroquine; Humans; Hypoglycemia; Insulin; Mefloquine; Phenanthrenes; Quinidine; Quinolines; Thailand | 1986 |
Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Humans; Phenanthrenes; Spectrophotometry, Ultraviolet; Temperature | 1988 |
Determination of halofantrine and its principal metabolite desbutylhalofantrine in biological fluids by reversed-phase high-performance liquid chromatography.
Topics: Adult; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Male; Phenanthrenes; Spectrophotometry, Ultraviolet | 1988 |
Interaction of ferriprotoporphyrin IX with the antimalarials amodiaquine and halofantrine.
Topics: Amodiaquine; Antimalarials; Heme; Hemin; Phenanthrenes; Spectrophotometry | 1988 |
Evaluation of an in vitro assay system for drug susceptibility of field isolates of Plasmodium falciparum from southern Thailand.
Topics: Amodiaquine; Animals; Antimalarials; Butylated Hydroxytoluene; Chloroquine; Humans; Mefloquine; Parasitology; Phenanthrenes; Plasmodium falciparum; Pyridines; Pyrimethamine; Quinine; Quinolines; Thailand; Triazines | 1988 |
The chemotherapy of rodent malaria. XLII. Halofantrine and halofantrine resistance.
Topics: Animals; Antimalarials; Drug Resistance; Malaria; Male; Mice; Phenanthrenes; Plasmodium berghei | 1987 |
Treatment of imported cases of falciparum malaria in France with halofantrine.
Topics: Adult; Antimalarials; Female; France; Humans; Malaria; Male; Middle Aged; Phenanthrenes; Plasmodium falciparum | 1986 |
Antimalarial drug susceptibility testing of Plasmodium falciparum in Thailand using a microdilution radioisotope method.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Lethal Dose 50; Malaria; Male; Mefloquine; Microbial Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Quinine; Quinolines; Thailand | 1985 |
Mefloquine failure in a case of falciparum malaria induced with a multidrug-resistant isolate in a non-immune subject.
Topics: Adult; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Quinine; Quinolines | 1985 |
Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs.
Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Madagascar; Malaria; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines | 1985 |
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of 2 years' study].
Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; In Vitro Techniques; Madagascar; Malaria; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines | 1985 |
Cloning and characterization of mefloquine-resistant Plasmodium falciparum from Thailand.
Topics: Adult; Animals; Antimalarials; Clone Cells; Drug Resistance; Glucose-6-Phosphate Isomerase; Humans; Isoenzymes; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinolines; Thailand | 1985 |
[Treatment with halofantrine of Plasmodium falciparum malaria imported into France].
Topics: Adult; Africa, Western; Antimalarials; Female; France; Humans; Malaria; Male; Middle Aged; Phenanthrenes; Plasmodium falciparum; Travel | 1985 |
Paired-ion liquid chromatographic method for the analysis of a phenanthrenemethanol antimalarial in whole blood.
Topics: Animals; Antimalarials; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dogs; Drug Stability; Humans; Phenanthrenes; Spectrophotometry, Ultraviolet | 1985 |
Type II mefloquine resistance in Thailand.
Topics: Adult; Antimalarials; Drug Resistance, Microbial; Humans; Malaria; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinolines; Thailand | 1982 |
[Drug sensitivity of Plasmodium falciparum in Madagascar. V. Study of the in vitro activity of quinine, mefloquine and halofantrine].
Topics: Antimalarials; Chloroquine; Humans; Mefloquine; Microbial Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Quinine; Quinolines | 1984 |
A comparison of thermospray and direct liquid introduction high-performance liquid chromatography/mass spectrometry for the analysis of candidate antimalarials.
Topics: Animals; Antimalarials; Chromatography, High Pressure Liquid; Dogs; Mass Spectrometry; Phenanthrenes | 1984 |
Evaluation of the antimalarial activity of the phenanthrenemethanol halofantrine (WR 171,669).
Topics: Animals; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Humans; Malaria; Phenanthrenes; Plasmodium falciparum; Recurrence | 1982 |
Immunoassay of racemic drugs: a problem of enantioselective antisera and a solution.
Topics: Animals; Antibody Specificity; Binding, Competitive; Cattle; Immune Sera; Immunoassay; Phenanthrenes; Rabbits; Stereoisomerism; Thyroglobulin; Time Factors | 1982 |
Use of halofantrine as standby treatment for malaria.
Topics: Antimalarials; Contraindications; Humans; Malaria; Phenanthrenes | 1993 |
Effect of halofantrine and its desbutyl metabolite on lymphocyte proliferation dynamics.
Topics: Adult; Analysis of Variance; Animals; Antimalarials; Cell Division; Chloroquine; Humans; In Vitro Techniques; Lymphocytes; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley | 1995 |
[Prolonged QT interval and cardiac toxicity due to halofantrine].
Topics: Adult; Antimalarials; Arrhythmias, Cardiac; Electrocardiography; Humans; Male; Phenanthrenes | 1995 |
New solid-phase extraction for an improved high-performance liquid chromatographic procedure for the quantitation of halofantrine and monodesbutylhalofantrine in blood or plasma.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Humans; Phenanthrenes; Reference Standards; Reproducibility of Results; Spectrometry, Fluorescence | 1995 |
Inhibitors of cAMP-dependent protein kinase impair long-term memory formation in day-old chicks.
Topics: Animals; Avoidance Learning; Brain; Chickens; Conditioning, Classical; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Mental Recall; Phenanthrenes; Retention, Psychology | 1995 |
Current views on the mechanisms of resistance to quinoline-containing drugs in Plasmodium falciparum.
Topics: Animals; Antimalarials; Biological Transport; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Phenanthrenes; Plasmodium falciparum; Verapamil | 1995 |
A simplified liquid chromatography assay for the quantitation of halofantrine and desbutylhalofantrine in plasma and identification of a degradation product of desbutylhalofantrine formed under alkaline conditions.
Topics: Animals; Antimalarials; Biotransformation; Chromatography, Liquid; Dogs; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Phenanthrenes | 1995 |
Quinine resistant falciparum malaria acquired in east Africa.
Topics: Adult; Africa, Eastern; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Tetracycline | 1995 |
[Plasma levels of halofantrine during two therapeutic sessions at a 7 day interval].
Topics: Adult; Antimalarials; Dose-Response Relationship, Drug; Humans; Malaria, Falciparum; Phenanthrenes | 1995 |
The antimalarial drug halofantrine is bound mainly to low and high density lipoproteins in human serum.
Topics: Animals; Binding Sites; Blood Proteins; Blotting, Western; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Molecular Weight; Orosomucoid; Phenanthrenes | 1995 |
Halofantrine in acute malaria.
Topics: Antimalarials; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Malaria, Vivax; Phenanthrenes | 1994 |
[Variation of cholostase enzymes (5'-nucleotidase and alkaline phosphatase) during a specific treatment for malaria in the Gabonese child].
Topics: 5'-Nucleotidase; Alkaline Phosphatase; Antimalarials; Child; Child, Preschool; Drug Combinations; Gabon; Humans; Infant; Malaria; Mefloquine; Phenanthrenes; Pyrimethamine; Reference Values; Sulfadoxine | 1995 |
Specific inhibition of cyclic AMP-dependent protein kinase by the antimalarial halofantrine and by related phenanthrenes.
Topics: Amino Acid Sequence; Animals; Antimalarials; Cattle; Cyclic AMP-Dependent Protein Kinases; Heart; Liver; Molecular Sequence Data; Myocardium; Myosin-Light-Chain Kinase; Phenanthrenes; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Structure-Activity Relationship | 1994 |
[Late ventricular potentials and antimalarial treatment with halofantrine].
Topics: Adult; Antimalarials; Arrhythmias, Cardiac; Humans; Male; Phenanthrenes | 1994 |
Halofantrine in acute malaria.
Topics: Antimalarials; Blood Coagulation Disorders; Humans; Liver Diseases; Malaria; Phenanthrenes; Serum Albumin | 1994 |
Halofantrine in acute malaria.
Topics: Acute Disease; Antimalarials; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Malaria, Vivax; Phenanthrenes; Primaquine; Recurrence | 1994 |
Activity of azithromycin as a blood schizonticide against rodent and human plasmodia in vivo.
Topics: Administration, Oral; Animals; Antimalarials; Aotus trivirgatus; Artemisinins; Azithromycin; Disease Models, Animal; Doxycycline; Drug Therapy, Combination; Humans; Injections, Subcutaneous; Malaria; Malaria, Falciparum; Mice; Parasitemia; Phenanthrenes; Plasmodium berghei; Quinine; Sesquiterpenes | 1995 |
Plasmodium falciparum and Plasmodium vivax: lactate dehydrogenase activity and its application for in vitro drug susceptibility assay.
Topics: Animals; Antimalarials; Chloroquine; Colorimetry; Erythrocytes; Humans; L-Lactate Dehydrogenase; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Parasitemia; Phenanthrenes; Plasmodium falciparum; Plasmodium vivax; Quinine | 1995 |
[Malaria prophylaxis in travellers: the radical halofantrine cure after returning from an endemic zone should be abandoned].
Topics: Antimalarials; Drug Resistance; Heart Diseases; Humans; Malaria, Falciparum; Phenanthrenes; Travel | 1994 |
Direct determination of the enantiomers of the antimalarial drug halofantrine and its active metabolite N-desbutylhalofantrine in human plasma.
Topics: Adult; Antimalarials; Chromatography, High Pressure Liquid; Humans; Kinetics; Male; Middle Aged; Phenanthrenes; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 1994 |
A strong association between mefloquine and halofantrine resistance and amplification, overexpression, and mutation in the P-glycoprotein gene homolog (pfmdr) of Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Artemisinins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Blotting, Southern; Chloroquine; DNA Primers; DNA, Protozoan; Drug Resistance; Gene Amplification; Gene Expression; Genes, Protozoan; Mefloquine; Molecular Sequence Data; Phenanthrenes; Plasmodium falciparum; Point Mutation; Polymerase Chain Reaction; Quinine; RNA, Messenger; Selection, Genetic; Sequence Homology, Nucleic Acid; Sesquiterpenes | 1994 |
Plasma concentrations of the enantiomers of halofantrine and its main metabolite in malaria patients.
Topics: Adult; Antimalarials; Humans; Malaria; Middle Aged; Phenanthrenes; Stereoisomerism | 1994 |
Antimalarial prophylaxis.
Topics: Antimalarials; Arrhythmias, Cardiac; Humans; Malaria; Phenanthrenes; Self Medication | 1994 |
[Cardiac complications of halofantrine: continuous electrocardiographic study (holter) in 20 patients].
Topics: Antimalarials; Electrocardiography, Ambulatory; Heart Diseases; Humans; Phenanthrenes; Prospective Studies | 1993 |
Halofantrine (halfan)
Topics: Antimalarials; Drug Administration Schedule; Humans; Marketing of Health Services; Phenanthrenes | 1993 |
Recrudescence of falciparum malaria following treatment with halofantrine.
Topics: Antimalarials; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Recurrence | 1994 |
[Plasmodium falciparum malaria resistant to halofantrine in Madagascar. A case].
Topics: Adult; Antimalarials; Drug Resistance, Microbial; Humans; Madagascar; Malaria, Falciparum; Male; Phenanthrenes | 1994 |
In vitro susceptibility of Cambodian isolates of Plasmodium falciparum to halofantrine, pyronaridine and artemisinin derivatives.
Topics: Adult; Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Humans; In Vitro Techniques; Mefloquine; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Sesquiterpenes; Triazines | 1994 |
Dangers of antimalarial standby treatment.
Topics: Antimalarials; Appendicitis; Diagnostic Errors; Humans; Malaria; Male; Netherlands; Papua New Guinea; Phenanthrenes; Self Administration; Travel | 1994 |
Clinical efficacy and pharmacokinetics of micronized halofantrine for the treatment of acute uncomplicated falciparum malaria in nonimmune patients.
Topics: Acute Disease; Administration, Oral; Adult; Animals; Antimalarials; Chemistry, Pharmaceutical; Half-Life; Humans; Malaria, Falciparum; Middle Aged; Phenanthrenes; Plasmodium falciparum; Tablets; Treatment Outcome | 1994 |
Sudden deaths while on halofantrine treatments--a report of two cases from peshawar.
Topics: Adult; Animals; Antimalarials; Child, Preschool; Death, Sudden, Cardiac; Female; Humans; Malaria, Vivax; Male; Pakistan; Phenanthrenes | 1994 |
Provocation of ventricular tachycardia by antimalarial drug halofantrine in congenital long QT syndrome.
Topics: Adolescent; Adult; Antimalarials; Electrocardiography; Female; Follow-Up Studies; Humans; Long QT Syndrome; Male; Phenanthrenes; Syncope; Tachycardia, Ventricular; Torsades de Pointes | 1994 |
[Malaria prophylaxis: recommendations adapted again].
Topics: Antimalarials; Contraindications; Humans; Malaria, Falciparum; Mosquito Control; Phenanthrenes | 1994 |
Fast emergence of Plasmodium falciparum resistance to halofantrine.
Topics: Adolescent; Adult; Animals; Antimalarials; Cameroon; Child; Child, Preschool; Congo; Drug Resistance; Humans; Infant; Malaria, Falciparum; Middle Aged; Phenanthrenes; Plasmodium falciparum | 1993 |
Artemisinin compounds in treatment of malaria.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Cambodia; Drug Approval; Drug Resistance; Humans; Malaria, Falciparum; Male; Military Personnel; Netherlands; Phenanthrenes; Sesquiterpenes | 1993 |
Halofantrine resistance in African countries.
Topics: Africa; Animals; Antimalarials; Congo; Drug Resistance; Humans; Malaria, Falciparum; Phenanthrenes; Plasmodium falciparum | 1993 |
Halofantrine resistance in African countries.
Topics: Adult; Animals; Antimalarials; Child; Drug Resistance; Humans; Malaria, Falciparum; Phenanthrenes; Plasmodium falciparum; Treatment Failure | 1993 |
Prolonged QT interval with halofantrine.
Topics: Adult; Antimalarials; Electrocardiography; Female; Humans; Long QT Syndrome; Phenanthrenes | 1993 |
Prolonged QT interval with halofantrine.
Topics: Adult; Antimalarials; Female; Humans; Long QT Syndrome; Phenanthrenes; Torsades de Pointes | 1993 |
Cardiac effect of halofantrine.
Topics: Adolescent; Adult; Antimalarials; Arrhythmias, Cardiac; Bradycardia; Electrocardiography; Heart; Heart Block; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes | 1993 |
In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Chloroquine; Drug Resistance; Humans; Mefloquine; Phenanthrenes; Plasmodium falciparum; Proguanil; Pyrimethamine; Quinine; Triazines | 1994 |
[Difficulties of diagnosis and treatment of malaria outbreaks in Europeans living in Burkina Faso].
Topics: Adult; Burkina Faso; Child, Preschool; Chloroquine; Drug Resistance; Europe; Humans; Infant; Malaria, Falciparum; Phenanthrenes; Recurrence | 1993 |
[Ventricular arrhythmia and halofantrine intake. Probable deleterious effect. Apropos of 3 cases].
Topics: Adult; Africa; Arrhythmias, Cardiac; Female; France; Heart Ventricles; Humans; Malaria, Falciparum; Phenanthrenes | 1993 |
[A case of Plasmodium falciparum malaria successfully treated with halofantrine].
Topics: Adult; Animals; Antimalarials; Humans; Malaria, Falciparum; Male; Phenanthrenes; Plasmodium falciparum; Travel | 1994 |
Antimalarial prophylaxis. Manufacturers recommend more stringent guidelines for halofantrine.
Topics: Antimalarials; Humans; Malaria; Phenanthrenes | 1994 |
Drug alert: halofantrine.
Topics: Antimalarials; Electrocardiography; Humans; Long QT Syndrome; Malaria, Falciparum; Malaria, Vivax; Phenanthrenes | 1993 |
Efficacy of micronized halofantrine in semi-immune patients with acute uncomplicated falciparum malaria in Cameroon.
Topics: Adolescent; Adult; Alanine Transaminase; Antimalarials; Aspartate Aminotransferases; Cameroon; Child; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Recurrence | 1993 |
Halofantrine treatment of Plasmodium falciparum malaria.
Topics: Adult; Aged; Antimalarials; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes | 1994 |
In vitro sensitivity of southern African isolates of Plasmodium falciparum to halofantrine.
Topics: Africa, Southern; Animals; Antimalarials; Dose-Response Relationship, Drug; Phenanthrenes; Plasmodium falciparum | 1993 |
Development of halofantrine resistance and determination of cross-resistance patterns in Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Erythrocytes; Humans; Phenanthrenes; Plasmodium falciparum | 1993 |
Clinical evaluation of halofantrine in acute malaria.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Child; Female; Humans; Malaria; Male; Middle Aged; Phenanthrenes | 1993 |
Efficacy and safety of halofantrine in acute malaria.
Topics: Adolescent; Adult; Aged; Antimalarials; Female; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Middle Aged; Phenanthrenes | 1993 |
Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine.
Topics: Animals; Chromosome Mapping; Drug Resistance; Gene Amplification; Gene Expression; Genes, Protozoan; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine | 1994 |
Direct determination of the enantiomers of halofantrine and its pharmacologically active metabolite N-desbutylhalofantrine by high-performance liquid chromatography.
Topics: Animals; Antimalarials; Biotransformation; Chromatography, High Pressure Liquid; In Vitro Techniques; Liver; Microsomes, Liver; Phenanthrenes; Rats; Stereoisomerism | 1993 |
[Halofantrine in the treatment of imported malaria in non-immune travelers].
Topics: Antimalarials; Female; Humans; Malaria; Male; Middle Aged; Phenanthrenes; Travel | 1993 |
Falciparum malaria: differential effects of antimalarial drugs on ex vivo parasite viability during the critical early phase of therapy.
Topics: Animals; Antimalarials; Drug Combinations; Drug Therapy, Combination; Humans; Malaria, Falciparum; Phenanthrenes; Plasmodium falciparum; Pyrimethamine; Quinine; Sulfadoxine; Time Factors | 1993 |
[Antimalarial measures in expatriates in the Congo. Trends 1989-1992].
Topics: Adult; Aminoquinolines; Antimalarials; Child; Child, Preschool; Congo; Ethnicity; Female; Health Knowledge, Attitudes, Practice; Humans; Malaria, Falciparum; Male; Patient Compliance; Phenanthrenes; Surveys and Questionnaires | 1993 |
[Mislead by 'malaria medication in one's pocket'].
Topics: Antimalarials; Appendicitis; Diagnosis, Differential; Fever; Humans; Malaria; Male; Middle Aged; Phenanthrenes | 1993 |
In vitro activity of artemisinin derivatives against African isolates and clones of Plasmodium falciparum.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Resistance; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Sesquiterpenes | 1993 |
Halofantrine--an alternative treatment for malaria.
Topics: Antimalarials; Child; Heart; Humans; Malaria, Falciparum; Phenanthrenes | 1993 |
Pharmacological activity and structure-activity relationship of (+/-)-erythro-mefloquine and related compounds on the isolated mouse phrenic nerve diaphragm preparation.
Topics: Animals; Antimalarials; Bungarotoxins; Electric Stimulation; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mefloquine; Mice; Models, Molecular; Molecular Conformation; Muscle Contraction; Neuromuscular Junction; Phenanthrenes; Phrenic Nerve; Quinine; Quinolines; Structure-Activity Relationship | 1993 |
Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand.
Topics: Animals; Antimalarials; Base Sequence; DNA, Protozoan; Drug Resistance; Gene Amplification; Genes, Protozoan; Humans; Malaria, Falciparum; Mefloquine; Molecular Sequence Data; Phenanthrenes; Plasmodium falciparum; RNA, Messenger; RNA, Protozoan; Thailand | 1993 |
The use of antiprotozoan and anthelmintic drugs during pregnancy and contraindications.
Topics: Albendazole; Antimalarials; Drug Approval; Female; Humans; Infant, Newborn; Mutagens; Phenanthrenes; Pregnancy; Pregnancy Complications, Parasitic; Teratogens | 1993 |
Derivation of highly mefloquine-resistant lines from Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Erythrocytes; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Serial Passage; Vacuoles | 1993 |
Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Mefloquine; Phenanthrenes; Plasmodium falciparum; Pyridines; Quinolines; Stereoisomerism; Structure-Activity Relationship | 1993 |
Halofantrine in the treatment of falciparum malaria.
Topics: Acute Disease; Adolescent; Adult; Antimalarials; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes | 1995 |
An investigation of the interaction between halofantrine, CYP2D6 and CYP3A4: studies with human liver microsomes and heterologous enzyme expression systems.
Topics: Alkylation; Antimalarials; Cloning, Molecular; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethanolamines; Felodipine; Genotype; Humans; Hydroxylation; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenanthrenes; Quinidine; Tacrine | 1995 |
A case of dual chloroquine and halofantrine treatment failure in Zimbabwe.
Topics: Adult; Antimalarials; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria, Falciparum; Male; Phenanthrenes; Pyrimethamine; Sulfadoxine; Zimbabwe | 1995 |
A liquid chromatographic assay for the stereospecific quantitative analysis of halofantrine in human plasma.
Topics: Anhydrides; Antimalarials; Chromatography, Liquid; Humans; Indicators and Reagents; Mass Spectrometry; Phenanthrenes; Sensitivity and Specificity; Stereoisomerism; Tartrates | 1995 |
Halofantrine in the treatment of malaria.
Topics: Administration, Oral; Antimalarials; Humans; Malaria; Phenanthrenes | 1995 |
Prolongation of the QT interval observed in a Japanese patient with vivax malaria following treatment with halofantrine.
Topics: Adult; Animals; Antimalarials; Electrocardiography; Humans; Malaria, Vivax; Male; Phenanthrenes; Plasmodium vivax; Travel | 1995 |
Electrocardiographic changes and halofantrine plasma level during acute falciparum malaria.
Topics: Acute Disease; Adult; Antimalarials; Electrocardiography; Heart; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes | 1996 |
Cardiac effects of standard-dose halofantrine therapy.
Topics: Adolescent; Adult; Aged; Antimalarials; Arrhythmias, Cardiac; Electrocardiography; Female; Heart; Heart Rate; Humans; Least-Squares Analysis; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Refugees; Vietnam | 1996 |
Plasmodium falciparum: molecular characterization of multidrug-resistant Cambodian isolates.
Topics: Alleles; Animals; Antimalarials; Blotting, Southern; Cambodia; Chloroquine; Codon; DNA Fingerprinting; DNA, Protozoan; Drug Resistance, Multiple; Folic Acid Antagonists; Genes, Protozoan; Genetic Variation; Humans; Mefloquine; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Proguanil; Pyrimethamine; Triazines | 1996 |
Antimalarial drugs reduce cytoadherence and rosetting Plasmodium falciparum.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemether; Artemisinins; Artesunate; Cell Adhesion; Erythrocytes; Humans; In Vitro Techniques; Malaria, Falciparum; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Rosette Formation; Sesquiterpenes | 1996 |
Blackwater fever after halofantrine.
Topics: Antimalarials; Blackwater Fever; Female; Humans; Middle Aged; Phenanthrenes | 1996 |
[Electrocardiographic changes due to halofantrine in the treatment of malaria: therapeutic implications].
Topics: Adult; Antimalarials; Data Interpretation, Statistical; Electrocardiography; Heart; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Prospective Studies; Time Factors | 1996 |
A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Chemical Phenomena; Chemistry, Physical; Dogs; Food; Intestinal Absorption; Male; Phenanthrenes; Solubility | 1996 |
[Diagnostic and prognostic importance of laboratory tests in malaria in airports. Study of six recent cases].
Topics: Adult; Aerospace Medicine; Antimalarials; Chloroquine; Female; France; Humans; Malaria, Falciparum; Male; Microbiological Techniques; Middle Aged; Phenanthrenes; Platelet Count; Prognosis; Quinine | 1996 |
The pfmdr1 gene of Plasmodium falciparum confers cellular resistance to antimalarial drugs in yeast cells.
Topics: Alleles; Animals; Antimalarials; ATP-Binding Cassette Transporters; Dose-Response Relationship, Drug; Drug Resistance; Mefloquine; Mice; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinacrine; Quinine | 1996 |
[The halofantrine treatment of Plasmodium falciparum malaria. Clinical experience].
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Drug Evaluation; Equatorial Guinea; Female; Humans; Infant; Malaria, Falciparum; Male; Nigeria; Phenanthrenes; Remission Induction; Spain | 1996 |
Mefloquine effect on disposition of halofantrine in the isolated perfused rat liver.
Topics: Animals; Antimalarials; Area Under Curve; Drug Interactions; In Vitro Techniques; Liver; Male; Mefloquine; Metabolic Clearance Rate; Perfusion; Phenanthrenes; Rats; Rats, Sprague-Dawley | 1996 |
Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion.
Topics: Anesthesia; Animals; Antimalarials; Drug Carriers; Duodenum; Emulsions; Intestinal Absorption; Lipoproteins; Lymphatic System; Male; Micelles; Phenanthrenes; Protein Binding; Rats; Rats, Sprague-Dawley | 1996 |
Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion.
Topics: Administration, Oral; Animals; Antimalarials; Drug Carriers; Fatty Acids; Intestinal Absorption; Lipoproteins; Lymphatic System; Male; Micelles; Phenanthrenes; Protein Binding; Rats; Rats, Sprague-Dawley; Triglycerides | 1996 |
Evaluation of the safety and efficacy of micronized halofantrine in the treatment of semi-immune patients with acute, Plasmodium falciparum malaria.
Topics: Adolescent; Adult; Antimalarials; Biological Availability; Child; Drug Compounding; Female; Humans; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Treatment Outcome | 1996 |
[2 cases of malarial flare-up with fatal outcome inspite of treatment with halofantrine].
Topics: Adult; Antimalarials; Fatal Outcome; Humans; Malaria; Male; Middle Aged; Phenanthrenes | 1996 |
In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Biological Transport; Chloroquine; DNA Fingerprinting; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Gene Dosage; Gene Expression; Immunoblotting; Mefloquine; Phenanthrenes; Plasmodium falciparum; Protozoan Proteins; Quinine; Selection, Genetic; Sequence Analysis, DNA; Verapamil | 1996 |
X-ray crystal structure of the antimalarial agent (-)-halofantrine hydrochloride supports stereospecificity for cardiotoxicity.
Topics: Antimalarials; Crystallography, X-Ray; Heart Diseases; Hydrogen Bonding; Molecular Conformation; Phenanthrenes; Quinidine; Quinine; Stereoisomerism | 1997 |
[Malaria in expatriates in Africa. 154 cases. Clinical problems and therapeutic difficulties].
Topics: Adult; Antimalarials; Female; France; Gabon; Humans; Malaria, Falciparum; Male; Military Personnel; Phenanthrenes; Quinine; Transients and Migrants | 1997 |
The chemotherapy of rodent malaria. LIV. Combinations of 'Fenozan B07' (Fenozan-50F), a difluorinated 3,3'-spirocyclopentane 1,2,4-trioxane, with other drugs against drug-sensitive and drug-resistant parasites.
Topics: Aminoquinolines; Animals; Antimalarials; Chloroquine; Drug Antagonism; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Malaria; Mefloquine; Mice; Naphthyridines; Parasitemia; Phenanthrenes; Phenylpropionates; Plasmodium berghei; Plasmodium yoelii | 1997 |
Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance; Folic Acid Antagonists; Genes, Protozoan; Phenanthrenes; Plasmodium falciparum; Pyrimethamine; Recombinant Proteins; Saccharomyces cerevisiae; Tetrahydrofolate Dehydrogenase; Triazines | 1997 |
[Anaphylactic shock related to the treatment of malaria with halofantrine].
Topics: Anaphylaxis; Antimalarials; Humans; Male; Middle Aged; Phenanthrenes | 1997 |
Halofantrine-associated ventricular fibrillation in a young woman with no predisposing QTc prolongation.
Topics: Adult; Antimalarials; Female; Humans; Long QT Syndrome; Phenanthrenes; Ventricular Fibrillation | 1997 |
Recrudescence of Plasmodium falciparum malaria contracted in Lombok, Indonesia after quinine/doxycycline and mefloquine: case report.
Topics: Adult; Animals; Anti-Bacterial Agents; Antimalarials; Doxycycline; Drug Combinations; Drug Resistance, Multiple; Humans; Indonesia; Malaria, Cerebral; Malaria, Falciparum; Male; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Recurrence | 1997 |
Comparison of the acute cardiotoxicity of the antimalarial drug halofantrine in vitro and in vivo in anaesthetized guinea-pigs.
Topics: Animals; Antimalarials; Blood Pressure; Electrocardiography; Guinea Pigs; Heart Rate; In Vitro Techniques; Long QT Syndrome; Male; Myocardial Contraction; Papillary Muscles; Phenanthrenes; Refractory Period, Electrophysiological | 1997 |
Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria.
Topics: Adolescent; Adult; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Humans; Infant; L-Lactate Dehydrogenase; Malaria, Falciparum; Male; Monitoring, Physiologic; Nigeria; Phenanthrenes; Pyrimethamine; Sesquiterpenes; Sulfadoxine; Treatment Outcome | 1997 |
Ion-pair reversed-phase high-performance liquid chromatographic analysis of halofantrine and desbutylhalofantrine in human plasma.
Topics: Administration, Oral; Antimalarials; Chromatography, High Pressure Liquid; Humans; Phenanthrenes | 1997 |
Differences in pre- and post-prandial plasma lipid profiles affect the extraction efficiency of a model highly lipophilic drug from beagle dog plasma.
Topics: Animals; Antimalarials; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Fasting; Lipids; Methyl Ethers; Phenanthrenes; Postprandial Period; Solvents; Triglycerides | 1997 |
Effect of altered serum lipid concentrations on the IC50 of halofantrine against Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Culture Media, Conditioned; Humans; Lipoproteins; Male; Phenanthrenes; Plasmodium falciparum; Protein Binding; Reference Values; Triglycerides | 1998 |
In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs.
Topics: Animals; Antimalarials; Artemether; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Erythrocytes; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Senegal; Sesquiterpenes | 1998 |
Follow-up of the susceptibility of Plasmodium falciparum to antimalarials in Gabon.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Dose-Response Relationship, Drug; Drug Resistance; Follow-Up Studies; Gabon; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Sesquiterpenes; Sulfadoxine | 1998 |
In vitro sensitivity of Plasmodium falciparum to halofantrine compared with chloroquine, quinine and mefloquine in the region of Bobo-Dioulasso, Burkina Faso (West Africa).
Topics: Animals; Antimalarials; Burkina Faso; Chloroquine; Drug Resistance; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine | 1998 |
Association of halofantrine with postprandially derived plasma lipoproteins decreases its clearance relative to administration in the fasted state.
Topics: Animals; Antimalarials; Area Under Curve; Biological Availability; Cholesterol; Diet; Dogs; Fasting; Injections, Intravenous; Lipoproteins; Phenanthrenes; Postprandial Period; Triglycerides | 1998 |
Chiral chromatographic method to determine the enantiomers of halofantrine and its main chiral desbutyl metabolite in erythrocytes.
Topics: Administration, Oral; Antimalarials; Chromatography, Liquid; Erythrocytes; Humans; Malaria; Phenanthrenes; Reproducibility of Results; Stereoisomerism | 1998 |
Recurrence of blackwater fever: triggering of relapses by different antimalarials.
Topics: Adult; Aged; Antimalarials; Belgium; Blackwater Fever; Diagnosis, Differential; Female; Humans; Male; Mefloquine; Middle Aged; Phenanthrenes; Quinine; Recurrence | 1998 |
[Treatment of malaria: let us be sensible!].
Topics: Antimalarials; Humans; Malaria, Falciparum; Phenanthrenes; Quinine; Severity of Illness Index | 1998 |
Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols.
Topics: Amodiaquine; Antimalarials; Chloroquine; Hemoglobins; Humans; Leucine; Mefloquine; Phenanthrenes; Primaquine; Protease Inhibitors | 1998 |
Halofantrine in the treatment of falciparum malaria.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Child, Preschool; Drug Administration Schedule; Follow-Up Studies; Humans; Malaria, Falciparum; Middle Aged; Pakistan; Parasitemia; Phenanthrenes | 1998 |
[Relapse of Plasmodium falciparum malaria after the return from the Ivory Coast. Type R1 halofantrine resistance or successive infections by 2 different strains?].
Topics: Animals; Antimalarials; Cote d'Ivoire; Drug Resistance; Female; Humans; Malaria, Falciparum; Middle Aged; Phenanthrenes; Plasmodium falciparum; Recurrence; Travel | 1998 |
Functional correlation of molecular electronic properties with potency of synthetic carbinolamine antimalarial agents.
Topics: Antimalarials; Mefloquine; Models, Molecular; Molecular Conformation; Phenanthrenes; Pyridines; Quinolines; Static Electricity; Structure-Activity Relationship | 1998 |
Submicron oil-in-water emulsion formulations for mefloquine and halofantrine: effect of electric-charge inducers on antimalarial activity in mice.
Topics: Animals; Antimalarials; Drug Interactions; Drug Stability; Emulsions; Excipients; Ions; Male; Mefloquine; Mice; Phenanthrenes; Static Electricity | 1998 |
In vitro susceptibility of Gabonese wild isolates of Plasmodium falciparum to artemether, and comparison with chloroquine, quinine, halofantrine and amodiaquine.
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistance, Microbial; Gabon; Humans; Infant; Malaria, Falciparum; Phenanthrenes; Plasmodium falciparum; Quinine; Sesquiterpenes | 1998 |
Altered pharmacokinetics of halofantrine by an antacid, magnesium carbonate.
Topics: Adsorption; Adult; Antacids; Antimalarials; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Interactions; Humans; Magnesium; Male; Phenanthrenes | 1998 |
Differences in the lipoprotein distribution of halofantrine are regulated by lipoprotein apolar lipid and protein concentration and lipid transfer protein I activity: in vitro studies in normolipidemic and dyslipidemic human plasmas.
Topics: Antimalarials; Carrier Proteins; Cholesterol Ester Transfer Proteins; Chromatography, High Pressure Liquid; Glycoproteins; Humans; Hyperlipidemias; In Vitro Techniques; Lipids; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Phenanthrenes; Triglycerides | 1999 |
In vitro susceptibility of African isolates of Plasmodium falciparum from Gabon to pyronaridine.
Topics: Adolescent; Amodiaquine; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Gabon; Humans; Infant; Malaria, Falciparum; Naphthyridines; Phenanthrenes; Plasmodium falciparum; Quinine | 1999 |
[Malaria--state of the art. 2: Therapy and prevention of malaria].
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Emergencies; Humans; Infant; Malaria; Phenanthrenes; Plasmodium falciparum; Quinine; Travel; Tropical Climate | 1999 |
Differences in the lipoprotein binding profile of halofantrine in fed and fasted human or beagle plasma are dictated by the respective masses of core apolar lipoprotein lipid.
Topics: Animals; Antimalarials; Cholesterol; Dogs; Fasting; Humans; Lipoproteins; Mice; Phenanthrenes; Phospholipids; Postprandial Period; Protein Binding; Triglycerides | 1999 |
[The proper use of antimalarial drugs currently available].
Topics: Animals; Antimalarials; Chemoprevention; Chloroquine; Contraindications; Drug Combinations; Drug Resistance; Endemic Diseases; Humans; Malaria; Malaria, Falciparum; Malaria, Vivax; Mefloquine; Phenanthrenes; Plasmodium; Plasmodium falciparum; Plasmodium malariae; Plasmodium vivax; Proguanil; Pyrimethamine; Quinine; Sulfadoxine; Travel | 1998 |
[Pulmonary manifestations associated with malaria].
Topics: Adult; Anti-Bacterial Agents; Antimalarials; Bronchitis; Child; Chloroquine; Female; Humans; Infant, Newborn; Lung Diseases; Malaria, Falciparum; Male; Mefloquine; Oxygen Inhalation Therapy; Phenanthrenes; Pleurisy; Pregnancy; Pregnancy Complications, Parasitic; Pulmonary Edema; Quinidine; Quinine; Respiratory Distress Syndrome, Newborn; Travel | 1998 |
Pharmacokinetics of halofantrine in the rat: stereoselectivity and interspecies comparisons.
Topics: Administration, Oral; Animals; Antimalarials; Chromatography, High Pressure Liquid; Dogs; Humans; Infusions, Intravenous; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism | 1999 |
In vitro susceptibility of African Plasmodium falciparum isolates to dihydroartemisinin and the risk factors for resistance to qinghaosu.
Topics: Africa; Animals; Antimalarials; Artemisinins; Chloroquine; Cross Reactions; Drug Evaluation, Preclinical; Drug Resistance; France; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Sesquiterpenes; Travel | 1998 |
Effect of selected antimalarial drugs and inhibitors of cytochrome P-450 3A4 on halofantrine metabolism by human liver microsomes.
Topics: Adolescent; Adult; Antifungal Agents; Antimalarials; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Ketoconazole; Male; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Phenanthrenes | 1999 |
Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.
Topics: Aryl Hydrocarbon Hydroxylases; Benzoflavones; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Activation; Humans; Isoenzymes; Ketoconazole; Kinetics; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; Phenanthrenes; Saccharomyces cerevisiae; Substrate Specificity | 1999 |
The antimalarial agent halofantrine perturbs phosphatidylcholine and phosphatidylethanolamine bilayers: a differential scanning calorimetric study.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Antimalarials; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Lipid Bilayers; Liposomes; Phenanthrenes; Phosphatidylcholines; Phosphatidylethanolamines; Temperature; Thermodynamics | 1999 |
Risk factors for gametocyte carriage in uncomplicated falciparum malaria.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Carrier State; Child; Child, Preschool; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Multivariate Analysis; Parasitemia; Phenanthrenes; Plasmodium falciparum; Prospective Studies; Quinine; Regression Analysis; Risk Factors; Seroepidemiologic Studies; Sesquiterpenes; Thailand | 1999 |
In vitro effects of racemates, separate enantiomers and major metabolites of mefloquine and halofantrine on metoprolol biotransformation by rat liver microsomes.
Topics: Animals; Antimalarials; Biotransformation; Male; Mefloquine; Metoprolol; Microsomes, Liver; Phenanthrenes; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1999 |
Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand.
Topics: Animals; Antimalarials; Blotting, Western; Chloroquine; DNA Fingerprinting; DNA, Protozoan; Drug Resistance; Electrophoresis, Agar Gel; Gene Dosage; Genotype; Humans; Malaria, Falciparum; Mefloquine; Penfluridol; Phenanthrenes; Phenotype; Plasmodium falciparum; Polymerase Chain Reaction; Quinine; Thailand; Verapamil | 1999 |
[Health assessments of a military company stationed on the Maroni River in French Guiana].
Topics: Acclimatization; Animals; Anti-Bacterial Agents; Antimalarials; Chloroquine; Condoms; Crotalid Venoms; Crotalus; Dermatomycoses; Doxycycline; France; French Guiana; Health Education; HIV Infections; Humans; Leishmaniasis, Cutaneous; Malaria, Falciparum; Military Personnel; Phenanthrenes; Quinine; Risk Factors; Sexual Abstinence; Snake Bites; Staphylococcal Skin Infections; Tropical Medicine | 1999 |
The microculture tetrazolium assay (MTA): another colorimetric method of testing Plasmodium falciparum chemosensitivity.
Topics: Animals; Antimalarials; Chloroquine; Colorimetry; Dose-Response Relationship, Drug; Drug Resistance; L-Lactate Dehydrogenase; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Tetrazolium Salts | 1999 |
[Imported pediatric malaria in Marseille].
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Comorbidity; Emigration and Immigration; Female; France; Humans; Infant; Malaria; Malaria, Falciparum; Male; Phenanthrenes; Recurrence; Travel | 1999 |
[Long QTc interval complicating halofantrine therapy in 2 children with Plasmodium falciparum malaria].
Topics: Adult; Antimalarials; Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Humans; Infant; Long QT Syndrome; Malaria, Falciparum; Male; Phenanthrenes | 1999 |
Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Gambia; Hematocrit; Humans; Malaria, Falciparum; Mefloquine; Parasitemia; Phenanthrenes; Plasmodium falciparum; Quinine; Scintillation Counting; Sensitivity and Specificity; Sesquiterpenes | 1999 |
Effects of mefloquine on cardiac contractility and electrical activity in vivo, in isolated cardiac preparations, and in single ventricular myocytes.
Topics: Animals; Antimalarials; Blood Pressure; Calcium; Cell Separation; Electrophysiology; Guinea Pigs; Heart; Heart Block; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Mefloquine; Myocardial Contraction; Myocardium; Papillary Muscles; Patch-Clamp Techniques; Phenanthrenes; Refractory Period, Electrophysiological | 2000 |
Caffeine and nicotinamide enhances the aqueous solubility of the antimalarial agent halofantrine.
Topics: Antimalarials; Caffeine; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Niacinamide; Phenanthrenes; Phosphates; Solubility | 2000 |
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.
Topics: Amino Acid Substitution; Animals; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; Chloroquine; Cloning, Molecular; Drug Resistance; Mefloquine; Mutation; Phenanthrenes; Plasmodium falciparum; Protozoan Proteins; Quinine; Sesquiterpenes; Verapamil | 2000 |
In vitro susceptibility of Plasmodium falciparum isolates to halofantrine in the Central Province of Papua New Guinea.
Topics: Animals; Antimalarials; In Vitro Techniques; Inhibitory Concentration 50; Malaria, Falciparum; Microbial Sensitivity Tests; Papua New Guinea; Phenanthrenes; Plasmodium falciparum | 1998 |
Cytoadherence characteristics of Plasmodium falciparum isolates in Thailand using an in vitro human lung endothelial cells model.
Topics: Adolescent; Adult; Animals; Antibodies, Monoclonal; Antimalarials; Binding, Competitive; Cell Adhesion; Cells, Cultured; Chondroitin Sulfates; Endothelium; Female; Humans; Intercellular Adhesion Molecule-1; Lung; Malaria, Falciparum; Male; Middle Aged; Parasitemia; Phenanthrenes; Plasmodium falciparum; Quinine; Rosette Formation; Thailand | 2000 |
The stereoselective distribution of halofantrine enantiomers within human, dog, and rat plasma lipoproteins.
Topics: Animals; Antimalarials; Dogs; Humans; Lipoproteins; Phenanthrenes; Rats; Stereoisomerism | 2000 |
Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats.
Topics: Animals; Antimalarials; Biological Availability; Biological Transport; Catheterization; Fatty Acids; Intestinal Mucosa; Lymph; Male; Pharmaceutical Vehicles; Phenanthrenes; Rats; Rats, Sprague-Dawley; Triglycerides | 2000 |
In vitro susceptibility of Plasmodium falciparum to four antimalarial drugs in the Central Province of Papua New Guinea.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; Mefloquine; Microbial Sensitivity Tests; Papua New Guinea; Phenanthrenes; Plasmodium falciparum; Quinine | 1998 |
Inhibition of HERG potassium channels by the antimalarial agent halofantrine.
Topics: Animals; Antimalarials; Cation Transport Proteins; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Electric Stimulation; Ether-A-Go-Go Potassium Channels; Gene Expression; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Phenanthrenes; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Time Factors | 2000 |
Modulation of halofantrine resistance after coadministration of halofantrine with diverse pharmacological agents in a rodent malaria model.
Topics: Animals; Antimalarials; Cyproheptadine; Disease Models, Animal; Drug Resistance; Female; Male; Mice; Phenanthrenes; Plasmodium falciparum | 2000 |
The formulation of Halofantrine as either non-solubilizing PEG 6000 or solubilizing lipid based solid dispersions: physical stability and absolute bioavailability assessment.
Topics: Antimalarials; Biological Availability; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Stability; Excipients; Gels; Phenanthrenes; Polyethylene Glycols; Solubility; Vitamin E | 2000 |
Effect of three structurally related antimalarial drugs on liver microsomal components and lipid peroxidation in rats.
Topics: Amodiaquine; Animals; Antimalarials; Endoplasmic Reticulum; Lipid Peroxidation; Male; Mefloquine; Microsomes, Liver; Oxidoreductases; Phenanthrenes; Rats; Rats, Wistar; Structure-Activity Relationship | 2000 |
Potentiation of halofantrine-induced QTc prolongation by mefloquine: correlation with blood concentrations of halofantrine.
Topics: Action Potentials; Animals; Antimalarials; Blood Gas Analysis; Drug Synergism; Electrocardiography; Female; Hemodynamics; Hydrogen-Ion Concentration; Long QT Syndrome; Mefloquine; Phenanthrenes; Potassium; Rabbits | 2001 |
Effects of anti-protozoal drugs and histopathological studies on trypanosome species.
Topics: Animals; Chloroquine; Female; Humans; Male; Metronidazole; Parasitic Sensitivity Tests; Phenanthrenes; Pyrimethamine; Rats; Trypanosoma; Trypanosomiasis | 2001 |
Halofantrine in G-6 PD deficiency.
Topics: Aged; Antimalarials; Chloroquine; Glycogen Storage Disease Type I; Hemolysis; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Phenanthrenes | 1997 |
Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A.
Topics: Adolescent; Adult; Amino Acid Sequence; Antimalarials; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Molecular Sequence Data; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Pedigree; Phenanthrenes; Sodium Channels; Tachycardia, Ventricular | 2001 |
From the Centers for Disease Control and Prevention. Sudden death in a traveler following halofantrine administration--Togo, 2000.
Topics: Adult; Anti-Bacterial Agents; Antimalarials; Cardiomegaly; Death, Sudden; Drug Interactions; Erythromycin; Humans; Macrolides; Male; Mefloquine; Phenanthrenes; Togo; Travel | 2001 |
Halofantrine-phospholipid interactions: monolayer studies.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Antimalarials; Chemical Phenomena; Chemistry, Physical; Cholesterol; Membranes, Artificial; Phenanthrenes; Phospholipids; Solubility; Surface Tension | 2001 |
Sudden death in a traveller following halofantrine administration--Togo, 2000.
Topics: Adult; Antimalarials; Cardiomyopathy, Hypertrophic; Contraindications; Death, Sudden, Cardiac; Humans; Long QT Syndrome; Malaria; Male; Mefloquine; Phenanthrenes; Togo; Travel | 2001 |
Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: four case reports.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Child; Drug Administration Schedule; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Phenanthrenes; Quinine; Sesquiterpenes; Sierra Leone; Treatment Failure | 2001 |
[Cardiac rhythm disturbances and prolonged QT interval with halofantrine].
Topics: Adolescent; Antimalarials; Bradycardia; Child; Child, Preschool; Electrocardiography; Female; Humans; Infant; Long QT Syndrome; Malaria; Male; Phenanthrenes | 2001 |
Comparison of the lymphatic transport of halofantrine administered in disperse systems containing three different unsaturated fatty acids.
Topics: Animals; Antimalarials; Chylomicrons; Emulsions; Fatty Acids, Unsaturated; Intestinal Mucosa; Lymphatic System; Phenanthrenes; Rats; Solubility; Solutions; Triglycerides | 2001 |
Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Biological Transport, Active; Catheterization; Consciousness; Fats, Unsaturated; Lymphatic System; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Triglycerides | 2001 |
A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine.
Topics: Administration, Oral; Animals; Antimalarials; Biological Transport, Active; Consciousness; Dogs; Enterocytes; Fasting; Intestinal Absorption; Liver; Lymphatic System; Male; Models, Animal; Phenanthrenes; Postprandial Period; Time Factors | 2001 |
Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes.
Topics: Animals; Antimalarials; Disease Models, Animal; Electrocardiography; Histamine Antagonists; Male; Phenanthrenes; Potassium Channel Blockers; Quaternary Ammonium Compounds; Rabbits; Terfenadine; Torsades de Pointes | 2002 |
Preparation and in vitro evaluation of solid dispersions of halofantrine.
Topics: Antimalarials; Drug Carriers; Drug Evaluation, Preclinical; Drug Stability; Phenanthrenes; Solubility | 2002 |
Stereoselective halofantrine and desbutylhalofantrine disposition in the rat: cardiac and plasma concentrations and plasma protein binding.
Topics: Animals; Antimalarials; Blood Proteins; Male; Myocardium; Phenanthrenes; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2002 |
Antimalarial drugs exacerbate rat liver microsomal lipid peroxidation in the presence of oxidants.
Topics: alpha-Tocopherol; Amodiaquine; Animals; Antimalarials; Antioxidants; Ascorbic Acid; Ferrous Compounds; Hydrogen Peroxide; Lipid Peroxidation; Lipid Peroxides; Liver; Male; Malondialdehyde; Mefloquine; Microsomes, Liver; Oxidants; Phenanthrenes; Rats; Reactive Oxygen Species; Up-Regulation | 2001 |
A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs.
Topics: Animals; Antimalarials; Area Under Curve; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Dogs; Food-Drug Interactions; Intestinal Absorption; Lymph; Lymphatic System; Male; Models, Molecular; Phenanthrenes; Postprandial Period; Solubility; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared | 2002 |
[Imported malaria in children in 1999. Study of the Armand-Trousseau Hospital in Paris].
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Emigration and Immigration; Female; Hospitalization; Humans; Incidence; Infant; Malaria; Male; Paris; Phenanthrenes; Recurrence; Retrospective Studies; Travel | 2002 |
A new high-performance liquid chromatography (HPLC) method for the analysis of halofantrine (HF) in pharmaceuticals.
Topics: Antimalarials; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Phenanthrenes; Reproducibility of Results; Sensitivity and Specificity | 2002 |
Proliposomes for oral drug administration.
Topics: Administration, Oral; Drug Carriers; Drug Delivery Systems; Glyburide; Humans; Liposomes; Phenanthrenes | 2002 |
The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins.
Topics: Administration, Oral; Animals; Antimalarials; Area Under Curve; Biological Availability; Blood Proteins; Cholesterol; Chromatography, High Pressure Liquid; Dietary Fats; Food-Drug Interactions; Hyperlipidemias; Injections, Intravenous; Lipid Metabolism; Lipids; Lipoproteins; Male; Peanut Oil; Phenanthrenes; Plant Oils; Poloxamer; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Triglycerides | 2002 |
[A collective malarial infestation during a humanitarian mission in west Africa].
Topics: Adult; Altruism; Animals; Antimalarials; Body Weight; Chemoprevention; Chloroquine; Drug Resistance; Humans; Malaria, Falciparum; Male; Mali; Mauritania; Middle Aged; Morocco; Phenanthrenes; Plasmodium falciparum; Proguanil; Quinine; Travel | 2002 |
The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.
Topics: Action Potentials; Antimalarials; Arrhythmias, Cardiac; Cation Transport Proteins; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Inhibitory Concentration 50; Kidney; Patch-Clamp Techniques; Phenanthrenes; Potassium Channels; Potassium Channels, Voltage-Gated; Trans-Activators; Transcriptional Regulator ERG; Transfection | 2002 |
Enhanced oral absorption of halofantrine enantiomers after encapsulation in a proliposomal formulation.
Topics: Animals; Antimalarials; Area Under Curve; Biological Availability; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Isomerism; Liposomes; Male; Methylcellulose; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2002 |
[Blackwater fever].
Topics: Adolescent; Adult; Aged; Antimalarials; Atovaquone; Blackwater Fever; Critical Care; Diagnosis, Differential; Drug Combinations; Humans; Mefloquine; Middle Aged; Naphthoquinones; Phenanthrenes; Prognosis; Proguanil; Pyrimethamine; Quinine; Sulfadoxine | 2002 |
Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats.
Topics: Administration, Oral; Animals; Biological Availability; Drug Delivery Systems; Intestinal Mucosa; Lymph; Lymphatic System; Pharmaceutical Vehicles; Phenanthrenes; Rats; Triglycerides | 2002 |
The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults.
Topics: Adolescent; Adult; Aged; Antimalarials; Community-Acquired Infections; Comorbidity; Cross Infection; Data Interpretation, Statistical; Exchange Transfusion, Whole Blood; Female; France; Glasgow Coma Scale; Humans; Injections, Intravenous; Intensive Care Units; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Phenanthrenes; Quinine; Retrospective Studies; Travel; World Health Organization | 2003 |
In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Gabon; Humans; Inhibitory Concentration 50; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Quinine | 2003 |
Identification of the 'wrong' active pharmaceutical ingredient in a counterfeit Halfan drug product using accurate mass electrospray ionisation mass spectrometry, accurate mass tandem mass spectrometry and liquid chromatography/mass spectrometry.
Topics: Chromatography, Liquid; Drug Contamination; Mass Spectrometry; Molecular Structure; Pharmaceutical Preparations; Phenanthrenes; Sensitivity and Specificity; Sulfamethazine; Sulfisomidine | 2003 |
[Adverse drug reactions (ADRs) to antimalarial drugs. Analysis of spontaneous report from the French pharmacovigilance database (1996-2000)].
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Antimalarials; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Chloroquine; Female; France; Humans; Infant; Infant, Newborn; Male; Middle Aged; Phenanthrenes; Proguanil; Psychoses, Substance-Induced; Sex Factors | 2003 |
Interaction of the antimalarial agents halofantrine and lumefantrine with lipid bilayers.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Antimalarials; Erythrocyte Membrane; Ethanolamines; Fluorenes; Lipid Bilayers; Lumefantrine; Male; Mice; Phenanthrenes; Phosphatidylcholines | 2003 |
In-vitro sensitivity of Plasmodium falciparum to chloroquine, halofantrine, mefloquine and quinine in Madagascar.
Topics: Animals; Antimalarials; Chloroquine; Drug Evaluation, Preclinical; Drug Resistance; Hospitals, Public; Hospitals, Urban; Humans; Madagascar; Malaria, Falciparum; Mefloquine; Microbial Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Quinine; Rural Health | 2002 |
Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo?
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dogs; Drug Administration Schedule; Lymph; Lymphatic System; Male; Models, Animal; Phenanthrenes; Stereoisomerism | 2003 |
[Long circulating nanocapsules: interest in the treatment of severe malaria with halofantrine].
Topics: Animals; Antimalarials; Capsules; Chemical Phenomena; Chemistry, Physical; Drug Delivery Systems; Malaria; Mice; Phenanthrenes; Plasmodium berghei; Solubility | 2003 |
Effects of halofantrine hydrochloride (halfan) on the histology of the ovary of mature female Wistar rats.
Topics: Administration, Oral; Animals; Antimalarials; Dose-Response Relationship, Drug; Female; Ovary; Phenanthrenes; Rats; Rats, Wistar | 2003 |
Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria.
Topics: Adolescent; Adult; Antimalarials; Electrocardiography; Female; Follow-Up Studies; Heart Rate; Humans; Infusions, Parenteral; Malaria, Falciparum; Male; Middle Aged; Phenanthrenes; Treatment Outcome | 1993 |
Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides.
Topics: Administration, Oral; Animals; Biological Availability; Biological Transport; Dogs; Drug Delivery Systems; Emulsions; Lymphatic System; Models, Animal; Phenanthrenes; Time Factors; Triglycerides | 2003 |
Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs.
Topics: Absorption; Administration, Oral; Animals; Biological Transport; Chemistry, Pharmaceutical; Dogs; Drug Carriers; Emulsions; Fasting; Intestinal Mucosa; Lipids; Lymphatic System; Phenanthrenes; Time Factors | 2003 |
Partitioning of halofantrine hydrochloride between water, micellar solutions, and soybean oil: Effects on its apparent ionization constant.
Topics: Antimalarials; Chemical Phenomena; Chemistry, Physical; Micelles; Phenanthrenes; Potentiometry; Solutions; Soybean Oil; Spectrophotometry, Ultraviolet | 2003 |
Halofantrine efficacy in non-immune children with imported acute Plasmodium falciparum malaria Infection.
Topics: Adolescent; Antimalarials; Child; Child, Preschool; Female; France; Humans; Immunity; Infant; Malaria, Falciparum; Male; Phenanthrenes; Prospective Studies; Recurrence; Travel; Treatment Outcome | 2004 |
Short report: in vivo sensitivity of Plasmodium falciparum to halofantrine in southern central Vietnam.
Topics: Adolescent; Adult; Animals; Antimalarials; Child; Child, Preschool; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Recurrence; Vietnam | 2003 |
Evaluation of the impact of altered lipoprotein binding conditions on halofantrine induced QTc interval prolongation in an anaesthetized rabbit model.
Topics: Animals; Antimalarials; Blood Proteins; Electrocardiography; Fasting; Food-Drug Interactions; Lipoproteins; Long QT Syndrome; Phenanthrenes; Postprandial Period; Protein Binding; Rabbits | 2004 |
Influence of physicochemical properties on the patterns of association of a series of aliphatic esters of halofantrine with plasma lipoproteins.
Topics: Antimalarials; Butyrates; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Humans; Lipoproteins; Lipoproteins, HDL; Oleic Acids; Phenanthrenes; Postprandial Period; Prodrugs; Protein Binding; Solubility; Stearates; Temperature; Thermodynamics; Ultracentrifugation | 2004 |
[Treatment of uncomplicated Plasmodium falciparum malaria in children: comparison of halofantrine with mefloquine].
Topics: Antimalarials; Child; Humans; Malaria, Falciparum; Mefloquine; Phenanthrenes; Retrospective Studies; Treatment Failure | 2003 |
Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations.
Topics: Cinnarizine; Danazol; Diazepam; Digestion; Griseofulvin; Models, Biological; Pharmaceutical Preparations; Pharmaceutical Solutions; Phenanthrenes; Solubility; Triglycerides; Water | 2004 |
Drug solubilization behavior during in vitro digestion of suspension formulations of poorly water-soluble drugs in triglyceride lipids.
Topics: Cinnarizine; Danazol; Diazepam; Digestion; Griseofulvin; Pharmaceutical Preparations; Phenanthrenes; Solubility; Suspensions; Triglycerides; Water | 2004 |
Efficacy and pharmacokinetics of intravenous nanocapsule formulations of halofantrine in Plasmodium berghei-infected mice.
Topics: Animals; Antimalarials; Area Under Curve; Biotransformation; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Malaria; Mice; Phenanthrenes; Plasmodium berghei | 2004 |
Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine.
Topics: Administration, Oral; Animals; Chemistry, Pharmaceutical; Digestion; Dogs; Male; Phenanthrenes; Solubility; Triglycerides; Water | 2004 |
Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum.
Topics: Animals; Antimalarials; Artemisinins; Chloroquine; DNA Damage; DNA Repair; Drug Resistance; Drug Resistance, Multiple; Humans; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Pyrimethamine; Quinine; Sesquiterpenes; Sulfanilamide; Sulfanilamides; Ultraviolet Rays | 2004 |
The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.
Topics: Animals; Antimalarials; Calcium; Cells, Cultured; Drug Resistance; Homeostasis; Mefloquine; Microscopy, Confocal; Models, Molecular; Nervous System Diseases; Neurons; Phenanthrenes; Plasmodium falciparum; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Rats | 2004 |
Determination of physicochemical properties of halofantrine.
Topics: Antimalarials; Chemical Phenomena; Chemistry, Physical; Hydrogen-Ion Concentration; Phenanthrenes; Solubility; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 2003 |
Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats.
Topics: Administration, Oral; Animals; Biological Availability; Biological Transport; Drug Delivery Systems; Emulsions; Injections, Intravenous; Intestinal Mucosa; Lymph; Lymphatic System; Male; Phenanthrenes; Phosphatidylcholines; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Surface-Active Agents; Triglycerides | 2004 |
Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents.
Topics: Alanine; Alleles; Amantadine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antimalarials; Chloroquine; Drug Resistance, Multiple; Genes, Protozoan; Haplotypes; Hemin; Membrane Proteins; Membrane Transport Proteins; Microsatellite Repeats; Molecular Sequence Data; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Point Mutation; Protein Structure, Secondary; Protozoan Proteins; Recombination, Genetic; Verapamil | 2004 |
Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine.
Topics: Animals; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Oocytes; Patch-Clamp Techniques; Phenanthrenes; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Binding; Xenopus laevis | 2004 |
Enzymatic characterization of lipid-based drug delivery systems.
Topics: Animals; Biopharmaceutics; Drug Delivery Systems; Emulsions; Lipase; Lipids; Lipolysis; Pancreas; Particle Size; Phenanthrenes; Probucol; Swine | 2005 |
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.
Topics: Alleles; Animals; Antimalarials; Artemisinins; Asparagine; Aspartic Acid; ATP-Binding Cassette Transporters; Drug Resistance; Mefloquine; Phenanthrenes; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinine; Sesquiterpenes | 2005 |
Bile increases intestinal lymphatic drug transport in the fasted rat.
Topics: Animals; Bile; Biological Transport; Chemistry, Pharmaceutical; Fasting; Fatty Acids; Intestinal Mucosa; Lymph; Male; Oleic Acid; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2005 |
The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.
Topics: Animals; Bile; Biological Transport; Drug Carriers; Intestinal Absorption; Intestinal Mucosa; Lipids; Lymph; Oleic Acid; Phenanthrenes; Rats | 2006 |
Analysis of the antimalarial drug halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by high performance liquid chromatography.
Topics: Antimalarials; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Phenanthrenes; Reproducibility of Results; Technology, Pharmaceutical; Time Factors | 2006 |
An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat.
Topics: Algorithms; Animals; Antimalarials; Chemistry, Pharmaceutical; DDT; Enterocytes; Insecticides; Lymphatic System; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2006 |
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.
Topics: Animals; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; DNA, Protozoan; Drug Resistance, Multiple; Ethanolamines; Fluorenes; Genes, MDR; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymerase Chain Reaction; Protozoan Proteins; Quinine; Sesquiterpenes | 2006 |
The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: evidence of tissue-specific enantioselectivity in microsomal metabolism.
Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Intestinal Mucosa; Ketoconazole; Male; Microsomes; Microsomes, Liver; Organ Specificity; Phenanthrenes; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2007 |
Comparative determination of halofantrine tablets by titrimetry, spectrophotometry and liquid chromatography.
Topics: Antimalarials; Chemistry, Pharmaceutical; Chromatography, Liquid; Phenanthrenes; Quality Control; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tablets; Titrimetry | 2006 |
Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach.
Topics: Algorithms; Animals; Antimalarials; Artemisinins; Artesunate; Bayes Theorem; Chloroquine; Computer Simulation; Dose-Response Relationship, Drug; Drug Resistance; False Positive Reactions; Inhibitory Concentration 50; Mefloquine; Models, Biological; Phenanthrenes; Plasmodium falciparum; Sesquiterpenes | 2007 |
Cardiotoxicity reduction induced by halofantrine entrapped in nanocapsule devices.
Topics: Animals; Antimalarials; Bradycardia; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hypotension; Lethal Dose 50; Long QT Syndrome; Malaria; Male; Mice; Nanocapsules; Phenanthrenes; Plasmodium berghei; Rats; Rats, Wistar | 2007 |
Intravascular haemolysis following treatment of malaria with halofantrine: case report.
Topics: Antimalarials; Child; Child, Preschool; Hemolysis; Humans; Malaria; Male; Nigeria; Phenanthrenes; Risk Factors | 2006 |
The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Chloroquine; Drug Resistance; Ghana; Humans; Infant; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Quinine; Sesquiterpenes | 2007 |
Lariam and Halfan.
Topics: Antimalarials; Humans; Malaria; Mefloquine; Mental Disorders; Phenanthrenes; Randomized Controlled Trials as Topic; Time Factors | 2007 |
Effect of polymer molecular weight on the production of drug nanoparticles.
Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Butanones; Chemistry, Pharmaceutical; Colloids; Drug Carriers; Drug Compounding; Excipients; Hypromellose Derivatives; Methylcellulose; Molecular Weight; Nabumetone; Nanoparticles; Particle Size; Phenanthrenes; Povidone; Solubility; Surface Properties; Technology, Pharmaceutical; Viscosity; Water | 2007 |
Dissolution properties and characterization of halofantrine-2-hydroxypropyl-beta-cyclodextrin binary systems.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; beta-Cyclodextrins; Crystallography, X-Ray; Freeze Drying; Indicators and Reagents; Kinetics; Phenanthrenes; Solubility; Spectrophotometry, Infrared; Water | 2007 |
Changes in antioxidant status and biochemical indices after acute administration of artemether, artemether-lumefantrine and halofantrine in rats.
Topics: Administration, Oral; Alanine Transaminase; Animals; Antimalarials; Antioxidants; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Aspartate Aminotransferases; Bilirubin; Biomarkers; Blood Urea Nitrogen; Catalase; Creatinine; Drug Combinations; Ethanolamines; Fluorenes; Glutathione; Glutathione Transferase; Intubation, Gastrointestinal; Kidney; Lipid Peroxidation; Liver; Male; Phenanthrenes; Rats; Rats, Wistar; Superoxide Dismutase; Time Factors | 2008 |
Differential effects of quinoline antimalarials on endocytosis in Plasmodium falciparum.
Topics: Amodiaquine; Animals; Antimalarials; Blotting, Western; Chloroquine; Endocytosis; Erythrocytes; Hemoglobins; Humans; Mefloquine; Peroxidase; Phenanthrenes; Plasmodium falciparum; Protein Binding; Protozoan Proteins; Quinolines | 2008 |
The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials.
Topics: Alcohols; Antimalarials; Binding Sites; Crystallography, X-Ray; Hemin; Molecular Structure; Phenanthrenes | 2008 |
Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
Topics: Administration, Oral; Animals; Antimalarials; Biological Availability; Chemistry, Pharmaceutical; Chylomicrons; Cycloheximide; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Intestines; Lymphatic System; Male; Phenanthrenes; Polysorbates; Rats; Rats, Sprague-Dawley; Solubility; Soybean Oil; Surface-Active Agents | 2008 |
The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine.
Topics: Animals; Antimalarials; Hyperlipidemias; Lipoproteins; Male; Microsomes, Liver; Phenanthrenes; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2009 |
Determination of lumefantrine in rat plasma by liquid-liquid extraction using LC-MS/MS with electrospray ionization: assay development, validation and application to a pharmacokinetic study.
Topics: Animals; Antimalarials; Calibration; Chromatography, High Pressure Liquid; Ethanolamines; Fluorenes; Indicators and Reagents; Lumefantrine; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2009 |
Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs.
Topics: Animals; Bile; Cytochrome P-450 Enzyme System; Intestinal Mucosa; Intestine, Small; Lipids; Microsomes, Liver; Peanut Oil; Phenanthrenes; Plant Oils; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2010 |
Lymphatic transport of Methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administration of MU.
Topics: Administration, Oral; Animals; Antimalarials; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dietary Fats; Dogs; Enterocytes; Estrenes; Fasting; Injections, Intravenous; Lymph; Lymphatic System; Male; Nandrolone; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solubility; Spectrophotometry, Ultraviolet; Triglycerides | 2009 |
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.
Topics: Amino Acid Sequence; Animals; Antimalarials; Drug Resistance; Humans; Kenya; Mefloquine; Membrane Transport Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Sequence Analysis, DNA; Sodium-Hydrogen Exchangers | 2010 |
Is halofantrine ototoxic? Experimental study on guinea pig cochlea model.
Topics: Animals; Antimalarials; Cochlea; Dose-Response Relationship, Drug; Guinea Pigs; Hair Cells, Auditory, Outer; Phenanthrenes; Staining and Labeling | 2010 |
Effect of experimental hyperlipidaemia on the electrocardiographic effects of repeated doses of halofantrine in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Electrocardiography; Hyperlipidemias; Long QT Syndrome; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2010 |
Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats.
Topics: Administration, Oral; Animals; Biological Availability; Chemical Precipitation; Dose-Response Relationship, Drug; Excipients; Gastrointestinal Tract; Male; Phenanthrenes; Polyethylene Glycols; Polysorbates; Rats; Rats, Sprague-Dawley | 2010 |
Measurement of lumefantrine and its metabolite in plasma by high performance liquid chromatography with ultraviolet detection.
Topics: Acetates; Artemether; Artemisinins; Calibration; Chemistry Techniques, Analytical; Chromatography; Chromatography, High Pressure Liquid; Ethanolamines; Fluorenes; Hexanes; Kinetics; Lumefantrine; Models, Chemical; Phenanthrenes; Regression Analysis; Reproducibility of Results; Spectrophotometry, Ultraviolet; Ultraviolet Rays | 2011 |
Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?
Topics: Animals; Chromatography, High Pressure Liquid; Cytokines; DDT; Drug Delivery Systems; Flow Cytometry; Immunomodulation; Indoles; Lymphocytes; Male; Mitogens; Phenanthrenes; Rats; Rats, Sprague-Dawley; Sirolimus | 2010 |
Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system.
Topics: Animals; Antimalarials; Arrhythmias, Cardiac; Guinea Pigs; Heart; Heart Conduction System; Mefloquine; Phenanthrenes; Quinidine; Quinine; Time Factors | 2010 |
A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs.
Topics: Administration, Oral; Animals; Biological Availability; Chemistry, Pharmaceutical; Excipients; Fluorocarbons; Lipolysis; Male; Pharmaceutical Preparations; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Triglycerides | 2011 |
In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).
Topics: Adolescent; Adult; Amodiaquine; Antimalarials; Child; Child, Preschool; Cote d'Ivoire; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Plasmodium falciparum; Quinine; Young Adult | 2010 |
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.
Topics: Antimalarials; Drug Resistance; Ethanolamines; Fluorenes; Gene Dosage; Gene Expression; Genetic Association Studies; Genetic Loci; Genetic Variation; Genotype; Haplotypes; Linkage Disequilibrium; Lumefantrine; Malaria, Falciparum; Mefloquine; Phenanthrenes; Plasmodium falciparum; Polymorphism, Single Nucleotide; Selection, Genetic | 2011 |
Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats.
Topics: Administration, Oral; Animals; Bile; Bile Ducts; Biological Availability; Chemical Precipitation; Drug Carriers; Gastrointestinal Transit; Intestinal Absorption; Male; Phenanthrenes; Polyethylene Glycols; Polysorbates; Rats; Rats, Sprague-Dawley; Solubility; Water | 2011 |
Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption.
Topics: Animals; Biological Transport; Chylomicrons; Fatty Acids; Hypertriglyceridemia; Intestinal Mucosa; Lipoproteins; Male; Models, Biological; Oleic Acid; Phenanthrenes; Rats; Rats, Sprague-Dawley; Triglycerides | 2011 |
Chemotherapeutic interaction between Khaya grandifoliola (WELW) CDC stem bark extract and two anti-malarial drugs in mice.
Topics: Administration, Oral; Animals; Antimalarials; Chloroquine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; Malaria; Meliaceae; Mice; Nigeria; Phenanthrenes; Plant Bark; Plant Extracts; Plasmodium yoelii; Treatment Outcome | 2010 |
In vitro properties of surface-modified solid lipid microspheres containing an antimalarial drug: halofantrine.
Topics: Animals; Antimalarials; Buffers; Drug Carriers; Gastric Juice; Goats; Hydrogen-Ion Concentration; Liposomes; Microspheres; Phenanthrenes | 2011 |
Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.
Topics: Aminoquinolines; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Chloroquine; Drug Combinations; Drug Resistance; Ethanolamines; Evolution, Molecular; Fluorenes; French Guiana; Gene Dosage; Haplotypes; Humans; Inhibitory Concentration 50; Longitudinal Studies; Malaria, Falciparum; Mefloquine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Practice Guidelines as Topic; Protozoan Proteins; Quinine | 2012 |
In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS).
Topics: Administration, Oral; Animals; Biological Availability; Dogs; Drug Carriers; Drug Compounding; Drug Delivery Systems; Drug Stability; Emulsions; Glycerides; In Vitro Techniques; Lipolysis; Male; Particle Size; Phenanthrenes; Solubility; Solvents; Surface-Active Agents; X-Ray Diffraction | 2012 |
Influence of bile on the absorption of halofantrine from lipid-based formulations.
Topics: Animals; Bile; Biological Availability; Chemistry, Pharmaceutical; Drug Delivery Systems; Intestinal Absorption; Lipids; Male; Oils; Particle Size; Phenanthrenes; Rats; Rats, Sprague-Dawley; Soybean Oil | 2012 |
Metabolic network analysis predicts efficacy of FDA-approved drugs targeting the causative agent of a neglected tropical disease.
Topics: Antimalarials; Drug Delivery Systems; Humans; Leishmania major; Leishmaniasis, Cutaneous; Metabolic Networks and Pathways; Neglected Diseases; Phenanthrenes; United States; United States Food and Drug Administration | 2012 |
Distribution of drug resistance genotypes in Plasmodium falciparum in an area of limited parasite diversity in Saudi Arabia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Combinations; Drug Resistance; Female; Genotype; Humans; Infant; Male; Mefloquine; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Proteins; Mutation; Phenanthrenes; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Pyrimethamine; Saudi Arabia; Sulfadoxine; Tetrahydrofolate Dehydrogenase; Young Adult | 2012 |
Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.
Topics: Animals; Antimalarials; Hepatocytes; Hyperlipidemias; Lipoproteins; Phenanthrenes; Rats; Rats, Sprague-Dawley; Stereoisomerism | 2012 |
Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.
Topics: Animals; Antimalarials; Biological Availability; Chemistry, Pharmaceutical; Emulsions; Injections, Intravenous; Lymph; Male; Metabolic Clearance Rate; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solvents | 2012 |
Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful.
Topics: Animals; Bile; Cholestyramine Resin; Intestinal Absorption; Intestinal Mucosa; Male; Models, Animal; Phenanthrenes; Polyethylene Glycols; Polysorbates; Rats; Rats, Sprague-Dawley | 2012 |
CDA: combinatorial drug discovery using transcriptional response modules.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combinatorial Chemistry Techniques; Computational Biology; Drug Discovery; Drug Resistance; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Models, Statistical; Phenanthrenes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Signal Transduction; Transcription, Genetic; Vinblastine | 2012 |
Effect of halofantrine on QT interval in children.
Topics: Adolescent; Antimalarials; Cardiac Electrophysiology; Child; Child, Preschool; Electrophysiological Phenomena; Female; Humans; Infant; Long QT Syndrome; Malaria, Falciparum; Male; Phenanthrenes | 2012 |
A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport.
Topics: Animals; Antimalarials; Biological Availability; Dogs; Female; Lipid Metabolism; Lipids; Lymphatic System; Male; Mice; Mice, Inbred C57BL; Models, Animal; Pharmaceutical Vehicles; Phenanthrenes; Phospholipids; Rats; Rats, Sprague-Dawley; Sex Factors; Species Specificity; Triglycerides | 2013 |
Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs.
Topics: Antimalarials; Base Sequence; DNA Copy Number Variations; Drug Resistance; Ethanolamines; Fluorenes; Gene Dosage; Gene Frequency; Genes, Protozoan; Lumefantrine; Malaria, Falciparum; Mefloquine; Mutation; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymorphism, Single Nucleotide; Protozoan Proteins; Sequence Analysis, DNA | 2013 |
The impact of lymphatic transport on the systemic disposition of lipophilic drugs.
Topics: Administration, Intravenous; Animals; DDT; Lipoproteins; Lymph; Male; Phenanthrenes; Plasma; Rats; Rats, Sprague-Dawley; Trichloroethanes | 2013 |
The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs.
Topics: Animals; Chemistry, Pharmaceutical; Cinnarizine; Colloids; Danazol; Fenofibrate; Intestinal Mucosa; Kinetics; Male; Models, Theoretical; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solubility | 2013 |
Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice.
Topics: Animals; Anthelmintics; Disease Models, Animal; Drug Synergism; Female; Humans; Intestines; Ketoconazole; Liver; Male; Mice; Parasite Load; Phenanthrenes; Quinine; Schistosoma mansoni; Schistosomiasis mansoni; Treatment Outcome | 2013 |
Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.
Topics: Animals; Antimalarials; Artemisinins; Cell Line; Cell Survival; Cells, Cultured; Chloroquine; Doxycycline; Drug Synergism; Drug Therapy, Combination; Erythrocytes; Humans; Interleukin-10; Interleukin-4; Malaria, Cerebral; Mefloquine; Mice; Mice, Inbred C57BL; Monocytes; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium berghei; Plasmodium falciparum | 2014 |
Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS method: application to drug interaction study.
Topics: Animals; Antimalarials; Blood Chemical Analysis; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Drug Combinations; Ethanolamines; Fluorenes; Lumefantrine; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS).
Topics: Animals; Antimalarials; Biological Availability; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Interactions; Emulsions; Enzyme Inhibitors; Excipients; Intestinal Absorption; Lactones; Lipolysis; Male; Orlistat; Phenanthrenes; Rats; Rats, Sprague-Dawley; Solubility | 2016 |
Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine.
Topics: Animals; Antimalarials; Chromatography, High Pressure Liquid; Ethanolamines; Fluorenes; Half-Life; Heterocyclic Compounds; Humans; Lumefantrine; Microsomes, Liver; Phenanthrenes; Quinolines; Rats; Spiro Compounds; Tandem Mass Spectrometry | 2015 |
Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging.
Topics: Chemistry, Pharmaceutical; Computer-Aided Design; Dosage Forms; Drug Delivery Systems; Drug Liberation; Pharmaceutical Preparations; Phenanthrenes; Polyesters; Polyvinyl Alcohol; Porosity; Printing; Printing, Three-Dimensional; Technology, Pharmaceutical; Terahertz Imaging; X-Ray Microtomography; X-Rays | 2017 |
Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.
Topics: Animals; Cinnarizine; Danazol; Glycerides; Lipids; Male; Pharmaceutical Solutions; Phenanthrenes; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Solubility; Suspensions; Water | 2017 |
The role of lecithin degradation on the pH dependent stability of halofantrine encapsulated fat nano-emulsions.
Topics: Drug Stability; Emulsions; Hydrogen-Ion Concentration; Lecithins; Nanoparticles; Particle Size; Phenanthrenes | 2017 |
The impact of digestion is essential to the understanding of milk as a drug delivery system for poorly water soluble drugs.
Topics: Animals; Biological Availability; Digestion; Drug Delivery Systems; Lipolysis; Milk; Phenanthrenes; Solubility; Water | 2018 |
Physical Characterization of Halofantrine-Encapsulated Fat Nanoemulsions.
Topics: Antimalarials; Drug Carriers; Drug Compounding; Drug Stability; Emulsions; Hydrogen-Ion Concentration; Isoelectric Point; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Phenanthrenes; Soybean Oil | 2019 |
Late clinical failure associated with cytochrome b codon 268 mutation during treatment of falciparum malaria with atovaquone-proguanil in traveller returning from Congo.
Topics: Antimalarials; Artemisinins; Atovaquone; Codon; Congo; Cytochromes b; Drug Combinations; Drug Resistance; Female; France; Humans; Malaria, Falciparum; Middle Aged; Mutation; Phenanthrenes; Plasmodium falciparum; Proguanil; Quinolines; Tetrahydrofolate Dehydrogenase; Travel | 2020 |
Low-Frequency Raman Scattering Spectroscopy as an Accessible Approach to Understand Drug Solubilization in Milk-Based Formulations during Digestion.
Topics: Administration, Oral; Aminoquinolines; Animals; Biological Availability; Clofazimine; Digestion; Drug Compounding; Drug Delivery Systems; Ferrous Compounds; Infant Formula; Lipolysis; Lumefantrine; Metallocenes; Milk; Phenanthrenes; Scattering, Small Angle; Solubility; Spectrum Analysis, Raman; Suspensions; Water; X-Ray Diffraction | 2020 |
Mechanistic Oral Absorption Modeling of Halofantrine: Exploring the Role of Intestinal Lymphatic Transport.
Topics: Administration, Oral; Intestinal Absorption; Intestines; Lymph; Models, Biological; Phenanthrenes; Postprandial Period | 2021 |
Impact of chemoprophylaxis immunisation under halofantrine (CPS-HF) drug cover in Plasmodium yoelii Swiss mice malaria model.
Topics: Animals; Chemoprevention; Immunization; Malaria; Mice; Mice, Inbred BALB C; Pharmaceutical Preparations; Phenanthrenes; Plasmodium yoelii | 2022 |